Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Clinical Medicine (Respiratory Medicine) Professor
Title
Professor
Atsunori Tsuchiya
Research Areas
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Life Science / Gastroenterology
Research Interests
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細胞外小胞
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膵癌
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再生医療
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肝細胞癌
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Major achievement
肝硬変
Proposed theme of joint or funded research
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消化器全般、再生医療
Research Projects
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ADR-001を用いたChild-Pugh Aの肝硬変患者を対象とした医師主導治験
Grant number：20314294 2021.4 - 2024.3
国立研究開発法人日本医療研究開発機構 日本医療研究開発機構研究費
寺井崇二、土屋淳紀、小野寺理、渡邉雄介
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Pancreatic cancer biomarker research by the exosome proteome analysis of the HGD rat pancreatic cancer model
Grant number：21K07910 2021.4 - 2024.3
Japan Society for the Promotion of Science Niigata University Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
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Development of a treatment to improve fibrosis and elucidation of carcinogenesis mechanisms in improved NASH model MC4RKO mice
Grant number：19H03636 2019.4 - 2022.3
Japan Society for the Promotion of Science Niigata University Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Terai Shuji
Using MC4R-KO mice, a mouse model of NASH, we first examined the effects on fibrosis and tumors to establish an early fibrosis model and an early tumorigenesis model. Using the early fibrosis model, we found that mesenchymal stem cells and their exosomes ameliorate inflammation and fibrosis. Furthermore, in the tumorigenesis model, we established an early tumorigenesis model by blocking S1P-S1PR2 signaling in MC4R-KO mice fed a high-fat diet with the drug JTE-013, and found that the mice showed a high rate of hepatocellular carcinoma at early stage.
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Grant number：20790488 2008 - 2009
Japan Society for the Promotion of Science Niigata University Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
TSUCHIYA Ataunori
In the liver, stromal cell derived factor-1 (SDF-1) is produced in the bile duct and hepatic stem/progenitor cells. In this study, we analyzed the role of SDF-1 by using the CXCR4 conditional knock out (KO) mice (CXCR4 is the receptor of SDF-1). By analyzing the liver damaged CXCR4 KO mice, we realized that although in the liver hepatic stem/progenitor cells increased, the recovery of liver regeneration was delayed. These results reveal that the role of SDF-1/CXCR4 axis works positive effect for liver regeneration.
Papers
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Guidance on the clinical application of extracellular vesicles. Reviewed Major achievement
Terai S, Asonuma M, Hoshino A, Kino-Oka M, Ochiya T, Okada K, Sato Y, Takahashi Y, Tobita M, Tsuchiya A.
Regen Ther. 2025 Mar 7;29:43-50. doi: 10.1016/j.reth.2025.02.008. PMID: 40124467; PMCID: PMC11930518. 2025.3
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Targeted animal models for preclinical assessment of cellular and gene therapies in pancreatic and liver diseases: regulatory and practical insights.
Wang H, Ciccocioppo R, Terai S, Shoeibi S, Carnevale G, De Marchi G, Tsuchiya A, Ishii S, Tonouchi T, Furuyama K, Yang Y, Mito M, Abe H, Di Tinco R, Cardinale V.
Cytotherapy. 2025 Mar;27(3):259-278. doi: 10.1016/j.jcyt.2024.11.008. Epub 2024 Nov 19. PMID: 39755978. 2025.3
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Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells.
Ishikawa N, Watanabe Y, Maeda Y, Yoshida T, Kimura N, Abe H, Sakamaki A, Kamimura H, Yokoo T, Kamimura K, Tsuchiya A, Terai S.
Regen Ther. 2025 Feb 4;28:509-516. doi: 10.1016/j.reth.2025.01.017. PMID: 39991509; PMCID: PMC11846928. 2025.2
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Pruritus in Chronic Cholestatic Liver Diseases, Especially in Primary Biliary Cholangitis: A Narrative Review.
Kanda T, Sasaki-Tanaka R, Kimura N, Abe H, Yoshida T, Hayashi K, Sakamaki A, Yokoo T, Kamimura H, Tsuchiya A, Kamimura K, Terai S.
Int J Mol Sci. 2025 Feb 22;26(5):1883. doi: 10.3390/ijms26051883. PMID: 40076514; PMCID: PMC11900276. 2025.2
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Small Intestinal Bacterial Overgrowth Is a Predictor of Overt Hepatic Encephalopathy in Patients with Liver Cirrhosis.
Sakamaki A, Yokoyama K, Yamazaki H, Wakabayashi T, Kojima Y, Tominaga K, Tsuchiya A, Kamimura K, Yokoyama J, Terai S.
J Clin Med. 2025 Feb 23;14(5):1491. doi: 10.3390/jcm14051491. PMID: 40094949; PMCID: PMC11901010. 2025.2
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Platelet-rich plasma-derived extracellular vesicles improve liver cirrhosis in mice.
Maeda Y, Watanabe Y, Ishikawa N, Yoshida T, Kimura N, Abe H, Sakamaki A, Kamimura H, Yokoo T, Kamimura K, Tsuchiya A, Terai S.
Regen Ther. 2024 Nov 6;26:1048-1057. doi: 10.1016/j.reth.2024.10.010. PMID: 39569343; PMCID: PMC11576940. 2024.11
Presentations
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細胞外小胞等の臨床応用に関するガイダンスの作成に関わって
土屋淳紀
第24回日本再生医療学会総会 2025.3
Awards
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Liver forum in Kyoto研究奨励賞
2007
Teaching Experience (On-campus)
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Gastroenterology （Basic Clinical Clerkship） Major achievement
2025Year
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Hepatology and viral hepatitis Seminar Major achievement
2025Year
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Hepatology and viral hepatitis Experiment Major achievement
2025Year
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Advanced Course of Liver Patho logy
2025Year
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Gastroenterology （Basic Clinical Clerkship） Major achievement
2024Year
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Internal Medicine 1 (Basic Clinical Clerkship) Major achievement
2024Year
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ACC実習 Major achievement
2024Year
Social Activities
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BSNラジオ近藤丈靖の独占ごきげんアワーでの肝炎啓発活動
Role(s)： Appearance
Professional Memberships
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日本内科学会
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日本消化器病学会
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日本肝臓学会
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日本消化器内視鏡学会
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日本再生医療学会
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日本細胞外小胞学会
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International Society of Extracellular Vesicles (ISEV；国際細胞外小胞学会)
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European Association for Study of Liver