Updated on 2024/06/30

写真a

 
Yokomichi Hiroshi
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Medicine (Epidemiology/Environmental Medicine) Professor
Title
Professor
Contact information
メールアドレス
Other name(s)
Hiroshi Yokomichi
Profile
Hiroshi Yokomichi, MD, PhD, MPH, DrPH, FRSM is working for observational and clinical epidemiologic studies on lifestyle-related diseases and child growth (diabetes and endocrinology). overseas fellow of the Royal Society of Medicine, champion for the Society for Epidemiologic Research, senior expert of the Japan Epidemiological Association and the Japanese Society of Public Health and specialist physician of social medicine.
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Name(s) appearing in print

  • Yokomichi H

  • Hiroshi Yokomichi

Research History

  • University of Yamanashi   Department of Epidemiology and Environmental Medicine   Professor   Professor

    2023.4

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    Country:Japan

    Job classification:Professor

  • University of Yamanashi   Department of Health Sciences   Associate Professor   Doctor

    2016.5 - 2022.3

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    Country:Japan

    Job classification:Associate professor/Lecturer (full time)

  • University of Oxford   Nuffield Department of Primary Care Health Sciences   Visiting Researcher   Doctor

    2014.9 - 2015.9

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    Country:United Kingdom

    Job classification:Researcher/Postdoc

  • University of Yamanashi   Department of Health Sciences   Assistant Professor   Doctor

    2011.1 - 2016.4

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    Country:Japan

    Job classification:Assistant professor

  • University of Yamanashi   Global COE Program   Research Assistant

    2010.4 - 2010.12

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    Country:Japan

    Job classification:Researcher/Postdoc

Education

  • University of Oxford   Nuffield College

    2014.9 - 2015.9

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    Country: United Kingdom

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  • University of Yamanashi   Philosophy of doctor course

    2010.4 - 2014.3

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  • University of Yamanashi   Philosophy of doctor course

    2010.4 - 2014.3

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    Country: Japan

    Course: Doctor course

  • National Institute of Public Health, Japan   Doctor of Public Health course

    2008.4 - 2013.3

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    Country: Japan

    Course: Others

  • National Institute of Public Health, Japan   Doctor of Public Health course

    2008.4 - 2013.3

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  • National Institute of Public Health, Japan   Master of Public Health course

    2007.4 - 2008.3

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    Country: Japan

    Course: Others

  • National Institute of Public Health, Japan   Master of Public Health course

    2007.4 - 2008.3

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  • University of Yamanashi   Department of Medicine   Bachelor course of medicine

    1999.4 - 2005.3

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  • University of Yamanashi   Department of Medicine   Bachelor course of medicine

    1999.4 - 2005.3

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    Country: Japan

    Course: Others

  • Kyoto University   Department of Science   Mathematics

    1991.4 - 1996.3

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  • Kyoto University   Department of Science   Mathematics

    1991.4 - 1996.3

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    Country: Japan

    Course: Others

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Degree

  • PhD in Medicine ( 2014.3   University of Yamanashi )

  • Doctor of Public Health ( 2013.3   National Institute of Public Health )

  • Master of Public Health in Biostatistics ( 2008.3   National Institute of Public Health )

Current state of research and teaching activities

  • I am working for epidemiologic studies on lifestyle-related diseases and child growth (diabetes and endocrinology).

Research Areas

  • Life Science / Hygiene and public health  / Hygiene and public health

Research Interests

  • Vaccines

  • Influenza infection

  • Cancer

  • Health Insurance Claim

  • Epidemiology

  • Child Growth

  • Obesity

  • Linear Models

  • Diabetes

  • Non-communicable diseases

  • Public Health Nutrition

Subject of research

  • Epidemiology of Diabetes

  • Epidemiology of Vaccines

  • Methodologies of Public Health Nutrition

  • Child Growth

  • Epidemiology of influenza

Proposed theme of joint or funded research

  • Epidemiologic studies of risk factors and complications of diabetes and lifestyle-related diseases

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    Possible form of cooperation:Technical Consultation, Funded Research, Cooperative Research Type of joint or funded research proposed:Wish to undertake joint research with industry and other organizations including private sector.

Research Projects

  • Developing a risk management index for diabetic complications based on individual differences in haemoglobin glycation

    2022.4 - 2026.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Mie Mochizuki

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    Authorship:Coinvestigator(s)  Grant type:Competitive  Type of fund::Science research expense

  • Investigation of long-term prognoses of Japanese child-onset type 1 diabetes

    2022.4 - 2025.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Hiroshi Yokomichi

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    Authorship:Principal investigator  Grant type:Competitive  Type of fund::Science research expense

  • Establishing a new glycemic control index using ratio glycated albumin to haemoglobin A1c

    2022.4 - 2023.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Mie Mochizuki

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Effect of delay of the onsets of diabetes and diabetic angiopathies on health life span and lifetime treatment cost

    2022.4 - 2023.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist

    Hiroshi Yokomichi

      More details

    Authorship:Principal investigator  Type of fund::Science research expense

  • Developing a risk management index for diabetic complications based on individual differences in haemoglobin glycation

    2022.4 - 2023.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Mie Mochizuki

      More details

    Grant type:Competitive 

    researchmap

  • Effect of delay of the onsets of diabetes and diabetic angiopathies on health life span and lifetime treatment cost

    2022.4 - 2023.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist

    Hiroshi Yokomichi

      More details

    Grant type:Competitive 

    researchmap

  • Effect of delay of the onsets of diabetes and diabetic angiopathies on health life span and lifetime treatment cost

    2021.4 - 2022.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist

    Hiroshi Yokomichi

      More details

    Authorship:Principal investigator  Type of fund::Science research expense

  • Establishing a new glycemic control index using ratio glycated albumin to haemoglobin A1c

    2021.4 - 2022.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Mie Mochizuki

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Investigation of long-term prognoses of Japanese child-onset type 1 diabetes

    2021.4 - 2022.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Hiroshi Yokomichi

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Determining aetiology of gastroenterological disorder and dysfunction

    2021.4 - 2022.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Hiroki Sato

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    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Establishing a new glycemic control index using ratio glycated albumin to haemoglobin A1c

    2021.4 - 2022.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Mie Mochizuki

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    Grant type:Competitive 

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  • Investigation of long-term prognoses of Japanese child-onset type 1 diabetes  Major achievement

    2021.4 - 2022.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Hiroshi Yokomichi

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    Authorship:Principal investigator  Grant type:Competitive 

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  • 診断困難な消化管運動異常症と機能性消化管疾患との境界症例の病態解明

    Grant number:20K08279  2020.4 - 2023.3

    日本学術振興会  Niigata University  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    佐藤 裕樹

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    Authorship:Coinvestigator(s) 

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  • Determining aetiology of gastroenterological disorder and dysfunction

    2020.4 - 2021.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Hiroki Sato

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Effect of delay of the onsets of diabetes and diabetic angiopathies on health life span and lifetime treatment cost

    2020.4 - 2021.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist

    Hiroshi Yokomichi

      More details

    Authorship:Principal investigator  Type of fund::Science research expense

  • Establishing a new glycemic control index using ratio glycated albumin to haemoglobin A1c

    2020.4 - 2021.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Mie Mochizuki

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Establishing a new glycemic control index using ratio glycated albumin to haemoglobin A1c

    2020.4 - 2021.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Mie Mochizuki

      More details

    Grant type:Competitive 

    researchmap

  • Determining aetiology of gastroenterological disorder and dysfunction

    2020.4 - 2021.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Hiroki Sato

      More details

    Grant type:Competitive 

    researchmap

  • Establishing a novel glycaemic control index using ratio of glycated albumin to hemoglobin A1c

    Grant number:19K10658  2019.4 - 2022.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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  • 国民健康・栄養調査結果を用いた栄養素及び食品の摂取状況の適切性の評価に関する研究(代表:横山徹爾)

    2019.4 - 2020.3

    厚生労働科学研究費  厚生労働科学研究費  循環器疾患・糖尿病等生活習慣病対策総合研究事業

    横山徹爾

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Establishing a new glycemic control index using ratio glycated albumin to haemoglobin A1c

    2019.4 - 2020.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Mie Mochizuki

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Effect of delay of the onsets of diabetes and diabetic angiopathies on health life span and lifetime treatment cost

    2019.4 - 2020.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist

    Hiroshi Yokomichi

      More details

    Authorship:Principal investigator  Type of fund::Science research expense

  • 高齢期の栄養素等摂取量の個人内・個人間変動は年齢によりどのようにかわるのか(代表:石川みどり)

    2019.4 - 2020.3

    文部科学省  科学研究費助成事業  基盤(C)

    石川みどり

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • 国民健康・栄養調査結果を用いた栄養素及び食品の摂取状況の適切性の評価に関する研究(代表:横山徹爾)

    2019.4 - 2020.3

    厚生労働科学研究費  厚生労働科学研究費  循環器疾患・糖尿病等生活習慣病対策総合研究事業

    Tetsuji Yokoyama

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    Grant type:Competitive 

    researchmap

  • Establishing a new glycemic control index using ratio glycated albumin to haemoglobin A1c

    2019.4 - 2020.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Mie Mochizuki

      More details

    Grant type:Competitive 

    researchmap

  • Effect of delay of the onsets of diabetes and diabetic angiopathies on health life span and lifetime treatment cost

    2019.4 - 2020.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist

    Hiroshi Yokomichi

      More details

    Grant type:Competitive 

    researchmap

  • 高齢期の栄養素等摂取量の個人内・個人間変動は年齢によりどのようにかわるのか(代表:石川みどり)

    2019.4 - 2020.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Midori Ishikawa

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    Grant type:Competitive 

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  • Effect of delay of the onsets of diabetes and diabetic angiopathies on health life span and lifetime treatment cost  Major achievement

    Grant number:18K17376  2018.4 - 2021.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists  Grant-in-Aid for Early-Career Scientists

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  • 高齢期の栄養素等摂取量の個人内・個人間変動は年齢によりどのようにかわるのか(代表:石川みどり)

    2018.4 - 2019.3

    文部科学省  科学研究費助成事業  基盤(C)

    石川みどり

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • 国民健康・栄養調査結果を用いた栄養素及び食品の摂取状況の適切性の評価に関する研究(代表:横山徹爾)

    2018.4 - 2019.3

    厚生労働科学研究費  厚生労働科学研究費  循環器疾患・糖尿病等生活習慣病対策総合研究事業

    横山徹爾

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • 介護予防を推進する地域づくりを戦略的に進めるための研究(代表:近藤克則)

    2018.4 - 2019.3

    厚生労働省  厚生労働科学研究費  長寿科学政策研究事業

    近藤克則

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Effect of delay of the onsets of diabetes and diabetic angiopathies on health life span and lifetime treatment cost

    2018.4 - 2019.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist

    Hiroshi Yokomichi

      More details

    Authorship:Principal investigator  Type of fund::Science research expense

  • 介護予防を推進する地域づくりを戦略的に進めるための研究(代表:近藤克則)

    2018.4 - 2019.3

    厚生労働省  厚生労働科学研究費  長寿科学政策研究事業

    Katsunori Kondo

      More details

    Grant type:Competitive 

    researchmap

  • 国民健康・栄養調査結果を用いた栄養素及び食品の摂取状況の適切性の評価に関する研究(代表:横山徹爾)

    2018.4 - 2019.3

    厚生労働科学研究費  厚生労働科学研究費  循環器疾患・糖尿病等生活習慣病対策総合研究事業

    Tetsuji Yokoyama

      More details

    Grant type:Competitive 

    researchmap

  • Effect of delay of the onsets of diabetes and diabetic angiopathies on health life span and lifetime treatment cost

    2018.4 - 2019.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist

    Hiroshi Yokomichi

      More details

    Grant type:Competitive 

    researchmap

  • 高齢期の栄養素等摂取量の個人内・個人間変動は年齢によりどのようにかわるのか(代表:石川みどり)

    2018.4 - 2019.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Midori Ishikawa

      More details

    Grant type:Competitive 

    researchmap

  • The longitudinal study on the social determinants of health of older adults in Japan

    2017.4 - 2018.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Naoki Kondo

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Clinical epidemiological study of influenza complications using administrative data

    2017.4 - 2018.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (C)

    HIroshi Yokomichi

      More details

    Authorship:Principal investigator  Type of fund::Science research expense

  • 高齢期の栄養素等摂取量の個人内・個人間変動は年齢によりどのようにかわるのか(代表:石川みどり)

    2017.4 - 2018.3

    文部科学省  科学研究費助成事業  基盤(C)

    石川みどり

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • 国民健康・栄養調査結果を用いた栄養素及び食品の摂取状況の適切性の評価に関する研究(代表:横山徹爾)

    2017.4 - 2018.3

    厚生労働科学研究費  厚生労働科学研究費  循環器疾患・糖尿病等生活習慣病対策総合研究事業

    横山徹爾

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • 介護予防を推進する地域づくりを戦略的に進めるための研究(代表:近藤克則)

    2017.4 - 2018.3

    厚生労働省  厚生労働科学研究費  長寿科学政策研究事業

    近藤克則

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Clinical epidemiological study of influenza complications using administrative data  Major achievement

    2017.4 - 2018.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (C)

    HIroshi Yokomichi

      More details

    Grant type:Competitive 

    researchmap

  • 国民健康・栄養調査結果を用いた栄養素及び食品の摂取状況の適切性の評価に関する研究(代表:横山徹爾)

    2017.4 - 2018.3

    厚生労働科学研究費  厚生労働科学研究費  循環器疾患・糖尿病等生活習慣病対策総合研究事業

    Tetsuji Yokoyama

      More details

    Grant type:Competitive 

    researchmap

  • 介護予防を推進する地域づくりを戦略的に進めるための研究(代表:近藤克則)

    2017.4 - 2018.3

    厚生労働省  厚生労働科学研究費  長寿科学政策研究事業

    Katsunori Kondo

      More details

    Grant type:Competitive 

    researchmap

  • 高齢期の栄養素等摂取量の個人内・個人間変動は年齢によりどのようにかわるのか(代表:石川みどり)

    2017.4 - 2018.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Midori Ishikawa

      More details

    Grant type:Competitive 

    researchmap

  • The longitudinal study on the social determinants of health of older adults in Japan

    2017.4 - 2018.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Naoki Kondo

      More details

    Grant type:Competitive 

    researchmap

  • 高齢期の栄養素等摂取量の個人内・個人間変動は年齢によりどのようにかわるのか(代表:石川みどり)

    2016.4 - 2020.3

    文部科学省  科学研究費助成事業  基盤(C)

    石川みどり

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Alteration in the usual intake and within- and between-individual variances of nutrients with aging in older Japanese adults

    Grant number:16K00897  2016.4 - 2020.3

    Japan Society for the Promotion of Science  National Institute of Public Health  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ishikawa Midori

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    The purpose of this study was to identify the aging-related changes in usual nutrient intake in older adults. In results, (1) It is important for nutrition management to improve the potential ability in view of the life course. (2) The usual nutrient intake decreased with age for protein (male / female) and calcium (female), but salt (female) did not change. It was also considered that within-individual variance in protein decreased with age, and in the latter stage, they ate similar foods every day, and the difference between those who ate various foods became larger. (3) In the latter-stage elderly, the subjective well-being was strongly associated with the ability to do dietary life by their selves independently.

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  • 高齢期の栄養素等摂取量の個人内・個人間変動は年齢によりどのようにかわるのか(代表:石川みどり)

    2016.4 - 2020.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Midori Ishikawa

      More details

    Grant type:Competitive 

    researchmap

  • The longitudinal study on the social determinants of health of older adults in Japan

    2016.4 - 2017.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Naoki Kondo

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • 高齢期の栄養素等摂取量の個人内・個人間変動は年齢によりどのようにかわるのか(代表:石川みどり)

    2016.4 - 2017.3

    文部科学省  科学研究費助成事業  基盤(C)

    石川みどり

      More details

    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Clinical epidemiological study of influenza complications using administrative data

    2016.4 - 2017.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (C)

    HIroshi Yokomichi

      More details

    Authorship:Principal investigator  Type of fund::Science research expense

  • 介護予防を推進する地域づくりを戦略的に進めるための研究(代表:近藤克則)

    2016.4 - 2017.3

    厚生労働省  厚生労働科学研究費  長寿科学政策研究事業

    近藤克則

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  • 介護予防を推進する地域づくりを戦略的に進めるための研究(代表:近藤克則)

    2016.4 - 2017.3

    厚生労働省  厚生労働科学研究費  長寿科学政策研究事業

    Katsunori Kondo

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    Grant type:Competitive 

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  • Clinical epidemiological study of influenza complications using administrative data

    2016.4 - 2017.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (C)

    HIroshi Yokomichi

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  • 高齢期の栄養素等摂取量の個人内・個人間変動は年齢によりどのようにかわるのか(代表:石川みどり)

    2016.4 - 2017.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Midori Ishikawa

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  • The longitudinal study on the social determinants of health of older adults in Japan

    2016.4 - 2017.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Naoki Kondo

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  • Clinical epidemiological study of influenza complications using administrative data

    Grant number:15K08730  2015.4 - 2018.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    YOKOMICHI Hiroshi, YOKOYAMA Tetsuji, MOCHIZUKI Mie

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    In Japan point-of-care tests are routinely used to diagnose influenza. We calculated the incidence of hospitalization in influenza-positive patients with acute respiratory failure, pneumonia, acute respiratory distress syndrome (ARDS), febrile seizures and encephalitis/encephalopathy. The percentage of hospitalizations by age was 2.96% of patients aged 0-1 years; 0.77% aged 2-5; 0.51% aged 6-12; 0.78% aged 13-18; 1.36% aged 19-44; 1.19% aged 45-64; and 2.21% aged 65-74. The incidence of hospitalizations from these five complications combined was highest in patients aged 0-1 years (94.3 per 10000) compared with 30.7 in those aged 2-5 years and 27.1 in those aged 65-74 years. For pneumonia, incidence was highest for patients aged 0-5 years and 65 years or more. There were statistically significant decreasing trends over the years in the incidence of hospitalizations from pneumonia and febrile seizures.

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  • Pathogenic significance of TERT promoter mutation in progression of thyroid cancer

    Grant number:15K19050  2015.4 - 2017.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    OISHI Naoki, KONDO Tetsuo, EBINA Aya, SATO Yukiko, AKAISHI Junko, HINO Rumi, YAMAMOTO Noriko, YOKOMICHI Hiroshi, MOCHIZUKI Kunio, NAKAZAWA Tadao, ITO Koichi, YABUTA Tomonori, HIROKAWA Mitsuyoshi, MIYAUCHI Akira, ISHIKAWA Yuichi, KATOH Ryohei

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    We examined genetic alterations in coexisting thyroid papillary carcinoma (PC) and anaplastic carcinoma (AC) to elucidate risk factors for anaplastic transformation. In the series of PC-derived ACs, BRAF and TERT promoter mutations were the most frequent alternations. These two mutations occurred prior to anaplastic transformation. Furthermore, using multivariate analysis with control PCs, we identified TERT promoter mutation to be an independent risk factor for anaplastic transformation. We also demonstrated PIK3CA mutations and aberrant expression of p53, TTF-1 and SWI/SNF proteins in a subset of PC-derived AC with temporally heterogeneous pattern of acquisition. By showing that TERT is highly associated with anaplastic transformation, it opens the possibility of stratifying PC patients for therapy using TERT promoter mutations.

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  • The longitudinal study on the social determinants of health of older adults in Japan

    2015.4 - 2016.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Naoki Kondo

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    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • Clinical epidemiological study of influenza complications using administrative data

    2015.4 - 2016.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (C)

    HIroshi Yokomichi

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    Authorship:Principal investigator  Type of fund::Science research expense

  • 介護予防を推進する地域づくりを戦略的に進めるための研究(代表:近藤克則)

    2015.4 - 2016.3

    厚生労働省  厚生労働科学研究費  長寿科学政策研究事業

    近藤克則

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    Authorship:Coinvestigator(s)  Type of fund::Science research expense

  • 介護予防を推進する地域づくりを戦略的に進めるための研究(代表:近藤克則)

    2015.4 - 2016.3

    厚生労働省  厚生労働科学研究費  長寿科学政策研究事業

    Katsunori Kondo

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  • Clinical epidemiological study of influenza complications using administrative data

    2015.4 - 2016.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (C)

    HIroshi Yokomichi

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  • The longitudinal study on the social determinants of health of older adults in Japan

    2015.4 - 2016.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Scientific Research (C)

    Naoki Kondo

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  • Development of Statistical Methods to Estimate Usual Intake Distribution of Nutrients

    2014.4 - 2015.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (B)

    Hiroshi Yokomichi, Zentaro Yamagata, Toshiro Tango, Tetsuji Yokoyama, Masako Fujii

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    Authorship:Principal investigator  Type of fund::Science research expense

  • Development of Statistical Methods to Estimate Usual Intake Distribution of Nutrients

    2014.4 - 2015.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (B)

    Hiroshi Yokomichi, Zentaro Yamagata, Toshiro Tango, Tetsuji Yokoyama, Masako Fujii

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  • The longitudinal study on the social determinants of health of older adults in Japan

    Grant number:25253052  2013.4 - 2018.3

    Japan Society for the Promotion of Science  The University of Tokyo  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)  Grant-in-Aid for Scientific Research (A)

    KONDO NAOKI

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    We created 3-wave panel data using the survey data taken in 2010, 2013, and 2016 based on the Japan Gerontological Evaluation Study. The study followed up more than 100 thousand older adults in Japan every three year. We merged the panel data with national death registry and municipal data of public long-term care insurance payment and certification. With this data we could evaluated the trajectories in functional capacity and long-term care service utilization. Using these data we conducted various empirical analyses on the social determinants of health of Japanese older adults and published over 100 original articles. For example, the health effects of community social capital varied across individual socioeconomic statuses and the onset of natural disasters.

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  • Development of Statistical Methods to Estimate Usual Intake Distribution of Nutrients

    2013.4 - 2014.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (B)

    Hiroshi Yokomichi, Zentaro Yamagata, Toshiro Tango, Tetsuji Yokoyama, Masako Fujii

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    Authorship:Principal investigator  Type of fund::Science research expense

  • Development of Statistical Methods to Estimate Usual Intake Distribution of Nutrients

    2013.4 - 2014.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (B)

    Hiroshi Yokomichi, Zentaro Yamagata, Toshiro Tango, Tetsuji Yokoyama, Masako Fujii

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    Authorship:Principal investigator  Type of fund::Science research expense

  • Development of Statistical Methods to Estimate Usual Intake Distribution of Nutrients

    2013.4 - 2014.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (B)

    Hiroshi Yokomichi, Zentaro Yamagata, Toshiro Tango, Tetsuji Yokoyama, Masako Fujii

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    Grant type:Competitive 

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  • Development of Statistical Methods to Estimate Usual Intake Distribution of Nutrients

    2013.4 - 2014.3

    Ministry of Education, Culture, Sports, Science, and Technology  KAKENHI(Grants-in-Aid for Scientific Research)  Grant-in-Aid for Young Scientist (B)

    Hiroshi Yokomichi, Zentaro Yamagata, Toshiro Tango, Tetsuji Yokoyama, Masako Fujii

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  • Development of Statistical Methods to Estimate Usual Intake Distribution of Nutrients  Major achievement

    Grant number:24790614  2012.4 - 2015.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    YOKOMICHI Hiroshi, YAMAGATA Zentaro, TANGO Toshiro, YOKOYAMA Tetsuji, FUJII Masako

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    To prevent metabolic syndrome, cardiac diseases, stroke and cancer, it is important to know the true usual amounts of certain nutrients in each individual’s diet; however, the true values are never available. Similarly, administrators and researchers never know the true proportion of the people who are at high risk for nutritional excesses in any given region. The aim of this project was to develop a statistical method to identify the individuals and proportion of individuals at high risk of nutritional excesses.
    A statistical methodology for determining the individuals and proportion at a high risk of nutritional excesses has comprised mathematical models. My computer program that uses this methodology has been applied to nationwide Japanese nutritional data. The results of this project have been published in an overseas journal and will be utilised by domestic and foreign authorities.

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  • Japan Environment and Children’s Study

    2010

    Ministry of the Environment 

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Papers

  • A parent-rating scale of postpartum depression: Maternity-monitoring scale by parents (MMSP) Reviewed

    Yoshiaki Ohashi, Miho Shoji, Kaori Hanawa, Hiroshi Yokomichi, Hiroki Ishiguro

    JOURNAL OF PSYCHIATRIC RESEARCH   171   197 - 206   2024.3( ISSN:0022-3956 )

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    Language:English   Publishing type:Research paper (scientific journal)  

    File: J Psychiatr Res 2024 Ohashi Y MMSP of of postpartum depression.pdf

    DOI: 10.1016/j.jpsychires.2024.01.033

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  • Association between filaggrin gene mutations and the clinical features of molluscum contagiosum: The Yamanashi Adjunct Study of the Japan Environment and Children's Study Reviewed

    Reiji Kojima, Kunio Miyake, Ryoji Shinohara, Megumi Kushima, Hideki Yui, Sanae Otawa, Sayaka Horiuchi, Hiroshi Yokomichi, Yuka Akiyama, Tadao Ooka, Zentaro Yamagata

    JOURNAL OF DERMATOLOGY   Online first   2024.2( ISSN:0385-2407 )

  • Safety of intranasal insulin administration in patients undergoing cardiovascular surgery: An open-label, nonrandomized, dose-escalation study Reviewed International coauthorship

    Yosuke Nakadate, Akiko Kawakami, Takeshi Oguchi, Keisuke Omiya, Hiroyuki Nakajima, Hiroshi Yokomichi, Hiroaki Sato, Thomas Schricker, Takashi Matsukawa

    JTCVS Open   17   172 - 182   2024.2( ISSN:2666-2736 )

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.xjon.2023.11.020

  • Mortality in childhood-onset type 1 diabetes mellitus with onset between 1959 and 1996: A population-based study in Hokkaido, Japan Reviewed Major achievement

    Nobuo Matsuura, Hiroshi Yokomichi, Yoshiya Ito, Shigeru Suzuki, Mie Mochizuki

    Diabetology International   15   262 - 269   2024.1( ISSN:2190-1678 )

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER JAPAN KK  

    File: Diabetol Int 2024 Matsuura N Mortality in type 1 diabetes in Japan.pdf

    DOI: 10.1007/s13340-023-00688-0

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  • Antibiotic prescription for outpatients with influenza and subsequent hospitalisation: A cohort study using insurance data Reviewed International coauthorship Major achievement

    Hiroshi Yokomichi, Mie Mochizuki, Joseph Jonathan Lee, Reiji Kojima, Sayaka Horiuchi, Tadao Ooka, Zentaro Yamagata

    Influenza and Other Respiratory Viruses   17 ( 11 )   e13221   2023.11( ISSN:1750-2640 )

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/irv.13221

    DOI: 10.1111/irv.13221

  • Achalasia phenotypes and prediction of per-oral endoscopic myotomy outcomes using machine learning. Reviewed

    Kazuya Takahashi, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Kenta Hamada, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Shuji Terai, Haruhiro Inoue

    Digestive Endoscopy   Online   2023.10( ISSN:0915-5635 )

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    OBJECTIVES: High-resolution manometry (HRM) and esophagography are used for achalasia diagnosis; however, achalasia phenotypes combining esophageal motility and morphology are unknown. Moreover, predicting treatment outcomes of per-oral endoscopic myotomy (POEM) in treatment-naïve patients remains an unmet need. METHODS: In this multicenter cohort study, we included 1,824 treatment-naïve patients diagnosed with achalasia. In total, 1,778 patients underwent POEM. Clustering by machine learning (ML) was conducted to identify achalasia phenotypes using patients' demographic data, including age, sex, disease duration, body mass index, and HRM/esophagography findings. ML models were developed to predict persistent symptoms (Eckardt score ≥3) and reflux esophagitis (RE) (Los Angeles grades A to D) after POEM. RESULTS: ML identified three achalasia phenotypes: phenotype 1, type I achalasia with a dilated esophagus (n=676; 37.0%); phenotype 2, type II achalasia with a dilated esophagus (n=203; 11.1%); phenotype 3, late-onset type I-III achalasia with a non-dilated esophagus (n=619, 33.9%). Types I and II achalasia in phenotypes 1 and 2 exhibited different clinical characteristics from those in phenotype 3, implying different pathophysiologies within the same HRM diagnosis. A predictive model for persistent symptoms exhibited an area under the curve (AUC) of 0.70. Pre-POEM Eckardt score ≥6 was the greatest contributing factor for persistent symptoms. The AUC for post-POEM RE was 0.61. CONCLUSION: Achalasia phenotypes combining esophageal motility and morphology indicated multiple disease pathophysiologies. ML helped develop an optimal risk stratification model for persistent symptoms with novel insights into treatment resistance factors.

    DOI: 10.1111/den.14714

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  • Obesity as a potential risk factor for stillbirth: The Japan Environment and Children's Study Reviewed

    Satoshi Shinohara, Ryoji Shinohara, Reiji Kojima, Sayaka Horiuchi, Sanae Otawa, Megumi Kushima, Kunio Miyake, Hideki Yui, Tadao Ooka, Yuka Akiyama, Hiroshi Yokomichi, Zentaro Yamagata

    Preventive Medicine Reports   35   102391 - 102391   2023.10( ISSN:2211-3355 )

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    The relationship between high body mass index (BMI) >25 kg/m2 and risk for stillbirth in the Japanese population remains unclear. This study aimed to estimate the impact of maternal obesity on the risk of stillbirth in a Japanese population. This prospective cohort study used data from the Japan Environment and Children's Study, which recruited pregnant individuals between 2011 and 2014. A total of 93,772 fetuses were considered eligible for inclusion in this study. Stillbirth (fetal death before or during labor at ≥22 completed weeks of gestation) rates were compared among four pre-pregnancy BMI groups: underweight (<18.5 kg/m2), reference (18.5 to <25.0 kg/m2), overweight (25.0 to <30.0 kg/m2), and obese (≥30.0 kg/m2). The association between pre-pregnancy BMI and the risk of stillbirth was estimated using multiple logistic regression analyses. The overall stillbirth incidence was 0.33% (305/93,722). Compared with the reference group, the risk of stillbirth was significantly higher in the overweight group (adjusted odds ratio [aOR]: 1.55; 95% confidence interval [CI]: 1.08-2.23) and the obese group (aOR: 2.60; 95% CI: 1.59-4.24). The overall incidence of early stillbirth (i.e., <28 weeks) was 0.17% (155/93,722). Similarly, after adjusting for potential confounding factors, the risk of early stillbirth was significantly higher in the obese group (aOR: 4.33; 95% CI: 2.44-7.70). Increased maternal BMI was associated with an increased risk of stillbirth in the Japanese population. Therefore, counselling women planning for pregnancy on the importance of an appropriate pre-pregnancy BMI to minimize the risk of stillbirth is important.

    DOI: 10.1016/j.pmedr.2023.102391

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  • Analysis of physical and non-physical factors associated with individual water consumption using a hierarchical linear model before and after an earthquake in a region with insufficient water supply Reviewed International coauthorship

    Yuri Ito, Hiroshi Yokomichi, Sadhana Shrestha, Anthony S. Kiem, Naoki Kondo, Kei Nishida

    Journal of Water Sanitation and Hygiene for Development   13 ( 9 )   687 - 698   2023.9( ISSN:2043-9083  eISSN:2408-9362 )

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:IWA Publishing  

    Abstract

    In regions suffering from water scarcity, residents commonly employ several coping strategies such as the use of multiple water sources, water storage and water sharing and borrowing. This study applies a hierarchical linear regression model to investigate the physical (i.e. water source and supply time) and non-physical (i.e. number of families, wealth status, education for household head, house ownership, water treatment and community involvement) factors associated with individual water consumption throughout the Kathmandu Valley, Nepal. During the baseline period (dry season before the 2015 Gorkha earthquake), the average water consumption was 91 litre/capita/day (LPCD) but there was a regional disparity in water consumption, ranging from 16 to 158 LPCD. The statistical analysis indicated that households using many water sources consumed more water regardless of the supply area even in an emergency. In addition, households with many family members used less water per person. During emergencies, households participating in the local community were found to consume more water than households not participating in the community, especially when the water being used was managed by the community.

    DOI: 10.2166/washdev.2023.059

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  • Association of influenza vaccination or influenza virus infection history with subsequent infection risk among children: The Japan Environment and Children's Study (JECS). Reviewed Major achievement

    Hiroshi Yokomichi, Mie Mochizuki, Sayaka Horiuchi, Megumi Kushima, Ryoji Shinohara, Reiji Kojima, Tadao Ooka, Yuka Akiyama, Kunio Miyake, Sanae Otawa, Zentaro Yamagata

    Preventive Medicine   173   107599 - 107599   2023.8( ISSN:0091-7435 )

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    We measured the association between history of influenza vaccination by age 2 years and influenza virus (IFV) infection at ages 3 and 4 years by relative risk reduction. We also examined the association between history of IFV infection by age 2 years and recurrent IFV infection at age 3 years. This study included 73,666 children from a large Japanese birth cohort. Among children vaccinated never, once or twice when aged under 2 years, 16.0%, 10.8% and 11.3%, respectively, had been infected with IFV by age 3 years, and 19.2%, 14.5% and 16.0%, respectively, by age 4 years. Compared with no history of influenza vaccination, vaccination at ages 1 and/or 2 years reduced the risk of IFV infection at age 3 by 30%-32% and at age 4 by 17%-24%. The relative risk of recurrent IFV infection at ages 3 and 4 years increased in proportion to the number of prior infections by age 2. One-season-prior influenza vaccination history reduced the IFV infection risk at age 3 years by 25%-42%. Influenza vaccination most effectively protected children at age 3 who lacked older sibling(s) and did not attend nursery school. One-season-prior IFV infection increased the relative risk of recurrent infection at age 3 years (1.72-3.33). In conclusion, influenza vaccination-induced protection may partly extend to the next season. Owing to the relative risk reduction by influenza vaccination and the increased relative risk of IFV infection from prior-season infection, annual influenza vaccination is recommended.

    DOI: 10.1016/j.ypmed.2023.107599

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  • Maternal dietary fiber intake during pregnancy and child development: the Japan Environment and Children's Study Reviewed

    Kunio Miyake, Sayaka Horiuchi, Ryoji Shinohara, Megumi Kushima, Sanae Otawa, Hideki Yui, Yuka Akiyama, Tadao Ooka, Reiji Kojima, Hiroshi Yokomichi, Kazuki Mochizuki, Zentaro Yamagata

    Frontiers in Nutrition   10   1203669   2023.7( ISSN:2296-861X  eISSN:2296-861X )

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    Background

    Animal studies have shown that maternal low-fiber diets during pregnancy may impair brain development and function in offspring, but this has not been validated by epidemiological studies. The aim of this study was to investigate the link between maternal dietary fiber intake during pregnancy and neurodevelopmental delay in offspring using a large birth cohort.

    Methods

    A total of 76,207 mother-infant pairs were analyzed using data from the Japan Environment and Children's Study, a nationwide prospective cohort study. Maternal dietary fiber intake was estimated using the food frequency questionnaire in mid-pregnancy. Maternal dietary fiber intake was adjusted for energy and classified into quintiles. Developmental delay was assessed in five domains using the Japanese version of the Ages and Stages Questionnaire, Third Edition at the age of 3 years. The logistic regression analysis was performed to estimate the odds ratio (OR) and 95% confidence interval (CI) for the link between dietary fiber intake during pregnancy and developmental delay at the age of 3 years.

    Results

    The lowest intake group of total dietary fiber had a higher risk of delayed communication [adjusted OR (aOR), 1.51; 95% CI, 1.32–1.74], fine motor (aOR, 1.45; 95% CI, 1.32–1.61), problem-solving (aOR, 1.46; 95% CI, 1.32–1.61), and personal-social skills (aOR, 1.30; 95% CI, 1.12–1.50) than did the highest intake group. An analysis that excluded the effects of insufficient folic acid intake during pregnancy also showed a similar trend.

    Conclusion

    This study showed that maternal dietary fiber deficiency during pregnancy might influence an increased risk of neurodevelopmental delay in offspring.

    DOI: 10.3389/fnut.2023.1203669

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  • A nationwide, prospective, cohort study on exogenous oxytocin and delays in early child development: the Japan environment and children's study Reviewed

    Satoshi Shinohara, Sayaka Horiuchi, Ryoji Shinohara, Sanae Otawa, Megumi Kushima, Kunio Miyake, Hideki Yui, Reiji Kojima, Tadao Ooka, Yuka Akiyama, Hiroshi Yokomichi, Zentaro Yamagata

    EUROPEAN JOURNAL OF PEDIATRICS   182   4059 - 4068   2023.7( ISSN:0340-6199  eISSN:1432-1076 )

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    Although it remains debatable, exogenous oxytocin, commonly used for labour induction and augmentation, reportedly increases risks of neurodevelopment delay, attention-deficit/hyperactivity disorder, and autism spectrum disorder among children prenatally exposed to exogenous oxytocin. However, only few studies have objectively examined exogenous oxytocin's impact on early childhood development through scoring evaluations. This study investigated the association between exogenous oxytocin exposure and neurodevelopment in 3-year-old children using the Ages and Stages Questionnaires, Third Edition. In this nationwide prospective cohort study, we extracted data from 104,062 foetal records regarding exogenous oxytocin use during labour from the Japan Environment and Children's Study. Participants completed questionnaires throughout the pregnancy and postpartum periods. Outcomes comprised the developmental status less than each cut-off value for the five domains of the Ages and Stages Questionnaire, Third Edition. We conducted multivariable logistic regression analyses on the data of 55,400 children after controlling for confounders. Among the 55,400 included women, 19.0% (n = 10,506) used exogenous oxytocin during labour and 81.0% (n = 44,894) did not. Children exposed to exogenous oxytocin showed no significantly increased risk of developmental delay in any domain (communication: odds ratio [OR] 1.04, 95% confidence interval [CI] 0.92-1.16; gross motor: OR 0.97, 95% CI 0.87-1.08; fine motor: OR 1.00, 95% CI 0.92-1.09; problem-solving: OR 1.02, 95% CI 0.94-1.11; personal-social: OR 0.91, 95% CI 0.80-1.03).Conclusion: Exogenous oxytocin for labour induction did not adversely affect early childhood development. Further studies accounting for the degree of exogenous oxytocin exposure are required to confirm these results.

    DOI: 10.1007/s00431-023-05079-w

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  • Clinical characteristics of absent contractility and ineffective esophageal motility: a multicenter study in Japan Reviewed

    Yuichiro Ikebuchi, Hiroki Sato, Haruo Ikeda, Hirofumi Abe, Masaki Ominami, Junya Shiota, Chiaki Sato, Hisashi Fukuda, Ryo Ogawa, Tetsuya Tatsuta, Hiroshi Yokomichi, Hajime Isomoto, Haruhiro Inoue

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   38 ( 11 )   1926 - 1933   2023.6( ISSN:0815-9319 )

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    BACKGROUND AND AIM: Absent contractility (AC) and ineffective esophageal motility (IEM) are esophageal hypomotility disorders diagnosed using high-resolution manometry (HRM). Patient characteristics and disease course of these conditions and differential diagnosis between AC and achalasia are yet to be elucidated. METHODS: A multicenter study involving 10 high-volume hospitals was conducted. Starlet HRM findings were compared between AC and achalasia. Patient characteristics including underlying disorders and disease courses were analyzed in AC and IEM. RESULTS: Fifty-three patients with AC and 92 with IEM were diagnosed, while achalasia was diagnosed in 1784 patients using the Chicago classification v3.0 (CCv3.0). The cut-off integrated relaxation pressure (IRP) value at 15.7 mmHg showed maximum sensitivity (0.80) and specificity (0.87) for differential diagnosis of AC from type I achalasia. While most ACs were based on systemic disorders such as scleroderma (34%) and neuromuscular diseases (8%), 23% were sporadic cases. The symptom severity of AC was not higher than that of IEM. Regarding the diagnosis of IEM, the more stringent CCv4.0 excluded 14.1% of IEM patients than the CCv3.0, although patient characteristics did not change. In patients with the hypomotile esophagus, concomitance of reflux esophagitis was associated with low distal contractile integral and IRP values. AC and IEM transferred between each other, paralleling with the underlying disease course, although no transition to achalasia was observed. CONCLUSION: A successful determination of the optimal cut-off IRP value was achieved using the starlet HRM system to differentiate AC and achalasia. Follow-up HRM is also useful for differentiating AC from achalasia. Symptom severity may depend on underlying diseases instead of hypomotility severity.

    DOI: 10.1111/jgh.16268

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  • 小児の夜間を含む尿禁制獲得時期に関与する因子 縦断的コホート研究(エコチル調査より) The Yamanashi Adjunct Study of the Japan Environment and Children's study Reviewed

    志村 寛史, 土屋 幸子, 神田 美恵, 土田 哲司, 垣渕 由岐子, 澤田 智史, 小田和 早苗, 堀内 清華, 久島 萌, 三宅 邦夫, 秋山 有佳, 大岡 忠生, 小島 令嗣, 由井 秀樹, 横道 洋司, 篠原 亮次, 山縣 然太朗, 三井 貴彦

    日本小児泌尿器科学会雑誌   32 ( 1 )   62 - 67   2023.6( ISSN:1341-0784 )

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  • Retrospective analysis on gestational weight gain in twin pregnancies with favorable perinatal outcomes: The Japan Environment and Children's Study (JECS) Reviewed

    Satoko TAKAOKA, Yasue KOBAYASHI, Ryoji SHINOHARA, Sayaka HORIUCHI, Megumi KUSHIMA, Sanae OTAWA, Hiroshi YOKOMICHI, Kunio MIYAKE, Reiji KOJIMA, Yuka AKIYAMA, Tadao OOKA, Hideki YUI, Zentaro YAMAGATA

    Journal of Japan Academy of Midwifery   37 ( 3 )   219 - 230   2023.5( ISSN:0917-6357 )

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    DOI: 10.3418/jjam.JJAM-2022-0043

  • Multiple pregnancy as a potential risk factor for postpartum depression: The Japan Environment and Children's Study Reviewed

    Shinohara S, Horiuchi S, Shinohara R, Otawa S, Kushima M, Miyake K, Yui H, Kojima R, Ooka T, Akiyama Y, Yokomichi H, Yamagata Z

    JOURNAL OF AFFECTIVE DISORDERS   329   218 - 224   2023.5( ISSN:0165-0327 )

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    File: 1-s2.0-S0165032723002458-main.pdf

    DOI: 10.1016/j.jad.2023.02.088

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  • Interpregnancy weight change as a potential risk factor for large-for-gestational-age infants: the Japan Environment and Children’s Study Reviewed

    Satoshi Shinohara, Sayaka Horiuchi, Ryoji Shinohara, Sanae Otawa, Megumi Kushima, Kunio Miyake, Hideki Yui, Reiji Kojima, Tadao Ooka, Yuka Akiyama, Hiroshi Yokomichi, Zentaro Yamagata, Japan Environment and Children’s Study Group

    Journal of Maternal-Fetal & Neonatal Medicine   36 ( 1 )   2209251   2023.5( ISSN:1476-7058 )

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    DOI: 10.1080/14767058.2023.2209251

    DOI: 10.1080/14767058.2023.2209251

  • グルコアルブミン/HbA1c比は長期間安定した各個人固有のglycation gapの指標である Reviewed

    武者 育麻, 望月 美恵, 國米 崇秀, 赤塚 淳弥, 小林 浩司, 鈴木 滋, 小山 さとみ, 菅原 大輔, 小林 基章, 横道 洋司, 松浦 信夫, 杉原 茂孝, 菊池 透, 雨宮 伸

    糖尿病   66 ( Suppl.1 )   214 - 214   2023.4( ISSN:0021-437X  eISSN:1881-588X )

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  • Impact of peroral endoscopic myotomy on high-resolution manometry findings and their association with the procedure’s outcomes Reviewed

    Yoshitaka Hata, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Akio Shiwaku, Junya Shiota, Chiaki Sato, Masaki Ominami, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Eikichi Ihara, Haruhiro Inoue

    GASTROINTESTINAL ENDOSCOPY   97 ( 4 )   673 - 683   2023.4( ISSN:0016-5107 )

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    DOI: 10.1016/j.gie.2022.10.039 Get rights and content

    DOI: 10.1016/j.gie.2022.10.039 Get rights and content

  • 小児期発症1型糖尿病児は成人して過体重(3型糖尿病)に移行するか?

    松浦 信夫, 伊藤 善也, 母坪 智行, 鈴木 滋, 横道 洋司, 望月 美恵, 吉岡 成人

    糖尿病   66 ( Suppl.1 )   191 - 191   2023.4( ISSN:0021-437X  eISSN:1881-588X )

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  • Association of maternal monocyte and neutrophil counts with hypertensive disorders of pregnancy: The Japan Environment and Children’s Study (JECS) Reviewed

    Kazuki Mochizuki, Shiori Ishiyama, Ryoji Shinohara, Kunio Miyake, Megumi Kushima, Reiji Kojima, Sayaka Horiuchi, Sanae Otawa, Tadao Ooka, Yuka Akiyama, Hiroshi Yokomichi, Zentaro Yamagata

    Scientific Reports   14 ( 1 )   7248   2023.3(  eISSN:2045-2322 )

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    Abstract

    Hypertensive disorders of pregnancy (HDP) increase the risk of preterm births and cesarean delivery. This study aimed to investigate whether maternal blood leukocyte, monocyte, or neutrophil counts in the first trimester are related to the development of HDP. Data were collected from the Japan Environment and Children’s Study, a large birth cohort study (n = 38,194) that recruited pregnant women in 15 Regional Centers across Japan (from January 2011 to March 2014). The odds ratios (ORs) for mild/severe HDP according to the cut-off value of leukocyte/neutrophil/monocyte counts by the receiver operating characteristic curve showed high ORs. Furthermore, pregnant women with the highest quartiles of leukocyte and monocyte counts had higher adjusted ORs (aORs) for mild (leukocyte: aOR = 1.27, 95% confidence interval [CI]: 1.02–1.58; monocyte: aOR = 1.30, 95% CI 1.04–1.63) and severe HDP (leukocyte: aOR = 1.51, 95% CI 1.08–2.13; monocyte: aOR = 1.44, 95% CI 1.03–2.01) compared with those with the lowest quartiles of those counts. In addition, pregnant women with the highest neutrophil counts had higher aOR for mild HDP (aOR = 1.26, 95% CI 1.02–1.56) compared with those with the lowest count. In conclusion, high leukocyte and monocyte counts in the first trimester are associated with the development of HDP. Thus, they may be used to predict subsequent HDP.

    DOI: 10.22541/au.167915051.14233222/v1

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  • Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study Reviewed

    Miyake K, Kushima M, Shinohara R, Horiuchi S, Otawa S, Akiyama Y, Ooka T, Kojima R, Yokomichi H, Yamagata Z, JECS Group

    Scientific Reports   13 ( 1 )   3234 - 3234   2023.2( ISSN:2045-2322 )

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    The association between maternal pre-pregnancy smoking status and asthma risk is unclear. This study aimed to investigate the association between pre- and post-pregnancy maternal smoking status and bronchial asthma at 3 years of age in a large birth cohort. Data of 75,411 mother-child pairs from the Japan Environment and Children's Study (JECS) were analysed using multivariate logistic regression analysis. Overall, 7.2% of the children had bronchial asthma. The maternal smoking status before childbirth was as follows: Never = 60.0%, Quit before recognising current pregnancy = 24.1%, Quit after finding out about current pregnancy = 12.3%, and Still smoking = 3.6%. Children of mothers who sustained smoking during pregnancy had an increased risk of bronchial asthma at 3 years of age even after adjusting for pre- and postnatal covariates (adjusted odds ratio [aOR] 1.34, 95% confidence interval [CI] 1.15-1.56). Children of mothers who quit before (aOR 1.09, 95% CI 1.02-1.18) or after (aOR 1.11, 95% CI 1.01-1.23) recognising the current pregnancy had an increased risk of bronchial asthma at 3 years of age. Maternal smoking throughout pregnancy and smoking exposure pre-pregnancy or in early pregnancy increases the risk of bronchial asthma in children.

    DOI: 10.1038/s41598-023-30304-9

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  • Season of birth and atopic dermatitis in early infancy: Results from the Japan Environment and Children’s Study Reviewed

    Tsuchida A, Itazawa T, Matsumura K, Yokomichi H, Yamagata Z, Adachi Y, Inadera H

    BMC Pediatrics   23   78   2023.2( ISSN:1471-2431 )

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    DOI: https://doi.org/10.1186/s12887-023-03878-6

    Other Link: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-023-03878-6

  • 妊婦のストレスイベントと子どもの3歳時のアレルギー疾患との関連 エコチル調査より

    小島 令嗣, 篠原 亮次, 久島 萌, 堀内 清華, 小田和 早苗, 横道 洋司, 秋山 有佳, 大岡 忠生, 三宅 邦夫, 山縣 然太朗

    Journal of Epidemiology   33 ( Suppl.1 )   147 - 147   2023.2( ISSN:0917-5040  eISSN:1349-9092 )

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  • 小児期発症1型糖尿病患者の死亡・透析アウトカム 小児IDDM北海道登録

    横道 洋司, 望月 美恵, 伊藤 善也, 鈴木 滋, 山縣 然太朗, 松浦 信夫

    Journal of Epidemiology   33 ( Suppl.1 )   85 - 85   2023.2( ISSN:0917-5040  eISSN:1349-9092 )

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  • Effect of birth season on allergic rhinitis and cedar pollinosis considering allergen and vitamin D exposure: the Japan Environment and Children’s Study (JECS) Reviewed

    Kojima R, Shinohara R, Kushima M, Horiuchi S, Otawa S, Miyake K, Yokomichi H, Akiyama Y, Ooka T, Yamagata Z

    ALLERGOLOGY INTERNATIONAL   in Press   2023.1( ISSN:1323-8930 )

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    BACKGROUND: The relationship between the season of birth, allergen sensitization, and allergic rhinitis have been inconsistent, and there are no studies that simultaneously consider vitamin D and allergen exposure. This study aimed to determine the associations between the season of birth, house dust mite (HDM) and Japanese cedar pollen (JCP) sensitization, and allergic rhinitis and pollinosis, while taking vitamin D levels and allergen exposure into account. METHODS: This study included 4323 participants in the Sub-Cohort Study of the Japan Environment and Children's Study. A logistic regression model was used to analyze the association between the season of birth and sensitization to JCP or HDM (judged by specific immunoglobulin E) at age 2 and allergic rhinitis or pollinosis at age 3, adjusted for HDM or JCP exposure and vitamin D levels with potential confounders. RESULTS: Participants born in spring or summer were more likely to have pollinosis than were those born in winter (adjusted odds ratio [aOR]: 2.08, 95% confidence interval [CI]: 1.13-3.82 for spring; aOR: 1.89, 95% CI: 1.03-3.47 for summer). Participants born in summer were more likely to have HDM sensitization than were those born in winter (Der p 1, aOR: 1.53, 95% CI: 1.10-2.15; Der f 1, aOR: 1.44, 95% CI: 1.03-2.01). Exposure to JCP and HDM were associated with pollinosis and HDM sensitization, respectively. CONCLUSIONS: Spring and summer births were associated with the development of pollinosis, and summer birth was associated with HDM sensitization, even when vitamin D and allergen exposure were considered. Further studies on mechanisms other than vitamin D and allergen exposure are required.

    File: Kojima2023 pollinosis.pdf

    DOI: 10.1016/j.alit.2023.01.003

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  • Appropriate procedures to encourage children to evaluate blood collection in a positive way Reviewed

    Yui H, Otawa S, Horiuchi S, Kushima M, Shinohara R, Kojima1 R, Akiyama Y, Ooka1 T, Miyake K, Yokomichi H, Yamagata Z, The Yamanashi adjunct study of JECS

        6 ( 1 )   1 - 10   2023.1( ISSN:2398-8835  eISSN:2398-8835 )

  • Maternal protein intake in early pregnancy and child development at age 3 years Reviewed

    Miyake K, Mochizuki K, Kushima M, Shinohara R, Horiuchi S, Otawa S, Akiyama Y, Ooka T, Kojima R, Yokomichi H, Yamagata Z, JECS Group

    PEDIATRIC RESEARCH   Online first   1 - 8   2023.1( ISSN:0031-3998 )

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    DOI: https://doi.org/10.1038/s41390-022-02435-8

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  • Infantile peanut introduction and peanut allergy in regions with a low prevalence of peanut allergy: the Japan Environment and Children’s Study (JECS) Reviewed

    Reiji Kojima, Ryoji Shinohara, Megumi Kushima, Hideki Yui, Sanae Otawa, Sayaka Horiuchi, Kunio Miyake, Hiroshi Yokomichi, Yuka Akiyama, Tadao Ooka, Zentaro Yamagata

    Journal of Epidemiology   2023( ISSN:0917-5040  eISSN:1349-9092 )

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    DOI: 10.2188/jea.je20230210

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  • Influence of the mental health status on the healthy lifespan of elderly residents in community: Y-HALE study Reviewed

    Ikeya M, Yokomichi H, Yamagata Z

    Japanese Journal of Geriatric Psychiatry   33 ( 11 )   1199 - 1210   2022.11( ISSN:0915-6305 )

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    Other Link: https://mol.medicalonline.jp/library/journal/download?GoodsID=aj2rsizd/2022/003311/013&name=1199-1210j&UserID=133.23.3.163

  • Exposure to house dust mite allergen and endotoxin in early life and sensitization and allergic rhinitis: The JECS Reviewed

    Kojima R, Shinohara R, Kushima M, Horiuchi S, Otawa S, Miyake K, Yokomichi H, Akiyama Y, Ooka T, Yamagata Z, JECS Group

    International Journal of Environmental Research and Public Health   19 ( 22 )   14796 - 14796   2022.11( ISSN:1660-4601  eISSN:1660-4601 )

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    The association between endotoxin and allergic rhinitis (AR) is not conclusive. The aim of this study was to determine the association between endotoxin and house dust mite (HDM) allergens in dust, and HDM sensitization and AR among Japanese infants. This study included 4188 participants in the Sub-Cohort Study of the Japan Environment and Children’s Study. Dust was collected from children’s mattresses at age 18 months and endotoxin and HDM allergen levels were measured. A logistic regression model was used to analyze the association between endotoxin or HDM allergen and the sensitization to HDM (specific-IgE) at age 2 and AR at age 3. The median (interquartile range) endotoxin level was 375.1(186.9–826.5) EU/m2 and the Der 1 (Der p 1 + Der f 1) level was 51.2 (14.8–168.6) ng/m2. There were significant positive associations between endotoxin and HDM sensitization (Der f 1, adjusted odds ratio [aOR] quartile [Q] 4 vs. Q1, 1.44, 95% CI, 1.04–2.00; Der p 1, aOR Q4 vs. Q1, 1.56, 95% CI, 1.12–2.16). There were also significant positive associations between Der 1 exposure and HDM sensitization (Der f 1, aOR Q3 vs. Q1, 1.75, 95% CI, 1.26–2.44; aOR Q4 vs. Q1, 2.98, 95% CI, 2.15–4.13; Der p 1, aOR Q3 vs. Q1, 1.91, 95% CI, 1.37–2.66; aOR Q4 vs. Q1, 2.91, 95% CI, 2.09–4.05). There were, however, no associations between endotoxin or Der 1 and AR. In the population residing mostly in non-farming settings, both endotoxin and HDM allergens in dust were associated with an increased risk of HDM allergen sensitization, but not with AR.

    File: ijerph-19-14796-v2.pdf

    DOI: 10.3390/ijerph192214796

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  • Risks of refractory chest pain after peroral endoscopic myotomy in achalasia-related esophageal motility disorders: short-term results from a multicenter study in Japan Reviewed

    Fukuda H, Sato H, Fujiyoshi Y, Abe H, Okada H, Shiota J, Sato C, Sakae H, Ominami M, Hata Y, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Yamamoto H, Inoue H

    GASTROINTESTINAL ENDOSCOPY   96 ( 4 )   620 - 629   2022.11( ISSN:0016-5107 )

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    DOI: 10.1016/j.gie.2022.04.1347

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  • Impact of peroral endoscopic myotomy on high-resolution manometry findings and their association with the procedure’s outcomes Reviewed

    Hata Y, Sato H, Shimamura Y, Abe H, Shiwaku A, Shiota J, Sato C, Ominami M, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Ihara E, Inoue H

    GASTROINTESTINAL ENDOSCOPY   Online first ( 4 )   673 - 683   2022.10( ISSN:0016-5107 )

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    BACKGROUND & AIMS: Peroral endoscopic myotomy (POEM) is conducted for patients with esophageal motility disorders based on high-resolution manometry (HRM) findings. However, the impact of POEM on HRM findings and the associations between post-POEM HRM and outcomes have not been clarified. METHODS: In a multicenter, observational cohort study, patients with achalasia treated by POEM received follow-up HRM. Associations between patient characteristics, POEM procedures, and post-POEM HRM findings, including integrated relaxation pressure (IRP) and distal contractile integral (DCI), were investigated. Furthermore, the outcomes of the POEM procedure were compared with the post-POEM HRM findings. RESULTS: Of 2,171 patients, 151 (7.0%) showed residual high post-POEM IRP (≥26 mmHg, Starlet). In a multivariate analysis, high pre-POEM IRPs (odds ratio [OR]=24.3) and gastric myotomy >2 cm (OR=0.22) were found to be positive and negative predictive factors of high post-POEM IRPs, respectively. Peristalsis recovery (DCI ≥500 mmHg-cm-sec, at least one swallow, Starlet) was visible in 121 (19.6%) of 618 patients, and they were type II-III achalasia. High pre-POEM IRP (OR=2.65) and DCI ≥500 (OR=2.98) predicted peristalsis recovery, while esophageal dilation (OR=0.42) predicted a risk of no recovery. Extended myotomy did not reveal a significant impact on peristalsis recovery. High or low post-POEM IRP and DCI did not increase the incidence of clinical failure, reflux esophagitis, or symptomatic gastroesophageal reflux disease. CONCLUSIONS: Extended gastric myotomy decreased IRP values, while peristalsis recovery depended on the characteristics of achalasia. A residual high post-POEM IRP does not necessarily mean clinical failure. Routine HRM follow-up is not recommended after POEM.

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    DOI: 10.1016/j.gie.2022.10.039

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  • Subtype of achalasia and integrated relaxation pressure measured using the starlet high-resolution manometry system: a multicenter study in Japan Reviewed

    Tatsuta T, Sato H, Fujiyoshi Y, Abe H, Shiwaku A, Shiota J, Sato C, Ominami M, Hata Y, Fukuda H, Ogawa R, Nakamura J, Ikebuchi Y, Yokomichi H, Fukuda S, Inoue H

    Journal of Neurogastroenterology and Motility   28 ( 4 )   562 - 571   2022.10( ISSN:2093-0879  eISSN:2093-0887 )

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    Background/Aims: ManoScan and Sandhill high-resolution manometry (HRM) systems are used worldwide; however, the diagnosis of achalasia on the Starlet HRM system is not fully characterized. Furthermore, the impact of calcium channel blockers and nitrites in treating achalasia has not been investigated using HRM. Management of recurrent cases is a priority issue, although few studies have examined patient characteristics. Methods: We conducted a multicenter, large-scale database analysis. First, the diagnosis of treatment-naive achalasia in each HRM system was investigated. Next, patient characteristics were compared between type I-III achalasia, and the impact of patient characteristics, including calcium channel blocker and nitrite use for integrated relaxation pressure (IRP) values, were analyzed. Finally, patient characteristics with recurrent achalasia were elucidated. Results: The frequency of type I achalasia with Starlet was significantly higher than that with ManoScan and Sandhill HRM systems. In achalasia, multivariate analysis identified male sex, advanced age, long disease duration, obesity, type I achalasia, and sigmoid type as risk factors related to normal IRP values (< 26 mmHg). Calcium channel blockers and nitrites use had no significant impact on the IRP values, although achalasia symptoms were indicated to be alleviated. In recurrent cases, the IRP value was significantly lower, and advanced age, long disease duration, and sigmoid type were more common than in treatment-naive patients. Conclusions: We should cautiously interpret the type of achalasia and IRP values in the Starlet HRM system. Symptoms of recurrent cases are related to disease progression rather than IRP values, which should be considered in decision making.

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  • Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan Reviewed

    Hironari Shiwaku; Hiroki Sato; Yuto Shimamura; Hirofumi Abe; Junya Shiota; Chiaki Sato; Masaki Ominami; Hiroyuki Sakae; Yoshitaka Hata; Hisashi Fukuda; Ryo Ogawa; Jun Nakamura; Tetsuya Tatsuta; Yuichiro Ikebuchi; Hiroshi Yokomichi; Suguru Hasegawa; Haruhiro Inoue

    ENDOSCOPY   54 ( 9 )   839 - 847   2022.10( ISSN:0013-726X )

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    DOI: 10.1055/a-1753-9801

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  • Association of egg protein levels in dust with allergy status and related factors Reviewed

    Kojima R, Miyake K, Shinohara R, Kushima M, Horiuchi S, Otawa S, Yokomichi H, Akiyama Y, Ooka T, Yamagata Z

    PEDIATRICS INTERNATIONAL   64 ( 1 )   e15372   2022.9( ISSN:1328-8067 )

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    DOI: https://doi.org/10.1111/ped.15372

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  • 生後6ヵ月までの気象条件と3歳迄のアトピー性皮膚炎発症リスク エコチル調査

    横道 洋司, 篠原 亮次, 堀内 清華, 久島 萌, 小田和 早苗, 小島 令嗣, 秋山 有佳, 大岡 忠生, 山縣 然太朗

    日本公衆衛生学会総会抄録集   81回   209 - 209   2022.9( ISSN:1347-8060 )

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  • Correction: Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan Reviewed International coauthorship

    Hironari Shiwaku, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Junya Shiota, Chiaki Sato, Masaki Ominami, Hiroyuki Sakae, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Suguru Hasegawa, Haruhiro Inoue

    Endoscopy   54 ( 09 )   C13 - C13   2022.9( ISSN:0013-726X  eISSN:1438-8812 )

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    BACKGROUND : Gastroesophageal reflux disease (GERD) and reflux esophagitis remain problems after peroral endoscopic myotomy (POEM). This study aimed to elucidate the risk factors and long-term course of reflux esophagitis and symptomatic GERD after POEM. METHODS : This multicenter cohort study involved 14 high volume centers. Overall, 2905 patients with achalasia-related esophageal motility disorders treated with POEM were analyzed for reflux esophagitis, severe reflux esophagitis (Los Angeles classification C or D), and symptomatic GERD. RESULTS : Reflux esophagitis was diagnosed in 1886 patients (64.9 %). Age ≥ 65 years (risk ratio [RR] 0.85), male sex (RR 1.11), posterior myotomy (RR 1.12), esophageal myotomy > 10 cm (RR 1.12), and gastric myotomy > 2 cm (RR 1.17) were independently associated with reflux esophagitis. Severe reflux esophagitis was diagnosed in 219 patients (7.5 %). Age ≥ 65 years (RR 1.72), previous treatments (RR 2.21), Eckardt score ≥ 7 (RR 0.68), sigmoid-type achalasia (RR 1.40), and esophageal myotomy > 10 cm (RR 1.59) were factors associated with severe reflux esophagitis. Proton pump inhibitors (PPIs) were more effective for reflux esophagitis at 5-year follow-up (P = 0.03) than after 1 year (P = 0.08). Symptomatic GERD was present in 458 patients (15.9 %). Symptom duration ≥ 10 years (RR 1.28), achalasia diagnosis (RR 0.68), integrated relaxation pressure ≥ 26 (RR 0.60), and posterior myotomy (RR 0.80) were associated with symptomatic GERD. The incidence of symptomatic GERD was lower at 5-year follow-up compared with that after 1 year (P = 0.04), particularly in PPI users (P < 0.001). CONCLUSIONS : The incidence of severe reflux esophagitis was low after POEM, but excessive myotomy for older patients with previous treatments should be avoided. Early phase symptomatic GERD is non-acid reflux dependent and the natural course is favorable, basically supporting conservative treatment.

    File: Endoscropy 2022 Shiwaku H Risk factors and longterm course of gastroesophageal reflux.pdf

    DOI: 10.1055/a-1778-9730

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  • 子どもたちのスマートフォン依存を予防するために-今、私たちができること- 1歳時のスクリーンタイムと3歳時の自閉スペクトラム症との関連 エコチル調査より

    久島 萌, 小島 令嗣, 篠原 亮次, 堀内 清華, 小田和 早苗, 大岡 忠生, 秋山 有佳, 横道 洋司, 山縣 然太朗

    日本公衆衛生学会総会抄録集   81回   144 - 144   2022.9( ISSN:1347-8060 )

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  • 世帯収入と子どもの3歳時のアレルギー疾患との関連 エコチル調査より

    小島 令嗣, 篠原 亮次, 久島 萌, 堀内 清華, 小田和 早苗, 横道 洋司, 秋山 有佳, 大岡 忠生, 山縣 然太朗

    日本公衆衛生学会総会抄録集   81回   325 - 325   2022.9( ISSN:1347-8060 )

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  • Risk scoring system for the preprocedural prediction of the clinical failure of peroral endoscopic myotomy: a multicenter case–control study Reviewed

    Hirofumi Abe, Shinwa Tanaka, Hiroki Sato, Yuto Shimamura, Hiroki Okada, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Haruhiro Inoue

    ENDOSCOPY   Online first ( 3 )   217 - 224   2022.8( ISSN:0013-726X )

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    Background and study aims Peroral endoscopic myotomy (POEM) is effective for the management of achalasia and its variants. However, this treatment can be ineffective in some patients. We aimed to develop and validate a risk scoring system for predicting the clinical failure of POEM preoperatively. Patients and methods Consecutive patients who underwent POEM in 14 high-volume centres between 2010 and 2020 were enrolled in this study. Clinical failure was defined as an Eckardt score of ≥4 or retreatment. A risk scoring system for predicting short-term clinical failure of POEM was developed using multivariable logistic regression and internally validated using bootstrapping and decision curve analysis. Results Of the 2740 study patients, 112 patients (4.1%) had clinical failure 6 months after POEM. Risk scores were assigned for three preoperative factors as follows: preoperative Eckardt score (1 point), manometric diagnosis (-4 points for type II achalasia), and a history of prior treatments (1 point for pneumatic dilation or 12 points for surgical/endoscopic myotomy). The discriminative capacity (concordance statistics, 0.68; 95% confidence interval [CI], 0.62-0.72) and calibration (slope 1.15; 95% CI, 0.87-1.40) were shown. Decision curve analysis demonstrated its clinical usefulness. Patients were categorized into low- (0-8 points: estimated risk of clinical failure <5%) and high-risk (9-22 points: ≥5%) groups. The proportions of clinical failure for the categories were stratified according to the mid-term outcomes (log-rank test; p<0.0001). Conclusions This risk scoring system can predict clinical failure of POEM preoperatively and provide useful information for making treatment decisions.

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  • Association between maternal gestational diabetes mellitus and high-sensitivity C-reactive protein levels in 8-year-old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS) Reviewed

    Tetsuo Sekine, Kyoichiro Tsuchiya, Hiroyuki Uchinuma, Sayaka Horiuchi, Megumi Kushima, Sanae Otawa, Hiroshi Yokomichi, Kunio Miyake, Yuka Akiyama, Tadao Ooka, Reiji Kojima, Ryoji Shinohara, Zentaro Yamagata, Yamanashi Adjunct Study of the Japan Environment, Children’s Study Group

    Journal of Diabetes Investigation   13 ( 8 )   1444 - 1447   2022.8( ISSN:2040-1116  eISSN:2040-1124 )

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    Gestational diabetes mellitus (GDM) is one of the most common pregnancy-related complications; it is associated with adverse pregnancy outcomes and metabolic disorders in offspring, consistent with the concept of the developmental origins of health and disease. This cohort study of women without diabetes (n = 761), who were part of the Yamanashi Adjunct Study of the Japan Environment and Children's Study, aimed to explore the associations between maternal GDM and their offspring's level of high-sensitivity C-reactive protein (hsCRP), a biomarker of inflammatory and cardiovascular diseases. We analyzed the associations between GDM and the offspring's hsCRP levels using a multiple logistic regression model. A mother with GDM significantly increased the risk for high hsCRP level by 4.07-fold (≥2.0 mg/L) in the child. As such, maternal GDM was significantly associated with increased serum hsCRP levels in 8-year-old children.

    File: J of Diabetes Invest - 2022 - Sekine - Association between maternal gestational diabetes mellitus and high‐sensitivity.pdf

    DOI: 10.1111/jdi.13796

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  • Prenatal occupational disinfectant exposure and childhood allergies: the Japan Environment and Children's Study Reviewed

    Kojima R, Shinohara R, Kushima M, Horiuchi S, Otawa S, Yokomichi H, Akiyama Y, Ooka T, Miyake K, Yamagata Z, JECS Group

    OCCUPATIONAL AND ENVIRONMENTAL MEDICINE   79   521 - 526   2022.7( ISSN:1351-0711 )

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    DOI: http://dx.doi.org/10.1136/oemed-2021-108034

    Other Link: https://oem.bmj.com/content/79/8/521

  • Geriatric patients with esophageal motility disorders benefit more from minimally invasive peroral endoscopic myotomy: a multicenter study in Japan Reviewed

    Naoto Ujiie, Hiroki Sato, Mary Raina Angeli Fujiyoshi, Shinwa Tanaka, Hironari Shiwaku, Junya Shiota, Ryo Ogawa, Hiroshi Yokomichi, Takashi Kamei, Haruhiro InoueNaoto Ujiie, Hiroki Sato, Mary Raina Angeli Fujiyoshi, Shinwa Tanaka, Hironari Shiwaku, Junya Shiota, Ryo Ogawa, Hiroshi Yokomichi, Takashi Kamei, Haruhiro Inoue

    DISEASES OF THE ESOPHAGUS   35 ( 6 )   doab086   2022.6( ISSN:1120-8694  eISSN:1442-2050 )

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    Summary

    Geriatric patients with existing studies on the safety and efficacy of peroral endoscopic myotomy (POEM) for achalasia involve small sample sizes and single institutions. However, multi-center, large-scale data analyses are lacking. The study aimed to clarify the characteristics of geriatric patients with esophageal motility disorders (EMDs) and determine the procedure-related outcomes and clinical course following POEM. This cohort study included 2,735 patients with EMDs who were treated at seven Japanese facilities between 2010 and 2019. The patients’ characteristics and post-POEM clinical courses were compared between the geriatric (age ≥ 75 years; n = 321) and non-geriatric (age &amp;lt; 75 years; n = 2,414) groups. Compared with the non-geriatric group, the geriatric group had higher American Society of Anesthesiologists physical status scores; more recurrent cases; lower incidence of chest pain; and higher incidence of type III achalasia, distal esophageal spasm, and Jackhammer esophagus. Furthermore, the incidence of sigmoid esophagus was higher, although esophageal dilation was not severe in this group. POEM was safe and effective for geriatric patients with treatment-naïve and recurrent EMDs. Furthermore, compared with the non-geriatric group, the geriatric group had lower post-POEM Eckardt scores, fewer complaints of refractory chest pain, and a lower incidence rate of post-POEM reflux esophagitis. Geriatric patients are characterized by worse clinical conditions, more spastic disorders, and greater disease progression of EMDs, which are also the indications for minimally invasive POEM. POEM is more beneficial in geriatric patients as it has lowering symptom scores and incidence rates of reflux esophagitis.

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  • Gestational age, birth weight, and perinatal complications in mothers with diabetes and impaired glucose tolerance: Japan Environment and Children’s Study cohort Reviewed Major achievement

    Hiroshi Yokomichi ,Mie Mochizuki,Ryoji Shinohara,Megumi Kushima,Sayaka Horiuchi,Reiji Kojima,Tadao Ooka,Yuka Akiyama,Kunio Miyake,Sanae Otawa,Zentaro Yamagata,on behalf of the Japan Environment and Children’s Study Group

    PLoS One   17 ( 6 )   e0269610   2022.6( ISSN:1932-6203 )

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    We aimed to determine the risk of perinatal complications during delivery in mothers with non-normal glucose tolerance in a large Japanese birth cohort. We analysed data of 24,295 neonate-mother pairs in the Japan Environment and Children's Study cohort between 2011 and 2014. We included 67 mothers with type 1 diabetes, 102 with type 2 diabetes (determined by questionnaire), 2,045 with gestational diabetes (determined by diagnosis), and 2,949 with plasma glucose levels ≥140 mg/dL (shown by a screening test for gestational diabetes). Gestational age, birth weight, placental weight, and proportions of preterm birth, and labour and neonatal complications at delivery in mothers with diabetes were compared with those in mothers with normal glucose tolerance. Mean gestational age was shorter in mothers with any type of diabetes than in mothers without diabetes. Birth weight tended to be heavier in mothers with type 1 diabetes, and placental weight was significantly heavier in mothers with type 1 and gestational diabetes and elevated plasma glucose levels (all p<0.05). The relative risks of any labour complication and any neonatal complication were 1.49 and 2.28 in type 2 diabetes, 1.59 and 1.95 in gestational diabetes, and 1.22 and 1.30 in a positive screening test result (all p<0.05). The relative risks of preterm birth, gestational hypertension, and neonatal jaundice were significantly higher in mothers with types 1 (2.77; 4.07; 2.04) and 2 diabetes (2.65; 5.84; 1.99) and a positive screening test result (1.29; 1.63; 1.12) than in those without diabetes (all p<0.05). In conclusion, placental weight is heavier in mothers with non-normal glucose tolerance. Preterm birth, gestational hypertension, and jaundice are more frequent in mothers with types 1 and 2 diabetes. A positive result in a screening test for gestational diabetes suggests not only a non-normal glucose tolerance, but also a medium (middle-level) risk of perinatal complications.

    File: PLoS One 2022 Yokomichi H Maternal diabetes and perinatal complications.pdf

    DOI: 10.1371/journal.pone.0269610

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  • Esophageal carcinoma in achalasia patients managed with endoscopic submucosal dissection and peroral endoscopic myotomy: Japan Achalasia Multicenter Study Reviewed

    Sato H, Nishikawa Y, Abe H, Shiwaku H, Shiota J, Sato C, Sakae H, Ominami M, Hata Y, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Terai S, Inoue H Shiota J, Sato C, Sakae H, Hata Y, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Fujiwara Y, Inoue H

    Digestive Endoscopy   34 ( 5 )   965 - 973   2022.6( ISSN:0915-5635  eISSN:1443-1661 )

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    OBJECTIVES: Indications for peroral endoscopic myotomy (POEM) and endoscopic submucosal dissection (ESD) in patients with achalasia concomitant with esophageal carcinoma (EC) are unclear. This study aimed to clarify the role of POEM in cases of achalasia concomitant with EC and to elucidate the indications for ESD and efficient surveillance for EC. METHODS: We conducted a multicenter cohort study at 14 hospitals in Japan, including 3707 cases of achalasia-related esophageal motility disorders (EMDs). Factors contributing to EC risk, the characteristics of EC, and clinical outcomes of POEM/ESD were analyzed. RESULTS: In patients undergoing POEM, screening and surveillance endoscopy throughout a 1-year period resulted in diagnosis of 72.1% new EC cases. Of 62 patients with 123 ECs, 40.3% had multiple or metachronous lesions within 37.5 months. EC was predominantly observed in the middle thoracic esophagus (58.5%) and posteriorly (73.2%). POEM had comparable safety and efficacy in cases of concomitant EC even after ESD. Endoscopic en bloc resection was performed in 95.8% and 89.3% of ECs diagnosed before and after POEM, respectively (P = 0.351); however, ESD on the POEM-line was impaired by fibrosis. Multivariate analysis revealed risk factors for EC, including regular alcohol consumption, a history of smoking, advanced age, and extended disease duration. Alcohol intake and smoking had a synergistic effect on EC development. CONCLUSIONS: Screening and surveillance of POEM help in detecting EC. ESD is feasible in achalasia, although on the POEM-line is challenging. Surveillance endoscopy for EC is recommended for cases with specific risks and a history of ECs.

    File: Digestive Endoscopy 2021 Sato H Esophageal carcinoma in achalasia patients managed with endoscopic submucosal.pdf

    DOI: 10.1111/den.14197

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  • Efficacy of peroral endoscopic myotomy for esophageal motility disorders after gastric surgery: Japan Achalasia Multicenter Study Reviewed

    Nakamura J, Sato H, Onimaru M, Abe H, Shiwaku H, Shiota J, Sato C, Sakae H, Ominami M, Hata Y, Fukuda H, Ogawa R, Tatsuta T, Ikebuchi Y, Yokomichi H, Hikichi T, Inoue H

    Digestive Endoscopy   34 ( 7 )   1394 - 1402   2022.6( ISSN:0915-5635 )

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    OBJECTIVES: Patients with esophageal motility disorders (EMDs) including achalasia after gastric surgery have not been thoroughly characterized. Furthermore, the efficacy of peroral endoscopic myotomy (POEM) in this population should be clarified. METHODS: In this retrospective multicenter study of 3,707 patients with EMDs, 31 patients (0.8%) had a history of gastric surgery. Patient characteristics and POEM efficacy were compared between patients with and without previous gastric surgery. RESULTS: In patients with EMD after gastric surgery, age at EMD diagnosis was higher (72.0 years), male sex was predominant (90.3%), and the American Society of Anesthesiologists physical status score was higher (≥II, 48.4%). High-resolution manometry (HRM) findings did not reveal significant differences. In patients who underwent gastric surgery, atrophic gastritis was common (80.6%), and gastric cancer was the primary surgical indication (32.3%). Distal gastrectomy was performed in 28 patients (90.3%). POEM was effective (3.3% adverse events; 100% treatment success). The incidence rates of reflux esophagitis (RE) and symptomatic gastroesophageal reflux disease (GERD) were 60.0% and 16.7%, respectively, without significant inter-group differences, and severe RE was not observed in the long-term follow-up. Extended gastric myotomy was a risk factor for RE. CONCLUSIONS: Patients with gastric surgery often present severe disease manifestations; the surgical indication is mainly gastric cancer. HRM findings can be similarly used for diagnosis in patients with and without gastric surgery. POEM maintains safety and efficacy with acceptable RE and symptomatic GERD rates. To prevent RE, extended myotomy should be avoided.

    DOI: 10.1111/den.14369

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  • Correction: Gestational body weight gain and risk of low birth weight or macrosomia in women of Japan: a nationwide cohort study.

    Hiroyuki Uchinuma, Kyoichiro Tsuchiya, Tetsuo Sekine, Sayaka Horiuchi, Megumi Kushima, Sanae Otawa, Hiroshi Yokomichi, Kunio Miyake, Yuka Akiyama, Tadao Ooka, Reiji Kojima, Ryoji Shinohara, Shuji Hirata, Zentaro Yamagata

    International journal of obesity (2005)   46 ( 6 )   1251 - 1251   2022.6

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  • Prenatal Negative Life Events and Childhood Allergies: The Japan Environment and Children’s Study (JECS) Reviewed

    Reiji Kojima, Ryoji Shinohara, Megumi Kushima, Sayaka Horiuchi, Sanae Otawa, Hiroshi Yokomichi, Yuka Akiyama, Tadao Ooka, Kunio Miyake, Zentaro Yamagata

    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY   19 ( 10 )   1 - 9   2022.5( ISSN:1018-2438  eISSN:1423-0097 )

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    &lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; It is inconclusive whether prenatal negative life events are a risk for the development of allergic diseases in children or whether social capital modifies the association. The objective of this study was to examine whether women’s experiences of such events during pregnancy were associated with the development of allergic diseases in their offspring at 3 years old and whether social capital moderated this association. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We used data from 81,337 mother-child pairs who participated in the Japan Environment and Children’s Study. This is a prospective birth cohort recruited between January 2011 and March 2014. We examined the associations between prenatal maternal negative life events (e.g., bereavement, financial, and marital problems) during pregnancy and allergic diseases (asthma, eczema, and food allergies) in children after adjustment for covariates using multivariate logistic regression. We also examined interactions between these life events and social capital, measured as two items, social cohesion and social support. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Prenatal negative life events were significantly associated with doctor-diagnosed asthma at 3 years old with a dose-response relationship (one life event vs. none: adjusted odds ratio 1.13, 95% confidence interval [CI]: 1.07–1.20; two life events vs. none: adjusted odds ratio 1.24, 95% CI: 1.13–1.36; three or more life events vs. none: adjusted odds ratio 1.26, 95% CI: 1.10–1.46; &lt;i&gt;p&lt;/i&gt; for trend &amp;#x3c;0.01). Similar results were observed for eczema and food allergies. There were no interactions between life events and social capital. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Prenatal negative life events may be a risk factor for allergies in children. There was no modification of the effect of these events by social capital.

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  • Risks of refractory chest pain after peroral endoscopic myotomy in achalasia-related esophageal motility disorders: short-term results from a multicenter study in Japan Reviewed

    Hisashi Fukuda, Hiroki Sato, Yusuke Fujiyoshi, Hirofumi Abe, Hiroki Okada, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Hironori Yamamoto, Haruhiro Inoue

    GASTROINTESTINAL ENDOSCOPY   96 ( 4 )   620 - 629   2022.5( ISSN:0016-5107 )

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    DOI: 10.1016/j.gie.2022.04.1347

    Other Link: https://www.sciencedirect.com/science/article/pii/S0016510722016662

  • Association of the incidence of atopic dermatitis until 3 years old with climate conditions in the first 6 months of life: Japan Environment and Children’s Study (JECS) Reviewed Major achievement

    Hiroshi Yokomichi ,Mie Mochizuki,Ryoji Shinohara,Megumi Kushima,Sayaka Horiuchi,Reiji Kojima,Tadao Ooka,Yuka Akiyama,Kunio Miyake,Sanae Otawa,Zentaro Yamagata,on behalf of the Japan Environment and Children’s Study Group

    PLoS One   17 ( 5 )   e0268204   2022.5( ISSN:1932-6203 )

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    DOI: 10.1371/journal.pone

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  • Impact of the COVID-19 pandemic on high-resolution manometry and peroral endoscopic myotomy for esophageal motility disorder in Japan Reviewed

    Ominami M, Sato H, Fujiyoshi Y, Abe H, Shiwaku H, Shiota J, Sato C, Sakae H, Hata Y, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Fujiwara Y, Inoue H

    Digestive Endoscopy   34 ( 4 )   769 - 777   2022.5( ISSN:0915-5635  eISSN:1443-1661 )

  • Development of dilated esophagus, sigmoid esophagus, and esophageal diverticulum in patients with achalasia: Japan Achalasia Multicenter study Reviewed

    Sato H, Fujiyoshi Y, Abe H, Shiwaku H, Shiota J, Sato C, Sakae H, Ominami M, Hata Y, Fukuda H, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Terai S, Inoue H

    Journal of Neurogastroenterology and Motility   28 ( 2 )   222 - 230   2022.4( ISSN:2093-0879  eISSN:2093-0887 )

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    BACKGROUND/AIMS: Patients with achalasia-related esophageal motility disorders (AEMDs) frequently present with dilated and sigmoid esophagus, and develop esophageal diverticulum (ED), although the prevalence and patients characteristics require further elucidation. METHODS: We conducted a multicenter cohort study of 3707 patients with AEMDs from 14 facilities in Japan. Esophagography on 3682 patients were analyzed. RESULTS: Straight (n = 2798), sigmoid (n = 684), and advanced sigmoid esophagus (n = 200) were diagnosed. Multivariate analysis revealed that long disease duration, advanced age, obesity, and type I achalasia correlate positively, whereas severe symptoms and integrated relaxation pressure correlate negatively with development of sigmoid esophagus. In contrast, Grade II dilation (3.5-6.0 cm) was the most common (52.9%), while grade III dilation (≥ 6 cm) was rare (5.0%). We found early onset, male, obesity, and type I achalasia correlated positively, while advanced age correlated negatively with esophageal dilation. Dilated and sigmoid esophagus were found mostly in types I and II achalasia, but typically not found in spastic disorders. The prevalence of ED was low (n = 63, 1.7%), and non-dilated esophagus and advanced age correlated with ED development. Patients with right-sided ED (n = 35) had a long disease duration (P = 0.005) with low integrated relaxation pressure values (P = 0.008) compared with patients with left-sided ED (n = 22). Patients with multiple EDs (n = 6) had lower symptom severity than patients with a single ED (P = 0.022). CONCLUSIONS: The etiologies of dilated esophagus, sigmoid esophagus, and ED are considered multifactorial and different. Early diagnosis and optimal treatment of AEMDs are necessary to prevent these conditions.

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  • Association of glycated hemoglobin at an early stage of pregnancy with the risk of gestational diabetes mellitus among non-diabetic women in Japan: The Japan Environment and Children’s Study Reviewed

    Tetsuo Sekine, Kyoichiro Tsuchiya, Hiroyuki Uchinuma, Sayaka Horiuchi, Megumi Kushima, Sanae Otawa, Hiroshi Yokomichi, Kunio Miyake, Yuka Akiyama, Tadao Ooka, Reiji Kojima, Ryoji Shinohara, Shuji Hirata, Zentaro Yamagata, Japan Environment and Children’s Study GroupTetsuo Sekine, Kyoichiro Tsuchiya, Hiroyuki Uchinuma, Sayaka Horiuchi, Megumi Kushima, Sanae Otawa, Hiroshi Yokomichi, Kunio Miyake, Yuka Akiyama, Tadao Ooka, Reiji Kojima, Ryoji Shinohara, Shuji Hirata, Zentaro Yamagata, Japan Environment and Children’s Study Group

    Journal of Diabetes Investigation   13 ( 4 )   687 - 695   2022.4( ISSN:2040-1116  eISSN:2040-1124 )

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    Aims/Introduction Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and is associated with adverse pregnancy outcomes. This study aimed to explore the associations between glycated hemoglobin (HbA1c) levels at the early stage of pregnancy and the GDM risk among non-diabetic women in a nationwide study in Japan. In addition, the relationship between GDM and adverse pregnancy outcomes was also analyzed. Materials and Methods This cohort study (n = 89,799) used data from the Japan Environment and Children's Study. We stratified the participants into four groups according to HbA1c levels at an early stage of pregnancy. We investigated the association of HbA1c at an early stage of pregnancy with the risk of GDM, and of GDM with the risk of some representative adverse pregnancy outcomes, using the multiple logistic regression model with adjustment for potential confounders. Results The adjusted odds ratio for GDM per 0.1 percentage point increase in HbA1c (%) was 1.20. The adjusted odds ratio for developing GDM was significantly increased in women from the HbA1c 5.0-5.4% category. GDM significantly increased the adjusted odds ratio for adverse pregnancy outcomes, such as hypertensive disorders of pregnancy, polyhydramnios and premature birth. Conclusions High-normal HbA1c levels at the early stage of pregnancy are significantly associated with GDM risk in women in Japan. GDM was significantly associated with adverse pregnancy outcomes.

    DOI: 10.1111/jdi.13701

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  • Association between screen time exposure in children at 1 year of age and autism spectrum disorder at 3 years of age Reviewed

    Megumi Kushima; Reiji Kojima; Ryoji Shinohara; Sayaka Horiuchi; Sanae Otawa; Tadao Ooka; Yuka Akiyama; Kunio Miyake; Hiroshi Yokomichi; Zentaro Yamagata ; Japan Environment and Children’s Study Group

    JAMA Pediatrics   176 ( 4 )   384 - 391   2022.4( ISSN:2168-6203 )

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    IMPORTANCE: It is unclear to what extent the duration of screen time in infancy is associated with the subsequent diagnosis of autism spectrum disorder. OBJECTIVE: To examine the association between screen time in infancy and the development of autism spectrum disorder at 3 years of age. DESIGN, SETTING, AND PARTICIPANTS: This cohort study analyzed data from mother-child dyads in a large birth cohort in Japan. This study included children born to women recruited between January 2011 and March 2014, and data were analyzed in December 2020. The study was conducted by the Japan Environment and Children's Study Group in collaboration with 15 regional centers across Japan. EXPOSURES: Screen time at 1 year of age. MAIN OUTCOMES AND MEASURES: The outcome variable, children diagnosed with autism spectrum disorder at 3 years of age, was assessed using a questionnaire administered to mothers of the participating children. RESULTS: A total of 84 030 mother-child dyads were analyzed. The prevalence of children with autism spectrum disorder at 3 years of age was 392 per 100 000 (0.4%), and boys were 3 times more likely to have been diagnosed with autism spectrum disorder than were girls. Logistic regression analysis showed that among boys, when "no screen" was the reference, the adjusted odds ratios were as follows: less than 1 hour, odds ratio, 1.38 (95 % CI, 0.71-2.69; P = .35), 1 hour to less than 2 hours, odds ratio, 2.16 (95 % CI, 1.13-4.14; P = .02), 2 hours to less than 4 hours, odds ratio, 3.48 (95% CI, 1.83-6.65; P < .001), and more than 4 hours, odds ratio, 3.02 (95% CI, 1.44-6.34; P = .04). Among girls, however, there was no association between autism spectrum disorder and screen time. CONCLUSIONS AND RELEVANCE: Among boys, longer screen time at 1 year of age was significantly associated with autism spectrum disorder at 3 years of age. With the rapid increase in device usage, it is necessary to review the health effects of screen time on infants and to control excessive screen time.

    File: JAMA Pediatr 2022 Kushima M Screen time and autism.pdf

    DOI: 10.1001/jamapediatrics.2021.5778

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  • Automatic discrimination of Yamamoto-Kohama classification by machine learning approach for invasive pattern of oral squamous cell carcinoma using digital microscopic images: A retrospective study Reviewed

    Kunio Yoshizawa, Hidetoshi Ando, Yujiro Kimura, Shuichi Kawashiri, Hiroshi Yokomichi, Akinori Moroi, Koichiro Ueki

    Oral Surgery Oral Medicine Oral Pathology Oral Radiology   133 ( 4 )   441 - 452   2022.4( ISSN:2212-4403 )

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    File: PIIS2212440321006830.pdf

    DOI: 10.1016/j.oooo.2021.10.004

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  • Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study Reviewed

    Tsubasa Matsuoka, Koji Hosomi, Jonguk Park, Yuka Goto, Mao Nishimura, Satoko Nakashima, Haruka Murakami, Kana Konishi, Motohiko Miyachi, Hitoshi Kawashima, Kenji Mizuguchi, Toshiki Kobayashi, Hiroshi Yokomichi, Jun Kunisawa, Zentaro Yamagata

    BMC Nutrition   8 ( 1 )   23   2022.3( ISSN:2055-0928  eISSN:2055-0928 )

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    Abstract

    Background

    Barley contains abundant soluble beta-glucan fibers, which have established health benefits. In addition, the health benefits conferred by the gut bacteria have attracted considerable interest. However, few studies have focused on the barley consumption and gut bacteria of the Japanese population. In this study, we aimed to identify the relationship between the barley consumption and gut bacteria composition of the Japanese population.

    Methods

    In total, 236 participants were recruited in Japan, and 94 participants with no complications of diabetes, hypertension, or dyslipidemia were selected for the study. We analyzed fecal samples from the participants, their medical check-up results, and responses to questionnaires about dietary habits. The participants were grouped according to their median barley consumption. Then, we assessed the relative abundance of 50 genera. Characteristic bacteria were evaluated for their relationship with barley consumption by multiple regression analysis, adjusted for disease and dietary habits, in all participants. We also analyzed the networks and clustering of the 20 selected genera.

    Results

    According to the comparison between barley groups, Bifidobacterium, Butyricicoccus, Collinsella, Ruminococcus 2, and Dialister were characteristic candidate bacterias of the group that consumed large amounts of barley (P &lt; 0.05). The relationship between barley consumption and Bifidobacterium remained after adjusting for disease and dietary habits, and that of Butyricicoccus remained after adjusting for disease. Furthermore, network and cluster analyses revealed that barley consumption was directly correlated with Bifidobacterium and Butyricicoccus.

    Conclusions

    Barley consumption generates changes in the intestinal bacteria of the Japanese population. We found that Bifidobacterium and Butyricicoccus abundance was positively associated with barley consumption.

    File: s40795-022-00500-3.pdf

    DOI: 10.1186/s40795-022-00500-3

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  • Per‐oral endoscopic myotomy in patients with antithrombotic agents: a large‐scale multicenter study in Japan Reviewed

    Yuto Shimamura, Hiroki Sato, Manabu Onimaru, Shinwa Tanaka, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Ryo Ogawa, Hiroshi Yokomichi, Haruhiro Inoue

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   37 ( 3 )   480 - 488   2022.3( ISSN:0815-9319  eISSN:1440-1746 )

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    DOI: 10.1111/jgh.15708

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  • Relationship between diarrhoea risk and the combinations of drinking water sources in the Kathmandu Valley, Nepal Reviewed

    Kobayashi Y;Yuri Ito Y;Shrestha S;Yokomichi H;Nishida K

    International Health   14 ( 2 )   195 - 200   2022.3( ISSN:1876-3413  eISSN:1876-3405 )

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    Abstract

    In Nepal, the number of diarrhoea hospitalizations in all ages is seriously high. According to the World Health Organization, diarrheal diseases can be substantially prevented through safe drinking water sources. In the Kathmandu Valley, because of the shortage of piped water, local residents use alternative water sources, such as groundwater, jars and tanker water. However, these alternative water sources can be contaminated. This study aimed to clarify the relationship between diarrhoea risk and the combinations of drinking water sources. A survey using multiple questionnaires on diarrhoea occurrence, water sources and water treatment was conducted three time between 2015 and 2016. The odds ratios (ORs) of developing diarrhoea were significantly high for drinking jar (OR 6.1) and tanker water (OR 8.4) compared with not drinking. The combined drinking of jar and tanker water obtained the 1 log higher OR compared with drinking only piped water. Conversely, drinking groundwater had a low OR, implying that the residents refrained from drinking polluted groundwater. In conclusion, diarrhoea occurrence was related not only to the level of water contamination, but also to a behavioural factor, i.e. people's careful management of the choice of multiple water sources.

    File: Int Health Koyayashi Y Drinking water source and diarrhoea.pdf

    DOI: 10.1093/inthealth/ihab032

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  • エコチル調査における妊娠時期に応じた妊婦の体重増加量と低出生体重児・巨大児リスクの検討

    内沼 裕幸, 土屋 恭一郎, 関根 哲生, 堀内 清華, 久島 萌, 小田和 早苗, 横道 洋司, 三宅 邦夫, 秋山 有佳, 大岡 忠生, 小島 令嗣, 篠原 亮次, 平田 修司, 山縣 然太朗

    肥満研究   27 ( Suppl. )   332 - 332   2022.3( ISSN:1343-229X )

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  • High incidence of atopic dermatitis among children whose fathers work in primary industry: The Japan Environment and Children’s Study (JECS) Reviewed Major achievement

    Yokomichi H, Mochizuki M, Kojima R, Horiuchi S, Ooka T, Akiyama Y, Miyake K, Kushima M, Otawa S, Shinohara R, Yamagata Z

    International Journal of Environmental Research and Public Health   19 ( 3 )   1761   2022.2( ISSN:1660-4601 )

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    The hygiene hypothesis assumes a low incidence of allergic diseases in families engaging in farming work. However, a few studies have indicated rural life as a potential risk factor for atopic dermatitis (AD). Using a large Japanese birth cohort dataset, we calculated the accumulated incidence of AD in children aged 6 months and 1, 2, and 3 years by family business and the hazard ratio. We adjusted for confounding factors. The father's job was considered the family business. We analysed data on 41,469 father-child pairs at 6 months of age, 40,067 pairs at 1 year, 38,286 pairs at 2 years, and 36,570 pairs at 3 years. We found the highest accumulated incidence of AD among children with fathers engaged in primary industry, with 2.5% at the age of 6 months, 6.6% at 1 year, 12.0% at 2 years, and 15.4% at 3 years. Among primary industry occupations, forestry was associated with the highest incidence of AD across these ages. The hazard ratio of AD was also highest for children whose family business was primary industry. In conclusion, the highest incidence and hazard ratio of AD were observed among children whose fathers worked in primary industry.

    File: IJREPH 2022 Yokomichi H et al. Farming household and incidence of atopic dermatitis.pdf

    DOI: 10.3390/ijerph19031761

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  • Adiposity rebound may be a predictive index of body size for adolescents—Based on retrospective cohort data in a Japanese rural area Reviewed

    Haga C, Yokomichi H, KyokoTsuji K, Yamagata Z

    Obesity Research & Clinical Practice   16 ( 1 )   50 - 55   2022.1( ISSN:1871-403X )

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    BACKGROUND: We aimed to examine whether the timing of adiposity rebound (AR) could be a predictive index of body size in Japanese adolescents. METHODS: The longitudinal individual data of 1438 Japanese children, including 714 boys and 724 girls born between 2001 and 2007, were obtained from child health check-ups conducted at ages 1.5, 2, 3, and 5 years, and then yearly after the age of 6 years. We examined whether the timing of AR could be used to estimate the body size at 14 years of age. RESULTS: The AR had a normal distribution with a mean occurrence at age 6-7 years. The odds ratio of having obesity at age 14 were 8.32 for boys and 4.81 for girls, whereas boys and girls with later AR at the same age had a relative risk of thinness of 6.27 and 8.14, respectively. The probability that children with an early AR (i.e., <6 years old) would be obese was nearly 40%. Similar to obesity, the probability of thinness at 14 years remained approximately 8% for both sexes. CONCLUSIONS: The findings suggest that early AR could raise the risk of obesity, and AR could later raise the risk of thinness. However, both probabilities of AR timing as predictors of adolescent weight status may only be about 10%-20%. This study cannot clearly determine whether the results were influenced by other factors after controlling for the timing of AR. Future studies that also consider lifestyle and genetic factors are warranted.

    File: Obes Res Clin Pract 2021 Haga C Adiposity rebound as predictor of adolescent obesity.pdf

    DOI: 10.1016/j.orcp.2021.12.003

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  • Mother’s iodine exposure and infants’ hypothyroidism: The Japan Environment and Children’s Study Reviewed Major achievement

    Yokomichi H, Mochizuki M, Kojima R, Horiuchi S, Ooka T, Akiyama Y, Miyake K, Kushima M, Otawa S, Shinohara R, Yamagata Z, Japan Environment and Children’s Study Group

    ENDOCRINE JOURNAL   69 ( 1 )   9 - 21   2022.1( ISSN:0918-8959 )

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    In this study, we aimed to determine the association of neonatal/post-neonatal hypothyroidism with mother's iodine exposure, especially povidone iodine disinfection, and hysterosalpingography. Participants were mother-child pairs in a Japanese birth cohort (n = 100,286). Risk factors of hypothyroidism were supplement intake, seaweed intake, other daily iodine intake, povidone iodine disinfection at delivery, and maternal history of hysterosalpingography, thyroid disease (Graves' disease and Hashimoto's thyroiditis), and medication (thiamazole and levothyroxine). Congenital hypothyroidism (CH) at age 1 year was assessed using a questionnaire. Transient hypothyroidism was defined as elevated thyroid stimulating hormone level at birth and absence of CH at age 1 year. The incidence of CH at age 1 year per 100 children was 1.1 for those born at 22-30 weeks' gestation, 0.17 following povidone iodine disinfection, and 0.07, 0.95, 0.81, 1.17, and 1.15 with a maternal history of hysterosalpingography, Graves' disease, Hashimoto's thyroiditis, thiamazole use, and levothyroxine use, respectively. Odds ratios (95% confidence intervals) of CH at age 1 year for povidone iodine disinfection, hysterosalpingography history, maternal Graves' disease, and maternal Hashimoto's thyroiditis were 1.13 (0.71-1.79), 0.47 (0.07-3.36), 7.06 (3.70-13.5), and 5.93 (2.90-12.1), respectively. For transient hypothyroidism for povidone iodine disinfection and hysterosalpingography history, these values were 1.99 (1.51-2.62) and 0.63 (0.20-1.96), respectively. Maternal thyroid disease greatly increased neonatal/post-neonatal hypothyroidism risk. Povidone iodine disinfection may increase transient hypothyroidism risk but not the risk at 1 year of age. Hysterosalpingography does not increase hypothyroidism risk from birth to age 1 year.

    File: Endcr J 2022 Yokomichi H et al. Mother's iodine exposure and neonate's hypothyroidism.pdf

    DOI: 10.1507/endocrj.EJ21-0168

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  • Association between Household Income and Allergy Development in Children: The Japan Environment and Children’s Study Reviewed

    Reiji Kojima, Ryoji Shinohara, Megumi Kushima, Sayaka Horiuchi, Sanae Otawa, Hiroshi Yokomichi, Yuka Akiyama, Tadao Ooka, Kunio Miyake, Zentaro Yamagata

    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY   183 ( 2 )   201 - 209   2022.1( ISSN:1018-2438  eISSN:1423-0097 )

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    &lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Socioeconomic status has been found to be associated with allergic diseases in children, but results are inconsistent. This study aimed to assess the association between household income and the development of allergic disease in children at 3 years old. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We used data from 72,180 participants from the Japan Environment and Children’s Study, which is a prospective birth cohort study with participants recruited from January 2011 to March 2014. We examined the associations between household income and allergic diseases (asthma, eczema, and food allergies) in children, adjusting for covariates using multivariate logistic regression. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; The percentages of doctor-diagnosed allergies at 3 years old were 7.5% for asthma, 7.2% for eczema, and 6.2% for food allergies. Children from households with an annual income of &amp;#x3c;2 million yen (approx. 18,000 USD) had a significantly higher risk of doctor-diagnosed asthma and eczema than those from households with an income of 4–6 million yen. The adjusted odds ratios (aORs) were 1.17 (95% confidence interval [CI] 1.03–1.34) and 1.21 (95% CI 1.06–1.39). Children from households with an income of &amp;#x3e;6 million yen tended to have an increased risk of food allergies (aOR 1.07, 95% CI 0.98–1.15). &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Low household income was a risk for doctor-diagnosed asthma and eczema, suggesting that public health professionals should recognize low-income groups as vulnerable populations for these conditions.

    DOI: 10.1159/000519153

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  • Characteristics of patients with esophageal motility disorders on high-resolution manometry and esophagography - a large database analysis in Japan Reviewed

    Sato C, Sato H, Kamei T, Shimamura Y, Tanaka S, Shiwaku H, Shiota J, Ogawa R, Yokomichi H, Inoue H

    Esophagus   19   182 - 188   2022.1( ISSN:1612-9059 )

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    DOI: https://doi.org/10.1007/s10388-021-00875-5

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  • Characteristics of patients with esophageal motility disorders on high-resolution manometry and esophagography—a large database analysis in Japan Reviewed

    Chiaki Sato, Hiroki Sato, Takashi Kamei, Yuto Shimamura, Shinwa Tanaka, Hironari Shiwaku, Junya Shiota, Ryo Ogawa, Hiroshi Yokomichi, Haruhiro Inoue

    Esophagus   19 ( 1 )   182 - 188   2022.1( ISSN:1612-9059  eISSN:1612-9067 )

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    File: Esophagus 2022 Sato C Characteristics of patients with esophageal motility disorders.pdf

    DOI: 10.1007/s10388-021-00875-5

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  • Factors of parental COVID-19 vaccine hesitancy: A cross sectional study in Japan Reviewed

    Sayaka Horiuchi , Haruka Sakamoto, Sarah K. Abe, Ryoji Shinohara, Megumi Kushima, Sanae Otawa, Hideki Yui, Yuka Akiyama, Tadao Ooka, Reiji Kojima, Hiroshi Yokomichi, Kunio Miyake, Takashi Mizutani, Zentaro Yamagata

    PLoS One   16 ( 12 )   e0261121 - e0261121   2021.12( ISSN:1932-6203  eISSN:1932-6203 )

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    The eligibility of COVID-19 vaccines has been expanded to children aged 12 and above in several countries including Japan, and there is a plan to further lower the age. This study aimed to assess factors related to parental COVID-19 vaccine hesitancy. A nationwide internet-based cross-sectional study was conducted between May 25 and June 3, 2021 in Japan. The target population was parents of children aged 3–14 years who resided in Japan, and agreed to answer the online questionnaire. Parental COVID-19 vaccine hesitancy (their intention to vaccinate their child) and related factors were analyzed using logistic regression models. Interaction effects of gender of parents and their level of social relationship satisfaction related to parental vaccine hesitancy was tested using log likelihood ratio test (LRT). Social media as the most trusted information source increased parental vaccine hesitancy compared to those who trusted official information (Adjusted Odds Ratio: aOR 2.80, 95% CI 1.53–5.12). Being a mother and low perceived risk of infection also increased parental vaccine hesitancy compared to father (aOR 2.43, 95% CI 1.57–3.74) and those with higher perceived risk of infection (aOR 1.55, 95% CI 1.04–2.32) respectively. People with lower satisfaction to social relationships tended to be more hesitant to vaccinate their child among mothers in contrast to fathers who showed constant intention to vaccinate their child regardless of the level of satisfaction to social relationship (LRT p = 0.021). Our findings suggest that dissemination of targeted information about COVID-19 vaccine by considering means of communication, gender and people who are isolated during measures of social distancing may help to increase parental vaccine acceptance.

    File: PLoS One 2021 Horiuchi S COVID-19 vaccine hesitancy in Japan.pdf

    DOI: 10.1371/journal.pone.0261121

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  • Influence of Maternal Active and Secondhand Smoking during Pregnancy on Childhood Obesity at 3 Years of Age: A Nested Case–Control Study from the Japan Environment and Children’s Study (JECS) Reviewed

    Sayaka Horiuchi;Ryoji Shinohara;Sanae Otawa;Megumi Kushima;Yuka Akiyama;Tadao Ooka;Reiji Kojima;Hiroshi Yokomichi;Kunio Miyake;Hiroyuki Hirai;Koichi Hashimoto;Michio Shimabukuro;Zentaro Yamagata;Japan Environment;Children’s Study Group

    International Journal of Environmental Research and Public Health   18 ( 23 )   12506   2021.11( ISSN:1660-4601 )

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    Maternal smoking during pregnancy is a risk factor for childhood obesity; however, the combined effect of secondhand smoking during pregnancy on children in the early years is unclear. We examined the effects of maternal active and secondhand smoking during pregnancy on childhood obesity in a large population-based cohort. A nested case-control study originating from the Japan Environment and Children's Study was performed. The maternal smoking status was collected via self-administered questionnaires during mid/late pregnancy. Obesity in children was determined based on BMI measured at 3 years of age. In total, 4875 cases and 19,491 controls were included in the analyses. Conditional logistic regression models with a significance level of 5% (two-tailed test) were used to test the association. The proportion of mothers who continued smoking and who were exposed to secondhand smoking daily during pregnancy were 3.9% and 13.0% in cases and 2.9% and 10.8% in controls, respectively. Continuous maternal smoking was associated with increased odds of obesity compared to those who never smoked or quit smoking before the pregnancy (adjusted odds ratio, 1.39; 95% confidence interval, 1.01-1.92). The odds increased further when combined with secondhand smoking. The promotion of non-smoking among family members, in public and workplace could benefit pregnant women and offspring.

    File: ijerph-18-12506-v2.pdf

    DOI: 10.3390/ijerph182312506

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  • Association between maternal exposure to chemicals during pregnancy and the risk of foetal death: the Japan Environment and Children’s Study Reviewed

    Tadao Ooka, Sayaka Horiuchi, Ryoji Shinohara, Reiji Kojima, Yuka Akiyama, Kunio Miyake, Sanae Otawa, Hiroshi Yokomichi, Zentaro Yamagata

    International Journal of Environmental Research and Public Health   18 ( 11748 )   2021.11( ISSN:1660-4601 )

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    Scarce knowledge is available on the relationship between maternal chemical exposure during pregnancy and foetal deaths. We studied the association of spontaneous abortions and stillbirths with occupational or daily maternal exposure to chemicals commonly used by pregnant women. Data from the Japan Environment and Children's Study (JECS), a nationwide prospective birth cohort study, were used. The participants of the study were asked about the frequency of their use of gasoline, pesticides, hair dye, and chlorine bleach during the first and the second to third trimesters of pregnancy. We investigated the relationship between the frequency of the use of chemicals and foetal death. Of the 104,065 foetuses, 923 (0.91%) were spontaneous abortions and 379 (0.37%) were stillbirths. Any type of exposure during the first trimester was not significantly associated with spontaneous abortions. Nevertheless, a more than weekly occupational use of hair dye from the first to the second/third trimester was significantly associated with stillbirth. The results of this study suggest that the frequent use of hair dye during pregnancy can have severe adverse effects on the foetus. These findings can help pregnant women, especially hairdressers, refrain from the continuous use of hair dyes.

    File: ijerph 2021 Ooka T Chemicals during pregnancy and foetal death.pdf

    DOI: 10.3390/ijerph182211748

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  • Elective caesarean delivery at term and its effects on respiratory distress at birth in Japan: The Japan Environment and Children's Study Reviewed

    Horiuchi S;Shinohara R;Otawa S;Kushima M;Akiyama Y;Ooka T;Kojima R;Yokomichi H;Miyake K;Yamagata Z;The Japan Environment;Children's Study Group

    Health Science Reports   4 ( 4 )   e421   2021.10( ISSN:2398-8835 )

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    BACKGROUND AND AIMS: Early-term birth between 37 and 38 weeks of gestation increases the risk of mortality and morbidity. This study investigated the status and impact of early-term birth among neonates born by cesarean section in Japan. METHODS: All singleton live births that had data of gestational age at birth available in the Japan Environment and Children's Study (JECS), a nationwide birth cohort study launched in 2011, were eligible for this study. Neonates born by cesarean delivery at term without indications for early delivery were included to examine the association between early-term birth and respiratory distress at birth. The gestational age at birth was categorized as 37 weeks 0 day to 38 weeks 6 days (early-term), 39 weeks 0 day to 40 weeks 6 day (full-term), and 41 weeks 0 day to 41 weeks 6 days (late-term). Respiratory distress at birth included respiratory distress syndrome, transient tachypnea, and difficulty in breathing after birth. Univariable and multivariable analyses were performed using logistic regression models with a two-tailed significance level of 5%. All statistical analyses were performed using SAS, version 9.4, for Windows (SAS Institute, Cary, NC). RESULTS: In total, 32 078 of 100 011 (32.1%) neonates had early-term birth. At 37 gestational weeks, 49.7% of the deliveries were via cesarean section, and half of the cesarean deliveries were due to a previous cesarean section. Among the 10 051 neonates born by elective cesarean delivery at term, neonates with early-term births were more likely to have respiratory distress at birth (adjusted odds ratio: 4.19; 95% confidence interval, 1.70, 10.34) than those born at full term. CONCLUSIONS: Early-term birth is associated with a high risk of respiratory distress in births involving cesarean delivery without indication for early delivery. There is a need for guidelines for early delivery considering adverse effects of early-term births.

    File: Health Sci. Rep 2021 Horiuchi S Caesarian delivery and respikratory distress of neonatespdf.pdf

    DOI: 10.1002/hsr2.421

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  • 【消化管の希少疾患-診療の現状】特殊型アカラシア Reviewed

    田中心和, 豊永高史, 阿部洋文, 佐藤裕樹, 塩飽洋生, 南ひとみ, 佐藤千晃, 小川竜, 島村勇人, 横道洋司, 井上晴洋, 児玉裕三

    消化器・肝臓内科   10 ( 3 )   285 - 289   2021.9

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  • Physical and non-physical factors associated with water consumption at the household level in a region using multiple water sources Reviewed International coauthorship

    Ito Y;Kobayashia Y;Yokomichi H;Malla SS;Kieme AS;Nishida K

    Journal of Hydrology-Regional Studies   37   100928 - 100928   2021.9( ISSN:2214-5818 )

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    File: J Hydrol Reg Study 2021 Ito Y Water consumption-associated factors.pdf

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  • Association between preterm birth and maternal allergy considering IgE level Reviewed Major achievement

    Kojima R; Yokomichi H; Akiyama Y; Ooka T; Miyake K; Horiuchi S; Shinohara R; Yamagata Z

    PEDIATRICS INTERNATIONAL   63   1026 - 1032   2021.9( ISSN:1328-8067 )

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  • Prevention Measures for COVID-19 and Changes in Kawasaki Disease Incidence Reviewed

    Katsumata N; Harama D; Toda T; Sunaga Y; Yoshizawa M; Kono Y; Hasebe Y; Koizumi K; Hoshiai M; Saito T; Hokibara S; Kobayashi K; Goto M; Sano T; Tsuruta M; Nakamura M; Mizorogi S; Ohta M; Mochizuki M; Sato H; Yokomichi H; Inukai T; Yamanashi Kawasaki Disease Research Group

    JOURNAL OF EPIDEMIOLOGY   31 ( 11 )   573 - 580   2021.9( ISSN:0917-5040 )

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    BACKGROUND: Kawasaki disease is suspected to be triggered by previous infection. The prevention measures for coronavirus disease 2019 (COVID-19) have reportedly reduced transmission of certain infectious diseases. Under these circumstances, the prevention measures for COVID-19 may reduce the incidence of Kawasaki disease. METHODS: We conducted a retrospective study using registration datasets of patients with Kawasaki disease who were diagnosed in all 11 inpatient pediatric facilities in Yamanashi Prefecture. The eligible cases were 595 cases that were diagnosed before the COVID-19 pandemic (from January 2015 through February 2020) and 38 cases that were diagnosed during the COVID-19 pandemic (from March through November 2020). Incidence of several infectious disease were evaluated using data from the Infectious Disease Weekly Report conducted by the National Institute of Infectious Diseases. RESULTS: Epidemics of various infectious diseases generally remained at low levels during the first 9 months (March through November 2020) of the COVID-19 pandemic. Moreover, the incidence of COVID-19 was 50-80 times lower than the incidence in European countries and the United States. The total number of 38 cases with Kawasaki disease for the 9 months during the COVID-19 pandemic was 46.3% (-3.5 standard deviations [SDs] of the average [82.0; SD, 12.7 cases] for the corresponding 9 months of the previous 5 years. None of the 38 cases was determined to be triggered by COVID-19 based on their medical histories and negative results of severe acute respiratory syndrome coronavirus 2 testing at admission. CONCLUSION: These observations provide a new epidemiological evidence for the notion that Kawasaki disease is triggered by major infectious diseases in children.

    File: J Epidemiol Katsumata Precipitated Kawasaki disease by COVID-19.pdf

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  • Artificial Intelligence Approaches to Type 2 Diabetes Risk Prediction and Exploration of Predictive Factors Reviewed

    Tadao Ooka, Hiroshi Yokomichi, Zentaro Yamagata

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY   50 ( Suppl1 )   dyab168. 515   2021.9( ISSN:0300-5771  eISSN:1464-3685 )

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    DOI: 10.1093/ije/dyab168.51510.1093/ije/dyab168.515

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  • Gestational body weight gain and risk of low birth weight or macrosomia in women of Japan: a nationwide cohort study Reviewed

    Uchinuma H, Tsuchiya K, Sekine T, Horiuchi S, Kushima M, Otawa S, Yokomichi H, Miyake K, Akiyama Y, Ooka T, Kojima R, Shinohara R, Hirata S, Yamagata Z

    INTERNATIONAL JOURNAL OF OBESITY   45 ( 12 )   2666 - 2674   2021.9( ISSN:0307-0565 )

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    DOI: 10.1038/s41366-021-00947-7

    Other Link: https://www.nature.com/articles/s41366-021-00947-7https://www.nature.com/articles/s41366-021-00947-7

  • Factors affecting screw insertion torque in spinal corrective surgery for adult spinal deformity and adolescent idiopathic scoliosis Reviewed

    Ohba T, Oba K, Yokomichi H, Fujita K, Tanaka N, Koyama K, Haro H

    SPINE   46 ( 17 )   E932 - E938   2021.9( ISSN:0362-2436 )

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    File: Text_2021KD4_48.pdf

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  • Temporal directional relationship between problematic Internet use and depressive symptoms among Japanese adolescents: A random intercept, cross-lagged panel model Reviewed

    Kojima R;Shinohara R;Akiyama Y;Yokomichi H;Yamagata Z

    ADDICTIVE BEHAVIORS   120   106989   2021.9( ISSN:0306-4603 )

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    File: Addict Behav 2021 Kojima R Internet use and depression.pdf

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  • All-cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan Cohort Reviewed Major achievement

    Yokomichi H, Mochizuki M, Hirata M, Nagai A, Kojima R, Horiuchi S, Ooka T, Akiyama Y, Shinohara R, Miyake K, BionBank Japan Project, Yamagata Z

    Journal of Diabetes Investigation   12 ( 8 )   1425 - 1429   2021.8( ISSN:2040-1116 )

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    We aimed to determine mortality risk in underweight patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. We analyzed mortality and death‐cause data from BioBank Japan, with baseline years 2003–2007. We analyzed mortality rates from all causes and ischemic heart disease, according to body mass index (<18.5, 18.5–21.9, 22–24.9, and ≥25 kg/m2). Mean (standard deviation) of patients’ age, body mass index, and glycated hemoglobin at enrollment was 61.6 (11.7) years, 25.0 (4.4) kg/m2, and 7.7% (1.5)%, respectively. Hazard ratios of all‐cause and ischemic heart disease mortality were highest (1.79 (p=0.0001) and 2.95 (p=0.027), respectively) in patients with body mass index <18.5 kg/m2, as compared with body mass index 22–24.9 kg/m2. All‐cause mortality risk for body mass index <18.5 kg/m2 was similar to that for current smokers (hazard ratio 1.70, p<0.0001). Underweight could be a predictor of mortality risk in patients with diabetic nephropathy for microalbuminuria or macroalbuminuria.

    File: JDI 2021 Yokomichi H et al. Underweight mortality risk in diabetic nephropathy.pdf

    DOI: 10.1111/jdi.13483

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  • Intranasal administration of 40 and 80IU insulin does not cause hypoglycemia during cardiac surgery: a randomized controlled trial Reviewed International coauthorship

    Nakadate Y, Sato H, Sato T, Wykes L, Kawakami A, Yokomichi H, Matsukawa T, Schricker T

    Canadian Journal of Anesthesia-Journal canadien d anesthesie   68 ( 7 )   991 - 999   2021.7( ISSN:0832-610X )

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    Purpose
    Intranasal insulin administration may improve cognitive function in patients with dementia and may prevent cognitive problems after surgery. Although the metabolic effects of intranasal insulin in non-surgical patients have been studied, its influence on glucose concentration during surgery is unknown.

    Methods
    We conducted a randomized, double-blind, placebo-contolled trial in patients scheduled for elective cardiac surgery. Patients with type 2 diabetes mellitus (T2DM) and non-T2DM patients were randomly allocated to one of three groups (normal saline, 40 international units [IU] of intranasal insulin, and 80 IU intranasal insulin). Insulin was given after the induction of general anesthesia. Glucose and plasma insulin concentrations were measured in ten-minute intervals during the first hour and every 30 min thereafter. The primary outcome was the change in glucose concentration 30 min after intranasal insulin administration.

    Results
    A total of 115 patients were studied, 43 of whom had T2DM. In non-T2DM patients, 40 IU intranasal insulin did not affect glucose concentration, while 80 IU intranasal insulin led to a statistically significant but not clinically important decrease in blood glucose levels (mean difference, 0.4 mMol·L−1; 95% confidence interval, 0.1 to 0.7). In T2DM patients, neither 40 IU nor 80 IU of insulin affected glucose concentration. No hypoglycemia (< 4.0 mMol·L−1) was observed after intranasal insulin administration in any patients. In non-T2DM patients, changes in plasma insulin were similar in the three groups. In T2DM patients, there was an increase in plasma insulin concentrations ten minutes after administration of 80 IU of intranasal insulin compared with saline.

    Conclusions
    In patients with and without T2DM undergoing elective cardiac surgery, intranasal insulin administration at doses as high as 80 IU did not cause clinically important hypoglycemia.

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  • Association of the incidence of atopic dermatitis until 3 years old with birth month and with sunshine duration and humidity in the first 6 months of life: Japan Environment and Children’s Study Reviewed Major achievement

    Yokomichi H, Mochizuki M, Tsuchida A, Kojima R, Horiuchi S, Ooka T, Akiyama Y, Miyake K, Otawa S, Shinohara R, Inadera H, Yamagata Z, Japan Environment and Children’s Study Group

    BMJ Open   11 ( 7 )   e047226   2021.7( ISSN:2044-6055 )

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    OBJECTIVE: To compare the incidence of atopic dermatitis in children aged from 6 months to 3 years across birth seasons and climate conditions. DESIGN: Cohort study. SETTING: Fifteen regional centres across Japan. PARTICIPANTS: A total of 100 304 children born from 2011 to 2014. EXPOSURE: Birth month, and mean sunshine duration (short/long) and humidity (high/low) in the first 6 months of life. PRIMARY OUTCOME MEASURE: Incidence of atopic dermatitis. RESULTS: The highest incidence of atopic dermatitis was in children born in the months of October to December. The lowest incidence of atopic dermatitis was in the months of April to June and in periods with a long duration of sunshine and high humidity. Low humidity was significantly associated with a higher incidence of atopic dermatitis. However, this significant difference disappeared when the birth season and parental history of allergic disease were considered in multivariate analysis. CONCLUSIONS: In Japan, being born in the late autumn to early winter months is associated with a risk of developing atopic dermatitis until the age of 3 years. Sunshine duration and humidity from birth to 6 months of age are not associated with the incidence of atopic dermatitis.

    File: BMJ Open 2021 Yokomichi H et al. Birth month and atopic dermatitis.pdf

    DOI: 10.1136/bmjopen-2020-047226

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  • Random forest approach for determining risk prevention and predictive factors of type 2 diabetes: Large-scale health check-up data in Japan Reviewed

    Ooka T, Johno H, Nakamoto K, Yoda Y, Yokomichi H, Yamagata Z

    BMJ Nutrition, Prevention & Health   4 ( 1 )   140 - 148   2021.6( ISSN:2516-5542 )

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    INTRODUCTION: Early intervention in type 2 diabetes can prevent exacerbation of insulin resistance. More effective interventions can be implemented by early and precise prediction of the change in glycated haemoglobin A1c (HbA1c). Artificial intelligence (AI), which has been introduced into various medical fields, may be useful in predicting changes in HbA1c. However, the inability to explain the predictive factors has been a problem in the use of deep learning, the leading AI technology. Therefore, we applied a highly interpretable AI method, random forest (RF), to large-scale health check-up data and examined whether there was an advantage over a conventional prediction model. RESEARCH DESIGN AND METHODS: This study included a cumulative total of 42 908 subjects not receiving treatment for diabetes with an HbA1c <6.5%. The objective variable was the change in HbA1c in the next year. Each prediction model was created with 51 health-check items and part of their change values from the previous year. We used two analytical methods to compare the predictive powers: RF as a new model and multivariate logistic regression (MLR) as a conventional model. We also created models excluding the change values to determine whether it positively affected the predictions. In addition, variable importance was calculated in the RF analysis, and standard regression coefficients were calculated in the MLR analysis to identify the predictors. RESULTS: The RF model showed a higher predictive power for the change in HbA1c than MLR in all models. The RF model including change values showed the highest predictive power. In the RF prediction model, HbA1c, fasting blood glucose, body weight, alkaline phosphatase and platelet count were factors with high predictive power. CONCLUSIONS: Correct use of the RF method may enable highly accurate risk prediction for the change in HbA1c and may allow the identification of new diabetes risk predictors.

    File: BMJ Nutr Prev 2021 Ooka T Random forest predicts type 2diabetes.pdf

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  • Frequency and clinical characteristics of special types of achalasia in Japan: a large-scale, multicenter database study Reviewed

    Tanaka S;Abe H;Sato H;Shiwaku H;Minami H;Sato C;Ogawa R;Shimamura Y;Yokomichi H;Inoue H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 ( 10 )   2828 - 2833   2021.6( ISSN:0815-9319 )

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    BACKGROUND AND AIM: Achalasia is a rare disease, with an incidence of one in 100 000. Genetic factors and autoimmune involvement have been reported in its etiology, and their involvement is strongly suspected, especially in patients with familial achalasia and those with comorbid hereditary or autoimmune diseases. However, these special types of achalasia are rare, and their frequency and clinical characteristics remain unclear. METHODS: This retrospective, multicenter cohort study included Japanese patients with a diagnosis of achalasia, treated between 2010 and 2019 across six tertiary centers in Japan. The frequency and clinical characteristics of special types of achalasia, namely, familial achalasia, achalasia with a comorbid hereditary disease, and achalasia with a comorbid autoimmune disease, were retrospectively investigated using a large-scale multicenter database. RESULTS: During the study period, 1115 patients were treated for achalasia at six tertiary centers. Familial achalasia, achalasia with a comorbid hereditary disease, and achalasia with a comorbid autoimmune disease occurred in 7 (0.63%), 11 (0.99%), and 27 (2.4%) patients, respectively. Familial achalasia had a slightly younger age of onset (37.6 ± 12.1 years old) and a higher incidence in male patients (six patients; 85.7%). Down's syndrome was the most common hereditary comorbidity, and thyroid disease was the most common autoimmune comorbidity. CONCLUSIONS: We clarified the frequency and clinical characteristics of special types of achalasia. Although special types of achalasia are rare, these comorbidities should be considered when treating patients with achalasia.

    File: J Gastroenterol Hepatol 2021 Tanaka S Special type of achalasiapdf.pdf

    DOI: 10.1111/jgh.15557

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  • Association between gestational hair dye use and allergies at 3 years old: the Japan environment and Children's study Reviewed

    Kojima R, Shinohara R, Horiuchi S, Otawa S, Yokomichi H, Akiyama Y, Ooka T, Miyake K, Yamagata Z

    ENVIRONMENTAL RESEARCH   201   111530 - 111530   2021.6( ISSN:0013-9351 )

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    BACKGROUND: Hair dye use frequently induces allergic contact dermatitis, and on rare occasions induces immunoglobulin E-mediated immediate urticaria, anaphylaxis, and asthma. The effects of hair dye use during pregnancy on offspring have been studied for carcinogenicity, but not for development of allergies. This study aimed to assess the association between hair dye use during pregnancy and allergic disease in children at 3 years old. METHODS: Data of 77,303 participants from the Japan Environment and Children's Study, which is a prospective birth cohort recruited from January 2011 to March 2014, were used. We examined the associations between using hair dye during pregnancy and allergic diseases (food allergy, asthma, atopic dermatitis and allergic rhinitis) in children after adjustment for covariates by multivariable logistic regression. RESULTS: Among mothers who were exposed to hair dye during pregnancy, 50.0% were exposed in hair salons, 21.3% had home use, and 9.5% had occupational exposure. The percentages of doctor-diagnosed allergies at 3 years old were 6.3% for food allergies, 7.7% for asthma, 7.3% for atopic dermatitis, and 4.6% for allergic rhinitis. In univariable analyses, hair dye use at home and occupational exposure was significantly associated with asthma respectively (odds ratio [OR] 1.15, 95% CI 1.07-1.24 for at home; OR 1.18, 95% CI 1.08-1.28 for occupational exposure). Hair dye use at home were significantly associated with doctor-diagnosed allergic rhinitis at 3 years old (OR 1.12, 95% CI 1.02-1.22). After adjustment for covariates, these associations for asthma decreased and were no longer significant (aOR 1.06, 95% CI 0.98-1.14 for at home; aOR 1.09, 95% CI 1.00-1.20 for occupational exposure, p = 0.057), also for allergic rhinitis (aOR 1.07, 95% CI 0.97-1.19). Doctor-diagnosed allergic rhinitis at 3 years old was significantly associated with hair dye use at home in the most frequent use group (aOR for quite often versus never 1.78, 95% CI 1.22-2.60). CONCLUSION: Both home and occupation use of hair dye during pregnancy showed a trend of increased odds of allergic rhinitis and asthma in offspring at 3 years. However, the only association that reached significance was in frequency of use analyses between the highest frequency of home hair dye users and allergic rhinitis.

    File: Environ Res 2021 Kojima R Hair dye and allergies at 3 years old JECS.pdf

    DOI: 10.1016/j.envres.2021.111530

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  • Association between preterm birth and maternal allergy considering IgE level Reviewed

    Kojima R;Yokomichi H;Akiyama Y;Ooka T;Miyake K;Horiuchi S;Shinohara R;Yamagata Z

    PEDIATRICS INTERNATIONAL   63   1026 - 1032   2021.6( ISSN:1328-8067 )

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    DOI: 10.1111/ped.14635

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  • Changes in height standard deviation scores during early life are affected by nutrition Reviewed

    Tanaka T, KatoN, Yokoya S, Ono A, Isojima T, Yokomichi H, yamagata Z, Tanaka S, Matsubara H, Ishikuro M, Kikuya M, Hosoya M, Chida S, Kuriyama S, Kure S

    Pediatrics International   63 ( 6 )   710 - 715   2021.6( ISSN:1328-8067  eISSN:1442-200X )

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    File: Pediatr Int 2020 Tanaka T Height SDS change in Japan.pdf

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  • Association between the point-rating system used for oral health and the prevalence of Gram-negative bacilli in hematological inpatients: A retrospective cohort study Reviewed

    Yoshizawa K;Akinori Moroi A;Iguchi R;Yokomichi H;Ogihara S;Nakajima K;Kirito K;Ueki K

    MEDICINE   100   e26111   2021.6( ISSN:0025-7974 )

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    File: Medicine 2021 Yoshizawa K Point-rating system for oral health.pdf

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  • Difference and variance in nutrient intake by age for older adults living alone in Japan: comparison of dietary reference intakes for the Japanese population Reviewed

    Ishikawa M;Yokomichi H;Yokoyama T

    Nutrients   13 ( 5 )   1431   2021.4( ISSN:2072-6643  eISSN:2072-6643 )

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    This study aimed to estimate the distribution of usual intakes in protein, sodium, potassium, and calcium by age group and assessed whether proportions of deficiencies/excesses of each nutrient would occur more in older age via a comparison with the dietary reference intakes for the Japanese population (DRIs_J). A cross-sectional analysis was conducted using a database of the 2-day nutrient intake of 361 Japanese people aged 65-90 years. The AGEVAR MODE was used to estimate usual intake. Percentile curves using estimated distribution by sex and age and usual nutrient intake were compared to those of the DRIs_J. The usual intake of protein (male and female) and potassium and calcium (female) were lower with older age. Within-individual variance of protein in female (p = 0.037) and calcium in male (p = 0.008) subjects were considerably lower with older age. The proportion of deficiencies in protein (male and female), potassium (female), and calcium (female) were higher with older age. However, the proportion of people with excess salt (converted from sodium; male and female) did not differ by age. The variances found herein could be important for enhancing the understanding of differences in dietary intake by age.

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  • Achalasia and esophageal cancer - a large database analysis in Japan Reviewed

    Sato H, Terai S, Shimamura Y, Tanaka S, Shiwaku H, Minami H, Sato C, Ogawa R, Yokomichi H, Inoue H

    Journal of Gastroenterology   56 ( 4 )   360 - 370   2021.4( ISSN:0944-1174 )

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    BACKGROUND: Achalasia has been reported to be associated with esophageal cancers (ECs). However, owing to the rarity of achalasia, details of achalasia-related ECs are not well investigated. METHOD: The incidence of ECs in Japanese patients with achalasia and achalasia-related esophageal motility disorders (EMDs) was estimated, and risk factors for achalasia-related ECs were determined. Characteristics of ECs and treatment courses were also analyzed. RESULTS: Between 2010 and 2019, 2714 Japanese patients with achalasia and achalasia-related EMDs were recorded in 7 high-volume centers; 24 patients (21 men, 3 women) developed ECs. The incidence of ECs was estimated at 0.078 and 0.28 per 100 person-years from the onset and the diagnosis of disease, respectively. Kaplan-Meier estimate suggested that, in addition to a long history of achalasia, advanced age, male sex, and regular alcohol consumption were statistically significant risk factors for EC development. A prevalence of 40 ECs (12.5% multiple lesions, and 22.7% metachronal lesions) was also noted, predominantly distributed over the thoracic esophagus. All were histologically diagnosed as squamous cell carcinoma. Superficial ECs were successfully treated with endoscopic treatment in all cases, except one. Achalasia-related Barret esophagus was extremely rare, and Barret adenocarcinoma was not detected in our cohort. CONCLUSION: The high relative risk of ECs was clarified in Japanese achalasia patients, although the absolute risk remained low. Therefore, surveillance endoscopy may be recommended in limited patients with several aforementioned risk factors determined. Superficial cancer can be treated with endoscopic treatment. Multiple and metachronal ECs should be screened.

    File: J Gastroenterol 2021 Sato H Achalasia and esophageal cancer in Japan.pdf

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  • Incidence of childhood type 1 diabetes mellitus in Yamanashi Prefecture, Japan, 1986–2018 Reviewed

    Saito T, Kobayashi K, Kobayashi K, Mochizuki M, Yagasaki H, Makino K, Narusawa H, Watanabe D, Mitsui Y, Sato K, Sano T, Ohta, M, Yokomichi H, Amemiya S

    Endocrine, Diabetes & Metabolism   4 ( 2 )   e00214   2021.4( ISSN:2398-9238 )

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    Introduction: Several studies have examined the incidence of childhood T1DM in Japan from the 1970s onwards, but none have been long-term studies using registration data. We estimate the incidence of childhood type 1 diabetes mellitus (T1DM) from 1986 to 2018 in Yamanashi Prefecture, Japan. Methods: We began a population-based, long-term study of childhood T1DM in 1986 involving every hospital paediatrics department in Yamanashi Prefecture. In the Prefecture, every child newly diagnosed with T1DM is referred to a hospital, and therefore, almost 100% of new patients aged <15 years are registered. We calculated the incidence of T1DM among children aged <15 years from 1986 to 2018. All cases met the Japan Diabetes Society diagnostic criteria and were tested for T1DM-related autoantibodies whenever possible. Results: Ninety-nine patients (44 boys and 55 girls) were newly diagnosed with T1DM. The annual incidence among 5- to 9-year-olds increased by 5.35% over the study period (95% confidence interval 2.34%-8.35%, p = .0005), and there was a trend towards increasing 3-year incidence (15.52% increase, p = .0516). There were also trends towards increasing annual and 3-year incidence among 0- to 14-year-olds. However, there were no changes over time in annual or 3-year incidence in the 0-4 year or 10-14 year age groups. Conclusions: The incidence of T1DM in Yamanashi Prefecture increased among children aged 0-14 years over the study period, with the most significant increase occurring among 5- to 9-year-olds. These data suggest that the number of children aged <15 years with T1DM is gradually increasing in one of the local prefectures in Japan, Yamanashi Prefecture and that the age of onset is decreasing.

    File: Endocrinol Diabetes Metab 2020 Saito T T1DM incidence in Yamanashi.pdf

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  • Encouraging cross-disciplinary collaboration and innovation in epidemiology in Japan Reviewed Major achievement

    Yokomichi H, Mochizuki M, Yamagata Z

    Frontiers in Public Health   9   641882 - 641882   2021.3( ISSN:2296-2565 )

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    Background: Scientific innovation is often achieved through the intersection of ideas from different fields. However, barriers prevent non-epidemiologists from cultivating interests in epidemiology or undertaking epidemiologic work. In this study, we evaluated changes in the diversity of research topics in an epidemiologic journal over time. We aimed to understand how epidemiologists and non-epidemiologists communicate about epidemiologic data and how this impacts innovation in the field. Methods: We categorized the topics of articles published in the Journal of Epidemiology during the early and late 2010s based on their titles. We calculated the Shannon-Weaver diversity index (H') to measure changes in the diversity of topics addressed by published articles. Results: Comparing 2011-2013 with 2017-2019, there was no significant change in the diversity of article topics (H' = 4.25 and 4.21, respectively) published in the Journal of Epidemiology. Conclusion: To encourage healthcare providers and public administrators to conduct or comment on epidemiologic studies, epidemiologists should present their findings in easily understood language with appropriate and relevant statistical indicators and useful illustrations. Bringing experience from other specialties into epidemiology may yield new findings from epidemiologic data because of the exposure of non-epidemiologists to different values, workplaces, and occupations. Collaboration among professionals from varied backgrounds and with varied occupational experiences may help to promote scientific innovation by broadening perspectives. In addition, a range of professional experiences may enable individuals to solve difficult research questions more easily by themselves.

    File: Frontiers Public Health 2021 Yokomichi H et al. Innovation in epidemiology.pdf

    DOI: 10.3389/fpubh.2021.641882

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  • Koshu GRoup activity, Active Play, and Exercise (GRAPE) study: A cluster randomised controlled trial protocol of a school-based intervention among Japanese children Reviewed

    Yamakita M, Ando D, Sugita H, Akiyama Y, Sato M, Yokomichi H, Yamaguchi K, Yamagata Z

    International Journal of Environmental Research and Public Health   87 ( 7 )   3351   2021.3( ISSN:1661-7827 )

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    School-based programmes need to be effective, easy for all, easy to perform within a short duration, and inexpensive. However, no studies have reported whether voluntarily and very short-time active play programmes contribute to improved health outcomes. This study aims to describe the GRoup activity, Active Play and Exercise (GRAPE) cluster randomised controlled trial that examined whether active play interventions of very short durations contribute to increasing physical activity (PA) and bone mass among school-aged children. The trial was conducted in 2018 from January to June, and the activity comprised ≥2 children jumping together for approximately 10 s per session, at least five times a day (approximately 1 min/day). School clusters, pair-matched as per school size (total number of children) and region, were randomly allocated to either intervention or wait-list control groups. The primary outcomes comprised objectively measured changes in PA levels (moderate-to-vigorous PA) evaluated using wrist-worn activity trackers from baseline to the one-year follow-up (six-month post-intervention follow-up) and changes in bone mass evaluated using calcaneus quantitative ultrasound parameters. This study could describe the problems and challenges in school-based PA intervention studies and present findings that could make a potentially important contribution to health education and PA promotion.

    File: Int J Environ Pes Public Health 2021 Yamakita M Protocol of GRAPE Study.pdf

    DOI: 10.3390/ijerph18073351

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  • Effectiveness of influenza vaccination in infants and toddlers with and without prior infection history: The Japan Environment and Children’s Study Reviewed Major achievement

    Yokomichi H, Kojima R, Horiuchi S, Ooka T, Akiyama Y, Miyake K, Mochizuki M, Otawa S, Shinohara R, Yamagata Z, The Japan Environment and Children’s Study Group

    VACCINE   39 ( 13 )   1800 - 1804   2021.3( ISSN:0264-410X )

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    We calculated the Poisson-regression-adjusted relative risk (RR) of new influenza infection by vaccination, prior infection, and vaccination after prior infection in a large Japanese birth cohort, using data from ≤89,253 children aged 6 months to 3 years. The effectiveness of risk reduction (1 - RR) by vaccination at ages 1.5-3 years was 21%-31%. The RR of new infection after prior infection vs. no prior infection was 2.58-19.3 at age 1-3 years. An analysis of the 1 - RR data stratified by having at least one senior sibling and/or attending nursery school revealed that vaccination reduced the RR by 22%-40%. The 1 - RR of new infection was 21% in 3-year-old children who were vaccinated after prior infection. All these findings are statistically significant. The results consistently indicate that, regardless of having at least one senior sibling, attending nursery school, and/or being previously infected with influenza, infants and toddlers will benefit from influenza vaccination.

    File: Vaccine 2021 Yokomichi H et al. Influenza vaccine effectiveness after prior infection.pdf

    DOI: 10.1016/j.vaccine.2021.02.044

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    Other Link: https://www.sciencedirect.com/science/article/pii/S0264410X21002243

  • 5歳児のテレビ視聴と睡眠, 母親の就労25年間の推移:甲州市母子保健縦断調査より Reviewed

    小島令嗣, 秋山有佳, 佐藤美理, 大岡忠生, 三宅邦夫, 横道洋司, 山縣然太朗

    小児保健研究   80 ( 1 )   92 - 96   2021.2

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    Other Link: https://www.jschild.or.jp/research/archive/

  • Association between accelerometer-measured physical activity and falls among community-dwelling older people living in cold, snowy areas Reviewed

    Kojima R, Ukawa S, Yokomichi H, Tanaka A, Kimura T, Amagasa S, Inoue S, Kondo K, Tamakoshi A

    European Geriatric Medicine   12   91 - 98   2021.2( ISSN:1878-7649  eISSN:1878-7657 )

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    Aim
    To investigate the association between falls and accelerometer measured physical activity among older people living in cold, snowy regions in Japan.

    Findings
    A higher moderate-to-vigorous intensity physical activity levels and walking steps were associated with falls on a frozen road.

    Message
    The risk of falls, especially on frozen roads, increased among active older people living in cold, snowy regions, and environmental factors should be considered when determining prevention strategies.

    File: Eur Geriatr Med 2020 Kojima R et al. Physical activity and fal on snow.pdf

    DOI: 10.1007/s41999-020-00398-9

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  • Endothelial lipase exerts its anti-atherogenic effect through increased catabolism of beta-VLDLs Reviewed

    Yan H, Niimi M, Wang C, Chen Y, Zhou H, Matsuhisa F, Nishijima K, Kitajima S, Zhang B, Yokomichi H, Nakajima K, Murakami M, Zhang J, Y. Chen E, Fan J

    Journal of Atherosclerosis and Thrombosis   28 ( 2 )   157 - 168   2021.2( ISSN:1340-3478  eISSN:1880-3873 )

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    © 2021 Japan Atherosclerosis Society. Aim: Endothelial lipase (EL) plays an important role in lipoprotein metabolism. Our recent study showed that increased hepatic expression of EL attenuates diet-induced hypercholesterolemia, thus subsequently reducing atherosclerosis in transgenic (Tg) rabbits. However, it is yet to be determined whether increased EL activity itself per se is anti-atherogenic or whether the anti-atherogenic effect of EL is exclusively dependent on its lipid-lowering effect. Methods: To determine the mechanisms underlying EL-mediated anti-atherogenic effect, we fed Tg and non-Tg rabbits diets containing different amounts of cholesterol to make their plasma cholesterol levels similarly high. Sixteen weeks later, we examined their lipoprotein profiles and compared their susceptibility to atheroscle-rosis. Results: With Tg and non-Tg rabbits having hypercholesterolemia, the plasma lipids and lipoprotein profiles were observed to be similar, while pathological examinations revealed that lesion areas of both aortic and coronary atherosclerosis of Tg rabbits were not significantly different from non-Tg rabbits. Moreover, Tg rabbits exhibited faster clearance of DiI-labeled β-VLDLs than non-Tg rabbits. Conclusion: The results of our study suggest that the enhancement of β-VLDL catabolism is the major mechanism for atheroprotective effects of EL in Tg rabbits.

    File: J Atheoscler Thromb 2020 Yan H, Niimi M Endothelial lipase function through beta-VLDL catabolism .pdf

    DOI: 10.5551/jat.55244

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  • Cause-specific mortality rates in patients with diabetes according to comorbid macro- and microvascular complications: BioBank Japan Cohort Reviewed Major achievement

    Yokomichi H, Nagai A, Hirata M, Mochizuki M, Kojima R, Yamagata Z on behalf of BioBank Japan Project

    Endocrine, Diabetes & Metabolism   27 ( 4 )   e00181   2021.1( ISSN:2398-9238 )

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    Patients with diabetic nephropathy have the highest mortality rates of all causes, cancer, and macrovascular and infectious diseases. The primary cause of death of patients with diabetes with and without all vascular complications was cancer. The cancer mortality rate was similar, regardless of whether vascular complications were present.

    File: Endocrionol Diab Metab 2020 BBJ T2DM vascular complication and mortality.pdf

    DOI: 10.1002/edm2.181

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    Other Link: https://onlinelibrary.wiley.com/doi/10.1002/edm2.181

  • Correction: Caregivers' mental distress and child health during the COVID-19 outbreak in Japan.

    Sayaka Horiuchi, Ryoji Shinohara, Sanae Otawa, Yuka Akiyama, Tadao Ooka, Reiji Kojima, Hiroshi Yokomichi, Kunio Miyake, Zentaro Yamagata

    PloS one   16 ( 4 )   e0250191   2021

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    [This corrects the article DOI: 10.1371/journal.pone.0243702.].

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  • Caregivers’ mental distress and child health during the COVID-19 outbreak in Japan Reviewed

    Horiuchi S, Shinohara R, Otawa S, Akiyama Y, Ooka T, Kojima R, Yokomichi H, Miyake K, Yamagata Z

    PLoS One   15 ( 2 )   e0243702   2020.12( ISSN:1932-6203 )

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    DOI: https://doi.org/10.1371/journal.pone.0243702

    Other Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243702

  • Increasing secular trends in height and obesity in children with type 1 diabetes: JSGIT cohort Reviewed

    Mochizuki M, Ito Y, Yokomichi H,Kikuchi T, Soneda S, Musha I, Anzou M, Kobayashi K, Matsuo K, Sugihara S, Sasaki N, Matsuura N, Amemiya S

    PLoS One   15 ( 11 )   e0242259   2020.11( ISSN:1932-6203 )

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    BACKGROUND: Recently, anthropometric indices in children with type 1 diabetes mellitus (T1DM) have begun to change. OBJECTIVE: To examine secular trends in patients' anthropometric indices. SUBJECTS: Japanese children with T1DM from the 1995, 2000, 2008 and 2013 cohorts of The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes. METHODS: We analysed serum haemoglobin A1c (HbA1c) levels, the incidence of severe hypoglycaemic events, the types and doses of insulin, height standard deviation scores (SDS), body mass index (BMI) percentiles compared with healthy Japanese children and obesity prevalence over time. We also stratified the patients according to glycaemic control levels of <58 mmol/mol (optimal), 58-75 mmol/mol (suboptimal) and ≥75 mmol/mol (high-risk). RESULTS: Data for 513-978 patients from each of the cohorts were analysed. The incidence of severe hypoglycaemic events decreased over time (from 21 to 4.8/100 patient-years), while the proportion of insulin analogue doses increased (14.6% to 98.6%). In addition, patient height SDS (-0.22 to +0.17), BMI percentile (52.1 to 58.7) and obesity prevalence (2.1% to 5.1%) increased. Height SDS increased in all of the glycaemic control subgroups, while BMI percentile and obesity prevalence increased in the suboptimal and high-risk groups. CONCLUSIONS: Since 1995, the average height of children with T1DM has increased in parallel with increasing insulin doses. Clinicians should be aware of increased BMI in these patients and the associated risk of developing cardiovascular disease in the future.

    File: PLoS One 2020 Mochizuki M Increase in height and obesity in Japanese T1DM.pdf

    DOI: 10.1371/journal.pone.0242259

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  • Association between the point‑rating system used for oral health and the prevalence of pneumonia‑causing bacteria in malnourished patients Reviewed

    Yoshizawa K, Fujimura T, Kawashiri S, Tokumaru T, Toyama T, Yokomichi H, Moroi A, Ueki K

    International Journal of Functional Nutrition   1 ( 2 )   1 - 8   2020.11( ISSN:2634-7989 )

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    Despite the importance of oral care in the prevention of aspiration pneumonia, the association between oral hygiene and the prevalence of pneumonia‑causing bacteria has not yet been determined. The present study is a cross‑sectional study aimed at determining the association between the original point‑rating system used during oral examinations (the prompt non‑invasive oral assessment) and the prevalence of pneumonia‑causing bacteria in a population of hospitalized patients with malnutrition. The nutrition support team cared for 61 patients; 6 were excluded as they were not eligible. Bedside analyses were conducted using the point‑rating system. The findings were analyzed to determine the association between the prompt non‑invasive oral assessment and the detection of pneumonia‑causing bacteria. Patients who tested positive for pneumonia‑causing bacteria (n=13) received significantly higher total and hygiene item scores than those who tested negative (n=42) [median (25th, 75th percentile), total score, 6 (4, 7) vs. 3 (1, 5), P=0.02; hygiene score, 2 (1, 3) vs. 1 (0, 2), P=0.02]. In the receiver operating characteristic analysis, a total oral assessment cut‑off score of 4 was identified as optimal for detecting pneumonia‑causing bacteria. Additionally, a multivariable analysis revealed a high odds ratio for the presence of pneumonia‑causing bacteria in patients with poor oral hygiene (odds ratio, 2.09; 95% CI, 1.04 to 4.22). Thus, the present study demonstrates that the prompt non‑invasive oral assessment is a simple and effective tool for detecting pneumonia‑causing bacteria in hospitalized patients.

    File: Int J Funct Nutr 2020 Yoshizawa K Point rating for oral health and bacterial pneumonia.pdf

    DOI: 10.3892/ijfn.2020.8

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  • 糖尿病性腎症患者におけるBMIと死亡率の関係 バイオバンク・ジャパンコホート

    横道 洋司, 小島 令嗣, 堀内 清華, 大岡 忠生, 山縣 然太朗

    日本公衆衛生学会総会抄録集   79回   239 - 239   2020.10( ISSN:1347-8060 )

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  • Farm working experience could reduce late-life dependency duration among Japanese older adults: the Yamanashi Healthy-Active Life Expectancy cohort study based on the STROBE guidelines Reviewed Major achievement

    Haruyama K, Yokomichi H, Yamagata Z

    Medicine   99 ( 38 )   e22248   2020.9( ISSN:0025-7974 )

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    Objective: With the advance of medical care, the duration of dependency on nursing care in later life has increased worldwide. There is a question of whether farm work could extend or shorten the dependency duration. We investigated the association between farm work experience and the duration of dependency on nursing support or care in late life.

    Methods: We randomly selected 600 adults aged ≥ 65 years, who were independent and not hospitalized, as part of the Yamanashi Healthy–Active Life Expectancy cohort and
    followed them for 13 years. We defined the duration of dependency as the time from
    reception of long-term care insurance benefits to death, and we adjusted for multiple
    covariates.

    Results: We analyzed data from 225 adults (139 men and 86 women) who died during the
    follow-up period. Ninety-four had received long-term care benefits. Mean age was 79.6
    years (standard deviation [SD]: 6.3) in individuals with farm work experience and 80.1
    years (SD: 7.2) in individuals without farm work experience. The estimated duration of
    dependency on long-term care was 1.3 years (standard error [SE]: 0.4) in individuals
    with farm work experience vs. 2.1 years (SE: 0.5) in individuals without farm work
    experience (p = .01). The estimated duration of dependency in individuals with farm
    work experience and without farm work experience was 0.4 years (SE: 0.5) vs. 1.3
    years (SE: 0.6) in men respectively (p = .03) and 1.6 years (SE: 0.9) vs. 2.4 years (SE:
    0.9) in women, respectively (p = .16). The sensitivity analysis yielded an estimated
    duration of 1.2 years (SE: 0.5) in those with farm work experience and 2.3 years (SE:
    0.5) in those without farm work experience (p = .004).

    Conclusion: Individuals with farm work experience required less long-term care prior to death, suggesting that agricultural and physical activities promote health. Policymakers
    focusing on preventing the need for nursing care in older populations could consider
    promoting farming or gardening.

    File: Medicine 2020 Haruyama K et al. Farm work reduces late life duration.pdf

    DOI: 10.1097/MD.0000000000022248

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  • Factors affecting postoperative mortality of patients with insufficient union following osteoporotic vertebral fractures and impact of preoperative serum albumin on mortality Reviewed Major achievement

    Ohba T, Yokomichi H, Koyama K, Tanaka N, Oda K, Haro H

    BMC MUSCULOSKELETAL DISORDERS   21 ( 1 )   1 - 7   2020.8( ISSN:1471-2474 )

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    DOI: 10.21203/rs.2.18119/v310.21203/rs.2.18119/v3

    Other Link: https://link.springer.com/article/10.1186/s12891-020-03564-z

  • Concordance and discordance rates of BRAFV600E status in metastatic against primary lesion of melanoma: a meta-analysis Reviewed Major achievement

    Yokomichi H and Inozume T (co-first authors), Wada M, Asai J, Igaki H, Namikawa K, Hayashi A, Fukushima S, Fujiwara T, Koga H, Namikawa Y, Mochizuki M, Yamagata Z

    JMA Journal   3 ( 3 )   274 - 279   2020.7( ISSN:2433-328X )

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    File: JMA J 2020 Concordance and discordance of BRAF in metastatic vs. primary lesion of melanoma.pdf

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  • Prevalence of and factors associated with unplanned pregnancy among women in Koshu, Japan: cross-sectional evidence from Project Koshu, 2011–2016 Reviewed Major achievement

    Huynh ST, Yokomichi H, Akiyama Y, Kojima R, Horiuchi S, Ooka T, Shinohara R, Yamagata Z

    BMC Pregnancy and Childbirth   20 ( 1 )   e397 - 397   2020.7( ISSN:1471-2393 )

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    Background
    Unplanned pregnancy is a public health issue with adverse consequences for maternal and neonatal health. In Japan, the prevalence of unplanned pregnancy was 46.2% in 2002. However, few studies have investigated this topic, and there is little recent data from Japan. We described and examined the prevalence and determinants of unplanned pregnancy among rural women in Japan from 2011 to 2016.

    Methods
    We used cross-sectional data from a community-based cohort study (Project Koshu). Data were collected from 2011 to 2016 via a self-report questionnaire included in the Maternal and Child Health Handbook of Japan. Pregnancy intention was measured as a binary variable (planned or unplanned). Univariate and multivariate logistic regression analyses were performed to examine factors associated with unplanned pregnancy, with results reported as odds ratios (ORs) and 95% confidence intervals (CIs). We conducted sensitivity analyses with different definitions of pregnancy intention to assess the robustness of the results. The significance level was set at 5%.

    Results
    Of the 932 participants (mean ± standard deviation age at baseline: 31.3 ± 5.2 years), 382 (41%) pregnancies were reported as unplanned. The multivariate analyses showed that maternal age (+ 1 year: OR = 0.94, 95% CI: 0.92–0.97, p <  0.001), ‘other’ family structure (OR = 2.76, 95% CI: 1.12–6.76, p = 0.03), three or more pregnancies (OR = 2.26, 95% CI: 1.66–3.08, p <  0.001), current smoking (OR = 2.60, 95% CI: 1.26–5.35, p = 0.01), balanced diet (OR = 0.62, 95% CI: 0.47–0.83, p <  0.001) and current depression (OR = 1.63, 95% CI: 1.24–2.16, p <  0.001) were strongly associated with unplanned pregnancy. These associations were consistent across definitions of pregnancy intention, supporting the robustness of our results.

    Conclusions
    The prevalence of unplanned pregnancy in the study population was high (41%). Risk factors for unplanned pregnancy were age, number of pregnancies, smoking, having a balanced diet and current depression. These results suggest greater efforts are needed to enhance sex education for young people, improve access to family planning services and provide comprehensive health care for high-risk women to help reduce unplanned pregnancies.

    File: BMC Pregnancy Childbirth 2020 Huynh ST Prevalence of unplanned pregnancy from Project Koshu.pdf

    DOI: 10.1186/s12884-020-03088-3

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  • Weekly teriparatide versus bisphosphonate for bone union during six months after multi-level lumbar interbody fusion for osteoporotic patients: a multicenter, prospective, randomized study Reviewed

    Oba H, Takahashi J, Yokomichi H, Hasegawa T, Ebata S, Mukaiama K, Ohba T, Ushirozako H, Kuraishi S, Ikegami S, Uehara M, Takizawa T, Munakata R, Hatakenaka T, Matsuyama Y, Haro H

    SPINE   45 ( 13 )   863 - 871   2020.7( ISSN:0362-2436 )

  • Risk factors and assessment using an endoscopic scoring system for early and persistent dysphagia after anterior cervical decompression and fusion surgery Reviewed

    Ohba T, Hatsushika K, Ebata S, Koyama K, Akaike H, Maruyama K, Yokomichi H, Haro H

    Clinical Spine Surgery   33 ( 4 )   E168 - E173   2020.5( ISSN:2380-0186 )

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    DOI: 10.1097/BSD.0000000000000945

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  • Peroral endoscopic myotomy to treat esophageal achalasia: A prospective multicenter study performed in Japan Reviewed Major achievement

    Shiwaku H, Inoue H, Sato H, Onimaru M, Minami H, Tanaka S, Sato C, Ogawa R, Okumura N, Yokomichi H

    Gastrointestinal Endoscopy   91 ( 5 )   1037 - 1044   2020.5

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    BACKGROUND AND AIMS: Peroral endoscopic myotomy (POEM) is an available treatment modalities for achalasia. The reported efficacy of POEM in the only prospective multicenter study was 82%; however, a retrospective multicenter study in Japan reported a higher efficacy rate of 95%. The aim of this study was to prospectively verify treatment outcomes after POEM at multiple facilities in Japan. METHODS: This was a prospective single-arm trial of POEM for achalasia at 8 facilities in Japan between April 2016 and March 2018 to evaluate its safety and efficacy. Patients were re-evaluated at 3 months and up to 1 year after POEM. RESULTS: Among the 233 patients with achalasia who underwent POEM, procedure-related adverse events occurred in 24 patients (10.3%), none of whom required surgical intervention. In the 207 patients satisfying the inclusion criteria, the efficacy rate of POEM, defined by an Eckardt score ≤3 at 1 year, was 97.4% (95% CI, 95.3%-99.7%). The Eckardt score decreased significantly from 6.6 ± 2.0 preoperatively to 1.1 ± 1.1, 1 year after POEM. Postoperative reflux esophagitis, severe reflux esophagitis, and symptomatic GERD were reported in 54.2%, 5.6%, and 14.7%, respectively, and proton pump inhibitors were administered in 21.1%. CONCLUSIONS: Our prospective multicenter study in Japan showed greater efficacy of POEM for achalasia compared with the results of a previous prospective multicenter study. POEM is safe and highly effective for at least 1 year. (Clinical trial registration number: UMIN 000021550.).

    File: Gastrointestinal Endoscopy 2020 Shiwaku H et al. Prognosis of achalasia in Japan.pdf

    DOI: 10.1016/j.gie.2019.11.020

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    Other Link: https://www.giejournal.org/article/S0016-5107(19)32470-8/fulltext

  • Immune thrombocytopenic purpura risk by live, inactivated and simultaneous vaccinations among Japanese adults, children and infants: a matched case–control study Reviewed Major achievement

    Yokomichi H, Tanaka-Taya K, Koshida R, Nakano T , Yasui Y, Mori M, Ando Y, Morino S, Okuno H, Satoh H, Arai S, Mochizuki M, Yamagata Z

    International Journal of Hematology   112 ( 1 )   105 - 114   2020.4( ISSN:0925-5710 )

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    This case-control study investigated immune thrombocytopenic purpura (ITP) risk following live, inactivated, and simultaneous vaccination, with a focus on infants aged < 2 years. We matched case patients with ITP to one or two control patients with other diseases by institution, hospital visit timing, sex, and age. We calculated McNemar's pairwise odds ratios (ORs [95% confidence interval]) with 114 case-control pairs. The case group had 27 (44%) males and 22 (35%) infants, and the control group included 49 (43%) males and 42 (37%) infants. For all age groups, the McNemar's OR for ITP occurrence was 1.80 (0.54-6.84, p = 0.64) for all vaccines. Among infants, these were 1.50 (0.17-18.0, p = 0.50) for all vaccines, 2.00 (0.29-22.1, p = 0.67) for live vaccines, and 1.00 (0.01-78.5, p = 0.50) for inactivated vaccines. Sex-adjusted common ORs for simultaneous vaccination were 1.52 (0.45-5.21, p = 0.71) for all vaccines, 1.83 (0.44-7.59, p = 0.40) for inactivated vaccines only, and 1.36 (0.29-6.30, p = 0.69) for mixed live and inactivated vaccines. In infants, these were 1.95 (0.44-8.72, p = 0.38), 1.41 (0.29-6.94, p = 0.67) and 2.85 (0.43-18.9, p = 0.28), respectively. These limited data suggest no significant ITP risk following vaccinations or simultaneous vaccination in any age group, including infants.

    File: Int J Hematol 2020 ITP risk by inactivated and simultaneous vaccinations.pdf

    DOI: 10.1007/s12185-020-02866-1

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  • Variations of small bowel transit time on capsule endoscopy Reviewed

    Tominaga K, Sato H, Yokomichi H, Tsuchiya A, Yoshida T, Kawata Y, Yokoyama J, Terai S

    Annals of Translational Medicine   8 ( 6 )   348 - 348   2020.3( ISSN:2305-5839 )

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    Background: Small bowel motility remains inadequately understood because of the complex and various functions as well as its anatomical position. The aimed of the study was to investigate the small bowel transit time (SBTT) of capsule endoscopy (CE) and to analyze the clinical factors affecting SBTT. Methods: SBTT was analyzed in patients who underwent small bowel CE. Factors contributing to SBTT and CE retention were investigated. Results: Among 397 patients enrolled in this study, 336 (84.6%) completed CE. The mean SBTT (± standard deviation) was 282.1±132.2 min. According to the univariate and multivariate analyses, aging and small bowel stenosis extended SBTT. In 38 patients who underwent multiple CE studies, considerable variation in SBTT were observed [mean of standard deviations (SDs) =97.97 min, SD of the SDs =81.99 min]. CE retention was observed in 61 patients (13.3%), and it was statistically associated to small bowel lesion. Conclusions: Aging and small bowel stenosis were associated with longer SBTT. Furthermore, SBTT analyzed by CE should be interpreted carefully considering the intra-individual differences in SBTT.

    File: Ann Transl Med 2020 Tominaga K et al. Capsule endoscopy transit time variation.pdf

    DOI: 10.21037/atm.2020.02.40

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  • Travel time to hospital/clinic and risk of death or nursing care in Japanese community-dwelling elderly adults: Y-HALE Cohort Study Reviewed Major achievement

    Xiao Huang and Hiroshi Yokomichi (co-first authors), Zentaro Yamagata

    Yamanashi Medical Journal   34 ( 1 )   1 - 15   2020.2

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    Other Link: https://yamanashi.repo.nii.ac.jp/index.php?action=pages_view_main&active_action=repository_view_main_item_snippet&index_id=206&pn=1&count=20&order=7&lang=japanese&page_id=30&block_id=67

  • Life expectancy with care needs is shorter in aged adults experiencing farm work. - Y-HALE study - Reviewed Major achievement

    Zentaro Yamagata, Hiroshi Yokomichi, Kayo Haruyama

    AMERICAN JOURNAL OF PUBLIC HEALTH   2020.2( ISSN:0090-0036 )

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    Other Link: https://apha.confex.com/apha/2019/meetingapp.cgi/Paper/447242

  • インフルエンザ罹患時に外来で抗生剤を投与する事と肺炎により入院する期間との関係

    横道 洋司, 望月 美恵, 小島 令嗣, 堀内 清華, 山縣 然太朗

    日本小児科学会雑誌   124 ( 2 )   219 - 219   2020.2( ISSN:0001-6543 )

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  • 小児インフルエンザ患者における抗菌剤の併用と入院率の関連

    望月 美恵, 横道 洋司, 太田 正法, 犬飼 岳史, 堀内 清華, 小島 令嗣, 山縣 然太朗

    日本小児科学会雑誌   124 ( 2 )   219 - 219   2020.2( ISSN:0001-6543 )

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  • Dementia risk by combinations of metabolic diseases and body mass index: Japan Gerontological Evaluation Study Cohort Study Reviewed Major achievement

    Yokomichi H, Kondo K, Nagamine Y, Yamagata Z, Kondo N

    Journal of Diabetes Investigation   11 ( 1 )   206 - 215   2020.1( ISSN:2040-1116  eISSN:2040-1124 )

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    Aims/Introduction: To compare the dementia risk associated with pre-existing diabetes, hypertension, dyslipidemia, obesity (body mass index [BMI] ≥25 kg/m ) and underweight (BMI <18.5 kg/m ) among older adults. We also explored the dementia risk associated with combinations of metabolic diseases and BMI. Materials and Methods: We used data from the Japan Gerontological Evaluation Study. Participants completed a health checkup in 2010 and were followed for 5.8 years on average. Dementia was measured by municipal long-term care insurance registration. Diabetes, hypertension, dyslipidemia, obesity and underweight were diagnosed by medication use or health examination results. We calculated the incidence of dementia and adjusted hazard ratios (HRs). Results: Among 3,696 participating older adults, 338 developed dementia. Adjusted HRs (95% confidence intervals) in men and women (reference: those without corresponding disease of normal weight) were as follows: 2.22 (1.26–3.90) and 2.00 (1.07–3.74) for diabetes; 0.56 (0.29–1.10) and 1.05 (0.64–1.71) for hypertension; 1.30 (0.87–1.94) and 0.73 (0.49–1.08) for dyslipidemia; 0.73 (0.42–1.28) and 0.82 (0.49–1.37) for BMI of 25–29.9 kg/m ; and 1.04 (0.51–2.10) and 1.72 (1.05–2.81) for underweight. Dementia risk was significantly higher in underweight men with dyslipidemia (HR 4.15, 95% CI 1.79–9.63) compared with normal-weight men without dyslipidemia, and in underweight women with hypertension (HR 3.79, 1.55–9.28) compared with normal-weight women without hypertension. Dementia incidence was highest among underweight older adults with hypertension followed by dyslipidemia. Conclusions: Among Japanese older adults, underweight and prevalent diabetes are risk factors for developing dementia. Lower BMI is also associated with a higher incidence of dementia. 2 2 2

    File: J Diabetes Investig 2020 Yokomichi H et al. Dementia risk of underweight in older people JAGES Cohort.pdf

    DOI: 10.1111/jdi.13103

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  • 糖尿病性腎症患者におけるBMIと死亡率の関係:バイオバンク・ジャパンコホート Major achievement

    横道洋司, 小島令嗣, 堀内清華, 大岡忠生, 山縣然太朗, 山縣然太朗

    日本公衆衛生学会総会抄録集   79th   2020( ISSN:1347-8060 )

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  • 機械学習技術を用いて健康診断結果から糖尿病発症率を予測する方法の検討

    大岡忠生, 横道洋司, 山縣然太朗

    日本疫学会学術総会講演集(Web)   30th   2020

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  • Individual and regional characteristics associated with maternal smoking during pregnancy in Japan: Healthy Parents and Children 21 Reviewed

    Ooka T, Akiyama Y, Shinohara R, Yokomichi H, Yamagata Z

    International Journal of Environmental Research and Public Health   17 ( 1 )   173   2019.12( ISSN:1660-4601 )

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    Smoking during pregnancy causes various maternal and fetal health problems. Although there are considerable differences in maternal smoking proportions between localities, only a few studies have investigated the effects of regional characteristics on maternal smoking behavior. This study aimed to clarify the association between maternal smoking during pregnancy and individual and regional characteristics. We used data from a large nationwide birth cohort study in Japan that consisted of information on 20,267 women with children aged 3-4 months. The multilevel regression model was used to examine the association between smoking behavior during pregnancy and individual and regional characteristics. On multilevel analysis, late birth order, young age of the mother at birth, low birth weight, low economic status, husband's smoking during pregnancy, maternal alcohol consumption during pregnancy, absence of a pregnancy counselor, and lack of participation in local events for childrearing were significantly associated with maternal smoking behavior during pregnancy at the individual level. Meanwhile, a high unemployment rate and a high number of nurseries were significantly associated with maternal smoking behavior during pregnancy at the regional level. In conclusion, we showed the relation between maternal smoking during pregnancy and the individual- and regional-level characteristics.

    File: Int J Environ Res Public Health 2020 Ooka T et al. Individual and regional characteristics and maternal smoking.pdf

    DOI: 10.3390/ijerph17010173

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    Other Link: https://www.mdpi.com/1660-4601/17/1/173

  • Association between hepatocellular carcinoma mortality and medical policy—Joinpoint regression Reviewed Major achievement

    Yokomichi H, Iwasa K, Uchida H, Ono C, Yoneyama A, Takakura E, Yamagata Z

    Journal of Health and Welfare Statistics   66 ( 10 )   21 - 28   2019.10

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    Other Link: https://www.hws-kyokai.or.jp/paper/120-2016-02-15-03-07-32/2352-201910-3.html

  • Predictors of poor Global Alignment and Proportion Score after surgery for adult spinal deformity Reviewed

    Ohba, T, Ebata S, Oba H, Koyama K, Yokomichi H, Haro H

    Spine   44 ( 19 )   e1136 - e1143   2019.10( ISSN:0362-2436 )

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    DOI: 10.1097/BRS.0000000000003086

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    Other Link: https://journals.lww.com/spinejournal/Abstract/publishahead/Predictors_of_Poor_Global_Alignment_and_Proportion.94618.aspx

  • 大麦β-グルカン摂取量と腸内細菌叢の関連 横断研究

    松岡 翼, 村上 晴香, 横道 洋司, 宮地 元彦, 國澤 純, 山縣 然太朗

    日本公衆衛生学会総会抄録集   78回   549 - 549   2019.10( ISSN:1347-8060 )

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  • Dementia incidence from combinations of diabetes, hypertension, dyslipidaemia and body mass index: Japan Gerontological Evaluation Study Reviewed Major achievement

    H. Yokomichi, K. Kondo, Y. Nagamine, Z. Yamagata, M. Mochizuki, N. Kondo

    DIABETOLOGIA   1 ( Suppl1 )   S283   2019.9( ISSN:0012-186X )

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    Other Link: https://link.springer.com/content/pdf/10.1007%2Fs00125-019-4946-6.pdf

  • Increase trend in proportions of overweight and obesity in Japanese paediatric patients with type 1 diabetes Reviewed

    M. Mochizuki, M. Anzo, K. Matsuo, S. Soneda, Y. Ito, I. Musha, K. Kobayashi, H. Yokomichi, N. Matsuura, N. Sasaki, S. Sugihara, T. Kikuchi, S. Amemiya, the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes

    DIABETOLOGIA   1 ( Suppl1 )   S62   2019.9( ISSN:0012-186X )

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    Other Link: https://link.springer.com/content/pdf/10.1007%2Fs00125-019-4946-6.pdf

  • Descriptive epidemiology of paediatric hospitalisation for severe complications of influenza virus infection using Japanese administrative data Invited Reviewed Major achievement

    Hiroshi Yokomichi, Mie Mochizuki, Reiji Kojima, Zentaro Yamagata

    Precision Medicine   2 ( 9 )   82 - 86   2019.8

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    Other Link: http://hokuryukan-ns.co.jp/cms/book_category/x11/

  • Epidemiological analysis of achalasia in Japan using a large-scale claims database Reviewed Major achievement

    Sato H, Yokomichi H, Takahashi K, Tominaga K, Mizusawa T, Kimura N, Kawata Y, Terai S

    Journal of Gastroenterology   54 ( 7 )   621 - 627   2019.7( ISSN:0944-1174 )

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    BACKGROUND: Achalasia is a well-known esophageal motility disorder, but epidemiological studies in Japan are lacking. We investigated the incidence and period prevalence of achalasia in Japan, including the rate of coexistence of esophageal carcinoma, and evaluated treatment trends. METHODS: To estimate the nationwide number of patients with achalasia, a large-scale insurance claims database from 2005 to 2017 were used for our analyses. Patients with achalasia and coexistence of esophageal carcinoma were identified based on the diagnosis code registered. Interventional treatment was also evaluated. RESULTS: Of the total 5,493,650 populations, 385 were diagnosed with primary achalasia. The incidence was calculated as 0.81-1.37 per 100,000 person-years (male-to-female ratio was almost 1; mean age at diagnosis was 43.3 ± 14.4 years). The period prevalence was 7.0 per 100,000 persons. There were statistically significant trends of increase in the incidence and period prevalence over age groups (all p values < 0.0001). Four men with achalasia developed esophageal carcinoma, and the incidence of esophageal carcinoma with achalasia was estimated as 0.25 per 100 person-years. With regard to intervention, esophageal dilation was performed as a first treatment in 64.7% of patients, with repeat intervention required in 56.9% of these. The proportion of patients treated using peroral endoscopic myotomy (POEM) increased annually to 41.1% in 2017. CONCLUSIONS: In Japan, the incidence and period prevalence of achalasia is comparable to that in other countries. The absolute risk of esophageal carcinoma is rather low. Esophageal dilation has been the mainstay of achalasia treatment, and the role of POEM has increased annually.

    File: J Gastroenterol 2019 Sato H achalasia prevalence in Japan.pdf

    DOI: 10.1007/s00535-018-01544-8

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  • Epidemiology of hospitalisation for severe complications of influenza virus infection using Japanese administrative data (reused) Invited Reviewed Major achievement

    Hiroshi Yokomichi, Mie Mochizuki, Zentaro Yamagata

    Caring Communities   21 ( 6 )   66 - 70   2019.6( ISSN:13450123 )

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    Other Link: http://hokuryukan-ns.co.jp/cms/books/bio-clinica-2019%E5%B9%B4-2%E6%9C%88%E5%8F%B7/

  • Soluble CLEC-2 is generated independently of ADAM10 and is increased in plasma in acute coronary syndrome: Comparison with soluble GPVI Reviewed

    Inoue O, Osada M, Nakamura J and Kazama F (co-first authors), Shirai T, Tsukiji N, Sasaki T, Yokomichi H, Dohi T, Kaneko M, Kurano M, Oosawa M, Tamura S, Satoh K, Takano K, Miyauchi K, Daida H, Yatomi Y, Ozaki Y, Suzuki-Inoue K

    International Journal of Hematology   110 ( 3 )   285 - 294   2019.6( ISSN:0925-5710 )

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    Soluble forms of platelet membrane proteins are released upon platelet activation. We previously reported that soluble C-type lectin-like receptor 2 (sCLEC-2) is released as a shed fragment (Shed CLEC-2) or as a whole molecule associated with platelet microparticles (MP-CLEC-2). In contrast, soluble glycoprotein VI (sGPVI) is released as a shed fragment (Shed GPVI), but not as a microparticle-associated form (MP-GPVI). However, mechanism of sCLEC-2 generation or plasma sCLEC-2 has not been fully elucidated. Experiments using metalloproteinase inhibitors/stimulators revealed that ADAM10/17 induce GPVI shedding, but not CLEC-2 shedding, and that shed CLEC-2 was partially generated by MMP-2. Although MP-GPVI was not generated, it was generated in the presence of the ADAM10 inhibitor. Moreover, antibodies against the cytoplasmic or extracellular domain of GPVI revealed the presence of the GPVI cytoplasmic domain, but not the extracellular domain, in the microparticles. These findings suggest that most of the GPVI on microparticles are induced to shed by ADAM10; MP-GPVI is thus undetected. Plasma sCLEC-2 level was 1/32 of plasma sGPVI level in normal subjects, but both soluble proteins significantly increased in plasma of patients with acute coronary syndrome. Thus, sCLEC-2 and sGPVI are released by different mechanisms and released in vivo upon platelet activation.

    File: Int J Hematol 2019 Inoue O et al. Soluble CKEC-2 in acute coronary syndrom.pdf

    DOI: 10.1007/s12185-019-02680-4

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  • 福祉の現場から レセプトデータによる重症インフルエンザに関する疫学研究. Invited

    横道 洋司, 望月 美恵, 山縣 然太朗

    地域ケアリング   21 ( 6 )   67 - 71   2019.5

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  • Incidence of hospitalisation for severe complications of influenza virus infection in Japanese patients between 2012 and 2016: a cross-sectional study using routinely collected administrative data Reviewed Major achievement

    Yokomichi H, Mochizuki M, Lee JJ, Kojima R, Yokoyama T, Yamagata Z

    BMJ Open   9 ( 1 )   e024687   2019.1( ISSN:2044-6055 )

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    OBJECTIVE: To calculate the incidence of hospitalisation due to acute respiratory failure, pneumonia, acute respiratory distress syndrome (ARDS), febrile seizures and encephalitis/encephalopathy among influenza-positive patients in Japan, where point-of-care tests are routinely used to diagnose influenza. DESIGN: A cross-sectional study using routinely collected data. SETTING: Japanese clinics and hospitals between 2012 and 2016. PARTICIPANTS: Japanese patients aged 0-74 years diagnosed with influenza by a rapid test in employment-related health insurance records. PRIMARY OUTCOME MEASURES: Incidence of hospitalisation per 100 000 influenza-positive episodes. RESULTS: We included over 16 million influenza-positive episodes, 1.0% of whom were hospitalised. Of these, 3361 were acute respiratory failure, 27 253 pneumonia, 18 ARDS, 2603 febrile seizure and 159 encephalitis/encephalopathy. The percentage of hospitalisations by age was 2.96% of patients aged 0-1 years, 0.77% aged 2-5, 0.51% aged 6-12, 0.78% aged 13-18, 1.36% aged 19-44, 1.19% aged 45-64, and 2.21% aged 65-74. The incidence of hospitalisations from these five complications combined was highest in influenza-positive patients aged 0-1 years (943 per 100 000) compared with 307 in those aged 2-5 years and 271 in those aged 65-74 years. For pneumonia, the incidence was highest for influenza-positive patients aged 0-5 years and 65 years or more. There were statistically significant decreasing trends over the years in the incidence of all-cause hospitalisations, pneumonia and febrile seizures. CONCLUSIONS: Japanese administrative data revealed that 1.0% of influenza-positive patients aged under 75 years were hospitalised. Male patients had a higher incidence of pulmonary complications and febrile seizures. Children aged 0-5 years and adults aged 65-74 years were at high risk of being admitted to hospital for pneumonia.

    File: BMJ Open 2019 Yokomichi H et al. Incidence of hospitalisation with influenza in Japan.pdf

    DOI: 10.1136/bmjopen-2018-024687

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  • Epidemiology of severe influenza infection using administrative data Invited Reviewed Major achievement

    Hiroshi Yokomichi, Mie Mochizuki, Zentaro Yamagata

    BIO Clinica   34 ( 2 )   54 - 59   2019.1( ISSN:0919-8237 )

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    Other Link: http://hokuryukan-ns.co.jp/cms/books/bio-clinica-2019%E5%B9%B4-2%E6%9C%88%E5%8F%B7/

  • Early excessive growth with distinct seasonality in preschool obesity Reviewed

    Isojima T, Kato N, Yokoya S, Ono A, Tanaka T, Yokomichi H, Yamagata Z, Tanaka S, Matsubara H, Ishikuro M, Kikuya M, Chida S, Hosoya M, Kuriyama S, Kure S

    ARCHIVES OF DISEASE IN CHILDHOOD   104 ( 1 )   53 - 57   2019.1( ISSN:0003-9888 )

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    Objectives: Healthy-weight children tend to gain weight during winter but lose weight during summer. However, overweight elementary school children have shown accelerated summertime weight gain. Whether this seasonal growth variation occurs during preschool period is of substantial interest. Methods: Data were derived from a nationwide retrospective cohort of nursery school children. Eight consecutive sets of longitudinal measurements on height and weight were obtained from 15 259 preschool children. Thereafter, growth in height, weight and body mass index (BMI) over a period of 6 months was calculated. Summertime growth was defined as that from April to October, whereas wintertime growth was defined as that from October to April of the following year. Longitudinal growth seasonality was analysed by classifying children according to their BMI status at the age of elementary school entry. Results: Accelerated summertime weight and BMI gain were observed among children with obesity. This distinctive growth seasonality was detected from around age 2. Children having this growth seasonality at approximately 2 years of age tended to be obese at the age of elementary school entry (OR: 3.7
    95% CI: 2.9 to 4.6
    p&lt
    0.0001). In height gain, obese children were growing apparently faster than those in the other groups at all ages. Conclusion: Early excessive growth with distinct seasonality was observed in preschool obese children. These findings suggest that individuals involved in child healthcare should pay closer attention to early excessive growth with distinct seasonality in preschool obesity.

    DOI: 10.1136/archdischild-2018-314862

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  • Risk factors for perforation during endoscopic retrograde cholangiopancreatography in post-reconstruction intestinal tract Reviewed

    Takano S, Fukasawa M, Shindo H, Takahashi E, Hirose S, Fukasawa Y ,Kawakami S, Hayakawa H, Yokomichi H, Kadokura M, Sato T, Enomoto N

    World Journal of Clinical Cases   7 ( 1 )   10 - 18   2019.1( ISSN:2307-8960 )

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    File: World J Clin Case 2019 Takano S et al. perforation risk factors of ERCP after intestinal reconstruction.pdf

    DOI: 10.12998/wjcc.v7.i1.3091

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  • Problematic Internet use and its associations with health-related symptoms and lifestyle habits among rural Japanese adolescents Reviewed

    Kojima R, Sato M, Akiyama Y, Shinohara R, Mizorogi S, Suzuki K, Yokomichi H, Yamagata Z

    Psychiatry and Clinical Neurosciences   73   20 - 26   2019.1( ISSN:1323-1316 )

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    File: Psychiatr Clin Neurosci 2019 Kojima R et al Intenet addiction and related factors.pdf

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  • 地域保健活動を基盤とした出生コホート研究の意義-甲州プロジェクト30年-

    山縣然太朗, 山縣然太朗, 横道洋司, 三宅邦夫, 佐藤美理, 秋山有佳, 小島令嗣, 大岡忠生, 小田和早苗

    日本疫学会学術総会講演集(Web)   29th   2019

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  • 妊娠前の母親の炭水化物摂取状況と児の低出生体重との関連-甲州市母子保健縦断調査より-

    秋山有佳, 小島令嗣, 佐藤美理, 大岡忠生, 横道洋司, 山縣然太朗, 山縣然太朗

    日本疫学会学術総会講演集(Web)   29th   2019

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  • Results of survey on passive smoking of secondary and high school students in Yamanashi Prefecture, Japan Reviewed

    Keiichiro Iwasa, Mizuho Watanabe, Hiroshi Yokomichi, Zentaro Yamagata

        65 ( 10 )   30 - 35   2018.10

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  • 山梨県甲州市における妊婦の妊娠前の食事内容の変化 甲州プロジェクト30年の記録

    秋山 有佳, 大岡 忠生, 小島 令嗣, 佐藤 美理, 大西 一成, 横道 洋司, 山縣 然太朗

    日本公衆衛生学会総会抄録集   77回   381 - 381   2018.10( ISSN:1347-8060 )

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  • 甲州プロジェクト30年にみる地域の保健活動を基にした出生コホート研究の意義

    山縣 然太朗, 横道 洋司, 大西 一成, 佐藤 美理, 小島 令嗣, 秋山 有佳, 大岡 忠生

    日本公衆衛生学会総会抄録集   77回   225 - 225   2018.10( ISSN:1347-8060 )

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  • 1歳6ヵ月児の睡眠と母親の就労の関連について 甲州プロジェクト30年の記録

    大岡 忠生, 秋山 有佳, 小島 令嗣, 佐藤 美理, 大西 一成, 横道 洋司, 山縣 然太朗

    日本公衆衛生学会総会抄録集   77回   381 - 381   2018.10( ISSN:1347-8060 )

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  • 5歳児健診30年間の推移 甲州プロジェクトより

    小島 令嗣, 秋山 有佳, 佐藤 美理, 大岡 忠生, 大西 一成, 横道 洋司, 山縣 然太朗

    日本公衆衛生学会総会抄録集   77回   381 - 381   2018.10( ISSN:1347-8060 )

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  • Impact of the Great East Japan Earthquake on body mass index, weight and height of infants and toddlers: an infant survey Reviewed Major achievement

    Yokomichi H, Matsubara H, Ishikuro M, Kikuya M, Isojima T, Yokoya S, Tanaka T, Kato N, Chida S, Ono A, Hosoya M, Tanaka S, Kuriyama S, Kure S, Yamagata Z

    JOURNAL OF EPIDEMIOLOGY   28 ( 5 )   237 - 244   2018.5( ISSN:0917-5040 )

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    BACKGROUND: The body mass index (BMI) of preschool children from 4 years of age through primary school has increased since the Great East Japan Earthquake, but that of children aged under 3 years has not been studied. This study evaluated how the anthropometrics of younger children changed following the earthquake. METHODS: Height and weight data of children living in northeast Japan were collected from 3-, 6-, 18-, and 42-month child health examinations. We compared the changes in BMI, weight, and height among infants affected by the earthquake between their 3- and 6-month health examinations, toddlers affected at 21-30 months of age (affected groups), and children who experienced the earthquake after their 42-month child health examination (unaffected group). A multilevel model was used to calculate the BMI at corresponding ages and to adjust for the actual age at the 3-month health examination, health examination interval, and gestational age. RESULTS: We recruited 8,479 boys and 8,218 girls living in Fukushima, Miyagi, and Iwate Prefectures. In the infants affected between their 3- and 6-month health examinations in Fukushima, the change in BMI at 42 months of age was greater than among the unaffected children. In the toddlers affected at 21-30 months of age in Fukushima, the change in BMI was greater, but changes in weight and height were less. CONCLUSIONS: Affected infants and toddlers in Fukushima suggested some growth disturbances and early adiposity rebound, which can cause obesity. The future growth of children affected by disasters should be followed carefully.

    File: J Epidemiol 2018 Yokomichi H et al. Great east Japan earthquake and infant growth.pdf

    DOI: 10.2188/jea.JE20170006

    DOI: 10.2188/jea.JE2017000610.2188/jea.JE20170006

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  • Relationship between socioeconomic status and the prevalence of underweight, overweight or obesity in a general Japanese population: NIPPON DATA2010 Reviewed

    Tomiyo Nakamura, Yasuyuki Nakamura, Shigeyuki Saitoh, Tomonori Okamura, Masahiko Yanagita, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Hiroshi Yokomichi, Nobuo Nishi, Nagako Okuda, Aya Kadota, Takayoshi Ohkubo, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    JOURNAL OF EPIDEMIOLOGY   Suppl 3   S10 - S16   2018.3( ISSN:0917-5040 )

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    BACKGROUND: Socioeconomic status (SES) imbalances in developed and developing countries may result in individuals being overweight and obese. However, few studies have investigated this issue in Japan. We herein examined the relationship between SES and being underweight, overweight or obese according to sex and age groups (20-64 or ≥65 years) in Japan. METHODS: In 2010, we established a cohort of participants in the National Health and Nutrition Survey of Japan. We divided 2,491 participants (1,081 men and 1,410 women) according to the WHO definitions of underweight, overweight or obesity and performed multinomial logistic analyses using BMI <18.5 kg/m2 (underweight), BMI 25.0-29.9 kg/m2 (overweight), and BMI ≥30.0 kg/m2 (obese) versus BMI 18.5-24.9 kg/m2 (normal) as the outcome, with SES groups as the main explanatory variables. RESULTS: In adult men, a lower education level relative to a higher education level was inversely associated with obesity after adjustments for other SESs (odds ratio [OR] 0.41; 95% confidence interval [CI], 0.18-0.96). However, in adult women, lower education level was positively associated with being overweight and obese (OR 1.67; 95% CI, 1.07-2.49 for overweight and OR 2.66; 95% CI, 1.01-7.01 for obese). In adult women, a lower household income was positively associated with being overweight and obese (obese: OR 4.84; 95% CI, 1.36-17.18 for those with a household income <2 million JPY relative to those with ≥6 million JPY). CONCLUSIONS: In adult women, a lower education level and lower household income were positively associated with being overweight or obese. In contrast, in adult men, a lower education level was inversely associated with obesity. Gender and age differences in SESs affect the prevalence of being overweight or obese.

    File: J Epidemiol 2018 Nakamura T et al. SES and underweight and obesity in Japanese population NIPPON DATA.pdf

    DOI: 10.2188/jea.JE20170249

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  • インフルエンザ罹患時の重症化率 大規模レセプトデータの分析から

    横道 洋司, 望月 美恵, 小島 令嗣, 山縣 然太朗

    日本小児科学会雑誌   122 ( 2 )   331 - 331   2018.2( ISSN:0001-6543 )

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  • Earlier BMI rebound and lower pre-rebound BMI as risk of obesity among Japanese preschool children Reviewed

    N Kato, T Isojima, S Yokoya, T Tanaka, A Ono, H Yokomichi, Z Yamagata, S Tanaka, H Matsubara, M Ishikuro, M Kikuya, S Chida, M Hosoya, S Kuriyama & S Kure

    INTERNATIONAL JOURNAL OF OBESITY   42 ( 1 )   52 - 58   2018.1( ISSN:0307-0565 )

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    Objectives:Longitudinal growth data of children were analyzed to clarify the relationship between the timing of body mass index (BMI) rebound and obesity risk in later ages.Subjects/Methods:Of 54 558 children born between April 2004 and March 2005 and longitudinally measured in April and October every year in the preschool period, 15 255 children were analyzed wherein no longitudinal measurement is missing after 1 year of age. BMI rebound age was determined as the age with smallest BMI value across longitudinal individual data after 1 year of age. Rebound age was compared between overweight and non-overweight groups. The subjects were divided into groups based on the timing of rebound. The sex- A nd age-adjusted mean of the BMI, height and weight s.d. scores for age group, along with 6 months weight and height gain, were compared among groups using analysis of covariance.Results:Among those who were overweight at 66-71 months of age, BMI rebound age obtained at approximately 3 years of age was compared with the non-overweight group, whose BMI rebound age was utmost 66 months or later (P&lt
    0.001). The comparison among BMI age group showed that earlier BMI rebound results in larger BMI (P&lt
    0.001) and larger weight and height gain after the rebound (P&lt
    0.001). Among the group with BMI rebound earlier than 30 months of age, low BMI was observed (P&lt
    0.001). Slight elevation of height and weight gain was observed before the BMI rebound among groups with rebound age earlier than 60 months of age (P&lt
    0.001).Conclusion:Earlier BMI rebound timing with pre-rebound low BMI leads to greater childhood obesity risk
    hence, early detection and prevention is necessary for such cases.

    DOI: 10.1038/ijo.2017.242

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  • HbA1c monitoring interval in patients on treatment for stable type 2 diabetes. A ten-year retrospective, open cohort study Reviewed

    Sachiko Ohde, Gautam A. Deshpande, Hiroshi Yokomichi, Osamu Takahashi, Tsuguya Fukui, Zentaro Yamagata

    Diabetes Research and Clinical Practice   135   166 - 171   2018.1( ISSN:0168-8227 )

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    [Aims] This study aims to suggest an informative interval for HbA1c in DM patients with stable glycemic control, based on test characteristics of the HbA1C assay using the signal-to-noise ratio method. [Methods] This was a retrospective, open cohort study. Data were collected between January 2005 to December 2014 at a tertiary-level community hospital in Japan. All adult patients aged under 75 years, with stable glycemic control on a first pharmaceutical regimen for Type II diabetes, and at least two HbA1c measurements after they achieved glycemic stability, were included in the analysis. We defined stable glycemic control as HbA1c <7.0% (52 mmol/mol) and requiring no change in the medication regimen after three consecutive measurements. We adapted a signal-to-noise method for distinguishing true change from measurement error by constructing a linear random effects model to calculate signal and noise for HbA1c. The screening interval for HbA1c was defined as informative when the signal-to-noise ratio exceeded 1. [Results] Among 1066 adults with diabetes, 639 patients (18.5%) were identified as achieving stable glycemic control (511 male (67.3%)), with a mean HbA1c (SD) of 6.4 (0.4)% (46 mmol/mol). Patients with stable glycemic control increase their HbA1c 0.27% (3 mmol/mol) every year while HbA1c has 0.32% (3.5 mmol/mol) noise, as testing characteristics. Signal exceeds noise after 1.2 years (95%CI: 0.9-1.6). [Conclusion] Once patients achieve stable glycemic control at their HbA1c goal, an informative interval for HbA1c monitoring is once every year. Current guidelines, which suggest testing every six months, may contribute to substantial over-testing.

    File: Diabetes Res Clin Pract 2018 Ohde S et al. Optimal HbA1c monitoring interval in type 2 diabetes.pdf

    DOI: 10.1016/j.diabres.2017.11.013

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  • Impact of the great east Japan earthquake on the body mass index of milk-fed infants and toddlers: a nationwide infant survey Reviewed Major achievement

    Yokomichi H, Matsubara H, Ishikuro M, Kikuya M, Isojima G, Yokoya S, Kato N, Tanaka T, Ono A, Hosoya M, Chida S, Tanaka S, Kuriyama S, Kure S, Yamagata Z

    International Journal of Pediatric Endocrinology   Suppl1   113 - 114   2017.12( ISSN:1687-9856 )

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    The data indicate that immediately aftermath of the earthquake, the growth of the affected suckling infants were slightly disturbed. The affected suckling infants in Fukushima also represent increased BMI at the age of 42 months and may have potential to show early adiposity rebound. The results highlight the need of medical follow-up to the infants in Fukushima.

    Other Link: https://ijpeonline.biomedcentral.com/articles/10.1186/s13633-017-0054-x

  • Growth seasonality during preschool childhood in nursery school children Reviewed

    Isojima G, Kato N, Yokoya S, Tanaka T, Ono A, Yokomichi H, Yamagata Z, Tanaka S, Matsubara H, Ishikuro M, Kikuya M, Chida S, Hosoya M, Kuriyama S, Kure S

    International Journal of Pediatric Endocrinology   Suppl1   32 - 32   2017.12( ISSN:1687-9856 )

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    Seasonal growth variation in weight and BMI was detected in relatively overweight preschool children during infancy. These findings suggested that we should be careful of summer time weight gain even in infancy for preventing the future obesity.

    Other Link: https://ijpeonline.biomedcentral.com/articles/10.1186/s13633-017-0054-x

  • Metabolomics Approach to Male Lower Urinary Tract Symptoms: Identification of Possible Biomarkers and Potential Targets for New Treatments Reviewed

    Takahiko Mitsui, Satoru Kira, Tatsuya Ihara, Norifumi Sawada, Hiroshi Nakagomi, Tatsuya Miyamoto, Hiroshi Shimura, Hiroshi Yokomichi, Masayuki Takeda

    JOURNAL OF UROLOGY   199 ( 5 )   1312 - 1318   2017.11( ISSN:0022-5347 )

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    Purpose: We identified metabolites using a metabolomics approach and investigated the association between these metabolites and lower urinary tract symptoms. Materials and Methods: We used a 24-hour bladder diary and I-PSS (International Prostate Symptom Score) to assess micturition behavior and lower urinary tract symptoms in 58 male patients without apparent neurological disease. Lower urinary tract symptoms were defined as a total I-PSS score of 8 or greater. Patients with a score of 7 or less were placed in the control group. A comprehensive study of plasma metabolites was also performed by capillary electrophoresis time-of-flight mass spectrometry. Metabolites were compared between the lower urinary tract symptoms and control groups using the Mann-Whitney U test. Biomarkers of male lower urinary tract symptoms from the metabolites were analyzed using multivariable logistic regression analysis to determine the OR. Results: Of the 58 men 32 were in the lower urinary tract symptoms group and the remaining 26 were in the control group. The 24-hour bladder diary showed that nocturnal urine volume, 24-hour micturition frequency, nocturnal micturition frequency and the nocturia index were significantly higher in the lower urinary tract symptoms group. Metabolomics analysis identified 60 metabolites from patient plasma. Multivariate analysis revealed that increased glutamate and decreased arginine, asparagine and inosine monophosphate were significantly associated with lower urinary tract symptoms in males. Decreases in citrulline and glutamine could also be associated with male lower urinary tract symptoms. Conclusions: Male lower urinary tract symptoms may develop due to abnormal metabolic processes in some pathways. Potential new treatments for lower urinary tract symptoms can be developed by identifying changes in the amino acid profiles.

    File: J Urology 2018 Mitsui et al.pdf

    DOI: 10.1016/j.juro.2017.11.070

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  • Alterations in physique among young children after the great east Japan earthquake: results from a nationwide survey Reviewed

    Kikuya M,Matubara H,Ishikuro M,Sato Y,Obara T,Metoki H,Isojima T,Yokoya S,Kato N,Tanaka T,Chida S,Ono A,Hosoya M,Yokomichi H,Yamagata Z,Tanaka S,Kure S,Kuriyama S

    JOURNAL OF EPIDEMIOLOGY   27 ( 10 )   462 - 468   2017.10( ISSN:0917-5040 )

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    Background: Data for earthquake-related alterations in physique among young children in developed countries is lacking. The Great East Japan Earthquake caused severe damage in Iwate, Miyagi, and Fukushima Prefectures in northeastern Japan.
    Methods: We retrospectively obtained anthropometric measurements in nursery school from 40,046 (cohort 1, historical control) and 53,492 (cohort 2) children aged 3.5-4.5 years without overweight in October 2008, and in October 2010, respectively. At the time of the earthquake in March, 2011, children in cohort 1 had already graduated from nursery school; however, children in cohort 2 were still enrolled in nursery school at this time. We compared the onset of overweight at 1 year after the baseline between children enrolled in their school located in one of the three target prefectures versus those in other prefectures using a logistic regression model, with adjustment for sex, age, history of disease, and obesity index at baseline. Overweight was defined as an obesity index of &gt; +15%, which was calculated as (weight minus sex-and height-specific standard weight)/sex-and height-specific standard weight.
    Results: The odds ratio (OR) for the onset of overweight in the three target prefectures was significant in cohort 2 (OR 1.25; 95% confidence interval [CI], 1.01-1.55) but not in cohort 1. When the two cohort were pooled (n = 93,538), the OR of the interaction term for school location x cohort was significant (OR 1.56; 95% CI, 1.09-2.23).
    Conclusions: Incident overweight in young children was significantly more common in the three prefectures affected by the Great East Japan Earthquake than in other prefectures after the disaster. (C) 2017 The Authors. Publishing services by Elsevier B. V. on behalf of The Japan Epidemiological Association.

    File: J Epidemiol 2017 Kikuya M et al. Young child body alteration after the Greas East Japan Earthquake.pdf

    DOI: 10.1016/j.je.2016.09.012

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  • The ratio of glycated albumin to HbA (1c) as a haemoglobin glycation index with intra-familial correlations Reviewed

    S Amemiya, M Mochizuki, I Musha, T Kikuchi, H Yokomichi, S Sugihara, T Hoshino

    DIABETOLOGIA   60   S509 - S510   2017.9( ISSN:0012-186X )

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  • Improvement in glycemic control through changes in insulin regimens: findings from a Japanese cohort of children and adolescents with type 1 diabetes Reviewed

    Mie MOCHIZUKI,Toru KIKUCHI,Tatsuhiko URAKAMI,Nobuyuki KIKUCHI,Tomoyuki KAWAMURA,Hiroshi YOKOMICHI,Tadao HOSHINO,Nobuo MATSUURA,Nozomu SASAKI,Shigetaka SUHIGARA,Shin AMEMIYA, on behalf of The Japanese Study Group of Insulin Therapy for Childhood Adolescent Diabetes

    Pediatric Diabetes   18 ( 6 )   435 - 442   2017.9( ISSN:1399-543X  eISSN:1399-5448 )

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    Objective: Although insulin analogs have dramatically changed diabetes treatment, scarce evidence is available on those effects. We aimed to explore whether glycemic control had improved, the use of insulin analogs had been increased, and hypoglycemic events had decreased over time in Japanese pediatric patients with type 1 diabetes (T1D).
    Methods: Glycated hemoglobin A1c (HbA1c) values, proportion of insulin regimens, incidence of severe hypoglycemic events, and pubertal increase in HbA1c were compared in three cohorts of childhood-onset Japanese T1D patients (567 subjects in the 1995 cohort, 754 subjects in the 2000 cohort, and 806 subjects in the 2008 cohort).
    Results: Mean HbA1c values tended to decrease [78.5 mmol/mol (9.33%) in the 1995 cohort, 68.2 mmol/mol (8.39%) in the 2000 cohort, and 61.2 mmol/mol (7.75%) in the 2008 cohort; P &lt; .0001]. The proportion of patients who received basal-bolus treatment tended to increase with statistical significance, as did the proportion on insulin analogs. The incidence of severe hypoglycemic events (events/100 patients/y) had decreased (19.1 in the 2000 cohort and 8.7 in the 2008 cohort; P = .02). The pubertal increase in HbA1c tended to decrease [males, 12.0 mmol/mol (1.10%) in 1995, 9.4 mmol/mol (0.85%) in 2008, and 9.4 mmol/mol (0.86%) in 2008; P = .55; females, 14.0 mmol/mol (1.28%) in 1995, 10.3 mmol/mol (0.94%) in 2000, and 4.2 mmol/mol (0.38%) in 2008; P = .0003].
    Conclusions: Glycemic control and incidence of severe hypoglycemic events were chronologically improved, especially in female adolescents.

    File: Pediatr Diabetes 2016 Mochizuki M et al. Secular ttend of glycaemic control improvement in type 1 diabetes.pdf

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  • Effect of text messages to improve health literacy on medication adherence in patients with type 2 diabetes mellitus: a randomized controlled pilot trial Reviewed

    Sugita H, Shinohara R, Yokomichi H, Suzuki K, Yamagata Z

    Nagoya Journal of Medical Science   79 ( 3 )   313 - 321   2017.8( ISSN:2186-3326  eISSN:0027-7622 )

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    It has been suggested that low health literacy (HL) is associated with poor medication adherence. This study aimed to examine the effect of a text message-based HL intervention to promote medication adherence, compared with text messages that only sent medication reminders, in patients with type 2 diabetes. This was a single-center, open-label, randomized (1: 1) controlled pilot study. The study period was 6 months. Intervention group was sent HL related text messages, compared to the reminder messages that were sent to the control group. The primary outcome was the difference in the change rate of scores on the Morisky Eight-Item Medication Adherence Scale (MMAS-8). Forty-one participants were randomized into the intervention (n = 21) and control (n = 20) groups and completed the 6-month follow-up. Although almost participants read and understood the information provided in the messages, no significant difference was observed between groups for the primary outcome (p = 0.78). Our results suggested that medication adherence at 6 months after discharge in patients with type 2 diabetes did not significantly change by text messages, which aimed to improve their HL levels.

    File: Nagoya J Med 2017 Sugita H et al. Text message and health literacy in type 2 diabetes. RCT.pdf

    DOI: 10.18999/nagjms.79.3.313

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  • Molecular alterations of coexisting thyroid papillary carcinoma and anaplastic carcinoma: identification of TERT mutation as an independent risk factor for transformation Reviewed

    Naoki Oishi, Tetsuo Kondo, Aya Ebina, Yukiko Sato, Junko Akaishi, Rumi Hino, Noriko Yamamoto, Kunio Mochizuki, Tadao Nakazawa, Hiroshi Yokomichi, Koichi Ito, Yuichi Ishikawa and Ryohei Katoh

    MODERN PATHOLOGY   30 ( 11 )   1527 - 1537   2017.6( ISSN:0893-3952  eISSN:1530-0285 )

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    Thyroid papillary carcinoma is the most common endocrine neoplasm and generally carries a favorable prognosis. However, a small subset of papillary carcinomas transforms into anaplastic carcinoma, an undifferentiated cancer with a dismal prognosis. Recent studies using next-generation sequencing revealed the genomic landscape of papillary carcinoma and anaplastic carcinoma. However, risk factors for anaplastic transformation in papillary carcinoma remain obscure. In the present study, we investigated molecular alterations of papillary carcinoma and anaplastic carcinoma components in 27 tumors in which anaplastic carcinoma coexisted with antecedent papillary carcinoma. We conducted direct sequencing for BRAF, TERT promoter and PIK3CA, and immunohistochemistry for p53, TTF-1 and subunits of the SWI/SNF complex (ARID1A, ARID1B, ATRX, SMARCA2, SMARCA4, SMARCB1, and PBRM1). BRAFV600E and TERT promoter mutated at the rate of 90% and 95%, respectively, and these mutational statuses were almost identical between the papillary carcinoma and anaplastic carcinoma components. PIK3CA mutation was positive in 33% of our samples with a heterogeneous mutation pattern of the papillary carcinoma and anaplastic carcinoma components. Aberrant expression of p53 and loss of TTF-1 were present in 63 and 59%, respectively, and these two alterations were confined to the anaplastic carcinoma components. There was a loss of the SWI/SNF complex in a subset of the tumors with a heterogeneous pattern of the papillary carcinoma and anaplastic carcinoma components: SMARCA4 in 4% and PBRM1 in 4%. In a multivariate comparison between the antecedent papillary carcinoma components and control papillary carcinomas without anaplastic transformation, TERT promoter mutation was independently associated with anaplastic transformation. Collectively, papillary carcinoma-derived anaplastic carcinomas are characterized by BRAF and TERT promoter mutations, and these mutations occur prior to anaplastic transformation. Alterations of PIK3CA and the SWI/SNF complex are relatively rare and temporally heterogeneous. Of note, a papillary carcinoma harboring TERT promoter mutation is at higher risk for anaplastic transformation.

    File: Modern Pathol 2017 Oishi N et al. Molecular alterations in coexisting thyroid papillary and anaplastic carcinomas.pdf

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  • Prolonged elevated body mass index of preschool children after The Great East Japan Earthquake Reviewed

    Isojima T, Yokoya S, Ono A, Kato N, Tanaka T, Yokomichi H, Yamagata Z, Tanaka S, Matsubara H, Ishikuro M, Kikukya M, Chida S, Hosoya M, Kuriyama S, Kure S

    PEDIATRICS INTERNATIONAL   59 ( 9 )   1002 - 1009   2017.6( ISSN:1328-8067  eISSN:1442-200X )

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    BackgroundThe Great East Japan Earthquake followed by tsunamis and the Fukushima Daiichi Nuclear Power Plant (NPP) accident caused catastrophic damage. The effects of the disaster on the growth of affected children are of great concern but remain unknown.
    MethodsThe subject group was derived from two Japanese nationwide retrospective cohorts (historical control and exposure groups, respectively). The exposure group experienced the disaster at 47-59months of age. We analyzed longitudinal changes in standard deviation score (SDS) for height and body mass index (BMI) using normal Japanese children's standards. Moreover, we analyzed the details of the affected children in Fukushima using Fukushima-specific growth charts established with the historical control data to clarify any indirect effect of the disaster on growth.
    ResultsAffected children in Fukushima had significantly higher BMI SDS than the historical control group (difference, 0.13; 95% CI: 0.044-0.21, P=0.0029) and the regional controls (difference, 0.14; 95% CI: 0.074-0.20, P&lt;0.0001) 1.5years after the disaster. Similar sustained increases in BMI SDS were also found with Fukushima-specific growth charts, but the phenomenon was detected only in boys. Notably, the BMI SDS of affected children who lived near the NPP had been increasing after the disaster, whereas those in distant areas had not changed. In contrast, height SDS had not changed throughout the analysis.
    ConclusionsProlonged elevated BMI SDS was detected only in affected children in Fukushima. This phenomenon may be explained by an indirect effect of the NPP accident.

    File: Pediatr Int Isojima G et al. Prolonged elevated BMI in children after the Great East Japan Earthquake.pdf

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  • Weight cycling and the subsequent onset of type 2 diabetes mellitus: 10-year cohort studies in urban and rural Japan Reviewed Major achievement

    Yokomichi H,Ohde O,Takahashi O,Mochizuki M,Takahashi A,Yoda Y,Tsuji M,Akiyama Y,Yamagata Z

    BMJ Open   7 ( 5 )   e014684   2017.5( ISSN:2044-6055 )

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    OBJECTIVE: To investigate how weight cycling (gaining and losing weight) affects the risk of diabetes. DESIGN: Cohort studies. SETTING: Primary healthcare in urban and rural Japan. PARTICIPANTS: 20 708 urban and 9670 rural residents. PRIMARY OUTCOME MEASURES: ORs for diabetes in those with weight loss, weight loss-gain, stable weight, weight gain-loss and weight gain over 10 years. Weight gain and loss were defined as a change of more than ±4% from baseline weight. RESULTS: In the urban region, the ORs relative to the stable group for the loss-gain and gain-loss groups were 0.63 (95% CI 0.45 to 0.89) and 0.51 (95% CI 0.32 to 0.82) for men and 0.72 (95% CI 0.39 to 1.34) and 1.05 (95% CI 0.57 to 1.95) for women. In the rural region, they were 1.58 (95% CI 0.78 to 3.17) and 0.44 (95% CI 0.15 to 1.29) in men and 0.41 (95% CI 0.12 to 1.44) and 0.77 (95% CI 0.28 to 2.14) in women. The ORs for an increase in weight between 5 and 10 kg from the age of 20 years were 1.54 (95% CI 1.03 to 2.30) in men and 0.96 (95% CI 0.55 to 1.65) in women. CONCLUSIONS: In Japan, weight cycling was associated with a significant reduction in the risk of diabetes for men from urban regions. The associations were unclear for women from urban regions and both men and women from rural regions. These results differ from those in Western studies, probably because of differences in diet, insulin secretion and sensitivity and weight-consciousness.

    File: BMJ Open 2017 Yokomichi H et al. Weight cycling and type 2 diabetes onset in urban and rural Japan.pdf

    DOI: 10.1136/bmjopen-2016-014684

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  • 都道府県別精麦・雑穀の消費量と死因の関連性 - 生態学研究 - Reviewed

    松岡翼, 三尾建斗, 横道洋司, 山縣然太朗

    The Journal of Japan Mibyo System Association   17 ( Suppl )   113 - 113   2017.4

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  • 糖尿病合併症としての大血管症・腎症・神経症・網膜症発症者の死因別生存時間解析 BioBank Japan Cohort

    横道 洋司, 望月 美恵, 久保 充明, 山縣 然太朗

    糖尿病   60 ( Suppl.1 )   S - 254   2017.4( ISSN:0021-437X  eISSN:1881-588X )

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  • Disease prevalence among nursery school children after the Great East Japan earthquake Reviewed

    Mami ISHIKURO,Hiroko MATSUBARA,Masahiro KIKUYA,Taku OBARA,Yuki SATO,Hirohito METOKI,Tsuyoshi ISOJIMA,Susumu YOKOYA,Noriko KATO,Toshiaki TANAKA,Shoichi CHIDA,Atsushi ONO,Mitsuaki HOSOYA,Hiroshi YOKOMICHI,Zentaro YAMAGATA,Soichiro TANAKA,Shigeo KURE,Shinichi KURIYAMA

    BMJ Global Health   2 ( 2 )   e000127   2017.3( ISSN:2059-7908 )

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    OBJECTIVE: To investigate the relationship between personal experience of the Great East Japan Earthquake and various disease types among nursery school children. DESIGN: We conducted a nationwide survey of nursery school children born between 2 April 2006 and 1 April 2007. Nursery school teachers completed questionnaires if they agreed to join the study. Questionnaire items for children consisted of their birth year and month, sex, any history of moving into or out of the current nursery school, presence of diseases diagnosed by a physician at the age of 66-78 months and type of disaster experience. The survey was conducted from September 2012 to December 2012. SETTING: Japan, nationwide. PARTICIPANTS: A total of 60 270 nursery school children were included in the analysis, 840 of whom experienced the disaster on 11 March 2011. MAIN OUTCOME MEASURES: The health status of children 1.5 years after the disaster based on nursery school records. RESULTS: Experiencing the disaster significantly affected the prevalence of overall and individual diseases. Furthermore, there was a difference in disease prevalence between boys and girls. In boys, experiencing the tsunami (OR 2.53, 95% CI 1.22 to 5.24) and living in an evacuation centre (OR 2.92, 95% CI 1.46 to 5.83) were remarkably associated with a higher prevalence of atopic dermatitis, but these trends were not observed among girls. Instead, the home being destroyed (OR 3.50, 95% CI 2.02 to 6.07) and moving house (OR 4.19, 95% CI 2.01 to 8.71) were positively associated with a higher prevalence of asthma among girls. CONCLUSIONS: Our study indicates that experiencing the disaster may have affected the health status of nursery school children at least up to 1.5 years after the disaster. Continuous monitoring of the health status of children is necessary to develop strategic plans for child health.

    File: BMJ Glob Health 2017 Ishikuro M et al. Disease prevalence among nursery school children after the Great East Japan Earthquake.pdf

    DOI: 10.1136/bmjgh-2016-000127

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  • 東日本大震災後の保育所園児における過体重の発症 被災地の子どもの発育状況等に関する全国調査 Reviewed

    Kikuya M, Matsubara H, Ishikuro M, Sato Y, Ogura T, Metoki H, Isojima G, Yokoya S, Kato N, Tanaka T, Chida S, Ono A, Hosoya M, Yokomichi H, Yamagata Z, Tanaka S, Kre S, Kuriyama S

    Journal of Miyagi Society of Public Health   ( 49 )   15 - 15   2017.3( ISSN:0912747X )

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  • Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohort Reviewed Major achievement

    Yokomichi H,Nagai A,Hirata M,Tamakoshi A,Kamatani Y,Kiyohara Y,Matsuda K,Muto K,Ninomiya T,Kubo M,Nakamura Y,BioBank Japan Cooperative Hospital Group, Yamagata Z

    JOURNAL OF EPIDEMIOLOGY   27 ( 3S )   98 - 106   2017.3( ISSN:0917-5040 )

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    Background: The number of patients with diabetes is increasing worldwide. Macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking frequently accompany type 2 diabetes. Few data are available related to mortality of Asians with diabetes associated with these serious comorbidities. The present study aimed to quantify the excess mortality risks of type 2 diabetic patients with comorbidities.
    Methods: We analysed the available records of 30,834 Japanese patients with type 2 diabetes from the BioBank Japan Project between 2003 and 2007. Men and women were followed up for median 8.03 and 8.30 years, respectively. We applied Cox proportional hazard model and Kaplan-Meier estimates for survival curves to evaluate mortality in diabetic patients with or without macrovascular disease, chronic respiratory disease, chronic kidney disease, cancer and smoking.
    Results: Adjusted hazard ratios (HRs) for mortality were 1.39 (95% CI, 1.09-1.78) for male sex, 2.01 (95% CI, 1.78-2.26) per 10-year increment of age. Adjusted HRs of primary interest were 1.77 (95% CI, 1.42-2.22), macrovascular disease; 1.58 (95% CI, 1.08-2.31), chronic respiratory disease; 2.03 (95% CI, 1.67-2.47), chronic kidney disease; 1.16 (95% CI, 0.86-1.56), cancer; and 1.74 (95% CI, 1.30-2.31), current smoking.
    Conclusions: Diabetic patients with a past or current history of chronic kidney, macrovascular or respiratory diseases or smoking habit have exhibited the highest risk of mortality. Data were limited to those of survivors of comorbidities but we propose the need to improve comorbidities and terminate cigarette smoking for better prognosis in patients with diabetes. (C) 2017 The Authors. Publishing services by Elsevier B.V. on behalf of The Japan Epidemiological Association.

    File: J Epidemiol 2017 Yokomichi H et al. Survival of complications and commorbidities with type 2 diabetes from BioBank Japan.pdf

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  • Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities: BioBank Japan Invited Reviewed Major achievement

    Yokomichi H,Noda H,Nagai A,Hirata M,Tamakoshi A,Kamatani Y,Kiyohara Y,Matsuda K,Muto K,Ninomiya T,Kubo M,Nakamura Y,BioBank Japan Cooperative Hospital Group,Yamagata Z

    JOURNAL OF EPIDEMIOLOGY   27 ( 3S )   77 - 83   2017.3( ISSN:0917-5040 )

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    Background: Controlling serum cholesterol is critical to prevent cardiovascular disease in patients with dyslipidaemia. Guidelines emphasise the need to select treatment for dyslipidaemia based on specific patient profiles; however, there is little information about the serum cholesterol levels of patients in each profile in Japan. Therefore, we aimed to describe the serum cholesterol levels and prevalence of uncontrolled cases in Japanese patients with dyslipidaemia.
    Methods: We included data for patients with dyslipidaemia between 2003 and 2007 from the BioBank Japan Project (66 hospitals). Then, we reported their serum cholesterol levels by age, body mass index, glycaemic control (glycated haemoglobin A1c), blood pressure, smoking, drinking, comorbidity and medication profiles.
    Results: We included 22,189 male and 21,545 female patients. The mean serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and non-HDL-C levels in males were 117.4 mg/dL, 51.0 mg/dL, 187.6 mg/dL and 153.6 mg/dL, respectively; the corresponding levels in females were 129.5 mg/dL, 60.5 mg/dL, 144.9 mg/dL and 157.9 mg/dL, respectively. In both males and females, the LDL-C levels were the highest in the following profiles: age 19-44 years, body mass index 18.5-22 kg/m(2), glycated haemoglobin A1c &lt;6.0%, never smoker, chronic respiratory disease as a comorbidity and no medication use.
    Conclusions: These data provide details of serum cholesterol levels by risk-factor profile in patients with dyslipidaemia and could add evidence of treatment decisions. (C) 2017 The Authors. Publishing services by Elsevier B.V. on behalf of The Japan Epidemiological Association.

    File: J Epidemiol 2017 Yokomichi H et al. Cholesterol levels in Japanese dyslipidaemic patients in BioBank Japan.pdf

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  • Statin use and all-cause and cancer mortality: BioBank Japan cohort Invited Reviewed Major achievement

    Yokomichi H,Nagai A,Hirata M,Tamakoshi A,Kamatani Y,Kiyohara Y,Matsuda K,Muto K,Ninomiya T,Kubo M,Nakamura Y,BioBank Japan Cooperative Hospital Group,Yamagata Z

    JOURNAL OF EPIDEMIOLOGY   27 ( 3S )   84 - 91   2017.3( ISSN:0917-5040 )

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    Background
    Statins are the first-line agents used to treat patients with high serum low-density lipoprotein cholesterol levels, thus reducing the risk of death from arterial sclerotic cardiovascular disease; however, little is known about the effects of non-statin pharmacological interventions on mortality as well as about the potential protective effects of statin use against cancer death. This work aimed to compare all-cause and cancer mortality among patients with hyperlipidaemia who did and did not receive statin treatment.

    Methods
    Between 2003 and 2007 fiscal years, we recruited Japanese patients diagnosed with hyperlipidaemia from 66 hospitals. Patients in our cohort were followed up for a maximum of 12 years to observe the causes of death. Kaplan–Meier estimates from the baseline were used to compare the mortality of patients based on the administered medicine. All-cause mortality were compared among patients with/without administration of statins and other agents; any-organ and colorectal cancer mortality were compared between patients with/without administration of statins.

    Results
    Our cohort included 41,930 patients with mean ages of 64–66 years and mean body mass indices of 24–25 kg/m2. Patients who received statin monotherapy and were treated with lifestyle modification exhibited nearly identical survival curves, whereas statin use represented a non-significant but potentially protective effect against colorectal cancer-related mortality. The lowest mortality in this cohort was associated with resin monotherapy.

    Conclusions
    Mortality rate has been similar for patients treated with statin monotherapy and lifestyle modification. Statin monotherapy could potentially reduce any-organ- and colorectal cancer-related mortality.

    File: J Epidemiol 2017 Yokomichi H et al. Statin use and all-cause and cancer mortality from BioBank Japan.pdf

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  • Serum glucose, cholesterol and blood pressure levels in Japanese type 1 and 2 diabetic patients: BioBank Japan Invited Reviewed Major achievement

    Yokomichi H,Nagai A,Hirata M,Tamakoshi A,Kamatani Y,Kiyohara Y,Matsuda K,Muto K,Ninomiya T,Kubo M,Nakamura Y,BioBank Japan Cooperative Hospital Group,Yamagata Z

    JOURNAL OF EPIDEMIOLOGY   27 ( 3S )   92 - 97   2017.3( ISSN:0917-5040 )

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    Background: Evidence of characteristics of Japanese patients with diabetes from a large-scale population is necessary. Few studies have compared glycaemic controls, complications and comorbidities between type 1 and 2 diabetic patients. This paper focuses on illustrating a clinical picture of Japanese diabetic patients and comparing glycaemic control and prognoses between type 1 and 2 diabetes using multiinstitutional data.
    Methods: The BioBank Japan Project enrolled adult type 1 and 2 diabetic patients between fiscal years 2003 and 2007. We have presented characteristics, controls of serum glucose, cholesterol and blood pressure, prevalence of complications and comorbidities and survival curves. We have also shown glycaemic controls according to various individual profiles of diabetic patients.
    Results: A total of 558 type 1 diabetic patients and 30,834 type 2 diabetic patients participated in this study. The mean glycated haemoglobin A1c was higher in type 1 diabetes than in type 2 diabetes. In the type 1 diabetic patients, the glycated haemoglobin A1c had no consistent trend according to age and body mass index. The Kaplan-Meier estimates represented a longer survival time from baseline with type 1 diabetes than with type 2 diabetes. Compared with type 1 diabetic patients, type 2 diabetic patients had double the prevalence of macrovascular complications.
    Conclusions: This work has revealed detailed plasma glucose levels of type 1 and 2 diabetic patients according to age, body mass index, blood pressure, serum cholesterol levels and smoking and drinking habits. Our data have also shown that the prognosis is worse for type 2 diabetes than for type 1 diabetes in Japan. (C) 2017 The Authors. Publishing services by Elsevier B.V. on behalf of The Japan Epidemiological Association.

    File: J Epidemiol 2017 Yokomichi H et al. Serum glucose and cholesterol and blood pressure level in Japanese type 1 and 2 diabetes.pdf

    DOI: 10.1016/j.je.2016.12.013

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  • Longitudinal changes in body mass index of children affected by the Great East Japan Earthquake Reviewed International coauthorship Major achievement

    Zheng W, Yokomichi H, Matsubara H, Ishikuro M, Kikuya K, Isojima T, Yokoya S, Tanaka T, Kato N, Chida S, Ono A, Hosoya M, Tanaka S, Kuriyama S, Kure S, Yamagata Z

    INTERNATIONAL JOURNAL OF OBESITY   41 ( 4 )   606 - 612   2017.1( ISSN:0307-0565  eISSN:1476-5497 )

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    Background: The evacuation and disruption in housing caused by the 2011 Great East Japan Earthquake and following nuclear radiation may have influenced child health in many respects. However, studies regarding longitudinal childhood growth are limited. Therefore, in this study we aimed to explore the influence of the earthquake on longitudinal changes in body mass index in preschool children.

    Methods: Participants were children from nursery schools who cooperated with the study in the Iwate, Miyagi and Fukushima prefectures. The exposed group consisted of children who experienced the earthquake during their preschool-age period (4–5 years old). The historical control group included children who were born 2 years earlier than the exposed children in the same prefectures. Trajectories regarding body mass index and prevalence of overweight/obesity were compared between the two groups using multilevel analysis. Differences in the changes in BMI between before and after the earthquake, and proportion of overweight/obesity was compared between the two groups. We also conducted subgroup analysis by defining children with specific personal disaster experiences within the exposed group.

    Results: A total of 9722 children were included in the study. Children in the exposed group had higher body mass indices and a higher proportion of overweight after the earthquake than the control group. These differences were more obvious when confined to exposed children with specific personal disaster experiences.

    Conclusions: Children’s growth and development-related health issues such as increased BMI after natural disasters should evoke great attention.

    File: Int J Obes Zheng W 2017 BMI change at the Great East Japan Earthquakte.pdf

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  • Sensitive detection of hemodynamic failure during orthostatic stress in patients with diabetic polyneuropathy using a mini laser Doppler blood flowmeter Reviewed

    Goma M,Kaneshige M,Ichijo S,Ichijo M,Shindo H,Terada N,Yokomichi H,Yamagata Z,Kitamura K,Shimura H,Kobayashi T

    Journal of the American Society of Hypertension   11 ( 1 )   28 - 37   2017.1( ISSN:1933-1711  eISSN:1878-7436 )

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    Autonomic dysfunction in diabetes is serious but often underestimated. The purpose of this study was to evaluate hemodynamics within the important initial phase just after standing, which cannot be evaluated by conventional instruments for orthostatic hypotension. Earlobe blood flow (EBF), which indirectly reflects the blood pressure response on standing, was evaluated using a mini laser Doppler flowmeter during standing from the sitting position in 58 healthy controls and 56 diabetic patients categorized as without (11), mild (27), and advanced diabetic polyneuropathy (18). The response area of the EBF waveform within 30 seconds after standing was calculated. An increased response area indicates poor recovery of EBF. Response area increased significantly with the degree of neuropathy (P &lt;.001 for linear trend). Orthostatic hypotension was detected in two patients in the mild neuropathy group. The present approach may be sensitive and practical for detecting autonomic dysfunction not detected with the conventional orthostatic test. (C) Copyright 2016 American Society of Hypertension. All rights reserved.

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 社会経済的要因と過体重・肥満との関連 NIPPON DATA2010国民生活基礎調査 社会的要因の検討

    中村富予, 中村保幸, 斎藤重幸, 岡村智教, 柳田昌彦, 由田克士, 喜多義邦, 村上義孝, 横道洋司, 西信雄, 奥田奈賀子, 門田文, 大久保孝義, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)   53‐54 (WEB ONLY)   2017

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  • Diabetes screening intervals based on risk stratification Reviewed

    Sachiko OHDE,Emily McFadden,Gautam A. Deshpande,Hiroshi YOKOMICHI,Osamu TAKAHASHI,Tsuguya FUKUI,Rafael Perera,Zentaro YAMAGATA

    BMC Endocrine Disorders   16   e65   2016.11( ISSN:1472-6823 )

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    Background: Guidelines for frequency of Type 2 diabetes mellitus (DM) screening remain unclear, with proposed screening intervals typically based on expert opinion. This study aims to demonstrate that HbA1c screening intervals may differ substantially when considering individual risk for diabetes.
    Methods: This was a multi-institutional retrospective open cohort study. Data were collected between April 1999 to March 2014 from one urban and one rural cohort in Japan. After categorization by age, we stratified individuals based on cardiovascular disease risk (Framingham 10-year cardiovascular risk score) and body mass index (BMI). We adapted a signal-to-noise method for distinguishing true HbA1c change from measurement error by constructing a linear random effect model to calculate signal and noise of HbA1c. Screening interval for HbA1c was defined as informative when the signal-to-noise ratio exceeded 1.
    Results: Among 96,456 healthy adults, 46,284 (48.0%) were male; age (range) and mean HbA1c (SD) were 48 (30-74) years old and 5.4 (0.4)%, respectively. As risk increased among those 30-44 years old, HbA1c screening intervals for detecting Type 2 DM consistently decreased: from 10.5 (BMI &lt; 18.5) to 2.4 (BMI &gt; 30) years, and from 8.0 (Framingham Risk Score &lt; 10%) to 2.0 (Framingham Risk Score &gt;= 20%) years. This trend was consistent in other age and risk groups as well; among obese 30-44 year olds, we found substantially shorter intervals compared to other groups.
    Conclusion: HbA1c screening intervals for identification of DM vary substantially by risk factors. Risk stratification should be applied when deciding an optimal HbA1c screening interval in the general population to minimize overdiagnosis and overtreatment.

    File: BMC 2016 Ohde S et al. Optimal diabetes screening on risk stratification.pdf

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  • Seasonal variations of Japanese children in nursery school Reviewed

    磯島豪, 加藤則子, 横谷進, 田中敏章, 小野敦史, 横道洋司, 山縣然太郎, 田中総一郎, 松原博子, 石黒真美, 菊谷昌浩, 千田勝一, 細谷光亮, 栗山進一, 呉繁夫

        22 ( 2 )   106 - 106   2016.9

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  • Pubertal timing and a family history of hypertension: Prospective cohort study Reviewed

    Wei ZHENG,Kohta SUZUKI,Miri SATO,Hiroshi YOKOMICHI,Ryoji SHINOHARA,Zentaro YAMAGATA

    PEDIATRICS INTERNATIONAL   58 ( 4 )   284 - 289   2016.6( ISSN:1328-8067  eISSN:1442-200X )

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    BackgroundHypertension is heritable, and genetic factors likely exert an effect from childhood. Puberty is an early life milestone that may relate to adult hypertension. Therefore, this study examined whether there is an association between a family history of hypertension and pubertal growth.
    MethodsThe participants were children from a prospective cohort study called Project Koshu, who were born between 1991 and 1998 in Japan. Data on family history of hypertension, maternal characteristics, birth and early life factors were collected from the questionnaire administered to the mothers at the time of pregnancy registration or medical check-up. Child age at peak height velocity (early or non-early) was calculated from the anthropometric data collected during annual school check-up.
    ResultsData on 919 children (479 boys and 440 girls) were included in the analysis; 478 participants had a family history of hypertension. After adjustment for potential confounders (birth month, maternal body mass index, maternal work status, maternal education, and paternal education), early age at peak height velocity was found to be associated with a family history of hypertension (OR, 1.52; 95% confidence interval (CI): 1.04-2.24; P = 0.03) and specifically, with having at least one maternal hypertensive relative (OR, 1.81; 95%CI: 1.23-2.68; P = 0.003).
    ConclusionsTogether with previous reports on the relationship between puberty and adult hypertension, the present results suggest that the timing of pubertal growth is involved in the process of hypertension development in people with a family history of hypertension. Further confirmative studies are needed.

    File: Pediatr Int 2016 Zheng W Pubertal timing and family history of hypertension from Koshu Project.pdf

    DOI: 10.1111/ped.12821

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  • Postural sway of schizophrenic patients measured by stabilograph and associated factors Reviewed Major achievement

    The Journal of Japan Academy of Health Sciences   19 ( 1 )   24 - 32   2016.6

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  • Impact of the great east Japan earthquake on the body mass index of preschool children: a nationwide nursery school survey Reviewed Major achievement

    Yokomichi H, Zheng W, Matsubara H, Ishikuro M, Kikuya M, Isojima T, Yokoya S, Tanaka T, Kato N, Chida S, Ono A, Hosoya M, Tanaka S, Kuriyama S, Kure S, Yamagata Z

    BMJ Open   6 ( 4 )   e010978   2016.4( ISSN:2044-6055 )

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    DOI: 10.1136/bmjopen-2015-010978

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  • 体重増加後の減少・減少後の増加(Weight Cycling)による糖尿病発症リスクの検討

    横道 洋司, 望月 美恵, 依田 芳起

    糖尿病   59 ( Suppl.1 )   S - 147   2016.4( ISSN:0021-437X  eISSN:1881-588X )

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  • Evaluation of the associations between changes in intraocular pressure and metabolic syndrome parameters: a retrospective cohort study in Japan Reviewed Major achievement

    Yokomichi H, Kashiwagi K, Kitamura K, Yoda Y, Tsuji M, Mochizuki M, Sato M, Shinohara R, Mizorogi S, Suzuki K, Yamagata Z

    BMJ Open   6 ( 3 )   e10360   2016.3( ISSN:2044-6055 )

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    Objective The contributions of highly correlated cardiovascular risk factors to intraocular pressure (IOP) are not clear due to underlying confounding problems. The present study aimed to determine which metabolic syndrome parameters contribute to elevating IOP and to what extent.
    Design Retrospective cohort study.
    Setting A private healthcare centre in Japan.
    Participants Individuals who visited a private healthcare centre and underwent comprehensive medical check-ups between April 1999 and March 2009 were included (20007 in the cross-sectional study and 15747 in the longitudinal study).
    Primary and secondary outcome measures Changes in IOP were evaluated in terms of ageing and changes in metabolic syndrome parameters. Pearson's correlation coefficients and mixed-effects models were used to examine the relationship of changes in IOP with ageing and changes in metabolic syndrome parameters in cross-sectional and longitudinal studies, respectively.
    Results In the cross-sectional study, IOP was negatively correlated with age and positively correlated with waist circumference, high-density lipoprotein cholesterol (HDL-C) levels, triglyceride levels, systolic blood pressure (SBP), diastolic blood pressure (DBP) and fasting plasma glucose (FPG) levels. In the longitudinal multivariate analysis, the associated IOP changes were -0.12 (p&lt;0.0001) mmHg with male sex; -0.59 (p&lt;0.0001) mmHg with 10years of ageing; +0.42 (p&lt;0.0001) mmHg with 1mmol/L increase in HDL-C levels; +0.092 (p&lt;0.0001) mmHg with 1mmol/L increase in triglyceride levels; +0.090 (p&lt;0.0001) mmHg with 10mmHg increase in SBP; +0.085 (p&lt;0.0001) mmHg with 10mmHg increase in DBP; and+0.091 (p&lt;0.0001) mmHg with 1mmol/L increase in FPG levels.
    Conclusions Elevation of IOP was related to longitudinal worsening of serum triglyceride levels, blood pressure and FPG and improvement in serum HDL-C levels.

    File: BMJ Open 2016 Yokomichi H et al. Intraocular pressure and metabolic syndrome. a cross-sectional study from Japan.pdf

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  • The association between meteorological factors and stone-associated pancreatohepatobiliary disease Reviewed

    Eitaro Kume, Fumio Omata, Yuto Shimamura, Kenji Nakamura, Hiroshi Yokomichi, Yoshiyuki Fujita

    The American Journal of Gastroenterology   Suppl1   S35 - S35   2015.10( ISSN:0002-9270 )

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    DOI: 10.1038/ajg.2015.269

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  • Change in standard deviation score of height in Japanese infants Reviewed

    田中敏章, 磯島豪, 横谷進, 加藤則子, 山縣然太朗, 横道洋司, 田中総一郎, 呉繁夫, 松原博子, 小原拓, 石黒真美, 佐藤ゆき, 目時裕仁, 菊谷昌浩, 栗山進一, 千田勝一, 小野敦史, 細谷光亮

        21 ( 2 )   94 - 94   2015.9

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  • Macrosomia is one of risk factors for dental caries in 3-year-old infants in Japan Reviewed Major achievement

    Z Yamagata, H Yokomichi, K Suzuki, T Tanaka

    International Journal of Epidemiology   44 ( Suppl1 )   i77 - i78   2015.8( ISSN:0300-5771  eISSN:1464-3685 )

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    File: Int J Epiemiol 2015 Yamagata Z et al. Macrosomia as dentary caries risk at 3 years old.pdf

    DOI: 10.1093/ije/dyv097.287

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  • Per-oral endoscopic myotomy: A series of 500 patients Reviewed

    Inoue H, Sato H, Ikeda H, Onimaru M, Sato C, Minami H, Yokomichi H, Kobayashi Y,Grimes KL, Kudo S

    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS   221 ( 2 )   256 - 264   2015.8( ISSN:1072-7515  eISSN:1879-1190 )

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    BACKGROUND: After the first case of per-oral endoscopic myotomy (POEM) at our institution in 2008, the procedure was quickly accepted as an alternative to surgical myotomy and is now established as an excellent treatment option for achalasia. This study aimed to examine the safety and outcomes of POEM at our institution.
    STUDY DESIGN: Per-oral endoscopic myotomy was performed on 500 consecutive achalasia patients at our institution between September 2008 and November 2013. A review of prospectively collected data was conducted, including procedure time, myotomy location and length, adverse events, and patient data with short- (2 months) and long-term (1 and 3 years) follow-up.
    RESULTS: Per-oral endoscopic myotomy was successfully completed in all patients, with adverse events observed in 3.2%. Two months post-POEM, significant reductions in symptom scores (Eckardt score 6.0 +/- 3.0 vs 1.0 +/- 2.0, p &lt; 0.0001) and lower esophageal sphincter (LES) pressures (25.4 +/- 17.1 vs 13.4 +/- 5.9 mmHg, p &lt; 0.0001) were achieved, and this persisted at 3 years post-POEM. Gastroesophageal reflux was seen in 16.8% of patients at 2 months and 21.3% at 3-year follow-up.
    CONCLUSIONS: Per-oral endoscopic myotomy was successfully completed in all cases, even when extended indications (extremes of age, previous interventions, or sigmoid esophagus) were used. Adverse events were rare (3.2%), and there were no mortalities. Significant improvements in Eckardt scores and LES pressures were seen at 2 months, 1 year, and 3 years post-POEM. Based on our large series, POEM is a safe and effective treatment for achalasia; there are relatively few contraindications, and the procedure may be used as either first-or second-line therapy. (C) 2015 by the American College of Surgeons

    File: J Am Coll Surg 2015 Inoue H et al. Outcomes of per-oral endoscopic myotomy.pdf

    DOI: 10.1016/j.jamcollsurg.2015.03.057

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  • Sorghum tea does not alter postprandial plasma triglycerides: a randomized, placebo-controlled, crossover clinical trial Reviewed Major achievement

    Hiroshi YOKOMICHI,Tsubasa MATSUOKA,Nobumasa AYUZAWA,Kohta SUZUKI,Miri SATO,Ryoji SHINOHARA,Sonoko MIZOROGI,Zentaro YAMAGATA

    Japanese Pharmacology and Therapeutics   43 ( 7 )   961 - 967   2015.7

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    Other Link: http://www.pieronline.jp/content/article/0386-3603/43070/961

  • Do body mass index trajectories affect the risk of type 2 diabetes? A case-control study Reviewed Major achievement

    Yoshihiko MANO and Hiroshi YOKOMICHI (cofirst authors),Kohta SUZUKI,Atsunori TAKAHASHI,Yoshioki YODA,Masahiro TSUJI,Miri SATO,Ryoji SHINOHARA,Sonoko MIZOROGI,Mie MOCHIZUKI,Zentaro YAMAGATA

    BMC PUBLIC HEALTH   15   e718   2015.7( ISSN:1471-2458 )

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    Background: Although obesity is a well-studied risk factor for diabetes, there remains an interest in whether "increasing body mass index (BMI)," "high BMI per se," or both are the actual risk factors for diabetes. The present study aimed to retrospectively compare BMI trajectories of individuals with and without diabetes in a case-control design and to assess whether increasing BMI alone would be a risk factor.
    Methods: Using comprehensive health check-up data measured over ten years, we conducted a case-control study and graphically drew the trajectories of BMIs among diabetic patients and healthy subjects, based on coefficients in fitted linear mixed-effects models. Patient group was matched with healthy control group at the onset of diabetes with an optimal matching method in a 1:10 ratio. Simple fixed-effects models assessed the differences in increasing BMIs over 10 years between patient and control groups.
    Results: At the time of matching, the mean ages in male patients and controls were 59.3 years [standard deviation (SD) = 9.2] and 57.7 years (SD = 11.2), whereas the mean BMIs were 25.0 kg/m(2) (SD = 3.1) and 25.2 kg/m(2) (SD = 2.9), respectively. In female patients and controls, the mean ages were 61.4 years (SD = 7.9) and 60.1 years (SD = 9.6), whereas the mean BMIs were 24.8 kg/m(2) (SD = 3.5) and 24.9 kg/m(2) (SD = 3.4), respectively. The simple fixed-effects models detected no statistical significance for the differences of increasing BMIs between patient and control groups in males (P = 0.19) and females (P = 0.67). Sudden increases in BMI were observed in both male and female patients when compared with BMIs 1 year prior to diabetes onset.
    Conclusions: The present study suggested that the pace of increasing BMIs is similar between Japanese diabetic patients and healthy individuals. The increasing BMI was not detected to independently affect the onset of type 2 diabetes.

    File: BMC Publ Heal 2015 Mano & Yokomichi et al. BMI trajectory and type 2 diabetes onset. a case-control study.pdf

    DOI: 10.1186/s12889-015-2073-y

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  • Macrosomic Neonates Carry Increased Risk of Dental Caries in Early Childhood: Findings from a Cohort Study, the Okinawa Child Health Study Reviewed Major achievement

    Hiroshi YOKOMICHI,Taichiro TANAKA,Kohta SUZUKI,Tomoki AKIYAMA,Okinawa Child Health Study Gro,Zentaro YAMAGATA

    PLoS One   10 ( 7 )   e0133872   2015.7( ISSN:1932-6203 )

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    Background
    Although many studies have discussed health risks in neonates with a low birth weight, few studies have focused on the risks in neonates with a high birth weight. The objective of this study was to determine whether differences in the incidence of dental caries in early childhood are associated with birth weight status.
    Methods
    A total of 117,175 children born in Okinawa Prefecture, Japan from 1997 to 2007 were included in this study. Medical professionals collected information about birth records, growth and development, parental child-rearing practices and dental health at 3 months, 18 months and 3 years of age. The risk of dental caries among neonates with macrosomia (birth weight &gt;= 4000 g) was compared with that among neonates with normal weight (2500-3999 g). Sensitivity analyses included 'large for gestational age' (LGA, birth weight above the 90th percentile for gestational age), which was relative to 'appropriate for gestational age' (birth weight between 10th and 90th percentiles). Relative risks and relative risk increases were estimated by multivariate Poisson regression.
    Results
    At 3 years of age, the relative risk increases for dental caries after adjusting for confounding factors were 19% [95% confidence interval (CI), 11%-28%, P &lt; 0.001] for macrosomic neonates and 12% (95% CI, 9%-16%, P &lt; 0.001) for LGA neonates.
    Conclusion
    Macrosomia and LGA were associated with an increased risk of dental caries in early childhood. Particular attention should be paid to abnormally large neonates.

    File: Plos One 2015 Yokomichi H et al. Macrosomia as dentary carry risk factor at 3 years old from Japan.pdf

    DOI: 10.1371/journal.pone.0133872

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  • Daily sorghum tea reduces human body fat and plasma glucose: a clinical investigation of the efficacy and safety of long-term intake Reviewed Major achievement

    Hiroshi YOKOMICHI,Tsubasa MATSUOKA,Nobumasa AYUZAWA,Kohta SUZUKI,Miri SATO,Ryoji SHINOHARA,Sonoko MIZOROGI,Zentaro YAMAGATA

    Japanese Pharmacology and Therapeutics   43 ( 7 )   955 - 960   2015.7

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    Other Link: http://www.pieronline.jp/content/article/0386-3603/43070/955

  • 小型レーザドップラ血流計による糖尿病患者での起立時頭部血流測定と自律神経機能検査への応用 Reviewed

    郷間雅樹, 金重勝博, 一條沙耶花, 一條昌志, 新藤英夫, 寺田信幸, 横道洋司, 山縣然太郎, 北村健一郎, 志村浩己, 小林哲郎

    Journal of Japanese Society of Laboratory Medicine   63 ( Suppl )   116 - 116   2015.6( ISSN:0047-1860 )

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  • 可溶型CLEC-2は血小板活性化に伴って生成される 可溶性GPVIとの比較検討

    井上 修, 長田 誠, 中村 純也, 風間 文智, 横道 洋司, 土肥 智貴, 金子 誠, 蔵野 信, 大澤 満, 田村 彰吾, 佐藤 金夫, 高野 勝弘, 宮内 克己, 代田 浩之, 矢冨 裕, 井上 克枝, 尾崎 由基男

    日本血栓止血学会誌   26 ( 2 )   215 - 215   2015.4( ISSN:0915-7441 )

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  • Childhood growth trajectories according to combinations of pregestational weight status and maternal smoking during pregnancy: A multilevel analysis Reviewed

    Kohta SUZUKI,Miri SATO,Wei Zheng,Ryoji SHINOHARA,Hiroshi YOKOMICHI,Zentaro YAMAGATA

    PLoS One   10 ( 2 )   e0118538   2015.2( ISSN:1932-6203 )

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    DOI: doi.org/10.1371/journal.pone.0118538

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  • Maternal smoking during pregnancy and infancy growth: A covariance structure analysis Reviewed

    Wei Zheng,Kohta SUZUKI,Ryoji SHINOHARA,Miri SATO,Hiroshi YOKOMICHI,Zentaro YAMAGATA

    JOURNAL OF EPIDEMIOLOGY   25 ( 1 )   44 - 49   2015.1( ISSN:0917-5040  eISSN:1349-9092 )

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    Background: Smoking during pregnancy is related to fetal constraint and accelerated postnatal growth. However, the pathways between these factors have not been clarified. Pathway analyses that link these factors can help us better understand the mechanisms involved in this association. Therefore, this study aimed to examine pathways between maternal smoking during pregnancy and growth in infancy.
    Methods: Participants were singletons born between 1993 and 2006 in rural Japan. The outcome was the change in weight z-score between birth and 3 years of age. Pathways from maternal smoking and other maternal factors (such as maternal body mass index and work status) to growth in infancy via birth factors (such as birth weight and gestational age) and breastfeeding were examined using structural equation modeling.
    Results: Complete data were available for 1524 children (775 boys and 749 girls). The model fit appeared adequate. Lower birth weight and non-exclusive breastfeeding mediated the association between maternal smoking during pregnancy and rapid growth in infancy. Maternal smoking was also directly linked to rapid growth in infancy (standardized direct effects 0.06, P = 0.002). Taking all pathways into account, the standardized total effect of maternal smoking on growth in infancy was 0.11.
    Conclusions: Maternal smoking during pregnancy may both indirectly, through birth weight and breastfeeding status, and directly influence growth during infancy; however, there may be other pathways that have not yet been identified.

    File: J Epidemiol 2015 Zheng W et al. Maternal smoking and infant growth.pdf

    DOI: 10.2188/jea.JE20140040

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  • 妊娠中の喫煙が児の体格の変化に与える影響: 母親の年齢別マルチレベル解析 Reviewed

    鈴木 孝太,佐藤 美理,溝呂木 園子,Wei Zheng,篠原 亮次,横道 洋司,山縣 然太朗

    日本小児禁煙研究会雑誌   4 ( 2 )   58 - 64   2014.10

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  • Neutrophil gelatinase-associated lipocalin levels associated with cardiovascular disease in chronic kidney disease patients Reviewed

    Fumihiko FURUYA,Hiroki SHIMURA,Hiroshi YOKOMICHI,Kazuya TAKAHASHI,Daiichiro AKIYAMA,Chikako ASAKAWA,Ayako OKAMURA,Ai MOTOSUGI,Kazutaka HARAGUCHI,Zentaro YAMAGATA,Tetsuro KOBAYASHI

    Clinical and Experimental Nephrology   18 ( 5 )   778 - 783   2014.10( ISSN:1342-1751 )

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    DOI: 10.2215/CJN.03530708

    Other Link: https://link.springer.com/article/10.1007/s10157-013-0923-4

  • P-3 重心動揺計を用いて測定した統合失調症患者の重心動揺とその関連要因の検討(ポスターセッション(1),一般演題,第24回日本保健科学学会学術集会)

    古賀 誠, 近藤 尚己, 横道 洋司, 丹羽 正利, 山縣 然太朗

    日本保健科学学会誌   17 ( 0 )   28 - 28   2014.9( ISSN:1880-0211 )

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    DOI: 10.24531/jhsaiih.17.Suppl_28_1

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  • Changes in Intraocular Pressure and Associated Systemic Factors Over 10 Years in Subjects Without Ocular Disease at Baseline Reviewed Major achievement

    Kazuyoshi Kitamura,Hiroshi Yokomichi,Zentaro Yamagata,Masahiro Tsuji,Yoshioki Yoda,Kenji Kashiwagi

    JOURNAL OF GLAUCOMA   23 ( 3 )   185 - 189   2014.7( ISSN:1057-0829  eISSN:1536-481X )

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    Purpose:
    To investigate the changes in intraocular pressure (IOP) and associated factors over 10 years in subjects who participated in health examinations in 1999 and 2008.
    Subjects and Methods:
    Subjects with no clear history of ocular disease and who participated in health examinations at Yamanashi Koseiren Health Care Center, Japan, in 1999 and 2008 were enrolled in this study. IOP was evaluated using a noncontact tonometer. The right eye was analyzed in all subjects. The change in IOP between the 2 examinations and the factors that were significantly associated with the change in IOP were investigated.
    Results:
    A total of 3785 subjects were enrolled (mean age, 50.9 +/- 8.6 y), comprising 2022 males (mean age, 50.3 +/- 8.9 y) and 1763 females (mean age, 51.5 +/- 8.2 y). The mean IOPs of males and females in 1999 were 13.4 +/- 3.1 and 12.8 +/- 2.8 mm Hg, respectively (P &lt; 0.0001). IOP measured in 2008 was significantly lower than that in 1998 in males and females (mean change, -0.8 and -0.6 mm Hg, respectively; P &lt; 0.0001). Univariate regression analysis showed that changes in systolic blood pressure, diastolic blood pressure, total cholesterol, body mass index, and gamma-glutamyl transpeptidase were positively correlated with change in IOP. Multivariate regression analysis showed that the change in IOP was positively associated with the changes in systolic blood pressure, diastolic blood pressure, and body mass index.
    Conclusions:
    IOP decreased significantly with age. Several systemic factors were significantly correlation with the change in IOP.

    DOI: 10.1097/IJG.0b013e3182741c51

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  • Adolescent growth in overweight and non-overweight children in Japan: a multilevel analysis Reviewed

    Wei Zheng,Kohta SUZUKI,Miri SATO,Hiroshi YOKOMICHI,Ryoji SHINOHARA,Zentaro YAMAGATA

    PAEDIATRIC AND PERINATAL EPIDEMIOLOGY   28 ( 3 )   263 - 269   2014.5( ISSN:0269-5022  eISSN:1365-3016 )

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    Background
    A trend towards earlier pubertal growth has been identified along with an increase in childhood obesity rates. The study aimed to identify the differences in growth patterns during adolescence between overweight/obese and non-overweight children in Japan.
    Methods
    The participants were children from a prospective cohort study called Project Koshu, who were born between 1991 and 1998, in Japan. They were classified as overweight/obese or non-overweight according to their body mass index (BMI) in the first grade of elementary school (6-7 years of age) and were followed until graduation from junior high school (14-15 years of age). Anthropometric data were collected at an annual medical check-up in their school. Height gain trajectories were constructed by BMI categories using multilevel analyses. This analysis was stratified by gender.
    Results
    Overall, 111/850 (13.1%) girls and 109/911(12%) boys were defined as overweight/obese at baseline. Approximately 80% of the children were followed until the third grades of junior high school. Overweight/obese girls gained more height in the first half period, reached their peak height gain about a year earlier than non-overweight girls, and experienced an earlier decline in height gain. Similarly, overweight/obese boys gained more height than non-overweight boys initially. Additionally, non-overweight boys maintained a higher rate of height gain from the age at peak height gain, although the age at peak height gain did not differ between the two groups.
    Conclusions
    The overweight/obese children grew faster than the non-overweight children in the early pubertal stages, and the non-overweight children caught up and exceeded in height gain at a later stage.

    File: Paediatr Perinat Epidemiol 2014 Zheng W et al. Adolescent growth in Japan from Koshu Project.pdf

    DOI: 10.1111/ppe.12116

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  • Pandemic Influenza A (H1N1) 2009 Vaccine does not Increase the Mortality Rate of Idiopathic Interstitial Pneumonia: A Matched Case-Control Study Reviewed Major achievement

    Hiroshi Yokomichi,Shintaro Kurihara,Tetsuji Yokoyama,Eisuke Inoue,Keiko Tanaka-Taya,Shigeru Kono,Zentaro Yamagata

    PLoS One   9 ( 2 )   e88927   2014.2( ISSN:1932-6203 )

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    Background: Evidence regarding the mortality rate after administration of the pandemic influenza A (H1N1) 2009 vaccine on patients with underlying diseases is currently scarce. We conducted a case-control study in Japan to compare the mortality rates of patients with idiopathic interstitial pneumonia after the vaccines were administered and were not administered.
    Methods: Between October 2009 and March 2010, we collected clinical records in Japan and conducted a 1:1 matched case-control study. Patients with idiopathic interstitial pneumonia who died during this period were considered case patients, and those who survived were considered control patients. We determined and compared the proportion of each group that received the pandemic influenza A (H1N1) 2009 vaccine and estimated the odds ratio. Finally, we conducted simulations that compensated for the shortcomings of the study associated with adjusted severity of idiopathic interstitial pneumonia.
    Results: The case and control groups each comprised of 75 patients with idiopathic interstitial pneumonia. The proportion of patients who received the pandemic influenza A (H1N1) 2009 vaccine was 30.7% and 38.7% for the case and control groups, respectively. During that winter, the crude conditional odds ratio of mortality was 0.63 (95% confidence interval, 0.25-1.47) and the adjusted conditional odds ratio was 1.18 (95% confidence interval, 0.33-4.49); neither was significant. The simulation study showed more accurate conditional odds ratios of 0.63-0.71.
    Conclusions: In our study, we detected no evidence that the influenza A (H1N1) 2009 vaccine increased the mortality rate of patients with idiopathic interstitial pneumonia. The results, however, are limited by the small sample size and low statistical power. A larger-scale study is required.

    File: Plos One 2014 Yokomichi H et al. Pandemic influenza vaccine and mortality in idiopathic interstitial pneumonia. case-control study.pdf

    DOI: 10.1371/journal.pone.0088927

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  • Effect of maternal smoking cessation before and during early pregnancy on fetal and childhood growth Reviewed

    Kohta SUZUKI,Miri SATO,Wei Zheng,Ryoji SHINOHARA,Hiroshi YOKOMICHI,Zentaro YAMAGATA

    JOURNAL OF EPIDEMIOLOGY   24 ( 1 )   60 - 66   2014.1( ISSN:0917-5040  eISSN:1349-9092 )

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    Background: Maternal smoking during pregnancy is a major cause of intrauterine growth restriction and childhood obesity, but only a few studies have examined the association of smoking cessation before and during pregnancy with fetal and childhood growth. We examined this association in a prospective cohort study in Japan.
    Methods: Our study included children born between 1991 and 2006 and their mothers. Using a questionnaire, maternal smoking status was recorded at pregnancy. The anthropometric data of the children were collected during a medical check-up at age 3 years. Multiple linear and logistic regression models were used for data analysis stratified by sex.
    Results: In total, 2663 mothers reported their smoking status during early pregnancy, and data were collected from 2230 (83.7%) children at age 3 years. Maternal smoking during pregnancy was associated with a significant reduction in birth weight (approximately 120-150 g). Body mass index at age 3 years was significantly higher among boys born to smoking mothers than among boys born to nonsmoking mothers. Maternal smoking during pregnancy was associated with overweight at age 3 years among boys (adjusted odds ratio, 2.4; 95% CI, 1.03-5.4). However, among women who stopped smoking in early pregnancy, there was no increase in the risks of a small for gestational age birth or childhood overweight at age 3 years.
    Conclusions: Children born to mothers who stopped smoking before or during early pregnancy had appropriate fetal and childhood growth.

    File: J Epidemiol 2014 Suzuki K et al. Maternal smoking cessation and child grwoth.pdf

    DOI: 10.2188/jea.JE20130083

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  • 妊娠前後の喫煙状況の変化と、母親の再喫煙にパートナーの禁煙が与える影響の検討 Reviewed

    鈴木 孝太,佐藤 美理,篠原 亮次,溝呂木 園子,横道 洋司,山縣 然太朗

    日本小児禁煙研究会雑誌   3 ( 2 )   66 - 71   2013.10

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  • Multilevel longitudinal analysis of sex differences in height gain and growth rate changes in Japanese school-aged children Reviewed

    Zheng W, Suzuki K, Yokomichi H, Sato M, Yamagata Z

    JOURNAL OF EPIDEMIOLOGY   23 ( 4 )   275 - 279   2013.9( ISSN:0917-5040 )

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    Background: Determining standard pubertal growth patterns using longitudinal anthropometric measures is important in growth assessment. We used an appropriate repeated-measurements method to identify height growth patterns in Japanese school-aged girls and boys.
    Methods: The participants were children born during the period from 1991 through 1999 who had entered the first grade of elementary school in the Enzan district in Koshu City, Japan. This study was part of the Project Koshu cohort study. Height was measured annually in April from the first grade of elementary school (age, 6-7 years) to the third grade of junior middle school (age, 14-15 years). Height gain and growth rate trajectories in boys and girls were constructed using multilevel analysis.
    Results: In total, 1984 children (1036 boys and 948 girls) were included in this study. Height in boys and girls was similar at age 6.5 to 9.5 years. Girls subsequently grew faster and were taller than boys at age 10.5 to 11.5 years. Starting at age 12.5 years, male height caught up and exceeded female height. Height gain trajectories showed that annual height gain among girls increased slowly and peaked during age 9.5 to 11.5 years, while male height gains declined slightly at first and peaked at age 11.5 to 12.5 years. Sex differences in height gains were significant during the period from age 7.5 to 14.5 years (P &lt; 0.0001). Growth rate and height gain trajectories were similar between sexes.
    Conclusions: Sex differences in growth trajectory were significant, and female height gain peaked approximately 2 years earlier than male height gain.

    File: J Epidemiol 2013 Zheng W et al. Sex difference in height gain and growth rate in Japanese schoolers from Koshu Project.pdf

    DOI: 10.2188/jea.JE20120164

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  • Medication possession ratio and its related factors among Japanese glaucoma patients Reviewed Major achievement

    Kazuyoshi Kitamura, Hiroshi Yokomichi, Zentaro Yamagata, Kenji Kashiwagi

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   54 ( 15 )   3500 - 3500   2013.6( ISSN:0146-0404 )

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    Other Link: https://iovs.arvojournals.org/article.aspx?articleid=2148290

  • An improved statistical method to estimate usual intake distribution of nutrients by age group Reviewed Major achievement

    Yokomichi H, Yokoyama T, Takahashi K, Yoshiike N, Yamagata Z, Tango T

    American Journal of Epidemiology   177 ( Suppl11 )   S139 - S139   2013.6( ISSN:0002-9262 )

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (international conference proceedings)   Publisher:Oxford University Press  

    File: 2013 Society for Epidemiologic Studies Proceedings 139.pdf

    DOI: 10.1093/aje/kwt103

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  • An improved statistical method to estimate usual intake distribution of nutrients by age group Reviewed Major achievement

    Hiroshi YOKOMICHI,Tetsuji YOKOYAMA,Kunihiko TAKAHASHI,Nobuo YOSHIIKE,Zentaro YAMAGATA,Toshiro TANGO

        3 ( 2 )   1000196   2013.6( ISSN:2155-9600 )

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    Other Link: https://www.omicsonline.org/an-improved-statistical-method-to-estimate-usual-intake-distribution-of-nutrients-by-age-group-2155-9600.1000196.php?aid=11927

  • タカキビ抽出液摂取による糖尿病改善効果 Reviewed

    松岡翼, 鮎澤信昌, 内松大輔, 横道洋司, 山縣然太朗

    日本未病システム学会雑誌   13 ( Suppl )   161 - 161   2013.4

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  • Comparing the medical professional's intervention to noncommunicable diseases at comprehensive vs. general health checkups Reviewed

    Miyazaki A, Shimura H, Yokomichi H, Wakabayashi C, Shimura H, Iwamura Y, Yamagata Z, Tagusagawa M, Kobayashi T

    Ningen Dock   27 ( 2 )   423 - 423   2012.12( ISSN:1880-1021 )

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    Other Link: https://www.jstage.jst.go.jp/browse/ningendock/27/2/_contents/-char/en

  • Developmental Trajectories of Body Mass Index Among Japanese Children and Impact of Maternal Factors during Pregnancy Reviewed

    Chiyori Haga,Naoki Kondo,Kohta Suzuki,Miri Sato,Daisuke Ando,Hiroshi Yokomichi,Taichiro Tanaka,Zentaro Yamagata

    PLoS One   7 ( 12 )   e5189   2012.10( ISSN:1932-6203 )

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    Background: The aims of this study were to 1) determine the distinct patterns of body mass index (BMI) trajectories in Japanese children, and 2) elucidate the maternal factors during pregnancy, which contribute to the determination of those patterns.
    Methodology/Principal Findings: All of the children (1,644 individuals) born in Koshu City, Japan, between 1991 and 1998 were followed in a longitudinal study exploring the subjects' BMI. The BMI was calculated 11 times for each child between birth and 12 years of age. Exploratory latent class growth analyses were conducted to identify trajectory patterns of the BMI z-scores. The distribution of BMI trajectories were best characterized by a five-group model for boys and a six-group model for girls. The groups were named "stable thin," "stable average," "stable high average," "progressive overweight," and "progressive obesity" in both sexes; girls were allocated to an additional group called "progressive average." Multinomial logistic regression found that maternal weight, smoking, and skipping breakfast during pregnancy were associated with children included in the progressive obesity pattern rather than the stable average pattern. These associations were stronger for boys than for girls.
    Conclusions/Significance: Multiple developmental patterns in Japanese boys and girls were identified, some of which have not been identified in Western countries. Maternal BMI and some unfavorable behaviors during early pregnancy may impact a child's pattern of body mass development. Further studies to explain the gender and regional differences that were identified are warranted, as these may be important for early life prevention of weight-associated health problems. Citation: Haga C, Kondo N, Suzuki K, Sato M, Ando D, et al. (2012) Developmental Trajectories of Body Mass Index Among Japanese Children and Impact of Maternal Factors during Pregnancy. PLoS ONE 7(12): e51896. doi: 10.1371/journal.pone.0051896

    File: Plos One 2012 Haga C et al. BMI trajectories of Japanese children and associated maternal factors from Koshu Project.pdf

    DOI: 10.1371/journal.pone.0051896

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    Other Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051896

  • Safety of the Influenza A(H1N1) 2009 Vaccine in Chronic Obstructive Pulmonary Disease: A Matched Case-Control Study Reviewed Major achievement

    Hiroshi YOKOMICHI,Shintaro Kurihara,Tetsuji Yokoyama,Eisuke Inoue,Keiko Tanaka-Taya,Shigeru Kono,Zentaro YAMAGATA

        3 ( 5 )   e148   2012.10( ISSN:2157-7560 )

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    Background: The safety of influenza A (H1N1) 2009 among chronic obstructive pulmonary disease (COPD) patients has not been investigated yet. Our objective was to investigate the safety of the A (H1N1) 2009 vaccine, especially for mortality after vaccination. Methods: From October 2009 to March 2010, we collected records from all Japanese hospitals registered in the Japanese Respiratory Society. We conducted a 1:1 matched case-control study. Patients with COPD who died in the study period were determined as case group patients (n=36). Patients with COPD who survived the study period were determined as control group patients (n=36). In the control group selection process, we selected age, sex, period of home oxygen therapy (measure for COPD severity), hospital, and calendar time as matching factors. We then compared the proportion of patients who received the influenza A (H1N1) 2009 vaccine in each group and evaluated the conditional odds ratio. Results: Both the case and control groups had 36 COPD patients, 32 of whom were men. The mean age was 76.6 years (SD=8.6) in the case group and 76.9 years (SD=8.3) in the control group. The mean period of home oxygen therapy in both groups was 1.8. The proportion of patients receiving A (H1N1) 2009 vaccinations was 47.2% in the case group and 63.9% in the control group. The crude conditional odds ratio of mortality in the winter was 0.33 (95% confidence interval: 0.06-1.34) and adjusted conditional odds ratio was 0.37 (95% confidence interval: 0.09-1.52) with no significance. Conclusions: Our study detected no statistically increased risk of mortality after influenza A (H1N1) 2009 vaccination among COPD patients. The results are, however, limited by the small sample size and low statistical power. A similar larger-scale study is needed in the future to confirm our findings. © 2012 Yokomichi H, et al.

    File: J Vaccines Vaccination 2012 Yokomichi H et al. Pandemic influenza vaccinationa and mortality in COPD from Japan. a case-control study.pdf

    DOI: 10.4172/2157-7560.1000148

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    Other Link: https://www.omicsonline.org/safety-of-the-influenza-a-h1n12009-vaccine-in-chronic-obstructive-pulmonary-disease-a-matched-case-control-study-2157-7560.1000148.php?aid=8597

  • Prevalence of birth defects and risk-factor analysis from a population-based survey in inner Mongolia, China Reviewed

    Xingguang Zhang,Li Su,Siqintuya Wu,Xiaojin Hao,Shuyi Guo,Kohta SUZUKI,Hiroshi YOKOMICHI,Zentaro YAMAGATA

    BMC Pediatrics   12 ( 12 )   e125   2012.8( ISSN:1471-2431 )

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    Background: Birth Defects are a series of diseases that seriously affect children's health. Birth defects are generally caused by several interrelated factors. The aims of the article is to estimate the prevalence rate and types of birth defects in Inner Mongolia, China, to compare socio-demographic characteristics among the children with birth defects and to analyze the association between risk factors and birth defects.
    Methods: Data used in this study were obtained through baseline survey of Inner Mongolia Birth Defects Program, a population-based survey conducted from 2005 to 2008. The survey used cluster sampling method in all 12 administrative districts of Inner Mongolia. Sampling size is calculated according to local population size at a certain percentage. All live births, stillbirths and abortions born from October 2005 to September 2008, whose families lived in Inner Mongolia at least one year, were included. The cases of birth defects were diagnosed by the clinical doctors according to their experiences with further laboratory tests if needed. The inclusion criteria of the cases that had already dead were decided according to death records available at local cites. We calculated prevalence rate and 95% confidence intervals of different groups. Outcome variable was the occurrence of birth defects and associations between risk factors and birth defects were analyzed by using Poisson regression analysis.
    Results: 976 children with birth defects were diagnosed. The prevalence rate of birth defects was 156.1 per 10000 births (95%CI: 146.3-165.8). The prevalence rate of neural tube defect (20.1 per 10000 births) including anencephaly (6.9 per 10000), spina bifida (10.6 per 10000), and encephalocele (2.7 per 10000) was the highest, followed by congenital heart disease (17.1 per 10000). The relative risk (RR) for maternal age less than 25 was 2.22 (95%CI: 2.05, 2.41). The RR of the ethnic Mongols was lower than Han Chinese (RR: 0.84; 95%CI: 0.80-0.89). The RR of the third and second pregnancy was significantly higher than the first pregnancy while a slight difference between the second and the first pregnancy was also found. Alcohol drinking of mothers, familial inheritance and living area were also found to be related to the occurrence of the birth defects.
    Conclusions: Relatively higher birth defect rates were found in Inner Mongolia. This study found that maternal age less than 25, alcohol drinking, familiar inheritance, lower education level of mothers, times of pregnancies and living in rural areas may increase the risk of birth defects. Ethnic Mongols were less likely to have birth defects than Han Chinese.

    File: BMC Pediatrics Birth defect prevalence and associated factors in Inner Mongolia, China.pdf

    DOI: 10.1186/1471-2431-12-125

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    Other Link: https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-12-125

  • 高齢者における所得の相対的剥奪と死亡リスク-AGES追跡研究- Reviewed

    近藤 尚己,近藤 克則,横道 洋司,山縣 然太朗

    医療と社会   22 ( 1 )   91 - 101   2012.4

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    Other Link: https://www.jstage.jst.go.jp/article/iken/22/1/22_1_91/_article/-char/en

  • 5歳時の食習慣が小学校4年生の肥満に及ぼす要因-甲州市母子保健長期縦断研究より- Reviewed

    古閑 美奈子,鈴木 孝太,佐藤 美理,新井 孝子,横道 洋司,近藤 尚己,山縣 然太朗

    臨床栄養   120 ( 1 )   105 - 110   2012.1

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    Other Link: https://mol.medicalonline.jp/archive/search?jo=aa7rinek&ye=2012&vo=120&issue=1

  • 糖尿病患者における夕食から就寝および起床から朝食までの時間とHbA1c、GAとの関連

    真野 芳彦, 田中 太一郎, 近藤 尚己, 鈴木 考太, 横道 洋司, 佐藤 美理, 永井 亜貴子, 山縣 然太朗

    日本公衆衛生学会総会抄録集   70回   179 - 179   2011.10( ISSN:1347-8060 )

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  • Exploring BMI trajectory patterns of children and effects of maternal BMI and behaviour during pregnancy: a trajectory analysis of Japanese birth cohort Reviewed

    C Haga, N Kondo, K Suzuki, M Sato, D Ando, T Tanaka, A Nagai, H Yokomichi, Z Yamagata

    Obesity Reviews   12 ( Suppl1 )   93 - 93   2011.5( ISSN:1467-7881 )

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    Other Link: https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1467-789X.2011.00889.x

  • 5歳時の食習慣が小学4年時の肥満に及ぼす要因 甲州市母子保健長期縦断研究より

    古閑 美奈子, 鈴木 孝太, 佐藤 美理, 横道 洋司, 田中 太一郎, 近藤 尚己, 山縣 然太朗

    日本公衆衛生学会総会抄録集   69回   301 - 301   2010.10( ISSN:1347-8060 )

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  • A New Method to Estimate the Proportion of Nutritionally-at-risk Individuals in a Population Reviewed Major achievement

    Hiroshi YOKOMICHI

    Journal of National Institute of Public Health   57 ( 3 )   298 - 299   2008.9

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    Other Link: https://www.niph.go.jp/journal/data/57-3/e57-3.html

  • Physician's attitudes towards disclosure of cancer diagnosis to elderly patients: a report from Tokyo, Japan Reviewed

    S Kawakami, G Arai, K Ueda, Y Murai, H Yokomichi, M Aoshima, K Takagi

    ARCHIVES OF GERONTOLOGY AND GERIATRICS   33 ( 1 )   29 - 36   2001.7( ISSN:0167-4943 )

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    Physicians' attitudes towards the disclosure of a cancer diagnosis to 114 consecutive patients (age range, 65-93 years; median 78 years) admitted to the Tokyo Metropolitan Tama Geriatric Hospital from April 1994 to May 1995 were analyzed utilizing a questionnaire administered to the attending physicians. Eighty-seven patients (76%) had been informed of their diagnosis before the initiation of cancer treatment, while 27 patients (24%) were not told. 'To carry out the treatment under patient's understanding' and 'consideration for patient's quality of life' were the major reasons for diagnosis disclosure, while 'lack of patient's ability to understand the information' and 'family's wish that the patient not be informed of the truth' were the major reasons for non-disclosure. Dementia, deteriorated performance status, and non-curability were major factors related to non-disclosure. Even with decisional ability, 15% of patients were not told their cancer diagnosis because wishes of their families were preferred. The current results suggest that telling cancer diagnosis to the elderly patients will not yield negative attitude of the patients and that there is no rationale for physicians to hesitate to disclose cancer diagnosis merely because of patient's high age. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Books and Other Publications

  • Encouraging cross-disciplinary collaboration and innovation in epidemiology in Japan Reviewed International journal

    Haque M, Razzaque MS, Mjumder AA( Role: Contributor ,  Original_author: Yokomichi H, Mochizuki M, Yamagata Z)

    Frontiers Media SA  2023.4 

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    Total pages:7   Responsible for pages:96-102   Language:English   Book type:Scholarly book

    DOI: 10.3389/fpubh. 2021.641882

  • Easy Statistics for reading scientific papers, 3rd ed.

    Toshiyuki Ojima, Hiroshi Yokomichi, Yoshikazu Nakamura et al.( Role: Joint WorkChapters 3 and 13)

    Diagnosis and Treatment Ltd.  2019.3 

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    Language:Japanese   Book type:Textbook, survey, introduction

  • Generalized, Linear, and Mixed Models Major achievement

    Doi M, Yokomichi H, Aoyama Y, Ioji T, Nakamura R, Yoshida K, Shiroiwa K, Matsushita I, Nishiyama T, Inoue E, Uehara H, Yamaguchi R, Sakai M( Role: Joint Translation Chapters 1 and 14)

    CAC  2011.12 

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Presentations

  • 我が国の1型糖尿病児末期腎症は、急性発症型より緩徐発症型が多い-北海道の長期予後調査から明らかにされたこと-

    松浦信夫, 横道洋司, 伊藤 善也, 鈴木 滋, 望月美恵, 母坪智行

    日本小児・思春期糖尿病学会年次学術集会  2024.7 

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  • 北海道における小児糖尿病児の長期予後調査-特に死亡例、末期腎不全についての解析 Invited

    松浦信夫, 横道洋司, 伊藤 善也, 小池明美, 望月恵美, 北海道内, 歳未満発症, 型糖尿病児の長期予後に関する研究班

    第71回日本小児保健協会学術集会  2024.6 

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  • 小児1型糖尿病のHbA1cに影響を与える因子-施設間の 差異を加味したマルチレベル解析による第5コホート登 録時データの検討

    後藤元秀, 山本幸代, 齋藤玲子, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    第67回日本糖尿病学会年次学術集会  2024.5 

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  • 日本における小児1型糖尿病治療の経時的推移と血糖コ ントロールの関連:小児インスリン治療研究会第5コ ホート登録症例での検討

    山本幸代, 後藤元秀, 齋藤玲子, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    第67回日本糖尿病学会年次学術集会  2024.5 

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  • 小児期発症1型糖尿病児の長期予後調査―北海道コホー トにおける末期腎不全の疫学―

    松浦信夫, 横道洋司, 伊藤善也, 母坪智行, 鈴木滋, 望月美恵

    第67回日本糖尿病学会年次学術集会  2024.5 

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  • 小児1型糖尿病のインスリン投与法の変化と血糖の推移 の検討:小児インスリン治療研究会第5コホートより

    齋藤玲子, 山本幸代, 後藤元秀, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    第67回日本糖尿病学会年次学術集会  2024.5 

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  • 北海道に於ける小児糖尿病児の長期予後調査 ー特に突然死症例についてー Invited

    松浦信夫, 横道洋司, 伊藤 善也, 鈴木滋, 望月美恵, 母坪智行

    第2回日本小児内分泌学会北海道地方会  2024.1 

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  • アレルゲンとビタミンDを考慮に入れた生まれた季節と花粉症、アレルギー性鼻炎との関連:エコチル調査よりアレルゲンとビタミンDを考慮に入れた生まれた季節と花粉症、アレルギー性鼻炎との関連:エコチル調査より

    小島令嗣, 篠原亮次, 久島萌, 小田和早苗, 秋山有佳, 大岡忠生, 堀内清華, 三宅邦夫, 横道洋司, 山縣然太朗

    第60回日本小児アレルギー学会学術大会  2023.11 

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  • アレルゲンとビタミンDを考慮に入れた生まれた季節と花粉症、アレルギー性鼻炎との関連:エコチル調査よりアレルゲンとビタミンDを考慮に入れた生まれた季節と花粉症、アレルギー性鼻炎との関連:エコチル調査より

    小島令嗣 , 篠原亮次 , 久島萌 , 小田和早苗 , 秋山有佳 , 大岡忠生 , 堀内清華 , 三宅邦夫 , 横道洋司 , 山縣然太朗

    第60回日本小児アレルギー学会学術大会  2023.11 

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  • 糖尿病・脂質異常症でのアレルギー疾患有病率: BioBank Japan Major achievement

    横道洋司, 小島令嗣, 秋山有佳, 久島萌, 堀内清華, 大岡忠生, 篠原亮次, 山縣然太朗

    第82回日本公衆衛生学会総会  2023.11 

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  • 糖尿病・脂質異常症でのアレルギー疾患有病率: BioBank Japan Major achievement

    横道洋司 , 小島令嗣 , 秋山有佳 , 久島萌 , 堀内清華 , 大岡忠生 , 篠原亮次 , 山縣然太朗

    The 82th Annual Meeting of Japanese Society of Public Health  2023.11 

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    Event date: 2023.10 - 2023.11

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  • ハウスダスト中の鶏卵タンパク量に関係する要因:エコチル調査より

    小島令嗣, 篠原亮次, 久島萌, 小田和早苗, 秋山有佳, 大岡忠生, 堀内清華, 三宅邦夫, 横道洋司, 山縣然太朗

    第82回日本公衆衛生学会総会  2023.11 

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  • 糖尿病・脂質異常症でのアレルギー疾患有病率:BioBank Japan

    横道洋司, 小島令嗣, 秋山有佳, 久島萌, 堀内清華, 大岡忠生, 篠原亮次, 山縣然太朗

    The 82nd Annual Meeting of Japanese Society of Public Health  2023.11 

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  • ハウスダスト中の鶏卵タンパク量に関係する要因:エコチル調査より

    小島令嗣 , 篠原亮次 , 久島萌 , 小田和早苗 , 秋山有佳 , 大岡忠生 , 堀内清華 , 三宅邦夫 , 横道洋司 , 山縣然太朗

    The 82th Annual Meeting of Japanese Society of Public Health  2023.11 

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  • 日本における小児1型糖尿病治療の経時的推移とコントロールの関連:小児インスリン治療研 究会登録例の検討

    山本幸代, 後藤元秀, 齋藤玲子, 伊藤善也, 横道洋司, 川名宏, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 菊池透

    第56回日本小児内分泌学会学術集会  2023.10 

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  • 小児1型糖尿病での治療方法がHbA1cに与える影響-施設間の差異を加味したマルチレベル 解析-

    後藤元秀, 山本幸代, 齋藤玲子, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    第56回日本小児内分泌学会学術集会  2023.10 

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  • 小児1型糖尿病のインスリン投与法の変化とその後血糖の変化:小児インスリン治療研究会第 5コホートより

    齋藤玲子, 山本幸代, 後藤元秀, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    第56回日本小児内分泌学会学術集会  2023.10 

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  • High incidence of end-stage renal disease in slowly progressive childhood-onset type 1 diabetes: a cohort study in Japan Major achievement

    Yokomichi H, Mochizuki M, Ito Y, Suzuki S, Yamagata Z, Matsuura N

    International Diabetes Federation Western Pacific Region Congress 2023  2023.7 

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  • Pharmacokinetics of intranasal insulin administration during cardiac surgery: dose escalation study

    Nakadate Y, Kawakami A, Oguchi T, Omiya K, Yokomichi H, Nakajima H, Matsukawa T

    The 2023 Canadian Anesthesiology Society Annual Meeting  2023.6 

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  • グリコアルブミン/HbA1c比は長期間安定した各個人固有のglycation gapの指標である

    武者育麻, 望月美恵, 國米崇秀, 赤塚淳弥, 小林浩司, 鈴木滋, 小山さとみ, 菅原大輔, 小林基章, 横道洋司, 松浦信夫, 杉原茂孝, 菊池透, 雨宮伸

    The 66th Annual Meeting of the Japan Diabetes Society  2023.5  鹿児島大学糖尿病・内分泌学講座

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    Event date: 2023.5

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kagoshima  

  • グリコアルブミン/HbA1c比は長期間安定した各個人固有のglycation gapの指標である

    武者育麻, 望月 美恵, 國米 崇秀, 赤塚 淳弥, 小林 浩司, 鈴木 滋, 小山 さとみ, 菅原 大輔, 小林 基章, 横道 洋司, 松浦 信夫, 杉原 茂孝, 菊池 透, 雨宮 伸

    第66回日本糖尿病学会年次学術集会  2023.5 

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  • 小児期発症1型糖尿病児は成人して過体重(3型糖尿病)に移行するか?

    松浦信夫, 伊藤 善也, 母坪 智行, 鈴木 滋, 横道 洋司, 望月 美恵, 吉岡 成人

    第66回日本糖尿病学会年次学術集会  2023.5 

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  • 日本人小児・思春期1型糖尿病の出生体重は,Large for gestational ageの頻度が高い

    川名宏, 山本 幸代, 伊藤 善也, 横道 洋司, 立川 恵美子, 齋藤 朋洋, 滝島 茂, 後藤 元秀, 齋藤 玲子, 堀川 玲子, 菊池 透

    第66回日本糖尿病学会年次学術集会  2023.5 

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  • Mortality and dialysis incidence of childhood-onset type 1 diabetes: Hokkaido IDDM Registry Major achievement

    Yokomichi H, Mochizuki M, Ito Y, Suzuki S, Yamagata Z, Matsuura N

    The 33rd Meeting of the Japan Epidemiological Association  2023.2  Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine

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    Event date: 2023.2

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Act City Hamamatsu  

  • Mortality and dialysis incidence of childhood-onset type 1 diabetes: Hokkaido IDDM Registry Major achievement

    Yokomichi H, Mochizuki M, Ito Y, Suzuki S, Yamagata Z, Matsuura N

    The 33rd Meeting of the Japan Epidemiological Association  2023.2 

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  • 北海道に於ける小児糖尿病児の長期予後調査ー特に突然死症例についてー

    松浦信夫、横道洋司、伊藤 善也、鈴木 滋、望月美恵、母坪智行、北海道内15歳未満発症1型糖尿病児の長期予後に関する研究班

    第1回日本小児内分泌学会北海道地方会  2023.1  Sapporo Medical University

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    Event date: 2023.1

    Language:Japanese   Presentation type:Oral presentation(keynote)  

  • 北海道に於ける小児糖尿病児の長期予後調査ー特に突然死症例についてー

    松浦信夫, 横道洋司, 伊藤 善也, 鈴木 滋, 望月美恵, 母坪智行, 北海道内, 歳未満発症, 型糖尿病児の長期予後に関する研究班

    第1回日本小児内分泌学会北海道地方会  2023.1  Sapporo Medical University

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  • 道内発症小児糖尿病児の長期予後調査を終えてー調査で何が分かったかー

    松浦信夫, 横道洋司, 伊藤 善也, 鈴木 滋, 母坪智行, 吉岡成人, 北海道内, 歳未満発症, 型糖尿病児の長期予後に関する研究班

    日本小児科学会第315回北海道地方会  2023.1  Sapporo Medical University

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  • 北海道における小児糖尿病児の長期予後調査ー死亡例についての解析ー

    Y松浦信夫, 横道洋司, 伊藤善也, 鈴木滋, 望月美恵, 母坪智行

    The 55th Annual Scientific Meeting of the Japanese Society for Pediatric Endocrinology  2022.11  Department of Pediatrics, Faculty of Medicine, Keio University

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Pacifico Yokohama  

  • 北海道における小児糖尿病児の長期予後調査ー死亡例についての解析ー

    Y松浦信夫, 横道洋司, 伊藤善也, 鈴木滋, 望月美恵, 母坪智行

    The 55th Annual Scientific Meeting of the Japanese Society for Pediatric Endocrinology  2022.11  Department of Pediatrics, Faculty of Medicine, Keio University

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    Venue:Pacifico Yokohama  

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  • 1 型糖尿病の初発時における臨床像の年代別変化:小児インスリン治療研究会第3 ~ 5 コホート登録症例での解析

    齋藤玲子, 山本幸代, 後藤元秀, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    The 55th Annual Scientific Meeting of the Japanese Society for Pediatric Endocrinology  2022.11  Department of Pediatrics, Faculty of Medicine, Keio University

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Pacifico Yokohama  

  • 1 型糖尿病の初発時における臨床像の年代別変化:小児インスリン治療研究会第3 ~ 5 コホート登録症例での解析

    齋藤玲子, 山本幸代, 後藤元秀, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    The 55th Annual Scientific Meeting of the Japanese Society for Pediatric Endocrinology  2022.11  Department of Pediatrics, Faculty of Medicine, Keio University

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    Venue:Pacifico Yokohama  

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  • What's happening in medical statistics Invited Major achievement

    Yokomichi H

    The 55th Annual Scientific Meeting of the Japanese Society for Pediatric Endocrinology  2022.11  Department of Pediatrics, Faculty of Medicine, Keio University

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    Event date: 2022.11

    Language:Japanese   Presentation type:Public discourse, seminar, tutorial, course, lecture and others  

    Venue:Pacifico Yokohama  

  • Be clearly worried in medical statistics Invited Major achievement

    Hiroshi Yokomichi

    The 55th annual scientific meeting of the Japanese Society for Pediatric Endocrinology  2022.11 

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    Language:Japanese   Presentation type:Public discourse, seminar, tutorial, course, lecture and others  

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  • 道内発症小児糖尿病児の長期予後調査を終えてー調査で何が分かったかー

    松浦信夫、横道洋司、伊藤 善也、鈴木 滋、母坪智行、吉岡成人、北海道内15歳未満発症1型糖尿病児の長期予後に関する研究班

    日本糖尿病学会第56回北海道地方会  2022.10  Hokkaido University

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:札幌プリンスホテル  

  • 道内発症小児糖尿病児の長期予後調査を終えてー調査で何が分かったかー

    松浦信夫, 横道洋司, 伊藤 善也, 鈴木 滋, 母坪智行, 吉岡成人, 北海道内, 歳未満発症, 型糖尿病児の長期予後に関する研究班

    日本糖尿病学会第56回北海道地方会  2022.10 

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  • 1歳時のスクリーンタイムと3歳時の自閉スペクトラム症との関連:エコチル調査より

    久島萌, 小島令嗣, 篠原亮次, 堀内清華, 小田和早苗, 大岡忠生, 秋山有佳, 横道洋司, 山縣然太朗

    The 81th Annual Meeting of Japanese Society of Public Health  2022.10  Department of Health Sciences, University of Yamanashi

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    Event date: 2022.10

    Language:Japanese   Presentation type:Symposium workshop panel(public)  

    Venue:Kofu City, Yamanashi  

  • 生後6ヶ月までの気象条件と3歳迄のアトピー性 皮膚炎発症リスク:エコチル調査 Major achievement

    横道洋司;篠原亮次;堀内清華;久島萌;小田和早苗;小島令嗣、秋山有佳、大岡忠生、山縣然太朗

    The 81th Annual Meeting of Japanese Society of Public Health  2022.10  Department of Health Sciences, University of Yamanashi

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kofu City, Yamanashi  

  • 1歳時のスクリーンタイムと3歳時の自閉スペクトラム症との関連:エコチル調査より

    久島萌, 小島令嗣, 篠原亮次, 堀内清華, 小田和早苗, 大岡忠生, 秋山有佳, 横道洋司, 山縣然太朗

    The 81th Annual Meeting of Japanese Society of Public Health  2022.10  Department of Health Sciences, University of Yamanashi

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    Venue:Kofu City, Yamanashi  

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  • 青年前期の肥満や痩せ体型を親は正しく認識しているか?

    甲斐大介、芳我ちより、横道洋司、辻京子

    The 81th Annual Meeting of Japanese Society of Public Health  2022.10  Department of Health Sciences, University of Yamanashi

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kofu City, Yamanashi  

  • 山梨県民を対象とした病院勤務医による夜間救急医療相談電話事業の初期検証

    新藤琢磨、横道洋司、山縣然太朗

    The 81th Annual Meeting of Japanese Society of Public Health  2022.10  Department of Health Sciences, University of Yamanashi

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kofu City, Yamanashi  

  • 山梨県民を対象とした病院勤務医による夜間救急医療相談電話事業の初期検証

    新藤琢磨, 横道洋司, 山縣然太朗

    The 81th Annual Meeting of Japanese Society of Public Health  2022.10  Department of Health Sciences, University of Yamanashi

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    Venue:Kofu City, Yamanashi  

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  • 青年前期の肥満や痩せ体型を親は正しく認識しているか?

    甲斐大介, 芳我ちより, 横道洋司, 辻京子

    The 81th Annual Meeting of Japanese Society of Public Health  2022.10  Department of Health Sciences, University of Yamanashi

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    Venue:Kofu City, Yamanashi  

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  • 世帯収入と子どもの3歳時のアレルギー疾患との関連:エコチル調査より

    小島令嗣、篠原亮次、久島萌、堀内清華、小田和早苗、横道洋司、秋山有佳、大岡忠生、山縣然太朗

    The 81th Annual Meeting of Japanese Society of Public Health  2022.10  Department of Health Sciences, University of Yamanashi

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    Event date: 2022.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kofu City, Yamanashi  

  • 世帯収入と子どもの3歳時のアレルギー疾患との関連:エコチル調査より

    小島令嗣, 篠原亮次, 久島萌, 堀内清華, 小田和早苗, 横道洋司, 秋山有佳, 大岡忠生, 山縣然太朗

    The 81th Annual Meeting of Japanese Society of Public Health  2022.10  Department of Health Sciences, University of Yamanashi

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    Venue:Kofu City, Yamanashi  

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  • 小児・思春期1型糖尿病の施設症例数群別のインスリン治療状況の比較検討

    菊池透, 山本幸代, 伊藤善也, 横道洋司, 立川恵美子, 齋藤朋洋, 滝島茂, 後藤元秀, 齋藤玲子, 堀川玲子, 川名宏, 杉原茂孝

    The 65th Annual Meeting of the Japan Diabetes Society  2022.5  神戸大学大学院医学研究科 糖尿病・内分泌内科学

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    Event date: 2022.5

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kobe  

  • 小児1型糖尿病における最近の治療の動向:小児インスリン治療研究会第5コホートの2年間のデータ解析から

    後藤元秀, 山本幸代, 齋藤玲子, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    The 65th Annual Meeting of the Japan Diabetes Society  2022.5  神戸大学大学院医学研究科 糖尿病・内分泌内科学

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    Event date: 2022.5

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kobe  

  • 1959年から 1996 年に発症した小児 期発症 1 型糖尿病児の長期予後 北海道における Population based の調査研究

    松浦信夫, 横道洋司, 伊藤 善也, 鈴木滋, 母坪智行, 望月恵美, 吉岡成人, 北海道内 15 歳未満発症 1 型糖尿病児の長期予後に関する研究班

    The 65th Annual Meeting of the Japan Diabetes Society  2022.5  神戸大学大学院医学研究科 糖尿病・内分泌内科学

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    Event date: 2022.5

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kobe  

  • 小児思春期1型糖尿病初発時における発症年代別の臨床 像の比較~小児インスリン治療研究会第3~5コホート 研究より~

    齋藤玲子, 山本幸代, 後藤元秀, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    第65回日本糖尿病学会年次学術集会  2022.5 

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  • 1959年から1996年に発症した小児期発症1型糖尿病児 の長期予後―北海道におけるPopulation-basedの調査 研究―

    松浦信夫, 横道洋司, 伊藤善也, 母坪智行, 鈴木滋, 吉岡成人

    第65回日本糖尿病学会年次学術集会  2022.5 

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  • 小児1型糖尿病における最近の治療の動向―小児インス リン治療研究会第5コホートの2年間のデータ解析か ら―

    後藤元秀, 山本幸代, 齋藤玲子, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    第65回日本糖尿病学会年次学術集会  2022.5 

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  • 小児・思春期1型糖尿病のインスリン治療の国内地域差 の検討

    川名宏, 山本幸代, 伊藤善也, 横道洋司, 立川恵美子, 齋藤朋洋, 滝島茂, 後藤元秀, 齋藤玲子, 堀川玲子, 菊池透

    第65回日本糖尿病学会年次学術集会  2022.5 

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  • Mother’s iodine exposure and infants’ hypothyroidism: The Japan Environment and Children’s Study Major achievement

    Yokomichi H, Kojima R, Horiuchi S, Ooka T, Akiyama Y, Kushima M, Shinohara R, Yamagata Z

    The 32nd Meeting of the Japan Epidemiological Association  2022.1  Center for Preventive Medical Science, Chiba University

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    Event date: 2022.1

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Tokyo Bay Maihama Hotel First Resort  

  • Mother’s iodine exposure and infants’ hypothyroidism: The Japan Environment and Children’s Study Major achievement

    Yokomichi H, Kojima R, Horiuchi S, Ooka T, Akiyama Y, Kushima M, Shinohara R, Yamagata Z

    The 32th Meeting of the Japan Epidemiological Association  2022.1  Center for Preventive Medical Science, Chiba University

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    Venue:Tokyo Bay Maihama Hotel First Resort  

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  • インフルエンザ感染歴がある小児に対するインフルエンザワクチンの効果:エコチル調査 Major achievement

    横道洋司, 小島令嗣, 堀内清華, 大岡忠生, 秋山有佳, 久島萌, 篠原亮次, 山縣然太朗

    The 80th Annual Meeting of Japanese Society of Public Health  2021.12  Department of Public Health and Health Policy, University of Tokyo

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Shinjuku Ward, Tokyo, Japan  

  • アディポシティリバウンドは思春期の体格を予測する指標となりうるか

    芳我ちより, 横道洋司, 有野久美, 山縣然太朗

    The 80th Annual Meeting of Japanese Society of Public Health  2021.12  Department of Public Health and Health Policy, University of Tokyo

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Shinjuku Ward, Tokyo, Japan  

  • 新型コロナウイルス流行下における子どもの QOL と影響因子:エコチルやまなし追加調査

    堀内 清華, 篠原 亮次, 久島 萌, 小田和 早苗, 由井 秀樹, 大岡 忠生, 小島 令嗣, 秋山 有佳, 横道 洋司, 山縣 然太朗

    The 80th Annual Meeting of Japanese Society of Public Health  2021.12  Department of Public Health and Health Policy, University of Tokyo

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Shinjuku Ward, Tokyo, Japan  

  • 病院勤務医による救急受診相談電話対応の検証

    新藤 琢磨, 横道 洋司, 山縣 然太朗

    The 80th Annual Meeting of Japanese Society of Public Health  2021.12  Department of Public Health and Health Policy, University of Tokyo

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Shinjuku Ward, Tokyo, Japan  

  • 新型コロナウイルス流行下における子どもの孤立感に関係する背景要因の検討

    久島 萌, 堀内 清華, 篠原 亮次, 由井 秀樹, 大岡 忠生, 小島 令嗣, 秋山 有佳, 横道 洋司, 山縣 然太朗, 小田和 早苗

    The 80th Annual Meeting of Japanese Society of Public Health  2021.12  Department of Public Health and Health Policy, University of Tokyo

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    Event date: 2021.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Shinjuku Ward, Tokyo, Japan  

  • 血清総 IgE 値を考慮した母親のアレルギー疾患と早産の関連 エコチル調査より

    小島 令嗣, 横道 洋司, 秋山 有佳, 大岡 忠生, 篠原 亮次, 堀内 清華, 山縣 然太朗

    The 80th Annual Meeting of Japanese Society of Public Health  2021.12  Department of Public Health and Health Policy, University of Tokyo

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    Event date: 2021.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Shinjuku Ward, Tokyo, Japan  

  • 生まれ月と小学生の運動の好き嫌い、スポーツ参加の関連:連続横断研究

    山北 満哉, 安藤 大輔, 佐藤 美理, 秋山 有佳, 横道 洋司, 山縣 然太朗

    The 80th Annual Meeting of Japanese Society of Public Health  2021.12  Department of Public Health and Health Policy, University of Tokyo

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    Event date: 2021.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Shinjuku Ward, Tokyo, Japan  

  • インフルエンザ感染歴がある小児に対するインフルエンザワクチンの効果:エコチル調査 Major achievement

    横道洋司, 小島令嗣, 堀内清華, 大岡忠生, 秋山有佳, 久島萌, 篠原亮次, 山縣然太朗

    The 80th Annual Meeting of Japanese Society of Public Health  2021.12 

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  • Long-term prognosis of child-onset type 1 diabetes in Hokkaido Prefecture Major achievement

    Yokomichi H, Mochizuki M, Suzuki S, Ito Y, Hotsubo T, Matsuura N

    The 54th Annual Scientific Meeting of the Japanese Society for Pediatric Endocrinology  2021.10  Jichi Children's Medical Center Tochigi

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Tokyo  

  • Long-term prognosis of child-onset type 1 diabetes in Hokkaido Prefecture Major achievement

    Yokomichi H, Mochizuki M, Suzuki S, Ito Y, Hotsubo T, Matsuura N

    The 54th Annual Scientific Meeting of the Japanese Society for Pediatric Endocrinology  2021.10  Jichi Children's Medical Center Tochigi

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    Venue:Tokyo   Country:Japan  

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  • A link between date of birth and atopic dermatitis: an analysis by Yamanashi University Invited International conference Major achievement

    Science Japan

    2021.9  Japan Science and Technology Agency

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    Event date: 2021.9

    Language:English   Presentation type:Media report,etc.  

  • A link between date of birth and atopic dermatitis: an analysis by Yamanashi University Invited

    Science Japan

    2021.9  Japan Science and Technology Agency

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    Country:Japan  

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  • 母親のヨードばく露と子どもの甲状腺機能低下症リスクの調査結果を発表-山梨大 Major achievement

    Yokomichi H;Yamagata Z

    QLife Pro  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 母親のヨードばく露と子どもの甲状腺機能低下症 Major achievement

    Yokomichi H;Yamagata Z

    research-er.jp  2021.8 

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    Event date: 2021.8

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • Imputing missing data and multiple imputation Invited Major achievement

    Hiroshi Yokomichi

    Seminar on clinical epidemiologic studies  2021.8  臨床研究連携推進部

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    Event date: 2021.8

    Language:Japanese   Presentation type:Public discourse, seminar, tutorial, course, lecture and others  

    Venue:山梨大学医学部附属病院  

  • Imputing missing data and multiple imputation Invited

    Hiroshi Yokomichi

    Seminar on clinical epidemiologic studies  2021.8  臨床研究連携推進部

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    Language:Japanese   Presentation type:Public discourse, seminar, tutorial, course, lecture and others  

    Venue:山梨大学医学部附属病院  

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  • アトピー性皮膚炎 発症率 出生月で差 山梨大研究 10~12月高く Major achievement

    Yokomichi H;Yamagata Z

    The Yamanashi Nichinichi Shinbun  2021.8 

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    Event date: 2021.8

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 日本の子どものアトピー性皮膚炎、10~12月生まれに発症率「高」の可能性-山梨大 Major achievement

    Yokomichi H;Yamagata Z

    QLife Pro  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 日本の子どものアトピー性皮膚炎、10~12月生まれに発症率「高」の可能性-山梨大

    Yokomichi H, Yamagata Z

    QLife Pro  2021.7 

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    Venue:Japan  

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  • 秋・冬生まれはアトピーのリスク 日本の大規模データで検証 Major achievement

    Yokomichi H;Yamagata Z

    yomiDr.  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 子どもの誕生月とアトピー性皮膚炎発症の関係 山梨大エコチル調査データを解析 Major achievement

    Yokomichi H;Yamagata Z

    The Science News  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 子どもの誕生月とアトピー性皮膚炎発症の関係 山梨大エコチル調査データを解析

    Yokomichi H, Yamagata Z

    The Science News  2021.7 

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    Country:Japan  

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  • 秋・冬生まれはアトピーのリスク Major achievement

    Yokomichi H;Yamagata Z

    JIJI.COM  2021.7  JIJI.COM

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • アトピー性皮膚炎は10~12月生まれが発症率高い、山梨大学が調査 Major achievement

    Yokomichi H;Yamagata Z

    University Journal Online  2021.7  University Journal Online

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • アトピー性皮膚炎は10~12月生まれが発症率高い、山梨大学が調査

    Hiroshi Yokomichi, Zentaro Yamagata

    University Journal Online  2021.7 

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  • 秋・冬生まれはアトピーのリスク

    Yokomichi H, Yamagata Z

    JIJI.COM  2021.7 

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    Country:Japan  

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  • 10~12月生まれの子どもはアトピー性皮膚炎発症率が最も高い―山梨大学が10万人の子どもを対象としたデータを解析 Major achievement

    Yokomichi H;Yamagata Z

    TRUST INFORMATION SPACE  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 10~12月生まれの子どもはアトピー性皮膚炎発症率が最も高い―山梨大学が10万人の子どもを対象としたデータを解析

    Yokomichi H, Yamagata Z

    TRUST INFORMATION SPACE  2021.7 

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    Country:Japan  

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  • 秋・冬生まれはアトピーのリスク 日本の大規模データで検証 Major achievement

    Yokomichi H;Yamagata Z

    Medical Tribune  2021.7  University Journal Online

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • アトピー性皮膚炎の発症 秋~冬生まれの子どもに多く Major achievement

    Yokomichi H;Yamagata Z

    The Education News  2021.7  The Education News

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • アトピー性皮膚炎の発症 秋~冬生まれの子どもに多く

    Yokomichi H, Yamagata Z

    The Education News  2021.7 

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    Country:Japan  

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  • 秋・冬生まれはアトピーのリスク 日本の大規模データで検証

    Hiroshi Yokomichi, Zentaro Yamagata

    Medical Tribune  2021.7 

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    Country:Japan  

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  • 山梨大、エコチル調査でアトピー性皮膚炎は10〜12月生まれが多いことを確認 Major achievement

    Yokomichi H;Yamagata Z

    BIGLOBE news  2021.7  excite

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 山梨大、エコチル調査でアトピー性皮膚炎は10~12月生まれが多いことを確認 Major achievement

    Yokomichi H;Yamagata Z

    Mapion News  2021.7  Mapion

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 山梨大、エコチル調査でアトピー性皮膚炎は10~12月生まれが多いことを確認 Major achievement

    Yokomichi H;Yamagata Z

    excite news  2021.7  excite

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 山梨大、エコチル調査でアトピー性皮膚炎は10~12月生まれが多いことを確認 Major achievement

    Yokomichi H;Yamagata Z

    My Navi News  2021.7  My Navi News

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 10~12月生まれはアトピー発症率高い 山梨大が大規模調査 Major achievement

    Yokomichi H;Yamagata Z

    SankeiBiz  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 10~12月生まれはアトピー発症率高い 山梨大が大規模調査

    Yokomichi H, Yamagata Z

    SankeiBiz  2021.7 

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    Country:Japan  

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  • 山梨大、エコチル調査でアトピー性皮膚炎は10〜12月生まれが多いことを確認

    Yokomichi H, Yamagata Z

    BIGLOBE news  2021.7  excite

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    Venue:Japan  

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  • 山梨大、エコチル調査でアトピー性皮膚炎は10~12月生まれが多いことを確認

    Hiroshi Yokomichi, Zentaro Yamagata

    Mapion News  2021.7  Mapion

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    Country:Japan  

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  • 山梨大、エコチル調査でアトピー性皮膚炎は10~12月生まれが多いことを確認

    Yokomichi H, Yamagata Z

    My Navi News  2021.7 

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    Country:Japan  

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  • 山梨大、エコチル調査でアトピー性皮膚炎は10~12月生まれが多いことを確認

    Hiroshi Yokomichi, Zentaro Yamagata

    excite news  2021.7  excite

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  • 10~12月生まれはアトピーの発症率が高い 山梨大学の調査 Major achievement

    Yokomichi H;Yamagata Z

    livedoor NEWS  2021.7  livedoor NEWS

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 10~12月生まれはアトピー発症率高い 山梨大 Major achievement

    Yokomichi H;Yamagata Z

    Sankei Newspaper  2021.7 

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    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 10~12月生まれはアトピー発症率高い 山梨大 Major achievement

    Yokomichi H;Yamagata Z

    YAHOO News  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 秋冬生まれの子ども アトピー発症率が高い Major achievement

    Yokomichi H;Yamagata Z

    YBS WIDE NEWS  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 10~12月生まれはアトピーの発症率が高い 山梨大学の調査

    Hiroshi Yokomichi, Zentaro Yamagata

    livedoor NEWS  2021.7 

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    Country:Japan  

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  • 秋冬生まれの子ども アトピー発症率が高い

    Yokomichi H, Yamagata Z

    YBS WIDE NEWS  2021.7 

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  • 10~12月生まれはアトピー発症率高い 山梨大

    Hiroshi Yokomichi, Zentaro Yamagata

    Sankei Newspaper  2021.7 

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    Country:Japan  

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  • 10~12月生まれはアトピー発症率高い 山梨大

    Hiroshi Yokomichi, Zentaro Yamagata

    YAHOO News  2021.7 

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  • 山梨大、エコチル調査でアトピー性皮膚炎は10〜12月生まれが多いことを確認

    Yokomichi H, Yamagata Z

    BIGLOBE news  2021.6 

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  • 小児での発症予防を確認 インフルワクチンで調査 Major achievement

    Yokomichi H;Yamagata Z

    日本海新聞  2021.5 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 小児での発症予防を確認 インフルワクチンで調査

    Yokomichi H, Yamagata Z

    日本海新聞  2021.5 

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    Venue:Japan  

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  • 小児での発症予防を確認 インフルワクチンで調査 Major achievement

    Yokomichi H;Yamagata Z

    47 NEWS  2021.5 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 小児での発症予防を確認 インフルワクチンで調査

    47 NEWS

    地方紙と共同通信のよんななニュース  2021.5 

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  • インフルワクチン 小児での発症を予防 山梨大研究チーム発表 Major achievement

    Yokomichi H;Yamagata Z

    秋田さきがけ  2021.5 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 小児1型糖尿病インスリンの治療別・男女別HbA1cの年齢区分内での比較―小児インスリン治療研究会第5コホート登録時データ Major achievement

    齋藤 朋洋, 山本 幸代, 後藤 元秀, 伊藤 善也, 横道 洋司, 滝島 茂, 立川恵美子, 川名 宏, 堀川 玲子, 菊池 透

    The 64th Annual Meeting of the Japan Diabetes Society  2021.5  First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:On website  

  • 本邦での小児1型糖尿病の発症時糖尿病ケトアシドーシスの変遷 ~小児インスリン治療研究会 第3~5コホート研究より~ Major achievement

    立川 恵美子, 滝島 茂, 伊藤 善也, 川名 宏, 後藤 元秀, 山本 幸代, 齋藤 朋洋, 堀川 玲子, 横道 洋司, 松浦 信夫, 佐々木 望, 雨宮 伸, 杉原 茂孝, 菊池 透

    The 64th Annual Meeting of the Japan Diabetes Society  2021.5  First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:On website  

  • 小児1型糖尿病でのインスリン治療の最近の推移:日本小児インスリン治療研究会第5コホート登録時および1年後データの比較 Major achievement

    後藤元秀, 山本幸代, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    The 64th Annual Meeting of the Japan Diabetes Society  2021.5  First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:On website  

  • 小児期発症1型糖尿病糖尿病児の長期予後―北海道におけるPopulation-basedの調査研究― Major achievement

    松浦信夫, 伊藤 善也, 母坪 智行, 横道 洋司, 吉岡 成人, 北海道内15歳未満発症1型糖尿病児の長期予後に関する研究班

    The 64th Annual Meeting of the Japan Diabetes Society  2021.5  First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:On website  

  • 小児1型糖尿病でのインスリン治療の最近の推移:日本小児インスリン治療研究会第5コホート登録時および1年後データの比較

    後藤元秀, 山本幸代, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 川名宏, 菊池透

    The 64th Annual Meeting of the Japan Diabetes Society  2021.5 

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  • 本邦での小児1型糖尿病の発症時糖尿病ケトアシドーシスの変遷 ~小児インスリン治療研究会 第3~5コホート研究より~

    立川 恵美子, 滝島 茂, 伊藤 善也, 川名 宏, 後藤 元秀, 山本 幸代, 齋藤 朋洋, 堀川 玲子, 横道 洋司, 松浦 信夫, 佐々木 望, 雨宮 伸, 杉原 茂孝, 菊池 透

    The 64th Annual Meeting of the Japan Diabetes Society  2021.5 

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  • 小児期発症1型糖尿病糖尿病児の長期予後―北海道におけるPopulation-basedの調査研究―

    松浦信夫, 伊藤 善也, 母坪 智行, 横道 洋司, 吉岡 成人, 北海道内, 歳未満発症, 型糖尿病児の長期予後に関する研究班

    The 64th Annual Meeting of the Japan Diabetes Society  2021.5 

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  • 小児1型糖尿病インスリンの治療別・男女別HbA1cの年齢区分内での比較―小児インスリン治療研究会第5コホート登録時データ

    齋藤 朋洋, 山本 幸代, 後藤 元秀, 伊藤 善也, 横道 洋司, 滝島 茂, 立川恵美子, 川名 宏, 堀川 玲子, 菊池 透

    The 64th Annual Meeting of the Japan Diabetes Society  2021.5 

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  • COVID-19パンデミックによる学校長期休校が小児思春期1型糖尿病の血糖コントロールに与えた影響 Major achievement

    川名宏, 山本幸代, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 後藤元秀, 菊池透

    The 64th Annual Meeting of the Japan Diabetes Society  2021.5  First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama

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    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:On website  

  • COVID-19パンデミックによる学校長期休校が小児思春期1型糖尿病の血糖コントロールに与えた影響

    川名宏, 山本幸代, 伊藤善也, 横道洋司, 齋藤朋洋, 滝島茂, 立川恵美子, 堀川玲子, 後藤元秀, 菊池透

    The 64th Annual Meeting of the Japan Diabetes Society  2021.5 

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  • インフルエンザワクチン 小児でも発症予防を確認 Major achievement

    Yokomichi H;Yamagata Z

    東興日報  2021.5 

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    Venue:Japan  

  • 小児での発症予防を確認 Major achievement

    Yokomichi H;Yamagata Z

    Miyanichi Press  2021.5 

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    Venue:Japan  

  • 小児での発症予防を確認

    Miyanichi Press

    2021.5 

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  • 小児での発症予防確認 インフルワクチンで調査 Major achievement

    Yokomichi H;Yamagata Z

    埼玉新聞  2021.5 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • インフルワクチン 小児の発症2,3割予防 Major achievement

    Yokomichi H;Yamagata Z

    徳島新聞  2021.5 

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    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 小児での発症予防確認 インフルワクチン調査

    Sinin Chuo Shinpo

    2021.5 

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  • インフルワクチンの効果調査 小児の発症2,3割を予防 Major achievement

    Yokomichi H;Yamagata Z

    神戸新聞  2021.5 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 小児での発症予防確認 インフルワクチン調査 Major achievement

    Yokomichi H;Yamagata Z

    Sinin Chuo Shinpo  2021.5 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 子どものインフルエンザ予防接種 2、3割で発症抑える Major achievement

    Yokomichi H;Yamagata Z

    Hokkaido News Pape  2021.5 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 子どものインフルエンザ予防接種 2、3割で発症抑える

    Hokkaido News Pape

    2021.5 

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  • 小児での発症予防確認 インフルワクチン調査

    Yokomichi H, Yamagata Z

    Sinin Chuo Shinpo  2021.5 

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    Venue:Japan  

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  • Influenza vaccine is effective for children aged 1.5 to 3 years of age Major achievement

    Yokomichi H;Yamagata Z

    The Science News  2021.4 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • Influenza vaccine is effective for children aged 1.5 to 3 years of age

    The Science News

    The Science News  2021.4 

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  • 小児での発症予防を確認 インフルワクチンで調査 Major achievement

    Yokomichi H;Yamagata Z

    Muroran Minpo  2021.4 

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    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 小児での発症予防を確認 インフルワクチンで調査

    Muroran Minpo

    2021.4 

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  • 小児での発症予防を確認 インフルワクチンで調査 Major achievement

    Yokomichi H;Yamagata Z

    山口新聞  2021.4 

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    Venue:Japan  

  • 子どもに接種、発症予防確認 インフルワクチン Major achievement

    Yokomichi H;Yamagata Z

    デーリー東北  2021.4 

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    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 小児のインフル接種、発症予防効果は何%? 山梨大チームが研究結果 Major achievement

    Yokomichi H;Yamagata Z

    Kyoto Newspaper  2021.4 

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    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • Influenza vaccine effectiveness for approximately 30% Major achievement

    Yokomichi H;Yamagata Z

    The Yamanashi Nichinichi Shinbun  2021.4 

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    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • Influenza vaccine effectiveness for approximately 30% Invited

    Yokomichi H, Yamagata Z

    The Yamanashi Nichinichi Shinbun  2021.4 

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  • Influenza vaccine effectiveness in children: University of Yamanashi Major achievement

    Yokomichi H;Kojima R;Horiuchi S;Ooka T;Akiyama Y;Miyake K;Mochizuki M;Otawa S;Shinohara R;Yamagata Z;The Japan Environment;Children’s Study Group

    QLife Pro  2021.4 

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    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • Influenza vaccine effectiveness in children: University of Yamanashi

    Yokomichi H, Kojima R, Horiuchi S, Ooka T, Akiyama Y, Miyake K, Mochizuki M, Otawa S, Shinohara R, Yamagata Z, The Japan Environment, Children’s Study Group

    QLife Pro  2021.4 

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    Country:Japan  

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  • New findings of research on dementia Major achievement

    Shinya Midori

    Book  2021.2  Shinchosha

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    Event date: 2021.2

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Tokyo  

  • New findings of research on dementia

    Shinya Midori

    Book  2021.2  Shinchosha

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    Venue:Tokyo  

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  • Predicting future health check-up data by artificial learning Major achievement

    Ooka T, Yokomichi H, Yamagata Z

    The 31th Meeting of the Japan Epidemiological Association  2021.1  Preventive Medicine, Saga University

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    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Saga University  

  • Accelerator measurement and fall in older adults in snowy region Major achievement

    Kojima R, Ukawa S, Yokomichi H, Tanaka A, Kimura N, Amagasa S, Inoue S, Kondo K, Tamakoshi A

    The 31th Meeting of the Japan Epidemiological Association  2021.1  Preventive Medicine, Saga University

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    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Saga University  

  • Accelerator measurement and fall in older adults in snowy region

    Kojima R, Ukawa S, Yokomichi H, Tanaka A, Kimura N, Amagasa S, Inoue S, Kondo K, Tamakoshi A

    The 31th Meeting of the Japan Epidemiological Association  2021.1  Preventive Medicine, Saga University

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    Venue:Saga University  

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  • Predicting future health check-up data by artificial learning

    Ooka T, Yokomichi H, Yamagata Z

    The 31th Meeting of the Japan Epidemiological Association  2021.1  Preventive Medicine, Saga University

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    Venue:Saga University  

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  • 糖尿病性腎症患者でのBMIと死亡率の関係:バイオバンク・ジャパンコホート Major achievement

    横道洋司, 小島令嗣, 堀内清華, 大岡忠生, 山縣然太朗

    The 79th Annual Meeting of Japanese Society of Public Health  2020.10  Department of Healthcare Economics and Quality Management, School of Public Health, Kyoto University

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    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kyoto City, Japan  

  • 中学生におけるインターネット依存とうつの関連:交差遅延モデルによる解析 Major achievement

    小島令嗣, 横道洋司, 秋山有佳, 篠原亮次, 山縣然太朗

    The 79th Annual Meeting of Japanese Society of Public Health  2020.10  Department of Healthcare Economics and Quality Management, School of Public Health, Kyoto University

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    Event date: 2020.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kyoto City, Japan  

  • 中学生におけるインターネット依存とうつの関連:交差遅延モデルによる解析

    小島令嗣, 横道洋司, 秋山有佳, 篠原亮次, 山縣然太朗

    The 79th Annual Meeting of Japanese Society of Public Health  2020.10  Department of Healthcare Economics and Quality Management, School of Public Health, Kyoto University

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    Venue:Kyoto City, Japan  

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  • 糖尿病性腎症患者でのBMIと死亡率の関係:バイオバンク・ジャパンコホート

    横道洋司, 小島令嗣, 堀内清華, 大岡忠生, 山縣然太朗

    The 79th Annual Meeting of Japanese Society of Public Health  2020.10  Department of Healthcare Economics and Quality Management, School of Public Health, Kyoto University

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    Venue:Kyoto City, Japan  

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  • 小児1型糖尿病でのインスリン療法・血糖モニタリングとHbA1cの検討ー日本小児インスリン治療研究会第5コホート登録時データの解析 Major achievement

    後藤元秀, 山本幸代, 伊藤善也, , 横道洋司, 斉藤朋洋, 立川恵美子, 堀川玲子, 菊池透

    The 63rd Annual Meeting of the Japan Diabetes Society  2020.10  Department of Medicine, Division of Diabetology, Endocrinology, and Nephrology

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    Event date: 2020.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:On website  

  • 本邦における小児思春期1型糖尿病・初発時の臨床像~日本小児インスリン治療研究会・第5コホート研究より~ Major achievement

    滝島茂, 立川恵美子, 伊藤善也, 山本幸代, 斉藤朋洋, 堀川玲子, 横道洋司, 松浦信夫, 佐々木望, 雨宮伸, 杉原茂孝, 菊池透

    The 63rd Annual Meeting of the Japan Diabetes Society  2020.10  Department of Medicine, Division of Diabetology, Endocrinology, and Nephrology

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    Event date: 2020.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:On website  

  • 小児1型糖尿病でのインスリン療法・血糖モニタリングとHbA1cの検討ー日本小児インスリン治療研究会第5コホート登録時データの解析

    後藤元秀, 山本幸代, 伊藤善也, 横道洋司, 斉藤朋洋, 立川恵美子, 堀川玲子, 菊池透

    The 63rd Annual Meeting of the Japan Diabetes Society  2020.10 

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  • 本邦における小児思春期1型糖尿病・初発時の臨床像~日本小児インスリン治療研究会・第5コホート研究より~

    滝島茂, 立川恵美子, 伊藤善也, 山本幸代, 斉藤朋洋, 堀川玲子, 横道洋司, 松浦信夫, 佐々木望, 雨宮伸, 杉原茂孝, 菊池透

    The 63rd Annual Meeting of the Japan Diabetes Society  2020.10 

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  • Hospitalisation rate with influenza infection Major achievement

    Mochizuki M, Yokomichi H, Ohta M, Horiuchi S, Kojima R, Yamagata Z, Inukai T

    The 123rd Annual Meeting of the Japan Pediatric Society  2020.4  Department of Pediatrics, Tokushima Univesity

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    Event date: 2020.4

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kobe International Conference Center  

  • Hospitalisation duration with influenza infection Major achievement

    Yokomichi H, Mochizuki M, Kojima R, Horiuchi S, Yamagata Z

    The 123rd Annual Meeting of the Japan Pediatric Society  2020.4  Department of Pediatrics, Tokushima Univesity

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    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kobe International Conference Center  

  • Hospitalisation duration with influenza infection

    Yokomichi H, Mochizuki M, Kojima R, Horiuchi S, Yamagata Z

    The 123rd Annual Meeting of the Japan Pediatric Society  2020.4  Department of Pediatrics, Tokushima Univesity

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    Venue:Kobe International Conference Center  

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  • Hospitalisation rate with influenza infection

    Mochizuki M, Yokomichi H, Ohta M, Horiuchi S, Kojima R, Yamagata Z, Inukai T

    The 123rd Annual Meeting of the Japan Pediatric Society  2020.4  Department of Pediatrics, Tokushima Univesity

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    Venue:Kobe International Conference Center  

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  • Trajectory of internet dependency of Japanese junior high schoolers: focusing on their lifestyles Major achievement

    Kojima R, Yokomichi H, Akiyama Y, Shinohara R, Yamagata Z

    The 30th Meeting of the Japan Epidemiological Association  2020.2  Graduate School of Medicine, Kyoto University

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    Event date: 2020.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kyoto University  

  • Trajectory of internet dependency of Japanese junior high schoolers: focusing on their lifestyles

    Kojima R, Yokomichi H, Akiyama Y, Shinohara R, Yamagata Z

    The 30th Meeting of the Japan Epidemiological Association  2020.2  Graduate School of Medicine, Kyoto University

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    Venue:Kyoto University  

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  • Intestinal bacteria change and inflammatory cytokine in barley intake

    Nishimura M, Hosomi K, Matsuoka T, Goto Y, Paku K, Murakami H, Konishi K, Yokomichi H, Kawashima K, Miyachi M, Mizuguchi K, Yamagata Z, Kunizawa J

    The 30th Annual Scientific Meeting of the Japan Epidemiological Association  2020.2 

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  • Hospitalisation with influenza infection Major achievement

    Yokomichi H, Mochizuki M, Kojima R, Horiuchi S, Yamagata Z

    The 30th Meeting of the Japan Epidemiological Association  2020.2  Graduate School of Medicine, Kyoto University

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    Event date: 2020.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kobe International Conference Center  

  • Hospitalisation with influenza infection

    Yokomichi H, Mochizuki M, Kojima R, Horiuchi S, Yamagata Z

    The 30th Meeting of the Japan Epidemiological Association  2020.2  Graduate School of Medicine, Kyoto University

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    Venue:Kobe International Conference Center  

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  • 予防医療分野における疫学データへの機械学習技術活用について ~スパースモデリングを活用した糖尿病発症予測と予測因子探索~ Invited Major achievement

    大岡 忠生, 日野 英逸, 横道 洋司, 山縣 然太朗

    統計数理研究所・共同利用研究・研究集会 「統計的機械学習の新展開」  2020.1 

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    Event date: 2020.1

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:統計数理研究所  

  • 予防医療分野における疫学データへの機械学習技術活用について ~スパースモデリングを活用した糖尿病発症予測と予測因子探索~ Invited

    大岡 忠生, 日野 英逸, 横道 洋司, 山縣 然太朗

    統計数理研究所・共同利用研究・研究集会 「統計的機械学習の新展開」  2020.1 

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    Venue:統計数理研究所  

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  • 痩せている高齢者 認知症になりやすい Major achievement

    日本老年医学的評価研究機構

    ロハス・メディカル  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 痩せている高齢者 認知症になりやすい

    日本老年医学的評価研究機構

    ロハス・メディカル  2019.12 

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    Venue:Japan  

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  • 認知症を招くー「危ないやせ型」チェックリスト Major achievement

    Kobunsha Co., Ltd.  2019.11 

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    Venue:Japan  

  • 認知症を招くー「危ないやせ型」チェックリスト

    Kobunsha Co., Ltd.  2019.11 

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    Venue:Japan  

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  • 痩せ型の方がリスク Major achievement

    Shinchosha Co., Ltd.  2019.10 

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    Venue:Japan  

  • 痩せ型の方がリスク

    Shinchosha Co., Ltd.  2019.10 

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    Venue:Japan  

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  • 運動習慣と健康QOLとの関連:横断研究 Major achievement

    岡猛, 横道洋司, 山縣然太朗

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kochi City, Japan  

  • 高齢者の食事の適切性の評価法に関する研究~独居高齢者の既存食事調査の再解析~ Major achievement

    Midori Ishikawa, Hiroshi Yokomichi, Tetsuji Yokoyama

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Event date: 2019.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kochi City, Japan  

  • Preventing hospital admission in influenza infection Major achievement

    Hiroshi Yokomichi, Zentaro Yamagata

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Event date: 2019.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kochi City, Japan  

  • 大麦の摂取量と腸内環境との関連:横断研究 Major achievement

    松岡翼, 村上晴香, 横道洋司,宮地元彦,國澤純,山縣然太朗

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kochi City, Japan  

  • Preventing hospital admission in influenza infection

    Hiroshi Yokomichi, Zentaro Yamagata

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Venue:Kochi City, Japan  

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  • 高齢者の食事の適切性の評価法に関する研究~独居高齢者の既存食事調査の再解析~

    Midori Ishikawa, Hiroshi Yokomichi, Tetsuji Yokoyama

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Venue:Kochi City, Japan  

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  • 運動習慣と健康QOLとの関連:横断研究

    岡猛, 横道洋司, 山縣然太朗

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Venue:Kochi City, Japan  

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  • 大麦の摂取量と腸内環境との関連:横断研究

    松岡翼, 村上晴香, 横道洋司, 宮地元彦, 國澤純, 山縣然太朗

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Venue:Kochi City, Japan  

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  • 人工知能技術を活用した2型糖尿病のリスク予測手法の検証と疾患予測因子の探索 Major achievement

    Ooka T, Yokomichi H, Johno H, Nakamoto K, Yoda Y, Yamagata Z

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Event date: 2019.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kochi City, Japan  

  • 1ヶ月間の短時間の運動遊びプログラムは子どもの自制心に影響を及ぼすのか? Major achievement

    山北満哉, 安藤大輔, 杉田勇人, 佐藤美理, 秋山有佳, 山口香, 横道洋司, 山縣然太朗

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:Kochi City, Japan  

  • 1ヶ月間の短時間の運動遊びプログラムは子どもの自制心に影響を及ぼすのか?

    山北満哉, 安藤大輔, 杉田勇人, 佐藤美理, 秋山有佳, 山口香, 横道洋司, 山縣然太朗

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Venue:Kochi City, Japan  

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  • 人工知能技術を活用した2型糖尿病のリスク予測手法の検証と疾患予測因子の探索

    Ooka T, Yokomichi H, Johno H, Nakamoto K, Yoda Y, Yamagata Z

    The 78th Annual Meeting of Japanese Society of Public Health  2019.10  Department of Public Health, School of Medicine, Kochi University

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    Venue:Kochi City, Japan  

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  • わが国の小児思春期1型糖尿病治療の現状~小児インスリン治療研究会第5コホート研究より~ Major achievement

    菊池透, 伊藤善也, 横道洋司, 山本幸代, 望月美恵, 浦上達彦, 川村智行, 菊池信行, 横田一郎, 深見真紀, 井原健二, 志賀健太郎, 竹本幸司, 広瀬正和, 雨宮伸, 杉原茂孝

    53th conference of The Japanese Society for Pediatric Endocrinology  2019.9 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kyoto City, Kyoto  

  • わが国の小児思春期1型糖尿病治療の現状~小児インスリン治療研究会第5コホート研究より~

    菊池透, 伊藤善也, 横道洋司, 山本幸代, 望月美恵, 浦上達彦, 川村智行, 菊池信行, 横田一郎, 深見真紀, 井原健二, 志賀健太郎, 竹本幸司, 広瀬正和, 雨宮伸, 杉原茂孝

    53th conference of The Japanese Society for Pediatric Endocrinology  2019.9  大阪市立総合医療センター 小児代謝・内分泌内科

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kyoto City, Kyoto  

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  • Increase trend in proportion of obesity in Japanese paediatric patients with type 1 diabetes Major achievement

    Mochizuki M, Kikuchi T, Ito Y, Musha I, Anzou M, Matsuo K, Soneda S, Kobayashi K, Yokomichi H, Yokota I, Kawamura T, Kikuchi N, Urakami T, Matsuua N, Sasaki N, Sugihara S, Amemiya S on behalf of The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes

    53th conference of The Japanese Society for Pediatric Endocrinology  2019.9 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kyoto City, Kyoto  

  • Increase trend in proportion of obesity in Japanese paediatric patients with type 1 diabetes

    Mochizuki M, Kikuchi T, Ito Y, Musha I, Anzou M, Matsuo K, Soneda S, Kobayashi K, Yokomichi H, Yokota I, Kawamura T, Kikuchi N, Urakami T, Matsuua N, Sasaki N, Sugihara S, Amemiya S on, behalf of The, Japanese Study Group of, Insulin Therapy for Childhood, Adolescent Diabetes

    53th conference of The Japanese Society for Pediatric Endocrinology  2019.9  大阪市立総合医療センター 小児代謝・内分泌内科

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:Kyoto City, Kyoto  

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  • Dementia incidence by combinations of diabetes, hypertension, dyslipidaemia and body mass index: Japan Gerontological Evaluation Study International conference Major achievement

    Yokomichi H, Kondo K, Nagamine Y, Yamagata Z, Mochizuki M, Kondo N

    55th Annual Meeting of the European Association for the Study of Diabetes  2019.9  European Association for the Study of Diabetes

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    Event date: 2019.9

    Language:English   Presentation type:Poster presentation  

    Venue:Barcelona  

  • Dementia incidence by combinations of diabetes, hypertension, dyslipidaemia and body mass index: Japan Gerontological Evaluation Study International conference

    Yokomichi H, Kondo K, Nagamine Y, Yamagata Z, Mochizuki M, Kondo N

    55th Annual Meeting of the European Association for the Study of Diabetes  2019.9  European Association for the Study of Diabetes

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    Venue:Barcelona  

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  • Increase trend in proportions of overweight and obesity in Japanese paediatric patients with type 1 diabetes International conference Major achievement

    Mochizuki M, Anzo M, Matsuo K, Soneda S, Ito Y, Musha I, Kobayashi K, Yokomichi H, Matsuura N, Sasaki N, Sugihara S, Kikuchi T, Amemiya S, Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes

    55th Annual Meeting of the European Association for the Study of Diabetes  2019.9  European Association for the Study of Diabetes

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation(general)  

    Venue:Barcelona  

  • Increase trend in proportions of overweight and obesity in Japanese paediatric patients with type 1 diabetes International conference

    Mochizuki M, Anzo M, Matsuo K, Soneda S, Ito Y, Musha I, Kobayashi K, Yokomichi H, Matsuura N, Sasaki N, Sugihara S, Kikuchi T, Amemiya S, Japanese Study, Group of, Insulin Therapy for Childhood, Adolescent Diabetes

    55th Annual Meeting of the European Association for the Study of Diabetes  2019.9  European Association for the Study of Diabetes

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    Language:English   Presentation type:Oral presentation(general)  

    Venue:Barcelona  

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  • やせている人ほど認知症になりやすい Major achievement

    Sora Kobayashi

    Kodansha Ltd.  2019.9 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • やせている人ほど認知症になりやすい

    Sora Kobayashi

    Kodansha Ltd.  2019.9 

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    Venue:Japan  

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  • 細身の日本人、認知症なりやすく 欧米人と逆 International conference Major achievement

    The Nikkei (newspaper)  2019.8 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Japan  

  • 細身の日本人、認知症なりやすく 欧米人と逆 International conference

    The Nikkei (newspaper)  2019.8 

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    Venue:Japan  

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  • Diabetes, underweight increase risk of dementia, study finds International conference Major achievement

    Phil Neuffer

    DiabetesPro SmartBrief  2019.7 

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    Event date: 2019.7

    Language:English   Presentation type:Media report,etc.  

    Venue:US  

  • Diabetes, underweight increase risk of dementia, study finds International conference

    Phil Neuffer

    DiabetesPro SmartBrief  2019.7 

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    Venue:US  

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  • High dementia incidence in underweight aged adults: JAGES Cohort International conference Major achievement

    Yohei Tsuruga

    Care Management Online  2019.7 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Tokyo  

  • High dementia incidence in underweight aged adults: JAGES Cohort International conference

    Yohei Tsuruga

    Care Management Online  2019.7 

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    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Tokyo  

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  • Dementia risk by underweight and diabetes in Japanese older adults International conference Major achievement

    Hiroko Kanazawa

    Care Net  2019.6 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Media report,etc.  

    Venue:Tokyo  

  • Dementia risk by underweight and diabetes in Japanese older adults International conference

    Hiroko Kanazawa

    Care Net  2019.6 

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    Venue:Tokyo  

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  • Paper: Dementia risk by combinations of metabolic diseases and body mass index: Japan Gerontological Evaluation Study Cohort Study International conference Major achievement

    ALZFORUM Networking for a cure  2019.6 

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    Event date: 2019.6

    Language:English   Presentation type:Media report,etc.  

    Venue:U.S.A.  

  • Paper: Dementia risk by combinations of metabolic diseases and body mass index: Japan Gerontological Evaluation Study Cohort Study International conference

    ALZFORUM Networking for a cure  2019.6 

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    Venue:U.S.A.  

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  • Probability of dementia diagnosis higher with diabetes, underweight International conference Major achievement

    Phil Neuffer

    Healio Endocrine today  2019.6 

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    Event date: 2019.6

    Language:English   Presentation type:Media report,etc.