Updated on 2024/04/11

写真a

 
Yasutomo Kumakura
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine University Hospital (Medical Team Center) Clinical Assistant Professor
Title
Clinical Assistant Professor
Contact information
メールアドレス

Research History

  • University of Yamanashi   Graduate Faculty of Interdisciplinary Research Faculty of Medicine University Hospital (Medical Team Center)

    2022.2

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    Country：Japan

    Job classification：Associate professor/Lecturer (full time)

  • University of Yamanashi Hospital   center of medical team

    2012.4

  • University of Yamanashi   University Hospital Medical Team Center   assistant professor

    2012.4 - 2022.1

  • University of Yamanashi Hospital   center of medical team

    2012.4

  • 在日本南プレスビテリアンミッション淀川キリスト教病院   ホスピス   専攻医

    2011.4 - 2012.3

  • Osaka University   Hospital Oncology center   Medical Staff

    2010.4 - 2011.3

  • 財団法人山梨厚生会 山梨厚生病院   麻酔科

    2009.7 - 2010.3

  • University of Yamanashi   Graduate Faculty of Interdisciplinary Research Faculty of Medicine Clinical Medicine Science (Anesthesiology)   Medical Staff

    2008.4 - 2009.6

  • University of Yamanashi Hospital   center of postgraduate medical training

    2006.4 - 2008.3

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Education

  • Yamanashi Medical University

    2000.4 - 2006.3

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    Country： Japan

    Course： Master course

  • Yamanashi Medical University   医学部   医学科

    2000.4 - 2006.3

Degree

  • Doctor of Philosophy (medicine) ( 2021.3   University of Yamanashi )

Research Areas

  • Life Science / Anesthesiology

  • Life Science / Anesthesiology

Research Interests

  • Palliative medicine

  • Palliative medicine

Subject of research

  • Palliative medicine

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    2012.04.01

Research Projects

  • がん悪液質によるグリコカリックス破壊と体液貯留の機序の解明

    2022.4 - 2025.3

    若手研究

    熊倉康友

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    Authorship：Principal investigator  Type of fund：：Science research expense

    基礎実験で血管内皮細胞と悪液質誘発ヒト胃癌細胞株の共培養を行い、グリコカリックスの変化と培養液中の構成因子濃度からグリコカリックスの破壊が生じるか検討する。臨床研究としてがん悪液質患者のグリコカリックスのバイオマーカー(シンデカン1・ヘパラン硫酸)の血清濃度測定を行い、経時的変化の評価や体組成分析から得られた体水分量との相関、また生存期間を前向きに調査し、バイオマーカー血清濃度が予後予測因子となるか検討する。

  • Exploring the mechanisms of glycocalyx shedding and fluid retention caused by cancer cachexia

    Grant number：22K16611  2022.4 - 2025.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists  Grant-in-Aid for Early-Career Scientists

  • 脳虚血・還流後のアドレナリン、バゾプレッシンの脳保護効果

    2013.4 - 2017.3

    基盤研究(C)

    浅野伸将

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    Authorship：Coinvestigator(s)  Type of fund：：Science research expense

    アドレナリンとバゾプレッシンは心肺停止時に使用することが推奨されていた。この研究の目的は、アドレナリンとバゾプレッシンが正常な脳血管に与える影響と、脳虚血再灌流後の脳血管に与える影響を調べることである。
    アドレナリンとバゾプレッシンは正常な脳血管に与える影響を認めなかった。アドレナリンはバゾプレッシンとコントロールと比較し、脳虚血再灌流後の脳血管収縮に拮抗する作用を認めた。

  • The Effects of Adrenaline and Vasopressin onPial Microvessels During Global Brain Ischemia-reperfusion Period in Rabbits.

    Grant number：25462401  2013.4 - 2017.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    ASANO Nobumasa, ISHIYAMA Tadahiko, MASAMUNE Taishi, IWASHITA Hironobu, KOTODA Masakazu, IKEMOTO Koudai, KUMAKURA Yasutomo

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    Adrenaline and Vasopressin were recommended to use during cardiopulmonary resuscitation. The aims of the present study were to evaluate the direct effects of adrenaline and vasopressin on cerebral pial arterial diameter changes in the normal states and during ischemia-reperfusion period.
    Adrenaline and Vasopressin exerted no direct action on cerebral pial artery in the normal state. Adrenaline increased cerebral pial arteriolar diameter at compared with vasopressin and control in the ischemia-reperfusion period.

Papers

  • Epidural Hematoma related to lower limb pain and massive liver bleeding in Gorham-Stout disease: A case report. Reviewed

    Yasutomo Kumakura, Norio Hasuda, Kazuki Akita, Tetsuya Iijima, Takashi Matsukawa

    Medicine   102 ( 22 )   e33950   2023.6

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    Authorship：Lead author,　Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    RATIONALE: Gorham-Stout disease (GSD) is a rare disease that causes massive osteolysis and proliferation of abnormal lymphangiomatous tissues. Patients with GSD often experience pain associated with bone fractures and chylothorax. However, bleeding caused by abnormal lymphangiomatous tissue or hematological dysfunction rarely occurs. PATIENT CONCERNS: A 22-year-old female patient with GSD presented with severe left hip and lower limb pain. The GSD had disappeared her right pelvic bone and femur, but no abnormalities were found in the bones at the site of the pain. DIAGNOSES: The patient presented with a chylothorax and cerebrospinal fluid leakage. She was treated with sirolimus and an epidural blood patch, and her symptoms resolved. Computed tomography and magnetic resonance imaging revealed an epidural hematoma extending from L3 to the caudal region, and blood results revealed a consumption coagulopathy. INTERVENTIONS: We presumed that the hematoma caused pain and prescribed pregabalin and morphine. The pain gradually subsided. OUTCOMES: An unexpected liver subcapsular hemorrhage occurred 4 months later, and the patient went into hemorrhagic shock. Transcatheter arterial embolization was promptly performed, and the patient recovered. LESSONS: GSD infrequently causes bleeding related to abnormal lymphangiomatous tissues and coagulopathy, yet it can lead to serious events if it occurs.

    DOI： 10.1097/MD.0000000000033950

    PubMed

  • Amiodarone Provides Long-Lasting Local Anesthesia and Analgesia in Open-State Mouse Nociceptors Reviewed

    Kotoda M, Matsuoka T, Wada K, Jayakar S, Ino H, Kawago K and Kumakura Y

    Frontiers in Pharmacology   2022.3

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    Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

  • Clonazepam for pain due to muscle spasm in a patient with vertebral compression fractures caused by multiple myeloma: a case report. Reviewed

    Kazuki Akita, Yasutomo Kumakura, Emi Nakajima, Hiroki Ishiguro, Tetsuya Iijima

    JA clinical reports   7 ( 1 )   75 - 75   2021.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Vertebral compression fractures can cause severe back pain. Although many types of analgesics and interventional treatments are available, they are sometimes ineffective in mitigating the pain. We encountered a case where clonazepam was effective for the management of severe low back pain caused by lumbar vertebral compression fractures. CASE PRESENTATION: A 44-year-old male was diagnosed with multiple myeloma and had vertebral compression fractures of the first and second lumbar vertebrae. He had been suffering from severe low back pain on movement with muscle spasm and pain-associated anxiety. We considered this breakthrough low back pain to be caused by facet joint pain; thus, we prescribed clonazepam as a muscle relaxant and anxiolytic. Following this treatment, the intractable breakthrough pain was dramatically relieved. CONCLUSION: Clonazepam, which has both muscle relaxant and anxiolytic effects, might be helpful in mitigating pain, associated anxiety, and muscle spasms due to vertebral compression fractures.

    DOI： 10.1186/s40981-021-00477-1

    PubMed

  • Tapentadol Safety and Patient Characteristics Associated with Treatment Discontinuation in Cancer Therapy: A Retrospective Multicentre Study in Japan. Reviewed

    Michihiro Iwaki . Takaomi Kessoku . Taro Kanamori . Kentaro Abe . Nobuhiro Takeno . Ryoko Kawahara . Taisuke Fujimoto . Takashi Igarashi . Yasutomo Kumakura . Naoki Suzuki . Kouhei Kamiya . Naoto Suzuki . Keita Tagami . Tomoya Saeki . Hironori Mawatari . Hiroki Sakurai . Takahiro Higashibata . Takeshi Hirohashi . Atsushi Nakajima . Yasushi Ichikawa . Hiroto Ishiki . Palliative-Care Investigators’ Network in Kanto (PINK)

    Pain and Therapy   2021.9( ISSN：2193-8237 )

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    Language：English   Publishing type：Research paper (scientific journal)  

  • タペンタドールの臨床的特性を把握する後ろ向き多施設共同研究 Reviewed

    岩城 慶大, 結束 貴臣, 金森 太郎, 阿部 健太郎, 竹野 伸洋, 川原 玲子, 藤本 泰輔, 五十嵐 隆志, 熊倉 康友, 鈴木 尚樹, 神谷 浩平, 鈴木 直人, 田上 恵太, 佐伯 朋哉, 馬渡 弘典, 櫻井 宏樹, 東端 孝博, 中島 淳, 市川 靖史, 石木 寛人

    Palliative Care Research   16 ( Suppl. )   S235 - S235   2021.6(  eISSN：1880-5302 )

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(NPO)日本緩和医療学会  

  • Effects of spinal anesthesia and sedation with dexmedetomidine or propofol on cerebral regional oxygen saturation and systemic oxygenation a period after spinal injection. Reviewed Major achievement

    Yasutomo Kumakura, Tadahiko Ishiyama , Toru Matsuoka, Tetsuya Iijima, Takashi Matsukawa

    Journal of Anesthesia   2020.6( ISSN：0913-8668 )

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: To evaluate changes in cerebral regional oxygen saturation (rSO2) after spinal anesthesia and compare the changes in rSO2 and systemic oxygenation between dexmedetomidine sedation and propofol sedation. METHODS: Thirty-six patients scheduled to undergo transurethral surgery under spinal anesthesia were randomly assigned to the dexmedetomidine (n = 18) and propofol groups (n = 18). We used near-infrared spectroscopy sensors to measure rSO2, and obtained data from each side were averaged. After oxygen insufflation, baseline measurements of mean arterial blood pressure (MAP), heart rate, rSO2, pulse oximetry saturation (SpO2), bispectral index, and body temperature were made. After spinal anesthesia, we measured these parameters every 5 min. Twenty minutes after spinal injection, dexmedetomidine or propofol administration was started. We measured each parameter at 10, 25, and 40 min after the administration of dexmedetomidine or propofol. RESULTS: The baseline rSO2 in the dexmedetomidine group was 71.3 ± 7.3%, and that in the propofol group was 71.8 ± 5.6%. After spinal anesthesia, rSO2 in both groups decreased significantly (dexmedetomidine group: 65.4 ± 6.9%; propofol group: 64.3 ± 7.4%). After administering sedatives, rSO2 was equivalent after spinal anesthesia. rSO2 was comparable between the two groups. MAP and SpO2 were significantly higher in the dexmedetomidine group than in the propofol group. CONCLUSION: Spinal anesthesia decreased rSO2; however, the decline was not severe. Dexmedetomidine and propofol did not compromise cerebral oxygenation under spinal anesthesia. Nevertheless, MAP and SpO2 were more stable in dexmedetomidine sedation than in propofol sedation. Dexmedetomidine may be suitable for spinal anesthesia.

    DOI： 10.1007/s00540-020-02816-5

    PubMed

  • A Case of Acute Cholangitis Due to Opioid-induced Dysfunction of Sphincter of Oddi in the Patient with Breast Cancer Reviewed

    Palliative Care Research   15 ( 1 )   29 - 33   2020.2( ISSN：1880-5302 )

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.2512/jspm.15.29

  • Analgesic effects of amiodarone in mouse models of pain Reviewed

    Kotoda Masakazu, Ino Hirofumi, Kumakura Yasutomo, Iijima Tetsuya, Ishiyama Tadahiko, Matsukawa Takashi

    JOURNAL OF PAIN RESEARCH   12   1825 - 1832   2019( ISSN：1178-7090 )

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2147/JPR.S196480

    Web of Science

    PubMed

  • Anesthetic Management of Hardy’s Operation in a Patient with Acromegalic Heart Disease Reviewed

    望月徳光, 熊倉康友, 小口健史, 松川隆

    麻酔   65 ( 9 )   948 - 951   2016.9( ISSN：0021-4892 )

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    J-GLOBAL

  • Patient-controlled epidural analgesia combined with patient-controlled intravenous analgesia for postoperative analgesia after Miles' operation for rectal cancer Reviewed

    Yasutomo Kumakura, Tadahiko Ishiyama, Tetsuya Iijima, Toshiaki Yamaguchi, Takeshi Sugawara, Takeshi Oguchi, Takashi Matsukawa

    Japanese Journal of Anesthesiology   60 ( 8 )   947 - 949   2011.8( ISSN：0021-4892 )

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    A 69-year-old woman (156 cm, 53 kg) underwent a Miles' operation, total hysterectomy, resection of vagina, and thigh flap to vulva for rectal cancer. Before general anesthesia, an epidural catheter was inserted at T11-12 interspace, and 1.5% mepivacaine 7 ml was administered. Sensory block level spread from T4 to L1. Anesthesia was induced with propofol and maintained with sevoflurane in air oxygen mixture. Operation was performed uneventfully. After the operation, postoperative analgesia was achieved with patient-controlled epidural analgesia (PCEA). The epidural solution of 0.06% ropivacaine with 4 μg·ml -1 fentanyl and 20 μg·ml -1 was connected to a PCA pump (i-Fuser, JMS, Japan) that was programmed as an 8 ml initial bolus, 4 ml·hr -1 basal infusion, 2 ml bolus dose, and 10-min lockout interval. Although abdominal pain was well controlled by PCEA, intractable pain in the pelvic nerve region existed. Patient-controlled intravenous analgesia (IV-PCA) with fentanyl, ketamine, and lidocaine was added to PCEA. Then excellent pain relief was obtained without any side effects such as nausea, vomiting, drowsiness, and respiratory depression. It could be useful to use IV-PCA together with PCEA when wide spread postoperative analgesia is necessary.

    Scopus

    PubMed

    J-GLOBAL

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Presentations

  • Hodgkinリンパ腫患者の難治性口腔粘膜炎に対し、ビタミン補充が有効であった一症例 Major achievement

    秋田一樹　熊倉康友

    緩和・支持・心のケア 合同学術大会2020  2020.8 

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    Event date： 2020.8

    Language：Japanese   Presentation type：Poster presentation  

    Venue：オンライン  

  • せん妄と強い苦痛がありながら苦痛緩和のための鎮静を拒否して旅立っていった卵巣がん患者の一例 Major achievement

    熊倉康友

    緩和・支持・心のケア 合同学術大会2020  2020.8 

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    Event date： 2020.8

    Language：Japanese   Presentation type：Poster presentation  

    Venue：オンライン  

  • Hodgkinリンパ腫患者の難治性口腔粘膜炎に対し、ビタミン補充が有効であった一症例

    秋田一樹, 熊倉康友

    緩和・支持・心のケア 合同学術大会2020  2020.8 

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：オンライン  

  • せん妄と強い苦痛がありながら苦痛緩和のための鎮静を拒否して旅立っていった卵巣がん患者の一例

    熊倉康友

    緩和・支持・心のケア 合同学術大会2020  2020.8 

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：オンライン  

  • 大学病院から見た山梨県の緩和ケアの取り組み ～難治性疼痛・副作用への対処など～ Invited

    熊倉 康友

    第22回日本在宅ホスピス協会全国大会 in 山梨  2019.9 

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    Language：Japanese   Presentation type：Public discourse, seminar, tutorial, course, lecture and others  

  • 大学病院での看取り期のケアに向けて~大切な最期のときに~緩和ケア病床から在宅看取りとなった乳がんの1事例を紹介しながら

    熊倉康友

    大学病院の緩和ケアを考える会会誌  2018.9 

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    Language：Japanese   Presentation type：Oral presentation(general)  

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Guidance results

  • 2022

    Type：Achievement of hospital training physicians guidance  Year guidance time：80hours

    Number of people receiving guidance ：6people  (Overseas students)：0people

  • 2021

    Type：Achievement of hospital training physicians guidance  Year guidance time：180hours

    Number of people receiving guidance ：10people  (Overseas students)：0people

  • 2020

    Type：Achievement of hospital training physicians guidance  Year guidance time：180hours

    Number of people receiving guidance ：10people  (Overseas students)：0people

Professional Memberships

  • 日本麻酔科学会

    2007.7

  • 日本緩和医療学会

    2007.1

  • 日本麻酔科学会

  • 日本緩和医療学会