Updated on 2024/04/08

写真a

 
Oguchi Takeshi
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Clinical Medicine (Anesthesiology) Associate Professor
Title
Associate Professor

Degree

  • M.D.,Ph.D ( 1994.9 )

Research Areas

  • Others / Others  / Myocardial ischemia and anesthetics;Protamine and hemodynamics

  • Life Science / Anesthesiology

  • Life Science / Anesthesiology  / 麻酔・蘇生学

Research Interests

  • myocardial ischemia

  • protamine

  • insulin

Subject of research

  • Cardiovascular effects of protamine

  • その他の研究テーマ

  • Preconditioning effects of high dose insulin in the ischemic heart

Research Projects

  • 心筋虚血再灌流障害に対するGLP-1の濃度依存性の心保護作用の解明  Major achievement

    Grant number：23K08356  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    大宮 啓輔, 小口 健史, 松川 隆

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    Authorship：Coinvestigator(s)  Grant type：Competitive  Type of fund：：Science research expense

  • Effects of intranasal insulin administration for acute cerebral inflammation induced by cardiopulmonary bypass  Major achievement

    Grant number：22K08915  2022.4 - 2025.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Coinvestigator(s)  Grant type：Competitive  Type of fund：：Science research expense

  • Cardioprotective effect of lactoferrin via PI3K/Akt pathway against stunned myocardium  Major achievement

    Grant number：21K08965  2021.4 - 2024.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Coinvestigator(s)  Grant type：Competitive  Type of fund：：Science research expense

  • Role of PI3K / Akt pathway on cardioprotective effects of flavonoids against ischemia-reperfusion injury  Major achievement

    Grant number：20K09192  2020.4 - 2024.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Competitive  Type of fund：：Science research expense

  • Insulin preconditioning elevates p-Akt and cardiac contractility after reperfusion in the isolated ischemic rat heart

    Grant number：23592280  2011 - 2013

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    SATO Hiroaki, OGUCHI Takeshi, MATSUKAWA Takashi

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    The optimal timing of insulin institution related to cardiac ischemia was unclear.We tested the hypothesis that insulin administered prior to ischemia provides better cardioprotection than insulin administration after ischemia.
    Hearts isolated from male rats were prepared using Langendorff method and divided into three groups.
    In this study, we concluded insulin administration prior to ischemia provides better cardioprotection than insulin administration only at reperfusion in the isolated ischemic rat heart.

  • THE ROLE OF c-fos IN INDUCING NEUROPATHIC PAIN

    Grant number：13671569  2001 - 2003

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KASHIMOTO Satoshi, SUGAWARA Takeshi, IIJIMA Tetsuya, OGUCHI Takeshi

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    We studied the role of c-fos gene in inducing neuropathic pain. As the model of neuropathic pain, we used partial sciatic nerve injury model, Seltzer model modified by Malmberg et al. (1998) for mice. In this model, Std : ddy mice were demonstrate to show almost the same behavior (thermal and mechanical allodynia) against the noxious stimuli as C57BL6 mice. Schwei et al. reported that, in cancer pain model, astrocytes have undergone a massive hypertrophy in the spinal cord. We studied Malmberg model to evaluate proliferation of astrocytes along with the increase number of c-Fos-positive cells in the spinal cord.

  • The Role of c-fos gene in Neuropathic Pain

    Grant number：11671487  1999 - 2000

    Japan Society for the Promotion of Science  Yamanashi Medical University  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KASHIMOTO Satoshi, IIJIMA Tetuya, OGUCHI Takeshi

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    Malmberg (1998) demonstrated that C57BL6 mice, which received a tight ligature aroud 1/3 to 1/2 of the diameter of the sciatic nerve, can be used as a model of neuropathic pain. We tied the same ligature around the sciatic nerve of Std : ddy mice. The mice, which received the partial sciatic nerve injury, tend to show the threshold changes on thermal and mechanical stimuli.

  • 硬膜外へのフェンタニールを始めとするオピオイド投与による新しい麻酔法の検討

    Grant number：03454372  1991 - 1993

    日本学術振興会  科学研究費助成事業  一般研究(B)

    熊澤 光生, 久米 正記, 田中 行夫, 小口 健史

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    胃亜全摘術を予定されたASA-Iの男性14名
    硬膜外リドカイン投与群(1%リドカイン10ml)…………………L群(7例)
    硬膜外フェンタニール投与群(フェンタニール10μg・kg^<-1>)…F群(7例)
    測定項目:心拍数、血圧、心拍出量・血中エピネフリン、ノルエピネフリンコルチゾール、ヒスタミン〈結果〉両群間で年齢、身長、体重、術中出血量、尿量、輸液量に有意差を認めなかった。血中エピネフリンは、両群ともに麻酔導入前後で平均32ng/lから44ng/lと上昇したが有意差を認めなかった。L群は、硬膜外注入後15分、30分値で注入前に比較し有意な減少を認めた。また注入後90分、120分値で投与前に比較し有意な上昇を認めた。F群は、硬膜外投与後45分(執刀15分)値で69ng/lと注入前に比較し有意な上昇を認めたが、その後安定し120分値まで注入前に比較し有意な上昇を認めなかった。血中ノルエピネフリンは、両群とも麻酔導入前後で平均162ng/lから320ng/lと有意に上昇した。硬膜外注入後L群、F群ともに注入後60分値まで注入前と比較し有意差を認めなかったが、L群では注入後90分、120分値で注入前と比較し有意な上昇を認めた。平均血圧、脈拍は、L群で注入後15分、30分値で有意に低下した。血中コーチゾール、ヒスタミンとも麻酔導入前後、注入前後で両群とも有意差はなかった。
    〈考案〉L群は、血圧、脈拍を有意に減少させ、血中エピネフリン濃度も有意に低下させた。F群は、L群に比較し循環抑制も軽度であった。血中エピネフリン濃度は、L群程には低下、抑制を認めなかったもののその抑制作用は、L群よりも長時間作用した。また血中ヒスタミン濃度は、両群ともに注入前後を通して有意な変動を認めずフェンタニール投与が起因となるヒスタミン遊離による循環動態の変動に影響を与えなかったと思われた。
    〈結語〉硬膜外大量フェンタニール麻酔は、1%リドカイン1回注入法と比較して、循環動態を緩徐に抑制し、かつ長時間手術侵襲による血中カテコラミンの上昇を抑制するため、循環動態の変動が少なく良好な麻酔維持が可能であることが示唆された。

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Papers

  • Safety of intranasal insulin administration in patients undergoing cardiovascular surgery: An open-label, nonrandomized, dose-escalation study Reviewed International coauthorship Major achievement

    Yosuke Nakadate, Akiko Kawakami, Takeshi Oguchi, Keisuke Omiya, Hiroyuki Nakajima, Hiroshi Yokomichi, Hiroaki Sato, Thomas Schricker, Takashi Matsukawa

    JTCVS Open   17   172 - 182   2024.2( ISSN：2666-2736 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.xjon.2023.11.020

  • Role of the protein kinase A signaling pathway and identification of mediators in the cardioprotective effects of enteral lactoferrin for ischemia-reperfusion injury in an isolated rat heart model Reviewed International coauthorship Major achievement

    Keisuke Omiya, Yosuke Nakadate, Hiroaki Sato, Takeshi Oguchi, Toru Matsuoka, Akiko Kawakami, Thomas Schricker, Takashi Matsukawa

    NUTRITION   113   112088 - 112088   2023.9( ISSN：0899-9007 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.nut.2023.112088

  • PI3K/Akt pathway mediates the positive inotropic effects of insulin in Langendorff-perfused rat hearts Reviewed Major achievement

    Yosuke Nakadate, Akiko Kawakami, Hiroaki Sato, Tamaki Sato, Takeshi Oguchi, Keisuke Omiya, Toru Matsuoka, Thomas Schricker, Takashi Matsukawa

    Scientific Reports   12 ( 1 )   2022.12( ISSN：2045-2322  eISSN：2045-2322 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Insulin exerts positive inotropic effects on cardiac muscle; however, the relationship between cardiac contractility and phosphoinositol-3-kinase/Akt (PI3K/Akt) activation remains unclear. We hypothesized that the positive inotropic effects of insulin are dose-dependent and mediated via the PI3K/Akt pathway in isolated normal rat hearts. The Institutional Animal Investigation Committee approved the use of hearts excised from rats under pentobarbital anesthesia. The hearts were perfused at a constant pressure using the Langendorff technique. After stabilization (baseline), the hearts were randomly divided into the following four insulin (Ins) groups: 1) Ins0 (0 IU/L), 2) Ins0.5 (0.5 IU/L), 3) Ins5 (5 IU/L), and 4) Ins50 (50 IU/L) (n = 8 in each group). To clarify the role of the PI3K/Akt pathway in insulin-dependent inotropic effects, we also treated the insulin groups with the PI3K inhibitor wortmannin (InsW): 5) InsW0 (0 IU/L), 6) InsW0.5 (0.5 IU/L), 7) InsW5 (5 IU/L), and 8) InsW50 (50 IU/L). Hearts were perfused with Krebs–Henseleit buffer solution with or without wortmannin for 10 min, followed by 20 min perfusion with the solution containing each concentration of insulin. The data were recorded as the maximum left ventricular derivative of pressure development (LV dP/dt max). Myocardial p-Akt levels were measured at 3 min, 5 min, and at the end of the perfusion. In the Ins groups, LV dP/dt max in Ins5 and Ins50 increased by 14% and 48%, respectively, 3 min after insulin perfusion compared with the baseline. Tachyphylaxis was observed after 10 min in the Ins5 and Ins50 treatment groups. Wortmannin partially inhibited the positive inotropic effect of insulin; although insulin enhanced p-Akt levels at all time points compared with the control group, this increase was suppressed in the presence of wortmannin. The positive inotropic effect of insulin is dose-dependent and consistent with Akt activation. This effect mediated by high doses of insulin on cardiac tissue was temporary and caused tachyphylaxis, potentially triggered by Akt overactivation, which leads beta 1 deactivation.

    DOI： 10.1038/s41598-022-14092-2

    Other Link： https://www.nature.com/articles/s41598-022-14092-2

  • Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium Reviewed Major achievement

    Keisuke Omiya, Yosuke Nakadate, Takeshi Oguchi, Tamaki Sato, Toru Matsuoka, Masako Abe, Akiko Kawakami, Takashi Matsukawa, Hiroaki Sato

    BMC Pharmacology & Toxicology   23 ( 1 )   2022.10( ISSN：2050-6511  eISSN：2050-6511 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Background:

    Lactoferrin, an iron-binding glycoprotein, is known to have protective effects against intestinal and cerebral ischemia-reperfusion (IR) injuries; however, its cardioprotective effects against the stunned myocardium are unknown. This study aimed to test the hypothesis that lactoferrin has cardioprotective effects against stunned myocardium.

    Methods:

    Using isolated rat hearts (Langendorff system), we determined the effects of lactoferrin administered enterally and by direct cardiac perfusion. Rat hearts were perfused using the Langendorff system, and two experiments were performed. In experiment 1, the hearts were divided into the enteral lactoferrin (E-LF) 7.5 m, 15 m, 30 m, and 60 m groups, where lactoferrin (1000 mg/kg) was administered enterally 7.5, 15, 30, and 60 min, respectively, before perfusion; and a control group, where saline was administered 30 min before perfusion. In experiment 2, hearts were allocated to the perfusate lactoferrin (P-LF) 15 and 100 groups, where 15 mg/L and 100 mg/L lactoferrin were respectively added to the perfusate, and a control group. Each group was perfused for 20 min prior to 15 min of no-flow ischemia with pacing, followed by 20 min of reperfusion. The primary outcome was the maximum left ventricular derivative of pressure development (LV dP/dt max) 15 min after reperfusion. Myocardial phospho-protein kinase B (p-Akt) was assayed using western blotting.

    Results:

    The LV dP/dt max 15 min after reperfusion in the E-LF 15 and 30 m groups was significantly higher than that in the control group. However, the effects disappeared in the E-LF 60 m group. In the second experiment, there were no significant differences in LV dP/dt max. Myocardial p-Akt was not significantly activated in any lactoferrin group.

    Conclusion:

    Cardioprotection was observed 15–30 min after enteral lactoferrin but not by direct cardiac perfusion with lactoferrin. Myocardial p-Akt was not associated with the cardioprotective effect. The cardioprotective effect may be induced by enteral lactoferrin-induced substances.

    DOI： 10.1186/s40360-022-00619-w

    Other Link： https://link.springer.com/article/10.1186/s40360-022-00619-w/fulltext.html

  • Anesthetic experience does not reduce accidental dural puncture in surgical patients: a retrospective case-controlled study. Reviewed Major achievement

    Yosuke Nakadate, Emi Nakajima, Kodai Ikemoto, Takeshi Oguchi, Takashi Matsukawa

    BMC Anesthesiology   22 ( 1 )   139 - 139   2022.5( ISSN：1471-2253 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Nature  

    BACKGROUND: Accidental dural puncture (ADP), which is a complication of epidural anesthesia, still exists and leads to worse outcomes in surgical patients. While residency training is important for epidural competency, it remains unknown whether anesthetic experience reduces ADP in surgical patients. Using an incident reporting system along with anesthetic records, this case-controlled study retrospectively investigated risk factors associated with ADP in surgical patients. METHODS: Patients who experienced ADP during epidural anesthesia who were registered in the incident reporting system of our institution between April 2012 and March 2019 were enrolled. Patients with ADP were control-matched with those who without ADP in a 1:3 ratio, to compare the potential risk factors and calculated odds ratios (ORs) for ADP. The primary hypothesis was that anesthesiologists' experience reduces the incidence of ADP. The secondary hypothesis was that there are risk factors for ADP. Between-group differences in anesthesiologists' experience were compared using the Mann-Whitney U test. Significance was set at P < 0.05. RESULTS: Thirty-five patients who experienced ADP were identified from the incident reporting system. These were matched with 69 patients who did not experience ADP. There was no difference in the years of experience of anesthesiologists between the groups that did and did not experience ADP (8 [3-20] vs. 9 [3-18] years, respectively; P = 0.65). CONCLUSIONS: Having an experienced anesthesiologist did not guarantee the prevention of ADP. Daily individual training and briefings would be needed to reduce the incidence of ADP.

    DOI： 10.1186/s12871-022-01657-x

    PubMed

  • Ulinastatin attenuates protamine-induced cardiotoxicity in rats by inhibiting tumor necrosis factor alpha Reviewed Major achievement

    Hisashi Fukushima, Takeshi Oguchi, Hiroaki Sato, Yosuke Nakadate, Tamaki Sato,　Keisuke Omiya, Akiko Kawakami, Toru Matsuoka, Takashi Matsukawa

    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY   394 ( 2 )   373 - 381   2021.2( ISSN：0028-1298 )

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Protamine causes cardiac depression, which may be mediated by tumor necrosis factor alpha (TNF-α). Ulinastatin, a human urinary protease inhibitor, inhibits TNF-α. Here, we aimed to investigate whether ulinastatin prevented protamine-induced myocardial depression by inhibiting TNF-α. Rat hearts were perfused using a Langendorff system, and three protocols were followed. Protocol 1: The hearts were divided into saline, ulinastatin-low, and ulinastatin-high groups. Protamine was administered to each group, and myocardial contractility was the primary outcome. Protocol 2: The hearts were allotted to saline or ulinastatin group. Protamine was administered to each group. TNF-α expression in the coronary effluent and myocardial tissue was measured. Protocol 3: The hearts were allotted to saline and ulinastatin groups. Recombinant rat-TNF-α was administered to each group. Protamine alone reduced the maximum left ventricular pressure derivative (LV dP/dt max) by 45 ± 4%. In contrast, the reduction in LV dP/dt max was 4 ± 3% in the ulinastatin-high group. Compared with that in the saline group, the increase in TNF-α in the coronary effluent was attenuated in the ulinastatin group. Recombinant TNF-α alone reduced LV dP/dt max (- 21 ± 14%). In contrast, when TNF-α was added in the presence of ulinastatin, the decrease in LV dP/dt max was prevented significantly (- 3 ± 8%). We showed, for the first time, that ulinastatin protected against protamine-induced myocardial damage, both by inhibiting TNF-α synthesis and by directly preventing the cardiodepressant action of TNF-α.

    DOI： 10.1007/s00210-020-01983-2

    PubMed

  • Anesthetic Management for Cesarean Section in a Patient with Catecholaminergic Polymorphic Ventricular Tachycardia Reviewed

    　   69 ( 8 )   885 - 888   2020.8( ISSN：0021-4892 )

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Removal methods of rigid stylets to minimise adverse force and tracheal tube movement: a mathematical and in‐vitro analysis in manikins Reviewed Major achievement

    Kotoda M, Oguchi T, Mitsui K, Hishiyama S, Ueda K, Kawakami A, Matsukawa T

    ANAESTHESIA   74 ( 8 )   1041 - 1046   2019.8( ISSN：0003-2409 )

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Delayed-Onset Bilateral Vocal Cord Paralysis After Abdominal Surgery: A Case Report. Reviewed

    Masakazu Kotoda, Takeshi Oguchi, Ayasa Takamino, Keiichi Wada, Takashi Matsukawa

    A&A Practice   10 ( 12 )   316 - 318   2018.6( ISSN：2575-3126 )

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  • Glycemia and the cardioprotective effects of insulin pre-conditioning in the isolated rat heart Reviewed

    Cardiovascular Diabetology   16 ( 1 )   43   2017.4( ISSN：1475-2840 )

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  • Anesthetic Management of Hardy's Operation in a Patient with Acromegalic Heart Disease

    The Japanese journa of anesthesiology   65 ( 9 )   948 - 951   2016.9

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • 特発性頸部内頸動脈血管攣縮患者に対する急性虫垂炎手術の麻酔経験 Reviewed

    大宮　啓輔,池本　剛大,内田　昌子,正宗　大士,小口　健史,松川　隆

    麻酔   64 ( 12 )   1264 - 1268   2015.12

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    Language：Japanese  

  • The Effects of Blood Glucose Concentration on the Shivering Threshold in Rabbits Reviewed Major achievement

    ANESTHESIA AND ANALGESIA   121 ( 2 )   525 - 531   2015.8( ISSN：0003-2999 )

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  • Insulin preconditioning elevates p-Akt and cardiac contractility after reperfusion in the isolated ischemic rat heart. Reviewed Major achievement

    BioMed Research International   2014   1 - 6   2014.8

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  • 術中、著明な低血圧の原因検索に経食道心エコーが有用であった1症例 Reviewed Major achievement

    三井　一葉,正宗　大士,奥山　克巳,小口　健史,古屋　敦司,岩下　博宣,石山　忠彦,松川　隆

    麻酔   62 ( 2 )   204 - 208   2013.2

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  • 周術期の疼痛管理に硬膜外自己調節鎮痛と静脈内自己調節鎮痛を併用した直腸癌の1症例 Reviewed Major achievement

    熊倉　康友,石山　忠彦,飯嶋　哲也,山口　敏昭,菅原　健,小口　健史,松川　隆

    麻酔   60 ( 8 )   947 - 949   2011.8

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  • 片肺換気中にMobitzⅡ型ブロックを呈した1症例 Reviewed Major achievement

    渋谷　和広,石山　忠彦,市川　学,小口　健史,松川　隆

    麻酔   59 ( 3 )   366 - 368   2010.3

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  • レミフェンタニルを用いた全静脈麻酔と硬膜外麻酔の併用で良好に管理しえた筋緊張性ジストロフィ患者の1症例 Reviewed Major achievement

    正宗　大士,大川　岩夫,岩下　博宣,小口　健史,松川　隆

    麻酔   58 ( 5 )   620 - 622   2009.5

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  • The Shivering Threshold in Rabbits with JM-1232(-),a New Benzodiazepine Receptor Agonist Reviewed Major achievement

    正宗　大士,佐藤　宏明,奥山　克巳,今井　祐介,岩下　博宣,石山　忠彦,小口　健史,Daniel I.Sessler,松川　隆

    Anesth Analg   109   96 - 100   2009.2

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  • DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL Reviewed Major achievement

    Doursout MF,Takeshi OGUCHI,Fischer UM,Liang YY,Chelly B,Hartley CJ,Chelly JE

    SHOCK   29 ( 6 )   692 - 702   2008.6

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  • 薬剤関連インシデントとその対策および効果についての検討 Reviewed Major achievement

    木内　理子,石山　忠彦,小口　健史,樫本　温,松川　隆

    日臨麻会誌   27 ( 7 )   728 - 731   2007.7

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  • Effects of 1% Glucose-Containing Ringer`s Solution on Intraoperative Plasma Glucose Concentration in Elderly and Young Patients Reviewed Major achievement

    石山　忠彦,飯嶋　哲也,菅原　健,小口　健史,樫本　温

    循環制御-CIRCULATION CONTROL-   27 ( 3 )   232 - 235   2006.9

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  • Clonidine-ephedrine combination reduces pain on injection of propofol and blunts hemodynamic stress responses during the induction sequence Reviewed Major achievement

    Tadahiko ISHIYAMA,Satoshi KASHIMOTO,Takeshi OGUCHI,Atsushi　FURUYA,Hisashi FUKUSHIMA,Teruo　KUMAZAWA

    Journal of Clinical Anesthesia   18   211 - 215   2006.9

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  • Isoflurane and sevoflurane during reperfusion prevent recovery from ischaemia in mitochondrial KATP channel blocker pretreated hearts Reviewed Major achievement

    Kenichi MASUI,Satoshi KASHIMOTO,Atsushi FURUYA,Takeshi OGUCHI

    European Journal of Anaesthesiology   23 ( 1 )   123 - 129   2006.1

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  • クロニジン、ミダゾラム前投薬の全身麻酔後のシバリング、悪心、嘔吐に与える影響 Reviewed Major achievement

    趙　航,石山　忠彦,小口　健史,熊澤　光生

    麻酔   54 ( 11 )   1253 - 1257   2005.11

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  • Epidural Ropivacaine Anesthesia Decreases the Bispectral Index During the awake Phase and Sevoflurane General Anesthesia Reviewed Major achievement

    Tadahiko ISHIYAMA,Satoshi KASHIMOTO,Takeshi OGUCHI,Toshiaki YAMAGUCHI,Katsumi OKUYAMA,Teruo KUMAZAWA

    ANESTHESIA & ANALGESIA   100 ( 3 )   728 - 732   2005.3

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  • 誌上抄読会「術後急性痛の治療」 Major achievement

    石山　忠彦,飯嶋　哲也,市川　学,古屋　敦司,吉良　聡,三塚　健太郎,長嶺　教光,福島　久史,三谷　茂樹,菅原　健,川村　淳夫,奥山　克巳,山口　敏昭,小口　健史,松川　隆,樫本　温,熊澤　光生

    臨床麻酔   29 ( 1 )   75 - 80   2005.1

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  • Sinus node dysfunction associated with discontinuation of cilostazol in a patient taking atenolol Reviewed Major achievement

    Tadahiko ISHIYAMA,Takeshi OGUCHI,Toshiaki YAMAGUCHI,Teruo KUMAZAWA

    BRITISH JOURNAL OF ANAESTHESIA   93 ( 3 )   472   2004.9

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  • プロポフォール麻酔下の脳腫瘍摘出術中に起きた難治性の全身痙攣 Reviewed Major achievement

    福島　久史,石山　忠彦,小口　健史,増井　健一,松川　隆,熊澤　光生

    麻酔   53 ( 6 )   691 - 692   2004.6

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    Language：Japanese  

  • 質疑応答「人工心肺離脱後の麻酔について」 Major achievement

    熊澤　光生,小口　健史

    臨床麻酔Q&A(I)   16 - 17   2004.5

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    Language：Japanese  

  • Ephedrine, but Not Phenylephrine, Increases Bispectral Index Values During Combined General and Epidural Anesthesia Reviewed Major achievement

    Tadahiko ISHIYAMA,Takeshi OGUCHI,Tetsuya IIJIMA,Takashi MATSUKAWA,Satoshi KASHIMOTO,Teruo KUMAZAWA

    ANESTHESIA AND ANALGESIA   97 ( 3 )   780 - 784   2003.9

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    Language：English  

  • Baroreflex sensitivity and hemodynamic changes in elderly and young patients during propofol anesthesia Reviewed Major achievement

    Tadahiko ISHIYAMA,Takeshi OGUCHI,Teruo KUMAZAWA

    Journal of Anesthesia   17 ( 1 )   65 - 67   2003.2

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    Language：English  

  • Combined spinal and epidural anesthesia for cesarean section in a patient with hypertrophic obstructive cardiomyopathy Reviewed Major achievement

    Tadahiko ISHIYAMA,Takeshi OGUCHI,Tetsuya IIJIMA,Takashi MATSUKAWA,Satoshi KASHIMOTO,Teruo KUMAZAWA

    ANESTHESIA AND ANALGESIA   96 ( 2 )   629 - 630   2003.2

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    Language：English  

  • The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia Reviewed Major achievement

    Tadahiko ISHIYAMA,Satoshi KASHIMOTO,Takeshi OGUCHI,Takashi MATSUKAWA,Teruo KUMAZAWA

    ANESTHESIA AND ANALGESIA   96 ( 1 )   136 - 141   2003.1

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    Language：English  

  • 高血圧ガイドラインは周術期ガイドラインとなりうるか Major achievement

    小口　健史

    臨床麻酔   26 ( 6 )   913 - 919   2002.6

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    Language：Japanese  

  • 硫酸マグネシウムを用いた褐色細胞腫の術中管理 Reviewed Major achievement

    正宗　大士,石山　忠彦,川村　淳夫,鈴木　まほみ,小口　健史,樫本　温,熊澤　光生

    麻酔   51 ( 5 )   516 - 517   2002.5

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    Language：Japanese  

  • Glyburide prevents isoflurane's reducing effects on hydroxyl radical formation in the postischemic reperfused rat heart Reviewed Major achievement

    Toshiaki YAMAGUCHI,Satoshi KASHIMOTO,Takeshi OGUCHI,Teruo KUMAZAWA

    Experimental & Clinical Cardiology   7 ( 1 )   25 - 29   2002.4

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    Language：English  

  • Role of heparin and nitric oxide in the cardiac and regional hemodynamic properties of protamine in conscious chronically instrumented dogs Reviewed Major achievement

    Takeshi OGUCHI,Doursout MF,Satoshi KASHIMOTO,Liang YY,Hartley CJ,Chelly JE

    Anesthesiology   94 ( 6 )   1016 - 1025   2001.6

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    Language：English  

  • Effects of propofol on ischemia and reperfusion in the isolated rat heart compared with thiamylal Reviewed Major achievement

    Fumimasa TAMAKI,Takeshi OGUCHI,Satoshi KASHIMOTO,Akihiko NONAKA,Teruo KUMAZAWA

    Japanese Heart Journal   42 ( 2 )   193 - 206   2001.3

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    Language：English  

  • Sevoflurane reduces dysrhythmias during reperfusion in the working rat heart Reviewed Major achievement

    Takeshi OGUCHI,Satoshi KASHIMOTO,Toshiaki YAMAGUCHI,Kenichi MASUI,Teruo KUMAZAWA

    Journal of Anesthesia   15 ( 1 )   22 - 28   2001.2

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    Language：English  

  • High dose propofol decreases hydroxyl radical formation in the postischemic reperfused heart Reviewed Major achievement

    Satoshi KASHIMOTO,Masaki KUME,Kazumori IKEYA,Takeshi OGUCHI,Teruo KUMAZAWA

    Experimental Clinical Cardiology   5 ( 2 )   65 - 69   2000.2

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    Language：English  

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Books and Other Publications

  • 血管疾患 高血圧症、肺動脈塞栓症、大動脈疾患、抗凝固療法中の症例 Major achievement

    小口　健史（-）

    克誠堂出版株式会社  2011.4 

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    Responsible for pages：387-412-   Language：Japanese  

  • その他の臓器 血尿 Major achievement

    小口　健史（-）

    克誠堂出版株式会社，東京  2001.11 

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    Responsible for pages：136-137-   Language：Japanese  

  • 呼吸の循環への影響ー気道陽圧と低酸素性肺血管収縮についてー Major achievement

    熊澤　光生,小口　健史,石山　忠彦（-）

    日本医療ガス学会，東京  2001.8 

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    Responsible for pages：15-20-   Language：Japanese  

  • Marfan症候群 Major achievement

    小口　健史（-）

    株式会社文光堂，東京  2001.4 

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    Responsible for pages：47-   Language：Japanese  

  • Effects of melatonin on cardiac function and metabolism in the ischemic working rat heart Major achievement

    Kenichi Masui,Takeshi OGUCHI,Satoshi KASHIMOTO　　,Toshiaki YAMAGUCHI,Teruo KUMAZAWA（-）

    Kluwer Academic Publishers  2000.10 

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    Responsible for pages：453-461-   Language：English  

Presentations

  • The Cardioprotective Effects of S-equol for Myocardial Ischemia-Reperfusion Injury is Related to PI3K/Akt Pathway in the Experimental Animal Model International conference

    Mariko Yamada, Yosuke Nakadate, Akiko Kawakami, Keisuke Omiya, Takeshi Oguchi, Tanaka Makoto, Takashi Matsukawa

    Canadian Anesthesiologists’ Society Annual Meeting 2023  2023.6  Canadian Anesthesiologists’ Society

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    Event date： 2023.6

    Language：English   Presentation type：Poster presentation  

    Venue：Quebec City  

  • A Cardiopulmonary Bypass Model in Rats International conference

    Akiko Kawakami, Yosuke Nakadate, Keisuke Omiya, Takeshi Oguchi, Mariko Yamada, Takashi Matsukawa

    Canadian Anesthesiologists’ Society Annual Meeting 2023  2023.6  Canadian Anesthesiologists’ Society

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    Event date： 2023.6

    Language：English   Presentation type：Poster presentation  

    Venue：Quebec City  

  • Pharmacokinetics of Intranasal Insulin Administration During Cardiac Surgery: Dose Escalation Study International conference

    Yosuke Nakadate, Akiko Kawakami, Takeshi Oguchi, Keisuke Omiya, Yokomichi Hiroshi, Hiroyuki Nakajima, Tamaki Sato, Hiroaki Sato, Thomas Schricker, Takashi Matsukawa

    Canadian Anesthesiologists’ Society Annual Meeting 2023  2023.6  Canadian Anesthesiologists’ Society

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    Event date： 2023.6

    Language：English   Presentation type：Poster presentation  

    Venue：Quebec City  

  • Glucose-insulin-normoglycemia therapy decreases surgical site infection following major abdominal surgery: a randomized controlled trial

    2023.6 

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    Event date： 2023.6

    Language：Japanese   Presentation type：Poster presentation  

  • Relationship between intraoperative remifentanil and cerebral regional oxygen saturation in cardiac surgery patients requiring cardiopulmonary bypass

    2023.6 

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    Event date： 2023.6

    Language：Japanese   Presentation type：Poster presentation  

  • Safety Trial of Intranasal Insulin Administration for Cardiac Surgery Patients: Dose Escalation Study

    Yosuke Nakadate, Akiko Kawakami, Takeshi Oguch, Keisuke Omiya, Hiroaki Sato

    American Society of Anesthesiologists Annual Meeting 2022  2022.10 

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    Event date： 2022.10

    Language：English   Presentation type：Poster presentation  

  • 人工心肺を用いる開心術におけるレミフェンタニル使用量と術後IL-6の関係

    中楯 陽介, 川上亜希子, 小口 健史, 松川 隆

    日本麻酔科学会第69回学術集会  2022.10 

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    Event date： 2022.10

    Language：Japanese   Presentation type：Poster presentation  

    Venue：神戸市  

  • Lactoferrin Attenuates Myocardial Ischemia-reperfusion Injury Via Protein Kinase A Pathway International conference

    Keisuke Omiya, Yosuke Nakadate, Hiroaki Sato, Takeshi Oguchi, Tamaki Sato, Toru Matsuoka, Akiko Kawakami, Takashi Matsukawa, Thomas Schricker

    American Society of Anesthesiologists Annual Meeting 2021  2021.10  American Society of Anesthesiologists

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    Event date： 2021.10

    Language：English   Presentation type：Poster presentation  

    Venue：San Diego, CA  

  • Can Experience Reduce Accidental Dural Puncture? International conference

    Yosuke Nakadate, Ayumi Kakemoto, Kodai Ikemoto, Takeshi Oguchi, Takashi Matsukawa

    American Society of Anesthesiologists Annual Meeting 2021  2021.10  American Society of Anesthesiologists

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    Event date： 2021.10

    Language：English   Presentation type：Poster presentation  

    Venue：San Diego, CA  

  • Lactoferrin Attenuates Myocardial Ischemia-reperfusion Injury Via Protein Kinase A Pathway

    Keisuke Omiya, Yosuke Nakadate, Hiroaki Sato, Takeshi Oguchi, Tamaki Sato, Toru Matsuoka, Akiko Kawakami, Takashi Matsukawa, Thomas Schricker

    American Society of Anesthesiologists Annual Meeting 2021  2021.10 

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    Event date： 2021.10

    Language：English   Presentation type：Poster presentation  

  • Airway management of differential lung ventilation for a tracheal stenosis patient caused by large thoracic anterior osteophytes

    Takuya Akiyama, Takeshi Oguchi, Kenta Ueda, Keiichi Wada, Takashi Matsukawa

    The 68th Annual Meeting of the Japanese Society of Anesthesiologists  2021.6 

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    Event date： 2021.6

    Language：English   Presentation type：Oral presentation(general)  

  • 遺伝性血管性浮腫合併患者に対して口腔内手術を2度行った麻酔経験

    森川翔, 建部佐和子, 伊藤賛美, 古藤田眞和, 小口健史, 松川隆

    日本麻酔科学会関東甲信越・東京支部 第59回合同学術集会  2019.9  日本麻酔科学会

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    Event date： 2019.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：東京都新宿  

  • 前置癒着胎盤合併妊婦に対する両側総腸骨バルーン留置下帝王切開をハイブリッド手術室で行った2症例

    森川翔, 三木由理衣, 伊藤賛美, 古藤田眞和, 小口健史, 松川隆

    日本麻酔科学会関東甲信越・東京支部 第59回合同学術集会  2019.9  日本麻酔科学会

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    Event date： 2019.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：東京都新宿  

  • Which amino acids are cardioprotective against ischemia reperfusion injury ? International conference

    Keisuke Omiya, Yosuke Nakadate, Toru Matsuoka, Akiko Kawakami, Hiroaki Sato, Takeshi Oguchi, Takashi Matsukawa

    New Zealand Anaesthesia Annual Scientific Meeting +Annual Queenstown Update in Anaesthesia 2019  2019.8 

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    Event date： 2019.8

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Queenstown, New Zealand  

  • PI3k/Akt経路を介したインスリンの強心作用は濃度依存性か-ラットを用いた孤立心臓モデルにおける検討

    大宮啓輔, 中楯陽介, 松岡徹, 川上亜希子, 小口健史, 松川隆

    日本麻酔科学会第66回学術集会  2019.5  日本麻酔科学会

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    Event date： 2019.5

    Language：Japanese   Presentation type：Poster presentation  

    Venue：兵庫県神戸市  

  • 心臓手術周術期における経鼻インスリン投与後の血糖値への影響

    中楯陽介,川上亜希子, 大宮啓輔, 小口健史, 松川隆, 佐藤宏明

    日本麻酔科学会第66回学術集会  2019.5  日本麻酔科学会

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    Event date： 2019.5

    Language：Japanese   Presentation type：Poster presentation  

    Venue：兵庫県神戸市  

  • PI3k/Akt経路を介したインスリンの強心作用は濃度依存性か―ラットを用いた孤立心臓モデルにおける検討―

    大宮啓輔, 中楯陽介, 松岡徹, 川上亜希子, 小口健史, 松川隆

    日本麻酔科学会学術集会(Web)  2019 

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    Language：Japanese  

  • 心臓手術周術期における経鼻インスリン投与後の血糖値への影響

    中楯陽介, 川上亜希子, 大宮啓輔, 小口健史, 松川隆, 佐藤宏明

    日本麻酔科学会学術集会(Web)  2019 

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    Language：Japanese  

  • Safe Stylet Use During Tracheal Intubation: A Mathematical Analysis and In Vitro Experimental Study International conference Major achievement

    Masakazu Kotoda, Takeshi Oguchi, Kazuha Mitsui, Sohei Hishiyama, Kenta Ueda, Akiko Kawakami

    American Society of Anesthesiologists Annual Meeting 2018  2018.10 

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    Event date： 2018.10

    Language：English   Presentation type：Oral presentation(general)  

  • Safe Stylet Use During Tracheal Intubation: A Mathematical Analysis and In Vitro Experimental Study International conference

    Masakazu Kotoda, Takeshi Oguchi, Kazuha Mitsui, Sohei Hishiyama, Kenta Ueda, Akiko Kawakami

    American Society of Anesthesiologists Annual Meeting 2018  2018.10 

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    Language：English   Presentation type：Oral presentation(general)  

    Venue：San Francisco  

  • 術中気道管理に検討を要したゴーシェ病患者の１症例 Major achievement

    建部 佐和子、深澤 恵莉、内田 昌子、池本 剛大、森川 翔、小口 健史

    関東甲信越・東京支部 第58回合同学術集会  2018.9 

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    Event date： 2018.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：東京都（京王プラザホテル）  

  • 術中気道管理に検討を要したゴーシェ病患者の１症例

    建部 佐和子, 深澤 恵莉, 内田 昌子, 池本 剛大, 森川 翔, 小口 健史

    関東甲信越・東京支部 第58回合同学術集会  2018.9 

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：東京都（京王プラザホテル）  

  • POSITIVE INOTROPIC EFFECTS OF INSULIN: A DOSE-RESPONSE STUDY IN THE ISOLATED RAT HEART International conference Major achievement

    Akiko Kawakami, Hiroaki Sato, Yosuke Nakadate, Takeshi Oguchi

    Canadian Anesthesiologists' Society Annual Meeting 2018  2018.6 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation(general)  

  • POSITIVE INOTROPIC EFFECTS OF INSULIN: A DOSE-RESPONSE STUDY IN THE ISOLATED RAT HEART International conference

    Akiko Kawakami, Hiroaki Sato, Yosuke Nakadate, Takeshi Oguchi

    Canadian Anesthesiologists' Society Annual Meeting 2018  2018.6 

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    Language：English   Presentation type：Oral presentation(general)  

    Venue：CANADA  

  • 再生不良性貧血合併妊娠に対して全身麻酔下に選択的帝王切開術を施行した一例　～麻酔・血小板輸血管理についての考察～ Major achievement

    高三野　彩紗, 池本　剛大,　内田　昌子,　和田　啓一,　小口　健史,　松川　隆

    関東甲信越・東京支部 第57回合同学術集会  2017.9 

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    Event date： 2017.9

    Language：Japanese   Presentation type：Poster presentation  

    Venue：東京都（京王プラザホテル）  

  • Anesthetic management of cesarean section for a patient with CPVT Major achievement

    2016.9 

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    Event date： 2016.9

    Language：Japanese   Presentation type：Oral presentation(general)  

  • The Shivering Threshold in Rabbits on Travelmin&#9415; Induced Major achievement

    American Society of Anesthesiologists Annual Meeting 2015  2015.10 

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    Event date： 2015.10

    Language：English   Presentation type：Oral presentation(general)  

  • High Dose Insulin Elicits Transient Positive Inotropic Effect by Activating the Phosphoinositol-3-kinase/Akt Pathway in the Isolated Rat Heart Major achievement

    American Society of Anesthesiologists Annual Meeting 2015  2015.10 

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    Event date： 2015.10

    Language：English   Presentation type：Oral presentation(general)  

  • High Dose Insulin Elicits Transient Positive Inotropic Effect by Activating the Phosphoinositol-3-kinase/Akt Pathway in the Isolated Rat Heart International conference

    Yosuke Nakadate, Takeshi Oguchi, Akiko Kawakami, Takashi Matsukawa

    American Society of Anesthesiologists Annual Meeting 2015  2015.10 

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    Language：English   Presentation type：Poster presentation  

  • The Shivering Threshold in Rabbits on Travelmin® Induced International conference

    Kenta Ueda, Taishi Masamune, Keiichi Wada, Nobumasa Asano, Takeshi Oguchi, Tadahiko Ishiyama, Takashi Masukawa

    American Society of Anesthesiologists Annual Meeting 2015  2015.10 

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    Language：English   Presentation type：Poster presentation  

  • Morbidity in patients with liver disease:a focus on Child's class B Major achievement

    The 62nd Annual Meeting of the Japanese Society of Anesthesiologists  2015.5 

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    Event date： 2015.5

    Language：Japanese   Presentation type：Oral presentation(general)  

  • Acute Hyperglycemia Diminishes Cardioprotective Effects of High Dose Insulin in the Ischemic Rat Heart International conference

    Yosuke Nakadate, Hiroaki Sato, Takeshi Oguchi, Tamaki Sato, Kazuha Mitsui, Takashi Matsukawa

    American Society of Anesthesiologists Annual Meeting 2014  2014.10 

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    Language：English   Presentation type：Poster presentation  

  • Acute Hyperglycemia Diminishes Cardioprotective Effects of High Dose Insulin in the Ischemic Rat Heart Major achievement

    American Society of Anesthesiologists Annual Meeting 2014  2014.10 

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    Event date： 2014.10

    Language：English   Presentation type：Oral presentation(general)  

  • セボフルラン気化器接合部からの一時的リークが原因と考えられた麻酔回路内酸素濃度低下の 1 例 Major achievement

    鈴木　和博,浅野　伸将,古藤田　眞和,上田　健太,小口　健史,松川　隆

    日本麻酔科学会関東甲信越/東京支部第54回合同学術集会  2014.8 

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    Event date： 2014.8

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京（京王プラザホテル）  

  • 拡張型心筋症様の心不全を呈した先端肥大症患者に対する内視鏡下経鼻的下垂体腫瘍摘出術の麻酔経験 Major achievement

    望月　徳光,熊倉　康友,市川　ゆき子,上田　健太,小口　健史,松川　隆

    日本麻酔科学会関東甲信越/東京支部第54回合同学術集会  2014.8 

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    Event date： 2014.8

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京(京王プラザホテル）  

  • 帝王切開術における脊髄くも膜下麻酔後の硬膜穿刺後頭痛発症例の22%が入院期間を延長する Major achievement

    松岡　徹,中楯　陽介,近藤　聡子,中嶌　絵美,小口　健史,松川　隆

    日本麻酔科学会第61回学術集会  2014.5 

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    Event date： 2014.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：横浜（パシフィコ横浜）  

  • 高血糖は心臓虚血再灌流モデルにおける高用量インスリン投与の心機能回復を減弱する Major achievement

    中楯　陽介,佐藤　宏明,小口　健史,佐藤　環,鈴木　和博,松川　隆

    日本麻酔科学会第61回学術集会  2014.5 

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    Event date： 2014.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：横浜（パシフィコ横浜）  

  • Hyperglycemia Increases the Shivering Threshold in Rabbits. International conference

    Taishi Masamune, Hirofumi Ino, Keiichi Wada, Hiroaki Sato, Masakazu Kotoda, Nobumasa Asano, Takeshi Oguchi, Tadahiko Ishiyama, Daniel I. Sessler, Takashi Matsukawa

    American Society of Anesthesiologists Annual Meeting 2013  2013.10 

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    Language：English   Presentation type：Poster presentation  

  • Cardioprotective effects of preemptive high dose insulin administration in the ischemic isolated rat heart Major achievement

    2013.5 

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    Event date： 2013.5

    Language：Japanese   Presentation type：Oral presentation(general)  

  • Preconditioning Effect of High Dose Insulin in Isolated Rat Heart International conference

    Hisashi Fukushima, Takeshi Oguchi, Tamaki Sato, Hiroaki Sato, Thomas Schricker, Takashi Matsukawa

    American Society of Anesthesiologists Annual Meeting 2012  2012.10 

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    Language：English   Presentation type：Poster presentation  

  • Preconditioning Effect of High Dose Insulin inIsolated Rat Heart Major achievement

    American Society of Anesthesiologists Annual Meeting 2012  2012.10 

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    Event date： 2012.10

    Language：English   Presentation type：Oral presentation(general)  

  • Anesthetic management for cesarean section in parturients with placenta accreta in our hospital Major achievement

    2012.9 

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    Event date： 2012.9

    Language：Japanese   Presentation type：Oral presentation(general)  

  • Effect of Hyperinsulinemic Normoglycemic Clamp on Isolated Rat Heart Major achievement

    American Society of Anesthesiologists Annual Meeting2011  2011.10 

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    Event date： 2011.10

    Language：English   Presentation type：Oral presentation(general)  

  • Effect of Hyperinsulinemic Normoglycemic Clamp on Isolated Rat Heart International conference

    Tamaki Sato, Takeshi Oguchi, Hiroaki Sato, Thomas Schricker, Takashi Matsukawa

    American Society of Anesthesiologists Annual Meeting 2011  2011.10 

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    Language：English   Presentation type：Poster presentation  

  • Ulinastatin, A Protease Inhibitor, Attenuates Protamine-Induced Cardiotoxicity in Rats by Inhibiting Tumor Necrosis Factor Alpha Major achievement

    American Society of Anesthesiologists Annual Meeting2011  2011.10 

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    Event date： 2011.10

    Language：English   Presentation type：Oral presentation(general)  

  • Ulinastatin, A Protease Inhibitor, Attenuates Protamine-Induced Cardiotoxicity in Rats by Inhibiting Tumor Necrosis Factor Alpha International conference

    Hisashi Fukushima, Takeshi Oguchi, Hiroaki Sato, Tamaki Sato, Takashi Matsukawa

    American Society of Anesthesiologists Annual Meeting 2011  2011.10 

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    Language：English   Presentation type：Poster presentation  

  • 特発性三叉神経痛を疑われ、腫瘍・膿瘍が見つかった2症例 Major achievement

    近藤　聡子,寺田　仁秀,中楯　陽介,内田　昌子,小口　健史,松川　隆

    (社)日本麻酔科学会関東甲信越・東京支部第51回学術集会  2011.9 

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    Event date： 2011.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：千葉（幕張メッセ）  

  • Ulinastatin Attenuates Ischemia-Reperfusion Injury in the Isolated Rat Heart Major achievement

    Hisashi FUKUSHIMA,Takeshi OGUCHI,Tadahiko ISHIYAMA,Hiroaki SATO,Takashi MATSUKAWA

    American Society of Anesthesiologists Annual Meeting2010  2010.10 

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    Event date： 2010.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：SAN DIEGO,CALIFORNIA  

  • Ulinastatin Attenuates Ischemia-Reperfusion Injury in the Isolated Rat Heart International conference

    Hisashi Fukushima, Takeshi Oguchi, Tadahiko Ishiyama, Hiroaki Sato, Takashi Matsukawa

    American Society of Anesthesiologists Annual Meeting 2010  2010.10 

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    Language：English   Presentation type：Poster presentation  

  • 4回目の全身麻酔の終了間際に悪性高熱症の発症が疑われた一例 Major achievement

    三井　一葉,池本　剛大,古藤田　眞和,花形　和之,小口　健史,松川　隆

    (社)日本麻酔科学会関東甲信越・東京支部 第50回合同学術集会  2010.9 

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    Event date： 2010.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京（有明TFT）  

  • モルヒネ・ケタミン・リドカイン混合薬を用いた静脈内PCAにより疼痛を管理した食道癌の1例 Major achievement

    中嶌　絵美,飯嶋　哲也,近藤　聡子,寺田　仁秀,奥山　克巳,小口　健史,松川　隆

    第18回甲信疼痛治療研究会  2010.6 

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    Event date： 2010.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：信州大学医学部附属病院（長野県松本市）  

  • ラット摘出心臓標本において,ウリナスタチンは心筋虚血―再灌流障害を軽減する Major achievement

    福島　久史,小口　健史,石山　忠彦,中嶌　絵美,川村　淳夫,松川　隆

    社団法人日本麻酔科学会第57回学術集会  2010.6 

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    Event date： 2010.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：福岡  

  • 山梨大学医学部附属病院におけるコンサルテーション型APSによるPCAを用いた周術期疼痛管理2009年の実績 Major achievement

    飯嶋　哲也,奥山　克巳,石山　忠彦,小口　健史,松川　隆

    社団法人日本麻酔科学会第57回学術集会  2010.6 

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    Event date： 2010.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：福岡  

  • 拡張型心筋症の周術期管理における塩酸ランジオロールの使用経験 Major achievement

    和田啓一,小口　健史,奥山　克巳,浅野伸将,松川　隆,河野　浩二,藤井　秀樹

    山梨麻酔懇話会  2009.12 

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    Event date： 2009.12

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨県中央市  

  • 拡張型心筋症の周術期管理における塩酸ランジオロールの使用経験 Major achievement

    和田啓一,小口　健史,奥山　克巳,浅野伸将,鈴木　まほみ,熊倉　康友,松川　隆

    第42回 甲信麻酔談話会  2009.11 

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    Event date： 2009.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：長野県諏訪市  

  • 大量出血に右心系圧迫が加わり著明な低血圧を来たした縦隔腫瘍の一例 Major achievement

    三井一葉,奥山　克巳,正宗　大士,古屋　敦司,岩下　博宣,石山　忠彦,小口　健史,松川　隆

    第42回 甲信麻酔談話会  2009.11 

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    Event date： 2009.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：長野県諏訪市  

  • TNF-alpha-Induced Cardiotoxicity Is Prevented by Ulinastatin in Isolated Rat Hearts International conference

    Hisashi Fukushima, Takeshi Oguchi, Tadahiko Ishiyama, Satoshi Kashimoto, Takashi Matsukawa

    American Society of Anesthesiologists Annual Meeting 2009  2009.10 

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    Language：English   Presentation type：Poster presentation  

  • TNF-alpha-Induced Cardiotoxicity Is Prevented by Ulinastatin in Isolated Rat Hearts Major achievement

    福島久史,小口　健史,石山　忠彦,樫本温,松川　隆

    American Society of Anesthesiologists Annual Meeting2009  2009.10 

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    Event date： 2009.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：Los Angeles  

  • Anesthetic management of cesarean section in a patient with placenta accrete Major achievement

    2009.8 

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    Event date： 2009.8

    Language：Japanese   Presentation type：Oral presentation(general)  

  • Ulinastatin reduces TNF-alpha induced myocardial dysfunction in the isolated rat heart. Major achievement

    2009.8 

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    Event date： 2009.8

    Language：Japanese   Presentation type：Oral presentation(general)  

  • 静脈内PCAによるfast titrationが奏功した頭頚部癌の一症例 Major achievement

    飯嶋　哲也,熊倉　康友,石渡　小百合,宮里　明芽,奥山　克巳,山口　敏昭,石山　忠彦,小口　健史,松川　隆

    第17回 甲信疼痛治療研究会  2009.6 

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    Event date： 2009.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨県中巨摩郡昭和町  

  • 拡張型心筋症の周術期管理における塩酸ランジオロールの使用経験 Major achievement

    和田　啓一,小口　健史,奥山　克巳,浅野　伸将,松川　隆,河野　浩二,藤井　秀樹

    周術期管理セミナー ー消化器外科手術於いてー  2009.1 

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    Event date： 2009.1

    Language：Japanese   Presentation type：Oral presentation(invited, special)  

    Venue：山梨県中央市（山梨大学医学部）  

  • 大量出血が予測された癒着胎盤合併症妊娠に対する帝王切開術の麻酔経験 Major achievement

    長戸　聡子,浅野　伸将,新谷　則之,小口　健史,石山　忠彦,松川　隆

    第41回 甲信麻酔談話会  2008.11 

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    Event date： 2008.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨県中央市  

  • The Effects of Topical and Intravenous JM1232(-) on Pial Microcirculation in Rabbits Major achievement

    Kazuhiro SHIBUYA,Tadahiko ISHIYAMA,Manabu　ICHIKAWA,Takeshi OGUCHI,Takashi MATSUKAWA

    American Society of Anesthesiologists Annual Meeting2008  2008.10 

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    Event date： 2008.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Orlando  

  • A Novel Sedative Agent,Jm-1232(-),Reduces Dysrhythmias during Reperfusion in Ischemic Rat Hearts. Major achievement

    Takeshi OGUCHI,Hisashi FUKUSHIMA,Tadahiko ISHIYAMA,Ssatoshi　KASHIMOTO,Takashi MATSUKAWA

    American Society of Anesthesiologists Annual Meeting2008  2008.10 

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    Event date： 2008.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Orlando  

  • 周術期の疼痛管理に静脈内PCAと硬膜外PCAを併用した直腸癌の1症例 Major achievement

    熊倉　康友,飯嶋　哲也,山口　敏昭,内田　昌子,菅原　健,小口　健史,松川　隆

    第16回 甲信疼痛治療研究会  2008.6 

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    Event date： 2008.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：長野市松代町  

  • PCAポンプを用いた周術期疼痛管理:山梨大学附属病院における2007年の実績 Major achievement

    飯嶋　哲也,山口　敏昭,石山　忠彦,小口　健史,樫本　温,松川　隆

    日本麻酔科学会第55回学術集会  2008.6 

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    Event date： 2008.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：横浜市(パシフィコ横浜)  

  • 新しい短時間作用性鎮静薬であるJM-1232(-)の心筋虚血-再灌流障害に及ぼす影響-ラット摘出心臓標本を用いて- Major achievement

    福島　久史,小口　健史,山口　敏昭,石山　忠彦,樫本　温,松川　隆

    日本麻酔科学会第55回学術集会  2008.6 

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    Event date： 2008.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：横浜市(パシフィコ横浜)  

  • 新しい短時間作用性鎮静薬であるJM‐1232(-)の心筋虚血‐再灌流障害に及ぼす影響―ラット摘出心臓標本を用いて―

    福島久史, 小口健史, 山口敏昭, 石山忠彦, 樫本温, 松川隆

    Journal of Anesthesia  2008 

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    Language：Japanese  

  • ラット摘出心臓におけるプロタミンの心筋抑制作用と加齢の関係

    小口健史, 石山忠彦, 奥山克巳, 樫本温, 安藤富男, 玉木章雅

    麻酔  2007.11 

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    Language：Japanese  

  • 術後硬膜外PCA中止後にフェンタニルの退薬症候群が疑われた1症例 Major achievement

    中嶌　絵美,飯嶋　哲也,奥山　克巳,山口　敏昭,小口　健史,石山　忠彦,樫本　温,松川　隆

    日本臨床麻酔学会第27回大会  2007.10 

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    Event date： 2007.10

    Language：Japanese   Presentation type：Oral presentation(invited, special)  

    Venue：東京　東京国際フォーラム  

  • 脳内酸素飽和度モニターINVOSで見つけられなかった術中脳梗塞の一例 Major achievement

    浅野　伸将,奥山　克巳,杉原　景子,渋谷　和広,鈴木　まほみ,小口　健史,樫本　温,松川　隆

    第40回甲信麻酔談話会  2007.10 

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    Event date： 2007.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：長野県松本市  

  • Pial Arterial Responses to Brain Ischemia under Sevoflurane or Propofol Anesthesia in Rabbits Major achievement

    Tadahiko ISHIYAMA,Kazuhiro SHIBUYA,Manabu Ichikawa,Takeshi OGUCHI,Takashi MATSUKAWA

    American Society of Anesthesiologists Annual Meeting2007  2007.10 

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    Event date： 2007.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：San Francisco, USA  

  • Protamine-Induced Cardiotoxicity Is Prevented by Ulinastatin in Isolated Rat Hearts Major achievement

    福島　久史,小口　健史,趙　航,樫本　温,松川　隆

    American Society of Anesthesiologists Annual Meeting2007  2007.10 

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    Event date： 2007.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：San Francisco, USA  

  • 術後硬膜外PCA中止後にフェンタニルの退薬症候群が疑われた1症例

    中嶌絵美, 飯嶋哲也, 奥山克巳, 山口敏昭, 小口健史, 石山忠彦, 樫本温, 松川隆

    日本臨床麻酔学会誌  2007.9 

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    Language：Japanese  

  • PCAポンプを用いた周術期疼痛管理:山梨大学附属病院における2006年の実績 Major achievement

    飯嶋　哲也,山口　敏昭,石山　忠彦,小口　健史,樫本　温,松川　隆

    社団法人 日本麻酔科学会 第54回学術集会  2007.6 

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    Event date： 2007.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：北海道札幌市  

  • ラット摘出心臓標本において、ウリナスタチンはプロタミンによる心筋抑制作用を軽減する Major achievement

    福島　久史,小口　健史,山口　敏昭,石山　忠彦,樫本　温,松川　隆

    社団法人 日本麻酔科学会 第54回学術集会  2007.6 

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    Event date： 2007.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：北海道札幌市  

  • ラット摘出心臓標本において,ウリナスタチンはプロタミンによる心筋抑制作用を軽減する

    福島久史, 小口健史, 山口敏昭, 石山忠彦, 樫本温, 松川隆

    Journal of Anesthesia  2007 

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    Language：Japanese  

  • PCAポンプを用いた周術期疼痛管理:山梨大学附属病院における2006年の実績

    飯嶋哲也, 山口敏昭, 石山忠彦, 小口健史, 樫本温, 松川隆

    Journal of Anesthesia  2007 

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    Language：Japanese  

  • 薬剤に関するインシデントとその対策 Major achievement

    木内　理子,石山　忠彦,小口　健史

    第13回 日本麻酔・医事法制(リスクマネジメント)研究会  2006.10 

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    Event date： 2006.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：旭川市民文化会館  

  • 心タンポナーデ解除術中に右室穿孔を起こした一症例 Major achievement

    市川　ゆき子,佐藤　宏明,中嶋　絵美,内田　昌子,小口　健史,松川　隆

    第39回 甲信麻酔談話会  2006.10 

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    Event date： 2006.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨県中巨摩郡昭和町（アピオ甲府）  

  • Temperature-Related Changes in Myocardial Dysfunction Induced by Protamine in Isolated Rat Hearts Major achievement

    Takeshi OGUCHI,Satoshi KASHIMOTO,Tadahiko ISHIYAMA,Hisashi FUKUSHIMA,Tomio ANDOH

    AMERICAN SOCIETY OF ANESTHESIOKOGISTS Annual Meeting2006  2006.10 

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    Event date： 2006.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Chicago　America  

  • 電動式PCAポンプの問題点とその解決策:理想のPCAポンプを求めて Major achievement

    飯嶋　哲也,石山　忠彦,小口　健史,山口　敏昭,松川　隆,樫本　温

    (社)日本麻酔学会 東京・関東甲信越支部 第46回合同学術集会  2006.9 

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    Event date： 2006.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京新宿区  

  • Patient-Controlled Epidural Analgesia in the Elderly and Young Patients after Major Thoracic or Abdominal Surgery Major achievement

    Tadahiko ISHIYAMA,Tetsuya IIJIMA,Takeshi OGUCHI,Katsumi OKUYAMA,Satoshi KASHIMOTO

    ASA Annual Meeting 2005  2005.10 

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    Event date： 2005.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Atlanta,America  

  • Aging Does Not Modulate Myocardial Dysfunction Induced by Protamine in the Lsolated Rat Hearts. Major achievement

    Takeshi OGUCHI,Tadahiko ISHIYAMA,Zhao HANG,Akihiro Sato,Satoshi KASHIMOTO

    ASA Annual Meeting 2005  2005.10 

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    Event date： 2005.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Atlanta,America  

  • ラット摘出心臓におけるプロタミンの心筋抑制作用と加齢の関係 Major achievement

    小口　健史,石山　忠彦,奥山　克巳,樫本　温,玉木　章雅

    (社)日本麻酔科学会 東京・関東甲信越支部 第45回合同学術集会  2005.9 

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    Event date： 2005.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京都港区  

  • 自己調節鎮痛法(Patient Controlled Analgesia)の有用性の検討 Major achievement

    石山　忠彦,飯嶋　哲也,小口　健史,熊澤　光生

    第17回日本老年麻酔学会  2005.3 

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    Event date： 2005.3

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：石川県金沢市  

  • 麻酔導入中に突然Vfを来した一症例 Major achievement

    朝田　嘉一,奥山　克巳,小口　健史

    第37回甲信麻酔談話会  2004.11 

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    Event date： 2004.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨県甲府市  

  • Age-Related Changes in the Cardioprotective Effect of Ischemic Preconditioning in the Isolated Rat Hearts: Role of Intracellular Major achievement

    Takeshi OGUCHI,Satoshi KASHIMOTO,Tadahiko ISHIYAMA,Kenichi MASUI,Teruo KUMAZAWA

    2004 American Society of Anesthesiologists Annual Meeting  2004.10 

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    Event date： 2004.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Las Vegas Convention Center, Las Vegas, Nevada  

  • ランジオロール投与中心停止を来した1症例 Major achievement

    石山　忠彦,小口　健史,山口　敏昭,熊澤　光生

    日本蘇生学会第23回大会  2004.9 

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    Event date： 2004.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪府大阪市  

  • 全身麻酔導入後の経食道心エコーにて閉塞性肥大型心筋症と診断された一症例 Major achievement

    長嶺　教光,奥山　克巳,川崎　晋睦,小口　健史,樫本　温,石山　忠彦,熊澤　光生

    第25回日本循環制御医学会総会  2004.6 

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    Event date： 2004.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：北海道函館市  

  • 副腎白質ジストロフィー患者の麻酔経験 Major achievement

    長嶺　教光,石山　忠彦,小口　健史,奥山　克巳,熊澤　光生

    社)日本麻酔科学会第51回学術集会  2004.5 

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    Event date： 2004.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：愛知県名古屋市  

  • 全身麻酔導入後の経食道心エコーにて閉塞性肥大型心筋症と診断された一症例

    長嶺 教光, 奥山 克巳, 川崎 晋睦, 小口 健史, 樫本 温, 石山 忠彦, 熊澤 光生

    循環制御  2004.4 

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    Language：Japanese  

  • 高齢者と若年者での1%ブドウ糖含有酢酸リンゲル液(フィジオ140)投与時の術中血糖の変化 Major achievement

    石山　忠彦,小口　健史,熊澤　光生

    第16回日本老年麻酔学会  2004.1 

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    Event date： 2004.1

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：鳥取県米子市  

  • 帝王切開術後における鎮痛法の検討-山梨大学医学部附属病院における2002年の実績- Major achievement

    今井　洋史,飯嶋　哲也,山口　敏昭,奥山　克巳,内田　昌子,石山　忠彦,小口　健史,松川　隆,樫本　温,熊澤　光生

    第16回日本局所麻酔学会  2003.12 

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    Event date： 2003.12

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪府豊中市  

  • Free radical scavenger with inhalation anesthetic prevents recovery from ischemia in rat hearts Major achievement

    Kenichi MASUI,Satoshi KASHIMOTO,Atsushi FURUYA,Takeshi OGUCHI,Teruo KUMAZAWA

    International Society for Heart Research(ISHR) The 20th Annual Meeting of the Japanese Section  2003.11 

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    Event date： 2003.11

    Language：English   Presentation type：Oral presentation(general)  

    Venue：東京都港区  

  • 閉塞性動脈硬化症患者の下肢血行再建術中に心停止を来した1症例 Major achievement

    石山　忠彦,?橋　邦仁,山口　敏昭,小口　健史,熊澤　光生

    日本蘇生学会第22回大会  2003.11 

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    Event date： 2003.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：長野県長野市  

  • 気管切開孔よりブロッカーチューブを用いて分離肺換気を行った一例 Major achievement

    今井　洋史,小口　健史,古屋　敦司,増井　健一,木内　理子,鈴木　まほみ

    第36回甲信麻酔談話会  2003.11 

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    Event date： 2003.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：長野県松本市  

  • Inhalation Anesthetics during Reperfusion Prevent Recovery from Ischemia in the Mitochondrial KATP Channel Blocker Pretreated Hearts Major achievement

    Kenichi MASUI,Satoshi KASHIMOTO,Atsushi FURUYA,Takeshi OGUCHI,Teruo KUMAZAWA

    2003 American Society of Anesthesiologists Annual Meeting  2003.10 

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    Event date： 2003.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：San Francisco, California  

  • クロニジン前投薬と、エフェドリンの先行静注は、プロポフォ-ル静注時の血管痛を軽減する Major achievement

    石山　忠彦,小口　健史,川村　淳夫,飯嶋　哲也,熊澤　光生

    日本臨床麻酔学会第23回大会  2003.10 

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    Event date： 2003.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山口県下関市  

  • Aging Reduces the Cardioprotective Effect of Isoflurane-Induced Preconditioning in the Isolated Rat Hearts Major achievement

    Takeshi OGUCHI,Satoshi KASHIMOTO,Kenichi MASUI,Tadahiko ISHIYAMA,Teruo KUMAZAWA

    2003 American Society of Anesthesiologists Annual Meeting  2003.10 

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    Event date： 2003.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：San Francisco, California  

  • クロニジン前投薬と,エフェドリンの先行静注は,プロポフォール静注時の血管痛を軽減する

    石山忠彦, 小口健史, 川村淳夫, 飯嶋哲也, 熊沢光生

    日本臨床麻酔学会誌  2003.9 

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    Language：Japanese  

  • 各種PCAポンプの問題点とその解決策:理想のPCAポンプを求めて Major achievement

    飯嶋　哲也,山口　敏昭,奥山　克巳,石山　忠彦,小口　健史,松川　隆,樫本　温,熊澤　光生

    日本麻酔科学会東京・関東甲信越支部第43回合同学術集会  2003.9 

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    Event date： 2003.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京都大田区  

  • 塩酸ランジオロールとニカルジピンを用いた腹腔鏡下褐色細胞腫摘出術の術中管理 Major achievement

    長嶺　教光,小口　健史,石山　忠彦,奥山　克巳,樫本　温,熊澤　光生

    第24回日本循環制御医学会総会  2003.5 

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    Event date： 2003.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪府豊中市  

  • PCAポンプを用いた周術期鎮痛:山梨大学医学部附属病院における2002年の実績 Major achievement

    飯嶋　哲也,山口　敏昭,小口　健史,松川　隆,樫本　温,熊澤　光生

    日本麻酔科学会第50回学術集会  2003.5 

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    Event date： 2003.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：神奈川県横浜市  

  • 塩酸ランジオロールとニカルジピンを用いた腹腔鏡下褐色細胞腫摘出術の術中管理

    長嶺 教光, 小口 健史, 石山 忠彦, 奥山 克巳, 樫本 温, 熊澤 光生

    循環制御  2003.5 

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    Language：Japanese  

  • 塩酸ランジオロールとニカルジピンを用いた腹腔鏡下褐色細胞腫摘出術の術中管理 Major achievement

    長嶺　教光,小口　健史,石山　忠彦,奥山　克巳,熊澤　光生

    第2回山梨麻酔懇話会  2003.4 

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    Event date： 2003.4

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨県中巨摩郡  

  • クロニジン、ミダゾラム前投薬の術後のシバリングに与える影響 Major achievement

    趙　航,石山　忠彦,小口　健史,熊澤　光生

    第15回日本老年麻酔学会  2003.1 

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    Event date： 2003.1

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：岩手県盛岡市  

  • クロニジン、ミダゾラム前投薬の術後の悪心、嘔吐に与える影響 Major achievement

    石山　忠彦,趙　航,小口　健史,熊澤　光生

    第15回日本老年麻酔学会  2003.1 

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    Event date： 2003.1

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：岩手県盛岡市  

  • 極小未熟児における動脈管開存症根治術の麻酔経験 Major achievement

    野中　明彦,鈴木　聡美,佐藤　宏明,渋谷　和広,阿部　文明,奥山　克巳,小口　健史

    第35回甲信麻酔談話会  2002.11 

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    Event date： 2002.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨県甲府市  

  • 気管支ブロッカーチューブの使用経験 Major achievement

    長嶺　教光,福島　久史,奥山　克巳,小口　健史

    第35回甲信麻酔談話会  2002.11 

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    Event date： 2002.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨県甲府市  

  • プロポフォール麻酔下での脳腫瘍摘出術中に頻回の痙攣発作を来した一症例 Major achievement

    福島　久史,石山　忠彦,小口　健史,増井　健一,樫本　温,熊澤　光生,杉田　正夫

    日本麻酔科学会関東甲信越地方会第42回大会  2002.9 

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    Event date： 2002.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：長野県松本市  

  • ラット摘出心臓におけるプロタミンの心収縮抑制作用に対するヘパリンの役割 Major achievement

    小口　健史,玉木　章雅,樫本　温,石山　忠彦,熊澤　光生

    第23回日本循環制御医学会総会  2002.5 

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    Event date： 2002.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：神奈川県横浜市  

  • ラット摘出心臓におけるプロタミンの心収縮抑制作用に対するヘパリンの役割

    小口 健史, 玉木 章雅, 樫本 温, 石山 忠彦, 熊澤 光生

    循環制御  2002.5 

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    Language：Japanese  

  • クロニジン前投薬のプロポフォール麻酔下でのエフェドリンの作用に及ぼす影響ー高齢者と若年者での違いー Major achievement

    山口　敏昭,石山　忠彦,小口　健史,樫本　温,熊澤　光生

    日本麻酔科学会第49回大会  2002.4 

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    Event date： 2002.4

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：福岡県福岡市  

  • 高齢者において、硬膜外ロピバカインは、全身麻酔中のBIS値を低下させる Major achievement

    石山　忠彦,小口　健史,岩下　博宣,熊澤　光生

    第14回日本老年麻酔学会  2002.2 

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    Event date： 2002.2

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：宮崎県宮崎市  

  • 閉塞性肥大型心筋症合併妊婦の帝王切開術に対する、脊椎麻酔、硬膜外麻酔併用による麻酔経験 Major achievement

    石山　忠彦,小口　健史,飯嶋　哲也,熊澤　光生

    第14回日本局所麻酔学会  2001.11 

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    Event date： 2001.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京  

  • 多重人格患者の2症例に対する麻酔管理 Major achievement

    寺田　仁秀,山口　敏昭,奥山　克巳,小口　健史,松川　隆,熊澤　光生

    日本臨床麻酔学会第21回大会学術集会・総会  2001.10 

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    Event date： 2001.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：横浜  

  • Effects of clonidine premedication on the pressor response to ephedrine in elderly and young patients during propofol anesthesia Major achievement

    Tadahiko ISHIYAMA,Takeshi OGUCHI,Satoshi KASHIMOTO,Teruo KUMAZAWA

    American Society of Anesthesiologists 2001 Annual Meeting  2001.10 

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    Event date： 2001.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：New Orleans  

  • Heparin modulates myocardial dysfunction induced by protamine in isolated rat hearts. Major achievement

    Takeshi OGUCHI,Fumimasa TAMAKI,Satoshi KASHIMOTO,Tadahiko ISHIYAMA,Kenichi MASUI

    American Society of Anesthesiologists 2001 Annual Meeting  2001.10 

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    Event date： 2001.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：New Orleans  

  • Propofol with new effect compartment-controlled target-controlled infusion algorithm induces minimal hemodynamic changes after tracheal intubation. Major achievement

    Kenichi MASUI,Tadahiko ISHIYAMA,Satoshi KASHIMOTO,Takeshi OGUCHI,Teruo KUMAZAWA

    American Society of Anesthesiologists 2001 Annual Meeting  2001.10 

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    Event date： 2001.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：New Orleans  

  • シンポジウム:高血圧患者の麻酔管理「高血圧症患者の術中管理」 Major achievement

    小口　健史

    日本臨床麻酔学会第21回大会学術集会・総会  2001.10 

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    Event date： 2001.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：横浜  

  • 多重人格患者の2症例に対する麻酔管理

    寺田仁秀, 山口敏昭, 奥山克巳, 小口健史, 松川隆, 熊沢光生

    日本臨床麻酔学会誌  2001.9 

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    Language：Japanese  

  • 高血圧症患者の術中管理

    小口健史

    日本臨床麻酔学会誌  2001.9 

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    Language：Japanese  

  • 第V凝固因子低下症患者に対し、脊椎麻酔を施行した一例 Major achievement

    三谷　茂樹,石山　忠彦,小口　健史,熊澤　光生

    第41回日本麻酔科学会関東甲信越地方会  2001.9 

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    Event date： 2001.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：埼玉  

  • 硬膜外カテーテル挿入による硬膜外血腫が疑われた一例 Major achievement

    福島　久史,小口　健史

    第34回甲信麻酔談話会  2001.9 

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    Event date： 2001.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：長野  

  • 術中覚醒既往の疑われた患者に対しBISを用いて麻酔管理を行った一症例 Major achievement

    三浦　志啓,石山　忠彦,山口　敏昭,小口　健史,樫本　温,熊澤　光生

    第41回日本麻酔科学会関東甲信越地方会  2001.9 

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    Event date： 2001.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：埼玉  

  • 高血圧患者の麻酔管理 高血圧患者の周術期管理のスタンダード作りを目指して 高血圧症患者の術中管理

    小口 健史

    日本臨床麻酔学会誌  2001.9 

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    Language：Japanese  

  • 大学病院における薬剤部調剤による術後硬膜外PCAの導入 Major achievement

    飯嶋　哲也,山口　敏昭,奥山　克巳,寺田　仁秀,石山　忠彦,小口　健史,松川　隆,樫本　温,熊澤　光生

    日本ペインクリニック学会第35回大会  2001.7 

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    Event date： 2001.7

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：岐阜  

  • 大学病院における術後硬膜外PCA導入時の看護婦・薬剤師に対するアンケート調査 Major achievement

    飯嶋　哲也,内田　昌子,小口　健史,石山　忠彦,樫本　温,熊澤　光生

    第9回甲信疼痛治療研究会  2001.6 

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    Event date： 2001.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨  

  • クロニジン、ミダゾラム前投薬の、麻酔導入時のプロポフォールによる低血圧に対する影響ー高齢者と若年者での違いー Major achievement

    石山　忠彦,小口　健史,山口　敏昭,樫本　温,熊澤　光生

    日本麻酔科学会第48回大会  2001.4 

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    Event date： 2001.4

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：神戸  

  • クロニジン、ミダゾラム前投薬時の、エフェドリンに対する反応性ー高齢者と若年者における反応性の違いー Major achievement

    石山　忠彦,小口　健史,熊澤　光生

    第13回日本老年麻酔学会  2001.1 

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    Event date： 2001.1

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：高知  

  • Effects of nicorandil on myocardial function and metabolism in the ischemic heart with or without inhalation anesthetics Major achievement

    Atsushi FURUYA,Satoshi KASHIMOTO,Takeshi OGUCHI,Ken-ichi MASUI,Teruo KUMAZAWA

    American Society of Anesthesiologists 2000 Annual Meeting  2000.10 

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    Event date： 2000.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：San Francisco, California  

  • 当院における術中照射の管理について Major achievement

    三谷　茂樹,三浦　志啓,松川　隆,小口　健史

    第33回甲信麻酔談話会  2000.10 

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    Event date： 2000.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨  

  • 山梨県立あけぼの医療福祉センターにおける心身障害者歯科治療の全身麻酔症例の検討 Major achievement

    川村　淳夫,奥山　克巳,山口　敏昭,小口　健史,樫本　温,熊澤　光生

    日本臨床麻酔学会第20回大会  2000.10 

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    Event date： 2000.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：佐賀  

  • 無痙攣通電療法における血液透析患者の麻酔 Major achievement

    玉木　章雅,野中　明彦,山口　敏昭,古屋　敦司,奥山　克巳,小口　健史,熊澤　光生

    日本臨床麻酔学会第20回大会  2000.10 

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    Event date： 2000.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：佐賀  

  • Age-related propofol effects on myocardial contraction and intracellular Ca2 dynamics of isolated rat hearts Major achievement

    Takeshi OGUCHI,Toshiaki YAMAGUCHI,Satoshi KASHIMOTO,Atsushi FURUYA,Ken-ichi MASUI

    American Society of Anesthesiologists 2000 Annual Meeting  2000.10 

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    Event date： 2000.10

    Language：English   Presentation type：Oral presentation(general)  

    Venue：San Francisco, California  

  • 山梨県立あけぼの医療福祉センターにおける心身障害者歯科治療の全身麻酔症例の検討

    川村淳夫, 奥山克巳, 山口敏昭, 小口健史, 樫本温, 熊沢光生

    日本臨床麻酔学会誌  2000.9 

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    Language：Japanese  

  • 無けいれん通電療法における血液透析患者の麻酔

    玉木章雅, 野中明彦, 山口敏昭, 古屋敦司, 奥山克巳, 小口健史, 熊沢光生

    日本臨床麻酔学会誌  2000.9 

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    Language：Japanese  

  • 肺高血圧症を合併した慢性肺動脈血栓塞栓症に対する血栓内膜摘除術の麻酔経験 Major achievement

    川村　淳夫,奥山　克巳,石山　忠彦,山口　敏昭,小口　健史,松川　隆,樫本　温,熊澤　光生

    第5回日本心臓血管麻酔学会学術大会・総会  2000.9 

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    Event date： 2000.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪  

  • 無痙攣通電療法における血液透析患者の麻酔

    玉木 章雅, 野中 明彦, 山口 敏昭, 古屋 敦司, 奥山 克巳, 小口 健史, 熊澤 光生

    日本臨床麻酔学会誌  2000.9 

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    Language：Japanese  

  • 直線偏光近赤外線の星状神経節近傍照射が手掌発汗に与える影響 Major achievement

    野中　明彦,小口　健史,樫本　温,奥山　克巳,熊澤　光生

    日本ペインクリニック学会第34回大会  2000.7 

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    Event date： 2000.7

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京  

  • ラット摘出心臓におけるプロポフォールとチアミラールの虚血再灌流に及ぼす影響 Major achievement

    玉木　章雅,小口　健史,樫本　温,熊澤　光生

    第21回日本循環制御医学会総会  2000.5 

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    Event date： 2000.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京  

  • 硫酸マグネシウムを用いた褐色細胞腫の術中管理 Major achievement

    正宗　大士,石山　忠彦,川村　淳夫,鈴木　まほみ,小口　健史,熊澤　光生

    日本麻酔学会第47回大会  2000.4 

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    Event date： 2000.4

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京  

  • Effects of ATP-sensitive K channel on myocardial function and metabolism in the postischemic reperfused heart Major achievement

    Atsushi FURUYA,Satoshi KASHIMOTO,Atsuo KAWAMURA,Takeshi OGUCHI,Teruo KUMAZAWA

    International Anesthesia Research Society 74th Clinical and Scientific Congress  2000.3 

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    Event date： 2000.3

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Honolulu, Hawaii  

  • Effects of ATP-sensitive K channel on myocardial function and metabolism in the postischemic reperfused heart Major achievement

    Atsushi FURUYA,Satoshi KASHIMOTO,Atsuo KAWAMURA,Takeshi OGUCHI,Teruo KUMAZAWA

    6th America- Japan Anesthesia Congress  2000.3 

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    Event date： 2000.3

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Honolulu, Hawaii  

  • 高齢者と若年者における、プロポフォール麻酔時の、baroreflex sensitivityの違い Major achievement

    石山　忠彦,小口　健史,熊澤　光生

    第12回日本老年麻酔学会  2000.1 

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    Event date： 2000.1

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：和歌山  

  • 原発性アルドステロン症を合併した下顎骨骨折の麻酔経験

    菅原 健, 石山 忠彦, 小口 健史, 樫本 温, 熊澤 光生

    日本臨床麻酔学会誌  1998.9 

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    Language：Japanese  

  • プロテインC欠損症妊婦の帝王切開術の麻酔経験

    福岡 由起子, 石山 忠彦, 小口 健史, 樫本 温, 熊澤 光生

    日本臨床麻酔学会誌  1998.9 

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    Language：Japanese  

  • 18th Japan circulatory control medical society general meeting workshop. (3 ) . Good selected application of cardiotonics and hypertensive agents in intraoperative circulatory control. Usage of amrinone and milrinone in the intraoperative circulation

    小口健史

    循環制御  1998.6 

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  • 術中循環管理におけるアムリノンとミルリノンの使い方

    小口 健史

    循環制御  1997.5 

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  • Effects of prostacyclin analogue on function and metabolism in the ischemic working rat heart.

    小口健史, 樫本温, 中村敏弘, 熊沢光生

    麻酔  1991.9 

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  • Effect of mexiletine on cardiac function and metabolism.

    久米正記, 樫本温, 神田史大, 野中明彦, 小口健史, 熊沢光生

    麻酔  1990.9 

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    Language：Japanese  

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Teaching Experience (On-campus)

  • Biological management and ther apeuties advanced course

    2023Year

Professional Memberships

  • 日本臨床麻酔学会

    2018.9

  • American Society of Anesthesiologists

    1995.7

  • 日本麻酔科学会

    1987.5