酸化的蛋白修飾S-グルタチオン化は脂肪合成および肥満を促進する

2018年4月 - 2019年3月

山梨県  山梨県若手研究者奨励事業費補助金  基礎医学

肥満における酸化的蛋白修飾S-グルタチオン化の役割

2018年4月 - 2019年3月

上原生命科学財団  研究助成・特定研究助成  研究奨励金

循環器病における蛋白質S-グルタチオン化の動態及び役割の解明

2017年4月 - 2019年3月

日本学術振興会  科研費  若手研究(B)

循環器病における蛋白質S-グルタチオン化の動態及び役割の解明

研究課題/領域番号：17K15996  2017年4月 - 2019年3月

日本学術振興会  山梨大学  科学研究費助成事業 若手研究(B)  若手研究(B)

渡辺 陽介

Ｓ－グルタチオン化による心不全の治療法の開発

研究課題/領域番号：25860592  2013年4月 - 2014年3月

日本学術振興会  山梨大学  科学研究費助成事業 若手研究(B)  若手研究(B)

渡辺 陽介

ホスホリパーゼ A2 受容体の解析による心血管病の成因解明と新規治療薬の開発

研究課題/領域番号：22390158  2010年 - 2012年

日本学術振興会  山梨大学  科学研究費助成事業 基盤研究(B)  基盤研究(B)

久木山 清貴, 川端 健一, 尾畑 純栄, 齊藤 幸生, 渡辺 一広, 渡辺 陽介, 三品 秀人, 矢野 利明

The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation 査読

Journal of the American Heart Association   2021年6月( ISSN：2047-9980 )

Group V Secretory Phospholipase A 2 Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line

Journal of Atherosclerosis and Thrombosis   2021年5月( ISSN：1340-3478 )

Evaluation of renal tubulointerstitial damage as a residual renal risk factor for adverse cardiac events in patients with myocardial infarction

Journal of Cardiology   2021年4月( ISSN：0914-5087 )

Evaluation of renal tubulointerstitial damage as a residual renal risk factor for adverse cardiac events in patients with myocardial infarction 査読

Tsuyoshi Kobayashi , Takamitsu Nakamura , Manabu Uematsu , Takeo Horikoshi , Toru Yoshizaki , Yosuke Watanabe , Daisuke Fujioka , Yukio Saito , Kazuto Nakamura , Jyunei Obata , Kiyotaka Kugiyama

Journal of Cardiology   2021年4月( ISSN：0914-5087 )

Echolucency of carotid plaque is useful for selecting high-risk patients with chronic coronary artery disease who benefit from intensive lipid-lowering therapy

Journal of Cardiology   2021年1月( ISSN：0914-5087 )

Impact of persistent endothelial dysfunction in an infarct-related coronary artery on future major adverse cardiovascular event occurrence in STEMI survivors 査読

HEART AND VESSELS   2020年11月( ISSN：0910-8327 )

Improvement in Brachial Endothelial Vasomotor Function and Brachial-Ankle Pulse Wave Velocity Reduces the Residual Risk for Cardiovascular Events after Optimal Medical Treatment in Patients with Coronary Artery Disease 査読

Journal of Atherosclerosis and Thrombosis   2020年9月( ISSN：1340-3478 )

Protein S-glutathionylation stimulate adipogenesis by stabilizing C/EBPβ in 3T3L1 cells 査読 重要な業績

THE FASEB JOURNAL   2020年3月( ISSN：0892-6638 )

Improvement of endothelial dysfunction is mediated through reduction of remnant lipoprotein after statin therapy in patients with coronary artery disease 査読

Journal of Cardiology   2020年3月( ISSN：0914-5087 )

Persistent Dysfunction of Coronary Endothelial Vasomotor Responses is Related to Atheroma Plaque Progression in the Infarct-Related Coronary Artery of AMI Survivors 査読

Journal of Atherosclerosis and Thrombosis   2019年12月( ISSN：1340-3478 )

Pulmonary Vascular Resistance Is Associated With Brachial-Ankle Pulse-Wave Velocity and Adverse Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction 査読

JOURNAL OF CARDIAC FAILURE   2019年9月( ISSN：1071-9164 )

Wnt5a-Mediated Neutrophil Recruitment Has an Obligatory Role in Pressure Overload-Induced Cardiac Dysfunction 査読

CIRCULATION   2019年8月( ISSN：0009-7322 )

Redox regulation of ischemic limb neovascularization - What we have learned from animal studies 査読

Redox Biology   2017年5月( ISSN：2213-2317 )

Myocardial Production of Plasminogen Activator Inhibitor-1 is Associated with Coronary Endothelial and Ventricular Dysfunction after Acute Myocardial Infarction 査読

Journal of Atherosclerosis and Thrombosis   2016年10月( ISSN：1340-3478 )

The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells 査読

Redox Biology   2016年9月( ISSN：2213-2317 )

Remnant lipoproteinemia predicts cardiovascular events in patients with type 2 diabetes and chronic kidney disease 査読

AMERICAN JOURNAL OF CARDIOLOGY   2016年5月( ISSN：0002-9149 )

Redox Regulation of Ischemic Angiogenesis　- Another Aspect of Reactive Oxygen Species 査読

CIRCULATION JOURNAL   2016年5月( ISSN：1346-9843 )

Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1α and improve limb revascularization 査読

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   2016年( ISSN：0027-8424 )

Echolucency of carotid plaque is useful for assessment of residual cardiovascular risk in patients with chronic coronary artery disease who achieve LDL-C goals on statin therapy 査読

CIRCULATION JOURNAL   2014年11月( ISSN：1346-9843 )

Chronic depletion of glutathione exacerbates ventricular remodelling and dysfunction in the pressure-overloaded heart 査読

CARDIOVASCULAR RESEARCH   2012年11月( ISSN：0008-6363 )

Group X Secretory Phospholipase A2 in Neutrophils Plays a Pathogenic Role in Abdominal Aortic Aneurysms in Mice. 重要な業績

Kazuhiro WATANABE,Daisuke FUJIOKA,Yukio SAITO,Takamitsu NAKAMURA,Junei OBATA,Kenichi KAWABATA,Yosuke WATANABE,Hideto MISHINA,Syun TAMARU,Kiyotaka KUGIYAMA

American Heart Association Scientific Sessions 2011  2011年11月 

Association of Polymorphism in Glutamate-Cysteine Ligase Modifier Subunit Gene with Idiopathic Dilated Cardiomyopathy. 重要な業績

Kenichi KAWABATA,Tsuyoshi KOBAYASHI,Daisuke FUJIOKA,Syun TAMARU,Yosuke WATANABE,Kazuhiro WATANABE,Hideto MISHINA,Keita SANO,Takamitsu NAKAMURA,Yukio SAITO,Yoshinobu KITTA,Junei OBATA,Kiyotaka KUGIYAMA

American Heart Association Scientific Sessions 2011  2011年11月 

Group V Secretory Phospholipase A2 Plays an Important Role in the Pathogenesis of Myocardial Ischemia Reperfusion Injury 重要な業績

Toshiaki YANO,Daisuke FUJIOKA,Yukio SAITO,Takamitsu NAKAMURA,Junei OBATA,Kenichi KAWABATA,Kazuhiro WATANABE,Yosuke WATANABE,Hideto MISHINA,Syun TAMARU,Kiyotaka KUGIYAMA

The 75th Annual Scientific Meeting of the Japanese Circulation Society  2011年8月 

Group X Secretory Phospholipase A2 has a Critical Role in Neutrophils Activation and Myocardial Ischemia/reperfusion Injury in Mice 重要な業績

Daisuke FUJIOKA,Yukio SAITO,Tsuyoshi KOBAYASHI,Toshiaki YANO,Syun TAMARU,Yosuke WATANABE,Hideto MISHINA,Kazuhiro WATANABE,Takamitsu NAKAMURA,Junei OBATA,Kenichi KAWABATA,Kiyotaka KUGIYAMA

The 75th Annual Scientific Meeting of the Japanese Circulation Society  2011年8月 

Group V Secretory Phospholipase A2 Plays a Role in Myocardial Ischemia Reperfusion Injury Through Cytosolic Phospholipase A2. 重要な業績

Toshiaki YANO,Kenichi KAWABATA,Yukio SAITO,Kazuhiro WATANABE,Yosuke WATANABE,Hideto MISHINA,Syun TAMARU,Junei OBATA,Kiyotaka KUGIYAMA

American Heart Association Scientific Sessions 2010  2010年11月 

Mice Lacking the Glutamate-cysteine Ligase Modifier Subunit are Sensitive to Oxidative Stress Partly Through Reduction of Mitochondrial Glutathione. 重要な業績

Kenichi KAWABATA,Tsuyoshi KOBAYASHI,Yuri INO,Hideto MISHINA,Isao TAKISHIMA,Aritaka MAKINO,Kazuhiro WATANABE,Toshiaki YANO,Yosuke WATANABE,Mitsumasa HIRANO,Keita SANO,Yukio SAITO,Yasushi KODAMA,Yoshinobu KITTA,Junei OBATA,Kiyotaka KUGIYAMA

The 74th Annual Scientific Meeting of the Japanese Circulation Society  2010年3月 

Reduction in Myocardial Ischemia-reperfusion Injury in Group V Secretory Phospholipase A2-Deficient Mice. 重要な業績

Toshiaki YANO,Kenichi KAWABATA,Yukio SAITO,Tsuyoshi KOBAYASHI,Kazuhiro WATANABE,Yosuke WATANABE,Hideto MISHINA,Junei OBATA,Yoshinobu KITTA,Yasushi KODAMA,Keita SANO,Mitsumasa HIRANO,Aritaka MAKINO,Isao TAKISHIMA,Yuri INO,Kiyotaka KUGIYAMA

The 74th Annual Scientific Meeting of the Japanese Circulation Society  2010年3月 

Reduction in Myocardial Ischemia-reperfusion Injury in Group IV Cytosolic Phospholipase A2-deficient Mice Partly Due to Inhibition of TNF -mediated Pathway to Cell Injury. 重要な業績

Yukio SAITO,Yosuke WATANABE,Hideto MISHINA,Kazuhiro WATANABE,Toshiaki YANO,Tsuyoshi KOBAYASHI,Junei OBATA,Kenichi KAWABATA,Takao SHIMIZU,Kiyotaka KUGIYAMA

American Heart Association Scientific Sessions 2009  2009年11月 

Reduction in Myocardial Ischemia-reperfusion Injury in Group V Secretory Phospholipase A2-deficient Mice. 重要な業績

Toshiaki YANO,Kenichi KAWABATA,Yukio SAITO,Tsuyoshi KOBAYASHI,Ryota SATO,Kazuhiro WATANABE,Yosuke WATANABE,Hideto MISHINA,Junei OBATA,Kiyotaka KUGIYAMA

American Heart Association Scientific Sessions 2009  2009年11月 

Mice Lacking the Glutamate-Cysteine Ligase Modifier Subunit are Susceptible to Myocardial Ischemia-Reperfusion Injury Through Reduction of Mitochondrial Glutathione. 重要な業績

Tsuyoshi KOBAYASHI,Kenichi KAWABATA,Yukio SAITO,Daisuke FUJIOKA,Kazuto NAKAMURA,Toshiaki YANO,Ryota SATO,Kazuhiro WATANABE,Yosuke WATANABE,Junei OBATA,Takamitsu NAKAMURA,Sadahiro ITO,Timothy P DALTON,Kiyotaka KUGIYAMA

American Heart Association Scientific Sessions 2008  2008年11月 

Inhibition of Secretory Phospholipase A2 Activity Attenuates Acute Cardiogenic Pulmonary Congestion Induced by Isoproterenol Infusion in Mice with Post-Myocardial Infarction. 重要な業績

Kenichi KAWABATA,Tsuyoshi KOBAYASHI,Yosuke WATANABE,Kazuhiro WATANABE,Toshiaki YANO,Ryota SATO,Yukio SAITO,Kazuto NAKAMURA,Kiyotaka KUGIYAMA

American Heart Association Scientific Sessions 2008  2008年11月