Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Clinical Medicine (Cardiovascular medicine) Assistant Professor
Title
Assistant Professor
Watanabe Yosuke
Research History
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University of Yamanashi Department of Cardiovascular Medicine, University of Yamanashi Assistant Professor
2021.4
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University of Yamanashi Clinical Assistant Professor
2016.5 - 2021.3
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Boston University School of Medicine Vascular Biology section School of Medicine Vascular Biology section Post doctoral fellow
2013.5 - 2016.4
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University of Yamanashi (Internal Medicine Course Class 2 (Cardiovascular Medicine and Respiratory Medicine))
2008.4 - 2013.4
Education
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山梨大学大学院 医学工学総合教育部 先進医療科学
2008.4 - 2012.3
Country： Japan
Course： Doctor course
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山梨大学大学院医学工学総合教育学部博士課程
2008.4 - 2012.3
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University of Yamanashi
1999.4 - 2005.3
Degree
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学士(医学) ( 山梨大学 )
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博士(医学) ( 山梨大学 )
Research Areas
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Life Science / Cardiology
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Life Science / Cardiology
Research Interests
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Redox
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Cardiovascular disease
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S-glutathionylation
Subject of research
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心臓繊維芽細胞と心不全
Research Projects
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心臓線維芽細胞の老化と心不全：心臓線維芽細胞の再生と移植による新規心不全治療
2023.4 - 2025.3
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心臓線維芽細胞移植で老化した心臓を再生する
2023.1 - 2023.12
テルモ生命科学財団 研究助成
渡邉 陽介
Authorship：Principal investigator Type of fund：：Others
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心臓線維芽細胞の老化をターゲットとする新規心不全治療の開発
2022.4 - 2023.3
高橋産業経済研究財団 研究助成金
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S-glutathionylation on C/EBPb stimulates adipogenesis and obesity
Grant number：20K11528 2020.4 - 2023.3
Japan Society for the Promotion of Science University of Yamanashi Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
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新規S-グルタチオン化蛋白C/EBPbが活性酸素による肥満・脂肪合成を媒介する
2020.4 - 2022.3
日本学術振興会 科研費 基盤研究(C)
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酸化的蛋白修飾S-グルタチオン化は脂肪合成および肥満を促進する
2018.4 - 2019.3
山梨県 山梨県若手研究者奨励事業費補助金 基礎医学
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肥満における酸化的蛋白修飾S-グルタチオン化の役割
2018.4 - 2019.3
上原生命科学財団 研究助成・特定研究助成 研究奨励金
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循環器病における蛋白質S-グルタチオン化の動態及び役割の解明
2017.4 - 2019.3
日本学術振興会 科研費 若手研究(B)
Authorship：Principal investigator Type of fund：：Science research expense
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Roles of protein S-glutathionylation in cardiovascular disease
Grant number：17K15996 2017.4 - 2019.3
Japan Society for the Promotion of Science University of Yamanashi Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
WATANABE Yosuke
Extra cellar vesicles which like exosomes and microvesicles contain cytoplasm. Therefore there is a possibility that analysis of extra cellar vesicles can detect levels of S-glutathionylation high sensitivity compared with analysis of plasma. In this study, levels of S-glutathionylation in extra cellar vesicles in AMI and DCM patients are higher than control patients. This result indicate S-glutathionylation in extra cellar vesicles is a potential biomaker for cardio vascular diseases.
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Ｓ－グルタチオン化による心不全の治療法の開発
Grant number：25860592 2013.4 - 2014.3
日本学術振興会 科学研究費助成事業 若手研究(B) 若手研究(B)
渡辺 陽介
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Grant number：22390158 2010 - 2012
Japan Society for the Promotion of Science University of Yamanashi Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
KUGIYAMA Kiyotaka, KAWABATA Kenichi, OBATA Jun-ei, SAITO Yukio, WATANABE Kazuhiro, WATANABE Yohsuke, MISHINA Hideto, YANO Toshiaki
This study was aimed to examine a possible role of secretory PLA2receptor in the pathogenesis of cardiovascular diseases and to develop a new drug forprevention from cardiovascular diseases. As a result, (1) PLA2R－/－mice had a higherprevalence of cardiac rupture after MI compared with the PLA2R+/+mice. PLA2R－/－mice hada low content of collagen and a reduction in the number of myofibroblasts and theexpression of profibrogenic molecules in the infarct region. (2) The ovalbumin(OVA)-induced airway inflammation, characterized by an increased number of eosinophilsand neutrophils in BAL fluid and inflammatory histological changes in airway, was strongerin PLA2R－/－mice than in PLA2R+/+mice.
Papers
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Optimal medical therapy after percutaneous coronary intervention in very elderly patients with coronary artery disease Reviewed
2022.11( ISSN：2772-4875 )
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Prognostic Value of Novel Natriuretic Peptide Index After Percutaneous Coronary Intervention Reviewed
CIRCULATION JOURNAL 2022.10( ISSN：1346-9843 )
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A Propensity Score Matched Analysis of Statin Effects on Major Adverse Cardiac Events after Percutaneous Coronary Intervention in Patients Over 75 Years Old Reviewed
Takeo Horikoshi , Takamitsu Nakamura , Toru Yoshizaki , Jun Nakamura , Yosuke Watanabe 1, Manabu Uematsu , Aritaka Makino , Yukio Saito , Jun-Ei Obata , Takao Sawanobori , Hajime Takano , Ken Umetani , Akinori Watanabe , Tetsuya Asakawa , Akira Sato , Kiyotaka Kugiyama
INTERNAL MEDICINE 2022.2( ISSN：0918-2918 )
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Takotsubo Cardiomyopathy With Leaflet Valve Thrombosis 2 Years After Transcatheter Aortic Valve Replacement Reviewed
Toru Yoshizaki , Ryota Ando , Yosuke Watanabe , Tsuyoshi Kobayashi , Jun-Ei Obata
JACC-Cardiovascular Interventions 2021.12( ISSN：1936-8798 )
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Glutaredoxin-1 levels in plasma can predict future events in patients with cardiovascular diseases Reviewed
Yosuke Watanabe 1, Takamitsu Nakamura 2, Manabu Uematsu 2, Daisuke Fujioka 2, Daichi Inomata 2, Yukio Saito 2, Takeo Horikoshi 2, Toru Yoshizaki 2, Tsuyoshi Kobayashi 2, Kazuto Nakamura 2, Kiyotaka Kugiyama 2
FREE RADICAL BIOLOGY AND MEDICINE 2021.9( ISSN：0891-5849 )
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The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation Reviewed
Journal of the American Heart Association 2021.6( ISSN：2047-9980 )
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Group V Secretory Phospholipase A 2 Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line
Journal of Atherosclerosis and Thrombosis 2021.5( ISSN：1340-3478 )
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Evaluation of renal tubulointerstitial damage as a residual renal risk factor for adverse cardiac events in patients with myocardial infarction
Journal of Cardiology 2021.4( ISSN：0914-5087 )
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Evaluation of renal tubulointerstitial damage as a residual renal risk factor for adverse cardiac events in patients with myocardial infarction Reviewed
Tsuyoshi Kobayashi , Takamitsu Nakamura , Manabu Uematsu , Takeo Horikoshi , Toru Yoshizaki , Yosuke Watanabe , Daisuke Fujioka , Yukio Saito , Kazuto Nakamura , Jyunei Obata , Kiyotaka Kugiyama
Journal of Cardiology 2021.4( ISSN：0914-5087 )
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Echolucency of carotid plaque is useful for selecting high-risk patients with chronic coronary artery disease who benefit from intensive lipid-lowering therapy
Journal of Cardiology 2021.1( ISSN：0914-5087 )
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Impact of persistent endothelial dysfunction in an infarct-related coronary artery on future major adverse cardiovascular event occurrence in STEMI survivors Reviewed
HEART AND VESSELS 2020.11( ISSN：0910-8327 )
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Improvement in Brachial Endothelial Vasomotor Function and Brachial-Ankle Pulse Wave Velocity Reduces the Residual Risk for Cardiovascular Events after Optimal Medical Treatment in Patients with Coronary Artery Disease Reviewed
Journal of Atherosclerosis and Thrombosis 2020.9( ISSN：1340-3478 )
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Protein S-glutathionylation stimulate adipogenesis by stabilizing C/EBPβ in 3T3L1 cells Reviewed Major achievement
THE FASEB JOURNAL 2020.3( ISSN：0892-6638 )
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Improvement of endothelial dysfunction is mediated through reduction of remnant lipoprotein after statin therapy in patients with coronary artery disease Reviewed
Journal of Cardiology 2020.3( ISSN：0914-5087 )
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Persistent Dysfunction of Coronary Endothelial Vasomotor Responses is Related to Atheroma Plaque Progression in the Infarct-Related Coronary Artery of AMI Survivors Reviewed
Journal of Atherosclerosis and Thrombosis 2019.12( ISSN：1340-3478 )
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Pulmonary Vascular Resistance Is Associated With Brachial-Ankle Pulse-Wave Velocity and Adverse Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Reviewed
JOURNAL OF CARDIAC FAILURE 2019.9( ISSN：1071-9164 )
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Wnt5a-Mediated Neutrophil Recruitment Has an Obligatory Role in Pressure Overload-Induced Cardiac Dysfunction Reviewed
CIRCULATION 2019.8( ISSN：0009-7322 )
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Redox regulation of ischemic limb neovascularization - What we have learned from animal studies Reviewed
Redox Biology 2017.5( ISSN：2213-2317 )
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Myocardial Production of Plasminogen Activator Inhibitor-1 is Associated with Coronary Endothelial and Ventricular Dysfunction after Acute Myocardial Infarction Reviewed
Journal of Atherosclerosis and Thrombosis 2016.10( ISSN：1340-3478 )
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The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells Reviewed
Redox Biology 2016.9( ISSN：2213-2317 )
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Remnant lipoproteinemia predicts cardiovascular events in patients with type 2 diabetes and chronic kidney disease Reviewed
AMERICAN JOURNAL OF CARDIOLOGY 2016.5( ISSN：0002-9149 )
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Redox Regulation of Ischemic Angiogenesis - Another Aspect of Reactive Oxygen Species Reviewed
CIRCULATION JOURNAL 2016.5( ISSN：1346-9843 )
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Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1α and improve limb revascularization Reviewed
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2016( ISSN：0027-8424 )
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Echolucency of carotid plaque is useful for assessment of residual cardiovascular risk in patients with chronic coronary artery disease who achieve LDL-C goals on statin therapy Reviewed
CIRCULATION JOURNAL 2014.11( ISSN：1346-9843 )
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Chronic depletion of glutathione exacerbates ventricular remodelling and dysfunction in the pressure-overloaded heart Reviewed
CARDIOVASCULAR RESEARCH 2012.11( ISSN：0008-6363 )
Presentations
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Plasma levels of glutaredoxin-1 can predict future events in patients with cardiovascular diseases Major achievement
2023.3
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ペースメーカ植え込み後、左腕頭静脈閉塞と左鎖骨下動静脈シャントの合併により生じた左上肢浮腫に対してEVTを施行した一例 Major achievement
植松 学,二俣 美香,松岡 聡志,渡邉 陽介,出山 順太郎,小林 剛,藤岡 大佑,中村 貴光,齊藤 幸生,中村 和人,川端 健一,尾畑 純栄,久木山 清貴
第25回日本心血管インターベンション治療学会学術集会 2016.7
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Association of Polymorphism in Glutamate-cysteine Ligase Modifier Subunit Gene with Idiopathic Dilated Cardiomyopathy. Major achievement
Kenichi KAWABATA,Yosuke WATANABE,Hideto MISHINA,Kazuhiro WATANABE,Daisuke FUJIOKA,Yukio SAITO,Takamitsu NAKAMURA,Yoshinobu KITTA,Junei OBATA,Kiyotaka KUGIYAMA
The 77th Annual Scientific Meeting of the Japanase Circulation Society 2013.3
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Chronic Depletion of Glutathione Exacerbates Ventricular Remodeling and Dysfunction in Pressure Overloaded Heart in Mice Lacking the Glutamate-Cysteine Ligase Modifier Subunit. Major achievement
Yosuke WATANABE,Kazuhiro WATANABE,Tsuyoshi KOBAYASHI,Yukio SAITO,Daisuke FUJIOKA,Takamitsu NAKAMURA,Junei OBATA,Kenichi KAWABATA,Hideto MISHINA,Kiyotaka KUGIYAMA
American Heart Association Scientific Sessions 2012 2012.11
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Group X Secretory Phospholipase A2 in Neutrophils Plays a Pathogenic Role in Abdominal Aortic Aneurysms in Mice Major achievement
Kazuhiro WATANABE,Daisuke FUJIOKA,Yukio SAITO,Takamitsu NAKAMURA,Junei OBATA,Kenichi KAWABATA,Yosuke WATANABE,Hideto MISHINA,Syun TAMARU,Kiyotaka KUGIYAMA
The 76th Annual Scientific Meeting of the Japanese Circulation Society 2012.3
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Group X Secretory Phospholipase A2 in Neutrophils Plays a Pathogenic Role in Abdominal Aortic Aneurysms in Mice. Major achievement
Kazuhiro WATANABE,Daisuke FUJIOKA,Yukio SAITO,Takamitsu NAKAMURA,Junei OBATA,Kenichi KAWABATA,Yosuke WATANABE,Hideto MISHINA,Syun TAMARU,Kiyotaka KUGIYAMA
American Heart Association Scientific Sessions 2011 2011.11
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Association of Polymorphism in Glutamate-Cysteine Ligase Modifier Subunit Gene with Idiopathic Dilated Cardiomyopathy. Major achievement
Kenichi KAWABATA,Tsuyoshi KOBAYASHI,Daisuke FUJIOKA,Syun TAMARU,Yosuke WATANABE,Kazuhiro WATANABE,Hideto MISHINA,Keita SANO,Takamitsu NAKAMURA,Yukio SAITO,Yoshinobu KITTA,Junei OBATA,Kiyotaka KUGIYAMA
American Heart Association Scientific Sessions 2011 2011.11
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Group V Secretory Phospholipase A2 Plays an Important Role in the Pathogenesis of Myocardial Ischemia Reperfusion Injury Major achievement
Toshiaki YANO,Daisuke FUJIOKA,Yukio SAITO,Takamitsu NAKAMURA,Junei OBATA,Kenichi KAWABATA,Kazuhiro WATANABE,Yosuke WATANABE,Hideto MISHINA,Syun TAMARU,Kiyotaka KUGIYAMA
The 75th Annual Scientific Meeting of the Japanese Circulation Society 2011.8
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Group X Secretory Phospholipase A2 has a Critical Role in Neutrophils Activation and Myocardial Ischemia/reperfusion Injury in Mice Major achievement
Daisuke FUJIOKA,Yukio SAITO,Tsuyoshi KOBAYASHI,Toshiaki YANO,Syun TAMARU,Yosuke WATANABE,Hideto MISHINA,Kazuhiro WATANABE,Takamitsu NAKAMURA,Junei OBATA,Kenichi KAWABATA,Kiyotaka KUGIYAMA
The 75th Annual Scientific Meeting of the Japanese Circulation Society 2011.8
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Group V Secretory Phospholipase A2 Plays a Role in Myocardial Ischemia Reperfusion Injury Through Cytosolic Phospholipase A2. Major achievement
Toshiaki YANO,Kenichi KAWABATA,Yukio SAITO,Kazuhiro WATANABE,Yosuke WATANABE,Hideto MISHINA,Syun TAMARU,Junei OBATA,Kiyotaka KUGIYAMA
American Heart Association Scientific Sessions 2010 2010.11
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Mice Lacking the Glutamate-cysteine Ligase Modifier Subunit are Sensitive to Oxidative Stress Partly Through Reduction of Mitochondrial Glutathione. Major achievement
Kenichi KAWABATA,Tsuyoshi KOBAYASHI,Yuri INO,Hideto MISHINA,Isao TAKISHIMA,Aritaka MAKINO,Kazuhiro WATANABE,Toshiaki YANO,Yosuke WATANABE,Mitsumasa HIRANO,Keita SANO,Yukio SAITO,Yasushi KODAMA,Yoshinobu KITTA,Junei OBATA,Kiyotaka KUGIYAMA
The 74th Annual Scientific Meeting of the Japanese Circulation Society 2010.3
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Reduction in Myocardial Ischemia-reperfusion Injury in Group V Secretory Phospholipase A2-Deficient Mice. Major achievement
Toshiaki YANO,Kenichi KAWABATA,Yukio SAITO,Tsuyoshi KOBAYASHI,Kazuhiro WATANABE,Yosuke WATANABE,Hideto MISHINA,Junei OBATA,Yoshinobu KITTA,Yasushi KODAMA,Keita SANO,Mitsumasa HIRANO,Aritaka MAKINO,Isao TAKISHIMA,Yuri INO,Kiyotaka KUGIYAMA
The 74th Annual Scientific Meeting of the Japanese Circulation Society 2010.3
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Reduction in Myocardial Ischemia-reperfusion Injury in Group IV Cytosolic Phospholipase A2-deficient Mice Partly Due to Inhibition of TNF -mediated Pathway to Cell Injury. Major achievement
Yukio SAITO,Yosuke WATANABE,Hideto MISHINA,Kazuhiro WATANABE,Toshiaki YANO,Tsuyoshi KOBAYASHI,Junei OBATA,Kenichi KAWABATA,Takao SHIMIZU,Kiyotaka KUGIYAMA
American Heart Association Scientific Sessions 2009 2009.11
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Reduction in Myocardial Ischemia-reperfusion Injury in Group V Secretory Phospholipase A2-deficient Mice. Major achievement
Toshiaki YANO,Kenichi KAWABATA,Yukio SAITO,Tsuyoshi KOBAYASHI,Ryota SATO,Kazuhiro WATANABE,Yosuke WATANABE,Hideto MISHINA,Junei OBATA,Kiyotaka KUGIYAMA
American Heart Association Scientific Sessions 2009 2009.11
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Mice Lacking the Glutamate-Cysteine Ligase Modifier Subunit are Susceptible to Myocardial Ischemia-Reperfusion Injury Through Reduction of Mitochondrial Glutathione. Major achievement
Tsuyoshi KOBAYASHI,Kenichi KAWABATA,Yukio SAITO,Daisuke FUJIOKA,Kazuto NAKAMURA,Toshiaki YANO,Ryota SATO,Kazuhiro WATANABE,Yosuke WATANABE,Junei OBATA,Takamitsu NAKAMURA,Sadahiro ITO,Timothy P DALTON,Kiyotaka KUGIYAMA
American Heart Association Scientific Sessions 2008 2008.11
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Inhibition of Secretory Phospholipase A2 Activity Attenuates Acute Cardiogenic Pulmonary Congestion Induced by Isoproterenol Infusion in Mice with Post-Myocardial Infarction. Major achievement
Kenichi KAWABATA,Tsuyoshi KOBAYASHI,Yosuke WATANABE,Kazuhiro WATANABE,Toshiaki YANO,Ryota SATO,Yukio SAITO,Kazuto NAKAMURA,Kiyotaka KUGIYAMA
American Heart Association Scientific Sessions 2008 2008.11
Teaching Experience (On-campus)
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臨床医学概論講義
2023Year
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修士課程臨床医学概論
2023Year Type of subject：Dr. (Graduate School)
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臨床医学概論講義
2022Year
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修士課程臨床医学概論
2022Year Type of subject：Dr. (Graduate School)
Guidance results
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2022
Type：Achievement of hospital training physicians guidance
Number of people receiving guidance ：10people
Professional Memberships
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日本循環器学会
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日本内科学会