中国南京大学医学部附属金陵病院   腎臓病研究所　   主治医生

1992.10 - 1995.2

新潟大学医学部   附属腎研究施設免疫病態学部門   笹川財団研究生

1991.10 - 1992.9

中国南京大学医学部附属金陵病院   腎臓病研究所   医師

1987.10 - 1991.9

中国南京大学医学部附属金陵病院   腎臓病研究所   医師

1987.10 - 1991.9

アレルギー性気道炎症反応におけるギャップ結合を介した細胞間コミュニケーションの役割と治療への応用

2015.4 - 2016.3

抗酸化作用を持つ免疫グロブリンの製作と感染症治療における応用  Major achievement

2023.4 - 2024.3

山梨大学  山梨大学戦略プロジェクト  萌芽研究トライアル

抗酸化作用を持つ免疫グロブリンの製作と感染症治療における応用  Major achievement

2023.3 - 2025.3

小林財団  小林財団12回研究助成 

Role of gap junction protein connexin43 in B cell activation and lupus nephritis

2020.4 - 2022.3

基盤研究(C)

姚 建

Role of gap junction protein connexin43 in B cell activation and lupus nephritis

2020.4 - 2022.3

基盤研究(C)

姚 建

TRPV4とコネクシン・パネキシン相互作用に着目した間質性膀胱炎の病態解明

2017.4 - 2020.3

基盤研究(C)

TRPV4とコネクシン・パネキシン相互作用に着目した間質性膀胱炎の病態解明

2017.4 - 2020.3

基盤研究(C)

アレルギー性気道炎症反応におけるギャップ結合を介した細胞間コミュニケーションの役割と治療への応用

2015.4 - 2016.3

アレルギー性気道炎症反応におけるギャップ結合を介した細胞間コミュニケーションの役割と治療への応用

2015.4 - 2016.3

閉塞膀胱の病態におけるコネキシンヘミチャネルの役割

2014.4 - 2017.3

糸球体足細胞傷害におけるギャップ結合タンパクconnexin43の役割

2014.4 - 2017.3

新規低侵襲パーソナル3次元表皮の応用―アトピー性皮膚炎新規遺伝子異常の探索―

2014.4 - 2017.3

閉塞膀胱の病態におけるコネキシンヘミチャネルの役割

2014.4 - 2017.3

糸球体足細胞傷害におけるギャップ結合タンパクconnexin43の役割

2014.4 - 2017.3

新規低侵襲パーソナル3次元表皮の応用―アトピー性皮膚炎新規遺伝子異常の探索―

2014.4 - 2017.3

腎虚血再灌流障害におけるギャップ結合を介した細胞間コミュニケーションの役割

2011.4 - 2014.3

腎虚血再灌流障害におけるギャップ結合を介した細胞間コミュニケーションの役割

2011.4 - 2014.3

腎虚血再灌流障害におけるギャップ結合を介した細胞間コミュニケーションの役割

2011.4 - 2014.3

ギャップ結合をターゲットとしたアレルギー性気道炎症の新規治療法の開発

2011.4 - 2012.3

ギャップ結合をターゲットとしたアレルギー性気道炎症の新規治療法の開発

2011.4 - 2012.3

ギャップ結合をターゲットとしたアレルギー性気道炎症の新規治療法の開発

2011.4 - 2012.3

インスリン抵抗性に伴うレニン産生・分泌異常の分子機構の解明

2010.4 - 2011.3

インスリン抵抗性に伴うレニン産生・分泌異常の分子機構の解明

2010.4 - 2011.3

インスリン抵抗性に伴うレニン産生・分泌異常の分子機構の解明

2010.4 - 2011.3

研究特別奨励賞・山梨大学医学部

2009.6 - 2010.3

ギャップ結合ヘミチャネルを介した新たなレニン分泌調節機構の解明

2009.6 - 2010.3

ギャップ結合ヘミチャネルを介した新たなレニン分泌調節機構の解明

2009.6 - 2010.3

研究特別奨励賞・山梨大学医学部

2009.6 - 2010.3

ギャップ結合ヘミチャネルを介した新たなレニン分泌調節機構の解明

2009.6 - 2010.3

研究特別奨励賞・山梨大学医学部

2009.6 - 2010.3

腎疾患における小胞体ストレス応答の意義の解明と新規治療戦略の開発

2008.4 - 2013.3

腎疾患における小胞体ストレス応答の意義の解明と新規治療戦略の開発

2008.4 - 2013.3

腎疾患における小胞体ストレス応答の意義の解明と新規治療戦略の開発

2008.4 - 2013.3

コネクシン、パネキシンによる皮膚炎症制御の解析

2008.4 - 2012.3

コネクシン、パネキシンによる皮膚炎症制御の解析

2008.4 - 2012.3

コネクシン、パネキシンによる皮膚炎症制御の解析

2008.4 - 2012.3

腎傍糸球体におけるレニン分泌制御機構：細胞間コミュニケーションの役割

2008.4 - 2011.3

腎傍糸球体におけるレニン分泌制御機構：細胞間コミュニケーションの役割

2008.4 - 2011.3

腎傍糸球体におけるレニン分泌制御機構：細胞間コミュニケーションの役割

2008.4 - 2011.3

遺伝子工学技術を用いた生体内および生体外環境監視のためのバイオセンサーシステム群の開発

2007.9 - 2008.3

腎傍糸球体装置におけるレニン分泌制御機構： 細胞間カルシウムウェーブ(intercellular calcium wave)の関与

2007.9 - 2008.3

遺伝子工学技術を用いた生体内および生体外環境監視のためのバイオセンサーシステム群の開発

2007.9 - 2008.3

腎傍糸球体装置におけるレニン分泌制御機構： 細胞間カルシウムウェーブ(intercellular calcium wave)の関与

2007.9 - 2008.3

遺伝子工学技術を用いた生体内および生体外環境監視のためのバイオセンサーシステム群の開発

2007.9 - 2008.3

腎傍糸球体装置におけるレニン分泌制御機構： 細胞間カルシウムウェーブ(intercellular calcium wave)の関与

2007.9 - 2008.3

腎傍糸球体装置におけるレニン分泌制御機構

2007.5 - 2008.5

腎傍糸球体装置におけるレニン分泌制御機構

2007.5 - 2008.5

腎傍糸球体装置におけるレニン分泌制御機構

2007.5 - 2008.5

腎傍糸球体装置におけるレニン分泌制御機構：　ギャップ結合と血管内皮由来弛緩因子の役割

2006.9 - 2008.3

腎傍糸球体装置におけるレニン分泌制御機構： ギャップ結合と血管内皮由来弛緩因子の役割

2006.9 - 2008.3

腎傍糸球体装置におけるレニン分泌制御機構： ギャップ結合と血管内皮由来弛緩因子の役割

2006.9 - 2008.3

血管再生における細胞間情報伝達の解析

2006.9 - 2007.3

血管再生における細胞間情報伝達の解析

2006.9 - 2007.3

血管再生における細胞間情報伝達の解析

2006.9 - 2007.3

免疫・炎症反応におけるギャップ結合の機能の解析及びギャップ結合阻害外用剤の開発

2006.4 - 2008.3

免疫・炎症反応におけるギャップ結合の機能の解析及びギャップ結合阻害外用剤の開発

2006.4 - 2008.3

免疫・炎症反応におけるギャップ結合の機能の解析及びギャップ結合阻害外用剤の開発

2006.4 - 2008.3

炎症性腎障害と腎総組織修復におけるギャップ結合を介した細胞間コミュニケーションの役割

2005.10 - 2006.3

炎症性腎障害と腎総組織修復におけるギャップ結合を介した細胞間コミュニケーションの役割

2005.10 - 2006.3

炎症性腎障害と腎総組織修復におけるギャップ結合を介した細胞間コミュニケーションの役割

2005.10 - 2006.3

腎傍糸球体装置におけるレニン分泌制御機構

2004.9 - 2005.3

免疫担当細胞におけるギャップ結合の役割の解明：ギャップ結合阻害による抗炎症剤/免疫抑制剤の開発を目指して

2004.9 - 2005.3

遺伝子工学技術を用いた生体内および生体外環境のIn Vivoセンサーシステム群の開発

2004.9 - 2005.3

遺伝子工学技術を用いた生体内および生体外環境のIn Vivoセンサーシステム群の開発

2004.9 - 2005.3

腎傍糸球体装置におけるレニン分泌制御機構

2004.9 - 2005.3

免疫担当細胞におけるギャップ結合の役割の解明：ギャップ結合阻害による抗炎症剤/免疫抑制剤の開発を目指して

2004.9 - 2005.3

遺伝子工学技術を用いた生体内および生体外環境のIn Vivoセンサーシステム群の開発

2004.9 - 2005.3

腎傍糸球体装置におけるレニン分泌制御機構

2004.9 - 2005.3

免疫担当細胞におけるギャップ結合の役割の解明：ギャップ結合阻害による抗炎症剤/免疫抑制剤の開発を目指して

2004.9 - 2005.3

糸球体内皮細胞によるメサンギウム細胞機能制御の分子機構・ギャップ結合の役割

2004.5 - 2005.3

糸球体内皮細胞によるメサンギウム細胞機能制御の分子機構・ギャップ結合の役割

2004.5 - 2005.3

糸球体内皮細胞によるメサンギウム細胞機能制御の分子機構・ギャップ結合の役割

2004.5 - 2005.3

遺伝子工学技術を用いた生体内バイオセンサー ＿＿腎疾患の診断・治療を目的とした21世紀型先進医療システムの構築

2004.4 - 2008.3

遺伝子工学技術を用いた生体内バイオセンサー ＿＿腎疾患の診断・治療を目的とした21世紀型先進医療システムの構築

2004.4 - 2008.3

遺伝子工学技術を用いた生体内バイオセンサー ＿＿腎疾患の診断・治療を目的とした21世紀型先進医療システムの構築

2004.4 - 2008.3

ギャップ結合を介した血管内皮細胞由来弛緩因子による傍糸球体細胞レニン分泌制御機構

2004.4 - 2006.3

ギャップ結合を介した血管内皮細胞由来弛緩因子による傍糸球体細胞レニン分泌制御機構

2004.4 - 2006.3

ギャップ結合を介した血管内皮細胞由来弛緩因子による傍糸球体細胞レニン分泌制御機構

2004.4 - 2006.3

小児の内分泌撹乱物質暴露のリスク軽減を向けて：トランスジェニック・センサーマウスを用いた環境中ダイオキシン類のバイオモニタリングシステムの構築

2004.4 - 2005.3

小児の内分泌撹乱物質暴露のリスク軽減を向けて：トランスジェニック・センサーマウスを用いた環境中ダイオキシン類のバイオモニタリングシステムの構築

2004.4 - 2005.3

小児の内分泌撹乱物質暴露のリスク軽減を向けて：トランスジェニック・センサーマウスを用いた環境中ダイオキシン類のバイオモニタリングシステムの構築

2004.4 - 2005.3

糸球体内皮細胞によるメサンギウム細胞機能制御の分子機構・ギャップ結合の役割

2003.5 - 2004.3

ﾒｻﾝｷﾞｳﾑ細胞合胞体の機能解析から糸球体硬化進展機構解明への展開

2003.5 - 2004.3

ﾒｻﾝｷﾞｳﾑ細胞合胞体の機能解析から糸球体硬化進展機構解明への展開

2003.5 - 2004.3

糸球体内皮細胞によるメサンギウム細胞機能制御の分子機構・ギャップ結合の役割

2003.5 - 2004.3

ﾒｻﾝｷﾞｳﾑ細胞合胞体の機能解析から糸球体硬化進展機構解明への展開

2003.5 - 2004.3

糸球体内皮細胞によるメサンギウム細胞機能制御の分子機構・ギャップ結合の役割

2003.5 - 2004.3

傍糸球体細胞のレニン分泌制御機構:細胞間カルシウムウェーブ(intercellular calcium wave) の関与

2003.4 - 2004.3

傍糸球体細胞のレニン分泌制御機構:細胞間カルシウムウェーブ(intercellular calcium wave) の関与

2003.4 - 2004.3

傍糸球体細胞のレニン分泌制御機構:細胞間カルシウムウェーブ(intercellular calcium wave) の関与

2003.4 - 2004.3

腎糸球体及び間質における血行力学の因子の解析

2003.1

腎糸球体及び間質における血行力学の因子の解析

2003.1

腎糸球体及び間質における血行力学の因子の解析

2003.1

ATPによる傍糸球体細胞のレニン分泌制御機構

2002.5 - 2003.5

ATPによる傍糸球体細胞のレニン分泌制御機構

2002.5 - 2003.5

ATPによる傍糸球体細胞のレニン分泌制御機構

2002.5 - 2003.5

傍糸球体装置のシグナル伝達：ギャップ結合・カルシウムウェーブの役割

2001.5 - 2003.3

傍糸球体装置のシグナル伝達：ギャップ結合・カルシウムウェーブの役割

2001.5 - 2003.3

傍糸球体装置のシグナル伝達：ギャップ結合・カルシウムウェーブの役割

2001.5 - 2003.3

IgA沈着とメサンギウム細胞合胞体機能：ギャップ結合から見た解析

2001.5 - 2002.5

IgA沈着とメサンギウム細胞合胞体機能：ギャップ結合から見た解析

2001.5 - 2002.5

IgA沈着とメサンギウム細胞合胞体機能：ギャップ結合から見た解析

2001.5 - 2002.5

糸球体メサンギウム細胞のギャップ結合蛋白とシグナル伝達

2001.4 - 2002.3

レニン分泌制御とギャップ結合

2001.4 - 2002.3

レニン分泌制御とギャップ結合

2001.4 - 2002.3

糸球体メサンギウム細胞のギャップ結合蛋白とシグナル伝達

2001.4 - 2002.3

レニン分泌制御とギャップ結合

2001.4 - 2002.3

糸球体メサンギウム細胞のギャップ結合蛋白とシグナル伝達

2001.4 - 2002.3

Hydrogen sulfide as a potent scavenger of toxicant acrolein. Reviewed Major achievement

Mao Z, Huang Y, Li B, Tomoya K, Shinmori H, Zeng X, Gu Z, Yao J.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY   229 ( 113111. )   2022.1( ISSN：0147-6513 )

Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury Reviewed Major achievement

Yan Q, Mao Z, Hong J, Gao K, Niimi M, Mitsui T, Yao J.

Antioxidants   10 ( 7 )   1007   2021.6

Reductively modified albumin attenuates DSS-Induced mouse colitis through rebalancing systemic redox state Reviewed Major achievement

Xiawen Yang, Zhimin Mao, Yanru Huang, Haizhao Yan, Qiaojing Yan, Jingru Hong, Jianglin Fan, Jian Yao

Redox Biology   May ( 41 )   101881   2021.2( ISSN：2213-2317 )

Gap junctions amplify TRPV4 activation-initiated cell injury via modification of intracellular Ca2+ and Ca2+-dependent regulation of TXNIP Reviewed Major achievement

Xiling Zhang, Zhimin Mao, Yanru Huang, Zhen Zhang, Jian Yao

Channels   14 ( 1 )   246 - 256   2020.8( ISSN：1933-6950 )

Connexin Hemichannels Contribute to the Activation of cAMP Signaling Pathway and Renin Production Reviewed

Jingru Hong, Jian Yao

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   21 ( 12 )   4462   2020.6

Hydrogen Sulfide Mediates Tumor Cell Resistance to Thioredoxin Inhibitor Reviewed

Zhimin Mao, Xiawen Yang, Sayumi Mizutani, Yanru Huang, Zhen Zhang, Hideyuki Shinmori, Kun Gao and Jian Yao

Frontiers in Oncology   10 ( artical 252 )   2020.3( ISSN：2234-943X )

Connexin43 Contributes to Inflammasome Activation and Lipopolysaccharide-Initiated Acute Renal Injury via Modulation of Intracellular Oxidative Status Reviewed Major achievement

X, Zhang X, Huang Y, Mitsui T, Fan J, Takeda M, Yao J

ANTIOXIDANTS & REDOX SIGNALING   31 ( 16 )   1194 - 1212   2019.12( ISSN：1523-0864 )

Connexin43 Is Required for the Effective Activation of Spleen Cells and Immunoglobulin Production Reviewed Major achievement

Yanru Huang, Zhimin Mao, Xiling Zhang, Xiawen Yang, Norifumi Sawada, Masayuki Takeda and Jian Yao

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   20 ( 22 )   pii: E5789   2019.11( ISSN：1422-0067 )

Hydrogen sulfide donor NaHS alters antibody structure and function via sulfhydration Reviewed Major achievement

Zhang Z, Fang X, Yang X, Mitsui T, Huang Y, Mao Z, Huang Y, Takeda M, Yao J.

INTERNATIONAL IMMUNOPHARMACOLOGY   73   491 - 501   2019.8( ISSN：1567-5769 )

Pharmacological levels of hydrogen sulfide inhibit oxidative cell injury through regulating the redox state of thioredoxin Reviewed Major achievement

Mao Z, Huang Y, Zhang Z, Yang X, Zhang X, Huang Y, Sawada N, Mitsui T, Takeda M, Yao J

FREE RADICAL BIOLOGY AND MEDICINE   11   190 - 199   2019.1( ISSN：0891-5849 )

Pathomechanisms of pericyte-myofibroblast transition in kidney and interventional effects of Chinese herbal medicine] Reviewed

　   43 ( 21 )   4192 - 4197   2018.11

Induction of inactive TGF-β1 monomer formation by hydrogen sulfide contributes to its suppressive effects on Ang II- and TGF-β1-induced EMT in renal tubular epithelial cells Reviewed

Huang Y, Zhang Z, Huang Y, Mao Z, Yang X, Nakamura Y, Sawada N, Mitsui T, Takeda M, Yao J

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   501 ( 2 )   534 - 540   2018.5( ISSN：0006-291X )

The pivotal role of extracellular signal-regulated kinase in gap junction-mediated regulation of TXNIP. Reviewed Major achievement

Gao S, Zhang X, Gao K, Zhang Z, Huang Y, Yoda R, Yao J.

CELLULAR SIGNALLING   8 ( 38 )   116 - 126   2017.10( ISSN：0898-6568 )

Carbenoxolone inhibits TRPV4 channel-initiated oxidative urothelial injury and ameliorates cyclophosphamide-induced bladder dysfunction Reviewed Major achievement

Zhang X, Gao S, Tanaka M, Zhang Z, Huang Y, Mitsui T, Kamiyama M, Koizumi S, Fan J, Takeda M, Yao J.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE   21 ( 9 )   1791 - 1802   2017.9( ISSN：1582-4934 )

Glutathione inhibits antibody and complement-mediated immunologic cell injury via multiple mechanisms. Reviewed Major achievement

Zhang Z, Zhang X, Fang X, Niimi M, Huang Y, Piao H, Gao S, Fan J, Yao J.

Redox Biology   12   571 - 581   2017.8( ISSN：2213-2317 )

Pathogenesis and treatment of insulin resistance in chronic kidney disease and interventional effects of Chinese herbal medicine Reviewed

WU Wei, YANG Jing-jing, Wan Yi-gang, TU Yue, SHI Ge, HAN Wen-bei, LIU Bu-hui, YAO Jian

China journal of Chinese materia medica   42 ( 1 )   49 - 55   2017.1( ISSN：1001-5302 )

Suramin inhibits antibody binding to cell surface antigens and disrupts complement-mediated mesangial cell lysis Reviewed Major achievement

JOURNAL OF PHARMACOLOGICAL SCIENCES   132 ( 4 )   224 - 234   2016.12( ISSN：1347-8613 )

Effects and mechanisms of Shenkang injection promoting extracellular matrix degradation via regulating ERK1/2/MMPs signaling pathway in renal failure rats Reviewed

YANG Jing-jing, MAO Zhi-min, WAN Yi-gang, Wu Wei, HUANG Yan-ru, SHI Ge, HAN Wen-bei, YAO Jian

China Journal of Chinese Materia Medica   41 ( 20 )   3805 - 3813   2016.10( ISSN：1001-5302 )

Pathomechanisms of podocyte injury in diabetic nephropathy and interventional effects of Chinese herbal medicine Reviewed

SHI Ge, MAO Zhi-min, WAN Yi-gang, SHEN Shan-mei, WU Wei, YANG Jing-jing, YAO Jian

China Journal of Chinese Materia Medica   41 ( 13 )   2416 - 2421   2016.9( ISSN：1001-5302 )

Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status Reviewed Major achievement

Chi Y, Zhang X, Zhang Z, Mitsui T, Kamiyama M, Takeda M, Yao J.

Redox Biology   9   198 - 209   2016.9( ISSN：2213-2317 )

Upregulation of connexin43 contributes to PX-12-induced oxidative cell death. Reviewed Major achievement

TUMOR BIOLOGY   37 ( 6 )   7535 - 7546   2016.6( ISSN：1010-4283 )

AMPK Suppresses Connexin43 Expression in the Bladder and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis. Reviewed Major achievement

Sci Rep   6   19708   2016.1

Regulative mechanisms of mammalian target of rapamycin signaling pathway in glomerular hypertrophy in diabetic nephropathy and interventional effects of Chinese herbal medicine Reviewed

China Journal of Chinese Materia Medica   40 ( 16 )   3125   2015.4

eIF2-independent suppression of TNF--triggered NF-B activation by salubrinal Reviewed Major achievement

Biol Pharm Bull   38 ( 9 )   1368 - 1374   2015.3

A novel TXNIP-based mechanism for Cx43-mediated regulation of oxidative drug injury Reviewed Major achievement

J Cell Mol Med   2015.3

p53 protein-mediated up-regulation of MAP kinase phosphatase 3 (MKP-3) contributes to the establishment of the cellular senescent phenotype through dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) Reviewed Major achievement

J Biol Chem   290 ( 2 )   1129 - 40   2015.1

Suppression of cell membrane permeability by suramin: involvement of its inhibitory actions on connexin 43 hemichannels Reviewed Major achievement

British Journal of Pharmacology   ( 171 )   3448 - 3462   2014.7

Purinergic control of AMPK activation by ATP released through connexin 43 hemichannels - pivotal roles in hemichannel-mediated cell injury Reviewed Major achievement

J Cell Sci   127 ( 7 )   1487 - 1499   2014.3

5'-AMP-activated protein kinase attenuates adriamycin-induced oxidative podocyte injury through thioredoxin-mediated suppression of the apoptosis signal-regulating kinase 1-P38 signaling pathway Reviewed Major achievement

Mol Pharmacol   85 ( 3 )   460 - 471   2013.12

Eviprostat Activates cAMP Signaling Pathway and Suppresses Bladder Smooth Muscle Cell Proliferation Reviewed Major achievement

International Journal of Molecular Science   14   12107 - 12122   2013.6

Connexin43 Hemichannel-Mediated Regulation of Connexin43 Reviewed Major achievement

PLOS ONE   8 ( 2 )   e58057   2013.2

NADPH oxidase-mediated upregulation of connexin43 contributes to podocyte injury Reviewed Major achievement

Free Radic Biol Med   53 ( 6 )   1286 - 1297   2012.9

Unfolded protein response causes a phenotypic shift of inflamed glomerular cells towards redifferentiation through dual blockade of Akt and Smad signaling pathways Reviewed

Johno H, ,Nakajima S, ,Kato H, ,Yao J, ,Paton AW, ,Paton JC, ,Katoh R, ,Shimizu F, ,Kitamura M

Am J Pathol   181 ( 6 )   1977 - 1990   2012.8

β-Catenin Signaling Contributes to Platelet Derived Growth Factor Elicited Bladder Smooth Muscle Cell Contraction Through Up-Regulation of Cx43 Expression Reviewed Major achievement

LI Kai,Jian YAO,Norifumi SAWADA,Masanori KITAMURA,Karl-Erik Andersson,Masayuki Takeda

THE JOURNAL OF UROLOGY   188 ( 1 )   307 - 315   2012.7

Cordycepin as a sensitizer to TNF-α-induced apoptosis through eIF2α- and mTORC1- mediated inhibition of NF-κB Reviewed Major achievement

Kadomatsu M,Nakajima S,Kato H,Gu L,Chi Y,Yao J,Kitamura M

Clin Exp Immunol   168   325 - 332   2012.6

Reciprocal regulation between proinflammatory cytokine-induced inducible NO synthase (iNOS) and connexin 43 in bladder smooth muscle cells Reviewed Major achievement

LI Kai,Jian YAO,Liye Shi,Norifumi SAWADA,Yuan Chi,Qiaojing Yan,Hiroyuki Matsue,Masanori KITAMURA,Masayuki Takeda

JOURNAL OF BIOLOGICAL CHEMISTRY   286 ( 48 )   41552 - 41562   2011.12

Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase Reviewed Major achievement

Chi Y,Li K,Yan Q,Koizumi S,Shi L,Takahashi S,Zhu Y,Matsue H,Takeda M,Kitamura M,Yao J

J Pharmacol Exp Ther   339   257 - 266   2011.10

Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin Reviewed Major achievement

Tian T,Zhao Y,Nakajima S,Huang T,Yao J,Paton AW,Paton JC,Kitamura M

Biochem Biophys Res Commun   410   852 - 858   2011.7

Connexin43 hemichannels contribute to cadmium-induced oxidative stress and cell injury Reviewed Major achievement

Fang X,Huang T,Zhu Y,Jiang JX,Wang P,Kitamura M,Yao J

Antioxid Redox Signal   14 ( 2 )   2427 - 2439   2011.6

Selective abrogation of BiP/GRP78 blunts activation of NF-kB through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt Reviewed Major achievement

Nakajima S,Hiramatsu N,Hayakawa K,Saito Y,Kato H,Huang T,Yao J,Paton AW,Paton JC,Kitamura M

Mol Cell Biol   131   1710 - 1718   2011.2

Impairment of MCP-1 expression in mesothelial cells exposed to PDF by osmotic stress and acidic stress Reviewed Major achievement

Ogata R,Hiramatsu N,Hayakawa K,Nakajima S,Yao J,Kobayashi T,Kitamura M

Perit Dial Int   31   80 - 89   2011.1

Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response Reviewed Major achievement

Zhao Y,Tian T,Huang T,Nakajima S,Saito Y,Takahashi S,Yao J,Paton AW,Paton JC,Kitamura M

Toxicol Sci   120   79 - 86   2010.12

Disruption of gap junction attenuates aminoglycoside-elicited renal tubular cell injury. Reviewed Major achievement

Jian YAO,Tao HUANG,X FANG,Y CHI,Y ZHU,Y WAN,H MATSUE,Masanori KITAMURA

Br J Pharmacol   160   2055 - 2068   2010.6

Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response: Reviewed Major achievement

Nakajima S,Saito Y,Takahashi S,Hiramatsu N,Kato H,Johno H,Yao J,Paton AW,Paton JC,Kitamura M

Biochem Biophys Res Commun   397   176 - 180   2010.5

Selective deletion of adipocytes, but not preadipocytes, by TNF-α via C/EBP- and PPARγ-mediated suppression of NF-κB. Reviewed Major achievement

Tamai M,Shimada T,Hiramatsu N,Hayakawa K,Okamura M,Tagawa Y,Takahashi S,Nakajima S,Yao J,Kitamura M

Lab Invest   in press   2010.5

Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis. Reviewed Major achievement

Tao HUANG,Y ZHU,X FANG,Y CHI,Masanori KITAMURA,Jian YAO

Cancer Sci   101   713 - 721   2010.3

ER stress depresses NF-κB activation in mesangial cells through preferential induction of C/EBPβ. Reviewed Major achievement

Hayakawa K,Nakajima S,Hiramatsu N,Okamura M,Huang T,Saito Y,Tagawa Y,Tamai M,Takahashi S,Yao J,Kitamura M

J Am Soc Nephrol   21   73 - 81   2010.1

Suppression of nephrin expression by TNF-α via interfering with the cAMP - retinoic acid receptor pathway. Reviewed Major achievement

Yukinori SAITO,Maro OKAMURA,Shotaro NAKAJIMA,Kunihiro HAYAKAWA,Tao HUANG,Jian YAO,Masanori KITAMURA

Am J Physiol-Renal   2010.1

Impairment of MCP-1 expression in mesothelial cells ezposed to PDF by osmotic stress and acidic stress. Reviewed Major achievement

Ryouji Ogata,Nobuhiko HIRAMATSU,Kunihiro HAYAKAWA,Shotaro NAKAJIMA,Jian YAO,T KOBAYASHI,Masanori KITAMURA

Perit Dial Int   2010.1

特集＜中国おける医師の偏在について＞あとがき Reviewed Major achievement

姚　建

日中医学   24 ( 5 )   62 - 62   2010.1

Impairment of MCP-1 Exposed to Peritoneal Dialysis Fluid By Osmotic Stress And Acidic Stress. Reviewed Major achievement

Ryouji Ogata,Nobuhiko　HIRAMATSU,Kunihiro HAYAKAWA,Shotaro NAKAJIMA,Jian YAO,Tetsuro KOBAYASHI,Masanori KITAMURA

Peritoneal Dialysis International   31   80 - 89   2009.12

Preferential blockade of dioxin-induced activation of the aryl hydrocarbon receptor by Antrodia camphorata. Reviewed Major achievement

Mai MUKAI,Kunihiro HAYAKAWA,Maro OKAMURA,Yasuhiro TAGAWA,Shotaro NAKAJIMA,Yukinori SAITO,Syuhei TAKAHASHI,Jian YAO,D NISHIMURA,M SUGI,M MATSUNAGA,Masanori KITAMURA

Biol Pharm Bull   32   1510 - 1515   2009.9

Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor. Reviewed Major achievement

Maro OKAMURA,Yosuke TAKANO,Yukinori SAITO,Jian YAO,Masanori KITAMURA

Nephrol Dial Transplant   24   3006 - 3012   2009.8

Downregulation of gap junction expression and function by endoplasmic reticulum stress. Reviewed Major achievement

Tao HUANG,Y WAN,Y ZHU,X FANG,Nobuhiko HIRAMATSU,Kunihiro HAYAKAWA,Aw PATON,JC PATON,Masanori KITAMURA,Jian YAO

J Cell Biochem   107   973 - 983   2009.8

Suppression of NF-κB by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family: Implication for unfolded protein response. Reviewed Major achievement

S DU,Nobuhiko HIRAMATSU,Kunihiro　HAYAKAWA,Ayumi KASAI,Maro OKAMURA,Tao HUANG,Jian YAO,Masayuki Takeda,Isao Araki,Norifumi SAWADA,Aw PATON,JC PATON,Masanori KITAMURA

J Immunol   182   7201 - 7211   2009.6

Activation of the Akt-NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. Reviewed Major achievement

H YAMAZAKI,Nobuhiko HIRAMATSU,Kunihiro HAYAKAWA,Yasuhiro TAGAWA,Maro OKAMURA,Ryouji Ogata,Tao HUANG,Shotaro NAKAJIMA,Jian YAO,Aw PATON,JC PATON,Masanori KITAMURA

J Immunol   183   1480 - 1487   2009.6

Dual suppression of adipogenesis by cigarette smoke through activation of the aryl hydrocarbon receptor and induction of endoplasmic reticulum stress Reviewed Major achievement

MUKAI,Jian YAO,Y FUJII-KURIYAMA,Masanori KITAMURA

Am J Physiol-Endocrinol and Metab   296   E721 - E730   2009.4

Acquisition of anergy to proinflammatory cytokines in non-immune cells through endoplasmic reticulum stress response: A mechanism for subsidence of inflammation. Reviewed Major achievement

Kunihiro　HAYAKAWA,Nobuhiko HIRAMATSU,Maro OKAMURA,H YAMAZAKI,Shotaro NAKAJIMA,Jian YAO,AW PATON,JC PATON,Masanori KITAMURA

J Immunol   182 ( 2 )   1182 - 1191   2009.1

Gap junctional intercellular communication in the juxtaglomerular apparatus. Reviewed Major achievement

Jian YAO,Takashi OITE,Masanori KITAMURA

Am J Physiol - Renal   296   F936 - F946   2009.1

Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response Reviewed Major achievement

Maro OKAMURA,Yosuke TAKANO,Nobuhiko HIRAMATSU,Kunihiro　HAYAKAWA,Jian YAO,Aw PATON,JC PATON,Masanori KITAMURA

Am J Physiol - Renal Physiol   295 ( 5 )   F1495 - F1503   2008.11

Blockade of the aryl hydrocarbon receptor pathway triggered by dioxin, polycyclic aromatic hydrocarbons and cigarette smoke by Phellinus linteus Reviewed Major achievement

Mai　MUKAI,Ayumi KASAI,Nobuhiko HIRAMATSU,Kunihiro　HAYAKAWA,Maro OKAMURA,Yasuhiro TAGAWA,Jian YAO,T NAKAMURA,Masanori KITAMURA

Biol Pharm Bull   31 ( 10 )   1888 - 93   2008.10

糸球体メサンギウム細胞の細胞特性 Reviewed Major achievement

姚　建,北村　正敬,追手　巍

日本腎臓学会誌   50   554 - 560   2008.10

Induction of apoptosis by cigarette smoke via ROS-dependent ER stress and CHOP Reviewed Major achievement

Yasuhiro TAGAWA,Kunihiro　HAYAKAWA,Maro OKAMURA,Jian YAO,Masanori KITAMURA

Free Radic Biol Med.   45 ( 1 )   50 - 59   2008.7

特集＜中国におけるスポーツ医学の現状＞ あと書き

姚　建

日中医学   23 ( 1 )   44 - 44   2008.5

Blockade of the dioxin pathway by herbal medicine Formula bupleuri minor: Identification of active entities for suppression of AhR activation Reviewed Major achievement

Ayumi KASAI,Nobuhiko HIRAMATSU,Kunihiro　HAYAKAWA,Jian YAO,Masanori KITAMURA

Biol Pharm Bull   31 ( 5 )   838 - 846   2008.5

Involvement of hypoxia-triggered endoplasmic reticulum stress in outlet obstruction-induced apoptosis in the urinary bladder Reviewed Major achievement

Norifumi SAWADA,Jian YAO,Nobuhiko Hiramatsu,Hayakawa Kunihiro,Isao Araki,Masayuki Takeda,Masanori KITAMURA

Laboratory Investgation   88   553 - 563   2008.5

Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrocarbons. Reviewed Major achievement

Ayumi KASAI,Nobuhiko HIRAMATSU,Kunihiro　HAYAKAWA,Jian YAO,Masanori KITAMURA

Environ Health Perspect   116   349 - 354   2008.3

Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response Reviewed Major achievement

Makiko YOKOUCHI,Nobuhiko HIRAMATSU,Kunihiro　HAYAKAWA,Maro OKAMURA,Shuqi DU,Ayumi KASAI,Yosuke TAKANO,Akihiro SHITAMURA,Tsuyoshi SHIMADA,Jian YAO,Masanori KITAMURA

J Biol Chem   283   4252 - 4260   2008.2

Blunted activation of NF-KB and NF-KB-dependent gene expression by geranylgeranylacetone: Involvement of unfolded protein response. Reviewed Major achievement

Kunihiro　HAYAKAWA,Nobuhiko HIRAMATSU,Maro OKAMURA,Jian YAO,AW PATON,JC PATON,Masanori KITAMURA

Biochem Biophys Res Commun   365 ( 1 )   47 - 53   2008.1

Unexpected blockade of adipocyte differentiation by K-7174: Implication for endoplasmic reticulum stress Reviewed Major achievement

Tsuyoshi SHIMADA,Nobuhiko HIRAMATSU,Maro OKAMURA,Kunihiro HAYAKAWA,Ayumi KASAI,Jian YAO,Masanori KITAMURA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   363 ( 2 )   335 - 360   2007.11

Geranylgeranylacetone, an inducer of HSP70, elicits unfolded protein response and coordinates cellular fate independently of HSP70 Reviewed Major achievement

Satoshi ENDO,Nobuhiko HIRAMATSU,Kunihiro HAYAKAWA,Maro OKAMURA,Ayumi KASAI,Yasuhiro TAGAWA,Norifumi SAWADA,Jian YAO,Masanori KITAMURA

MOLECULAR PHARMACOLOGY   72 ( 5 )   1337 - 1348   2007.11

Suppression of cytokine response by GATA inhibitor K-7174 via unfolded protein response Reviewed Major achievement

Yosuke TAKANO,Nobuhiko HIRAMATSU,Maro OKAMURA,Kunihiro HAYAKAWA,Tsuyoshi SHIMADA,Ayumi KASAI,Makiko YOKOUCHI,Akihiro SHITAMURA,Aw PATON,Jc PATON,Jian YAO,Masanori KITAMURA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   360 ( 2 )   470 - 475   2007.8

Connexin43 Reviewed Major achievement

63 ( 4 )   522 - 525   2007.8

Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response Reviewed Major achievement

Makiko YOKOUCHI,Nobuhiko HIRAMATSU,Kunihiro HAYAKAWA,Ayumi KASAI,Yosuke TAKANO,Jian YAO,Masanori KITAMURA

CELL DEATH AND DIFFERENTIATION   14 ( 8 )   1467 - 1474   2007.8

Irsogladine maleate potentiates the effects of nitric oxide on activation of cAMP signaling pathways and suppression of mesangial cell mitogenesis Reviewed Major achievement

Jian YAO,Ying Zhu,Wei SUN,Norifumi SAWADA,Nobuhiko HIRAMATSU,Masayuki TAKEDA,Masanori KITAMURA

BRITISH JOURNAL OF PHARMACOLOGY   151 ( 4 )   457 - 466   2007.6

Pathophysiological roles of gap junction in glomerular mesangial cells Major achievement

Jian YAO,Takashi OITE,Tetsuo MORIOKA,Masanori KITAMURA

J Membrane Biol   217 ( 1 )   123 - 130   2007.6

Rapid, transient induction of ER stress in the liver and kidney after acute exposure to heavy metal: Evidence from transgenic sensor mice Reviewed Major achievement

Nobuhiko HIRAMATSU,Ayumi KASAI,Shuqi DU,Masayuki TAKEDA,Kunihiro HAYAKAWA,Maro OKAMURA,Jian YAO,Masanori KITAMURA

FEBS LETTERS   581 ( 10 )   2055 - 2059   2007.5

Rapid ransient induction of ER stress in the liver and kidney after acute exposure to heavy metal: Evidence from transgenic sensor mice Reviewed Major achievement

Nobuhiko HIRAMATSU,Ayumi KASAI,Shiqi DU,Masayuki TAKEDA,Kunihiro　HAYAKAWA,Maro OKAMURA,Jian YAO,Masanori KITAMURA

FEBS Letters   581   2055 - 2059   2007.5

Recovery and maintenance of nephrin expression in cultured podocytes and identification of HGF as a repressor of nephrin Reviewed Major achievement

Yosuke TAKANO,Kozue YAMAUCHI,Nobuhiko HIRAMATSU,Ayumi KASAI,Kunihiro HAYAKAWA,Makiko YOKOUCHI,Jian YAO,Masanori KITAMURA

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   292 ( 5 )   F1573 - F1582   2007.5

Irsogladine maleate potentiates the effects of nitric oxide on activation of cAMP signalling pathways and suppression of mesangial cell mitogenesis Reviewed Major achievement

Jian YAO,Norifumi SAWADA,Masayuki Takeda,Masanori KITAMURA

Br J Pharmacol   151   457 - 466   2007.4

Smad4 is essential for down-regulation of E-cadherin induced by TGF in pancreatic cancer cell line PANC-1 Reviewed Major achievement

Yosuke TAKANO,F KANAI,A JAZAG,H IJICHI,Jian YAO,H OGAWA,Nobuyuki ENOMOTO,H OGAWA,A NAKAO

J Biochem (Tokyo)   141 ( 3 )   345 - 351   2007.3

慢性腎臓病に有効な中薬の作用機構 Major achievement

万　毅剛,姚　建

日中医学   21 ( 6 )   18 - 23   2007.3

特集 <中国における腎臓内科学の現状> あとがき Major achievement

姚　建

日中医学   21 ( 6 )   42 - 42   2007.3

Transcriptional suppression of nephrin in podocytes by macrophages: Roles of inflammatory cytokines and involvement of the PI3K/Akt pathway Reviewed Major achievement

Yosuke TAKANO,Kozue YAMAUCHI,Kunihiro HAYAKAWA,Nobuhiko HIRAMATSU,Ayumi KASAI,Maro OKAMURA,Makiko YOKOUCHI,Akihiro SHITAMURA,Jian YAO,Masanori KITAMURA

FEBS LETTERS   581 ( 3 )   421 - 426   2007.2

Secreted protein-based reporter systems for monitoring inflammatory events: Critical interference by endoplasmic reticulum stress. Reviewed Major achievement

Nobuhiko HIRAMATSU,Ayumi KASAI,Kunihiro HAYAKAWA,Kaoru NAGAI,T KUBOTA,Jian YAO,Masanori KITAMURA

JOURNAL OF IMMUNOLOGICAL METHODS   315   202 - 207   2006.10

Real-time detection and continuous monitoring of ER stress in vitro and in vivo by ES-TRAP: Evidence for systemic, transient ER stress during endotoxemia. Reviewed Major achievement

Nobuhiko HIRAMATSU,Ayumi KASAI,Kunihiro HAYAKAWA,Jian YAO,Masanori KITAMURA

NUCLEIC ACIDS RESEARCH   34   e93   2006.10

High levels of dioxin-like potential in cigarette smoke evidenced by in vitro and in vivo biosensing. Reviewed Major achievement

Ayumi KASAI,Nobuhiko HIRAMATSU,Kunihiro HAYAKAWA,Jian YAO,Syuichirou MAEDA,Masanori KITAMURA

CANCER RESEARCH   66   7143 - 7150   2006.9

Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes. Reviewed Major achievement

Kozue YAMAUCHI,Yosuke TAKANO,Ayumi KASAI,Kunihiro HAYAKAWA,Nobuhiko HIRAMATSU,Nobuyuki ENOMOTO,Jian YAO,Masanori KITAMURA

KIDNEY INTERNATIONAL   70   892 - 900   2006.8

Secreted protein-based reporter systems for monitoring inflammatory events: Critical interference by endoplasmic reticulum stress. Reviewed Major achievement

Nobuhiko HIRAMATSU,Ayumi KASAI,Kunihiro HAYAKAWA,Kaoru NAGAI,Jian YAO,Masanori KITAMURA

J. Immunol. Methods   315 ( 1-2 )   202 - 207   2006.8

Novel potential of tunicamycin as an activator of the aryl hydrocarbon receptor - dioxin responsive element signaling pathway. Reviewed Major achievement

K HORIKAWA,N OISHI,J NAKAGAWA,Ayumi KASAI,Kunihiro HAYAKAWA,Nobuhiko HIRAMATSU,Yosuke TAKANO,Makiko YOKOUCHI,Jian YAO,Masanori KITAMURA

FEBS LETTERS   580   3721 - 3725   2006.7

Profiling of functional phosphodiesterase in mesangial cells using a CRE-SEAP-based reporting system Reviewed Major achievement

Ying ZHU,Jian YAO,Yiman MENG,Ayumi KASAI,Nobuhiko HIRAMATSU,Kunihiro HAYAKAWA,Takashi MIIDA,Masayuki TAKEDA,Masahiko OKADA,Masanori KITAMURA

British Journal of Pharmacology   148   833 - 844   2006.7

Spontaneous activation of the NF-κB signaling pathway in isolated normal glomeruli. Reviewed Major achievement

Kunihiro HAYAKAWA,Yiman MENG,Nobuhiko HIRAMATSU,Ayumi KASAI,Jian YAO,Masanori KITAMURA

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   291   F1169 - F1176   2006.6

Turbulence of glomerular hemodynamics involved in progressive glomerulosclerosis. Reviewed Major achievement

Kawamura K, Okada S, Li B, Suwa M, Yao J, Morioka T, Gejyo F, Oite T

Kidney Int   69 ( 10 )   1792 - 1798   2006.5

Synergistic effects of PDGF-BB and cAMP-elevating agents on expression of connexin43 in mesangial cells Reviewed Major achievement

Jian YAO,Masanori KITAMURA,Ying ZHU,Yiman MENG,Ayumi KASAI,Nobuhiko HIRAMATSUE,Tetsuo MORIOKA,Masayuki TAKEDA,Takashi OITE

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   290 ( 5 )   1083 - 1093   2006.5

Turbulence of glomerular hemodynamics involved in progressive glomerulosclerosis Reviewed Major achievement

K KAWAMURA,S OKADA,Bing LI,Michihiro SUWA,Jian YAO,Tetsuo MORIOKA,F GEJIO,Takashi OITE

KIDNEY INTERNATIONAL   69   1792 - 1798   2006.4

Priming of glomerular mesangial cells by activated macrophages causes blunted responses to proinflammatory stimuli Reviewed Major achievement

Kunihiro HAYAKAWA,Yiman MENG,Nobuhiko HIRAMATSUE,Ayumi KASAI,Kozue YAMAUCHI,Jian YAO,Masanori KITAMURA

JOURNAL OF IMMUNOLOGY   176 ( 4 )   2529 - 2537   2006.2

Influence of cAMP on reporter bioassays for dioxin and dioxin-like compounds Reviewed Major achievement

TOXICOLOGY AND APPLIED PHARMACOLOGY   211   11 - 19   2006.2

Gap junction-mediated intercellular communication between dendritic cells (DCs) is required for effective activation of DCs. Reviewed Major achievement

Hiroyuki MATSUE,Jian YAO,Keiko MATSUE,Akiko NAGASAKA,Hideaki SUGIYAMA,Rui Aoki,Masanori KITAMURA,Shinji SHIMADA

JOURNAL OF IMMUNOLOGY   176 ( 1 )   181 - 190   2006.1

Bioassay-based screening of microorganisms that degrade dioxin using substrate-immobilized microtubes Reviewed Major achievement

Akihiro SHITAMURA,Ayumi KASAI,Nobuhiko HIRAMATSUE,Kunihiro HAYAKAWA,Jian YAO,Masanori KITAMURA

ANALYTICAL BIOCHEMISTRY   347   135 - 143   2005.12

Continuous, noninvasive monitoring of local microscopic inflammation using a genetically enginerred cell-based biosensor Reviewed Major achievement

Yiman MENG,Ayumi KASAI,Nobuhiko HIRAMATSU,Kunihiro HAYAKAWA,Kozue YAMAUCHI,Masayuki TAKEDA,Hiroshi KAWACHI,Fujio SHIMIZU,Jian YAO,Masanori KITAMURA

LABORATORY INVESTIGATION   85   1429 - 1439   2005.11

Enhancement of NF-kB activity by resveratrol in cytokine-exposed mesangial cells Reviewed Major achievement

Yoshihito UCHIDA,Hiroyuki YAMAZAKI,Shinta WATANABE,Kunihiro HAYAGAWA,Yiman MENG,Nobuhiko HIRAMATSU,Ayumi KASAI,Kozue YAMAUCHI,Jian YAO,Masanori KITAMURA

CLINICAL AND EXPERIMENTAL IMMUNOLOGY   142   76 - 83   2005.8

Real-time monitoring of mesangial cell-macrophage cross-talk using SEAP in vitro and ex vivo Reviewed Major achievement

Yiman MENG,Ayumi KASAI,Nobuhiko HIRAMATSUE,Kunihiro HAYAKAWA,Hiroshi KAWACHI,Masayuki TAKEDA,Fujio SHIMIZU,Jian YAO,Masanori KITAMURA

KIDNEY INTERNATIONAL   68 ( 2 )   886 - 893   2005.8

Bone marrow cells contribute to regulation of damaged glomerular endothelial cells Reviewed Major achievement

Kozo IKARASHI,Bing LI,Michihiro SUWA,Kazuko KAWAMURA,Tetsuo MORIOKA,Jian YAO,Fahima KHAN,Makoto UCHIYAMA,Takashi OITE

KIDNEY INTERNATIONAL   67 ( 5 )   1925 - 1933   2005.5

Alkaline phosphatase vs. luciferase as secreted reporter molecules in vivo. Reviewed Major achievement

Nobuhiko HIRAMATSUE,Ayumi KASAI,Yiman MENG,Kunihiro HAYAKAWA,Jian YAO,Masanori KITAMURA

ANALYTICAL BIOCHEMISTRY   339   249 - 256   2005.4

Nitric oxide-mediated regulation of connexin43 expression and gap junctional intercellular communication in mesangial cells Reviewed Major achievement

Jian YAO,Nobuhiko HIRAMATSUE,Ying ZHU,Tetsuo MORIOKA,Masayuki TAKEDA,Takashi OITE,Masanori KITAMURA

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   16   58 - 67   2005.1

Fast-track DRESSA: A bioassay for fast, sensitive and selective detection of halogenated and polycyclic aromatic hydrocarbons Reviewed Major achievement

Ayumi KASAI,Yiman MENG,Nobuhiko HIRAMATSUE,Jian YAO,Shuichiro MAEDA,Masanori KITAMURA

ANALYTICAL BIOCHEMISTRY   337   84 - 88   2005.1

Establishment of immortalized human glomerular endothelial cell lines and their application. Reviewed Major achievement

T HARADA,S BATSFORD,Tetsuo MORIOKA,Jian YAO,M ARAKAWA,F GEJYO,Takashi OITE

NEPHRON EXPERIMENTAL NEPHROLOGY   99 ( 2 )   38 - 45   2005.1

_biosensing of dioxin and dioxin-like chemicals using secreted alkaline phosphatase Reviewed Major achievement

Ayumi　KASAI,Nobuhiko HIRAMATSU,Yiman MENG,Jian YAO,Masayuki TAKEDA,Shuichiro MAEDA,Masanori KITAMURA

ANALYTICAL BIOCHEMISTRY   335   73 - 80   2004.12

The characterization of a specific Thy-1 molecular epitope expressed on rat mesangial cells Reviewed Major achievement

Tetsuo MORIOKA,Jian YAO,Y SUZUKI,Takashi OITE

KIDNEY INTERNATIONAL   66   2214 - 2223   2004.12

Real-time observation of glomerular hemodynamic changes in diabetic rats: effects of insulin and ARB. Reviewed Major achievement

Bin LI,Jian YAO,K KAWAMURA,Y OYANAGI-TANAKA,M HOSHIYAMA,Tetsuo MORIOKA,F GEJYO,M UCHIYAMA,Takashi OITE

KIDNEY INTERNATIONAL   66   1939 - 1948   2004.11

Genetic biosensor: Application for medicine, ecomanagement, and in vivo bioimaging Reviewed Major achievement

Masanori KITAMURA,Ayumi KASAI,Yiman MANG,Nobuhiko HIRAMATSU,Jian YAO

Recent Res Devel Biophys Biochem   4   1 - 13   2004.10

AP-1-independent sensitization to oxidative stress-induced apoptosis by proteasome inhibitors. Reviewed Major achievement

Nobuhikou HIRAMATSU,Ayumi KASAI,Jian YAO,Yiman MENG,Masayuki TAKEDA,Shuichiro MAEDA,Masanori KITAMURA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   316 ( 2 )   545 - 552   2004.4

Cellular defense against H202-induced apoptosis via MAP kinase-MKP-1 pathway. Reviewed Major achievement

Cazana J,Ishikawa Y,LG FINE,Jian YAO,Masanori KITAMURA

FREE RADICAL BIOLOGY AND MEDICINE   36   985 - 993   2004.1

Effect of high glucose on nitric oxide produciton and endothelial nitric oxide synthase protein expression in human glomerular endothelial cells Reviewed Major achievement

Hoshiyama M,Li B,Jian YAO,Harada T,Morioka T,Oite T

Nephron Exp Nephrol   95   62 - 68   2003.12

Different expression patterns of Bcl-2, Bcl-xl, and Bax proteins after sublethal forebrain ischemia in C57Black/Crj6 mouse striatum Reviewed Major achievement

Wu C,Fujihara H,Jian YAO,Qi S,Li H,Shimoji K,Baba H

Stroke   34   1803 - 1880   2003.10

ATP-dependent mechanism for coordination of intercellular cacium signaling and renin secretion in rat juxtaglomerular cells Reviewed Major achievement

Jian YAO,M Suwa,Bing Li,K Kawamura,Tetsuo Morioka,Takashi Oite

Circ Res   93 ( 93 )   338 - 345   2003.10

Disturbance of syncytial cell function in glomerular mesangial cells involved in the progressive glomerular diseases Reviewed Major achievement

Takashi Oite,Jian YAO,tetsuo Morioka

Contrib Nephrol   139   12 - 19   2003.5

Up-regulation of connexin43 in glomerular podocytes in response to injury Reviewed Major achievement

Yaoita E, Yao J, Yoshida Y, Morioka T, Nameta M, et al (5)

Am J Pathol   161 ( 5 )   1597 - 1606   2002.11

Coordination of mesangial cell contraction by gap junction-mediated intercellular Ca2+ wave Reviewed Major achievement

Yao J, Morioka T, Li B, Oite T

J Am Soc Nephrol   13 ( 8 )   2018 - 2026   2002.8

Impairment of vascular regeneration proceeds progressive glomerulosclerosis in anti Thy-1 glomerulonephritis Reviewed Major achievement

Wada Y, Morioka T, Oyanagi-Tanaka Y, Yao J, Suzuki Y, Gejyo F, Arakawa M, Oite T

Kidney Int   61 ( 2 )   432 - 443   2002.2

Nitric oxide increases albumin permeability of isolated rat glomeruli via phosphorylation-dependent mechanism Reviewed Major achievement

Li B, Yao J, Morioka T, Oite T

J Am Soc Nephrol   12 ( 12 )   2616 - 2624   2001.12

Endothelin is a potent inhibitor of matrix metalloprotease-2 secretion and activation in rat mesangial cells Reviewed Major achievement

Yao J, Morioka T, Li B, Oite T

Am J Physiol Renal Physiol   280 ( 4 )   F628 - F635   2001.4

Real time observation of hemodynamic changes in glomerular aneurysms induced by anti-Thy-1 antibody Reviewed Major achievement

Oyanagi-Tanaka Y, Yao J, Wada Y, Morioka T, Suzuki Y, Gejyo F, Arakawa M, Oite

Kidney Int   59 ( 1 )   252 - 259   2001.1

TNBS誘発マウス大腸炎におけるギャップ結合タンパク質コネキシン43の役 割 Major achievement

Qiaojing Yan, Jian Yao

第44回日本分子生物学会年会  2021.12 

Regulation of Antibody Activity by Pro- and Anti-oxidants via Modification of the Disulfide Bonds in Antibody Structure International conference

Xiawen Yang and Jian Yao

The 27th Annual Conference of the Society for Redox Biology and Medicine  2020.11  the Society for Redox Biology and Medicine

Hydrogen Sulfide Is an Endogenous Scavenger of Lipid Oxidation Product Acrolein International conference

Zhimin Mao, Jian Yao

The 27th Annual Conference of the Society for Redox Biology and Medicine  2020.11  the Society for Redox Biology and Medicine

Hydrogen Sulfide Is an Endogenous Scavenger of Lipid Oxidation Product Acrolein International conference

Zhimin Mao, Jian Yao

The 27th Annual Conference of the Society for Redox Biology and Medicine  2020.11  the Society for Redox Biology and Medicine

Regulation of Antibody Activity by Pro- and Anti-oxidants via Modification of the Disulfide Bonds in Antibody Structure International conference

Xiawen Yang, Jian Yao

The 27th Annual Conference of the Society for Redox Biology and Medicine  2020.11  the Society for Redox Biology and Medicine

Hydrogen Sulfide Determines Tumor Cell Sensitivity to Thioredoxin Inhibitor PX-12 International conference

Zhimin Mao, Jian Yao

SfRBM2019  2019.11  SfRBM

Hydrogen Sulfide Determines Tumor Cell Sensitivity to Thioredoxin Inhibitor PX-12 International conference

Zhimin Mao, Jian Yao

SfRBM2019  2019.11  SfRBM

Role of Gap junctions in inflammasome activation and inflammatory renal diseases International conference Major achievement

Jian YAO

第一届大连免疫和代谢性肾脏病专题研讨会  2019.8 

Connexin43 regulates inflammasome activation and inflammatory cell injury through modulation of NADPH Oxidase-dependent redox signaling pathway International conference

Yanru Huang, Zhimin Mao, Xiawen Yang, Jian Yao

International Gap Junction Conference 2019  2019.7  Gap junction conference

Connexin43 regulates inflammasome activation and inflammatory cell injury through modulation of NADPH Oxidase-dependent redox signaling pathway International conference

Yanru Huang, Zhimin Mao, Xiawen Yang, Jian Yao

International Gap Junction Conference 2019  2019.7  Gap junction conference

Hydrogen sulfide inhibits adramycin-initiated glomerular pococyte injury via interference of Trx/ASK1/P38 signaling International conference

Jian YAO

ISN world conference of nephrology  2019.4  International society of nephrology

Hydrogen sulfide inhibits adramycin-initiated glomerular pococyte injury via interference of Trx/ASK1/P38 signaling International conference

Jian YAO

ISN world conference of nephrology  2019.4  International society of nephrology

Hydrogen sulfide counteracts angiotensin II-stimulated glomerular mesangial proliferation and matrix production via multiple mechanisms International conference Major achievement

Zhen Zhang, Jian Yao

25th annual conference of SFRBM (society for free radical and biological medicine)  2018.11  SFRBM

Connexin43 regulates inflammasome activation and LPS-initiated acute renal injury via modulation of cellular oxidative status International conference Major achievement

Yanru Huang, Zhimin Mao, Jian Yao

25th annual conference of SFRBM (society for free radical and biological medicine)  2018.11  SFRBM

Hydrogen sulfide protects cells against oxidative stress through modifying the redox status of thioredoxin International conference Major achievement

Zhimin Mao, Jian Yao

25th annual conference of SFRBM (society for free radical and biological medicine)  2018.11  SFRBM

Connexin43 regulates inflammasome activation and LPS-initiated acute renal injury via modulation of cellular oxidative status International conference

Yanru Huang, Zhimin Mao, Jian Yao

25th annual conference of SFRBM (society for free radical and biological medicine)  2018.11  SFRBM

Hydrogen sulfide protects cells against oxidative stress through modifying the redox status of thioredoxin International conference

Zhimin Mao, Jian Yao

25th annual conference of SFRBM (society for free radical and biological medicine)  2018.11  SFRBM

Hydrogen sulfide counteracts angiotensin II-stimulated glomerular mesangial proliferation and matrix production via multiple mechanisms International conference

Zhen Zhang, Jian Yao

25th annual conference of SFRBM (society for free radical and biological medicine)  2018.11  SFRBM

Gap junction-mediated regulation of redox signaling and oxidative cellular responses Invited Major achievement

Yao Jian

ConBio2017  2017.12 

Gap junction-mediated regulation of redox signaling and oxidative cellular responses Invited

Yao Jian

ConBio2017  2017.12  日本分子生物学会

Hydrogen sulfide inhibits antibody- and complement-mediated immune responses via S-sulfhydration International conference Major achievement

Zhen Zhang, Xiawen Yang, and Jian Yao

24th Annual Meeting of Free Radical Biology & Medicine  2017.11  American Society for Free Radical and Biological Medicine

Hydrogen sulfide inhibits antibody- and complement-mediated immune responses via S-sulfhydration International conference

Zhen Zhang, Xiawen Yang, Jian Yao

24th Annual Meeting of Free Radical Biology & Medicine  2017.11  American Society for Free Radical and Biological Medicine

Glutathione inhibits antibody-initiated and complement-dependent lysis of　glomerular mesangial cells via multiple mechanisms Major achievement

Zhen Zhang; Jian Yao

60th Annual Meeting of the Japanese Society of Nephrology  2017.5 

The pivotal role of TRPV4 and Connexin43 channel transactivation in mediation of aminoglycoside-elicited renal tubular cell injury Major achievement

Xiling Zhang; Jian Yao

60th Annual Meeting of the Japanese Society of Nephrology  2017.5 

Pannexin channels contribute to air exposure-elicited oxidative injury in　bronchial epithelial cells.

Yanru Huang, Xiling Zhang, Zhen Zhang, Shan Gao, Xin Fang, Jian Yao.

2016.11 

Connexin43 channel contributes to TRPV4 activation-elicited oxidative cell injury.

Xiling Zhang, Manabu Kamiyama, Zhen Zhang, Yanru Huang, Shan Gao, Xin Fang, Masayuki Takeda, Jian Yao.

2016.11 

TXNIP Contributes to Gap Junction-Mediated Regulation of Glucose Transporter-1 Expression and Oxidative Cell Injury

2015.12 

Pathophysiological Roles of Gap Junction-Mediated Intercellular Communication in Kidney Major achievement

2015.12 

Connexin43 hemichannels contribute to air exposure-elicited oxidative cell injury

2015.12 

Regulation of Tight Junction and Adherent Junction Disassembly by Connexin43 Hemichannels Major achievement

FASEB J  2015.4 

Pathophysiological roles of gap junction-mediated intercellular communication in kidney Major achievement

Nanjing International forum 2014-nephrology update in traditional Chinese medicine  2014.12 

P53-mediated upregulation of MKP-3 contributes to the maintenance of cellular senescent phenotype through dephosphorylation of ERK1/2 Major achievement

2014.11 

Regulation of tight junction disassembly by gap junction hemichannels Major achievement

2014.11 

MP24-19 CONNEXIN 43 SENSITIZES PROSTATE CANCER CELLS TO THIOREDOXIN INHIBITOR PX12-INDUCED APOPTOSIS

The journal of urology  2014.5 

INHIBITION OF GAP JUNCTIONS PROTECTS RENAL CELLS AGAISNT NEPHROTOXIC DRUG-INDUCED CELL INJURY Major achievement

The 14th Asian Pacific Congress of Nephrology 2014 in Tokyo  2014.5 

AMPK Protects podocytes from Adriamycin-elicited Injury. Major achievement

2014.3 

Purinergic control of AMPK activation by ATP released through connexin43 hemichannels: pivotal roles in hemichannel-mediated disassembly of tight junction and cell injury Major achievement

International Gap Junction Conference 2013  2013.6 

Activation of AMPK Protects podocytes from Adriamycin-elicited Injury. Major achievement

2013.5 

Connexin43 hemichannel-mediated release of ATP suppresses AMPK activation in renal tubular epithelial cells Major achievement

2012.11 

BETA-CATENIN SIGNALING CONTRIBUTES TO PDGF-ELICITED BLADDER SMOOTH MUSCLE CELL CONTRACTION THROUGH UPREGULATION OF CX43 EXPRESSION Major achievement

42nd Annual Meeting of the International Continence Society(ICS)  2012.10 

NADPH oxidase-mediated up-regulation of connexin43 contributes to the oxidative stress-elicited podocyte injury. Major achievement

Gao K, ,Yan Q, ,Chi Y, ,Sun W, ,Kitamura M, ,Yao J

2012.6  日本腎臓学会

β-catenin signaling PDGF-elicited bladder smooth muscle cell contraction through upregulation of Cx43 expression. Major achievement

The 107th Annual Meeting of The American Urological Association  2012.5 

PP-0593 β-cateninを介したシグナル伝達はPDGFによって惹起されたCx43の発現増加を介して起こる膀胱平滑筋細胞の収縮に関与している Major achievement

宮本　達也,李　凱,姚　建,澤田　智史,中込　宙史,井原　達矢,吉良　聡,今井　佑樹,北村　正敬,武田　正之

第100回日本泌尿器科学会総会  2012.4 

Connexin43 contributes to puromycin-elicited podocyte injury

Yan Q,Chi Y,Zhu Y,Kitamura M,Yao J

第34回日本分子生物学会年会  2011.12  日本分子生物学学会

Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase Major achievement

Chi Y,Yan Q,Li K,Takahashi S,Kitamura M,Yao J

第34回日本分子生物学会年会  2011.12 

腎細胞傷害に於けるギャップ結合を介した細胞間コミュニケーションの役割 Major achievement

Yao J

２０１１年国際中西医結合腎臓病学学術会議  2011.11 

Connexin43 contributes to puromycin-elicited podocyte injury Major achievement

Yan QJ,Chi Y,Zhu Y,Kitamura M,Yao J

44th Annual Meeting of The American Society of Nephrology  2011.11  American society of Nephrology

Suppression of inflammatory cytokines-triggered NFκB activation and iNOS expression in renal tubular cells by gap junction inhibitor flufenamic acid: a critical involvement of AMPK Major achievement

Chi Y,Yan QJ,Zhu Y,Kitamura M,Yao J

44th Annual Meeting of The American Society of Nephrology  2011.11  American society of Nephrology

Dysfunction of gap junctions stimulates COX-2 expression in juxtaglomerular renin-secreting cells

Yao J,Zhu Y,Kitamura M

44th Annual Meeting of The American Society of Nephrology  2011.11  American society of Nephrology

炎症誘発性サイトカインは膀胱平滑筋においてCx43の発現を増強し、ギャップジャンクションを介した細胞間伝達を促進する Major achievement

李　凱,姚　建,吉良　聡,中込　宙史,宮本　達也,澤田　智史,小林　英樹,土田　孝之,北村　正敬,武田　正之

第18回日本排尿機能学会  2011.9 

PROINFLAMMATORY CYTOKINES UPREGULATE CONNEXIN43 EXPRESSION AND PROMOTE GAP JUNCTION INTERCELLULAR COMMUNICATION IN BLADDER SMOOTH MUSCLE CELLS. Major achievement

LI Kai,Jian YAO,Norifumi SAWADA,Hiroshi Nakagomi,Tatsuya Miyamoto,Satoru Kira,Hideki Kobayashi,Takayuki Tsuchida,Masanori KITAMURA

International Continence Society 2011  2011.9 

Connexin43 hemichannels exaggerate cadmium-induced oxidative stress and cell injury in renal tubular epithelial cells (43rd Annual Meeting of the Americal Society of Nephrology) Major achievement

Yao J,Sun W,Huang T,Nakajima S,Kitamura M

2010.11  American Society of Nephorlogy

Connexin hemichannels mediate low calcium-elicited activation of cAMP signaling pathway and elevation of renin production in juxtaglomerular cells (43rd Annual Meeting of the Americal Society of Nephrology) Major achievement

Huang T,Nakajima S,Kitamura M,Yao J

2010.11  American Society of Nephrology

Pathophysiological roles of gap junction-mediated intercellular communication in kidney . Major achievement

Yao J

2010.9  南京中医薬大学

GPJ4:Platelet derived growth factor-mediated upregulation of connexin 43 in bladder smooth mscle cells: A possible role in urinary bladder overactivity Major achievement

Norifumi SAWADA,LI Kai,Jian YAO,Hiroshi Nakagomi,Tatsuya Miyamoto,Satoru Kira,Hideki Kobayashi,Takayuki Tsuchida,Masanori KITAMURA,Masayuki Takeda

The 5th Pan-Pacific Contience Society Meeting  2010.9 

MP5:Upregulation of connexion 43 expression and function in urinary bladder by inflammatory cytokines Major achievement

LI Kai,Norifumi SAWADA,Jian YAO,Hiroshi Nakagomi,Tatsuya Miyamoto,Satoru Kira,Hideki Kobayashi,Takayuki Tsuchida,Masanori KITAMURA,Masayuki Takeda

The 5th Pan-Pacific Continence Society Meeting  2010.9 

Participation of gap junction hemichannel in low calcium-elicied renin synthesis and secretion

Huang T,Chi Y,Fan X,Zhu Y,Kitamura M,Yao J

2010.6  第53回日本腎臓学会総会

膀胱の伸展と膀胱平滑筋細胞に対するPDGFおよびcAMPのCx43発現の相乗効果の関連について Major achievement

澤田　智史,姚　建,平松　伸彦,早川　国宏,座光寺　秀典,小林　英樹,望月　勉,北村　正敬,荒木　勇雄,武田　正之

第16回日本排尿機能学会  2009.9 

PDGF-mediated regulation of connexin43 expression in bladder smooth muscle cells Major achievement

Norifumi SAWADA,Jian YAO,Nobuhiko HIRAMATSUE,Hideki Kobayashi,Hidenori Zakoji,Tsutomu Mochizuki,Masanori KITAMURA,Isao Araki,Masayuki Takeda

The 4th Pan-Pacific Continence Society Meeting  2009.9 

腎臓における細胞間コミュニケーションの役割 Major achievement

姚　建

細胞間接着がもたらす細胞特性  2009.7  新潟大学

Endoplasmic reticulum stress regulates gap junction expression and function in glomerular mesangial cells Major achievement

Huang T, Zhu Y, Wan Y, Hiramatsu N, Paton AW, Paton JC, Kitamura M, and Yao J

第52回日本腎臓学会総会  2009.6  日本腎臓学会

Gap junction renders renal tubular cells vulnerable to cadmium-induced injury Major achievement

Fang X, Huang T, Zhu Y, Kitamura M, and Yao J

第52回日本腎臓学会総会  2009.6  日本腎臓学会

Hayakawa K, Du S, Hiramatsu N, Kasai A, Okamura M, Huang T, Yao J, Sawada N, Takeda M, and Kitamura M: Suppression of NF-?B by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family: Implication for unfolded protein response. Major achievement

早川　国宏,Shuqi DU,平松　伸彦,河西　あゆみ,岡村 麻呂,黄　涛,姚　建,澤田　智史,武田　正之,北村　正敬

第31回日本分子生物学会年会/第81回日本生化学会大会合同大会  2008.12 

Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrocarbons Major achievement

北村　正敬,河西　あゆみ,平松　伸彦,早川　国宏,姚　建

第31回日本分子生物学会年会/第81回日本生化学会大会合同大会  2008.12 

Induction of apoptosis by cigarette smoke via ROS-dependent ER stress and CHOP Major achievement

田川　泰寛,平松　伸彦,河西　あゆみ,早川　国宏,岡村 麻呂,姚　建,北村　正敬

第31回日本分子生物学会年会/第81回日本生化学会大会合同大会  2008.12 

Participation of gap junction in proteasome inhibition-induced cell damage Major achievement

Tao HUANG,Masanori KITAMURA,Jian YAO

第31回日本分子生物学会年会/第81回日本生化学会大会合同大会  2008.12 

Kitamua M, Du S, Hiramatsu N, Hayakawa K, Okamura M, Huang T, Yao J, and Takeda M: Suppression of NF-?B by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family: Implication for unfolded protein response. Major achievement

Masanori KITAMURA,Shuqi DU,Nobuhiko HIRAMATSUE,Kunihiro HAYAKAWA,Maro OKAMURA,Tao HUANG,Jian YAO,Masayuki TAKETA

41st Annual Meeting of The American Society of Nephrology  2008.11 

Blunted responses of mesothelial cells to inflammatory stimuli in peritoneal dialysis fluid: Roles of unfolded protein response-dependent and -independent pathways Major achievement

Ryoji OGATA,Nobuhiko HIRAMATSUE,Kunihiro HAYAKAWA,Jian YAO,Tetｓuro　KOBAYASHI,Masanori KITAMURA

41st Annual Meeting of The American Society of Nephrology  2008.11 

Sodium 4-Phenylbutyrate protects against hypoxic injury to bladder smooth muscle cell Major achievement

Norifumi SAWADA,Jian YAO,Nobuhiko HIRAMATSUE,Kunihiro HAYAKAWA,Isao Araki,Masayuki Takeda,Masanori KITAMURA

The 3rd Pan-Pacific Continence Society Meeting  2008.9 

急性尿閉モデルにおける膀胱平滑筋のアポトーシスに対する小胞体ストレス緩和薬(4-PBA)の救済効果 Major achievement

澤田　智史,姚　建,平松　伸彦,早川　国宏,座光寺　秀典,小林　英樹,望月　勉,荒木　勇雄,武田　正之,北村　正敬

第15回日本排尿機能学会  2008.9 

Induction of apoptosis by cigarette smoke via ROS-dependent ER stress and CHOP Major achievement

田川　泰寛,平松　伸彦,河西　あゆみ,早川　国宏,岡村 麻呂,姚　建,北村　正敬

The Japan-Korea Joint Seminar  2008.9 

緒方亮二、平松伸彦、姚建、小林哲郎、北村正敬: 腹膜透析液による中皮細胞のケモカイン発現阻害 Major achievement

緒方 亮二,平松　伸彦,姚　建,小林　哲郎,北村　正敬

第53回日本透析医学会学術集会・総会  2008.6 

Gap junction-mediated intercellular communication in renal circulation Major achievement

Jian YAO

中国中西医結合学会微循環学術大会  2008.6 

ヒト糸球体内皮細胞のGAP結合細胞間連絡に対するLPS,TNF-a,IFN-rの及ぼす影響について Major achievement

森岡哲夫,Fadial KAMAL,朴紅蘭,佐藤　綾子,姚　建,追手　巍

第51回日本腎学会学術総会  2008.6 

Gap junction renders renal tubular cell vulnerable to amino-glycosides-induced cytotoxicity Major achievement

姚　建,黄　涛,平松　伸彦,北村　正敬

第51回日本腎学会学術総会  2008.6 

閉塞膀胱における小胞体ストレスと平滑筋細胞の小胞体ストレスを介したアポトーシスの経路の探究 Major achievement

澤田　智史,姚　建,平松　伸彦,早川　国宏,座光寺　秀典,小林　英樹,望月　勉,荒木　勇雄,武田　正之,北村　正敬

第96回日本泌尿器科学会総会  2008.4 

A novel target for BOO-induced bladder dysfunction Major achievement

Norifumi SAWADA,Jian YAO,Nobuhiko HIRAMATSUE,Kunihiro HAYAKAWA,Hidenori Zakoji,Hideki Kobayashi,Tsutomu Mochizuki,Isao Araki,Masayuki Takeda,Masanori KITAMURA

23rd Annual EAU Congress  2008.3 

Gap junction propagates and amplifies aminoglycosides-induced cell death in renal tubular epithelial cells Major achievement

姚　建,黄　涛,Ying ZHU,平松　伸彦,澤田　智史,北村　正敬

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会  2007.12 

Suppression of cytokine response in podocytes by indomethacin: Involvement of unfolded protein response Major achievement

岡村 麻呂,高野　洋介,平松　伸彦,早川　国宏,河西　あゆみ,姚　建,北村　正敬

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会  2007.12 

Disruption of gap junctional intercellular communication by endoplasmic reticulum stress Major achievement

Tao HUANG,Ying ZHU,Nobuhiko HIRAMATSUE,Norifumi SAWADA,Masanori KITAMURA,Jian YAO

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会  2007.12 

Acquisition of anergy in non-immune cells to proinflammatory stimuli through endoplasmic reticulum stress response: A novel mechanism for subsidence of inflammation Major achievement

早川　国宏,平松　伸彦,河西　あゆみ,横内　万貴子,高野　洋介,岡村 麻呂,島田 剛,姚　建,北村　正敬

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会  2007.12 

Anti-inflammatory potential of cyclosporine A and tacrolimus (FK506) via induction of unfolded protein response Major achievement

北村　正敬,Shuqi DU,平松　伸彦,早川　国宏,河西　あゆみ,岡村 麻呂,島田 剛,姚　建,武田　正之,澤田　智史

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会  2007.12 

Rapid, transient induction of ER stress in the liver and kidney after acute exposure to heavy metal: Evidence from transgenic sensor mice Major achievement

河西　あゆみ,平松　伸彦,Shuqi DU,武田　正之,早川　国宏,岡村 麻呂,姚　建,北村　正敬

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会  2007.12 

Unexpected blockade of adipocyte differentiation by GATA inhibitor K-7174: Implication for endoplasmic reticulum stress Major achievement

島田 剛,平松　伸彦,早川　国宏,岡村 麻呂,河西　あゆみ,姚　建,北村　正敬

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会  2007.12 

Involvement of hypoxia-triggered endoplasmic reticulum stress in outlet obstruction-induced apoptosis in the urinary bladder Major achievement

Norifumi SAWADA,Jian YAO,Nobuhiko HIRAMATSUE,Kunihiro HAYAKAWA,Isao ARAKI,Masayuki TAKEDA,Masanori KITAMURA

The 2nd Pan-Pacific continence society meeting  2007.10 

閉塞膀胱における小胞体ストレスと平滑筋細胞のアポトーシス Major achievement

澤田　智史,姚　建,平松　伸彦,早川　国宏,座光寺　秀典,小林　英樹,望月　勉,荒木　勇雄,武田　正之,北村　正敬

第14回日本排尿機能学会  2007.10 

閉塞膀胱における小胞体ストレスと平滑筋細胞のアポトーシス

澤田智史,姚建,平松伸彦,早川国宏,座光寺秀典,小林英樹,望月勉,荒木勇雄,武田正之,北村正敬

第14回日本排尿機能学会  2007.10 

Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrocarbons Major achievement

河西　あゆみ,平松　伸彦,早川　国宏,岡村 麻呂,島田 剛,姚　建,北村　正敬

Dioxin 2007  2007.9 

Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrocarbons

Kasai A,Hiramatsu N,Hayakawa K,Okamura M,Shimada T,Yao J,Kitamura M

Dioxin 2007  2007.9 

生体内小胞体ストレスの非侵襲的・継続的なモニタリングシステムES-TRAP法の開発 Major achievement

平松　伸彦,早川　国宏,岡村 麻呂,島田 剛,緒方 亮二,澤田　智史,姚　建,北村　正敬

第30回日本基礎老化学会  2007.6 

生体内小胞体ストレスの非侵襲的・継続的なモニタリングシステムES-TRAP法の開発

平松伸彦,早川国宏,岡村麻呂,島田剛,緒方亮二,澤田智史,姚建,北村正敬

第30回日本基礎老化学会  2007.6 

Irsoglandine maleate potentistes the effects of nitric oxide on activation of cAMP signalin pathway and suppression of mesangial cell mitogenesis Major achievement

Jian YAO,Ying ZHU,N SAWADA,Nobuhiko HIRAMATSUE,Masanori KITAMURA

第50回日本腎臓学会学術総会  2007.5 

Irsoglandine maleate potentistes the effects of nitric oxide on activation of cAMP signalin pathway and suppression of mesangial cell mitogenesis

Yao J,Zhu Y,Sawada N,Hiramatsu N,Kitamura M

第50回日本腎臓学会学術総会  2007.5 

Dendritic cell(DC)-DC intercellular communications via GAP junctions are required for T cell activation Major achievement

Hiroyuki MATSUE,Jian YAO,Keiko MATSUE,Akiko NAKASAKA,Hideaki SUGIYAMA,Rui AOKI,Masanori KITAMURA,Shinji SHIMADA

日本研究皮膚科学会第32回学術大会・総会  2007.4 

Identification of hepatocyte growth factor as a repressor of nephrin gene expression using an optimum condition for cultured podocytes Major achievement

Yosuke TAKANO,Kotuse YAMAUCHI,Nobuhiko HIRAMATSU,Ayumi KASAI,Kunihiro HAYAKAWA,Makiko YOKOUCHI,Jian YAO,Masanori KITAMURA

39th Annual Meeting of The American Society of Nephrology  2006.11 

Involvement of selective reactive oxygen species upstream of endoplasmic reticulum stress in cadmium-induced apoptosis of renal tubular cells Major achievement

Makiko YOKOUCHI,Nobuhiko HIRAMATSUE,Kunihiro HAYAKAWA,Ayumi KASAI,Yosuke TAKANO,Jian YAO,Masanori KITAMURA

39th Annual Meeting of The American Society of Nephrology  2006.11 

Gap junction propagates and amplifies tubular cell injury induced by nephrotoxic drugs Major achievement

Jian YAO,Ying ZHU,Nobuhiko HIRAMATSUE,Norifumi SAWADA,Masayuki TAKETA,Masanori KITAMURA

39th Annual Meeting of The American Society of Nephrology  2006.11 

Irsogladine maleate potentiates the effects of nitric oxide on activation of cAMP signaling pathway and suppression of mesangial cell mitogenesis Major achievement

Ying ZHU,Jian YAO,Noifumi SAWADA,Nobuhiko HIRAMATSUE,Masayuki TAKETA,Masanori KITAMURA

39th Annual Meeting of The American Society of Nephrology  2006.11 

Cadmium-induced apoptosis of renal tubular cells via endoplasmic reticulum stress: Involvement of selective unfolded protein responses Major achievement

Makiko YOKOUCHI,Nobuhiko HIRAMATSUE,Kunihiro HAYAKAWA,Ayumi KASAI,Yosuke TAKANO,Jian YAO,Masanori KITAMURA

39th Annual Meeting of The American Society of Nephrology  2006.11 

Real-time detection and continuous monitoring of ER stress in vitro and in vivo by ES-TRAP: Evidence for systemic, transient ER stress during endotoxemia Major achievement

Nobuhiko HIRAMATSU,Ayumi KASAI,Kunihiro HAYAKAWA,Jian YAO,Masanori KITAMURA

39th Annual Meeting of The American Society of Nephrology  2006.11 

Secreted protein-based reporter systems for monitoring cellular events: Critical interference by endoplasmic reticulum stress Major achievement

Nobuhiko HIRAMATSUE,Ayumi KASAI,Kunihiro HAYAKAWA,Jian YAO,Masanori KITAMURA

39th Annual Meeting of The American Society of Nephrology  2006.11 

Spontaneous activation of the NF-kB signaling pathway in isolated normal glomeruli Major achievement

Kunihiro HAYAKAWA,Yiman MENG,Nobuhiko HIRAMATSUE,Ayumi KASAI,Jian YAO,Masanori KITAMURA

39th Annual Meeting of The American Society of Nephrology  2006.11 

Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes Major achievement

Yosuke TAKANO,Kotuse YAMAUCHI,Ayumi KASAI,Kunihiro HAYAKAWA,Nobuhiko HIRAMATSUE,Jian YAO,Masanori KITAMURA

39th Annual Meeting of The American Society of Nephrology  2006.11 

細胞間シグナル伝達から見たレニン産生機構 Major achievement

姚　建,北村　正敬

第21回新潟腎シンポジム  2006.9 

Pathophysiological role of intercellular communication in kidney Major achievement

姚　建

2006.8  中国国際中医学研究会

High levels of dioxin-like potential in cigarette smoke in vitro and in vivo evidenced by DRESSA-based biosensing Major achievement

Ayumi KASAI,Nobuhiko HIRAMATSUE,Kunihiro HAYAKAWA,Jian YAO,Masanori KITAMURA

26th International Symposium of Halogenated Persistent Organic Pollutants  2006.8 

腎臓における細胞間コミュニケーションの役割 Major achievement

姚　建

2006.7  解放軍腎研究所

Pathophysiological role of gap junction in kidney Major achievement

姚　建

2006.7  腎臓内科

腎臓における細胞間コミュニケーションの役割 Major achievement

姚　建

第4回中国国際中西医結合腎臓学会  2006.7 

Priming of glomerular cells by activated macrophages induces anergy to proinflammatory stimuli Major achievement

早川　国宏,Yiman MENG,平松　伸彦,河西　あゆみ,姚　建,北村　正敬

20th International Congress of Biochemistry and Molecular Biology  2006.6 

Real-time biosensing of ER stress by ES-TRAP: Evidence for systemic ER stress during endotoxemia Major achievement

平松　伸彦,河西　あゆみ,早川　国宏,姚　建,北村　正敬

20th International Congress of Biochemistry and Molecular Biology  2006.6 

High levels of dioxin-like potential in cigarette smoke in vitro and in vivo evidenced by DRESSA-based biosensing Major achievement

河西　あゆみ,平松　伸彦,早川　国宏,姚　建,北村　正敬

20th International Congress of Biochemistry and Molecular Biology  2006.6 

Profiling of functional phosphodiesterase in mesangial cells using a CRE-SEAP-based reporter system Major achievement

Jian YAO,Ying ZHU,Yiman MENG,Masanori KITAMURA

第49回日本腎臓学会総会  2006.6 

Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes Major achievement

高野　洋介,山内　小津枝,平松　伸彦,河西　あゆみ,早川　国宏,榎本　信幸,姚　建,北村　正敬

第49回日本腎臓学会総会  2006.6 

Involvement of endoplasmic reticulum stress in cadmium-induce apoptosis of tubular cells downstream of oxidative stress Major achievement

横内　万貴子,平松　伸彦,早川　国宏,河西　あゆみ,姚　建,北村　正敬

第49回日本腎臓学会総会  2006.6 

Evidence for endoplasmic reticulum stress during endotoxemia: Real-time detection and continuous monitoring by ES-TRAP-based biosensing Major achievement

平松　伸彦,河西　あゆみ,早川　国宏,姚　建,北村　正敬

第49回日本腎臓学会総会  2006.6 

Critical interference by endoplasmic reticulum stress in secreted protein-based reporter assays Major achievement

平松　伸彦,河西　あゆみ,早川　国宏,姚　建,北村　正敬

第49回日本腎臓学会総会  2006.6 

Spontaneous activation of the NF-?B signaling pathway in isolated normal glomeruli Major achievement

早川　国宏,Yiman MENG,平松　伸彦,河西　あゆみ,姚　建,北村　正敬

第49回日本腎臓学会総会  2006.6 

VRADD: Optimum culture medium for nephrin gene expression in podocytes Major achievement

高野　洋介,山内　小津枝,平松　伸彦,河西　あゆみ,早川　国宏,姚　建,北村　正敬

第49回日本腎臓学会総会  2006.6 

樹状細胞におけるギャップ結合の機能の解析(日本皮膚科学会基礎医学研究費受領者研究発表) Major achievement

松江　弘之,姚　建,松江 啓子,長阪　晶子,椙山　秀昭,青木　類,北村　正敬,島田　眞路

第105回日本皮膚科学会総会  2006.6 

Synergistic effect of PDGF and cAMP-elevating agents on the expression of connexin43 in mesangial cells Major achievement

Jian YAO,Masanori KITAMURA

第4回コネキシン研究会  2005.12 

Profiling of functional phosphodiesterases in mesangial cells Major achievement

Jian YAO,Ying ZHU,Yiman MENG,Masanori KITAMURA

38th Annual Meeting of The American Society of Nephrology  2005.11 

Alkaline phosphatase vs. luciferase as secreted reporter molecules in vivo Major achievement

Nobuhiko HIRAMATSUE,Yiman MENG,Kunihiro HAYAKAWA,Jian YAO,Masanori KITAMURA

38th Annual Meeting of The American Society of Nephrology  2005.11 

Priming of mesangial cells by activated macrophages causes blunted responses to proinflammatory stimuli: A critical role for TNF-α. Major achievement

Kunihiro HAYAKAWA,Yiman MENG,Nobuhiko HIRAMATSUE,Ayumi KASAI,Kotuse YAMAUCHI,Jian YAO,Masanori KITAMURA

38th Annual Meeting of The American Society of Nephrology.  2005.11 

Influence of cAMP on reporter bioassays for dioxin and dioxin-like compounds Major achievement

河西　あゆみ,姚　建,平松　伸彦,早川　国宏,前田　秀一郎,北村　正敬

第8回環境ホルモン学会  2005.9 

Impermissible, high levels of dioxin-like potential of cigarette smoke: Quantitative assessment using DRESSA bioassays (タバコ煙はダイオキシン受容体を高度に活性化する) Major achievement

河西　あゆみ,姚　建,平松　伸彦,早川　国宏,前田　秀一郎,北村　正敬

第8回環境ホルモン学会  2005.9 

Alkaline phosphatase vs. luciferase as secreted reporter molecules in vivo Major achievement

平松　伸彦,河西　あゆみ,Yiman MENG,早川　国宏,姚　建,北村　正敬

第48回日本腎臓学会総会  2005.6 

腎臓病のバイオセンシング Major achievement

北村　正敬,姚　建

第48回日本腎臓学会総会シンポジウム「腎臓病の高度先進医療」  2005.6  第48回日本腎臓学会総会シンポジウム「腎臓病の高度先進医療」

Nitric oxide regulates gap junctional intercellular communication in mesangial cells via cGMP-dependent inhibition of phosphodiesterase 3 Major achievement

Jian YAO,Nobuhiko HIRAMATSUE,Tetsuo MORIOKA,Takashi OITE,Masanori KITAMURA

第48回日本腎臓学会総会  2005.6 

Self-defense of glomerular mesangial cells against macrophage-triggered NF-kB activation Major achievement

早川　国宏,Yiman MENG,平松　伸彦,河西　あゆみ,山内　小津枝,姚　建,北村　正敬

第48回日本腎臓学会総会  2005.6 

樹状細胞間のギヤップ結合(Gap junction)を介した情報伝達は、樹状細胞の活性化に必要である Major achievement

松江　弘之,姚　建,松江 啓子,長阪　晶子,青木　類,北村　正敬,島田　眞路

日本研究皮膚科学会第30回年次学術大会・総会  2005.4 

DRESSA: A bioassay for fast, sensitive and selective detection of dioxin and dioxin-like chemicals using a SEAP reporter system Major achievement

河西　あゆみ,平松　伸彦,Yiman MENG,姚　建,武田　正之,前田　秀一郎,北村　正敬

第27回日本分子生物学会年会  2004.12 

Cooperation of platelet-derived growth factor and cAMP-elevating agents in the induction of connexin43 and mesangial cell differentiation Major achievement

Jian YAO,Masanori KITAMURA,Tetsuo MORIOKA,Takashi OITE

37th annual meeting of american society of nephrology  2004.10 

AP-1-independent sensitization of mesangial cells to oxidative stress-induced apoptosis by proteasome inhibitors Major achievement

Nobuhiko HIRAMATSU,Ayumi KASAI,Jian YAO,Yiman MENG,Masayuki TAKEDA,Shuichiro MAEDA,Masanori KITAMURA

37th Annual Meeting of The American Society of Nephrology  2004.10 

Successive, non-invasive monitoring of glomerulonephritis using a genetically engineered, cell-based biosensor Major achievement

Masanori KITAMURA,Yiman MENG,Ayumi KASAI,Nobuhiko HIRAMATSU,Kunihiro HAYAKAWA,Masayuki TAKEDA,H KAWACHI,F SHIMIZU,Jian YAO

37th Annunal Meeting of The American Society of Nephrology  2004.10 

Continuous, real-time monitoring of mesangial cell - macrophage cross-talk in vitro and ex vivo using secreted alkaline phosphatase Major achievement

Yiman MENG,Ayumi KASAI,Nobuhiko HIRAMATSU,Kunihiro HAYAKAWA,Masayuki TAKEDA,Jian YAO,Masanori KITAMURA

37th Annual Meeting of THE American Society of Nephrology  2004.10 

Nitric oxide enhances mesangial cell connexin43 expression and gap junctional intercellular communication via cGMP-dependent inhibition of phosphodiesterase 3 activity Major achievement

Jian YAO,Nobuhiko HIRAMATSU,Tetsuo MORIOKA,Takashi OITE,Masanori KITAMURA

37th Annual Meeting of the American Society of Nephrology  2004.10 

PDGF induces connexin43 expression and differentiation of mesangial cells in the presence of cAMP Major achievement

Jian YAO,Ying ZHU,Tetsuo MORIOKA,Takashi OITE,Masanori KITAMURA

第47回日本腎臓学会総会  2004.5 

遺伝子工学技術を用いた病勢把握と治療戦略 Major achievement

Masanori KITAMURA,Jian YAO

第47回日本腎臓学会総会  2004.5