Updated on 2024/12/05

写真a

 
Iwano Tomohiko
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine (Advanced Biomedical Research) Senior Assistant Professor
Title
Senior Assistant Professor

Research History

  • University of Yamanashi   Senior Assistant Professor

    2023.5

  • University of Yamanashi   Assistant Professor

    2023.2 - 2023.4

  • University of Yamanashi   Graduate Faculty of Interdisciplinary Research Faculty of Education, Education (Childhood developmental education)   Assistant Professor

    2015.4 - 2023.1

  • Osaka University   Assistant Professor

    2012.10 - 2015.3

  • RIKEN CDB

    2005.4 - 2012.9

  • RIKEN

    2005.4 - 2012.9

  • Kyoto University   Graduate School of Biostudies

    2002.4 - 2005.3

  • Kyoto University   Graduate School of Biostudies

    2000.4 - 2002.3

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Education

  • Kyoto University

    2002.4 - 2005.3

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    Country: Japan

    Course: Doctor course

  • Kyoto University

    2000.4 - 2002.3

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    Country: Japan

    Course: Master course

  • Kyoto University

    1996.4 - 2000.3

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    Country: Japan

Degree

  • 博士(生命科学) ( 2005.3   京都大学 )

Research Areas

  • Life Science / Medical systems  / 質量分析

  • Life Science / Developmental biology  / 神経発生

  • Life Science / Cell biology

Research Interests

  • 包括脳ネットワーク

Research Projects

  • 水頭症モデルマウスのマルチオミクス解析による発症メカニズム解明および代謝正常化による治療への応用

    2022.4 - 2023.3

    日本二分脊椎・水頭症研究振興財団  第28回(2021年度)研究助成 

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    Authorship:Principal investigator  Type of fund::Others

  • 血清1滴の質量分析で膵がんを迅速スクリーニングするハイスループット AI 診断システム の開発

    2022.4 - 2023.3

    AMED  橋渡し研究プログラム・シーズ A 

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    Authorship:Principal investigator  Type of fund::Others

  • 水頭症モデルマウスのマルチオミクス解析による発症メカニズム解明および代謝正常化による治療への応用

    2022.4 - 2023.3

    公益財団法人 日本二分脊椎・水頭症研究振興財団  第28回研究助成 

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    Authorship:Principal investigator 

  • 卵管上皮構築におけるエストロゲン受容体ベータを介した分子機構の解明

    2021.4 - 2025.3

    文部科学省  基盤研究(C)

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    Authorship:Principal investigator  Type of fund::Science research expense

  • 卵管上皮構築におけるエストロゲン受容体ベータを介した分子機構の解明

    Grant number:21K06732  2021.4 - 2024.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    岩野 智彦

  • 卵管上皮細胞の成熟および繊毛運動性に対する天然物由来イソフラボノイド類成分の効能とその機序の解明

    2021.4 - 2022.3

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    Authorship:Principal investigator  Type of fund::Others

  • 卵管上皮細胞の成熟および繊毛運動性に対する天然物由来イソフラボノイド類成分の効能とその機序の解明

    2020.4 - 2022.3

    公益財団法人 小林財団  第8回 研究助成 

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    Authorship:Principal investigator 

  • 卵管上皮細胞の成熟および繊毛運動性に対する天然物由来イソフラボノイド類成分の効能とその機序の解明

    2020.3 - 2021.3

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    Authorship:Principal investigator  Type of fund::Others

  • 多彩なRabエフェクター分子群によるポストゴルジ輸送経路制御機構の包括的解析

    Grant number:19H03181  2019.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    吉村 信一郎, 岩野 智彦

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    ゴルジ体以降のエンドソーム、リソソーム、細胞膜(繊毛を含む)が属する後期輸送経路は複雑なネットワークを形成している。故に後期輸送経路を通過するタンパク質、脂質の輸送の経路及びそれを制御する分子基盤は未だ判然としていない。 複雑な後期輸送経路を支える主要な因子としてRabタンパク質が挙げられる。哺乳動物細胞内の経路にはとりわけ多種のRabが局在しており、Rabタンパク質がその結合分子(エフェクター)とともに重要な機能を担うことが示唆されている。しかしながら現在においてもRabに結合するエフェクターの未同定、不十分な解析などにより、輸送の分子機構の全貌の解明には程遠い。
    本研究では (1) 新規Rabエフェクタータンパク質の探索、解析、(2) それを通じて後期輸送経路の形成、維持の機構、さらにタンパク質輸送における後期輸送経路の役割について未解明な問題の解決を目的とする。
    (1)の新規Rabエフェクタータンパク質の探索、解析に関しては、種々のRabに対してGSTプルダウンによって結合タンパク質を数種同定した。(2)の機能解析については特にRab8結合タンパク質について解析が進んでいる。Rab8結合タンパク質、EHBP1L1については一次繊毛への局在が確認され、さらに本研究で同定されたEHBP1L1結合タンパク質と共に一次繊毛形成に機能することを明らかにした。EHBP1L1とその関連分子に関しては現在学術論文に投稿中である。

  • Development of cerebral ventricular system

    Grant number:17K08511  2017.4 - 2020.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    TAKEDA Sen

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    The aim of this study is to elucidate the morphological basis and molecular mechanisms for maintaining the homeostasis of cerebrospinal fluid (CSF) with special references to its circulation and absorption. By proposing a comprehensive picture of CSF homeostasis, I attempted to understand the pathogenesis of various diseases related to CSF metabolism. In this study, I have clarified the following two directions. 1.Ultrastructural analysis of the arachnoid granulation revealed a lymph-like canaliculi in the arachnoid granulation, which possibly act as conduit or safety valve from subarachnoid space to the venous circulation. 2. CFAP70, a novel structural component of axoneme, plays a pivotal role in circulation of CSF.

  • 卵管上皮ホメオスタシス維持に関わる分子機構の解明

    2017.4 - 2019.3

    若手研究(B)

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    Authorship:Principal investigator  Type of fund::Science research expense

  • The mechanism for the differentiation of ciliated cells in fallopian tube epithelium

    Grant number:17K15543  2017.4 - 2019.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    IWANO Tomohiko, TAKEDA Sen, ZHU Maobi

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    The lumen of the fallopian tube (FT) is lined with columnar epithelium composed of secretory and ciliated cells, both of which are important for reproduction. However, the molecular mechanism regulating the cell fate remains controversial. In this study, we established a primary culture system using porcine fallopian tube epithelial cells (FTECs) to study the differentiation mechanism. I found that estrogen promoted the differentiation of multi-ciliated cells (MCCs) through estrogen receptor β, following the reduction of DLL1, a ligand of Notch. Meanwhile, epidermal growth factor (EGF), a regulator of epithelial homeostasis and differentiation, suppressed ciliogenesis by the activation of Notch signaling. However, the estrogen pathway did not affect the activation of the EGF pathway. Taken together, the differentiation of MMCs in FT depends on the balance of EGF and estrogen signaling, either of which inhibits or stimulates the Notch signaling pathway respectively.

  • 漢方薬由来化合物のヒト卵管上皮細胞の繊毛動態へ与える影響の解析

    2017.4 - 2018.3

    富山大学  和漢医薬学総合研究所共同研究 

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    Authorship:Principal investigator  Type of fund::Joint research

  • 漢方薬由来化合物のヒト卵管上皮細胞の繊毛動態へ与える影響の解析

    2016.5 - 2017.3

    富山大学  和漢医薬学総合研究所共同研究 

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    Authorship:Principal investigator  Type of fund::Joint research

  • 漢方薬由来化合物のヒト卵管上皮細胞の繊毛動態へ与える影響の解析

    2016.4 - 2018.3

    富山大学  富山大学和漢医薬学総合研究所共同研究 

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    Authorship:Principal investigator 

  • Elucidation of functions of genes regulating cell polarity in vivo.

    Grant number:15H04668  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Osaka University  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Harada Akihiro

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    SNAP23 pancreas-specific knockout (KO) mice showed decreased and increased secretion of amylase and insulin, respectively, which was published in JCB. Brain-specific SNAP23 KO mice showed defects in both cerebral and cerebellar cortex, which is being prepared for publication. We showed defects in apical transport in Rab11a KO mice, which was published in Biology Open.
    We identified many genes involved in cell polarity. Two of them, Rab1a and BIG1, an activator of Arf, was knocked out in the mice and the results of BIG1 KO mice was published in Plos One. Other genes, such as Rab1, 11b, syntaxin3 were already knocked out and being analyzed. In addition, we identified novel binding proteins for Rab8 and Rab11. We analyzed their roles in vitro and in vivo and the results were published recently in JCB.

  • Functional analysis of novel polarity-related genes for hippocampal neuronal formation

    Grant number:25860141  2013.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    IWANO Tomohiko, HARADA Akihiro, YOSHIMURA Shin-ichiro

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    To know the functional relationship of novel polarity-related genes for hippocampal neuronal formation, I analyzed the genes which involved in the polarity formation using C. elegans. RNAi analysis. I performed the yeast two-hybrid system to identify the physical relationships of the candidate genes. However, I couldn't identify the significant result of their physical relationships. Therefore, I investigated the gene Rab1, whose knockdown showed significant abnormality in polarized epithelial cells of C.elegans. I analyzed the conditional knockout mice for Rab1a using Nestin-Cre, but can't see any significant abnormality in the behavior and the brain formation. This might come from the redundancy of Rab1b, which is a gene in Rab1 family. Therefore, I must analyze the Rab1a and 1b double knockout mice in the future research.

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Papers

  • Automated sample preparation for electrospray ionization mass spectrometry based on CLOCK- controlled autonomous centrifugal microfluidics Reviewed

    Masahiro Futami, Hiroki Naito, Satoshi Ninomiya, Lee Chuin Chen, Tomohiko Iwano, Kentaro Yoshimura Yoshiaki Ukita

    Biomed Microdevices   26 ( 2 )   22   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10544-024-00703-4

  • New Diagnostic Modality Combining Mass Spectrometry and Machine Learning for the Discrimination of Malignant Intraductal Papillary Mucinous Neoplasms. Reviewed

    Kiritani S, Iwano T, Yoshimura K, Saito R, Nakayama T, Yamamoto D, Hakoda H, Watanabe G, Akamatsu N, Arita J, Kaneko J, Takeda S, Ichikawa D, Hasegawa K.

    ANNALS OF SURGICAL ONCOLOGY   2023.5( ISSN:1068-9265  eISSN:1534-4681 )

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Background

    An intraductal papillary mucinous neoplasm (IPMN) is a pancreatic tumor with malignant potential. Although we anticipate a sensitive method to diagnose the malignant conversion of IPMN, an effective strategy has not yet been established. The combination of probe electrospray ionization-mass spectrometry (PESI-MS) and machine learning provides a promising solution for this purpose.

    Methods

    We prospectively analyzed 42 serum samples obtained from IPMN patients who underwent pancreatic resection between 2020 and 2021. Based on the postoperative pathological diagnosis, patients were classified into two groups: IPMN-low grade dysplasia (n = 17) and advanced-IPMN (n = 25). Serum samples were analyzed by PESI-MS, and the obtained mass spectral data were converted into continuous variables. These variables were used to discriminate advanced-IPMN from IPMN-low grade dysplasia by partial least square regression or support vector machine analysis. The areas under receiver operating characteristics curves were obtained to visualize the difference between the two groups.

    Results

    Partial least square regression successfully discriminated the two disease classes. From another standpoint, we selected 130 parameters from the entire dataset by PESI-MS, which were fed into the support vector machine. The diagnostic accuracy was 88.1%, and the area under the receiver operating characteristics curve was 0.924 by this method. Approximately 10 min were required to perform each method.

    Conclusion

    PESI-MS combined with machine learning is an easy-to-use tool with the advantage of rapid on-site analysis. Here, we show the great potential of our system to diagnose the malignant conversion of IPMN, which would be a promising diagnostic tool in clinical settings.

    DOI: 10.1245/s10434-022-13012-y

    PubMed

    Other Link: https://link.springer.com/article/10.1245/s10434-022-13012-y/fulltext.html

  • Probe electrospray ionization mass spectrometry-based rapid diagnosis of liver tumors Reviewed

    Hakoda H, Kiritani S, Kokudo T, Yoshimura K, Iwano T, Tanimoto M, Ishizawa T, Arita J, Akamatsu N, Kaneko J, Takeda S, Hasegawa K.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   37 ( 11 )   2182 - 2188   2022.11( ISSN:0815-9319 )

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.15976.

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  • High-performance Collective Biomarker from Liquid Biopsy for Diagnosis of Pancreatic Cancer Based on Mass Spectrometry and Machine Learning Reviewed Major achievement

    Tomohiko Iwano, Kentaro Yoshimura, Genki Watanabe, Ryo Saito, Sho Kiritani, Hiromichi Kawaida, Takeshi Moriguchi, Tasuku Murata, Koretsugu Ogata, Daisuke Ichikawa, Junichi Arita, Kiyoshi Hasegawa, Sen Takeda

    Journal of Cancer   12 ( 24 )   7477 - 7487   2021.11( ISSN:1837-9664 )

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:IVYSPRING  

    Background: Most pancreatic cancers are found at progressive stages when they cannot be surgically removed. Therefore, a highly accurate early detection method is urgently needed. Methods: This study analyzed serum from Japanese patients who suffered from pancreatic ductal adenocarcinoma (PDAC) and aimed to establish a PDAC-diagnostic system with metabolites in serum. Two groups of metabolites, primary metabolites (PM) and phospholipids (PL), were analyzed using liquid chromatography/electrospray ionization mass spectrometry. A support vector machine was employed to establish a machine learning-based diagnostic algorithm. Results: Integrating PM and PL databases improved cancer diagnostic accuracy and the area under the receiver operating characteristic curve. It was more effective than the algorithm based on either PM or PL database, or single metabolites as a biomarker. Subsequently, 36 statistically significant metabolites were fed into the algorithm as a collective biomarker, which improved results by accomplishing 97.4% and was further validated by additional serum. Interestingly, specific clusters of metabolites from patients with preoperative neoadjuvant chemotherapy (NAC) showed different patterns from those without NAC and were somewhat comparable to those of the control. Conclusion: We propose an efficient screening system for PDAC with high accuracy by liquid biopsy and potential biomarkers useful for assessing NAC performance.

    DOI: 10.7150/jca.63244

    PubMed

  • New strategy for evaluating pancreatic tissue specimens from endoscopic ultrasound-guided fine needle aspiration and surgery Reviewed

    Seiichiro Fukuhara, Eisuke Iwasaki, Tomohiko Iwano, Yujiro Machida, Hiroki Tamagawa, Shintaro Kawasaki, Takashi Seino, Takahiro Yokose, Yutaka Endo, Kentaro Yoshimura, Kazuhiro Kashiwagi, Minoru Kitago, Haruhiko Ogata, Sen Takeda and Takanori Kanai

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   5 ( 8 )   953 - 958   2021.7( ISSN:0815-9319 )

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    Background and Aim: Preoperative histological evaluation of pancreatic neoplasms is important for guiding the resection strategy and preventing postoperative adverse events. However, conventional endoscopic methods have technical limitations that reduce the accuracy of the histopathological examination. Probe electrospray ionization mass spectrometry (PESI-MS) may be a useful technique for rapidly evaluating small specimens. Methods: This single-center prospective study included patients with pancreatic neoplasms between October 2018 and December 2019. Pancreatic ductal adenocarcinoma (PDAC) specimens were obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and non-neoplastic tissue was obtained via surgery. Specimens were subjected to PESI-MS and the mass spectra were analyzed using partial least squares regression-discriminant analysis. Results: The study included 40 patients with 20 nonneoplastic specimens and 19 PDAC specimens (1 case of neuroendocrine carcinoma was omitted). All nonneoplastic specimens were sufficient for PESI-MS analysis, although only 7 of 19 PDAC specimens were sufficient for PESI-MS analysis because of poor sample quality or insufficient quantity (<1 mg). Among the 27 analyzed cases, the mass spectra clearly differentiated between the PDAC and nonneoplastic specimens. Conclusions: This study revealed that PESI-MS could differentiate between PDAC and nonneoplastic specimens, even in cases where EUS-FNA produced very small specimens.

    DOI: 10.1002/jgh3.12617

    PubMed

  • Diagnostic significance of plasma lipid markers and machine learning‐based algorithm for gastric cancer Reviewed

    Ryo Saito, Kentaro Yoshimura, Katsutoshi Shoda, Shinji Furuya, Hidenori Akaike, Yoshihiko Kawaguchi, Tasuku Murata, Koretsugu Ogata, Tomohiko Iwano, Sen Takeda, Daisuke Ichikawa

    Oncology Letters   21 ( 5 )   405 - 405   2021.5( ISSN:1792-1074 )

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    Biomarkers may be of value for the early detection of gastric cancer (GC) and the preoperative identification of tumor characteristics to guide treatment strategies. The present study analyzed the expression levels of phospholipids in plasma from patients with GC using liquid chromatography/electrospray ionization-mass spectrometry (LC/ESI-MS) to detect reliable biomarkers for GC. Furthermore, combining the results with a machine learning strategy, the present study attempted to establish a diagnostic system for GC. A total of 20 plasma samples from preoperative patients with GC and 16 plasma samples from tumor-free patients (controls) were selected from our biobank named 'SHINGEN (Yamanashi Biobank of Gastroenterological Cancers)', which includes a total of 1,592 plasma samples, and were analyzed by LC/ESI-MS. The obtained data were discriminated using a machine learning-based diagnostic algorithm, whose discriminant ability was confirmed through leave-one-out cross-validation. Using LC/ESI-MS, the levels of 236 lipid molecules were determined. Biomarker analysis revealed that a few lipids that were downregulated in the GC group could discriminate between the GC and control groups. Whole lipid composition analysis using partial least squares regression revealed good discrimination ability between the GC and control groups. Integrative analysis of all molecules using the aforementioned machine learning method exhibited a diagnostic accuracy of 94.4% (specificity, 93.8%; sensitivity, 95.0%). In conclusion, the outcomes of the present study suggested the potential future application of the aforementioned system in clinical settings. By accumulating more reliable data, the present system will be able to detect early-stage cancer and will be capable of predicting the efficacy of each therapeutic strategy.

    DOI: 10.3892/ol.2021.12666

    PubMed

  • Natural Herbal Estrogen-Mimetics (Phytoestrogens) Promote the Differentiation of Fallopian Tube Epithelium into Multi-Ciliated Cells via Estrogen Receptor Beta Reviewed Major achievement

    Maobi Zhu, Sen Takeda and Tomohiko Iwano

    MOLECULES   26 ( 3 )   722   2021.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI  

    Phytoestrogens are herbal polyphenolic compounds that exert various estrogen-like effects in animals and can be taken in easily from a foodstuff in daily life. The fallopian tube lumen, where transportation of the oocyte occurs, is lined with secretory cells and multi-ciliated epithelial cells. Recently, we showed that estrogen induces multi-ciliogenesis in the porcine fallopian tube epithelial cells (FTECs) through the activation of the estrogen receptor beta (ERβ) pathway and simultaneous inhibition of the Notch pathway. Thus, ingested phytoestrogens may induce FTEC ciliogenesis and thereby affect the fecundity. To address this issue, we added isoflavones (genistein, daidzein, or glycitin) and coumestan (coumestrol) to primary culture FTECs under air-liquid interface conditions and assessed the effects of each compound. All phytoestrogens except glycitin induced multi-ciliated cell differentiation, which followed Notch signal downregulation. On the contrary, the differentiation of secretory cells decreased slightly. Furthermore, genistein and daidzein had a slight effect on the proportion of proliferating cells exhibited by Ki67 expression. Ciliated-cell differentiation is inhibited by the ERβ antagonist, PHTPP. Thus, this study suggests that phytoestrogens can improve the fallopian tube epithelial sheet homeostasis by facilitating the genesis of multi-ciliated cells and this effect depends on the ERβ-mediated pathway.

    DOI: 10.3390/molecules26030722

    PubMed

  • SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity. Reviewed

    Masataka Kunii, Yuria Noguchi, Shin-Ichiro Yoshimura, Satoshi Kanda, Tomohiko Iwano, Erda Avriyanti, Nur Atik, Takashi Sato, Ken Sato, Masaharu Ogawa, Akihiro Harada

    JOURNAL OF CELL BIOLOGY   220 ( 1 )   2021.1( ISSN:0021-9525 )

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  • Miniaturized String Sampling Probe and Electrospray Extraction/Ionization within the Ion Inlet Tube for Mass Spectrometric Endoscopy. Reviewed

    Lee Chuin Chen, Tomohiko Iwano, Satoshi Ninomiya, Takayuki Koike, Yoshihisa Tanaka, Kentaro Yoshimura

    JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY   2020.12( ISSN:1044-0305 )

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  • Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro-Stem Cell of Fallopian Epithelium. Reviewed

    Maobi Zhu,Tomohiko Iwano,Sen Takeda

    Biomolecules   10 ( 9 )   2020.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Diagnosis of breast cancer based on lipid profiling by probe electrospray ionization mass spectrometry Reviewed Major achievement

    Tomohiko Iwano, Kentaro Yoshimura, Shingo Inoue, Toru Odate, K Ogata, S Funatsu, H Tanihata, Tetsuo Kondo, Daisuke Ichikawa, Sen Takeda

    BRITISH JOURNAL OF SURGERY   107 ( 6 )   632 - 635   2020.4( ISSN:0007-1323 )

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Estrogen and EGFR Pathways Regulate Notch Signaling in Opposing Directions for Multi-ciliogenesis in the Fallopian Tube Reviewed Major achievement

    Maobi Zhu, Tomohiko Iwano, Sen Takeda

    Cells   8 ( 8 )   933   2019.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    The lumen of the fallopian tube (FT) is lined with columnar epithelium composed of secretory and ciliated cells, both of which are important for reproduction. However, the molecular mechanism regulating cell fate remains controversial. In this study, we established a primary culture system using porcine fallopian tube epithelial cells (FTECs) to study the differentiation mechanism. We found that estrogen promoted the differentiation of multi-ciliated cells (MCCs) through estrogen receptor β, following the reduction of DLL1, a ligand of Notch. Meanwhile, epidermal growth factor (EGF), a regulator of epithelial homeostasis and differentiation, suppressed ciliogenesis by the activation of Notch signaling. However, the estrogen pathway did not affect the activation of the EGF pathway. Taken together, the differentiation of MMCs in FT depends on the balance of EGF and estrogen signaling, either of which inhibits or stimulates the Notch signaling pathway respectively.

    DOI: 10.3390/cells8080933

    PubMed

  • BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain Reviewed

    Jia-Jie Teoh, Tomohiko Iwano, Masataka Kunii, Nur Atik, Erda Avriyanti, Shin-ichiro Yoshimura, Kenta Moriwaki, Akihiro Harada

    PLoS One   e0175888   2017.4( ISSN:1932-6203 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells Reviewed

    Atsuhiro Nakajo, Shin-ichiro Yoshimura, Hiroko Togawa, Masataka Kunii, Tomohiko Iwano, Ayaka Izumi, Yuria Noguchi, Ayako Watanabe, Ayako Goto, Toshiro Sato, Akihiro Harada

    JOURNAL OF CELL BIOLOGY   212   297-306   2016.2( ISSN:0021-9525 )

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  • Prox1 regulates the subtype-specific development of caudal ganglionic eminence-derived GABAergic cortical interneurons Reviewed

    Goichi Miyoshi, Allison Young, Timothy Petros, Theofanis Karayannis, Melissa McKenzie Chang, Alfonso Lavado, Tomohiko Iwano, Miho Nakajima, Hiroki Taniguchi, Z Josh Huang, Nathaniel Heintz, Guillermo Oliver, Fumio Matsuzaki, Robert P Machold, Gord Fishell

    JOURNAL OF NEUROSCIENCE   35   12869   2015.9( ISSN:0270-6474 )

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  • Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis Reviewed Major achievement

    Takashi Sato, Tomohiko Iwano, Masataka Kunii, Shinji Matsuda, Rumiko Mizuguchi, Yongwook Jung, Haruo Hagiwara, Yoshihiro Yoshihara, Michisuke Yuzaki, Reiko Harada, Akihiro Harada

    Journal of Cell Science, (2014IF=5.432)   127 ( 2 )   422 - 431   2014.1( ISSN:0021-9533 )

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus Reviewed

    Tomohiko Iwano, Aki Masuda, Hiroshi Kiyonari, Hideki Enomoto, Fumio Matsuzaki

    Development (IF2014=6.462)   139 ( 16 )   3051 - 3062   2012.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

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Books and Other Publications

  • 実践 卵管学

    柴原浩章( Role: ContributorIII. 卵管研究の最前線[2]4章)

    中外医学社  2020.12   ISBN:978-4-498-16012-5

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    Total pages:14   Responsible for pages:63-76   Language:Japanese   Book type:Textbook, survey, introduction

Presentations

  • Estrogen receptor beta promotes differentiation of multi-ciliated epithelial cells in the fallopian tube

    2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Poster presentation  

  • Natural Herbal Estrogen-Mimetics (Phytoestrogens) Promote the Differentiation of Fallopian Tube Epithelium Into Multi-Ciliated Cells via Estrogen Receptor Beta

    2021.3 

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    Event date: 2021.3

    Language:English   Presentation type:Poster presentation  

  • Diagnosis of breast cancer based on lipid profiling by probe electrospray ionization mass spectrometry

    Tomohiko Iwano

    2020.5 

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    Event date: 2020.5

    Language:Japanese   Presentation type:Poster presentation  

  • 一次繊毛長制御に関わるRab8結合タンパク質の機能解析

    第124回日本解剖学会総会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Poster presentation  

  • 漢方薬由来化合物のヒト卵管上皮細胞の繊毛動態へ与える影響の解析

    岩野智彦

    平成29年度共同研究報告セミナー  2018.3 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:富山大学和漢医薬学総合研究所  

  • 一次繊毛長制御に関わるRab8結合タンパク質の機能解析

    第122回日本解剖学会総会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:長崎大学  

  • 漢方薬由来化合物のヒト卵管上皮細胞の繊毛動態へ与える影響の解析

    岩野智彦

    平成28年度共同研究報告セミナー  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:富山大学和漢医薬学総合研究所  

  • Opposite mechanisms to control cilia length depending on the interacting proteins of Rab8

    The 28th CDB meeting: Cilia and centrosomes  2016.11  RIKEN CDB, cilia club

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Venue:Kobe  

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Industrial Property Rights

  • 解析方法及び解析システム Major achievement

    岩野智彦、吉村健太郎

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    Applicant:国立大学法人山梨大学

    Application no:特願2023-062125  Date applied:2023.4

Teaching Experience (On-campus)

  • 解剖学A(組織学)

    2020Year  Type of subject:Professional education (undergraduate)

  • 解剖学B(神経科学)

    2020Year  Type of subject:Professional education (undergraduate)

  • Life Science of the Human Body

    2020Year

  • 解剖学B(肉眼解剖)

    2019Year  Type of subject:Professional education (undergraduate)

  • 解剖学B(神経科学)

    2019Year  Type of subject:Professional education (undergraduate)

  • 解剖学B(肉眼解剖)

    2018Year  Type of subject:Professional education (undergraduate)

  • 解剖学A(組織学)

    2018Year  Type of subject:Professional education (undergraduate)

  • 解剖学B(神経科学)

    2018Year  Type of subject:Professional education (undergraduate)

  • 統合講義

    2017Year  Type of subject:Professional education (undergraduate)

  • 解剖学B(肉眼解剖学)

    2017Year  Type of subject:Professional education (undergraduate)

  • 解剖学A(組織学)

    2017Year  Type of subject:Professional education (undergraduate)

  • 神経解剖学 Major achievement

    2017Year  Type of subject:Professional education (undergraduate)

  • 解剖学B(肉眼解剖学)

    2016Year  Type of subject:Professional education (undergraduate)

  • 解剖学A(組織学)

    2016Year  Type of subject:Professional education (undergraduate)

  • 神経解剖学 Major achievement

    2016Year  Type of subject:Professional education (undergraduate)

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Teaching Experience

  • histology

    2017.4
    Institution:University of Yamanashi

  • anatomy

    2015.4
    Institution:University of Yamanashi

  • histology

    2012.9
    -
    2015.3
    Institution:Osaka University

Guidance results

  • 2020

    Type:Undergraduate (Major A course)graduation thesis guidance  Period:12months

    Number of people receiving guidance :1people 

    Graduation / pass / number of people awarded degrees :1people 

    Number of teachers:2people

  • 2019

    Type:Ph.D. dissertations guidance

    Number of people receiving guidance :1people 

  • 2019

    Type:Achievement of student guidance (Undergraduate)

    Number of people receiving guidance :1people 

  • 2017

    Type:Ph.D. dissertations guidance

    Number of people receiving guidance :1people  (Overseas students):1people

    Number of teachers:2people

  • 2016

    Type:Ph.D. dissertations guidance

    Number of people receiving guidance :1people  (Overseas students):1people

    Number of teachers:2people

  • 2016

    Type:Achievement of student guidance (Undergraduate)  Period:12months  Year guidance time:50hours

    Number of people receiving guidance :1people 

    Number of teachers:1people

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Professional Memberships

  • クロマトグラフィー学会

    2024.1

  • 日本医用マススペクトル学会

    2023.4

  • 日本神経科学会

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

  • THE JAPANESE ASSOCIATION OF ANATOMISTS