Diagnostic Accuracy of Ambient Mass Spectrometry with Blood Plasma in a Murine Glioma Model Using Machine Learning Reviewed

Hirofumi Kazama, Mitsuto Hanihara, Kentaro Yoshimura, Tomohiko Iwano, Ryu Saito, Masakazu Ogiwara, Tomoyuki Kawataki, Hideyuki Yoshioka, Hiroyuki Kinouchi

World Neurosurgery   194   1 - 7   2025.2( ISSN：1878-8750 )

Noncanonical TCA cycle fosters canonical TCA cycle and mitochondrial integrity in acute myeloid leukemia Reviewed

Atsushi Watanabe, Chartsiam Tipgomut, Haruhito Totani, Kentaro Yoshimura, Tomohiko Iwano, Hamed Bashiri, Lee Hui Chua, Chong Yang, Toshio Suda

CANCER SCIENCE   116 ( 1 )   152 - 163   2024.10( ISSN：1347-9032 )

Ambient Mass Spectrometry and Machine Learning-Based Diagnosis System for Acute Coronary Syndrome Reviewed

Que N. N. Tran, Takeshi Moriguchi, Masateru Ueno, Tomohiko Iwano, Kentaro Yoshimura

JOURNAL OF MASS SPECTROMETRY   13 ( 1 )   1 - 7   2024.7( ISSN：1076-5174 )

Automated sample preparation for electrospray ionization mass spectrometry based on CLOCK- controlled autonomous centrifugal microfluidics Reviewed

Masahiro Futami, Hiroki Naito, Satoshi Ninomiya, Lee Chuin Chen, Tomohiko Iwano, Kentaro Yoshimura, Yoshiaki Ukita

Biomedical Microdevices   in press   2024.3

New diagnostic modality combining mass spectrometry and machine learning for the discrimination of malignant intraductal papillary mucinous neoplasms Reviewed

Sho Kiritani, Tomohiko Iwano, Kentaro Yoshimura, Ryo Saito, Daisuke Yamamoto, Hiroyuki Hakoda, Genki Watanabe, Nobuhisa Akamatsu, Junichi Arita, Junichi Kaneko, Sén Takeda, Daisuke Ichikawa, Kiyoshi Hasegawa

ANNALS OF SURGICAL ONCOLOGY   in press   2023.1( ISSN：1068-9265 )

Probe electrospray ionization mass spectrometry-based rapid diagnosis of liver tumors Reviewed

Hiroyuki Hakoda, Sho Kiritani, Takashi Kokudo, Kentaro Yoshimura, Tomohiko Iwano, Meguri Tanimoto, Takeaki Ishizawa, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Sen Takeda, Kiyoshi Hasegawa

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   37 ( 11 )   2182 - 2188   2022.11( ISSN：0815-9319  eISSN：1440-1746 )

Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL Reviewed

Koshi Akahane, Shunsuke Kimura, Kunio Miyake, Atsushi Watanabe, Keiko Kagami, Kentaro Yoshimura, Tamao Shinohara, Daisuke Harama, Shin Kasai, Kumiko Goi, Tomoko Kawai, Kenichiro Hata, Nobutaka Kiyokawa, Katsuyoshi Koh, Toshihiko Imamura, Keizo Horibe, A. Thomas Look, Masayoshi Minegishi, Kanji Sugita, Junko Takita, and Takeshi Inukai

Blood Advances   6 ( 1 )   212 - 224   2021.12( ISSN：2473-9529 )

High-performance Collective Biomarker From Liquid Biopsy For Diagnosis Of Pancreatic Cancer Based On Mass Spectrometry And Machine Learning Reviewed

T Iwano, K Yoshimura, G Watanabe, R Saito, S Kiritani, H Kawaida, T Moriguchi, T Murata, K Ogata, D Ichikawa, J Arita, K Hasegawa, S Takeda

Journal of Cancer   12 ( 24 )   7477 - 7487   2021.11( ISSN：1837-9664 )

New strategy for evaluating pancreatic tissue specimens from endoscopic ultrasound-guided fine needle aspiration and surgery Reviewed

Seiichiro Fukuhara, Eisuke Iwasaki, Tomohiko Iwano, Yujiro Machida, Hiroki Tamagawa, Shintaro Kawasaki, Takashi Seino, Takahiro Yokose, Yutaka Endo, Kentaro Yoshimura, Kazuhiro Kashiwagi, Minoru Kitago, Haruhiko Ogata, Sen Takeda, Takanori Kanai

JGH Open   5 ( 8 )   953 - 958   2021.8

Diagnostic significance of plasma lipid markers and machine learning-based algorithm for gastric cancer Reviewed

RYO SAITO, KENTARO YOSHIMURA, KATSUTOSHI SHODA, SHINJI FURUYA, HIDENORI AKAIKE, YOSHIHIKO KAWAGUCHI, TASUKU MURATA, KORETSUGU OGATA, TOMOHIKO IWANO, SEN TAKEDA, DAISUKE ICHIKAWA

Oncology Letters   21 ( 5 )   1 - 8   2021.3( ISSN：1792-1074  eISSN：1792-1082 )

Prediction of Pathological and Radiological Nature of Glioma by Mass Spectrometry Combined With Machine Learning Reviewed

Keiko Suzuki, Kentaro Yoshimura, Tomoyuki Kawataki, Mitsuto Hanihara, Sen Takeda, Hiroyuki Kinouchi

Neurosurgery Open   2 ( 1 )   1 - 8   2021.3(  eISSN：2633-0873 )

A new rapid diagnostic system with ambient mass spectrometry and machine learning for colorectal liver metastasis Reviewed

Sho Kiritani, Kentaro Yoshimura, Junichi Arita, Takashi Kokudo, Hiroyuki Hakoda, Meguri Tanimoto, Takeaki Ishizawa, Nobuhisa Akamatsu, Junichi Kaneko, Sen Takeda, Kiyoshi Hasegawa

BMC CANCER   21 ( 1 )   1 - 9   2021.3( ISSN：1471-2407  eISSN：1471-2407 )

Miniaturized String Sampling Probe and Electrospray Extraction/Ionization within the Ion Inlet Tube for Mass Spectrometric Endoscopy Reviewed

Lee Chuin Chen, Tomohiko Iwano, Satoshi Ninomiya, Takayuki Koike, Yoshihisa Tanaka, Kentaro Yoshimura

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY   21 ( 2 )   606 - 610   2021.2( ISSN：1044-0305  eISSN：1879-1123 )

Probe Electrospray Ionization (PESI) and Its Modified Versions: Dipping PESI (dPESI), Sheath-Flow PESI (sfPESI) and Adjustable sfPESI (ad-sfPESI) Reviewed

Kenzo Hiraoka, Osamu Ariyada, Dilshadbek T Usmanov, Lee C Chen, Satoshi Ninomiya, Kentaro Yoshimura, Sen Takeda, Zhang Yu, Mridul K Mandal, Hiroshi Wada, Stephanie Rankin-Turner, Hiroshi Nonami

JOURNAL OF MASS SPECTROMETRY   9 ( 1 )   1 - 21   2020.12( ISSN：1076-5174  eISSN：2186-5116 )

Rapid automated diagnosis of primary hepatic tumor by mass spectrometry and artificial intelligence Reviewed

Silvia Giordano, Sen Takeda, Matteo Donadon, Hidekazu Saiki, Laura Brunelli, Roberta Pastorelli, Matteo Cimino, Cristiana Soldani, Barbara Franceschini, Luca Di Tommaso, Ana Lleo, Kentaro Yoshimura, Hiroki Nakajima, Guido Torzilli, Enrico Davoli

LIVER INTERNATIONAL   40 ( 12 )   3117 - 3124   2020.12( ISSN：1478-3223  eISSN：1478-3231 )

Breast cancer diagnosis based on lipid profiling by probe electrospray ionization mass spectrometry Reviewed

T Iwano, K Yoshimura, S Inoue, T Odate , K Ogata, S Funatsu, H Tanihata, T Kondo, D Ichikawa, S Takeda

BRITISH JOURNAL OF SURGERY   107 ( 6 )   632 - 635   2020.5( ISSN：0007-1323 )

Sample Preparation for Probe Electrospray Ionization Mass Spectrometry Reviewed

Jove-Journal of Visualized Experiments   ( 156 )   2020.2( ISSN：1940-087X )

Lipidome-based rapid diagnostic system with machine learning for detection of tumor areas with activated TGF-β signaling in head and neck cancer Reviewed

BRITISH JOURNAL OF CANCER   2020.2( ISSN：0007-0920 )

Using Probe Electrospray Ionization Mass Spectrometry and Machine Learning for Detecting Pancreatic Cancer with High Performance Reviewed

American Journal of Translational Research   12 ( 1 )   171 - 179   2020.1( ISSN：1943-8141 )

Real-time analysis of living animals and rapid screening of human fluid samples using remote sampling electrospray ionization mass spectrometry Reviewed

Kentaro Yoshimura, Yuki Yamada, Satoshi Ninomiya, Wen Yuan Chung, Yu-Ting Chang, Ashley Robert Dennison, Kenzo Hiraoka, Sen Takeda, Lee Chuin Chen

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS   172   372 - 378   2019.8( ISSN：0731-7085 )

Ambient mass spectrometry-based detection system for tumor cells in human blood Reviewed

Translational Cancer Research   7 ( 3 )   758 - 764   2018.6( ISSN：2218-676X )

Detection of potential new biomarkers of atherosclerosis by probe electrospray ionization mass spectrometry Reviewed

Hisashi Johno, Kentaro Yoshimura, Yuki Mori, Tokuhide Kimura, Manabu Niimi, Masaki Yamada, Tetsuo Tanigawa, Jianglin Fan, Sen Takeda

Metabolomics   14 ( 38 )   1 - 11   2018.2( ISSN：1573-3882 )

Construction of mass spectra database and diagnosis algorithm for head and neck squamous cell carcinoma Reviewed

Kei Ashizawa, Kentaro Yoshimura, Hisashi Johno, Tomohiro Inou, Ryohei Katoh, Satoshi Funayama, Kaname Sakamoto, Sen Takeda, Keisuke Masuyama, Tomokazu Matsuoka, Hiroki Ishii

ORAL ONCOLOGY   75   111 - 119   2017.12( ISSN：1368-8375  eISSN：1879-0593 )

Towards Practical Endscopic Mass Spectrometry Reviewed

Lee Chuin Chen, Kentaro Yoshimura, Satoshi Ninomiya, Sen Takeda, Kenzo Hiraoka,

JOURNAL OF MASS SPECTROMETRY   6 ( S0070 )   1 - 8   2017.8( ISSN：1076-5174 )

In-vivo Endoscopic Mass Spectrometry using a Moving String Sampling Probe Reviewed

Lee Chuin Chen, Tsubasa Naito, Satoru Tsutsui, Yuki Yamada, Satoshi Ninomiya, Kentaro Yoshimura, Sen Takeda, Kenzo Hiraoka

ANALYST   142 ( 15 )   2735 - 2740   2017.7( ISSN：0003-2654  eISSN：1364-5528 )

Hepatitis B virus prevents excessive viral production via reduction of cell-death inducing DFF45-like effectors Reviewed

Jun Yasumoto, Hirotake Kasai, Kentaro Yoshimura, Teruhime Otoguro, Koichi Watashi, Takaji Wakita, Atsuya Yamashita, Tomohisa Tanaka, Sen Takeda, Kohji Moriishi

JOURNAL OF GENERAL VIROLOGY   98 ( 7 )   1762 - 1773   2017.7( ISSN：0022-1317  eISSN：1465-2099 )

Desorption in Mass Spectrometry Reviewed

Dilshadbek Tursunbayevich Usmanov, Satoshi Ninomiya, Lee Chuin Chen, Subhrakanti Saha, Mridul Kanti Mandal, Yuji Sakai, Rio Takaishi, Ahsan Habib, Kenzo Hiraoka, Kentaro Yoshimura, Sen Takeda, Hiroshi Wada, Hiroshi Nonami

JOURNAL OF MASS SPECTROMETRY   6 ( S0059 )   1 - 16   2017.2( ISSN：1076-5174 )

Secondary Ion Mass Spectrometry Analysis of Renal Cell Carcinoma with Electrospray Droplet Ion Beams Reviewed

Satoshi Ninomiya ,Kentaro Yoshimura ,Lee Chuin Chen ,Sen Takeda ,Kenzo Hiraoka

JOURNAL OF MASS SPECTROMETRY   6 ( A0053 )   1 - 6   2017.1( ISSN：1076-5174 )

Modulation of primary cilia length by melanin-concentrating hormone receptor 1 Reviewed

Akie Hamamoto,Shogo Yamato,Yohei Katoh,Kazuhisa Nakayama,Kentaro Yoshimura(他3名)

CELLULAR SIGNALLING   28 ( 6 )   572 - 584   2016.6( ISSN：0898-6568  eISSN：1873-3913 )

Involvement of FKBP6 in hepatitis C virus replication Reviewed

Hirotake Kasai,Kunihiro Kawakami,Hiromasa Yokoe,Kentaro Yoshimura,Masanori Matsuda,その他15名

Scientific reports   16 ( 5 )   16699 - 16699   2015.11( ISSN：20452322 )

Untreated and dried sample analysis by solid probe assisted nanoelectrospray ionization mass spectrometry Reviewed

Mridul Kanti Mandal,Subhrakanti Saha,Zhan Yu,Kentaro Yoshimura,Sen Takeda,Kenzo Hiraoka

Analytical Methods   7 ( 6 )   2630 - 2635   2015.2( ISSN：17599679  eISSN：1759-9679 )

Development of Non-proximate Probe Electrospray Ionization for Real-Time Analysis of Living Animal Reviewed

Kentaro Yoshimura,Lee Chuin Chen,Hisashi Johno,Mayutaka Nakajima,Kenzo Hiraoka,Sen Takeda

Mass Spectrometry   3 ( SP3 )   1 - 7   2014.12( ISSN：2187137X )

Biomolecular analysis and biological tissue diagnostics by electrospray ionization with a metal wire inserted gel-loading tip Reviewed

Mandal MK,Yoshimura K,Saha S,Yu Z,Takeda S,Hiraoka K.

Analytical Chemistry   86 ( 2 )   987 - 992   2014.1( ISSN：00032700  eISSN：1520-6882 )

Direct Electrospray Ionization Mass Spectrometric Profiling of Real-World Samples via a Solid Sampling Probe Reviewed

Zhan Yu,Lee Chuin Chen,Mridul Kanti Mandal,Kentaro Yoshimura,Sen Takeda,Kenzo Hiraoka

Journal of The American Society for Mass Spectrometry   24 ( 10 )   1612 - 1615   2013.10( ISSN：10440305 )

Real time diagnosis of chemically-induced hepatocellular carcinoma using a novel mass spectrometry-based technique Reviewed

Kentaro Yoshimura,Mridul Kanti Mandal,Michio Hara,Hideki Fujii,Lee Chuin Chen,Kunio Tanabe,Kenzo Hiraoka,Sen Takeda

Analytical Biochemistry   441 ( 1 )   32 - 37   2013.10( ISSN：00032697 )

Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1 Reviewed

Asami Nagata,Akie Hamamoto,Manabu Horikawa,Kentarou Yoshimura,その他2名

General and Comparative Endocrinology   188 ( 188 )   159 - 165   2013.7( ISSN：00166480 )

Biomolecular analysis and cancer diagnostics by negative mode probe electrospray ionization Reviewed

Mandal MK,Saha S,Yoshimura K,Shida Y,Takeda S,その他2名

Analyst   138 ( 6 )   1682 - 1688   2013.3( ISSN：00032654 )

Application of Probe Electrospray Ionization Mass Spectrometry (PESI-MS) to Clinical Diagnosis: Solvent Effect on Lipid Analysis Reviewed

Mandal MK,Yoshimura K,Chen LC,Yu Z,その他5名

Journal of The American Society for Mass Spectrometry   23 ( 11 )   2043 - 2047   2012.11( ISSN：10440305 )

Solid Probe Assisted Nanoelectrospray Ionization Mass Spectrometry for Biological Tissue Diagnostics Reviewed

Mridul Kanti Mandal,Kentaro Yoshimura,Subhrakanti Saha,Satoshi Ninomiya,その他7

Analyst   137 ( 20 )   4658 - 4661   2012.10( ISSN：00032654 )

Analysis of Renal Cell Carcinoma as a First Step for Developing Mass Spectrometry–Based Diagnostics Reviewed

Kentaro Yoshimura,Lee Chuin Chen,Mridul Kanti Mandal,Tadao Nakazawa,その他9名

Journal of The American Society for Mass Spectrometry   23 ( 10 )   1741 - 1749   2012.10( ISSN：10440305  eISSN：1879-1123 )

Innovations in Analytical Oncology - Status quo of Mass Spectrometry-Based Diagnostics for Malignant Tumor Reviewed

Sen Takeda,Kentaro Yoshimura,Kenzo Hiraoka

Journal of Analytical Oncology   1 ( 1 )   74 - 80   2012.6( ISSN：19277210 )

Hedgehog signaling regulates myelination in the peripheral nervous system through primary cilia Reviewed

Kentaro Yoshimura,Sen Takeda

Differentiation   83 ( 2 )   S78 - S85   2012.2( ISSN：03014681 )

Real time analysis of living animals by electrospray ionization mass spectrometry Reviewed

Kentaro Yoshimura,Lee Chuin Chen,Zhan Yu,Kenzo Hiraoka,Sen Takeda

Analytical Biochemistry   417 ( 2 )   195 - 201   2011.10( ISSN：00032697 )

Signaling through the Primary Cilium Affects Glial Cell Survival under a Stressed Environment. Reviewed

Kentaro Yoshimura,Toyoko Kawate,Sen Takeda

Glia   59 ( 2 )   333 - 344   2011.2( ISSN：08941491 )

Direct analysis of lipids in mouse brain using electrospray droplet impact/SIMS. Reviewed

Asakawa D,Yoshimura K,Takeda S,Hiraoka K.

Journal of Mass Spectrometry   45 ( 4 )   437 - 443   2010.4( ISSN：10765174 )

LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation. Reviewed

Masahiro Shibata,Kentaro Yoshimura,Hirosumi Tamura,Takashi Ueno,その他7名

Biochemical and Biophysical Research Communications   393 ( 2 )   274 - 279   2010.3( ISSN：0006291X )

Ambient imaging mass spectrometry by electrospray ionization using solid needle as sampling probe Reviewed

Lee Chuin Chen,Kentaro Yoshimura,Zhan Yu,Rikiya Iwata,Hajime Ito,その他6名

Journal of Mass Spectrometry   44 ( 10 )   1469 - 1477   2009.10( ISSN：10765174 )

Physical properties of the probe electrospray ionization (PESI) needle applied to the biological samples Reviewed

Kentaro Yoshimura,Lee Chuin Chen,Daiki Asakawa,Kenzo Hiraoka,Sen Takeda

Journal of Mass Spectrometry   44 ( 6 )   978 - 985   2009.6( ISSN：10765174 )

The MAP1-LC3 conjugation system is involved in lipid droplet formation Reviewed

Masahiro Shibata※,Kentaro Yoshimura※,Norihiko Furuya,Masato Koike,Takashi Ueno,その他5名

Biochemical and Biophysical Research Communications   382 ( 2 )   419 - 423   2009.5( ISSN：0006291X )

Hepatic gap junctions in the hepatocarcinogen-resistant DRH rat. Reviewed

Gotow T,Shiozaki M,Higashi T,Yoshimura K,Shibata M,他２名

Histochemistry and Cell Biology   130 ( 3 )   583 - 594   2008.9( ISSN：09486143 )

Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice. Reviewed

Shiozaki M,Yoshimura K,Shibata M,Koike M,Matsuura N,他2名

Neuroscience   152 ( 4 )   924 - 941   2008.4( ISSN：03064522 )

Autophagy-physiology and pathophysiology.

Uchiyama Y,Shibata M,Koike M,Yoshimura K,Sasaki M

Histochemistry and Cell Biology   129 ( 4 )   407 - 420   2008.4( ISSN：09486143  eISSN：1432-119X )

Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues. Reviewed

Yoshimura K,Shibata M,Koike M,Gotoh K,Fukaya M,その他2名

Autophagy   2 ( 3 )   200 - 208   2006.7( ISSN：15548627 )

Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Reviewed Major achievement

Koike M,Shibata M,Waguri S,Yoshimura K,Tanida I,その他7名

The American Journal of Pathology   167 ( 6 )   1713 - 1728   2005.12( ISSN：00029440 )