関西医科大学   肝臓研究所　分子遺伝部門、関西医科大学   講師

1991年12月 - 1997年7月

関西医科大学   肝臓研究所　分子遺伝部門、関西医科大学   助手

1988年4月 - 1991年11月

MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes. 査読

Ogami T, Tamura Y, Toss K, Yuki K, Morikawa M, Tsutsumi S, Aburatani H, Miyazawa K, Miyazono K, Koinuma D.

JOURNAL OF BIOCHEMISTRY   171 ( 4 )   399 - 410   2021年12月( ISSN：0021-924X )

Group V Secretory Phospholipase A 2 Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line. 査読

Fujioka D, Watanabe Y, Nakamura T, Yokoyama T, Miyazawa K, Murakami M, Kugiyama K.

Journal of Atherosclerosis and Thrombosis   29 ( 5 )   692 - 718   2021年3月( ISSN：1340-3478 )

TGF-β-induced cell motility requires down-regulation of ARHGAPs to sustain Rac1 activity. 査読

Motizuki M, Koinuma D, Yokoyama T, Itoh Y, Omata C, Miyazono K, Saitoh M, Miyazawa K.

JOURNAL OF BIOLOGICAL CHEMISTRY   196   100545   2021年3月( ISSN：0021-9258 )

EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression. 査読

Sakamoto K, Endo K, Sakamoto K, Kayamori K, Ehata S, Ichikawa J, Ando T, Nakamura R, Kimura Y, Yoshizawa K, Masuyama K, Kawataki T, Miyake K, Ishii H, Kawasaki T, Miyazawa K, Saitoh M.

Oncogenesis   10 ( 3 )   26   2021年3月( ISSN：2157-9024 )

ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus-dependent E-cadherin downregulation. 査読

Otake S, Itoh Y, Omata C, Saitoh M, Miyazawa K.

CANCER SCIENCE   112 ( 1 )   201 - 216   2021年1月( ISSN：1347-9032 )

Neurotensin receptor 1 signaling promotes pancreatic cancer progression 査読

Takahashi K, Ehata S, Miyauchi K, Morishita Y, Miyazawa K, Miyazono K.

Molecular Oncology   15 ( 1 )   151 - 166   2021年1月( ISSN：1574-7891 )

Structural basis for inhibitory effects of Smad7 on TGF-β family signaling. 査読

Murayama K, Kato-Murayama M, Itoh Y, Miyazono K, Miyazawa K, Shirouzu M.

JOURNAL OF STRUCTURAL BIOLOGY   212 ( 3 )   107661   2020年12月( ISSN：1047-8477 )

TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity. 査読

Nakano N, Sakata N, Katsu Y, Nochise D, Sato E, Takahashi Y, Yamaguchi S, Haga Y, Ikeno S, Motizuki M, Sano K, Yamasaki K, Miyazawa K, Itoh S.

JOURNAL OF BIOLOGICAL CHEMISTRY   295 ( 27 )   9033 - 9051   2020年7月( ISSN：0021-9258 )

Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells 査読

Shibata N, Ohoka N, Tsuji G, Demizu Y, Miyazawa K, Ui-Tei K, Akiyama T, Naito M.

ONCOGENE   39 ( 19 )   3867 - 3878   2020年3月( ISSN：0950-9232 )

Lipidome-based rapid diagnosis with machine learning for detection of TGF-β signalling activated area in head and neck cancer. 査読

Ishii H, Saitoh M, Sakamoto K, Sakamoto K, Saigusa D, Kasai H, Ashizawa K, Miyazawa K, Takeda S, Masuyama K, Yoshimura K.

BRITISH JOURNAL OF CANCER   122 ( 7 )   995 - 1004   2020年2月( ISSN：0007-0920 )

Transgenic Analyses in Drosophila Reveal That mCORL1 Is Functionally Distinct from mCORL2 and dCORL. 査読

Stinchfield MJ, Miyazawa K, Newfeld SJ.

G3-Genes Genomes Genetics   9 ( 11 )   3781 - 3789   2019年11月( ISSN：2160-1836 )

Addiction of mesenchymal phenotypes on the FGF/FGFR axis in oral squamous cell carcinoma cells. 査読

Osada AH, Endo K, Kimura Y, Sakamoto K, Nakamura R, Sakamoto K, Ueki K, Yoshizawa K, Miyazawa K, Saitoh M.

PLoS One   14 ( 11 )   e0217451   2019年11月( ISSN：1932-6203 )

A comparative analysisof Smad-responsive motifs identifies multiple regulatory inputs for TGF-βtranscriptional activation. 査読

Itoh Y, Koinuma D, Omata C, Ogami T, Motizuki M, Yaguchi SI, Itoh T, Miyake K, Tsutsumi S, Aburatani H, Saitoh M, Miyazono K, Miyazawa K.

JOURNAL OF BIOLOGICAL CHEMISTRY   294 ( 42 )   15466 - 15479   2019年10月

Long Noncoding RNA ELIT-1 Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial-Mesenchymal Transition. 査読

Sakai S, Ohhata T, Kitagawa K, Uchida C, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M.

CANCER RESEARCH   79 ( 11 )   2821 - 2838   2019年6月( ISSN：0008-5472 )

Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade. 査読

Suzuki K, Kawataki T, Endo K, Miyazawa K, Kinouchi H, Saitoh M.

Oncology Letters   16 ( 2 )   1758 - 1764   2018年8月( ISSN：1792-1074 )

Reciprocal expression of Slug and Snail in human oral cancer cells. 査読

Nakamura R, Ishii H, Endo K, Hotta A, Fujii E, Miyazawa K, Saitoh M.

PLoS One   13 ( 7 )   e0199442   2018年7月( ISSN：1932-6203 )

Smad3-STAT3 crosstalk in pathophysiological contexts. 招待 査読

Itoh Y, Saitoh M, Miyazawa K.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA   50 ( 1 )   82 - 90   2018年1月( ISSN：1672-9145 )

Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion. 査読

Furuya S, Endo K, Takahashi A, Miyazawa K, Saitoh M.

FEBS Open Bio   7 ( 10 )   1586 - 1597   2017年9月( ISSN：2211-5463 )

Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cells. 査読

Sinh ND, Endo K, Miyazawa K, Saitoh M

CANCER SCIENCE   108 ( 5 )   952 - 960   2017年5月( ISSN：1347-9032 )

Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma. 査読

Makino Y, Yoon JH, Bae E, Kato M, Miyazawa K, Ohira T, Ikeda N, Kuroda M, Mamura M.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   484 ( 2 )   269 - 277   2017年3月( ISSN：0006-291X )

Regulation of TGF-β Family Signaling by Inhibitory Smads 招待 査読

Miyazawa, K. and Miyazono, K

Cold Spring Harbor Perspectives in Biology   9 ( 3 )   a022095   2017年3月( ISSN：1943-0264 )

Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression. 招待 査読

Hayakawa A, Saitoh M, Miyazawa K.

Advances in Experimental Medicine and Biology   925   33 - 40   2016年7月( ISSN：0065-2598 )

STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression. 査読

Saitoh M, Endo K, Furuya S, Minami M, Fukasawa A, Imamura T, Miyazawa K.

ONCOGENE   35 ( 8 )   1049 - 1057   2016年2月( ISSN：0950-9232 )

The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins. 査読

Hoshi Y, Endo K, Shirakihara T, Fukagawa A, Miyazawa K, Saitoh M.

FEBS Lett.   590 ( 2 )   270 - 278   2016年1月( ISSN：0014-5793 )

Maid is a negative regulator of transforming growth factor-β-induced cell migration. 査読

Motizuki M, Saitoh M, Miyazawa K.

JOURNAL OF BIOCHEMISTRY   158 ( 5 )   435 - 444   2015年11月( ISSN：0021-924X )

Arkadia enhances BMP signalling through ubiquitylation and degradation of Smad6. 査読

Tsubakihara Y, Hikita A, Yamamoto S, Matsushita S, Matsushita N, Oshima Y, Miyazawa K, Imamura T.

J. Biochem.   158 ( 1 )   61 - 71   2015年7月

δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells. 査読

Fukagawa A, Ishii H, Miyazawa K, Saitoh M

Cancer Med.   4 ( 1 )   125 - 135   2015年1月

Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms. 査読

Ishii H, Saitoh M, Sakamoto K, Kondo T, Katoh R,T Tanaka S, Motizuki M, Masuyama K, Miyazawa K.

JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 40 )   27386 - 27399   2014年10月( ISSN：0021-9258 )

A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression. 査読

Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.

CELL RESEARCH   24 ( 8 )   994 - 1008   2014年8月( ISSN：1001-0602 )

HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor. 査読

Sakata K, Hara M, Terada T, Watanabe N, Takaya D, Yaguchi S, Matsumoto T, Matsuura T, Shirouzu M, Yokoyama S, Yamaguchi T, Miyazawa K, Aizaki H, Suzuki T, Wakita T, Imoto M, Kojima S.

Sci Rep.   3   3243   2013年11月

Identification of integrin α3 as a molecular marker of cells undergoing EMT and of cancer cells with aggressive phenotypes. 査読

Shirakihara T, Kawasaki T, Fukagawa A, Semba K, Sakai R, Miyazono K, Miyazawa K, Saitoh M.

Cancer Sci.   104 ( 9 )   1189 - 1197   2013年9月

Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β 査読

Motizuki M, Isogaya K, Miyake K, Ikushima H, Kubota T, Miyazono K, Saitoh M, Miyazawa K.

JOURNAL OF BIOLOGICAL CHEMISTRY   288 ( 26 )   18911 - 18922   2013年6月( ISSN：0021-9258 )

Basolateral BMP signaling in polarized epithelial cells. 査読

Saitoh M, Shirakihara T, Fukasawa A, Horiguchi K, Sakamoto K, Sugiya H, Beppu H, Fujita Y, Morita I, Miyazono K, Miyazawa K.

PLos One   8 ( 5 )   e6265   2013年5月

Phosphoinositide 5-phosphatases: how do they affect tumorigenesis? 招待 査読

Miyazawa, K.

J. Biochem.   153 ( 1 )   1 - 3   2013年1月

A negative regulator or just an unconcerned passerby: phosphoinositide 3-kinase signaling in IL-12 production. 招待 査読

Miyazawa, K.

J. Biochem.   152 ( 6 )   497 - 499   2012年12月

TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP. 査読

Horiguchi, K.,Sakamoto, K.,Koinuma, D.,Semba, K.,Inoue, A.,Inoue, S.,Fujii, H.,Yamaguchi, A.,Miyazawa, K.,Miyazono K.,Saitoh, M.

Oncogene   31 ( 26 )   3190 - 3201   2012年6月

Transcriptional and post-transcriptional regulation of TGF-β mediated epithelial-mesenchymal transition 査読

Saitoh M, Miyazawa K

J. Biochem.   151 ( 6 )   563 - 571   2012年5月

Phosphorylation in the activation loop as the finishing touch in c-Kit activation. 査読

Miyazawa, K.

J. Biochem.   151 ( 5 )   457 - 459   2012年5月

Structure of dominant-negative helix-loop-helix transcriptional regulator HHM representing the autoinhibition state. 査読

Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi SI, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O.

EMBO J.   30 ( 4 )   783 - 795   2012年3月

Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4. 査読

Ikushima, H.,Todo, T.,Ino, Y.,Takahashi, M.,Saito, N.,Miyazawa, K.,Miyazono, K.

J. Biol. Chem.   286 ( 48 )   41434 - 41441   2011年12月

RB1CC1 positively regulates TGF-β signaling through modulation of Arkadia E3 ubiquitin ligase activity. 査読

Koinuma, D., Shinozaki, M.,Nagano, Y.,Ikushima, H.,Horiguchi, K.,Goto, K.,Chano, T.,Saitoh, M.,Imamura, T.,Miyazono, K.,Miyazawa, K.

J. Biol. Chem.   286   32502 - 32512   2011年9月

Encountering unpredicted off-target effects of pharmacological inhibitors. 査読

Keiji Miyazawa

J. Biochem.   150 ( 1 )   1 - 3   2011年7月

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1. 査読

Inoue, Y.,Iemura, S-i.,Natsume, T.,Miyazawa, K.,Imamura, T.

J. Biol. Chem.   286 ( 8 )   6311 - 6320   2011年2月

TGF-β regulates FGF receptor isoform switching and epithelial-mesenchymal transition. 査読

Shirakihara, T.,Horiguchi, K.,Miyazawa, K.,Ehata, S.,Shibata, T.,Morita, I.,Miyazono, K.,Saitoh, M.

EMBO JOURNAL   30   783 - 795   2011年2月( ISSN：0261-4189 )

Dissecting the signal transduction pathway that directs endothelial differentiation using embryonic stem cell-derived vascular progenitor cells.

Kawasaki K, and Miyazawa K.

Embryonic Stem Cells -- Differentiation and Pluripotent Alternatives (ed. by Michael S. Kallos)   245 - 266   2011年

Arkadia complexes with clathrin adaptor AP2 and regulates EGF signaling. 査読

Mizutani, A,Saitoh, M,Imamura, T.,Miyazawa, K.,MIyazono, K.l

J. Biochem.   148 ( 6 )   733 - 741   2010年12月

Smad 7 inhibits transforming growth factor-β family type I receptors through two distinct modes of interaction. 査読

Kamiya, Y.,Miyazono, K.,Miyazawa, K.

J. Biol. Chem.   285 ( 40 )   30804 - 30813   2010年10月

Identification of a phosphorylation site in c-Ski as serine 515. 査読

Nagata, M.,Nagata, S.,Yuki, K.,Isogaya, K.,Saitoh, M.,Miyazono, K.,Miyazawa, K.

J. Biochem.   148 ( 4 )   423 - 427   2010年10月

Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. 査読

Miyazawa K.

FEBS J.   277 ( 10 )   2208 - 2214   2010年5月

Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells. 査読

Nagano Y,Koinuma D,Miyazawa K,Miyazono K

JOURNAL OF BIOCHEMISTRY   147 ( 4 )   545 - 554   2010年4月( ISSN：0021-924X )

Autocrine TGF-β signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. 査読

Ikushima H, Todo T, Ino T, Takahashi T, Miyazawa K, Miyazono K.

Cell Stem Cell   5   504 - 514   2009年11月

Functional in vivo optical imaging of tumor angiogenesis, growth and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells. 査読

Hanyu A, Kojima K, Hatake K, Nomura K, Murayama H, Ishikawa Y, Miyata S, Ushijima M, Matsuura M, Ogata E, Miyazawa K, Imamura T.

Cancer Sci.   100 ( 11 )   2085 - 2092   2009年11月

VEGFR2-PLCγ1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells. 査読

Sase H, Watabe T, Kawasaki K, Miyazono K, Miyazawa K.

J. Cell Sci.   122   3303 - 3311   2009年9月

Pin1 binds to Smad2/3 and induces Smurf2-mediated degradation of Smad2/3 to down-regulate TGF-β signaling. 査読

Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T.

J. Biol. Chem.   284   6109 - 6115   2009年3月

The E3 ubiquitin-ligase WWP1 selectively targets HER4 and its proteolytic-derived signaling isoforms for degradation. 査読

Feng SM, Muraoka-Cook RS, Hunter D, Sandahl MA, Caskey LS, Miyazawa K, Atfi A, Earp HS 3rd.

Mol. Cell. Biol.   29 ( 3 )   892 - 906   2009年2月

SKI and MEL1 cooperate to inhibit transforming growth factor-β signal in gastric cancer cells. 査読

Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K, Imamura T.

J. Biol. Chem.   284   3334 - 3344   2009年1月

Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling 査読

Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, Sunamura M, Imamura T, Miyazono K, Aburatani H.

Mol. Cell. Biol.   29 ( 1 )   172 - 186   2009年1月

Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator. 査読

Seto A, Ikushima H, Suzuki T, Sato Y, Fukai S, Yuki K, Miyazawa K, Miyazono K, Ishitani R, Nureki O.

Acta Crystal.   F65   21 - 24   2009年1月

Arkadia represses myoblast differentiation through degradation of Ski and the Ski-bound Smad complex. 査読

Yuzawa H, Koinuma D, Maeda S, Yamamoto K, Miyazawa K, Imamura T.

Bone   44   53 - 60   2009年1月

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. 査読

Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T.

J. Biol. Chem.   283   35660 - 35667   2008年12月

An Id-like molecule, HHM, is a syn-expression group-restricted regulator of TGF-β signalling. 査読

Ikushima H, Komuro A, Isogaya K, Shinozaki M, Hellman U, Miyazawa K, Miyazono K.

EMBO J.   27   2955 - 2965   2008年11月

Specificity of inhibitory effects of Dad on TGF-β family type I receptors in Drosophila. 査読

Kamiya Y, Miyazono K, Miyazawa K.

FEBS Lett.   582   2496 - 2500   2008年7月

Activation of MET receptor tyrosine kinase in ulcer surface epithelial cells undergoing restitution. 査読

Nagai M, Takahashi N, Miyazawa K, Kawaguchi M, Chijiiwa K, Kataoka H.

Pathol. Int.   58   462 - 464   2008年7月

SUMO amplifies TGF-beta signalling. 査読

Miyazono K, Kamiya Y, Miyazawa

Nat Cell Biol   10 ( 6 )   635 - 637   2008年6月

Ras signaling specifies endothelial differentiation of VEGFR2+ vascular progenitor cells. 査読

Kawasaki K, Watabe T, Sase H, Hirashima M, Koide H, Morishita Y, Yuki K, Sasaoka T, Suda T, Katsuki M, Miyazono K, Miyazawa K.

J. Cell Biol.   181   131 - 141   2008年4月

Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCFFWD1/β-TrCP-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1. 査読

Hayakawa M, Matsushima M, Hagiwara H, Oshima T, Fujino T, Ando K, Kikugawa K, Tanaka H, Miyazawa K, Kitagawa M.

Genes Cells   13   329 - 342   2008年4月

Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines. 査読

Nakamura Y, Matsubara D, Goto A, Ota S, Sachiko O, Ishikawa S, Aburatani H, Miyazawa K, Fukayama M, Niki T.

Cancer Sci.   99 ( 1 )   14 - 22   2008年1月

Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. 査読

Ehata S, Hanyu A, Hayashi M, Aburatani H, Kato Y, Fujime M, Saitoh M, Miyazawa K, Imamura T, Miyazono K.

Cancer Res.   67 ( 20 )   9694 - 9703   2007年10月

Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors. 査読

Goto K, Kamiya Y, Imamura T, Miyazono K, Miyazawa K.

J Biol Chem.   282 ( 28 )   20603 - 20611   2007年7月

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling. 査読

Nagano Y, Mavrakis KJ, Lee KL, Fujii T, Koinuma D, Sase H, Yuki K, Isogaya K, Saitoh M, Imamura T, Episkopou V, Miyazono K, Miyazawa K.

J Biol Chem.   282 ( 28 )   20492 - 20501   2007年7月

c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis. 査読

Nakamura Y, Niki T, Goto A, Morikawa T, Miyazawa K, Nakajima J, Fukayama M.

Cancer Sci.   98 ( 7 )   1006 - 1013   2007年7月

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases. 査読

Kobayashi N, Goto K, Horiguchi K, Nagata M, Kawata M, Miyazawa K, Saitoh M, Miyazono K.

Genes Cells   12 ( 3 )   375 - 385   2007年3月

Inhibitory effect of c-Met mutants on the formation of branching tubules by a porcine aortic endothelial cell line. 査読

Maemura M, Yoshimoto A, Tsukada Y, Morishita Y, Miyazawa K, Tanaka T, Kitamura N.

Cancer Sci.   97 ( 12 )   1343 - 1350   2006年12月

Nuclear and cytoplasmic c-Ski differently modulate cellular functions. 査読

Nagata M, Goto K, Ehata S, Kobayashi N, Saitoh M, Miyoshi H, Imamura T, Miyazawa K, Miyazono K.

Genes Cells.   11 ( 11 )   1267 - 1280   2006年11月

VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling. 査読

Kano MR, Morishita Y, Iwata C, Iwasaka S, Watabe T, Ouchi Y, Miyazono K, Miyazawa K.

J Cell Sci.   118 ( 16 )   3759 - 3768   2005年8月

Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta. 査読

Tanaka H, Nagaike K, Takeda N, Itoh H, Kohama K, Fukushima T, Miyata S, Uchiyama S, Uchinokura S, Shimomura T, Miyazawa K, Kitamura N, Yamada G, Kataoka H.

Mol Cell Biol.   25 ( 13 )   5687 - 5698   2005年7月

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. 査読

Kuratomi G, Komuro A, Goto K, Shinozaki M, Miyazawa K, Miyazono K, Imamura T.

Biochem J   386 ( 3 )   461 - 470   2005年3月

Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells. 査読

Suzuki H, Watabe T, Kato M, Miyazawa K, Miyazono K.

Blood   105 ( 6 )   2372 - 2379   2005年3月

The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1. 査読

Hayakawa M, Kitagawa H, Miyazawa K, Kitagawa M, Kikugawa K.

Genes Cells   10 ( 3 )   241 - 251   2005年3月

Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice. 査読

Itoh H, Naganuma S, Takeda N, Miyata S, Uchinokura S, Fukushima T, Uchiyama S, Tanaka H, Nagaike K, Shimomura T, Miyazawa K, Yamada G, Kitamura N, Koono M, Kataoka H.

Gastroenterology   127 ( 5 )   1423 - 1435   2004年11月

Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2. 査読

Tsukada Y, Tanaka T, Miyazawa K, Kitamura N.

J Biochem   136 ( 5 )   701 - 709   2004年11月

Activation of c-Met (hepatocyte growth factor receptor) in human gastric cancer tissue. 査読

Inoue T, Kataoka H, Goto K, Nagaike K, Igami K, Naka D, Kitamura N, Miyazawa K.

Cancer Sci.   95 ( 10 )   803 - 808   2004年10月

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K, Miyazawa K.

Oncogene   23 ( 41 )   6914 - 6923   2004年9月

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements. 査読

Suzuki H, Yagi K, Kondo M, Kato M, Miyazono K, Miyazawa K.

Oncogene   23 ( 29 )   5068 - 5076   2004年6月

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. 査読

Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H, Fujita T, Imamura T, Miyazono K, Miyazawa K.

Mol Biol Cell   15 ( 3 )   963 - 972   2004年3月

Activation of hepatocyte growth factor in monkey stomach following gastric mucosal injury. 査読

Hori T, Ido A, Uto H, Hasuike S, Moriuchi A, Hayashi K, Nakagawa S, Miyazawa K, Kitamura N, Tsubouchi H.

J Gastroenterol   39 ( 2 )   133 - 139   2004年

TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. 査読

Watabe T, Nishihara A, Mishima K, Yamashita J, Shimizu K, Miyazawa K, Nishikawa S, Miyazono K.

J Cell Biol   163 ( 6 )   1303 - 1311   2003年12月

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. 査読

Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K.

EMBO J   22 ( 24 )   6458 - 6470   2003年12月

Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain. 査読

Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N.

J Biol Chem   278 ( 48 )   48162 - 48168   2003年11月

SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.

Matsuyama S, Iwadate M, Kondo M, Saitoh M, Hanyu A, Shimizu K, Aburatani H, Mishima HK, Imamura T, Miyazono K, Miyazawa K. SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.

Cancer Res   63 ( 22 )   7791 - 7798   2003年11月

A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. 査読

Inomata H, Nakamura Y, Hayakawa A, Takata H, Suzuki T, Miyazawa K, Kitamura N.

J Biol Chem   278 ( 25 )   22946 - 22955   2003年6月

Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN. 査読

Mizuide M, Hara T, Furuya T, Takeda M, Kusanagi K, Inada Y, Mori M, Imamura T, Miyazawa K, Miyazono K.

J Biol Chem   278 ( 1 )   531 - 536   2003年1月

Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells. 査読

Ota T, Fujii M, Sugizaki T, Ishii M, Miyazawa K, Aburatani H, Miyazono K.

J Cell Physiol   193 ( 3 )   299 - 318   2002年12月

Two major Smad pathways in TGF-beta superfamily signalling. 査読

Miyazawa K, Shinozaki M, Hara T, Furuya T, Miyazono K.

Genes Cells   7 ( 12 )   1191 - 1204   2002年12月

Id: a target of BMP signaling. 査読

Miyazono K, Miyazawa K.

Sci STKE   151   PE40   2002年9月

Impairment of activation of hepatocyte growth factor precursor into its mature form in rats with liver cirrhosis. 査読

Kaibori M, Inoue T, Sakakura Y, Oda M, Nagahama T, Kwon AH, Kamiyama Y, Miyazawa K, Okumura T.

J Surg Res   106 ( 1 )   108 - 114   2002年7月

Denda K, Shimomura T, Kawaguchi T, Miyazawa K, Kitamura N. Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1. 査読

Denda K, Shimomura T, Kawaguchi T, Miyazawa K, Kitamura N.

J Biol Chem   277 ( 16 )   14053 - 14059   2002年4月

Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF. 査読

Kaibori M, Inoue T, Oda M, Naka D, Kawaguchi T, Kitamura N, Miyazawa K, Kwon AH, Kamiyama Y, Okumura T.

Biochem Biophys Res Commun   290 ( 1 )   475 - 481   2002年1月

High intensity ERK signal mediates hepatocyte growth factor-induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2. 査読

Tsukada Y, Miyazawa K, Kitamura N.

J Biol Chem   276 ( 44 )   40968 - 40976   2001年11月

Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. 査読

Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M.

Biochem Biophys Res Commun   288 ( 2 )   390 - 399   2001年10月

Regulation of hepatocyte growth factor (HGF) activation on cell surface: Insights into an emerging class of cell surface protease inhibitors. 査読

Kataoka H, Itoh H, Shimomura T, Nuki Y, Naganuma S, Miyazawa K.

Int Arch Biosci   1036 - 1042   2001年

Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. 査読

Kataoka H, Shimomura T, Kawaguchi T, Hamasuna R, Itoh H, Kitamura N, Miyazawa K, Koono M.

J Biol Chem   275 ( 51 )   40453 - 40462   2000年12月

A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. 査読

Kato M, Miyazawa K, Kitamura N.

J Biol Chem   275 ( 48 )   37481 - 37487   2000年12月

Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract. 査読

Itoh H, Hamasuna R, Kataoka H, Yamauchi M, Miyazawa K, Kitamura N, Koono M.

Biochim Biophys Acta   1491 ( 1-3 )   295 - 302   2000年4月

Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency. 査読

Leppanen O, Miyazawa K, Backstrom G, Pietras K, Sjoblom T, Heldin CH, Ostman A.

Biochemistry   39 ( 9 )   2370 - 2375   2000年3月

Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form. 査読

Shimomura T, Denda K, Kawaguchi T, Matsumoto K, Miyazawa K, Kitamura N.

J Biochem   126 ( 5 )   821 - 828   1999年11月

Molecular cloning and characterization of a novel protein serine/threonine kinase highly expressed in mouse embryo. 査読

Kurioka K, Nakagawa K, Denda K, Miyazawa K, Kitamura N.

Biochim Biophys Acta   1443 ( 3 )   275 - 284   1998年12月

Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator. 査読

Miyazawa K, Wang Y, Minoshima S, Shimizu N, Kitamura N.

Eur J Biochem   258 ( 2 )   335 - 361   1998年12月

Role of immunoglobulin-like domains 2-4 of the platelet-derived growth factor alpha-receptor in ligand-receptor complex assembly. 査読

Miyazawa K, Backstrom G, Leppanen O, Persson C, Wernstedt C, Hellman U, Heldin CH, Ostman A.

J Biol Chem   273 ( 39 )   25495 - 25502   1998年9月

Identification of a 190-kDa vascular endothelial growth factor 165 cell surface binding protein on a human glioma cell line. 査読

Omura T, Miyazawa K, Ostman A, Heldin CH.

J Biol Chem   272 ( 37 )   23317 - 23322   1997年9月

Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. 査読

Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N.

J Biol Chem   272 ( 10 )   6370 - 6376   1997年3月

Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation. 査読

Okajima A, Miyazawa K, Naitoh Y, Inoue K, Kitamura N.

Hepatology   25 ( 1 )   97 - 102   1997年1月

Production and activation of hepatocyte growth factor during the healing of rat gastric ulcers. 査読

Kinoshita Y, Kishi K, Asahara M, Matasushima Y, Wang HY, Miyazawa K, Kitamura N, Chiba T.

Digestion   58 ( 3 )   225 - 231   1997年

Purification and characterization of a novel protease inhibitor specific to hepatocyte growth factor activator.

Kawaguchi T, Shimomura T, Denda K, Kitamura A, Kondo J, Kito M, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N.

Animal Cell Technology: Basic & Applied Aspects   8   403 - 407   1997年

Hepatocyte growth factor (HGF)-induced cell migration is negatively modulated by epidermal growth factor through tyrosine phosphorylation of the HGF receptor. 査読

Takeuchi K, Shibamoto S, Hayakawa M, Hori T, Miyazawa K, Kitamura N, Ito F.

Exp Cell Res   223 ( 2 )   420 - 425   1996年3月

Dissociation of c-fos induction and mitogen-activated-protein kinase activation from the hepatocyte-growth-factor-induced motility response in human gastric carcinoma cells. 査読

Nagamine K, Shibamoto S, Takeuchi K, Miyazawa K, Kitamura N, Chatani Y, Kohno M, Ito F.

Eur J Biochem   236 ( 2 )   476 - 481   1996年3月

Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. 査読

Miyazawa K, Shimomura T, Kitamura N.

J Biol Chem   271 ( 7 )   3615 - 3618   1996年2月

Hepatocyte growth factor remains as an inactive single chain after partial hepatectomy or unilateral nephrectomy. 査読

Tang W, Miyazawa K, Kitamura N.

FEBS Lett   362 ( 2 )   220 - 224   1995年4月

Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator.

Shimomura T, Miyazawa K, Komiyama Y, Hiraoka H, Naka D, Morimoto Y, Kitamura N.

Eur J Biochem   229 ( 1 )   257 - 261   1995年4月

Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. 査読

Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M, Ito F.

J Cell Biol   128 ( 5 )   949 - 957   1995年3月

Proteolytic activation of hepatocyte growth factor in response to tissue injury. 査読

Miyazawa K, Shimomura T, Naka D, Kitamura N.

J Biol Chem   269 ( 12 )   8966 - 8970   1994年3月

Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. 査読

Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Oku N, Miyazawa K, Kitamura N, Takeichi M, Ito F.

Cell Adhes Commun   1 ( 4 )   295 - 305   1994年1月

Stimulation of prostaglandin production by hepatocyte growth factor in human gastric carcinoma cells. 査読

Hori T, Shibamoto S, Hayakawa M, Takeuchi K, Oku N, Miyazawa K, Kitamura N, Ito F.

FEBS Lett   334 ( 3 )   331 - 334   1993年11月

Activation of the zymogen of hepatocyte growth factor activator by thrombin. 査読

Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N.

J Biol Chem   268 ( 30 )   22927 - 22932   1993年10月

Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. 査読

Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N.

J Biol Chem   268 ( 30 )   22927 - 22932   1993年5月

Characterization of the promoter region of the rat hepatocyte-growth-factor/scatter-factor gene. 査読

Okajima A, Miyazawa K, Kitamura N.

Eur J Biochem   213 ( 1 )   113 - 119   1993年4月

Gene expression and regulation of HGF-SF. 査読

Kitamura N, Miyazawa K, Uehara Y, Komada M, Okajima A, Okigaki M, Kitamura A.

Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the c-Met Receptor. (ed. by Goldberg and Rosen)   49 - 65   1993年

Functional characterization of human hepatocyte growth factor mutants obtained by deletion of structural domains. 査読

Okigaki M, Komada M, Uehara Y, Miyazawa K, Kitamura N.

Biochemistry   31 ( 40 )   9555 - 9561   1992年10月

Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. 査読

Naka D, Ishii T, Yoshiyama Y, Miyazawa K, Hara H, Hishida T, Kitamura N.

J Biol Chem   267 ( 28 )   20114 - 20119   1992年10月

Hepatocyte growth factor and transforming growth factor-beta stimulate both cell growth and migration of human gastric adenocarcinoma cells. 査読

Shibamoto S, Hayakawa M, Hori T, Oku N, Miyazawa K, Kitamura N, Ito F.

Cell Struct Funct   17 ( 3 )   185 - 190   1992年6月

Characterization of hepatocyte-growth-factor receptors on Meth A cells. 査読

Komada M, Miyazawa K, Ishii T, Kitamura N.

Eur J Biochem   204 ( 2 )   857 - 864   1992年3月

Hepatocyte growth factor in blood and liver in mice treated with hepatotoxins

Gohda E, Hayashi Y, Miyazawa K, Kitamura N, Yamamoto I.

Frontiers of mucosal immunology   1   101 - 104   1992年

Structural organization and the transcription initiation site of the human hepatocyte growth factor gene.

Miyazawa K, Kitamura A, Kitamura N.

Biochemistry   30 ( 38 )   9170 - 9176   1991年9月

An alternatively processed mRNA generated from human hepatocyte growth factor gene. 査読

Miyazawa K, Kitamura A, Naka D, Kitamura N.

Eur J Biochem   197 ( 1 )   15 - 22   1991年4月

Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury. 査読

Okajima A, Miyazawa K, Kitamura N.

Eur J Biochem   193 ( 2 )   375 - 381   1990年10月

Complement activation induced by human C-reactive protein in mildly acidic conditions. 査読

Miyazawa K, Inoue K.

J Immunol   145 ( 2 )   15 - 22   1990年7月

Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. 査読

Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K, Goda E, Daikuhara Y, Kitamura N.

Biochem Biophys Res Commun   163 ( 2 )   967 - 973   1989年9月

Modulation of stimulus-dependent human platelet activation by C-reactive protein modified with active oxygen species. 査読

Miyazawa K, Kiyono S, Inoue K.

J Immunol   141 ( 2 )   570 - 574   1988年7月

進化するがん創薬

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化学同人  2019年6月 

人体の細胞生物学

（坂井、石崎　編）（ 担当： 分担執筆 範囲: 3-4, 4-2）

日本医事新報社  2018年11月  （  ISBN:978-4-7849-3232-0 ）

臨床生化学（第５版）

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メディカ出版  2018年1月 

デヴィータ　がんの分子生物学　第２版

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メディカル　サイエンス　インターナショナル  2017年5月 

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宮園浩平,秋山徹,宮島篤,宮澤恵二（ 担当： 共編者 範囲: -）

羊土社  2015年4月 

カラー生化学　第４版

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西村書店  2015年3月 

からだのなぜ？がわかる　生化学・生理学　超基本

岩田英里子　著,宮澤恵二　監修（ 担当： 監修 範囲: -）

メディカ出版  2013年11月 

TGF-β in human disease

Aristidis Moustakas and Keiji Miyazawa Eds.（ 担当： 共編者 範囲: -）

Springer Japan  2013年7月 

デヴィータ　がんの分子生物学

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医歯薬出版株式会社  2010年9月 

細胞の個性に応じて機能するTGF-βファミリー

企画：宮澤恵二, 伊東進（ 担当： 共編者）

羊土社  2010年3月 

分子細胞生物学辞典（第２版）

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東京化学同人  2008年10月 

タンパク質の事典

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廣川書店  2008年7月 

細胞生物学概論

2017年度  科目区分：博士（大学院）

生化学B

2017年度  科目区分：専門教育（学部）