Kansai Medical University   Senior Assistant Professor

1991.12 - 1997.7

Kansai Medical University   Research Associate

1988.4 - 1991.11

MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes. Reviewed

Ogami T, Tamura Y, Toss K, Yuki K, Morikawa M, Tsutsumi S, Aburatani H, Miyazawa K, Miyazono K, Koinuma D.

JOURNAL OF BIOCHEMISTRY   171 ( 4 )   399 - 410   2021.12( ISSN：0021-924X )

Group V Secretory Phospholipase A 2 Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line. Reviewed

Fujioka D, Watanabe Y, Nakamura T, Yokoyama T, Miyazawa K, Murakami M, Kugiyama K.

Journal of Atherosclerosis and Thrombosis   29 ( 5 )   692 - 718   2021.3( ISSN：1340-3478 )

TGF-β-induced cell motility requires down-regulation of ARHGAPs to sustain Rac1 activity. Reviewed

Motizuki M, Koinuma D, Yokoyama T, Itoh Y, Omata C, Miyazono K, Saitoh M, Miyazawa K.

JOURNAL OF BIOLOGICAL CHEMISTRY   196   100545   2021.3( ISSN：0021-9258 )

EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression. Reviewed

Sakamoto K, Endo K, Sakamoto K, Kayamori K, Ehata S, Ichikawa J, Ando T, Nakamura R, Kimura Y, Yoshizawa K, Masuyama K, Kawataki T, Miyake K, Ishii H, Kawasaki T, Miyazawa K, Saitoh M.

Oncogenesis   10 ( 3 )   26   2021.3( ISSN：2157-9024 )

ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus-dependent E-cadherin downregulation. Reviewed

Otake S, Itoh Y, Omata C, Saitoh M, Miyazawa K.

CANCER SCIENCE   112 ( 1 )   201 - 216   2021.1( ISSN：1347-9032 )

Neurotensin receptor 1 signaling promotes pancreatic cancer progression Reviewed

Takahashi K, Ehata S, Miyauchi K, Morishita Y, Miyazawa K, Miyazono K.

Molecular Oncology   15 ( 1 )   151 - 166   2021.1( ISSN：1574-7891 )

Structural basis for inhibitory effects of Smad7 on TGF-β family signaling. Reviewed

Murayama K, Kato-Murayama M, Itoh Y, Miyazono K, Miyazawa K, Shirouzu M.

JOURNAL OF STRUCTURAL BIOLOGY   212 ( 3 )   107661   2020.12( ISSN：1047-8477 )

TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity. Reviewed

Nakano N, Sakata N, Katsu Y, Nochise D, Sato E, Takahashi Y, Yamaguchi S, Haga Y, Ikeno S, Motizuki M, Sano K, Yamasaki K, Miyazawa K, Itoh S.

JOURNAL OF BIOLOGICAL CHEMISTRY   295 ( 27 )   9033 - 9051   2020.7( ISSN：0021-9258 )

Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells Reviewed

Shibata N, Ohoka N, Tsuji G, Demizu Y, Miyazawa K, Ui-Tei K, Akiyama T, Naito M.

ONCOGENE   39 ( 19 )   3867 - 3878   2020.3( ISSN：0950-9232 )

Lipidome-based rapid diagnosis with machine learning for detection of TGF-β signalling activated area in head and neck cancer. Reviewed

Ishii H, Saitoh M, Sakamoto K, Sakamoto K, Saigusa D, Kasai H, Ashizawa K, Miyazawa K, Takeda S, Masuyama K, Yoshimura K.

BRITISH JOURNAL OF CANCER   122 ( 7 )   995 - 1004   2020.2( ISSN：0007-0920 )

Transgenic Analyses in Drosophila Reveal That mCORL1 Is Functionally Distinct from mCORL2 and dCORL. Reviewed

G3-Genes Genomes Genetics   9 ( 11 )   3781 - 3789   2019.11( ISSN：2160-1836 )

Addiction of mesenchymal phenotypes on the FGF/FGFR axis in oral squamous cell carcinoma cells. Reviewed

Osada AH, Endo K, Kimura Y, Sakamoto K, Nakamura R, Sakamoto K, Ueki K, Yoshizawa K, Miyazawa K, Saitoh M.

PLoS One   14 ( 11 )   e0217451   2019.11( ISSN：1932-6203 )

A comparative analysisof Smad-responsive motifs identifies multiple regulatory inputs for TGF-βtranscriptional activation. Reviewed

Itoh Y, Koinuma D, Omata C, Ogami T, Motizuki M, Yaguchi SI, Itoh T, Miyake K, Tsutsumi S, Aburatani H, Saitoh M, Miyazono K, Miyazawa K.

JOURNAL OF BIOLOGICAL CHEMISTRY   294 ( 42 )   15466 - 15479   2019.10

Long Noncoding RNA ELIT-1 Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial-Mesenchymal Transition. Reviewed

Sakai S, Ohhata T, Kitagawa K, Uchida C, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M.

CANCER RESEARCH   79 ( 11 )   2821 - 2838   2019.6( ISSN：0008-5472 )

Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade. Reviewed

Suzuki K, Kawataki T, Endo K, Miyazawa K, Kinouchi H, Saitoh M.

Oncology Letters   16 ( 2 )   1758 - 1764   2018.8( ISSN：1792-1074 )

Reciprocal expression of Slug and Snail in human oral cancer cells. Reviewed

Nakamura R, Ishii H, Endo K, Hotta A, Fujii E, Miyazawa K, Saitoh M.

PLoS One   13 ( 7 )   e0199442   2018.7( ISSN：1932-6203 )

Smad3-STAT3 crosstalk in pathophysiological contexts. Invited Reviewed

Itoh Y, Saitoh M, Miyazawa K.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA   50 ( 1 )   82 - 90   2018.1( ISSN：1672-9145 )

Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion. Reviewed

Furuya S, Endo K, Takahashi A, Miyazawa K, Saitoh M.

FEBS Open Bio   7 ( 10 )   1586 - 1597   2017.9( ISSN：2211-5463 )

Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cells. Reviewed

Sinh ND, Endo K, Miyazawa K, Saitoh M

CANCER SCIENCE   108 ( 5 )   952 - 960   2017.5( ISSN：1347-9032 )

Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma. Reviewed

Makino Y, Yoon JH, Bae E, Kato M, Miyazawa K, Ohira T, Ikeda N, Kuroda M, Mamura M.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   484 ( 2 )   269 - 277   2017.3( ISSN：0006-291X )

Regulation of TGF-β Family Signaling by Inhibitory Smads Invited Reviewed

Miyazawa, K. and Miyazono, K

Cold Spring Harbor Perspectives in Biology   9 ( 3 )   a022095   2017.3( ISSN：1943-0264 )

Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression. Invited Reviewed

Hayakawa A, Saitoh M, Miyazawa K.

Advances in Experimental Medicine and Biology   925   33 - 40   2016.7( ISSN：0065-2598 )

STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression. Reviewed

Saitoh M, Endo K, Furuya S, Minami M, Fukasawa A, Imamura T, Miyazawa K.

ONCOGENE   35 ( 8 )   1049 - 1057   2016.2( ISSN：0950-9232 )

The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins. Reviewed

FEBS LETTERS   590 ( 2 )   270 - 278   2016.1( ISSN：0014-5793 )

Maid is a negative regulator of transforming growth factor-β-induced cell migration. Reviewed

Motizuki M, Saitoh M, Miyazawa K.

JOURNAL OF BIOCHEMISTRY   158 ( 5 )   435 - 444   2015.11( ISSN：0021-924X )

Arkadia enhances BMP signalling through ubiquitylation and degradation of Smad6. Reviewed

J. Biochem.   158 ( 1 )   61 - 71   2015.7

δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells. Reviewed

Cancer Med.   4 ( 1 )   125 - 135   2015.1

Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms. Reviewed

Ishii H, Saitoh M, Sakamoto K, Kondo T, Katoh R,T Tanaka S, Motizuki M, Masuyama K, Miyazawa K.

JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 40 )   27386 - 27399   2014.10( ISSN：0021-9258 )

A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression. Reviewed

Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.

CELL RESEARCH   24 ( 8 )   994 - 1008   2014.8( ISSN：1001-0602 )

HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor. Reviewed

Sakata K, Hara M, Terada T, Watanabe N, Takaya D, Yaguchi S, Matsumoto T, Matsuura T, Shirouzu M, Yokoyama S, Yamaguchi T, Miyazawa K, Aizaki H, Suzuki T, Wakita T, Imoto M, Kojima S.

Sci Rep.   3   3243   2013.11

Identification of integrin α3 as a molecular marker of cells undergoing EMT and of cancer cells with aggressive phenotypes. Reviewed

Shirakihara T, Kawasaki T, Fukagawa A, Semba K, Sakai R, Miyazono K, Miyazawa K, Saitoh M.

Cancer Sci.   104 ( 9 )   1189 - 1197   2013.9

Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β Reviewed

Motizuki M, Isogaya K, Miyake K, Ikushima H, Kubota T, Miyazono K, Saitoh M, Miyazawa K.

JOURNAL OF BIOLOGICAL CHEMISTRY   288 ( 26 )   18911 - 18922   2013.6( ISSN：0021-9258 )

Basolateral BMP signaling in polarized epithelial cells. Reviewed

Saitoh M, Shirakihara T, Fukasawa A, Horiguchi K, Sakamoto K, Sugiya H, Beppu H, Fujita Y, Morita I, Miyazono K, Miyazawa K.

PLos One   8 ( 5 )   e6265   2013.5

Phosphoinositide 5-phosphatases: how do they affect tumorigenesis? Invited Reviewed

Miyazawa, K.

J. Biochem.   153 ( 1 )   1 - 3   2013.1

A negative regulator or just an unconcerned passerby: phosphoinositide 3-kinase signaling in IL-12 production. Invited Reviewed

Miyazawa, K.

J. Biochem.   152 ( 6 )   497 - 499   2012.12

TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP. Reviewed

Horiguchi, K.,Sakamoto, K.,Koinuma, D.,Semba, K.,Inoue, A.,Inoue, S.,Fujii, H.,Yamaguchi, A.,Miyazawa, K.,Miyazono K.,Saitoh, M.

Oncogene   31 ( 26 )   3190 - 3201   2012.6

Transcriptional and post-transcriptional regulation of TGF-β mediated epithelial-mesenchymal transition Reviewed

J. Biochem.   151 ( 6 )   563 - 571   2012.5

Phosphorylation in the activation loop as the finishing touch in c-Kit activation. Reviewed

J. Biochem.   151 ( 5 )   457 - 459   2012.5

Structure of dominant-negative helix-loop-helix transcriptional regulator HHM representing the autoinhibition state. Reviewed

Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi SI, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O.

EMBO J.   30 ( 4 )   783 - 795   2012.3

Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4. Reviewed

Ikushima, H.,Todo, T.,Ino, Y.,Takahashi, M.,Saito, N.,Miyazawa, K.,Miyazono, K.

J. Biol. Chem.   286 ( 48 )   41434 - 41441   2011.12

RB1CC1 positively regulates TGF-β signaling through modulation of Arkadia E3 ubiquitin ligase activity. Reviewed

Koinuma, D., Shinozaki, M.,Nagano, Y.,Ikushima, H.,Horiguchi, K.,Goto, K.,Chano, T.,Saitoh, M.,Imamura, T.,Miyazono, K.,Miyazawa, K.

J. Biol. Chem.   286   32502 - 32512   2011.9

Encountering unpredicted off-target effects of pharmacological inhibitors. Reviewed

J. Biochem.   150 ( 1 )   1 - 3   2011.7

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1. Reviewed

J. Biol. Chem.   286 ( 8 )   6311 - 6320   2011.2

TGF-β regulates FGF receptor isoform switching and epithelial-mesenchymal transition. Reviewed

Shirakihara, T.,Horiguchi, K.,Miyazawa, K.,Ehata, S.,Shibata, T.,Morita, I.,Miyazono, K.,Saitoh, M.

EMBO JOURNAL   30   783 - 795   2011.2( ISSN：0261-4189 )

Dissecting the signal transduction pathway that directs endothelial differentiation using embryonic stem cell-derived vascular progenitor cells.

Kawasaki K, and Miyazawa K.

Embryonic Stem Cells -- Differentiation and Pluripotent Alternatives (ed. by Michael S. Kallos)   245 - 266   2011

Arkadia complexes with clathrin adaptor AP2 and regulates EGF signaling. Reviewed

J. Biochem.   148 ( 6 )   733 - 741   2010.12

Smad 7 inhibits transforming growth factor-β family type I receptors through two distinct modes of interaction. Reviewed

J. Biol. Chem.   285 ( 40 )   30804 - 30813   2010.10

Identification of a phosphorylation site in c-Ski as serine 515. Reviewed

J. Biochem.   148 ( 4 )   423 - 427   2010.10

Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. Reviewed

FEBS J.   277 ( 10 )   2208 - 2214   2010.5

Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells. Reviewed

JOURNAL OF BIOCHEMISTRY   147 ( 4 )   545 - 554   2010.4( ISSN：0021-924X )

Autocrine TGF-β signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Reviewed

Ikushima H, Todo T, Ino T, Takahashi T, Miyazawa K, Miyazono K.

Cell Stem Cell   5   504 - 514   2009.11

Functional in vivo optical imaging of tumor angiogenesis, growth and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells. Reviewed

Cancer Sci.   100 ( 11 )   2085 - 2092   2009.11

VEGFR2-PLCγ1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells. Reviewed

Sase H, Watabe T, Kawasaki K, Miyazono K, Miyazawa K.

J. Cell Sci.   122   3303 - 3311   2009.9

Pin1 binds to Smad2/3 and induces Smurf2-mediated degradation of Smad2/3 to down-regulate TGF-β signaling. Reviewed

J. Biol. Chem.   284   6109 - 6115   2009.3

The E3 ubiquitin-ligase WWP1 selectively targets HER4 and its proteolytic-derived signaling isoforms for degradation. Reviewed

Mol. Cell. Biol.   29 ( 3 )   892 - 906   2009.2

SKI and MEL1 cooperate to inhibit transforming growth factor-β signal in gastric cancer cells. Reviewed

J. Biol. Chem.   284   3334 - 3344   2009.1

Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling Reviewed

Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, Sunamura M, Imamura T, Miyazono K, Aburatani H.

Mol. Cell. Biol.   29 ( 1 )   172 - 186   2009.1

Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator. Reviewed

Seto A, Ikushima H, Suzuki T, Sato Y, Fukai S, Yuki K, Miyazawa K, Miyazono K, Ishitani R, Nureki O.

Acta Crystal.   F65   21 - 24   2009.1

Arkadia represses myoblast differentiation through degradation of Ski and the Ski-bound Smad complex. Reviewed

Bone   44   53 - 60   2009.1

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. Reviewed

J. Biol. Chem.   283   35660 - 35667   2008.12

An Id-like molecule, HHM, is a syn-expression group-restricted regulator of TGF-β signalling. Reviewed

Ikushima H, Komuro A, Isogaya K, Shinozaki M, Hellman U, Miyazawa K, Miyazono K.

EMBO J.   27   2955 - 2965   2008.11

Specificity of inhibitory effects of Dad on TGF-β family type I receptors in Drosophila. Reviewed

Kamiya Y, Miyazono K, Miyazawa K.

FEBS Lett.   582   2496 - 2500   2008.7

Activation of MET receptor tyrosine kinase in ulcer surface epithelial cells undergoing restitution. Reviewed

Nagai M, Takahashi N, Miyazawa K, Kawaguchi M, Chijiiwa K, Kataoka H.

Pathol. Int.   58   462 - 464   2008.7

SUMO amplifies TGF-beta signalling. Reviewed

Miyazono K, Kamiya Y, Miyazawa

Nat Cell Biol   10 ( 6 )   635 - 637   2008.6

Ras signaling specifies endothelial differentiation of VEGFR2+ vascular progenitor cells. Reviewed

J. Cell Biol.   181   131 - 141   2008.4

Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCFFWD1/β-TrCP-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1. Reviewed

Genes Cells   13   329 - 342   2008.4

Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines. Reviewed

Nakamura Y, Matsubara D, Goto A, Ota S, Sachiko O, Ishikawa S, Aburatani H, Miyazawa K, Fukayama M, Niki T.

Cancer Sci.   99 ( 1 )   14 - 22   2008.1

Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. Reviewed

Ehata S, Hanyu A, Hayashi M, Aburatani H, Kato Y, Fujime M, Saitoh M, Miyazawa K, Imamura T, Miyazono K.

Cancer Res.   67 ( 20 )   9694 - 9703   2007.10

Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors. Reviewed

Goto K, Kamiya Y, Imamura T, Miyazono K, Miyazawa K.

J Biol Chem.   282 ( 28 )   20603 - 20611   2007.7

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling. Reviewed

Nagano Y, Mavrakis KJ, Lee KL, Fujii T, Koinuma D, Sase H, Yuki K, Isogaya K, Saitoh M, Imamura T, Episkopou V, Miyazono K, Miyazawa K.

J Biol Chem.   282 ( 28 )   20492 - 20501   2007.7

c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis. Reviewed

Nakamura Y, Niki T, Goto A, Morikawa T, Miyazawa K, Nakajima J, Fukayama M.

Cancer Sci.   98 ( 7 )   1006 - 1013   2007.7

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases. Reviewed

Kobayashi N, Goto K, Horiguchi K, Nagata M, Kawata M, Miyazawa K, Saitoh M, Miyazono K.

Genes Cells   12 ( 3 )   375 - 385   2007.3

Inhibitory effect of c-Met mutants on the formation of branching tubules by a porcine aortic endothelial cell line. Reviewed

Maemura M, Yoshimoto A, Tsukada Y, Morishita Y, Miyazawa K, Tanaka T, Kitamura N.

Cancer Sci.   97 ( 12 )   1343 - 1350   2006.12

Nuclear and cytoplasmic c-Ski differently modulate cellular functions. Reviewed

Nagata M, Goto K, Ehata S, Kobayashi N, Saitoh M, Miyoshi H, Imamura T, Miyazawa K, Miyazono K.

Genes Cells.   11 ( 11 )   1267 - 1280   2006.11

VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling. Reviewed

Kano MR, Morishita Y, Iwata C, Iwasaka S, Watabe T, Ouchi Y, Miyazono K, Miyazawa K.

J Cell Sci.   118 ( 16 )   3759 - 3768   2005.8

Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta. Reviewed

Tanaka H, Nagaike K, Takeda N, Itoh H, Kohama K, Fukushima T, Miyata S, Uchiyama S, Uchinokura S, Shimomura T, Miyazawa K, Kitamura N, Yamada G, Kataoka H.

Mol Cell Biol.   25 ( 13 )   5687 - 5698   2005.7

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. Reviewed

Kuratomi G, Komuro A, Goto K, Shinozaki M, Miyazawa K, Miyazono K, Imamura T.

Biochem J   386 ( 3 )   461 - 470   2005.3

Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells. Reviewed

Suzuki H, Watabe T, Kato M, Miyazawa K, Miyazono K.

Blood   105 ( 6 )   2372 - 2379   2005.3

The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1. Reviewed

Hayakawa M, Kitagawa H, Miyazawa K, Kitagawa M, Kikugawa K.

Genes Cells   10 ( 3 )   241 - 251   2005.3

Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice. Reviewed

Itoh H, Naganuma S, Takeda N, Miyata S, Uchinokura S, Fukushima T, Uchiyama S, Tanaka H, Nagaike K, Shimomura T, Miyazawa K, Yamada G, Kitamura N, Koono M, Kataoka H.

Gastroenterology   127 ( 5 )   1423 - 1435   2004.11

Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2. Reviewed

Tsukada Y, Tanaka T, Miyazawa K, Kitamura N.

J Biochem   136 ( 5 )   701 - 709   2004.11

Activation of c-Met (hepatocyte growth factor receptor) in human gastric cancer tissue. Reviewed

Inoue T, Kataoka H, Goto K, Nagaike K, Igami K, Naka D, Kitamura N, Miyazawa K.

Cancer Sci.   95 ( 10 )   803 - 808   2004.10

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K, Miyazawa K.

Oncogene   23 ( 41 )   6914 - 6923   2004.9

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements. Reviewed

Suzuki H, Yagi K, Kondo M, Kato M, Miyazono K, Miyazawa K.

Oncogene   23 ( 29 )   5068 - 5076   2004.6

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. Reviewed

Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H, Fujita T, Imamura T, Miyazono K, Miyazawa K.

Mol Biol Cell   15 ( 3 )   963 - 972   2004.3

Activation of hepatocyte growth factor in monkey stomach following gastric mucosal injury. Reviewed

Hori T, Ido A, Uto H, Hasuike S, Moriuchi A, Hayashi K, Nakagawa S, Miyazawa K, Kitamura N, Tsubouchi H.

J Gastroenterol   39 ( 2 )   133 - 139   2004

TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. Reviewed

Watabe T, Nishihara A, Mishima K, Yamashita J, Shimizu K, Miyazawa K, Nishikawa S, Miyazono K.

J Cell Biol   163 ( 6 )   1303 - 1311   2003.12

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. Reviewed

Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K.

EMBO J   22 ( 24 )   6458 - 6470   2003.12

Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain. Reviewed

Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N.

J Biol Chem   278 ( 48 )   48162 - 48168   2003.11

SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.

Matsuyama S, Iwadate M, Kondo M, Saitoh M, Hanyu A, Shimizu K, Aburatani H, Mishima HK, Imamura T, Miyazono K, Miyazawa K. SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.

Cancer Res   63 ( 22 )   7791 - 7798   2003.11

A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. Reviewed

Inomata H, Nakamura Y, Hayakawa A, Takata H, Suzuki T, Miyazawa K, Kitamura N.

J Biol Chem   278 ( 25 )   22946 - 22955   2003.6

Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN. Reviewed

Mizuide M, Hara T, Furuya T, Takeda M, Kusanagi K, Inada Y, Mori M, Imamura T, Miyazawa K, Miyazono K.

J Biol Chem   278 ( 1 )   531 - 536   2003.1

Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells. Reviewed

Ota T, Fujii M, Sugizaki T, Ishii M, Miyazawa K, Aburatani H, Miyazono K.

J Cell Physiol   193 ( 3 )   299 - 318   2002.12

Two major Smad pathways in TGF-beta superfamily signalling. Reviewed

Miyazawa K, Shinozaki M, Hara T, Furuya T, Miyazono K.

Genes Cells   7 ( 12 )   1191 - 1204   2002.12

Id: a target of BMP signaling. Reviewed

Miyazono K, Miyazawa K.

Sci STKE   151   PE40   2002.9

Impairment of activation of hepatocyte growth factor precursor into its mature form in rats with liver cirrhosis. Reviewed

Kaibori M, Inoue T, Sakakura Y, Oda M, Nagahama T, Kwon AH, Kamiyama Y, Miyazawa K, Okumura T.

J Surg Res   106 ( 1 )   108 - 114   2002.7

Denda K, Shimomura T, Kawaguchi T, Miyazawa K, Kitamura N. Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1. Reviewed

Denda K, Shimomura T, Kawaguchi T, Miyazawa K, Kitamura N.

J Biol Chem   277 ( 16 )   14053 - 14059   2002.4

Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF. Reviewed

Kaibori M, Inoue T, Oda M, Naka D, Kawaguchi T, Kitamura N, Miyazawa K, Kwon AH, Kamiyama Y, Okumura T.

Biochem Biophys Res Commun   290 ( 1 )   475 - 481   2002.1

High intensity ERK signal mediates hepatocyte growth factor-induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2. Reviewed

Tsukada Y, Miyazawa K, Kitamura N.

J Biol Chem   276 ( 44 )   40968 - 40976   2001.11

Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. Reviewed

Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M.

Biochem Biophys Res Commun   288 ( 2 )   390 - 399   2001.10

Regulation of hepatocyte growth factor (HGF) activation on cell surface: Insights into an emerging class of cell surface protease inhibitors. Reviewed

Kataoka H, Itoh H, Shimomura T, Nuki Y, Naganuma S, Miyazawa K.

Int Arch Biosci   1036 - 1042   2001

Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. Reviewed

Kataoka H, Shimomura T, Kawaguchi T, Hamasuna R, Itoh H, Kitamura N, Miyazawa K, Koono M.

J Biol Chem   275 ( 51 )   40453 - 40462   2000.12

A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. Reviewed

Kato M, Miyazawa K, Kitamura N.

J Biol Chem   275 ( 48 )   37481 - 37487   2000.12

Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract. Reviewed

Itoh H, Hamasuna R, Kataoka H, Yamauchi M, Miyazawa K, Kitamura N, Koono M.

Biochim Biophys Acta   1491 ( 1-3 )   295 - 302   2000.4

Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency. Reviewed

Leppanen O, Miyazawa K, Backstrom G, Pietras K, Sjoblom T, Heldin CH, Ostman A.

Biochemistry   39 ( 9 )   2370 - 2375   2000.3

Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form. Reviewed

Shimomura T, Denda K, Kawaguchi T, Matsumoto K, Miyazawa K, Kitamura N.

J Biochem   126 ( 5 )   821 - 828   1999.11

Molecular cloning and characterization of a novel protein serine/threonine kinase highly expressed in mouse embryo. Reviewed

Kurioka K, Nakagawa K, Denda K, Miyazawa K, Kitamura N.

Biochim Biophys Acta   1443 ( 3 )   275 - 284   1998.12

Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator. Reviewed

Miyazawa K, Wang Y, Minoshima S, Shimizu N, Kitamura N.

Eur J Biochem   258 ( 2 )   335 - 361   1998.12

Role of immunoglobulin-like domains 2-4 of the platelet-derived growth factor alpha-receptor in ligand-receptor complex assembly. Reviewed

Miyazawa K, Backstrom G, Leppanen O, Persson C, Wernstedt C, Hellman U, Heldin CH, Ostman A.

J Biol Chem   273 ( 39 )   25495 - 25502   1998.9

Identification of a 190-kDa vascular endothelial growth factor 165 cell surface binding protein on a human glioma cell line. Reviewed

Omura T, Miyazawa K, Ostman A, Heldin CH.

J Biol Chem   272 ( 37 )   23317 - 23322   1997.9

Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. Reviewed

Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N.

J Biol Chem   272 ( 10 )   6370 - 6376   1997.3

Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation. Reviewed

Okajima A, Miyazawa K, Naitoh Y, Inoue K, Kitamura N.

Hepatology   25 ( 1 )   97 - 102   1997.1

Production and activation of hepatocyte growth factor during the healing of rat gastric ulcers. Reviewed

Kinoshita Y, Kishi K, Asahara M, Matasushima Y, Wang HY, Miyazawa K, Kitamura N, Chiba T.

Digestion   58 ( 3 )   225 - 231   1997

Purification and characterization of a novel protease inhibitor specific to hepatocyte growth factor activator.

Kawaguchi T, Shimomura T, Denda K, Kitamura A, Kondo J, Kito M, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N.

Animal Cell Technology: Basic & Applied Aspects   8   403 - 407   1997

Hepatocyte growth factor (HGF)-induced cell migration is negatively modulated by epidermal growth factor through tyrosine phosphorylation of the HGF receptor. Reviewed

Takeuchi K, Shibamoto S, Hayakawa M, Hori T, Miyazawa K, Kitamura N, Ito F.

Exp Cell Res   223 ( 2 )   420 - 425   1996.3

Dissociation of c-fos induction and mitogen-activated-protein kinase activation from the hepatocyte-growth-factor-induced motility response in human gastric carcinoma cells. Reviewed

Nagamine K, Shibamoto S, Takeuchi K, Miyazawa K, Kitamura N, Chatani Y, Kohno M, Ito F.

Eur J Biochem   236 ( 2 )   476 - 481   1996.3

Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. Reviewed

Miyazawa K, Shimomura T, Kitamura N.

J Biol Chem   271 ( 7 )   3615 - 3618   1996.2

Hepatocyte growth factor remains as an inactive single chain after partial hepatectomy or unilateral nephrectomy. Reviewed

Tang W, Miyazawa K, Kitamura N.

FEBS Lett   362 ( 2 )   220 - 224   1995.4

Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator.

Shimomura T, Miyazawa K, Komiyama Y, Hiraoka H, Naka D, Morimoto Y, Kitamura N.

Eur J Biochem   229 ( 1 )   257 - 261   1995.4

Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. Reviewed

Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M, Ito F.

J Cell Biol   128 ( 5 )   949 - 957   1995.3

Proteolytic activation of hepatocyte growth factor in response to tissue injury. Reviewed

Miyazawa K, Shimomura T, Naka D, Kitamura N.

J Biol Chem   269 ( 12 )   8966 - 8970   1994.3

Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Reviewed

Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Oku N, Miyazawa K, Kitamura N, Takeichi M, Ito F.

Cell Adhes Commun   1 ( 4 )   295 - 305   1994.1

Stimulation of prostaglandin production by hepatocyte growth factor in human gastric carcinoma cells. Reviewed

Hori T, Shibamoto S, Hayakawa M, Takeuchi K, Oku N, Miyazawa K, Kitamura N, Ito F.

FEBS Lett   334 ( 3 )   331 - 334   1993.11

Activation of the zymogen of hepatocyte growth factor activator by thrombin. Reviewed

Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N.

J Biol Chem   268 ( 30 )   22927 - 22932   1993.10

Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. Reviewed

Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N.

J Biol Chem   268 ( 30 )   22927 - 22932   1993.5

Characterization of the promoter region of the rat hepatocyte-growth-factor/scatter-factor gene. Reviewed

Okajima A, Miyazawa K, Kitamura N.

Eur J Biochem   213 ( 1 )   113 - 119   1993.4

Gene expression and regulation of HGF-SF. Reviewed

Kitamura N, Miyazawa K, Uehara Y, Komada M, Okajima A, Okigaki M, Kitamura A.

Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the c-Met Receptor. (ed. by Goldberg and Rosen)   49 - 65   1993

Functional characterization of human hepatocyte growth factor mutants obtained by deletion of structural domains. Reviewed

Okigaki M, Komada M, Uehara Y, Miyazawa K, Kitamura N.

Biochemistry   31 ( 40 )   9555 - 9561   1992.10

Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. Reviewed

Naka D, Ishii T, Yoshiyama Y, Miyazawa K, Hara H, Hishida T, Kitamura N.

J Biol Chem   267 ( 28 )   20114 - 20119   1992.10

Hepatocyte growth factor and transforming growth factor-beta stimulate both cell growth and migration of human gastric adenocarcinoma cells. Reviewed

Shibamoto S, Hayakawa M, Hori T, Oku N, Miyazawa K, Kitamura N, Ito F.

Cell Struct Funct   17 ( 3 )   185 - 190   1992.6

Characterization of hepatocyte-growth-factor receptors on Meth A cells. Reviewed

Komada M, Miyazawa K, Ishii T, Kitamura N.

Eur J Biochem   204 ( 2 )   857 - 864   1992.3

Hepatocyte growth factor in blood and liver in mice treated with hepatotoxins

Gohda E, Hayashi Y, Miyazawa K, Kitamura N, Yamamoto I.

Frontiers of mucosal immunology   1   101 - 104   1992

Structural organization and the transcription initiation site of the human hepatocyte growth factor gene.

Miyazawa K, Kitamura A, Kitamura N.

Biochemistry   30 ( 38 )   9170 - 9176   1991.9

An alternatively processed mRNA generated from human hepatocyte growth factor gene. Reviewed

Miyazawa K, Kitamura A, Naka D, Kitamura N.

Eur J Biochem   197 ( 1 )   15 - 22   1991.4

Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury. Reviewed

Okajima A, Miyazawa K, Kitamura N.

Eur J Biochem   193 ( 2 )   375 - 381   1990.10

Complement activation induced by human C-reactive protein in mildly acidic conditions. Reviewed

Miyazawa K, Inoue K.

J Immunol   145 ( 2 )   15 - 22   1990.7

Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Reviewed

Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K, Goda E, Daikuhara Y, Kitamura N.

Biochem Biophys Res Commun   163 ( 2 )   967 - 973   1989.9

Modulation of stimulus-dependent human platelet activation by C-reactive protein modified with active oxygen species. Reviewed

Miyazawa K, Kiyono S, Inoue K.

J Immunol   141 ( 2 )   570 - 574   1988.7

進化するがん創薬

（清宮啓之　編）（ Role： Contributor第１章　）

化学同人  2019.6 

人体の細胞生物学

（坂井、石崎　編）（ Role： Contributor3-4, 4-2）

日本医事新報社  2018.11  （  ISBN:978-4-7849-3232-0 ）

臨床生化学（第５版）

（宮澤　編）（宮澤, 根本, 齋藤, 望月　執筆）（ Role： Editor１章、７章）

メディカ出版  2018.1 

デヴィータ　がんの分子生物学　第２版

（宮園・石川・間野　編）（ Role： Joint Translation 第2章）

メディカル　サイエンス　インターナショナル  2017.5 

サイトカイン・増殖因子　キーワード事典

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2015.4 

カラー生化学　第４版

（石浦、板部、高木、中谷、水島、横溝　監訳）（ Role： Joint Translation 第11章）

西村書店  2015.3 

からだのなぜ？がわかる　生化学・生理学　超基本

岩田英里子　著,宮澤恵二　監修（ Role： Supervisor-）

メディカ出版  2013.11 

TGF-β in human disease

（ Role： Joint Editor）

Springer Japan  2013.7 

デヴィータ　がんの分子生物学

（宮園・石川・間野　編）（ Role： Joint Translation 第５章）

メディカル・サイエンス・インターナショナル  2012.9 

がんの増殖と悪性化の分子機構

（宮澤・伊東　編）（ Role： Joint Editor-）

化学同人  2012.9 

TGF-βシグナル研究---メカニズムの解明から新たな治療へ

（編集　宮園浩平・宮澤恵二）（ Role： Joint Editor）

医歯薬出版株式会社  2010.9 

細胞の個性に応じて機能するTGF-βファミリー

企画：宮澤恵二, 伊東進（ Role： Joint Editor）

羊土社  2010.3 

分子細胞生物学辞典（第２版）

（-）

東京化学同人  2008.10 

タンパク質の事典

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廣川書店  2008.7 

細胞生物学概論

2017Year  Type of subject：Dr. (Graduate School)

生化学B

2017Year  Type of subject：Professional education (undergraduate)