Updated on 2025/05/01

写真a

 
Yasunori Mori
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine (Biochemistry 1) Associate Professor
Title
Associate Professor

Research History

  • University of Yamanashi   Associate Professor

    2021.4

  • 同志社大学大学院脳科学研究科   神経膜分子機能部門   特任准教授

    2014.4 - 2021.3

  • Doshisha University, Graduate School of Brain Science   Laboratory of Neural Membrane Biology   Research associate professor

    2014.4 - 2021.3

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    Country:Japan

    Job classification:Associate professor/Lecturer (full time)

  • ブリストル大学   MRCシナプス可塑性センター   滞在研究員

    2013.4 - 2014.3

  • University of Bristol   School of Biochemistry, MRC Centre for Synaptic Plasticity   Research fellow

    2013.4 - 2014.3

  • 東北大学大学院生命科学研究科   膜輸送機構解析分野   特任助教

    2009.4 - 2013.3

  • Graduate School of Life Sciences, Tohoku University   Laboratory of Membrane Trafficking Mechanisms   Assistant Professor

    2009.4 - 2013.3

  • 東北大学大学院生命科学研究科   膜輸送機構解析分野   助手

    2008.9 - 2009.3

  • Graduate School of Life Sciences, Tohoku University   Laboratory of Membrane Trafficking Mechanisms   Assistant

    2008.9 - 2009.3

  • 理化学研究所   袖岡有機合成化学研究室   協力研究員

    2005.10 - 2008.8

  • RIKEN   Synthetic Organic Chemistry Laboratory   Post-Doctorate

    2005.10 - 2008.8

  • 東京大学 分子細胞生物学研究所   情報伝達研究分野    博士研究員

    2005.4 - 2005.9

  • Institute of Molecular and Cellular Biosciences, University of Tokyo   Post-Doctorate

    2005.4 - 2005.9

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Education

  • The University of Tokyo

    2001.4 - 2005.3

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    Country: Japan

    Course: Doctor course

  • Graduate School of Frontier Science, The University of Tokyo   Department of Integrated Biosciences, PhD course

    2001.4 - 2005.3

  • The University of Tokyo

    1999.4 - 2001.3

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    Country: Japan

    Course: Master course

  • Graduate School of Frontier Science, The University of Tokyo   Department of Integrated Biosciences, master course

    1999.4 - 2001.3

  • Tokyo Gakugei University

    1995.4 - 1999.3

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    Country: Japan

  • Tokyo Gakugei University   Faculty of Education

    1995.4 - 1999.3

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Degree

  • 博士(生命科学) ( 東京大学 )

  • 修士(生命科学) ( 東京大学 )

Research Areas

  • Life Science / Cell biology

  • Life Science / Neuroscience-general

  • Life Science / Cell biology

  • Life Science / Neuroscience-general  / 分子・細胞神経科学

  • Life Science / Molecular biology

Research Interests

  • ライブイメージング

  • 小胞輸送

  • Membrane Trafficking

  • 細胞生物学

  • 神経科学

  • Dendrite

  • 極性輸送

  • dense-core vesicle

  • 小胞輸送

  • 包括脳ネットワーク

  • presynapse

  • フィロポディア

  • スパイン

  • Synaptotagmin

  • シナプス形成

  • synaptic vesicle

  • シグナル伝達

  • endosome

  • live imaging

  • Syntaxin

  • Synapse

  • SNARE

  • Signal transduction

  • Rab

  • Neuron

  • MAP kinase

  • JNK

  • Hippocampal neuron

  • GEF

Research Projects

  • Grant-in-Aid for Scientific Research(C)

    2018.4 - 2021.3

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    Authorship:Principal investigator  Grant type:Competitive 

  • 神経細胞の軸索終末においてエンドソームに由来する小胞の役割

    2018 - 2021

  • グルタミン酸受容体の輸送機構の解明

    2013.4 - 2014.3

    上原記念生命科学財団  平成24年度 海外留学助成リサーチフェローシップ 

    森靖典

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    Authorship:Principal investigator  Grant type:Competitive 

  • 樹状突起特異的な小胞輸送に関与するRab17タンパク質の解析

    2012

  • Grant-in-Aid for Young Scientists (B)

    Grant number:24700308  2012

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    Authorship:Principal investigator  Grant type:Competitive 

  • 樹状突起特異的な小胞輸送に関与するRabタンパク質の解析

    2010 - 2011

  • Grant-in-Aid for Young Scientists (B)

    Grant number:22700324  2010 - 2011

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    Authorship:Principal investigator  Grant type:Competitive 

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Papers

  • Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses Reviewed

    Tania López-Hernández, Koh-ichiro Takenaka, Yasunori Mori, Pornparn Kongpracha, Shushi Nagamori, Volker Haucke Is a corresponding author, Shigeo Takamori Is a corresponding author

    eLife   11   e71198   2022.1( ISSN:2050-084X  eISSN:2050-084X )

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:eLife Sciences Publications, Ltd  

    Neurotransmission is based on the exocytic fusion of synaptic vesicles (SVs) followed by endocytic membrane retrieval and the reformation of SVs. Conflicting models have been proposed regarding the mechanisms of SV endocytosis, most notably clathrin/adaptor protein complex 2 (AP-2)-mediated endocytosis and clathrin-independent ultrafast endocytosis. Partitioning between these pathways has been suggested to be controlled by temperature and stimulus paradigm. We report on the comprehensive survey of six major SV proteins to show that SV endocytosis in mouse hippocampal neurons at physiological temperature occurs independent of clathrin while the endocytic retrieval of a subset of SV proteins including the vesicular transporters for glutamate and GABA depend on sorting by the clathrin adaptor AP-2. Our findings highlight a clathrin-independent role of the clathrin adaptor AP-2 in the endocytic retrieval of select SV cargos from the presynaptic cell surface and suggest a revised model for the endocytosis of SV membranes at mammalian central synapses.

    DOI: 10.7554/eLife.71198

    PubMed

    Other Link: https://cdn.elifesciences.org/articles/71198/elife-71198-v1.xml

  • The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons Reviewed Major achievement

    Yasunori Mori, Koh-ichiro Takenaka, Yugo Fukazawa & Shigeo Takamori

    Communications Biology   4   981   2021.8( ISSN:2399-3642 )

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

Presentations

  • Active zone protein CAST and ELKS are defined total recycling pool size at cultured hippocampal neurons. International conference

    Yasunori Mori, Fumihiro Kaku, Toshihisa Ohtsuka

    Neuro2024, Fukuoka, Japan  2024.7 

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    Event date: 2024.7

    Language:English   Presentation type:Poster presentation  

  • The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons International conference

    Yasunori Mori

    The third international symposium on brain science: University of Yamanashi  2022.3 

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    Event date: 2022.3

    Language:English   Presentation type:Symposium workshop panel(nominated)  

    Venue:Kofu. Yamanashi, Japan  

  • Q-SNARE Syntaxin-7 defines a reluctant recycling pool of synaptic vesicles in hippocampal neurons

    Yasunori Mori, Koichiro Takenaka, Yugo Fukazawa, Shigeo Takamori

    The 42nd Annual Meeting of the Molecular Biology Society of Japan (Fukuoka)  2019.12 

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    Language:Japanese   Presentation type:Poster presentation  

  • Q-SNARE Syntaxin 7 defines a reluctant recycling pool of synaptic vesicles in hippocampal neurons

    森靖典, 竹中康一郎, 深澤有吾, 高森茂雄

    生理学研究所シナプス研究会「ミクロからマクロに至る脳の構造と機能のダイナミクス」(口頭発表)  2019.11 

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    Language:Japanese   Presentation type:Oral presentation(general)  

  • Expression of plasma membrane calcium ATPases confers Ca2+/H+ exchange in rodent synaptic vesicles International conference

    Yoshiyasu Ono, Yasunori Mori, Yoshihiro Egashira, Kenta Sumiyama, Shigeo Takamori

    JSPS Core-to-Core Symposium “Nanobiology of neural plasticity based on optical nanoscopy” (Imadegawa, Kyoto)(ポスター)  2018.12 

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    Language:English   Presentation type:Poster presentation  

  • Q-SNARE Syntaxin 7 defines a reluctant recycling pool of synaptic vesicles in hippocampal neurons International conference

    Yasunori Mori, Koichiro Takenaka, Yugo Fukazawa, Shigeo Takamori

    JSPS Core-to-Core Symposium “Nanobiology of neural plasticity based on optical nanoscopy” (Imadegawa, Kyoto)(ポスター)  2018.12 

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    Language:English   Presentation type:Poster presentation  

  • Development of lentiviral vectors for efficient glutamatergic-selective gene transduction in cultured hippocamal neurons International conference

    Yoshihiro Egashira, Yasunori Mori, Yuchio Yanagawa, Shigeo Takamori

    The 41st Annual Meeting of the Japan Neuroscience Society, Kobe, Japan  2018.7 

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    Language:English   Presentation type:Poster presentation  

  • Endosomal Q-SNARE Syntaxin 7 specifies a subpopulation of recycling synaptic vesicles preferentially responsive to high frequency stimulation. International conference

    Yasunori Mori, Yugo Fukazawa, Shigeo Takamori

    Joint annual meeting of 51st JSDB and 70th JSCB. Tower hall Funabori, Tokyo  2018.6 

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    Language:English   Presentation type:Oral presentation(general)  

  • Component of endosomal SNAREs distinguishes synaptic vesicle property in hippocampal neurons

    Yasunori Mori

    ConBio2017  2017.12 

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    Language:Japanese   Presentation type:Symposium workshop panel(nominated)  

  • Expression of plasma membrane calcium ATPases confers Ca2+/H+exchange in rodent synaptic vesicles. International conference

    Yoshiyasu Ono, Kenta Sumiyama, Yasunori Mori, Yoshihiro Egashira, Shigeo Takamori

    JSPS Core-to-Core Symposium “Nanobiology of neural plasticity based on optical nanoscopy” Doshisha Biwako Retreat Center, Otsu  2017.11 

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    Language:English   Presentation type:Poster presentation  

  • Q-SNARE Syntaxin 7 specifies rapidly replenishing synaptic vesicles during high activity. International conference

    Yasunori Mori, Shigeo Takamori

    JSPS Core-to-Core Symposium “Nanobiology of neural plasticity based on optical nanoscopy” Doshisha Biwako Retreat Center, Otsu  2017.11 

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    Language:English   Presentation type:Oral presentation(general)  

  • Role of endosomal pathway in synaptic vesicle recycling. International conference

    Yasunori Mori, Shigeo Takamori

    JSPS Core-to-Core Symposium “Nanophysiology of synapses in the central nervous system” Okinawa Institute of Science and Technology, Onna-son, Okinawa  2016.9 

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    Language:English   Presentation type:Poster presentation  

  • Endosomal t-SNARE Syntaxin-12/13 preferentially promotes spontaneous release in hippocampal neurons. International conference

    Yasunori Mori, Shigeo Takamori

    JSPS Core-to-Core Symposium “Mechanisms of synaptic transmission” Université Paris Descartes, Paris, France  2015.9 

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    Language:English   Presentation type:Poster presentation  

  • Small GTPase Rab17 and its guanine nucleotide exchange factor Rabex-5 regulate the dendritic morphogenesis of hippocampal neurons International conference

    Yasunori Mori, Takahide Matsui, Mitsunori Fukuda

    YLS2013: Molecular Mechanisms of Membrane Dynamics, Bristol, UK  2013.9 

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    Language:English   Presentation type:Oral presentation(general)  

  • 樹状突起特異的な小胞輸送に関与する低分子量Gタンパク質Rab17の解析

    森靖典, 松井貴英, 古谷裕, 吉原良浩, 福田光則

    第3回新学術領域研究「包括型脳科学研究推進支援ネットワーク」夏のワークショップ(ポスター)  2012.7 

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    Language:Japanese   Presentation type:Poster presentation  

  • Small GTPase Rab17 regulates the dendritic morphogenesis and postsynaptic development of hippocampal neurons.

    森靖典, 松井貴英, 古谷裕, 吉原良浩, 福田光則

    第4回新学術領域研究「細胞内ロジスティクス」班会議(秋保)(ポスター)  2012.6 

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    Language:Japanese   Presentation type:Poster presentation  

  • Small GTPase Rab17 regulates the dendritic morphogenesis and postsynaptic development of hippocampal neurons. International conference

    Joint Spring Conference of BSCB / BSDB / JSDB, at the University of Warwick, Coventry, UK  2012.4 

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    Language:English   Presentation type:Poster presentation  

    Venue:Coventry, UK  

  • Rab17, a dendrite-specific Rab protein, regulates the dendritic morphogenesis and postsynaptic development of hippocampal neurons International conference

    森靖典, 松井貴英, 古谷裕, 吉原良浩, 福田光則

    第34回日本分子生物学会年会(横浜)(口頭発表)  2011.12 

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    Language:Japanese   Presentation type:Oral presentation(general)  

  • Rab17 regulates dendritic morphologenesis of hippocampal neurons

    森靖典, 松井貴英, 古谷裕, 吉原良浩, 福田光則

    第3回新学術領域研究「細胞内ロジスティクス」班会議(鳥羽)(ポスター)  2011.6 

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    Language:Japanese   Presentation type:Poster presentation  

  • JNK経路による開口放出制御の解析

    森靖典, 増山典久, 後藤由季子

    第26回日本神経科学大会(名古屋)(ポスター)  2003.7 

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    Language:Japanese   Presentation type:Poster presentation  

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Awards

  • 日本細胞生物学会論文賞

    2005.5  

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    Award type:Honored in official journal of a scientific society, scientific journal 

  • CSF Award

    2005.5  

    MORI Yasunori

Other

  • キナーゼによる分泌小胞開口放出制御機構の研究

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    2005年3月24日
    博士(生命科学)取得
    http://jairo.nii.ac.jp/0021/00000069/en

Teaching Experience (On-campus)

  • Biochemistry B

    2025Year

  • Pathology and Pharmacology

    2025Year

  • Life Science II (Basic Medical Sciences: Host Defense and Pathological Regulation)

    2025Year

  • Special lecture of medical neu roscience

    2025Year

  • Pathology and Pharmacology

    2024Year

  • Biochemistry A Major achievement

    2024Year

  • Biochemistry B Major achievement

    2024Year

  • Neuroscience

    2024Year

  • Life Science II (Basic Medical Sciences: Host Defense and Pathological Regulation)

    2024Year

  • Special lecture of medical neu roscience

    2024Year

  • Life Science II (Basic Medical Sciences: Host Defense and Pathological Regulation)

    2023Year

  • Special lecture of medical neu roscience

    2023Year

  • Neuroscience

    2023Year

  • Life Science II (Basic Medical Sciences: Host Defense and Pathological Regulation)

    2022Year  Type of subject:Master's (Graduate School)

  • Biochemistry A Major achievement

    2022Year  Type of subject:Common education (undergraduate)

  • Biochemistry B

    2022Year  Type of subject:Common education (undergraduate)

  • 病態生理論II

    2022Year  Type of subject:Common education (undergraduate)

  • Neuroscience

    2022Year  Type of subject:Common education (undergraduate)

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Other undergraduate student guidance

  • 2024

    Class teacher - period: 2021 - 2024

Professional Memberships

  • 日本細胞生物学会

    2014.4

  • 日本分子生物学会

    2010.6

  • 日本神経科学会

    2007.6