Updated on 2025/04/18

写真a

 
Kentaro TAKAGAKI
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine (Anatomy and System Biology) Senior Assistant Professor
Title
Senior Assistant Professor
Contact information
メールアドレス
External link

Research History

  • Tokyo Medical and Dental University   Institute of Global Affairs   Associate Professor   Major achievement

    2024.7

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    Job classification:Associate professor/Lecturer (full time)

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  • 徳島大学医学部   非常勤講師   Major achievement

    2024.4

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    Job classification:Lecturer (part-time)

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  • Tokyo Medical and Dental University   Institute of Global Affairs   Adjunct Faculty

    2024.4 - 2024.6

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  • University of Yamanashi   Faculty of Medicine, Department of Anatomy   Associate Professor (University)   Major achievement

    2023.5

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    Job classification:Associate professor/Lecturer (full time)

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  • University of Yamanashi   Faculty of Medicine, Department of Anatomy   Associate Professor / Lecturer

    2023.4

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    Job classification:Associate professor/Lecturer (full time)

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  • Hawaii Medical Education Program / JrSr   HMEP-NBME Asessments   Executive Chief Proctor   Major achievement

    2023

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    Job classification:Professor

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  • The University of Tokushima   Bio-Innnovation Research Center   Associate Professor, Special Appointment

    2021.4 - 2023.3

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    Job classification:Associate professor/Lecturer (full time)

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  • The University of Tokushima

    2020.2 - 2021.3

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    Job classification:Researcher/Postdoc

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  • Leibniz Institute for Neurobiology, Magdeburg   Systems Physiology of Learning   Guest Scientist   Major achievement

    2019.10 - 2024.9

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    Job classification:Assistant professor

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  • Otto von Guericke University, Magdeburg   Institute of Biology, Faculty of Natural Sciences   Senior Research Fellow

    2019.10 - 2021.3

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    Job classification:Assistant professor

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  • Leibniz Institute for Neurobiology, Magdeburg   Systems Physiology of Learning / Working Group Neurooptics   Group Leader   Major achievement

    2012.9 - 2019.9

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    Job classification:Associate professor/Lecturer (full time)

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  • Georgetown University Hospital   Department of Internal Medicine   Preliminary Intern   Major achievement

    2011.8 - 2012.8

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    Job classification:Doctor, nurse, lawyer, or other expert

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  • Leibniz Institut for Neurobiology, Magdeburg   Humboldt Foundation Fellow   Major achievement

    2010.9 - 2011.7

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    Job classification:Researcher/Postdoc

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Education

  • Georgetown University   School of Medicine   MD/PhD Program

    2002.8 - 2010.8

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    Country: United States

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  • Georgeown University   School of Medicine   Interdisciplinary Program in Neuroscience

    2002.8 - 2007.12

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    Country: United States

    Notes: PhD

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  • The University of Tokyo

    2002.4 - 2002.8

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    Country: Japan

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  • The University of Tokyo   College of Arts and Sciences

    1998.4 - 2002.3

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    Country: Japan

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  • Eiko Gakuen Jesuit Preparatory School

    1995.4 - 1998.3

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Degree

  • Doctor of Medicine ( 2011 )

  • PhD Neuroscience ( 2008 )

  • Bachelor of Agriculture (Bachelor of Science) ( 2002.3 )

Research Areas

  • Life Science / Laboratory animal science  / choirology, translational pig research  Major achievement

  • Life Science / Medical systems  / preclinical information management systems

  • Life Science / Animal physiological chemistry, physiology and behavioral biology  / neurophysiology, optical imaging, neurooptics, behavioral physiology, electroencephalography, multiparallel single-unit recording  Major achievement

  • Life Science / Animal life science  / pig, human, macroanatomy, neuroanatomy

  • Nanotechnology/Materials / Nanobioscience  / carbon nanotubes, minimally invasive intracranial electrodes, minimally invasive brain surface electrodes  Major achievement

Research Interests

  • Major achievement
    Electrode device development

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    Cognitive neurophysiology

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    Behavioral Physiology

  • Neurophysiology

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    Electroencephalography

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    Auditory physiology

  • Neurology

  • Major achievement
    Lesmology

  • Major achievement
    大動物実験医学プラットフォームの創設(産学連携研究)

  • Major achievement
    International Standardization of Japanese Medical Education

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    Lifespan Physiology

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    Multiparallel unit physiology

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    Choirology

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    Single-unit physiology

Papers

  • [The Current State of Experimental Medicine in Europe and Perspectives in Electroencephalography Research]

    Kentaroh Takagaki

    Obe-lisk   27 ( 1 )   22 - 26   2022.1

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

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  • An optically transparent multi-electrode array for combined electrophysiology and optophysiology at the mesoscopic scale. Reviewed

    Kentaroh Takagaki

    Journal of neural engineering   17 ( 4 )   046014   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    <h4>Objective</h4>A number of tissue penetrating opto-electrodes to simultaneously record and optogenetically influence brain activity have been developed. For experiments at the surface of the brain, such as electrocorticogram (ECoG) recordings and surface optogenetics, fewer devices have been described and no device has found widespread adoption for neuroscientific experiments. One issue slowing adoption is the complexity and fragility of existing devices, typically based on transparent electrode materials like graphene and indium-tin oxide (ITO). We focused here on improving existing processes based on metal traces and polyimide (PI), which produce more robust and cost-effective devices, to develop a multi-electrode array for optophysiology.<h4>Approach</h4>The most widely used substrate material for surface electrodes, PI, has seen little use for optophysiologicalμECoG/ECoG arrays. This is due to its lack of transparency at optogenetically relevant short wavelengths. Here we use very thin layers of PI in combination with chrome-gold-platinum electrodes to achieve the necessary substrate transparency and high mechanical flexibility in a device that still rejects light artifacts well.<h4>Main results</h4>The manufactured surface arrays have a thickness of only 6.5 µm, resulting in 80% transparency for blue light. We demonstrate immunity against opto-electric artifacts, long term stability and biocompatibility as well as suitability for optical voltage imaging. The biocompatible arrays are capable of recording stable ECoGs over months without any measurable degradation and can be used to map the tonotopic organization of the curved rodent auditory cortex.<h4>Significance</h4>Our novel probes combine proven materials and processing steps to create optically near-transparent electrode arrays with superior longevity. In contrast to previous opto-electrodes, our probes are simple to manufacture, robust, offer long-term stability, and are a practical engineering solution for optophysiological experiments not requiring transparency of the electrode sites themselves.

    DOI: 10.1088/1741-2552/aba1a4

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  • Author Correction: Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life Reviewed

    Gabriel Berdugo-Vega, Gonzalo Arias-Gil, Adrian López-Fernández, Benedetta Artegiani, Joanna M. Wasielewska, Chi-Chieh Lee, Michael T. Lippert, Gerd Kempermann, Kentaroh Takagaki, Federico Calegari

    Nature Communications   11 ( 1 )   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    DOI: 10.1038/s41467-020-14935-4

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  • Emergence of dominant initiation sites for interictal spikes in rat neocortex. Reviewed

    Kentaroh Takagaki

    Journal of neurophysiology   114 ( 6 )   3315 - 3325   2015.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    Neuronal populations with unbalanced inhibition can generate interictal spikes (ISs), where each IS starts from a small initiation site and then spreads activation across a larger area. We used in vivo voltage-sensitive dye imaging to map the initiation site of ISs in rat visual cortex disinhibited by epidural application of bicuculline methiodide. Immediately after the application of bicuculline, the IS initiation sites were widely distributed over the entire disinhibited area. After ∼ 10 min, a small number of sites became "dominant" and initiated the majority of the ISs throughout the course of imaging. Such domination also occurred in cortical slices, which lack long-range connections between the cortex and subcortical structures. This domination of IS initiation sites may allow timing-related plasticity mechanisms to provide a spatial organization where connections projecting outward from the dominant initiation site become strengthened. Understanding the spatiotemporal organization of IS initiation sites may contribute to our understanding of epileptogenesis in its very early stages, because a dominant IS initiation site with strengthened outward connectivity may ultimately develop into a seizure focus.

    DOI: 10.1152/jn.00471.2014

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  • Development of the posterior basic rhythm in children with autism Reviewed

    Kentaroh Takagaki

    Clinical Neurophysiology   126 ( 2 )   297 - 303   2015.2( ISSN:1388-2457 )

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.clinph.2014.04.022

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  • Compression and reflection of visually evoked cortical waves. Reviewed

    Huang X, Takagaki K, Wu JY, Xu W

    Neuron   55 ( 1 )   119 - 129   2007.7( ISSN:0896-6273 )

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.neuron.2007.06.016

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Presentations

  • Assessing Interest and Awareness Among Japanese Medical Students in International Standardized Testing: The Introduction of the National Board of Medical Examiners (NBME) Comprehensive Basic Science Examination (CBSE) in Japan

    Emi Saegusa-Beecroft, Kentaroh Takagaki, Junji B. Machi

    https://scholarspace.manoa.hawaii.edu/items/5b50c694-5519-408d-aac7-749e543f7e70  2024 

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    Language:English  

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  • Cortical spiral wave activity in Mongolian gerbils with epilepsy

    Takagaki K, Lippert MT, Wanger T, Ohl FW

    Society for Neuroscience  2012.11 

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    Language:English  

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  • Cortical Spiral Dynamics in a Gerbil Model of Epilepsy

    Takagaki K, Huang XY, Wu JY, Ohl FW

    10th Göttingen Meeting of the German Neuroscience Society  2011.3 

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    Language:English  

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Industrial Property Rights

  • 実験動物の管理システムおよび管理方法 Major achievement

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    Application no:特願2023-542153  Date applied:2023

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  • Basically Wire-Shaped Electrode for Transmittance of Electrophysiological Neurosignals and Method of Manufacture Thereof (Processes for the design, microfabrication, and use of individualized brain electrodes) Major achievement

    Kentaroh Takagaki, Rodrigo Herrera-Molina, Martin Ecke, Markus Wilke, Andre Weber, Zifeng Xia

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    Application no:EP22166952  Date applied:2021

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  • 生物輸送用システム Major achievement

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    Application no:特願2021-172267  Date applied:2021

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  • Object Carrier for Microscopy, Method of making Same and Method of Measuring Therewith (Functionalized imaging plate for non-invasive, combinatorial, and/or simultaneous electrical and optic stimulation and measurement) Major achievement

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    Application no:EP22166953  Date applied:2021

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  • Electrode device, electrophysiological recording system and computer program Major achievement

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    Application no:特願US17/325,579  Date applied:2020

    Announcement no:EP20177113.6A 

    Patent/Registration no:US20210369168A1  Date registered:2021 

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  • 生物輸送用システム Major achievement

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    Application no:特願2021-183136  Date applied:2020

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Awards

  • Summer Internship (Foreign Student, Host: Dr. Hajime Hirase)

    2006   RIKEN BSI  

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  • Armar and Umeko Strauss Scholarship and Stipend (MD/PhD Program)

    2002   Georgetown University  

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Teaching Experience (On-campus)

  • 解剖学A(組織学講義・実習)

    2024Year

  • Histology (Anatomy A)

    2024Year

  • Neuroscience

    2024Year

  • Introduction to Human Diseases

    2024Year

  • Advanced lecture on Neuroscien ce

    2024Year

  • Introduction to Human Diseases

    2023Year

  • Gross Anatomy (Anatomy B)

    2023Year

  • Advanced lecture on Neuroscien ce

    2023Year

  • Life Science of the Human Body

    2023Year

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Teaching Experience

  • FOCUS  Major achievement

    2024
    Institution:Institute of Science Tokyo

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  • Global Communication Workshop  Major achievement

    2024
    Institution:Tokyo Medical and Dental University

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  • iBSc Preparatory Course  Major achievement

    2024
    Institution:Tokyo Medical and Dental University

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  • 解剖A(組織学) 講義・実習  Major achievement

    2024
    Institution:山梨大学医学部

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  • Global Communication II  Major achievement

    2024
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    2025
    Institution:Tokyo Medical and Dental University

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  • ヒトの体と病気(医学科1年次)  Major achievement

    2023
    Institution:山梨大学

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  • 解剖B(発生学・骨学・肉眼解剖学) 講義・実習  Major achievement

    2023
    Institution:山梨大学医学部

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  • 大学院 神経科学特論  Major achievement

    2023
    Institution:山梨大学

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  • Science of the Human Body  Major achievement

    2023
    Institution:University of Yamanashi

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  • 大学院 歯学英語 非常勤講師

    2022
    Institution:神奈川歯科大学

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  • Advanced Livestock Utilization  Major achievement

    2022
    Institution:The University of Tokushima

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  • 医学英語(4年次)特別講義  Major achievement

    2021
    Institution:徳島大学

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  • Advanced Statistics for Neuroscience  Major achievement

    2018
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    2021
    Institution:Otto-von-Guericke University

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  • Scientific Writing (Tutor)  Major achievement

    2014
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    2017
    Institution:Otto-von-Guericke University

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  • ICOS-325 Disorders and Diseases of the Brain (Lecturer)  Major achievement

    2006
    Institution:Georgetown University

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  • Teaching Assistant: School of Medicine Neuroscience Course (Laboratory Session)

    2006
    Institution:Georgetown University

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  • Seminar Lecturer: HHMI Undergraduate Scholars Program at Georgetown University

    2005
    Institution:Georgetown University

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Social Activities

  • コロナ対応から見る世界の健康観念と社会観念

    Role(s): Lecturer

    徳島大学高大連携に係る講師派遣(出張講義)事業  2021.10

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    Type:Visiting lecture

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International Exchange and International Contribution

  • 2023  Type:International, regional exchange, exchange of students and Japanese students

    Committee on International Exchange

Professional Memberships

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Committee Memberships

  • National Board of Medical Examiners (NBME)   IMG Leader Roundtable   Major achievement

    2024   

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    Committee type:Others

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  •   山梨大学医学部 医学英語WG   Major achievement

    2023   

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  • 山梨大学医学域   国際交流委員会   Major achievement

    2023   

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  • 山梨大学   その他委員会(役職付き)  

    2023   

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  • 一般社団法人JrSr(ジュニアシニア)   HMEP Working Group / Extended Working Group   Major achievement

    2023   

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  • Leibniz Institut für Neurobiologie Magdeburg   IT改革委員会 委員長  

    2017 - 2019   

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  • JrSr Corporation   Working Group  

       

  • Hawaii Medical Education Program   Extended Working Group, Executive Chief Proctor  

       

  • National Board of Medical Examiners   IMG Leadership Roundtable  

       

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