Updated on 2026/05/01

写真a

 
Umeda Tatsuya
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine(Brain and Neural Systems Science) Professor
Title
Professor

Research History

  • University of Yamanashi   Graduate Faculty of Interdisciplinary Research Faculty of Medicine   Professor

    2025.9

  • Kyoto University   Associate Professor

    2020.5 - 2025.8

  • 国立精神・神経医療研究センター   神経研究所   室長

    2014.4 - 2020.5

  • Yokohama City University   Assistant Professor

    2013.4 - 2014.3

  • National Institute for Physiological Sciences

    2007.4 - 2013.3

  • 東京医科歯科大学 医歯(薬)学総合研究科   研究員

    2004.4 - 2006.9

  • 日本学術振興会   学術振興会特別研究員（DC2）

    2002.4 - 2004.3

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Education

  • Tokyo Medical and Dental University   Graduate School of Medical and Dental Sciences

    2000.4 - 2004.3

  • 東京大学大学院   理学系研究科   生物化学専攻 博士前期課程

    1998.4 - 2000.3

  • The University of Tokyo   Faculty of Science   Department of Biophysics and Biochemistry

    1996.4 - 1998.3

  • The University of Tokyo

    1994.4 - 1996.3

Research Areas

  • Life Science / Neuroscience-general

  • Life Science / Physiology

  • Life Science / Basic brain sciences

Research Interests

  • spinal cord

  • dorsal root ganglion

  • multichannel recording

  • マーモセット

  • スライス培養

  • GFP

  • 2光子顕微鏡

Subject of research

  • 疾患モデルマーモセットを用いた治療法開発

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    2014

  • 運動中の体性感覚知覚の神経基盤の解明

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    2008

Research Projects

  • 認知症克服に向けた脳のレジリエンスを支えるリザバー機能とその増強法の開発研究

    Grant number：25zf0127010s1302  2024.11 - 2030.10

    日本医療研究開発機構  ムーンショット型研究開発事業 

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    Authorship：Coinvestigator(s)  Grant type：Competitive  Type of fund：：Funded research

  • 手探りで物体の大きさを知覚する神経メカニズムの解明  Major achievement

    2024.4 - 2027.3

    文部科学省  学術研究助成基金助成金  基盤研究(B)

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    Authorship：Principal investigator  Grant type：Competitive  Type of fund：：Science research expense

  • 大脳皮質の単位神経回路における神経情報ダイナミクスの解明  Major achievement

    2024.4 - 2026.3

    日本学術振興会  科学研究費助成事業  学術変革領域研究（A)

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    Authorship：Principal investigator  Grant type：Competitive  Type of fund：：Science research expense

  • 神経生理学とレイヤーfMRI技術の融合による超階層な脳機能ダイナミクス計測法の開発 International coauthorship

    2024 - 2027.3

    国立研究開発法人日本医療研究開発機構  脳神経科学統合プログラム 

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    Authorship：Coinvestigator(s) 

  • 中枢・末梢神経系の統合的解析による随意運動制御の神経機構の解明

    2023.8 - 2028.3

    武田科学振興財団  ライフサイエンス研究継続助成 

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    Authorship：Principal investigator  Grant type：Competitive  Type of fund：：Donation

  • 霊長類モデル動物を用いた脳神経機能及びその疾患に関する基盤的研究

    2023.4 - 2026.3

    国立精神・神経医療研究センター  精神・神経疾患研究開発費 

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    Authorship：Coinvestigator(s)  Grant type：Competitive  Type of fund：：Funded research

  • 全脳活動データからメゾスケールの神経伝達を解読する超階層脳機能計測法の開発

    2023.4 - 2024.3

    清水免疫学・神経科学振興財団 

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    Authorship：Principal investigator 

  • 物体の大きさの知覚を形作る体性感覚－運動連関の解明

    2023.4 - 2024.3

    京都大学学術研究展開センター  いしずえ 

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    Authorship：Principal investigator 

  • 脳データ統合プラットフォームの開発と活用による脳機能と疾患病態の解明 International coauthorship

    2023.3 - 2030.3

    国立研究開発法人日本医療研究開発機構  脳神経科学統合プログラム 

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    Authorship：Coinvestigator(s)  Grant type：Competitive  Type of fund：：Funded research

  • 形状知覚を生み出す深部感覚－運動連関の解明

    2022.7 - 2023.3

    京都大学教育研究振興財団  研究活動推進助成 

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    Authorship：Principal investigator 

  • Development of somatosensory prosthesis with reference to somatosensory processing in the brain

    2021.10 - 2025.3

    AMED 

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    Authorship：Principal investigator 

  • 随意運動制御の新規神経機構の因果的検証

    2021.7 - 2022.3

    藤原記念財団  少壮研究者奨励金 

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    Authorship：Principal investigator 

  • 交通外傷に対するBMIを用いた運動機能再建の神経メカニズムの解明

    2021.4 - 2023.3

    JA共済総合研究所  JA共済 交通事故医療研究助成 

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    Authorship：Principal investigator 

  • 飼育ケージ内におけるサルの全脳機能評価システムの構築

    2020.11 - 2021.10

    予防衛生協会  NHP-A研究助成 

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    Authorship：Principal investigator 

  • 中枢・末梢神経系の統合的解析による随意運動制御の神経機構の解明

    2020.8 - 2022.5

    武田科学振興財団  ライフサイエンス研究助成 

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    Authorship：Principal investigator 

  • 能動的な感覚情報処理機構とその破綻の影響の解明

    2019.11 - 2020.12

    持田記念医学薬学振興財団  研究助成金 

    梅田達也

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    Authorship：Principal investigator  Grant type：Competitive 

  • 脳梗塞サルにおけるBMIを用いたリハビリテーションの回復メカニズムの解明

    2019.4 - 2022.3

    文部科学省  学術研究助成基金助成金（基盤C） 

    梅田達也

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    Authorship：Principal investigator  Grant type：Competitive 

  • 霊長類における皮質脊髄路の並列的情報処理機構の解明

    2015.4 - 2018.3

    文部科学省  学術研究助成基金助成金（基盤C） 

    梅田達也

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    Authorship：Principal investigator  Grant type：Competitive 

  • Development of a proprioceptive interface to restore proprioceptive sense by electrical stimulation of the primary sensory afferents.

    2015

    Medtronic  Medtronic Japan ERI 

    Tatsuya Umeda

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    Authorship：Principal investigator  Grant type：Competitive 

  • 脳血管障害とパーキンソン病における脳神経回路障害とその機能回復に関わるトランスレータブル脳・行動指標の開発

    2014.4 - 2019.3

    AMED  革新的技術による脳機能ネットワークの全容解明プロジェクト 

    高橋良輔

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    Grant type：Competitive 

  • 大脳皮質の複数の運動関連領野による脊髄運動性神経回路の制御機構の解明

    2013.4 - 2015.3

    文部科学省  科学研究費補助金（若手研究(B)） 

    梅田達也

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    Authorship：Principal investigator  Grant type：Competitive 

  • 幼若期大脳皮質損傷ラットにおける体性感覚経路の可塑的変化の解明

    2013

    成茂  成茂神経科学研究助成基金 

    梅田達也

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    Authorship：Principal investigator  Grant type：Competitive 

  • LTP形成におけるシナプス前部・後部の構造変化の解析

    Grant number：17700331  2005 - 2006

    文部科学省  科学研究費補助金(若手研究(B))  若手研究(B)

    梅田 達也

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    Grant type：Competitive 

    研究代表者は前年度において、海馬スライス培養中の錐体細胞の樹状突起においてLTPのようなシナプス可塑性を誘導する刺激を与えると、シナプス後部スパインのサイズが増大するといった複数の研究グループからの報告された実験を追試することができた。そこで、本年では研究代表者が開発した海馬スライス培養における接着するシナプス前部・後部構造の形態変化を同時観察する技術とスパインサイズを増大させる実験を組み合わせることで、LTP誘導刺激によってサイズが増大したスパインに接着するシナプス前部の形態がどのように変化するか実験を行った。しかしながら、複数の実験の結果、注目しているシナプス前部・後部構造のペアにおいてスパインのサイズの増大を検出することができなかった。サイズが増大するスパインを特定して刺激を与えることができなかったことが原因であった。今後、caged-glutamateを用いることで特定のスパインのサイズの増大を引き起こす実験を考えている。
    一方、LTP誘導刺激によるスパインのサイズの増大の細胞内分子メカニズムを調べるため、酵素活性の欠如した変異CaMKIIのノックインマウスを使用した実験を行った。その結果、ノックインマウス由来の海馬スライス培養中の錐体細胞をGFPで染色しその近傍をLTP誘導刺激を与えても、スパインサイズの増大を検出することができなかった。この実験から、スパインサイズ...

  • シナプス形成におけるカドヘリン分子の機能解析

    2002.4 - 2004.3

    日本学術振興会  特別研究員奨励費 

    梅田達也

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    Authorship：Principal investigator  Grant type：Competitive 

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Papers

  • Autogenic spinal excitatory circuit ensures skilled hand movements in primates Reviewed

    GeeHee Kim, Saeka Tomatsu, Tatsuya Umeda, Tomohiko Takei, Tetsuro Funato, Kazuhiko Seki

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   123 ( 12 )   2026.3( ISSN：0027-8424  eISSN：1091-6490 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Proceedings of the National Academy of Sciences  

    Skillful hand movements are a hallmark of primates, including humans, requiring sophisticated motor planning and execution. Building on the well-established cortical basis of dexterous control, our findings show that spinal excitatory reflex circuits form a critical complementary pathway that contributes substantially to the planning and execution of skillful hand movements. Using a combination of experimental approaches with behaving nonhuman primates and predictive simulation, we identified a group of excitatory spinal interneurons that orchestrate a closed-loop, positive feedback mechanism during voluntary wrist movements. This mechanism is characterized by a bidirectional interaction between interneuronal spiking and muscle activity, mediated by motoneuronal efferent signals and proprioceptive afferent signals from the same agonistic muscles. Furthermore, we demonstrate that the temporal profile of muscle activity during movement execution, including amplitude and duration, is predetermined during motor planning at the spinal interneurons, functioning as a force-feedback gain within the excitatory circuit. These findings suggest that autogenic, Ib spinal excitatory circuits play a predominant role in shaping overall muscle activation during motor execution, provided the proper reflex gain is preset by higher neural systems during motor planning. Together, our findings provide cellular-level evidence that spinal reflex loops operate in parallel with cortical mechanisms to support skilled voluntary movements in primates.

    DOI： 10.1073/pnas.2525051123

  • 予測する脳の原理に挑む Invited

    山梨新報   2026.2

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    Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：(MISC) Other article  

  • 意識的な運動制御と無意識的な脊髄反射を統合する運動制御の仕組み Invited

    梅田達也

    脳神経内科   103 ( 3 )   263 - 269   2025.9

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    Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Ultrahigh‐Field MR‐Compatible Mechanical Tactile Stimulator for Investigating Somatosensory Processing in Small‐Bodied Animals Reviewed International coauthorship Major achievement

    Chenyu Wang, Hirohiko Imai, Masaki Fukunaga, Hiroki Yamamoto, Yinghua Yu, Kazuhiko Seki, Takashi Hanakawa, Tatsuya Umeda, Jiajia Yang

    NMR IN BIOMEDICINE   38 ( 9 )   2025.7( ISSN：0952-3480  eISSN：1099-1492 )

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    ABSTRACT

    Common marmosets (Callithrix jacchus), small‐bodied New World primates that share similar sensory processing pathways with human beings, have gained great interests. Their small body size allows imaging of brain activity with high spatial resolution and on a whole‐brain scale using ultrahigh‐field (UHF) magnetic resonance imaging (MRI) scanners. However, the strong magnetic field and the small size of the hand and forearm pose challenges in delivering tactile stimulation during fMRI experiments. In the present study, we developed an MR‐compatible tactile dual‐point stimulator to provide high‐precision mechanical stimulation for exploring somatosensory processing in small‐bodied animals. The study population consisted of a water phantom and three male common marmosets. Cerebral blood volume (CBV) weighted fMRI data were obtained with a gradient echo (GE), echo‐planar imaging (EPI) sequence at 7T scanner. The output performance of the device was tested by a pressure sensor. The MR compatibility of the device was verified by measuring the temporal signal‐to‐noise ratio (tSNR) of a water phantom. To test the effectiveness of tactile stimulation, we conducted block designed tactile stimulation experiments on marmosets. A one‐way repeated measures ANOVA was conducted for comparing the tSNR results. We performed one‐sample t‐tests to investigate the negative response of the forearm and hand stimulation with a threshold of t > 1.96 (p < 0.05). Performance tests revealed that mechanical stimulation (averaged force: 31.69 g) was applied with a delay of 12 ms. Phantom experiments confirmed that there was no significant difference in the tSNR among three (10 Hz, 1 Hz, and no‐stimulus) conditions (F (2, 798) = 0.71, p = 0.49). The CBV activity results showed that the stimulator successfully elicited hand and forearm somatosensory activations in primary somatosensory areas. These results indicated that the device is well suited for small‐bodied animal somatosensory studies.

    DOI： 10.1002/nbm.70105

  • Future spinal reflex is embedded in primary motor cortex output. Reviewed Major achievement

    Tatsuya Umeda, Osamu Yokoyama, Michiaki Suzuki, Miki Kaneshige, Tadashi Isa, Yukio Nishimura

    Science Advances   10 ( 51 )   eadq4194   2024.12( ISSN：2375-2548 )

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Mammals can execute intended limb movements despite the fact that spinal reflexes involuntarily modulate muscle activity. To generate appropriate muscle activity, the cortical descending motor output must coordinate with spinal reflexes, yet the underlying neural mechanism remains unclear. We simultaneously recorded activities in motor-related cortical areas, afferent neurons, and forelimb muscles of monkeys performing reaching movements. Motor-related cortical areas, predominantly primary motor cortex (M1), encode subsequent afferent activities attributed to forelimb movement. M1 also encodes a subcomponent of muscle activity evoked by these afferent activities, corresponding to spinal reflexes. Furthermore, selective disruption of the afferent pathway specifically reduced this subcomponent of muscle activity, suggesting that M1 output drives muscle activity not only through direct descending pathways but also through the "transafferent" pathway composed of descending plus subsequent spinal reflex pathways. Thus, M1 provides optimal motor output based on an internal forward model that prospectively computes future spinal reflexes.

    DOI： 10.1126/sciadv.adq4194

    PubMed

  • Time course of recovery of different motor functions following a reproducible cortical infarction in non-human primates Reviewed Major achievement

    Akito Kosugi, Yosuke Saga, Moeko Kudo, Masashi Koizumi, Tatsuya Umeda, Kazuhiko Seki

    Frontiers in Neurology   14   2023.2(  eISSN：1664-2295 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

    A major challenge in human stroke research is interpatient variability in the extent of sensorimotor deficits and determining the time course of recovery following stroke. Although the relationship between the extent of the lesion and the degree of sensorimotor deficits is well established, the factors determining the speed of recovery remain uncertain. To test these experimentally, we created a cortical lesion over the motor cortex using a reproducible approach in four common marmosets, and characterized the time course of recovery by systematically applying several behavioral tests before and up to 8 weeks after creation of the lesion. Evaluation of in-cage behavior and reach-to-grasp movement revealed consistent motor impairments across the animals. In particular, performance in reaching and grasping movements continued to deteriorate until 4 weeks after creation of the lesion. We also found consistent time courses of recovery across animals for in-cage and grasping movements. For example, in all animals, the score for in-cage behaviors showed full recovery at 3 weeks after creation of the lesion, and the performance of grasping movement partially recovered from 4 to 8 weeks. In addition, we observed longer time courses of recovery for reaching movement, which may rely more on cortically initiated control in this species. These results suggest that different recovery speeds for each movement could be influenced by what extent the cortical control is required to properly execute each movement.

    DOI： 10.3389/fneur.2023.1094774

  • Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement Reviewed Major achievement

    Tatsuya Umeda, Tadashi Isa, Yukio Nishimura

    Proceedings of the National Academy of Sciences   119 ( 48 )   2022.11( ISSN：0027-8424  eISSN：1091-6490 )

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Proceedings of the National Academy of Sciences  

    Descending motor drive and somatosensory feedback play important roles in modulating muscle activity. Numerous studies have characterized the organization of neuronal connectivity in which descending motor pathways and somatosensory afferents converge on spinal motor neurons as a final common pathway. However, how inputs from these two pathways are integrated into spinal motor neurons to generate muscle activity during actual motor behavior is unknown. Here, we simultaneously recorded activity in the motor cortices (MCx), somatosensory afferent neurons, and forelimb muscles in monkeys performing reaching and grasping movements. We constructed a linear model to explain the instantaneous muscle activity using the activity of MCx (descending input) and peripheral afferents (afferent input). Decomposition of the reconstructed muscle activity into each subcomponent indicated that muscle activity before movement onset could first be explained by descending input from mainly the primary motor cortex and muscle activity after movement onset by both descending and afferent inputs. Descending input had a facilitative effect on all muscles, whereas afferent input had a facilitative or suppressive effect on each muscle. Such antagonistic effects of afferent input can be explained by reciprocal effects of the spinal reflex. These results suggest that descending input contributes to the initiation of limb movement, and this initial movement subsequently affects muscle activity via the spinal reflex in conjunction with the continuous descending input. Thus, spinal motor neurons are subjected to temporally organized modulation by direct activation through the descending pathway and the lagged action of the spinal reflex during voluntary limb movement.

    DOI： 10.1073/pnas.2208353119

  • Optogenetic recruitment of spinal reflex pathways from large-diameter primary afferents in non-transgenic rats transduced with AAV9/Channelrhodopsin 2. Reviewed

    Shinji Kubota, Wupuer Sidikejiang, Moeko Kudo, Ken-Ichi Inoue, Tatsuya Umeda, Masahiko Takada, Kazuhiko Seki

    The Journal of physiology   597 ( 19 )   5025 - 5040   2019.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    KEY POINTS: We demonstrated optical activation of primary somatosensory afferents with high selectivity to fast-conducting fibres by means of adeno-associated virus 9 (AAV9)-mediated gene transduction in dorsal root ganglion (DRG) neurons. AVV9 expressing green fluorescent protein showed high selectivity and transduction efficiency for fast-conducting, large-sized DRG neurons. Compared with conventional electrical stimulation, optically elicited volleys in primary afferents had higher sensitivity with stimulus amplitude, but lower sensitivity with stimulus frequency. Optically elicited dorsal root volleys activated postsynaptic neurons in the segmental spinal pathway. This proposed technique will help establish the causal relationships between somatosensory afferent inputs and neural responses in the CNS as well as behavioural outcomes in higher mammals where transgenic animals are not available. ABSTRACT: Previously, fundamental structures and their mode of action in the spinal reflex circuit were determined by confirming their input-output relationship using electrophysiological techniques. In those experiments, the electrical stimulation of afferent fibres was used as a core element to identify different types of reflex pathways; however, a major disadvantage of this technique is its non-selectivity. In this study, we investigated the selective activation of large-diameter afferents by optogenetics combined with a virus vector transduction technique (injection via the sciatic nerve) in non-transgenic male Jcl:Wistar rats. We found that green fluorescent protein gene transduction of rat dorsal root ganglion (DRG) neurons with a preference for medium-to-large-sized cells was achieved using the adeno-associated virus 9 (AAV9) vector compared with the AAV6 vector (P = 0.021). Furthermore, the optical stimulation of Channelrhodopsin 2 (ChR2)-expressing DRG neurons (transduced by AAV9) produced compound action potentials in afferent nerves originating from fast-conducting nerve fibres. We also confirmed that physiological responses to different stimulus amplitudes were comparable between optogenetic and electrophysiological activation. However, compared with electrically elicited responses, the optically elicited responses had lower sensitivity with stimulus frequency. Finally, we showed that afferent volleys evoked by optical stimulation were sufficient to activate postsynaptic neurons in the spinal reflex arc. These results provide new ways for understanding the role of sensory afferent input to the central nervous system regarding behavioural control, especially when genetically manipulated animals are not available, such as higher mammals including non-human primates.

    DOI： 10.1113/JP278292

    PubMed

  • Decoding of muscle activity from the sensorimotor cortex in freely behaving monkeys Reviewed Major achievement

    Umeda, T, Koizumi, M, Katakai, Y, Saito, R, Seki, K

    NeuroImage   197   512 - 526   2019.8

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

  • The somatosensory cortex receives information about motor output Reviewed Major achievement

    Umeda, T, Isa, T, Nishimura, Y, corresponding author

    Science Advances   5 ( 7 )   eaaw5388   2019.7

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    During voluntary movement, the somatosensory system not only passively receives signals from the external world but also actively processes them via interactions with the motor system. However, it is still unclear how and what information the somatosensory system receives during movement. Using simultaneous recordings of activities of the primary somatosensory cortex (S1), the motor cortex (MCx), and an ensemble of afferent neurons in behaving monkeys combined with a decoding algorithm, we reveal the temporal profiles of signal integration in S1. While S1 activity before movement initiation is accounted for by MCx activity alone, activity during movement is accounted for by both MCx and afferent activities. Furthermore, premovement S1 activity encodes information about imminent activity of forelimb muscles slightly after MCx does. Thus, S1 receives information about motor output before the arrival of sensory feedback signals, suggesting that S1 executes online processing of somatosensory signals via interactions with the anticipatory information.

    DOI： 10.1126/sciadv.aaw5388

    PubMed

  • Optogenetic activation of cutaneous and proprioceptive afferent in the rat sciatic nerve

    Kubota S, Sidikejiang W, Kudoh M, Inoue K, Umeda T, Takada M, Seki K

    Neuroscience 2018(2018/11/4, San Diego, USA）   2018.11

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    Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

  • In vivo electrophysiological evaluation of chanelrhodopsin-2-expressed dorsal root ganglion neurons in adults rats.

    Seki K, S Wupuer, Umeda T, Inoue K, Kudo M, Takada M

    2016.7

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    Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

  • Causal Link between the Cortico-Rubral Pathway and Functional Recovery through Forced Impaired Limb Use in Rats with Stroke

    Akimasa Ishida, Kaoru Isa, Tatsuya Umeda, Kazuto Kobayashi, Kenta Kobayashi, Hideki Hida, Tadashi Isa

    JOURNAL OF NEUROSCIENCE   36 ( 2 )   455 - 467   2016.1( ISSN：0270-6474 )

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.2399-15.2016

    Web of Science

  • Engineering approach for functional recovery based on body image adjustment by using biofeedback of electrical stimulation Reviewed

    Hiroshi Yokoi, Yuki Sato, Minako Suzuki, Yoshiko Yabuki, Tatsuhiro Nakamura, Takashi Mori, Soichiro Morishita, Ryu Kato, Osamu Yamamura, Masafumi Kubota, Tomoko Kamisawa, Chiaki Igarashi, Tadashi Isa, Tatsuya Umeda, Hidenori Watanabe, Yukio Nishimura, Katsunori Ikoma, Tamaki Miyamoto

    Clinical Systems Neuroscience   203 - 247   2015.1

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    Language：English   Publishing type：Part of collection (book)   Publisher：Springer Japan  

    DOI： 10.1007/978-4-431-55037-2_12

    Scopus

  • Decoding of the spike timing of primary afferents during voluntary arm movements in monkeys Reviewed Major achievement

    Tatsuya Umeda, Hidenori Watanabe, Masa-aki Sato, Mitsuo Kawato, Tadashi Isa, Yukio Nishimura

    FRONTIERS IN NEUROSCIENCE   8   97   2014.5( ISSN：1662-453X )

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fnins.2014.00097

    Web of Science

  • Reorganization of sensory pathways after neonatal hemidecortication in rats Reviewed International coauthorship Major achievement

    Oraphan Wanakhachornkrai, Tatsuya Umeda, Kaoru Isa, Mayuree H. Tantisira, Boonyong Tantisira, Tadashi Isa

    NEUROSCIENCE RESEARCH   79   94 - 98   2014.2( ISSN：0168-0102  eISSN：1872-8111 )

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neures.2013.11.003

    Web of Science

    PubMed

  • Reorganization of motor circuits after neonatal hemidecortication Reviewed Major achievement

    Tatsuya Umeda, Kengo Funakoshi

    NEUROSCIENCE RESEARCH   78   30 - 37   2014.1( ISSN：0168-0102  eISSN：1872-8111 )

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neures.2013.08.011

    Web of Science

    PubMed

  • A pilot study for the development of a portable leukocytapheresis system Reviewed

    NOISHIKI Yasuharu, TAKEDA Yuma, UMEDA Tatsuya, ATOBE Yoshitoshi, TAKEDA Akihito, KANEKO Kanichiro, TAKIGUCHI Masahito, FUNAKOSHI Kengo

    Japanese Journal of Apheresis   33 ( 3 )   202 - 207   2014( ISSN：1340-5888 )

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    In order to develop a portable leukocytapheresis system, an animal pilot study was performed using a blood-circulating tube of 3 mm in ID, and 40 cm in length having a leukocyte wall-trap made up of 2 kinds of fabric, 7 cm in length each, on the luminal wall. One fabric tube was made of ultra-fine (3.3 μOD) polyester fibers (UFPFs), and the other was made of regular-sized (16 μOD) polyester fibers (RPFs). This was based on the rolling phenomenon of leukocytes in a small caliber blood vessel wall, the laminar flow phenomenon, and the thygmotaxis phenomenon. Blood circulation from the left jugular vein to the left femoral vein was performed for two hours in a dog treated with heparin without using any pump. The amount of blood flow in the tube was approximately 160 ml/min. Sections of each fabric were examined light-microscopically. Leukocytes were trapped in the interstices of UFPFs 5 times more than in RPFs. Leukocytes were effectively trapped under a condition of low blood-flow resistance. These results indicated that leukocyte wall-trapping with UFPFs is effective. A portable leukocytapheresis system will be devised using wall-trapping in the near future.

    CiNii Books

    Other Link： http://id.nii.ac.jp/1141/00152217/

  • サル硬膜下電位からのリーチングタスクの状態判別率向上を目指した次元圧縮法

    坂井郁也, 森下壮一郎, 西村幸男, 渡辺秀典, 加藤龍, 梅田達也, 伊佐正, 横井浩史

    自律分散システム・シンポジウム(CD-ROM)   26th   2014

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    J-GLOBAL

  • Proprioceptive information coded by populational sensory afferents Invited Reviewed Major achievement

    Umeda, T, Isa, T, Nishimura, Y, corresponding author

    J. Phys. Fitness. Sports. Med   3   477 - 482   2014

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

  • Estimation of Firing Pattern of Primary Afferents from Joint Kinematics During Voluntary Arm Movements of Monkeys

    Umeda Tatsuya, Sato Masa-aki, Kawato Mitsuo, Isa Tadashi, Nishimura Yukio

    BME   51   M - 73-M-73   2013( ISSN：1347-443X )

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    Authorship：Lead author   Language：English   Publishing type：(MISC) Summary of the papers read (international conference)   Publisher：Japanese Society for Medical and Biological Engineering  

    DOI： 10.11239/jsmbe.51.M-73

  • Population Coding of Forelimb Joint Kinematics by Peripheral Afferents in Monkeys Reviewed Major achievement

    Tatsuya Umeda, Kazuhiko Seki, Masa-aki Sato, Yukio Nishimura, Mitsuo Kawato, Tadashi Isa

    PLOS ONE   7 ( 10 )   e47749   2012.10( ISSN：1932-6203 )

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0047749

    Web of Science

    PubMed

  • fMRI analysis of prosthetic hand rehabilitation using a brain-machine interface

    Hiroshi Yokoi, Keita Sato, Souichiro Morishita, Tatuhiro Nakamura, Ryu Kato, Tatsuya Umeda, Hidenori Watanabe, Yukio Nishimura, Tadashi Isa, Katsunori Ikoma, Tamaki Miyamoto, Osamu Yamamura

    Advances in Therapeutic Engineering   219 - 250   2012.1

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    Language：English   Publishing type：Part of collection (book)   Publisher：CRC Press  

    DOI： 10.1201/b13729

    Scopus

  • Differential contributions of rostral and caudal frontal forelimb areas to compensatory process after neonatal hemidecortication in rats Reviewed Major achievement

    Tatsuya Umeda, Tadashi Isa

    EUROPEAN JOURNAL OF NEUROSCIENCE   34 ( 9 )   1453 - 1460   2011.11( ISSN：0953-816X )

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1460-9568.2011.07866.x

    Web of Science

    PubMed

  • Canonical correlation analysis (CCA) of multi-joint motion (JM) and dorsal root ganglion (DRG) neuronal activities

    Jun Morimoto, Tatsuya Umeda, Yukio Nishimura, Tadashi Isa, Mitsuo Kawato, Keisuke Toyama

    NEUROSCIENCE RESEARCH   71   E201 - E201   2011( ISSN：0168-0102 )

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    Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

    DOI： 10.1016/j.neures.2011.07.871

    Web of Science

  • Extracting neuronal ensemble from dorsal root ganglia to encode hand/arm trajectories in monkeys

    Tatsuya Umeda, Masa-aki Sato, Mitsuo Kawato, Tadashi Isa

    NEUROSCIENCE RESEARCH   71   E261 - E261   2011( ISSN：0168-0102 )

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    Authorship：Lead author   Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

    DOI： 10.1016/j.neures.2011.07.1140

    Web of Science

  • Formation of Descending Pathways Mediating Cortical Command to Forelimb Motoneurons in Neonatally Hemidecorticated Rats Reviewed Major achievement

    Tatsuya Umeda, Masahito Takahashi, Kaoru Isa, Tadashi Isa

    JOURNAL OF NEUROPHYSIOLOGY   104 ( 3 )   1707 - 1716   2010.9( ISSN：0022-3077 )

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/jn.00968.2009

    Web of Science

    PubMed

  • Classification analysis of Monkey ECoG data for reaching motion Reviewed

    Keita Sato, Tatsuhiro Nakamura, Soichiro Morishita, Tatsuya Umeda, Hidenori Watanabe, Ryu Kato, Tadashi Isa, Hiroshi Yokoi

    UEC & SJTU Proceedings of 3rd International Symposium on Robot and Artificial Intelligence   確認中   2010.6

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    Language：English   Publishing type：Research paper (international conference proceedings)  

  • Coding of hand/arm trajectories by neuronal activity in dorsal root ganglia of monkeys

    Tatsuya Umeda, Tomoya Sakatani, Jun Morimoto, Okito Yamashita, Masaaki Satoh, Kazuhiko Seki, Mitsuo Kawato, Tadashi Isa

    NEUROSCIENCE RESEARCH   68   E326 - E327   2010( ISSN：0168-0102 )

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    Authorship：Lead author   Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

    DOI： 10.1016/j.neures.2010.07.1447

    Web of Science

  • Estimation of common features shared by multiple sensor data including neural recordings

    Jun Morimoto, Tatsuya Umeda, Tomoya Sakatani, Tadashi Isa, Mitsuo Kawato

    NEUROSCIENCE RESEARCH   68   E214 - E214   2010( ISSN：0168-0102 )

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    Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

    DOI： 10.1016/j.neures.2010.07.2517

    Web of Science

  • Large-scale reorganization of corticofugal fibers after neonatal hemidecortication for functional restoration of forelimb movements Reviewed International coauthorship Major achievement

    Masahito Takahashi, Anusara Vattanajun, Tatsuya Umeda, Kaoru Isa, Tadashi Isa

    EUROPEAN JOURNAL OF NEUROSCIENCE   30 ( 10 )   1878 - 1887   2009.11( ISSN：0953-816X )

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1460-9568.2009.06989.x

    Web of Science

    PubMed

  • Kinase-Dead Knock-In Mouse Reveals an Essential Role of Kinase Activity of Ca2+/Calmodulin-Dependent Protein Kinase II alpha in Dendritic Spine Enlargement, Long-Term Potentiation, and Learning Reviewed

    Yoko Yamagata, Shizuka Kobayashi, Tatsuya Umeda, Akihiro Inoue, Hiroyuki Sakagami, Masahiro Fukaya, Masahiko Watanabe, Nobuhiko Hatanaka, Masako Totsuka, Takeshi Yagi, Kunihiko Obata, Keiji Imoto, Yuchio Yanagawa, Toshiya Manabe, Shigeo Okabe

    JOURNAL OF NEUROSCIENCE   29 ( 23 )   7607 - 7618   2009.6( ISSN：0270-6474 )

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.0707-09.2009

    Web of Science

    PubMed

  • COMPENSATORY CORTICOMOTONEURONAL CONNECTIONS IN RATS WITH NEONATAL HEMIDECORTICATION

    Tatsuya Umeda, Masahito Takahashi, Anusara Vattanajun, Kaoru Isa, Tadashi Isa

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   339 - 339   2009( ISSN：1880-6546 )

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    Authorship：Lead author   Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

    Web of Science

  • THE ROLE OF KINASE ACTIVITY OF Ca2+/CALMODULIN-DEPENDENT PROTEIN KINASE II IN HIPPOCAMPAL SYNAPTIC PLASTICITY AND LEARNING

    Yoko Yamagata, Shizuka Kobayashi, Tatsuya Umeda, Akihiro Inoue, Hiroyuki Sakagami, Masahiro Fukaya, Masahiko Watanabe, Nobuhiko Hatanaka, Masako Totsuka, Takeshi Yagi, Kunihiko Oabata, Keiji Imoto, Yuchio Yanagawa, Toshiya Manabe, Shigeo Okabe

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   182 - 182   2009( ISSN：1880-6546 )

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    Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

    Web of Science

  • Kinase activity of CaMKII alpha is essential for structural, functional and behavioral expression of synaptic memory

    Yoko Yamagata, Shizuka Kobayashi, Tatsuya Umeda, Akihiro Inoue, Hiroyuki Sakagami, Masahiro Fukaya, Masahiko Watanabe, Nobuhiko Hatanaka, Masako Totsuka, Takeshi Yagi, Kunihiko Obata, Keiji Imoto, Yuchio Yanagawa, Toshiya Manabe, Shigeo Okabe

    NEUROSCIENCE RESEARCH   65   S144 - S144   2009( ISSN：0168-0102  eISSN：1872-8111 )

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    Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

    DOI： 10.1016/j.neures.2009.09.726

    Web of Science

  • Reorganization of corticospinal tract in rats with neonatal hemidecortication

    Tatsuya Umeda, Kaoru Isa, Tadashi Isa

    NEUROSCIENCE RESEARCH   61   S182 - S182   2008( ISSN：0168-0102 )

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    Authorship：Lead author   Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

    Web of Science

  • Large-scale change in the corticofugal projections in rats with neonatal hemi-decortication International coauthorship

    Masahito Takahashi, Anusara Vattanajun, Tatsuya Umeda, Kaoru Isa, Tadashi Isa

    NEUROSCIENCE RESEARCH   58   S91 - S91   2007( ISSN：0168-0102 )

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    Language：English   Publishing type：(MISC) Summary of the papers read (international conference)  

    Web of Science

  • Simultaneous observation of stably associated presynaptic varicosities and postsynaptic spines: morphological alterations of CA3-CA1 synapses in hippocampal slice cultures Reviewed Major achievement

    T Umeda, T Ebihara, S Okabe

    MOLECULAR AND CELLULAR NEUROSCIENCE   28 ( 2 )   264 - 274   2005.2( ISSN：1044-7431 )

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.mcn.2004.09.010

    Web of Science

    PubMed

  • Electroporation-mediated gene transfer system applied to cultured CNS neurons Reviewed

    Kawabata, I, T Umeda, K Yamamoto, S Okabe

    NEUROREPORT   15 ( 6 )   971 - 975   2004.4( ISSN：0959-4965 )

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/01.wnr.0000124798.77125.32

    Web of Science

    PubMed

  • Postsynaptic expression of a new calcium pathway in hippocampal CA3 neurons and its influence on mossy fiber long-term potentiation Reviewed

    W Kakegawa, N Yamada, M Iino, K Kameyama, T Umeda, K Tsuzuki, S Ozawa

    JOURNAL OF NEUROSCIENCE   22 ( 11 )   4312 - 4320   2002.6( ISSN：0270-6474 )

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    Language：English   Publishing type：Research paper (scientific journal)  

    Web of Science

    PubMed

  • Visualizing synapse formation and remodeling: recent advances in real-time imaging of CNS synapses Reviewed

    T Umeda, S Okabe

    NEUROSCIENCE RESEARCH   40 ( 4 )   291 - 300   2001.8( ISSN：0168-0102 )

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Web of Science

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Presentations

  • 能動的探索行動における一次体性感覚野の層別情報動態～マーモセットにおける３次元電極記録～  Invited

    梅田達也

    第5回霊長類の神経科学研究における若手連携の会  2026.3 

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    Event date： 2026.3

    Language：Japanese   Presentation type：Oral presentation(invited, special)  

    Venue：道後温泉ホテル椿館  

  • マーモセット研究基盤の新規立ち上げ Invited Major achievement

    梅田達也

    Primatech2026  2026.2 

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    Event date： 2026.2

    Language：Japanese   Presentation type：Symposium workshop panel(nominated)  

    Venue：東北大学  

  • 多階層・並列的運動回路における脊髄反射の制御戦略の解明 Major achievement

    梅田達也

    生理研セミナー  2026.1 

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    Event date： 2026.1

    Language：Japanese   Presentation type：Public discourse, seminar, tutorial, course, lecture and others  

    Venue：生理学研究所  

  • 能動的探索行動における一次体性感覚野の層別情報動態 Major achievement

    梅田達也

    第15回日本マーモセット研究会大会  2026.1  日本マーモセット研究会

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    Event date： 2026.1

    Language：Japanese   Presentation type：Poster presentation  

    Venue：高崎シティギャラリー  

  • 能動的探索行動における一次体性感覚野の層別情報動態：マーモセットにおける3次元電極記録 Invited Major achievement

    梅田達也

    霊長類ニューロサイエンス研究会  2025.9  生理学研究所・北海道大学医学研究院ジョイント研究会

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    Event date： 2025.9

    Language：Japanese   Presentation type：Oral presentation(invited, special)  

    Venue：北海道大学  

Awards

  • 技術創造賞

    2024.12   日本機械学会中国四国支部  

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    Award type：Award from Japanese society, conference, symposium, etc. 

  • BioLegend/Tomy Digital Biologyトラベルアワード

    2014.11   Tomy Digital  

    梅田達也

  • 優秀発表賞

    2010.5   Motor control研究会  

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    Award type：Award from Japanese society, conference, symposium, etc. 

Other

  • スポーツジャパン誌解説

    2025.6
    -
    2025.7

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    スポーツジャパン誌の特集「内なる声にもっと耳を！」において「一次運動野の働き、運動制御の新たなメカニズム」を解説

Teaching Experience (On-campus)

  • Neuroscience

    2026Year

  • Life Science of the Human Body

    2026Year

  • Introduction to Human Morphology and Function

    2026Year

  • Introduction to Human Pathophysiology

    2026Year

  • 医学研究 Major achievement

    2025Year  Type of subject：Professional education (undergraduate)

    医学研究の研究室配属を担当

Teaching Experience

  • 医学研究

    2026.1
    Institution：山梨大学

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    Level：Undergraduate (specialized) 

  • 神経科学

    2025.9
    Institution：山梨大学

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    Level：Undergraduate (specialized) 

  • Physiology

    2023
    -
    2024
    Institution：Kyoto University

  • Physiology

    2023
    Institution：Kanazawa University

  • Neuroscience

    2020
    Institution：Kyoto University

  • Brain anatomy

    2020
    Institution：Kyoto University

  • Gross Anatomy

    2020
    -
    2025
    Institution：Kyoto University

  • Frontiers in Neuroscience research

    2014
    -
    2019
    Institution：Waseda University

  • 組織学実習・講義

    2013
    Institution：横浜市立大学

  • 解剖学実習

    2013
    Institution：横浜市立大学

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Guidance results

  • 2025

    Type：Achievement of student guidance (Undergraduate)

    Number of people receiving guidance ：1people 

  • 2025

    Type：Achievement of student guidance (graduate school)

    Number of people receiving guidance ：2people  (Overseas students)：1people

Teaching achievements

  • 第４回全学教育FD研修会参加

    2025.11.19

Professional Memberships

  • 日本解剖学会

  • THE JAPAN NEUROSCIENCE SOCIETY Major achievement

  • PHYSIOLOGICAL SOCIETY OF JAPAN

  • Society for Neuroscience

  • The Japanese society for motor contro;

Media Coverage

  • 無意識に起きる「脊髄反射」を脳は事前に予測している！？ Internet

    公益財団法人テルモ生命科学振興財団  生命科学DOKIDOKI研究室  https://www.terumozaidan.or.jp/labo/technology/68/index.html  2025.9

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    Author：Other 

  • 中高年の転倒 脳の誤認識が影響か Newspaper, magazine

    毎日新聞  毎日新聞  科学の森  2025.4

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    Author：Other