Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

The treatment of magnetite nanoparticle thin films with potassium phosphate and their surface reaction with simulated body fluid were in situ monitored by the QCM-D technique, which is suitable for the precipitation of calcium phosphate.

DOI： 10.1039/d4re00048j

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

This review described the highlight of surface engineering of hydroxyapatite nanoparticles and their interactions with ions and molecules, and summarized how the surface functionalization effectively work in biological situations.

DOI： 10.1039/d4tb00551a

Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

Titania and silica have been recognized as potential drug delivery system (DDS) carriers. For this application, controllable biocompatibility and the suppression of the initial burst are required, which can be provided by a calcium phosphate (CP) coating. However, it is difficult to control the morphology of a CP coating on the surface of carrier particles owing to the homogeneous nucleation of CP. In this study, we report the development of a CP-coating method that homogeneously corresponds to the shapes of silica–titania (SiTi) porous nanoparticles. We also demonstrate that controlled surface roughness of CP coatings could be achieved in SBF using SiTi nanoparticles with a well-defined spherical shape, a uniform size, and a tunable nanoporous structure. The precipitation of CP was performed on mono-dispersed porous SiTi nanoparticles with different Si/Ti molar ratios and pore sizes. The pore size distribution was found to significantly affect the CP coating in SBF immersion; the surfaces of the nanoparticles with bimodal pore sizes of 0.7 and 1.1–1.2 nm became rough after CP precipitation, while those with a unimodal pore size of 0.7 nm remained smooth, indicating that these two pore sizes serve as different nucleation sites that lead to different surface morphologies.

DOI： 10.3390/inorganics11060235

Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

DOI： 10.1021/acsanm.2c04358

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

DOI： 10.1021/acsabm.2c00756

Authorship：Lead author   Language：English   Publisher：MDPI AG  

Theranostics (bifunction of therapeutics and diagnostics) has attracted increasing attention due to its efficiency that can reduce the physical and financial burden on patients. One of the promising materials for theranostics is calcium phosphate (CP) and it is biocompatible and can be functionalized not only with drug molecules but also with rare earth ions to show photoluminescence that is necessary for the diagnostic purpose. Such the CP-based hybrids are formed in vivo by interacting between functional groups of organic molecules and inorganic ions. It is of great importance to elucidate the interaction of CP with the photofunctional species and the drug molecules to clarify the relationship between the existing state and function. Well-designed photofunctional CPs will contribute to biomedical fields as highly-functional ormultifunctional theranostic materials at the nanoscales. In this review, we describe the hybridization between CPs and heterogeneous species, mainly focusing on europium(III) ion and methylene blue molecule as the representative photofunctional species for theranostics applications.

DOI： 10.3390/molecules27185916

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

Interfacial interactions between anionic porphyrin (TCPP) and α-tricalcium phosphate in hydrolysis reaction were clarified, and the orientation of TCPP molecules on the reactive calcium phosphates can be controlled by the mineralization process.

DOI： 10.1039/d2ce00505k

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

DOI： 10.1021/acs.inorgchem.1c03569

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

The promotion of the K-ion introduction into Ca-deficient hydroxyapatite (CDHA) via a citric acid coordination technique was clarified, resulting in a characteristic phase transition via the thermal stabilization of K-ion-doped CDHA.

DOI： 10.1039/d2dt01488b

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

Abstract

Alpha‐tricalcium phosphate (α‐TCP), which can be converted to calcium‐deficient hydroxyapatite (HA) by hydrolysis reaction, has been researched as a bone filling. Although the composites of α‐TCP with various organic molecules can exhibit a novel functionality, the reaction based on the addition of the interactive organic molecules has not been understood. Investigation of the hydrolysis conversion process under various conditions can lead to the elucidation of the biomineralization process. In this study, we investigated the hydrolysis conversion of α‐TCP to HA in the presence of orotic acid (Ort). As a result, the conversion rate from α‐TCP to HA at the reaction time of 3 h was improved to be more than five times as compared to that in the absence of Ort. Moreover, the addition of Ort promoted the crystal growth and suppressed the crystal growth in the m‐plane direction. Furthermore, the mechanism for promoting HA formation is assumed to be related to the molecular structure of Ort, which is capable of forming the interactions between carboxylate and Ca²⁺ ions.

DOI： 10.1002/ces2.10109

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ces2.10109

Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

DOI： 10.1021/acs.inorgchem.1c00718

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

DOI： 10.1021/acs.cgd.0c01369

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.rinp.2019.102215

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.colcom.2019.100185

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.apt.2019.02.021

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.colcom.2019.100182

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.matchemphys.2019.01.071

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.matchemphys.2018.09.058

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Society of Polymer Science, Japan  

DOI： 10.1295/koron.2017-0054