Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine (Immunology) Assistant Professor
Title
Assistant Professor
Ishimaru Kayoko
Research History
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University of Yamanashi Univercity of Yamanashi Assistant Professor
2018.4
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University of Yamanashi (Department of Immunology) Research Assistant Professor
2013.4 - 2018.3
Education
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University of Yamanashi Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences Department of Biomedical Science
2019.4 - 2020.9
Country： Japan
Course： Master course
Degree
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Master of Life Science ( 2020.9 University of Yamanashi )
Research Areas
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Life Science / Immunology
Research Interests
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Allergy, mast cell, circadian clock
Research Projects
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脳内ドーパミン報酬系活性化によるアレルギー反応抑制機序の解析
2022.4 - 2025.3
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REV-ERBアゴニストによるⅠ型アレルギー反応抑制機序の解析
2019.4 - 2021.3
日本学術振興会 科学研究費助成事業 基盤研究（C)
Authorship：Principal investigator Type of fund：：Science research expense
Papers
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Cha o 3, a cypress polle allergen, does not activate basophils in Japanese cypress pollinosis Reviewed
Journal of Allergy and Clinical Immunology: Global 2023.12
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Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation. Reviewed
International Journal of Molecular Sciences 2023.6
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Probiotic supplementation and human milk cytokine profiles in Japanese women: a retrospective study from an open-label pilot study. Reviewed
Nutrients 13 ( 7 ) 2285 2021.6( ISSN：2072-6643 )
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The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock. Reviewed
Ishimaru K, Nakajima S, Yu G, Nakamura Y, Nakao A
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 ( 24 ) 6320 2019.12( ISSN：1422-0067 )
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Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis. Reviewed
3.Nakajima S,Ishimaru K, Kobayashi A, Yu G, Nakamura Y, Oh-oka K, Suzuki-Inoue K, Kono K, Nakao A
Scientific Reports 9 ( 1 ) 18423 2019.12( ISSN：2045-2322 )
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Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells. Reviewed
Nakamura Y, Sasaki T, Mochizuki C, Ishimaru K, Koizumi S, Shinmori H, Suzuki-Inoue K, Nakao A
Scientific Reports 9 ( 1 ) 15958 2019.11( ISSN：2045-2322 )
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Time-restricted feeding in rest phase alters IgE/mast cell–mediated allergic reaction in mice. Reviewed
Nakamura Y, Ishimaru K, Nakao A
ALLERGOLOGY INTERNATIONAL 2019.10( ISSN：1323-8930 )
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Effects of Probiotic Supplementation on TGF-β1, TGF-β2, and IgA Levels in the Milk of Japanese Women: An Open-Label Pilot Study. Reviewed
Takahashi T, Fukudome H, Ueno HM, Watanabe-Matsuhashi S, Nakano T, Kobayashi T, Ishimaru K, Nakao A.
6 ( 128 ) 2019.9
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Differential Day-Night Outcome to HSV-2 Cutaneous Infection Reviewed
Matsuzawa T, Nakamura Y, Ogawa Y, Ishimaru K, Goshima F, Shimada S, Nakao A, Kawamura T
JOURNAL OF INVESTIGATIVE DERMATOLOGY 138 ( 1 ) 233 - 236 2017.8( ISSN：0022-202X )
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The frequency of Th17 cells in the small intestine exhibits a dayenight variation dependent on circadian clock activity. Reviewed
Thu Le HP, Nakamura Y, Oh-oka K, Ishimaru K, Nakajima S, Nakao A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 490 ( 2 ) 290 - 295 2017.8( ISSN：0006-291X )
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Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor. Reviewed
Oh-oka K, Kojima Y, Uchida K, Yoda M, Ishimaru K, Nakajima S, Hemmi J, Kano H, Fujii-Kuriyama Y, Katoh R, Ito H, Nakao A
Cellular and Molecular Gastroenterology and Hepatology 4 ( 1 ) 135 - 151 2017.7
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Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response. Reviewed Major achievement
Ishimaru K*, Kawauchi T*, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A(*Thease authers contributed equally to this work.)
ALLERGOLOGY INTERNATIONAL 66 ( 3 ) 472 - 478 2017.3( ISSN：1323-8930 )
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Regulation of plasma histamine levels by the mast cell clock and its modulation by stress. Reviewed Major achievement
Scientific Reports 7 39934 2017.1
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The Efficacy of Sublingual Immunotherapy for Allergic Rhinitis May Vary with the Time of Day. Reviewed Major achievement
Int Arch Allergy Immunol 171 ( 2 ) 111 - 118 2016.12
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Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock. Reviewed Major achievement
J Allergy Clin Immunol 137 ( 4 ) 1226 - 1235 2016.4
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Circadian Gene Clock Regulates Psoriasis-Like Skin Infammation in Mice Reviewed Major achievement
Journal of Investigative Dermatology 135 ( 12 ) 3001 - 3008 2015.12
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Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis Reviewed Major achievement
Allergy 70 ( 3 ) 319 - 322 2015.3
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Comparison of colostrum TGF-β2 levels between lactating women in Japan and Nepal Reviewed Major achievement
Asian Pacific Journal of Allergy and Immunology 32 ( 2 ) 178 - 184 2014.6
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Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis Reviewed Major achievement
PLoS One 9 ( 5 ) e98016 2014.5
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Identification of a probiotic bacteria-derived activator of the aryl hydrocarbon receptor that inhibits colitis Reviewed Major achievement
Immunology and Cell Biology 92 ( 5 ) 460 - 465 2014.5
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Disruption of the Suprachiasmatic Nucleus Blunts A Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice. Reviewed Major achievement
474217 2014.4
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Residential Area, Birth Order, and Dietary Habit May Influence TSLP Levels in Colostrum: Comparative Study between Japan and Nepal. Reviewed Major achievement
Yoko AIHARA,Naoki KONDO,Jyoti SHARMA,Narayan C SHRESTHA,Kayoko ISHIMARU,Hara mutuko,Zentaro YAMAGATA,Atsuhito NAKAO,Kyoko Oh-oka
Allergology International 63 283 - 285 2014.3
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Circadian regulation of allergic reaction by the mast cell clock in mice. Reviewed Major achievement
Yuki NAKAMURA,Nobuhiro NAKANO,Kayoko ISHIMARU,Mutsuko HARA,Takako IKEGAMI,Atsuhito NAKAO
J Allergy Clin Immun 133 ( 2 ) 568 - 575.e12 2014.2
Presentations
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The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock.
Ishimaru K, Nakao A
2021.11
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スギ花粉症モデルマウスを用いた舌下免疫療法(SLIT)クロノセラピーの検討 Major achievement
五十嵐 賢,鈴木 啓介,中村 勇規,石丸 かよ子,深野 千陽,増山 敬祐,土井 雅津代,中尾 篤人
第34回日本耳鼻咽喉科免疫アレルギー学会 2016.2
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Ciracadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice Major achievement
The 40th Annual Meeting of the Japanese Society for Investigative Dermatology 2015.12
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スギ花粉症患者好塩基球のスギ花粉に対する反応性の日内変動 Major achievement
安藤 典子,中村 勇規,石丸 かよ子,島田 眞路,中尾 篤人
第64回日本アレルギー学会学術大会 2015.5
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授乳婦への乳酸菌・ビフィズス菌投与による母乳成分への影響. Major achievement
中尾 篤人,石丸 かよ子,福留博文,渡辺汐美,中埜拓
日本食品免疫学会設立10周年記念学術大会 2014.10
Awards
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Gender Equality Encouragement Award for Academic Research of University of Yamanashi
2017.10
Guidance results
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2022
Type：Achievement of student guidance (graduate school)
Number of people receiving guidance ：2people (Overseas students)：2people
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2021
Type：Master's （Major B course）dissertations guidance
Number of people receiving guidance ：1people
Graduation / pass / number of people awarded degrees ：1people
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2021
Type：Achievement of student guidance (graduate school)
Number of people receiving guidance ：1people (Overseas students)：1people
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2020
Type：Achievement of student guidance (graduate school)
Number of people receiving guidance ：1people
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2019
Type：Undergraduate （Major A course）graduation thesis guidance
Number of people receiving guidance ：1people
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2019
Type：Achievement of student guidance (graduate school)
Number of people receiving guidance ：1people
Social Activities
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The mechanism of Allergy
Role(s)： Lecturer
2018.9
Professional Memberships
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Japanease Society of Allergology
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Japanese Association for Food Immunology