2002年4月～2005年8月 Visiting fellow in National Institute of Child health and Human development, Nationa

2002.4

2001年4月～2002年3月　日本学術振興会特別研究員

2001.4

Decreased postprandial glucose and insulin secretion after co-ingestion of barley mixed rice with yam paste in healthy Japanese participants: a randomized crossover trial Reviewed

Matsuoka T, Yamaji A, Kurosawa C, Shinohara M, Takayama I, Nakagomi H, Izumi K, Ichikawa Y, Hariya N, Mochizuki K.

ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION   2023.4( ISSN：0964-7058 )

Medium-Chain Triglycerides Reduce Glomerulosclerosis and Induce Redox Genes Level of NSY Mice with Diabetic Nephropathy Reviewed

Hagiwara M, Ishiyama S, Mochizuki K.

PharmaNutrition   2023.3( ISSN：2213-4344 )

Environment and Children’s Study Group. Maternal protein intake in early pregnancy and child development at age 3 years Reviewed

Miyake K, Mochizuki K, Kushima M, Shinohara R, Horiuchi S, Otawa S, Akiyama Y, Ooka T, Kojima R, Yokomichi H, Yamagata Z; Japan Environment and Children’s Study Group

PEDIATRIC RESEARCH   2023.1( ISSN：0031-3998 )

β-Carotene enhances the expression of inflammation-related genes and histone H3 K9 acetylation, K4 dimethylation, and K36 trimethylation around these genes in juvenile macrophage-like THP-1 cells. Reviewed

Kondo S, Suzuki R, Nakashima Y, Mochizuki K

Biochemistry and Biophysics Reports   2022.12

Supra-Multifactorial Survey YHAB revealed Highly Prevalent Sleep Apnoea Syndrome in Unaware Older Adults and Potential Combinatorial Factors for Its Initial Screening. Reviewed

Tanaka Y, Ando T, Mochizuki K, Igarashi S, Tsuchiya K, Saito K, Ito Y, Yamagata Z, Iwasaki M, YHAB Health Group.

Front Aging   2022.10

大麦摂取は2型糖尿病患者の血清尿酸高値を低下させる Reviewed

遅野井健，道口佐多子，久賀なつみ，横田由夏，飛田春菜，大渕健介，斎藤三代子，丸山聡子，望月和樹，加藤誠

診療と新薬   2022.9( ISSN：0037-380X )

From lessons on the long-term effects of the preimplantation environment on later health to a "modified ART-DOHaD" animal model Reviewed

Bari MW, Ishiyama S, Matsumoto S, Mochizuki K and Kishigami S

Reproductive Medicine and Biology   2022.7( ISSN：1445-5781 )

Protein restriction during the fetal period upregulates IL1B and IL13 while suppressing MUC2 expression in the jejunum of mice after weaning Reviewed

NUTRITION   2022.6( ISSN：0899-9007 )

Medium-chain fatty acids enhance expression and histone acetylation of genes related to lipid metabolism in insulin-resistant adipocytes Reviewed

Kawamura M, Goda N, Hariya N, Kimura M, Ishiyama S, Kubota T, Mochizuki K.

None   2022.3

Gene Expression Profiles in the Adipose Tissue of Obese Adult Mice with Rapid Infantile Growth after Undernourishment In Utero Reviewed

Suzuki M, Kohmura-Kobayashi Y, Ueda M, Furuta-Isomura N, Matsumoto M, Oda T, Kawai K, Itoh T, Matsuya M, Narumi M, Tamura N, Uchida T, Mochizuki K, Itoh H.

Frontiers in Endocrinology   2022.2( ISSN：1664-2392 )

発達期環境によるサイトカインストーム形成と動脈硬化関連疾患発症との関連“Relationship between cytokine storm triggered by environments during developing stages and arteriosclerosis-related diseases”

石山詩織，岸上哲士, 望月和樹.

BIO Clinica   2021.12

Development of the diabetic kidney disease mouse model culturing embryos in α-minimum essential medium in vitro, and feeding barley diet attenuated the pathology Reviewed

Ishiyama S., Kimura M,, Nakagawa T., Uchimura K., Fujimoto Y., Kishigami S., and Mochizuki K.

Frontiers in Endocrinology   2021.11( ISSN：1664-2392 )

Effects of barley intake on glycemic control in Japanese patients with type 2 diabetes mellitus undergoing antidiabetic therapy: a prospective study. Reviewed

Osonoi T, Matsuoka T, Ofuchi K, Katoh M, Kobayashi K, Mochizuki K

Diabetology International   2021.10

松本沙知, 石山詩織，望月和樹，岸上哲士.

着床前胚の体外培養とその長期影響～挑戦と課題、そして応用～“Embryo culture and long-term consequences: challenges, new issues, and applications”

動物細胞培養における培地と培養系の工夫 ～技術と市場～   2021.10

Effects of barley intake on glycemic control in Japanese patients with type 2 diabetes mellitus undergoing antidiabetic therapy: a prospective study. Reviewed

Osonoi T, Matsuoka T, Ofuchi K, Katoh M, Kobayashi K, Mochizuki K

None   2021.10

Consumption of barley ameliorates the diabetic steatohepatitis and reduces the high transforming growth factor β expression in mice grown in α-minimum essential medium in vitro as embryos. Reviewed

Ishiyama S, Kimura M , Umihira N , Matsumoto S, Takahashi A, Nakagawa T, Wakayama T, Kishigami S, Mochizuki K.

None   2021.9

Regulation of Carbohydrate-Responsive Metabolic Genes by Histone Acetylation and the Acetylated Histone Reader BRD4 in the Gene Body Region Reviewed

Mochizuki K, Ishiyama S, Hariya N, Goda T.

Frontiers in Molecular Biosciences   2021.7

Feeding Rats Medium-Chain Triglycerides and Tomato Powder Increases Liver Lycopene Content and Reduces the Expression of Genes Related to Lipid Metabolism in the Liver. Reviewed

Kimura M, Tamura S, Ishiyama S, and Mochizuki K.

None   2021.7( ISSN：2692-1944 )

S100 Genes Are Highly Expressed in Peripheral Leukocytes of T2DM Patients Treated with Dietary Therapy Reviewed

Kondo S, Mochizuki K, Hariya N, Saito M, Doguchi S, Osonoi T.

DRUGS IN R&D   2021.3( ISSN：1174-5886 )

Induction of HOX genes by HCV infection via impairment of histone H2A monoubiquitination. Reviewed

Kasai H, Mochizuki K, Tanaka T, Yamashita A, Matsuura Y, and Moriishi K

JOURNAL OF VIROLOGY   2021.2( ISSN：0022-538X )

Mice derived from in vitro-αMEM cultured preimplantation embryos exhibit postprandial hyperglycemia and higher inflammatory gene expression in peripheral leukocytes. Reviewed

Ishiyama S, Kimura M , Umihira N , Matsumoto S, Takahashi A, Nakagawa T, Wakayama T, Kishigami S, Mochizuki K.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   2021.2( ISSN：0916-8451 )

Bromodomain-containing protein 4 regulates a cascade of lipid-accumulation-related genes at the transcriptional level in the 3T3-L1 white adipocyte-like cell line Reviewed

Mochizuki K, Yamada M, Inoue T, Hariya N, Kubota T, Goda T

EUROPEAN JOURNAL OF PHARMACOLOGY   883   173351   2020.9( ISSN：0014-2999 )

Glucose and TNF enhance expression of TNF and IL1B, and histone H3 acetylation and K4/K36 methylation, in juvenile macrophage cells Reviewed

Gene   5   100034   2020.4

Excessive folic acid supplementation in pregnant mice impairs insulin secretion and induces the expression of genes associated with fatty liver in their offspring. Invited Reviewed

Kintaka Y, Wada N, Shioda S, Nakamura S, Yamazaki Y, Mochizuki K

Heliyon   6 ( 4 )   e03597   2020.4

Consumption of a meal containing refined barley flour bread is associated with a lower postprandial blood glucose concentration after a second meal compared with one containing refined wheat flour bread in healthy Japanese: A randomized control trial Reviewed

Matsuoka T, Tsuchida A, Yamaji A, Kurosawa C, Shinohara M, Takayama I, Nakagomi H, Izumi K, Ichikawa Y, Hariya N, Yamashita S, Mochizuki K.

NUTRITION   72   110637   2020.4( ISSN：0899-9007 )

Undernutrition in Pregnant Rats Induces Glucose Intolerance with Enhanced Expression of Inflammation-Related Genes in Peripheral Leukocytes of the Offspring.

Jin F, Honma K, Mochizuki K, Goda T.

J Nutr Sci Vitaminol (Tokyo).   65 ( 6 )   534 - 540   2019.12

Epigenetic regulation of lipoprotein lipase gene via BRD4, which is potentially associated with adipocyte differentiation and insulin resistance. Reviewed

Inoue T, Hariya N, Imamochi Y, Dey A, Ozato K, Goda T, Kubota T, Mochizuki K.

EUROPEAN JOURNAL OF PHARMACOLOGY   858   172492   2019.6( ISSN：0014-2999 )

DOHaD―次世代の健康を守る科学―　

久保田健夫、望月和樹

小児科臨床　   72 ( 4 )   2019.4

Supplementation with lower doses of EGCg reduces liver injury markers of type 2 diabetic rats. Reviewed

Mochizuki K, Tan Y, Uchiyama Y, Suzuki T, Hariya N, Goda T.

Fundam. Toxicol. Sci.   6 ( 1 )   15 - 23   2019.2( ISSN：2189-115X )

Takeo Kubota, Kazuki Mochizuki Importance of early educational intervention for children based on reversibility of environmental stress-induced epigenetic alterations. Regional “Stress and Behavior”

ISBS Conference”   1   2019.1

Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis. Reviewed

Urmi JF, Itoh H, Muramatsu-Kato K, Kohmura-Kobayashi Y, Hariya N, Jain D, Tamura N, Uchida T, Suzuki K, Ogawa Y, Shiraki N, Mochizuki K, Kubota T, Kanayama N.

Scientific Reports   9 ( 1 )   17100   2019( ISSN：2045-2322 )

High-dose β-carotene exacerbates high-fat/high-sucrose diet-inducible fibrosis in the liver of Mongolian gerbils Reviewed

Kondo S, Hariya N, Mochizuki K.

Fundam. Toxicol. Sci.   6   235 - 243   2019

The induction of CHD1 binding and methylation histone H3 K4 methylation on SI gene is associated with the gene expression in enterocyte-like Caco-2 cells. Reviewed

Mochizuki K, Osaki A, Inamochi Y, Goda T.

OBM Genetics   2 ( 4 )   2018.10( ISSN：2577-5790 )

エネルギー産生回路とエピジェネティックスを介した中鎖脂肪の代謝改善作用オレオサイエンス

望月 和樹、木村 真由、川村 武蔵、針谷 夏代、合田 敏尚

オレオサイエンス   18 ( 8 )   375 - 382   2018.8

Novel models of epigenetic gene regulation in the nutritional environment. Developmental Origins of Health and Disease (DOHaD):

Mochizuki K, Hariya N, Kubota T.

From Biological Basis to Clinical Significance in Advances in Experimental Medicine and Biology.   11 - 18   2018.7

Regulation of the circadian rhythmic expression of Sglt1 in the mouse small intestine through histone acetylation and the mRNA elongation factor, BRD4-P-TEFb. Reviewed

Yamauchi H, Honma K, Mochizuki K, Goda T.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   2018.3( ISSN：0916-8451 )

神経系のエピゲノム研究 Reviewed

久保田健夫、望月和樹

CLINICAL NEUROSCIENCE   36 ( 2 )   168 - 171   2018.2( ISSN：0289-0585 )

The roles of epigenetics in developmental programming/Developmental Origins of Health and Disease theory. Reviewed

Mochizuki K, Imai C, Sato N, Kubota T.

1 ( 4 )   2017.10

BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene. Reviewed

Sakurai N, Inamochi Y, Inoue T, Hariya N, Kawamura M, Yamada M, Dey A, Nishiyama A, Kubota T, Ozato K, Goda T, Mochizuki K

Scientific Reports   7 ( 1 )   11962   2017.9( ISSN：2045-2322 )

早期環境が健康に影響するメカニズム

久保田健夫、望月和樹

医学ジャーナル   53 ( 9 )   71 - 75   2017.9

Insulin-induced inhibition of gluconeogenesis genes, including glutamic pyruvic transaminase 2, is associated with reduced histone acetylation in a human liver cell line. Reviewed

Honma K, Kamikubo M, Mochizuki K, Goda T.

METABOLISM-CLINICAL AND EXPERIMENTAL   71   118 - 124   2017.7( ISSN：0026-0495 )

Carbohydrate-Responsive Histone Acetylation in Gene Body Regions: Carbohydrate-Inducible Histone Acetylation

Kazuki Mochizuki, Natsuyo Hariya, Kazue Honma,Toshinao Goda

Handbook of Nutrition, Diet, and Epigenetics   2017.7

Effects of Nutrients Involved in Neurodevelopmental and Mental Disorders.

Kubota T, Mochizuki K

Handbook of Nutrition, Diet, and Epigenetics (Springer)   2017.7

Relationship between epigenetic regulation, dietary habits, and the Developmental Origins of Health and Disease theory. Reviewed

Mochizuki K, Hariya N, Honma K, Goda T

CONGENITAL ANOMALIES   2017.2( ISSN：0914-3505 )

BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver Reviewed

Yamada A, Honma K, Mochizuki K, Goda T

METABOLISM-CLINICAL AND EXPERIMENTAL   65 ( 10 )   1478 - 1488   2016.10( ISSN：0026-0495 )

Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression. Reviewed

Inamochi Y, Dey A, Nishiyama A, Kubota T, Ozato K, Goda T, Mochizuki K

Biochem Biophys Rep   7   150 - 156   2016.9( ISSN：2405-5808 )

Add-on therapy with anagliptin in Japanese patients with type-2 diabetes mellitus treated with metformin and miglitol can maintain higher concentrations of biologically active GLP-1/total GIP and a lower concentration of leptin.

Osonoi T, Saito M, Hariya N, Goto M, Mochizuki K.

PEPTIDES   86   118 - 125   2016( ISSN：0196-9781 )

Epigenetic Effect of Environmental Factors on Autism Spectrum Disorders

Kubota T, Mochizuki K.

Int J Environ Res Public Health   14 ( 13(5) )   1 - 12   2016( ISSN：1661-7827 )

Fasting during the suckling-weaning transient period of rats induces inflammatory gene expression in the adipose tissue and peripheral leukocytes Reviewed

Honma K, Mawatari R, Iikeda M, Mochizuki K, and Goda T.

NUTRITION   32 ( 11-12 )   1268 - 1274   2016( ISSN：0899-9007 )

Glycemic Response in Healthy Japanese Subjects after Consuming Potatoes and White Rice. Reviewed

Wakasugi Y, Hashidume S, Sano A, Mochizuki K, Goda T, Ichikawa Y

Journal of ARAHE   23 ( 1 )   2016( ISSN：2234-4454 )

Prader-Willi syndrome: the disease that opened up epigenomic-based preemptive medicine. Invited Reviewed

Kubota T, Miyake K, Hariya N, Nguyen Quoc VT, Mochizuki K.

Diseases   4 ( 1 )   15   2016( ISSN：2079-9721 )

Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver. Reviewed

Honma K, Hikosaka M, Mochizuki K, Goda T

METABOLISM-CLINICAL AND EXPERIMENTAL   65 ( 4 )   482 - 491   2016( ISSN：0026-0495 )

Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Reviewed

Ikeda M, Honma K, Mochizuki K, and Goda T.

EUROPEAN JOURNAL OF NUTRITION   55 ( 3 )   1059 - 1067   2016( ISSN：1436-6207 )

Morphological, biochemical, transcriptional and epigenetic responses to fasting and refeeding in intestine of Xenopus laevis. Reviewed

Tamaoki K, Okada R, Ishihara A, Shiojiri N, Mochizuki K, Goda T and Yamauchi K

Cell and Bioscience   6 ( 2 )   2016( ISSN：2045-3701 )

Gene body領域のエピゲノム修飾に基づいた代謝関連遺伝子の発現制御機構

望月和樹, 針谷夏代, 本間一江, 合田敏尚, 久保田健夫

BIO Clinica   30 ( 9 )   903 - 908   2015.12

Inhibition of postprandial hyperglycemia by either an insulin-dependent or -independent drug reduces the expression of genes related to inflammation in peripheral leukocytes of OLETF rats.

Imai C, Harazaki T, Inoue S, Mochizuki K, Goda T.

Biosci Biotechnol Biochem.   77 ( 11 )   2305 - 2308   2015

Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients.

Tamasawa A, Mochizuki K, Hariya N, Saito M, Ishida H, Doguchi S, Yanagiya S, Osonoi T.

Eur J Pharmacol.   762   96 - 101   2015

Treatment with DPP-4I anagliptin or α-GI miglitol reduces IGT development and the expression of CVD risk factors in OLETF rats. Reviewed

Imai C, Harazaki T, Inoue S, Mochizuki K and Goda T.

J Nutr Sci Vitaminol (Tokyo).   61 ( 4 )   313 - 321   2015

Serum fatty acid binding protein 4 concentrations are positively and independently associated with blood preｗssure and abdominal fat among parameters in health check-ups in middle-aged general Japanese males. Reviewed

Yamada M, Mochizuki K, Honma K, Miyauchi R, Kasezawa N, Tohyama K and Goda T.

J Nutr Sci Vitaminol (Tokyo).   61 ( 4 )   291 - 298   2015

Plasma TNF-α is associated with inflammation and nutrition status in community-dwelling Japanese elderly. Reviewed

OE Y, Mochizuki K, Miyauchi R, Misaki Y, Kasezawa N, Tohyama K,Goda T.

J Nutr Sci Vitaminol (Tokyo).   61 ( 3 )   263 - 269   2015

ChREBP binding and histone modifications modulate hepatic expression of the Fasn gene in a metabolic syndrome rat model. Reviewed

Suzuki T, Muramatsu T, Morioka K, Goda T, Mochizuki K.

Nutrition   31 ( 6 )   877 - 883   2015

望月和樹、久保田健夫

DOHaDとエピジェネティクス   88   2015

胎生期プログラミングとエピジェネティックス

望月和樹

最新医学   70 ( 5 )   867 - 874   2015

先制医療と生物学的基盤としてのエピジェネティックス

久保田健夫、三宅邦夫、針谷夏代、望月和樹　

実験医学　増刊「先制医療 実現のための医学研究」   33 ( 7 )   1043 - 1048   2015

Epigenomic-basis of Preemptive Medicine for Neurodevelopmental Disorders. Reviewed

Kubota T, Miyake K, Hariya N and Mochizuki K.

Current Genomics   6 ( 2 )   96 - 104   2015

Understanding the epigenetics of neurodevelopmental disorders and DOHaD.

Kubota T, Miyake K, Hariya N and Mochizuki K.

J Dev Orig Health Dis.   6 ( 2 )   96 - 104   2015

Maternal restraint stress during pregnancy in mice induces 11β-HSD1–associated metabolic changes in the livers of the offspring. Reviewed

Maeyama H, Hirasawa T, Tahara Y, Obata C, Kasai H, Moriishi K, Mochizuki K, and Kubota T.

J Dev Orig Health Dis.   6 ( 2 )   105 - 114   2015

Long-term imipramine treatment increases N-methyl-D-aspartate receptor activity and expression via epigenetic mechanisms.

Nghia N. A, Hirasawa T, Kasai H, Obata C, Moriishi K, Mochizuki K, Koizumi S, and Kubota T.

Eur J Pharmacol.   752   69 - 77   2015

Putative PPAR target genes express highly in skeletal muscle of insulin-resistant MetS model SHR/NDmc-cp rats. Reviewed

Hariya N, Miyake K, Kubota T, Goda T, Mochizuki K.

J Nutr Sci Vitaminol (Tokyo).   61 ( 1 )   28 - 36   2015

Induction of histone H3K4 methylation at the promoter, enhancer, and transcribed regions of the SI and SGLT1 genes in rat jejunum in response to a high-starch/low-fat diet.

Inoue S, Honma K, Mochizuki K and Goda T.

Nutrition.   31 ( 2 )   366 - 372   2015

環境エピジェネティックス変化と疾患

久保田健夫、三宅邦夫、針谷夏代、望月和樹

生体の化学   65 ( 6 )   547 - 552   2015

Self-reported faster eating is positively associated with accumulation of visceral fat in middle-aged apparently healthy Japanese men.

Mochizuki K, Yamada M, Miyauchi R, Misaki Y, Kasezawa N, Tohyama K, Goda T.

Eur J Nutr.   53 ( 5 )   1187 - 1194   2014

Switching α-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese Patients.

Hariya N, Mochizuki K, Inoue S, Saito M, Fuchigami M, Goda T, Osonoi T.

Drugs R. D.   14 ( 3 )   177 - 184   2014

Thyroid and glucocorticoid hormones induce expression of lactase-phlorizin hydrolase gene in CDX-2/HNF-1α co-transfected IEC-6 cells.

Suzuki T, Mochizuki K and Goda T.

J Nutr Sci Vitaminol (Tokyo).   60 ( 5 )   321 - 327   2014

Epigenetics as a basis for diagnosis of neurodevelopmental disorders: challenges and opportunities.

Kubota T, Miyake K, Hariya N, Mochizuki K.　

Expert Rev Mol Diagn.   14 ( 6 )   685 - 697   2014

Bindings of ChREBP and SREBP1, and histone acetylation around the rat liver fatty acid synthase gene are associated with induction of the gene during the suckling-weaning transition.

Morishita S, Mochizuki K, Goda T.

J Nutr Sci Vitaminol (Tokyo).   60 ( 2 )   94 - 100   2014

Re-feeding rats a high-sucrose diet after 3 days of starvation enhances histone H3 acetylation in transcribed region and expression of jejunal GLUT5 gene.

Honma K, Masuda Y, Mochizuki K, and Goda T.

Biosci. Biotechnol. Biochem.   78 ( 6 )   1071 - 1073   2014

Insulin Resistance in SHR/NDmc-cp Rats Correlates with Enlarged Perivascular Adipocytes and Endothelial Cell Dysfunction in Skeletal Muscle.

Hariya N, Mochizuki K, Inoue S, Morioka K, Shimada M, Okuda T, Goda T.

J Nutr Sci Vitaminol (Tokyo).   60 ( 1 )   52 - 59   2014

Cotreatment with the α-glucosidase inhibitor miglitol and DPP-4 inhibitor sitagliptin improves glycemic control and reduces the expressions of CVD risk factors in type 2 diabetic Japanese patients.　

Imai C, Saito M, Mochizuki K, Fuchigami M, Goda T, Osonoi T.

Metabolism.   63 ( 3 )   746 - 753   2014

Resistant starch improves insulin resistance and reduces adipose tissue weight and CD11c expression in rat OLETF adipose tissue.

Harazaki T, Inoue S, Imai C, Mochizuki K, Goda T.

Nutrition.   30 ( 5 )   590 - 595   2014

Histone code of genes induced by co-treatment with a glucocorticoid hormone agonist and a p44/42 MAPK inhibitor in human small intestinal Caco-2 cells.

Inamochi Y, Mochizuki K, Goda T.

Biochim. Biophys. Acta. General subjects   1840 ( 1 )   693 - 700   2014

Self-reported faster eating associated with higher ALT activity in middle-aged, apparently healthy Japanese women.

Mochizuki K, Hariya N, Miyauchi R, Misaki Y, Ichikawa Y, Goda T.

Nutrition.   30 ( 1 )   69 - 74   2014

Serum γ-GTP activity is closely associated with serum CRP levels in non-overweight and overweight middle-aged Japanese men.

Sunto A, Mochizuki K, Miyauchi R, Misaki Y, Shimada M, Kasezawa N, Tohyama K, Goda T.

J Nutr Sci Vitaminol (Tokyo).   59 ( 2 )   108 - 114   2013

生活習慣病患者を対象としたγ-GTPに影響を与える因子の検討

駿藤晶子、中村丁次、倉貫早智、望月和樹、千場純、合田敏尚

New Diet Therapy.　日本臨床栄養協会   19 ( 1 )   3 - 9   2013

Dietary supplementation with a low dose of (-)-epigallocatechin-3-gallate reduces pro-inflammatory responses in peripheral leukocytes of non-obese type 2 diabetic GK rats.　

Uchiyama Y, Suzuki T, Mochizuki K, Goda T.

J Nutr Sci Vitaminol (Tokyo).   59 ( 6 )   541 - 547   2013

Circulating interleukin-1β concentrations are independently-positively associated with γ-glutamyltransferase activity within the normal range in middle-aged apparently healthy Japanese women.

Yamazaki J, Mochizuki K, Miyauchi R, Ichikawa Y, Goda T.　

J Nutr Sci Vitaminol (Tokyo).   59 ( 6 )   526 - 532   2013

Plasma sE-selectin level is positively correlated with neutrophil count and diastolic blood pressure in Japanese men.

Mochizuki K, Inoue S, Miyauchi R, Misaki Y, Shimada M, Kasezawa N, Tohyama K, Goda T.

J Nutr Sci Vitaminol (Tokyo).   59 ( 5 )   447 - 453   2013

Dietary supplementation with (-)-epigallocatechin-3-gallate reduces inflammatory response in adipose tissue of non-obese type 2 diabetic Goto-Kakizaki (GK) rats.

Uchiyama Y, Suzuki T, Mochizuki K, Goda T.

J Agric Food Chem.   61 ( 47 )   11410 - 11417   2013

Fructose force-feeding induces histone H3 and H4 acetylation at their lysine residues around the Slc2a5 gene and induces its expression in mice.

Honma K, Mochizuki K, and Goda T.

Biosci. Biotechnol. Biochem.   77 ( 11 )   2188 - 2191   2013

Methylation of histone H3 at lysine 4 and expression of the maltase-glucoamylase gene are reduced by dietary resistant starch.

Shimada M, Mochizuki K, Goda T.

J Nutr Biochem.   24 ( 3 )   606 - 612   2013

Principal component 1 score calculated from metabolic syndrome diagnostic parameters is a possible marker for the development of metabolic syndrome in middle-aged Japanese men without treatment for metabolic diseases.

Mochizuki K, Miyauchi R, Misaki Y, Ichikawa Y, Goda T.

Eur J Nutr.   52 ( 1 )   67 - 74   2013

Mochizuki K, Ishihara A, Goda T, Yamauchi K. Reviewed

RNA polymerase II phosphorylation at serine 2 and histone H3 tri-methylation at lysine 36 are key steps for thyroid hormone receptor ß gene activation by thyroid hormone in Rana catesbeiana tadpole liver.

Biochem. Biophys. Res. Commun.   417 ( 3 )   1069 - 1073   2012

Induction of the BCMO1 gene during the suckling-weaning transition in rats is associated with histone H3 K4 methylation and subsequent coactivator binding and histone H3 acetylation to the gene.

Mochizuki H, Mochizuki K, Suruga K, Igarashi M, Takase S, Goda T.

J Nutr Sci Vitaminol (Tokyo).   58 ( 5 )   319 - 326   2012

Gene expression profile in the liver of Rana catesbeiana tadpoles exposed to low temperature in the presence of thyroid hormone.

Mochizuki K, Goda T, Yamauchi K.

Biochem. Biophys. Res. Commun.   420 ( 4 )   845 - 850   2012

Associations between leukocyte counts and cardiovascular disease risk factors in apparently healthy Japanese men. Reviewed

Mochizuki K, Miyauchi R, Misaki Y, Kasezawa N, Tohyama K and Goda T.

J. Nutr. Sci. Vitaminol   58 ( 3 )   181 - 186   2012

Mochizuki K, Misaki Y, Miyauchi R, Takabe S, Shimada M, Kuriki K, Ichikawa Y and Goda T. Reviewed

A higher rate of eating is associated with higher circulating IL-1β concentrations in Japanese men without treatment for metabolic diseases.

Nutrition   28 ( 10 )   978 - 983   2012

Yoshinaga Y, Mochizuki K, Goda T. Reviewed

Trimethylation of histone H3K4 is associated with the induction of fructose-inducible genes in rat jejunum.

Biochem. Biophys. Res. Commun.   419 ( 4 )   605 - 611   2012

Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate:Participation of reversible covalent binding for interaction and stabilization. Reviewed

Ishii　T, Ichikawa　T, Minoda K, Kusaka K, Ito S, Suzuki Y, Akagwa M, Mochizuki K, Goda T, and Nakayama T.

Biosci. Biotechnol. Biochem.   75 ( 1 )   100 - 106   2011

Associations between markers of liver injury and cytokine markers for insulin sensitivity and inflammation in middle-aged Japanese men not being treated for metabolic diseases. Reviewed

Mochizuki K, Misaki Y, Miyauchi R, Takabe S, Shimada M, Ichikawa Y, Goda T.

J. Nutr. Sci. Vitaminol.   57 ( 1 )   65 - 73   2011

Treatment with the α-glucosidase inhibitor miglitol from the preonset stage in Otsuka Long-Evans Tokushima Fatty rats improves glycemic control and reduces the expression of inflammatory cytokine genes in peripheral leukocytes. Reviewed

Mochizuki K, Fukaya N, Tanaka Y, Fuchigami M, Goda T.

Metabolism.   60 ( 11 )   1560 - 1565   2011

Accumulation of visceral fat is positively associated with serum ALT and γ-GTP activities in healthy and preclinical middle-aged Japanese men. Reviewed

Mochizuki K, Miyauchi R, Misaki Y, Shimada M, Kasezawa T, Tohyama K, Goda T.

J. Nutr. Sci. Vitaminol.   57 ( 1 )   65 - 73   2011

Circulating interleukin-1β and interleukin-6 concentrations are closely associated with γ-glutamyltranspeptidase activity in middle-aged Japanese men without obvious cardiovascular diseases. . Reviewed

Mochizuki K, Misaki Y, Miyauchi R, Takabe S, Shimada M, Miyoshi N, Ichikawa Y, Goda T.

Metabolism.   60 ( 7 )   914 - 922   2011

ミグリトールまたはシダグリプチン単独による治療で効果不十分な2型糖尿病患者における両剤併用療法の効果

遅野井健、斎藤三代子、望月和樹、今井千裕、合田敏尚.

診断と新薬   48 ( 5 )   11 - 22   2011

Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions. Reviewed

Iwashina I, Mochizuki K, Inamochi Y, Goda T.

J. Nutr. Biochem.   22 ( 4 )   334 - 343   2011

Suzuki T, Douard V, Mochizuki K, Goda T, Ferraris R. Reviewed

Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter GLUT5 during development of rat small intestine.

Biochem J.   435 ( 1 )   43 - 53   2011

Jejunal induction of SI and SGLT1 genes in rats by high-starch/low-fat diet is associated with histone acetylation and binding of GCN5 on the genes.

Inoue　S, Mochizuki K, Goda T.

J. Nutr. Sci. Vitaminol.   57 ( 2 )   162 - 169   2011

Feeding rats dietary resistant starch reduces both the binding of ChREBP and the acetylation of histones on the Thrsp Gene in the Jejunum. Reviewed

Shimada M, Mochizuki K, Goda T.

J. Agric. Food. Chem.   59 ( 4 )   1464 - 1469   2011

Evaluation of weight loss in the community-dwelling elderly with dementia as assessed by eating behavior and mental status.

Miyamoto K, Higashino S, Mochizuki K, Goda T,Koyama H.

Asia. Pac. J. Clin. Nutr.   20 ( 1 )   9 - 13   2011

In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice. Reviewed

Fujimoto S, Goda T, Mochizuki K.

Biochem. Biophys. Res. Commun.   404 ( 1 )   223 - 227   2011

β-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-α. Reviewed

Kameji H, Mochizuki K, Miyoshi N, Goda T.

Nutrition.   26 ( 11-12 )   1151 - 1156   2010

Reduced expression of β2 integrin genes in rat peripheral leukocytes by inhibiting postprandial hyperglycemia. Reviewed

Mochizuki K, Shimada M, Tanaka Y, Fukaya N, Goda T.

Biosci. Biotechnol. Biochem.   74 ( 12 )   2470 - 2474   2010

The regulation of jejunal induction of the maltase-glucoamylase gene by a high starch/low fat-diet in mice. Reviewed

Mochizuki K, Honma K, Shimada M, Goda T.

Mol. Nutr. Food Res.   54 ( 10 )   1445 - 1451   2010

Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the α-glucosidase inhibitor miglitol. Reviewed

Mochizuki K, Hanai E, Suruga K, Kuranuki, S., Goda, T.

Metabolism.   59   1442 - 1447   2010

Changes in mucosal α-glucosidase activities along the jejunal–ileal axis by an hm-HACS diet intake are associated with decreased lipogenic enzyme activity in epididymal adipose tissue. Reviewed

Mochizuki K, Sato Y, Takase S, Goda T.

J. Agric. Food. Chem.   58   6923 - 6927   2010

Feeding rats a high fat/carbohydrate ratio diet reduces jejunal S/I activity ratio and unsialylated galactose on glycosylated chain of S-I complex. Reviewed

Mochizuki K, Igawa-Tada M, Takase S, Goda T.

Life Sci.   86   524 - 531   2010

Insulin resistance induced by a high-fat diet is associated with induction of genes related to leukocyte activation in rat peripheral leukocytes. Reviewed

Fujimoto S, Mochizuki K, Shimada M, Hori T, Murayama Y, Ohashi N, and Goda T.

Life Sci.   87   679 - 685   2010

The α-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes. Reviewed

Osonoi T, Saito M, Mochizuki K, Fukaya N, Muramatsu T, Inoue S, Fuchigami M, Goda T.

Metabolism.   59 ( 2 )   1816 - 1822   2010

Gene expression of inflammatory cytokines in peripheral leukocytes in db/db mice is elevated as progression of diabetes. Reviewed

Fujimoto S, Mochizuki K, Shimada M, Murayama Y, Goda T.

Biosci. Biotechnol. Biochem.   74 ( 7 )   1488 - 1490   2010

Plasma IL-1β concentrations are closely associated with fasting blood glucose levels in healthy and preclinical middle-aged, non-overweight and overweight Japanese men. Reviewed

Misaki Y, Miyauchi R, Mochizuki K, Takabe S, Shimada M, Ichikawa Y, Goda T.

Metabolism.   59   1465 - 1471   2010

Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression. Reviewed

Inamochi Y, Mochizuki K, Osaki A, Ishii T, Nakayama T, Goda T.

Biochem. Biophys. Res. Commun.   392 ( 1 )   16 - 21   2010

Effects of wheat albumin consumption on expression of genes related to lipogenesis and insulin sensitivity in adipose tissues of rats. Reviewed

Murayama Y, Mochizuki K, Shimada M, Matsuoka Y, Shibata K, Goda T.

J. Agric. Food. Chem.   57   1606 - 1611   2009

Gene expression changes in the jejunum of rats during the transient suckling-weaning period. Reviewed

Mochizuki K, Yorita S, Goda T.

J. Nutr. Sci. Vitaminol. (Tokyo)   55   139 - 148   2009

クロマチンリモデリング因子による小腸吸収細胞遺伝子発現誘導機構(平成21年度日本栄養・食糧学会奨励賞) 　

望月和樹

日本栄養食糧学会誌   62   281 - 290   2009

The α-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic β-cells in OLETF rats. Reviewed

Fukaya N, Mochizuki K, Tanaka Y, Kumazawa T, Jiuxin Z, Fuchigami M, Goda T.

Eur. J. Pharmacol.   624 ( 1-3 )   51 - 57   2009

Dietary resistant starch reduces histone acetylation on the glucose-dependent insulinotropic polypeptide gene in the jejunum. Reviewed

Shimada M, Mochizuki K, Goda T.

Biosci. Biotechnol. Biochem.   73   2754 - 2757   2009

Dietary supplementation with α-amylase inhibitor wheat albumin to high-fat diet-induced insulin-resistant rats is associated with increased expression of genes related to fatty acid synthesis in adipose tissue. Reviewed

Murayama Y, Mochizuki K, Shimada M, Fujimoto S, Nukui K, Shibata, K., Goda, T.

J. Agric. Food. Chem.   57   9332 - 9338   2009

Localized expression of genes related to carbohydrate and lipid absorption along the crypt-villus axis of rat jejunum. Reviewed

Suzuki T, Mochizuki K, Goda T.

Biochim. Biophys. Acta.   1790 ( 12 )   1624 - 1635   2009

Feeding rats dietary resistant starch shifts the peak of SGLT1 gene expression and histone H3 acetylation on the gene from the upper jejunum toward the ileum. Reviewed

Shimada M, Mochizuki K, Goda T.

J. Agric. Food. Chem.   57   8049 - 8055   2009

Induction of histone acetylation on the sucrase-isomaltase gene in the postnatal rat jejunum. Reviewed

Yorita S, Mochizuki K, Goda T.

Biosci. Biotechnol. Biochem.   73   933 - 935   2009

The α-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of inflammatory cytokines induced by hyperglycemia in peripheral leukocytes.

Fukaya N, Mochizuki K, Shimada M, Goda T.

Nutrition.   25 ( 65 )   657 - 667   2009

Modifications of histone H3 at lysine 9 on the adiponectin gene in 3T3-L1 adipocytes.

Sakurai N, Mochizuki K, Goda Y.

J. Nutr. Sci. Vitaminol. (Tokyo)   55   131 - 138   2009

(-)-Epigallocatechin gallate enhances the expression of genes related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation. Reviewed

Sakurai N, Mochizuki K, Kameji H, Shimada S, Goda T.

Nutrition   10   1047 - 1056   2009

The α-glucosidase inhibitor miglitol suppresses postprandial hyperglycemia and IL-1β and TNF-α gene expression induced by intermittent sucrose loading in rat peripheral leukocytes. Reviewed

Tanaka Y, Mochizuki K, Fukaya N, Shimada M, Goda T.

Br. J. Nutr.   102   221 - 225   2009

Intracellular delivery of acetyl-histone peptides inhibits native bromodomain-chromatin interactions and impairs mitotic progression. Reviewed

Nishiyama A, Mochizuki K, Mueller F, Karpova T, McNally JG, Ozato K.

FEBS. Lett.   582   1501 - 1507   2008

PPARα and PPARδ transactivity and p300 binding activity induced by arachidonic acid in colorectal cancer cell line Caco-2. Reviewed

Mochizuki K, Suzuki T, Goda T.

J. Nutr. Sci. Vitaminol. (Tokyo).   54   298 - 302   2008

The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase. Reviewed

Mochizuki K, Nishiyama A, Jang MK, Dey A, Ghosh A, Tamura T, Natsume H, Yao H, Ozato K.

J. Biol. Chem.   283 ( 14 )   9040 - 9048   2008

Possible role of fatty acids in milk as the regulator of the expression of cytosolic binding proteins for fatty acid and vitamin A through PPARα in developing rats. Reviewed

Mochizuki K, Mochizuki H, Kawai H, Ogura Y, Takase S, Shimada M, Goda T.

J. Nutr. Sci. Vitaminol.   53   515 - 521   2008

Changes of histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone. Reviewed

Mochizuki K, Takabe S, Goda T.

Biochem. Biophys. Res. Commun.   371   324 - 327   2008

Fatty acids in component of milk enhance the expression of the CBP/p300 gene in developing rats. Reviewed

Mochizuki K, Kawai H, Mochizuki H, Shimada M, Takase S, Goda T.

Br. J. Nutr.   99   481 - 486   2008

Acute induction of histone acetylation on the jejunal sucrase–isomaltase gene by dietary fructose. Reviewed

Honma K, Mochizuki K, Goda T.

Br. J. Nutr .   100   698 - 702   2008

Inductions of histone H3 acetylation at lysine 9 on SGLT1 gene and its expression by feeding mice a high carbohydrate/fat ratio diet. Reviewed

Honma K, Mochizuki K, Goda T.

Nutrition   25   40 - 44   2008

Variation in gene expression of inflammatory cytokines in leukocyte-derived cells of high-fat-diet-induced insulin-resistant rats. Reviewed

Fujimoto S, Mochizuki K, Shimada M, Murayama Y, Goda T.

Biosci. Biotechnol. Biochem.   72   2572 - 2579   2008

Dietary resistant starch reduces levels of glucose-dependent insulinotropic polypeptide mRNA along the jejunum-ileum in both normal and type 2 diabetic rats. Reviewed

Shimada M, Mochizuki K, Goda T.

Biosci. Biotechnol. Biochem.   72   2206 - 2209   2008

Distribution and dietary induction of cellular retinol-binding protein type II along the villus–crypt axis of rat jejunum. Reviewed

Ogura Y, Yasutake H, Mochizuki K, Yoshikawa S, Suruga K, Sugiyama H, Takase S, Goda T.

J. Nutr. Sci. Vitaminol.   54   130 - 135   2008

De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells. Reviewed

Takabe S, Mochizuki K, Goda T.

Arch. Biochem. Biophys.   475   1 - 6   2008

Histone H3 modifications and Cdx-2 binding to the sucrase-isomaltase (SI) gene is involved in induction of the gene in the transition from the crypt to villus in the small intestine of rats. Reviewed

Suzuki T, Mochizuki K, Goda T.

Biochem. Biophys. Res. Commun.   369   788 - 793   2008

Higher expression of jejunal LPH gene in rats fed the high-carbohydrate/low-fat diet compared with those fed the low-carbohydrate/high-fat diet is associated with in vitro binding of Cdx-2 in nuclear proteins to its promoter regions. Reviewed

Tanaka T, Suzuki A, Kuranuki S, Mochizuki K, Suruga K, Takase S, Goda T.

Life Sci.   83   122 - 127   2008

Improving search efficiency of incremental variable selection using second-order optimal Criterion. Knowledge-Based Intelligent Information and Engineering Systems. Reviewed

Saito K, Mutoh N, Ikeda T, Goda T, Mochizuki, K.

12th International Conference, Proceedings, Part III   5179   9 - 16   2008

The possible roles of homeobox protein, Cdx-2 for the expression of LPH gene during postnatal development. Reviewed

Kuranuki S, Mochizuki K, Tanaka T, Goda T.

Life Sci   80   795 - 799   2007

C2bbe1細胞におけるall-transおよび9-cisレチノイドの作用。 Reviewed

小倉有子、望月和樹、梶谷香奈子、駿河和仁、高瀬幸子、影近弘之、合田敏尚

ビタミン   81   483 - 488   2007

Induction of histone acetylation on the CRBPII gene in perinatal rat small intestine. Reviewed

Ogura Y, Mochizuki K, Goda T.

Biochim. Biophys. Acta.   1770   1289 - 1296   2007

Carbohydrate/fat ratio in the diet alters histone acetylation on the sucrase-isomaltase gene and its expression in mouse small intestine. Reviewed

Honma K, Mochizuki K, Goda T.

Biochem. Biophys. Res. Commu.   357   1124 - 1129   2007

Dietary supplementation with epigallocatechin gallate elevates the levels of circulating adiponectin in non-obese type 2 diabetic Goto-Kakizaki rats. Reviewed

Shimada M, Mochizuki K, and Goda T.

Biosci. Biotech. Biochem.   71   2979 - 2982   2007

De-phosphorylation of TRα-1 by p44/42 MAPK inhibition enhances T3-mediated GLUT5 gene expression in the intestinal cell line Caco-2 cells. Reviewed

Mochizuki K, Sakaguchi N, Takabe S. and Goda T.

Biochem. Biophys. Res. Commu.   359   979 - 984   2007

Triiodothyronine (T3) and fructose coordinately enhance the expression of GLUT5 gene in the small intestine of the weaning rats. Reviewed

Mochizuki K, Sakaguchi N, Goda T.

Biosci. Biotechnol. Biochem.   71   1345 - 1347   2007

The critical period for thyroid hormone responsiveness through thyroid hormone receptor isoform α-1 in the postnatal small intestine. Reviewed

Mochizuki K, Yagi R, Sakaguchi N, Mochizuki H, Takabe S, Kuranuki S, Suzuki T, Shimada M, Goda T.

Biochim. Biophys. Acta   1770   609 - 616   2007

人間ドック男性受診者におけるCTスキャン腹部皮下および内臓脂肪面積の増減と生活習慣の関連性。 Reviewed

加瀬澤信彦、遠山和成、島田昌也、望月和樹、合田敏尚

日本人間ドック学会誌 (In Japanese) （2007）.   22   6 - 13   2007

Effects of miglitol, an α-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. Reviewed

Goda T. Suruga K, Komori A, Kuranuki S, Mochizuki K, Makita Y, Kumazawa T.

Br. J. Nutr.   98   702 - 710   2007

The dietary sucrose enhances intestinal lactase gene expression in euthyroid rats. Reviewed

Kuranuki S, Mochizuki K, Goda T.

J. Nutr. Sci. Vitaminol.   52   347 - 351   2006

Selectivity of fatty acid ligands for PPARα which correlates both with binding to cis-element and DNA binding-independent transactivity in Caco-2 cells. Reviewed

Mochizuki K, Suruga K, Fukami H, Kiso Y, Takase S, Goda T.

Life Sci.   80   140 - 145   2006

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Reviewed

Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K.

Mol Cell.   19   523 - 534   2005

Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line, Caco-2. Reviewed

Mochizuki K, Suruga K, Takase S, Goda T.

Gene   291   271 - 277   2002

The expression of PPAR-associated genes is modulated through postnatal development of PPAR subtypes in the small intestine. Reviewed

Mochizuki K, Suruga K, Yagi E, Takase S, Goda T.

Biochim. Biophys. Acta   1531   68 - 76   2001

Modulation of the expression of PPAR-dependent genes through disproportional expression of two PPAR subtypes in the small intestine. Reviewed

Mochizuki K, Suruga K, Kitagawa M, Goda T, Takase S.

Arch. Biochem. Biophys.   389   41 - 48   2001

Transcriptional regulation of cellular retinol-binding protein, type II gene expression in small intestine by dietary fat. Reviewed

Suruga K, Mochizuki K, Kitagawa M, Goda T, Horie N, Takeishi K, and Takase S.

Arch. Biochem. Biophys.   362   159 - 166   1999

Regulation of cellular retinol-binding protein type II gene expression by arachidonic acid analogue and 9-cis retinoic acid in Caco-2 cells. Reviewed

Suruga K, Mochizuki K, Suzuki R, Goda T, Takase S.

Eur. J. Biochem.   262   70 - 78   1999

武川米農林48号の成分と食味との関連

原澤彩, 石山詩織, 小林勇太, 樋口かよ, 市川陽子, 望月和樹

日本食品科学工学会  2023.8 

大腸炎モデルSAMP6マウスへのフラクトオリゴ糖が与える代謝への影響

椿　孔仁、小笠原 佳弥、望月 和樹、石山 詩織

日本農芸化学会関東支部2023年度大会  2023.8 

胎生期タンパク質コリン低栄養が肝臓・脂肪組織の与える影響

岩﨑三奈、石山詩織、望月和樹

第11回日本DOHaD学会学術集会  2023.8 

早期離乳による脂肪肝発症と肝臓内リン脂質の変化との関連

足立 遥郁, 石山 詩織, 吉村 健太郎, 葛西 宏威, 望月 和樹

第11回日本DOHaD学会学術集会  2023.8 

Association between early weaning-inducible fatty liver and phosphatidylcholine molecule decreases in mouse liver International conference

Haruka Adachi, Shiori Ishiyama, Kentaro Yoshimura, Hirotake Kasai, Kazuki Mochizuki

IDF-WPR 2023/ 15th AASD  2023.7  DF-WPR 2023/ 15th AASD

キサンチンオキシダーゼ阻害剤による食後高血糖誘導性の脂肪合成経路の抑制

李 若源, 唐澤 花純, 石山 詩織, 望月 和樹

令和5年度 日本生化学会 関東支部例会  2023.6 

胎生期低タンパク質栄養に暴露されたマウスへの中鎖脂肪の投与が、筋 力や骨格筋構成関連遺伝子の発現に及ぼす影響

安彦 奈緒, 石山 詩織, 望月 和樹

令和5年度 日本生化学会 関東支部例会  2023.6 

小腸上皮様細胞へのフラクトオリゴ糖投与は炎症関連遺伝子の発現を増 大させ、腸内細菌非依存的に腸密着結合遺伝子の発現変化を誘導する。

原澤 彩, 石山 詩織, 望月 和樹

令和5年度 日本生化学会 関東支部例会  2023.6 

大学生を対象とした次世代の健康を包括した食教育基盤形成のための意識調査

今井 千裕、望月 和樹

第77回日本栄養・食糧学会大会  2023.5 

妊娠期の葉酸過剰摂取による仔の代謝性疾患発症誘導と消化管上皮細胞の形態学的変化との関連

金高 有里、和田 亘弘、奥田 明日香、田辺 賢一、望月 和樹、竹嶋 伸之輔、中村 禎子

第77回日本栄養・食糧学会大会  2023.5 

胎生期低タンパク質栄養に暴露されたマウスへの中鎖脂肪の投与が、筋力・代謝機能に及ぼす影響

安彦 奈緒、石山 詩織、望月 和樹

第77回日本栄養・食糧学会大会  2023.5 

フラクトオリゴ糖は腸内細菌非依存的に腸バリア機能関連遺伝子の発現を増大させる

原澤 彩、石山 詩織、望月 和樹

第77回日本栄養・食糧学会大会  2023.5 

大学生を対象とした次世代の健康を包括した食教育基盤形成のための意識調査

今井 千裕、望月 和樹

　第77回日本栄養・食糧学会大会  2023.5 

胚環境操作モデル脂肪肝炎MEMマウスにおけるヒストン修飾による脂肪滴

石山 詩織、中川 隆生、岸上 哲士、望月 和樹

第77回日本栄養・食糧学会大会   2023.5 

Excessive folic acid supplementation in pregnant mice induces glucose and lipid metabolic disorders in their offspring in infancy and/or adulthood. International conference

Kintaka　Y、Nakamura S、Wada N、Okuda A、Tanabe K、Mochizuki K、Oku T.

22nd IUNS-International Congress of Nutrition  2022.12 

Protein restriction during the fetal period upregulates IL1B and IL13 while suppressing MUC2 expression in the jejunum of mice after weaning International conference

Adachi H、Kudo M、Ishiyama S、Mochizuki K

2nd IUNS-International Congress of Nutrition  2022.12 

Relations between carbohydrate-responsive epigenetics and DOHaD Invited International conference

Mochizuki　K、Hariya N、Ishiyama S、Itoh H.

22nd IUNS-International Congress of Nutrition  2022.12 

胚発生初期２細胞期胚へのαMEM培地の曝露および出生後の高脂肪食投与は産仔の脂肪肝および糖尿病性腎症を誘導する Invited

石山詩織、中川隆生、内村幸平、岸上哲士、望月和樹

第95回日本生化学会大会  2022.11 

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山本裕昌 望月和樹

第9回 日本DOHaD学会　  2022.10 

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原澤彩、石山詩織、望月和樹

第9回 日本DOHaD学会  2022.10 

胎生期タンパク質制限が、出生後の 仔の腸バリア機能に与える影響

足立遥郁、工藤美芙由、石山詩織、望月和樹

第9回 日本DOHaD学会  2022.10 

中鎖脂肪とリコペン共投与が肝臓における糖・脂質代謝へ与える影響

早川 俳人、石山詩織、望月和樹

第12回機能油脂懇話会  2022.10 

胎生期タンパク質コリン低栄養マウスへのトマトパウダー投与が脂肪肝等の 代謝異常に与える影響

岩崎三奈、石山詩織、望月和樹　

第12回機能油脂懇話会  2022.10 

中鎖脂肪は、2 型糖尿病 NSY マウスの腎症の 進展を抑制する

萩原 麻衣、石山詩織、望月和樹

第 5 回中性脂肪学会学術集会  2022.10 

中鎖脂肪(MCT)はなぜ、太っていると体重を減らし、痩せている場合は. 低栄養を改善するのだろう？

望月和樹、石山詩織

第2回中性脂肪月間  2022.10 

健康な後期高齢者 32 名中 16 名で疑われた睡眠時無呼吸症候群と罹患予測の可能性

田中佑治、安藤隆、望月和樹、五十嵐賢、YHAB研究グループ

日本老年医学会  2022.6 

睡眠時無呼吸症候群の危険因子としてのロコモティブシンドローム-山梨健康長寿コホート Y-HALE study

安藤隆、田中佑治、望月和樹、YHAB研究グループ

日本整形外科学会総会  2022.5 

胎生期のタンパク質制限は、離乳後のマウスの空腸において、IL1B および IL13 の発現を 増大させ、MUC2 の発現を減少させる

足立遥郁、工藤美芙由、石山 詩織、望月 和樹

第76回日本栄養・食糧学会大会  2022.5 

ヒストンアセチル化修飾による脂肪滴蓄積遺伝子Cidea、CidecおよびPlin4の発現増大機構---胚環境操作により２型糖尿病-脂肪肝炎を呈するMEMマウスにおける検討---

石山詩織、中川隆生、岸上哲士、望月和樹

第76回日本栄養・食糧学会大会  2022.5 

胎生期のタンパク質・重度コリン制限による脂肪肝発症と脂肪組織のインスリン感受性遺伝子発現との関連

岩崎三奈、相澤友香、針谷夏代、平山訓子、宮本和子、望月和樹

第65回日本糖尿病学会年次学術集会  2022.5 

着床前胚の αMEM 培地暴露は，産仔マウス肝の脂肪滴形成遺伝子 Cidea 発現および同遺伝子周辺のヒス トンアセチル化を促進する

石山詩織、中川隆生、岸上哲士、望月和樹

第65回日本糖尿病学会年次学術集会  2022.5 

クメール料理における加熱調理後食品重量からの栄養価の推定

5. 根津歩、鈴木克弥、河角彩加、太田和希、千野未璃亜、平山訓子、望月和樹、宮本和子、針谷夏代

山梨県栄養士会  2022.3 

自然糖尿病モデルNSYマウスにおける中鎖脂肪とキサンチンオキシダーゼ阻害剤の糖尿病性腎症抑制効果の検証

萩原　麻衣、望月和樹

糖尿病性腎症研究会  2021.12 

石山詩織、木村真由、中川隆生、藤本由佳、岸上哲士、望月和樹

αMEM培地暴露後に産まれたマウスの糸球体硬化症および尿細管におけるTGFβ高発現は大麦投与により抑制される

糖尿病性腎症研究会  2021.12 

中鎖脂肪とトマトパウダーの共投与はラット肝臓におけるリコペン蓄積を増大させ、糖・脂質代謝関連遺伝子の発現を低下させる

木村真由　田村 彩、望月 和樹

第11回機能油脂懇話会  2021.11 

山梨県産小麦ゆめかおりの全粒粉の調理・加工特性Characteristics of Yamanashi Domestic Wholemeal Flour“Yumekaori” in Cooking and Processing.

樋口かよ、橋本卓也、長沼孝多、小嶋匡人、小松正和、木村英生、有泉直子、望月和樹

日本調理科学会  2021.9 

胎生期糖質制限が肝臓における代謝・炎症関連遺伝子のｍRNA に与える影響

山本裕昌、望月和樹　

第10回日本DOHaD学会学術集会　  2021.9 

胎生期低栄養による糖・脂質代謝異常と中鎖脂肪による改善

向井菫、山下紗輝、望月和樹

第10回日本DOHaD学会学術集会  2021.9 

胚発生時栄養不良培地暴露による糖尿病性脂肪肝・腎症の発生機構と生後の大麦摂取による改善

石山詩織、木村真由、海平のどか、松本沙知、高橋篤史、中川隆生、藤本由佳、若山照彦、岸上哲士、望月和樹

第45回日本女性栄養・代謝学会学術集会・第10回日本DOHaD学会学術集会  2021.9 

培地の保存期間がⅡ型糖尿病モデルMEMマウスの表現型に与える影響について

高橋篤史, 松本沙知, 望月和樹, 岸上哲士

第114回日本繁殖生物学会大会  2021.9 

栄養不良培地αMEM培地を用いた胚培養により作製されたマウスは、炎症性サイトカインを高発現する糖尿病モデルである

石山詩織、木村真由、海平のどか、松本沙知、高橋篤史、岸上哲士、若山照彦、中川隆生、望月和樹

第75回日本栄養・食糧学会  2021.7 

高グルコースによる糖、脂質代謝の攪乱と中鎖脂肪酸による改善 − HepG2 肝培養細胞による検討−

萩原　麻衣、望月和樹

高尿酸血症・メタボリックシンドローム リサーチフォーラム 第 17 回 研究集会  2021.7 

山梨県産小麦ゆめかおりを用いた生パスタ麺の試作　

16. 樋口かよ、橋本卓也、長沼孝多、小嶋匡人、小松正和、木村英生、有泉直子、望月和樹

日本食品保蔵科学会第70回大会  2021.6 

着床前の栄養不良培地暴露を経て産まれたMEMマウスは糖尿病性腎症を発症する(Mice derived from in vitro-αMEM cultured preimplantation embryos developed diabetic nephropathy)

石山詩織、木村真由、海平のどか、松本沙知、高橋篤史、岸上哲士、若山照彦、中川隆生、望月和樹

第64回日本腎臓学会学術総  2021.6 

糖尿病腎症モデル NSY マウスへの大麦投与は腎臓障害を進行させる

松浦弘貴、鈴木梨、望月和樹

第31回日本糖尿病性腎症研究会  2019.11 

中鎖脂肪酸の代謝改善作用とエピジェネティック制御との関連 Invited

望月 和樹　

中性脂肪学会第3回学術集会(東京)  2019.10 

中鎖脂肪による老齢期の代謝改善作用　 —Brd4ヘテロ欠損マウスを用いた検証

木村真由, 合田敏尚, 本間一江, 望月和樹

中性脂肪学会第3回学術集会　10月　東京  2019.10 

受精後のBrd4阻害剤(+)JQ1処理のタイミングの違いが着床前の発生分化に及ぼす影響について　

松本 沙知, 渡辺 連, 望月 和樹, 岸上 哲士　

第112回日本繁殖生物学会大会(札幌)  2019.9 

食後高血糖を抑制する食生活についてー糖質制限、低GI食品、食物繊維摂取などについて思うことなどー Invited

望月和樹

栄養学若手研究者の集い　第53回サマーセミナー　  2019.8 

中鎖脂肪の過剰摂取による脂肪肝形成関連遺伝子の発現攪乱とトマトパウダーによる改善 第

木村 真由、田村 彩、望月 和樹

73回日本栄養・食糧学会大会(静岡)  2019.8 

胎生期タンパク質・コリン制限が肝臓における糖・脂質代謝に及ぼす影響

相澤友香、針谷夏代、平山訓子、宮本和子、望月和樹

第8回日本DOHaD研究会 学術集会(東京)  2019.8 

胎生期低栄養に起因する生活習慣病発症リスクの中鎖脂肪による低減

向井菫、山下紗輝、望月和樹

第8回日本DOHaD研究会 学術集会(東京)  2019.8 

糖尿病腎症モデルNSYマウスへの桑の葉投与は腎臓障害を進行させる Invited

松浦　弘貴、鈴木　梨奈、望月　和樹

第62回日本腎臓学会学術総会(名古屋)  2019.6 

小腸におけるスクロースの消化吸収関連遺伝子発現のエピジェネティック制御と生活習慣病発症との関連 Invited

望月 和樹、本間 一江、竹田 裕子、針谷 夏代、合田 敏尚

第73回日本栄養・食糧学会大会(静岡)  2019.5 

大麦がアカルボースまたはメトホルミン服用2型糖尿病患者の食後血糖および血糖変動指標に与える影響の検討 Invited

遅野井 健，斎藤 三代子，玉澤 敦子，遅野井 雄介, 松岡 翼, 望月 和樹

第62回日本糖尿病学会年次学術集会  2019.5 

妊娠期のコリン・タンパク質制限が出生後の仔の肝臓における糖・脂質代謝に及ぼす影響 Invited

相澤 友香、望月 和樹

第73回日本栄養・食糧学会大会(静岡)  2019.5 

大腸炎モデルSAMP6マウスへのフラクトオリゴ糖の投与は、高脂肪食誘導性の脂肪肝の発症を抑制する

小笠原 佳弥、望月 和樹

第73回日本栄養・食糧学会大会(静岡)  2019.5 

異なる品種・産地の比較による野菜の好みに寄与する要因の抽出

木村 真由、小林 勇太、針谷 夏代、望月 和樹　

平成31年度日本食品科学工学会関東支部大会　  2019.3 

新規転写伸長エピゲノム調節機構と胎生期低栄養による生活習慣病発症との関連 Invited

望月 和樹, 針谷 夏代, 本間 一江, 合田 敏尚, 久保田 健夫

第41回　分子生物学会学術集会(岡山)  2019 

新規転写伸長エピゲノム調節機構と胎生期低栄養による生活習慣病発症との関連　

望月 和樹, 針谷 夏代, 本間 一江, 合田 敏尚, 久保田 健夫　

第41回日本分子生物学会年会　  2018.11 

2型糖尿病マウスへの大麦投与は、食後高血糖を抑制し、脂肪肝増悪遺伝子の発現を低減する

松浦　弘貴、鈴木　梨奈, 望月 和樹

第41回日本分子生物学会年会  2018.11 

中鎖脂肪による肝臓のエネルギー代謝経路遺伝子の発現促進作用　

木村 真由, 田村 彩, 望月 和樹　

第41回日本分子生物学会年会  2018.11 

中鎖脂肪とトマトパウダーの共投与がラット肝臓の脂質代謝に及ぼす影響

木村 真由, 田村 彩, 望月 和樹　

第9回　機能油脂懇話会（第20回CLA懇話会）  2018.11 

胚の体外培養液の違いが長期に及ぼす影響　

海平 のどか ，松本 沙知 ，望月 和樹，岸上 哲士

第111回 日本繁殖生物学会大会  2018.9 

大麦パンのセカンドミール効果に関する研究

松岡　翼，土田　明日香，山下　さやか，市川　陽子, 針谷　夏代, 望月　和樹

日本食品科学工学会　第65回大会  2018.8 

Treatment with Tauroursodeoxycholic Acid Improved Developmentally Programmed Hepatic Steatosis by Altering Chromatin Structures Around CIDEA And CIDEC Genes　

Urmi Jeenat Ferdous, Keiko Muramatsu-Kato, Yukiko Kohmura-Kobayashi, Kazuki Mochizuki, Takeo, Kubota, Hiroaki Itoh, Naohiro Kanayama.

2018.8 

妊娠による炎症関連遺伝子TNFのGene body領域DNAメチル化状態の変化　

金昕、今井千裕、Shilpa Pavethynath、飛知和尚美、瀧本秀美、岡光基子、Nay Chi Thun、青山友子、矢郷哲志、不殿絢子、宮坂尚幸、望月和樹、佐藤憲子　

第7回日本DOHaD学会学術集会  2018.8 

中鎖脂肪とリコペンの共投与がラットの脂質代謝に及ぼす影響　

木村 真由、田村 彩、望月 和樹　　

第72回日本栄養・食糧学会大会  2018.5 

妊娠期の葉酸過剰摂取が仔の糖・脂質代謝に及ぼす影響

金高 有里、和田 亘弘、望月 和樹　

72回日本栄養・食糧学会大会  2018.5 

レスベラトロールによる末梢血白血球の抗酸化遺伝子の発現抑制

針谷 夏代、井上 拓哉、望月 和樹

第72回日本栄養・食糧学会大会  2018.5 

大麦とろろ飯の食後糖代謝ならびにインスリンに及ぼす影響　

松岡 翼、山路 文子、黒澤 千尋、篠原 学、高山 一郎、中込 裕美、和泉 恵子、市川 陽子、針谷 夏代、望月 和樹　

第72回日本栄養・食糧学会大会  2018.5 

一過性の高グルコース環境が肝実質細胞培養株における抗酸化遺伝子の発現に与える影響

松浦 弘貴、望月 和樹

第72回日本栄養・食糧学会大会  2018.5 

嚥下困難者用食品の許可基準における TPA 試験法の測定方法およびパラメータに関す る研究　

堀井美希，荒川元喜，望月和樹，谷本守正，鈴木 裕

平成 30 年度日本食品科学工学会関東支部大会  2018.3 

過剰栄養が２型糖尿病体質を獲得させるヒストン修飾メカニズム

望月和樹　、針谷 夏代、久保田健夫　

Conbio2017  2017.12 

過剰なβ-カロテン摂取による耐糖能異常促進作用₋β-カロテン蓄積モデルスナネズミによる検討₋

安田隆史、近藤真之祐、針谷夏代、望月和樹

Conbio2017  2017.12 

ベータカロテンの過剰摂取は、脂肪肝を発症したスナネズミにおいて炎症関連タンパク質の発現を増大させる　

近藤真之祐、安田隆史、針谷夏代、望月和樹　　

Conbio2017  2017.12 

中鎖脂肪による高脂肪食誘導性肥満マウスの耐糖能異常改善効果と肝臓における遺伝子発現の変化　

川村武蔵、望月和樹

Conbio2017  2017.12 

中鎖脂肪酸の新規生理作用（エピゲノム・消化管ホルモン活性化等）による体質改善機構」

望月和樹、川村武蔵、山下紗輝

第8回機能油脂懇話会  2017.11 

脂肪肝動物モデルにおける肝炎症マーカーのアナグリプチンによる発現抑制効果第 　

近藤真之祐、安田隆史、針谷夏代、望月和樹

32 回日本糖尿病合併症学会  2017.10 

脂肪肝モデルスナネズミにおけるアナグリプチンによる脂質代謝改善作用

安田隆史、近藤真之祐、針谷夏代、望月和樹　

第 32 回日本糖尿病合併症学会  2017.10 

妊娠期の母マウスの食餌の PFC 比が出生後の仔の代謝に及ぼす影響　

工藤 美芙由、山下 紗輝、望月和樹　

第6回日本DOHaD学会学術集会　  2017.8 

胎生期からのエピゲノム異常マウスにおける中鎖脂肪食の有効性　

川村武蔵、望月和樹

第6回日本DOHaD学会学術集会  2017.8 

妊娠期のタンパク質低栄養が仔のインスリン分泌や耐糖能に及ぼす影響と中鎖脂肪による改善効果の検証

山下 紗輝、工藤 美芙由、望月和樹　　

第6回日本DOHaD学会学術集会  2017.8 

妊娠期の母マウスの食餌の異なるPFC比が出生後の仔のインスリン分泌に及ぼす影響

山下 紗輝、工藤 美芙由、望月 和樹　

第71回日本栄養・食糧学会大会  2017.5 

リコペンによる脂肪蓄積およびインスリン抵抗性増大のリスク軽減作用 ―脂肪培養細胞における検証―

木村 真由、針谷 夏代、望月 和樹

第71回日本栄養・食糧学会大会  2017.5 

高脂肪食誘導性肥満マウスにおける中鎖脂肪摂取による耐糖能改善効果

川村 武蔵、望月 和樹

第71回日本栄養・食糧学会大会  2017.5 

Effects of medium chain fatty acid on the expression of the genes related with glycolytic and fatty acid synthetic pathways in the mice refed after starvation International conference

12. Takami, S ; Matsumoto, K; Honma, K ; Mochizuki, K ; Goda, T.

Experiental biology 2017  2017.4 

糖刺激によるBRD4-ヒストンアセチル化依存的転写伸長の増進機構 Invited

望月和樹

福島県立医科大学　研究連携セミナー2017　  2017.3 

大麦配合パンの日本人に対するセカンドミール効果の検証

黒澤千尋、山路文子、針谷夏代、山下さやか、篠原学、高山一郎、中込裕美、和泉恵子、市川陽子、松岡翼、望月和樹　

日本食品科学工学会関東支部大会  2017.3  日本食品科学工学会関東支部

大麦とろろ飯の食後高血糖抑制効果の検証

山路文子、針谷夏代、黒澤千尋、篠原学、高山一郎、中込裕美、和泉恵子、市川陽子、松岡翼、望月和樹

日本食品科学工学会関東支部大会  2017.3  日本食品科学工学会関東支部

消化管を介した生活習慣病予防 Invited

望月和樹

第15回糖尿病市民セミナー・東京  2017.2  糖尿病協会　関東支部

老齢期の非肥満型耐糖能異常マウスに対する中鎖脂肪の有効性‐GLP-1分泌促進作用‐

川村 武蔵、望月和樹

第31回日本糖尿病・肥満動物学会年次学術集会  2017.2  日本糖尿病・肥満動物学会

絶食-再摂食時の肝臓における解糖系および脂肪酸合成系の遺伝子発現に及ぼす脂肪酸の影響

高見紗依子、松本氣寧子、本間一江、望月和樹、合田敏尚

第71回 日本栄養・食糧学会 中部支部大会　  2016.11  日本栄養・食糧学会 中部支部

Relations between epigenetic regulation by dietary habits and DOHaD

2016.7 

短鎖・中鎖脂肪酸によるインスリン分泌促進作用

山下紗輝、山下さやか、望月和樹　

第5回日本DOHaD研究会学術集会  2016.7 

短鎖・中鎖脂肪酸によるインスリン抵抗性体質の改善作用―マウス培養細胞を用いた検討―　

川村 武蔵、合田直樹、針谷夏代、望月和樹

第5回日本DOHaD研究会学術集会  2016.7  第5回日本DOHaD研究会

ヒストンアセチル化を介した小腸消化吸収関連遺伝子の転写制御　

本間 一江、鈴木 友莉、山田 有紀、望月和樹、合田 敏尚　

第70回日本栄養・食糧学会大会  2016.5  日本栄養・食糧学会

脂肪細胞における短鎖・中鎖脂肪酸によるインスリン抵抗性改善作用

川村 武蔵、合田 直樹、久保田 健夫、望月和樹

第70回日本栄養・食糧学会大会  2016.5  日本栄養・食糧学会

嚥下困難者用食品への利用を見据えた低メトキシルペクチンの性質と官能評価に及ぼす影響

針谷 夏代、堀井 美希、遠藤 基、佐野 笑花、荒川 元喜、西本 純、市川 陽子、谷本 守正、望月和樹

第70回日本栄養・食糧学会大会  2016.5  日本栄養・食糧学会

胚環境操作モデル脂肪肝炎MEMマウスにおけるヒストン修飾による脂肪滴蓄積遺伝子Cidea, CidecおよびPlin4発現増大機構

石山 詩織、中川 隆生、岸上 哲士、望月 和樹

Advanced Food Manufactural and Nutritional Sciences Major achievement

2023Year

Research on Bioscience A

2023Year

Seminar on Bioscience A

2023Year

Nutriepigenetics Major achievement

2023Year

Topics of Food Science

2023Year

Introduction to Bioresource Science

2023Year

生命環境学演習Ｂ

2017Year

バイオサイエンス研究Ｂ

2017Year

バイオサイエンス演習Ｂ

2017Year

バイオサイエンス研究Ａ

2017Year

バイオサイエンス演習Ａ

2017Year

生命環境学研究Ｂ

2017Year

生命環境学研究Ａ

2017Year

生命環境学演習Ａ

2017Year  Type of subject：Master's (Graduate School)

栄養学実験 Major achievement

2014Year  Type of subject：Professional education (undergraduate)

食品栄養学 Major achievement

2013Year  Type of subject：Professional education (undergraduate)

食物科学入門 Major achievement

2012Year  Type of subject：Common education (undergraduate)