Updated on 2024/05/01

写真a

 
Hirosuke Shiura
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Life and Environmental Sciences Bioagronomy (Biotechnology) Assistant Professor
Title
Assistant Professor

Research History

  • Tokyo Medical and Dental University

    2007.4 - 2009.3

  • 理化学研究所   バイオリソースセンター   特別研究員

    2009.4 - 2012.3

  • 理化学研究所   バイオリソースセンター   基礎科学特別研究員

    2012.4 - 2015.3

  • Tokyo Medical and Dental University   Assistant Professor

    2015.4 - 2018.3

Education

  • Tokyo Institute of Technology

    - 2002.3

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    Country: Japan

  • Tokyo Institute of Technology

    - 2004.3

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    Country: Japan

    Course: Master course

  • Tokyo Medical and Dental University

    2004.4 - 2007.3

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    Country: Japan

    Course: Doctor later

Degree

  • 博士(理学) ( 2007.3   東京医科歯科大学 )

Research Interests

  • エピジェネティクス

  • 哺乳類初期発生

Papers

  • Roles of retrovirus-derived PEG10 and PEG11/RTL1 in mammalian development and evolution and their involvement in human disease Reviewed

    Frontiers in Cell and Developmental Biology   2023.9( ISSN:2296-634X )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Paternally inherited H3K27me3 affects chromatin accessibility in mouse embryos produced by round spermatid injection. Reviewed

    DEVELOPMENT   2022.9( ISSN:0950-1991 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • PEG10 viral aspartic protease domain is essential for the maintenance of fetal capillary structure in the mouse placenta. Reviewed

    DEVELOPMENT   2021.10( ISSN:0950-1991 )

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice Reviewed

    Matoba S, Nakamuta S, Miura K, Hirose M, Shiura H, Kohda T, Nakamuta N, Ogura A.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   2019( ISSN:0027-8424 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Xist/Tsix expression dynamics during mouse peri-implantation development revealed by whole-mount 3D RNA-FISH. Reviewed

    Shiura H, Abe K.

    Scientific Reports   2019( ISSN:2045-2322 )

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Preferable in vitro conditions for maintaining faithful DNA methylation imprinting in mouse embryonic stem cells. Reviewed

    Lee J, Matsuzawa A, Shiura H, Sutani A, Ishino F.

    GENES TO CELLS   2018( ISSN:1356-9597 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • RNA-FISH and Immunofluorescence of the mouse pre-and post-implantation embryos.

    Shiura H, Sakata Y, Abe K, Sado T.

    Methods in Molecular Biology   2018

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype. Reviewed

    Hosoi Y, Soma M, Shiura H, Sado T, Hasuwa H, Abe K, Kohda T, Ishino F, Kobayashi S.

    Nature Communications   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Live imaging of X chromosome reactivation dynamics in early mouse development can discriminate naïve from primed pluripotent stem cells. Reviewed

    Kobayashi S, Hosoi Y, Shiura H, Yamagata K, Takahashi S, Fujihara Y, Kohda T, Okabe M, Ishino F.

    DEVELOPMENT   2016( ISSN:0950-1991 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Generation of Cloned Mice from Adult Neurons by Direct Nuclear Transfer. Reviewed

    Mizutani E, Oikawa M,Kassai H,Inoue K, Shiura H, Hirasawa R,Kamimura S, Matoba S, Ogonuki N, Nagatomo H, Abe K,Wakayama T, Aiba A, Ogura A.

    BIOLOGY OF REPRODUCTION   2015( ISSN:0006-3363 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • A Simple and Robust Method for Establishing Homogeneous Mouse Epiblast Stem Cell Lines by Wnt Signaling Inhibition Reviewed

    Sugimoto M, Kondo M, Koga Y, Shiura H, Ikeda R, Hirose M, Ogura A, Murakami A, Yoshiki A, Chuva de Sousa Lopes SM, Abe K.

    Stem Cell Reports   2015( ISSN:2213-6711 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Understanding the X chromosome inactivation cycle in mice: A comprehensive view provided by nuclear transfer. Reviewed

    Oikawa M, Inoue K, Shiura H, Matoba S, Kamimura S, Hirose M, Mekada K, Yoshiki A, Tanaka S, Abe K, Ishino F, Ogura A.

    Epigenetics   2014( ISSN:1559-2294 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Whole-mount MeFISH: A novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression. Reviewed

    Shiura H, Okamoto A, Sasaki H, Abe K.

    PLoS One   2014( ISSN:1932-6203 )

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • RNAi-mediated knockdown of Xist does not rescue the impaired development of female cloned mouse embryos. Reviewed

    Oikawa M, Matoba S, Inoue K, Kamimura S, Hirose M, Ogonuki N, Shiura H, Sugimoto M, Abe K, Ishino F, Ogura A.

    JOURNAL OF REPRODUCTION AND DEVELOPMENT   2013( ISSN:0916-8818 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Large, male germ cell-specific hypomethylated DNA domains with unique genomic and epigenomic features on the mouse X chromosome. Reviewed

    Ikeda R, Shiura H, Numata K, Sugimoto M, Kondo M, Mise N, Suzuki M, Greally JM, Abe K.

    DNA RESEARCH   2013( ISSN:1340-2838 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Generation of a novel germline stem cell line expressing a germline-specific reporter in the mouse. Reviewed

    Shiura H, Ikeda R, Lee J, Sato T, Ogonuki N, Hirose M, Ogura A, Ogawa T, Abe K.

    GENESIS   2013( ISSN:1526-954X )

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer. Reviewed

    Inoue K, Kohda T, Sugimoto M, Sado T, Ogonuki N, Matoba S, Shiura H, Ikeda R, Mochida K, Fujii T, Sawai K, Otte AP, Tian XC, Yang X, Ishino F, Abe K, Ogura A.

    SCIENCE   2010( ISSN:0036-8075 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation. Reviewed

    Shiura H, Nakamura K, Hikichi T, Hino T, Oda K, Suzuki-Migishima R, Kohda T, Kaneko-ishino T, Ishino F.

    Human Molecular Genetics   2009

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Type 2 diabetes mellitus in a non-obese mouse model induced by Meg1/Grb10 overexpression. Reviewed

    Yamamoto Y, Ishino F, Kaneko-Ishino T, Shiura H, Uchio-Yamada K, Matsuda J, Suzuki O, Sato K.

    Experimental Animals   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades. Reviewed

    Shiura H, Miyoshi N, Konishi A, Wakisaka-Saito N, Suzuki R, Muguruma K, Kohda T, Wakana S, Yokoyama M, Ishino F, Kaneko-Ishino T.

    Biochemical Biophysical Research Communications   2005

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6. Reviewed

    Ono R, Shiura H, Aburatani H, Kohda T, Kaneko-Ishino T, Ishino F.

    Genome Research   2003

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    Language:English   Publishing type:Research paper (scientific journal)  

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Teaching Experience (On-campus)

  • Seminar on Bioscience A

    2023Year

  • Research on Bioscience A

    2023Year

  • Bioengineering Experiment II

    2023Year

  • Experiments in Molecular Biology

    2023Year