Updated on 2024/05/01
University of Yamanashi University of Yamanashi Assistant Professor
2016
MEXT LEADER
2016 - 2021
JST PRESTO
2016 - 2020
AIST Molprof PI researcher
2014 - 2016
The university of Tokyo Independent researcher (HFSP Long-term Fellowship)
2011 - 2014
MIT postdoc fellow (HFSP Long-term Fellowship)
2010 - 2011
JSPS PD (The university of Tokyo)
2009 - 2010
JSPS DC2 (The university of Tokyo)
2008 - 2009
The university of Tokyo
- 2009
Country： Japan
Course： Doctor course
The university of Tokyo
- 2005
Country： Japan
Course： Master course
The University of Tokyo
- 2003
Country： Japan
The university of Tokyo ( 2009 The University of Tokyo )
There is a system for doctoral course students to support 150,000 yen a month for 3 years!
Please feel free to contact us at the e-mail.
Nanotechnology/Materials / Chemical biology
Life Science / Pharmaceutical chemistry and drug development sciences
Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering
Life Science / Cell biology
Drug discovery
regenerative medicine
Directed evolution
NGS
Genome engineering (CRISPR/Cas9)
BIoimagine
iPS cells
Optogenetics
Gene knockdown
Bioinformatics
Proteomics
Biological medicines
Cell biology
Organic chemistry
Genetic engineering
osteoporosis
virus infective disease
Alzheimer disease
Atherosclerosis
Autoimmune disease
Allergic disease
diabete
Cancer
SELEX-discovered aptamer that inhibits cellular interleukin-17/interleukin-17 receptor interaction and antagonizes interleukin-17 signaling Reviewed
Arifur Rahman Munshi, Tong Wang, Yukio Takamori, Takehiro Ando, Takumi Yokoyama, Daisuke Fuji, Zhehao Xu, Santhana Vedi, Mizuki Yamamoto, Keita Tsukamoto and Takashi Kawakami
Bioscience, Biotechnology, and Biochemistry 88 147 - 153 2023.11
Growth optimization of single-phase novel colloidal perovskite Cs3Bi2I9 nanocrystals and Cs3Bi2I9@SiO2 core-shell nanocomposites for bio-medical application Reviewed Major achievement
Santhana Vedi, Dheivasigamani Thangaraju, Govarthini seerangan Selvam, Takashi Kawakami, Narmadha Rajeswaran, Selvakumar Rajendran, Alagar Muthukaruppan, Salem Alfaify, Mohd Shkir
Biomaterials Science 10 5956 - 5967 2022.8( ISSN：2047-4830 )
In vitro display evolution of unnatural peptides spontaneously cyclized via intramolecular nucleophilic aromatic substitutions Reviewed Major achievement
Takumi Yokoyama, Takehiro Ando, Yukio Takamori, Daisuke Fuji, Masashi Sato, Santhana Vedi, Mizuki Yamamoto and Takashi Kawakami
CHEMICAL COMMUNICATIONS 58 5237 - 5240 2022.5( ISSN：1359-7345 )
Artificial aptamer that inhibits interleukin-23/interleukin-23 receptor interaction discovered via SELEX Reviewed
Yukio Takamori, Takehiro Ando, Masashi Sato, Santhana Vedi, Daisuke Fuji, Takumi Yokoyama, Keita Tsukamoto, Mizuki Yamamoto, and Takashi Kawakami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 614 17 - 21 2022.5( ISSN：0006-291X )
Discovery of IL-5-binding unnatural cyclic peptides from multiple libraries by directed evolution Reviewed
Daisuke Fuji, Takehiro Ando, Masashi Sato, Santhana Vedi, Yukio Takamori, Takumi Yokoyama, Mizuki Yamamoto, and Takashi Kawakami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 610 188 - 195 2022.4( ISSN：0006-291X )
A human epidermal growth factor receptor 3/heregulin interaction inhibitor aptamer discovered by SELEX Reviewed
Takumi Yokoyama, Takehiro Ando, Rina Iwamoto, Daisuke Fuji, Mizuki Yamamoto, and Takashi Kawakami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 553 148 - 153 2021.5( ISSN：0006-291X )
In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor Reviewed
Takehiro Ando, Mizuki Yamamoto, Yukio Takamori, Keita Tsukamoto, Daisuke Fuji, and Takashi Kawakami
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 85 ( 5 ) 1170 - 1174 2021.5( ISSN：0916-8451 )
In vitro display evolution of IL-6R-binding unnatural peptides ribosomally initiated and cyclized with m-(chloromethyl)benzoic acid Reviewed
Yukio Takamori, Takehiro Ando, Daisuke Fuji, Takumi Yokoyama, Mizuki Yamamoto, and Takashi Kawakami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 535 47 - 53 2020.12( ISSN：0006-291X )
Directed evolution of dibenzocyclooctyne-reactive peptide tags for protein labeling Reviewed
Takehiro Ando, Yukio Takamori, Takumi Yokoyama, Mizuki Yamamoto, and Takashi Kawakami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 534 27 - 33 2020.12( ISSN：0006-291X )
In vitro display evolution of the PURE system-expressed TNFα-binding unnatural cyclic peptide containing an N-methyl-D-amino acid Reviewed
Keita Tsukamoto, Takehiro Ando, Daisuke Fuji, Takumi Yokoyama, Yukio Takamori, Daisuke Horiuchi, Rina Iwamoto, Mizuki Yamamoto, and Takashi Kawakami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 534 519 - 525 2020.12( ISSN：0006-291X )
In vitro selection generates RNA aptamer that antagonizes PCSK9–LDLR interaction and recovers cellular LDL uptake Reviewed
Takehiro Ando, Mizuki Yamamoto, Takumi Yokoyama, Daisuke Horiuchi, and Takashi Kawakami
JOURNAL OF BIOSCIENCE AND BIOENGINEERING 131 ( 3 ) 326 - 332 2020.11( ISSN：1389-1723 )
Directed Evolution of a Cyclized Peptoid-Peptide Chimera against a Cell-Free Expressed Protein and Proteomic Profiling of the Interacting Proteins to Create a Protein-Protein Interaction Inhibitor Reviewed Major achievement
ACS Chemical Biology 11 ( 6 ) 1569 - 1577 2016.6( ISSN：1554-8929 )
DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells Reviewed Major achievement
CHEMISTRY & BIOLOGY 22 ( 12 ) 1671 - 1679 2015.12( ISSN：1074-5521 )
Incorporation of electrically charged N-alkyl amino acids into ribosomally synthesized peptides via post-translational conversion Reviewed Major achievement
Chemical Science 5 ( 3 ) 887 - 893 2014.3
Extensive reprogramming of the genetic code for genetically encoded synthesis of highly N-alkylated polycyclic peptidomimetics. Reviewed Major achievement
Journal of the American Chemical Society 135 ( 33 ) 12297 - 12304 2013.8
In vitro selection of multiple libraries created by genetic code reprogramming to discover macrocyclic peptides that antagonize VEGFR2 activity in living cells. Reviewed Major achievement
ACS Chemical Biology 8 ( 6 ) 1205 - 1214 2013.3
TRAP Display: A High-Speed Selection Method for the Generation of Functional Polypeptides Reviewed Major achievement
Journal of the American Chemical Society 135 5433 - 5440 2013.3
Patch cloning method for multiple site-directed and saturation mutagenesis Reviewed Major achievement
BMC Biotechnology 13 91 2013.1
Genetically Encoded Libraries of Nonstandard Peptides Reviewed Major achievement
Journal of Nucleic Acids 2012 713510 2012.8
Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library Reviewed Major achievement
Chemistry & Biology 18 ( 12 ) 1562 - 1570 2011.12
Pyrenebutyrate Leads to Cellular Binding, Not Intracellular Delivery, of Polyarginine-Quantum Dots. Reviewed Major achievement
The Journal of Physical Chemistry Letters 1 1312 - 1315 2010.1
Diverse backbone-cyclized peptides via codon reprogramming. Reviewed Major achievement
Nature Chemical Biology 5 ( 12 ) 888 - 890 2009.12
Ribosomal synthesis of polypeptoids and peptoid-peptide hybrids. Reviewed Major achievement
Journal of the American Chemical Society 130 ( 50 ) 16861 - 16863 2008.12
A caged phosphopeptide-based approach for photochemical activation of kinases in living cells. Reviewed Major achievement
ChemBioChem 9 ( 10 ) 1583 - 1586 2008.11
Messenger RNA-programmed incorporation of multiple N-methyl-amino acids into linear and cyclic peptides. Reviewed Major achievement
Chemistry & Biology 15 ( 1 ) 32 - 42 2008.11
Bone-like tissue formation by three-dimensional culture of MG63 osteosarcoma cells in gelatin hydrogels using calcium-enriched medium. Reviewed Major achievement
Tissue Engineering 12 ( 4 ) 927 - 937 2006.11
Effect of Copper Adsorption on the Mechanical Properties of Chitosan Beads Reviewed Major achievement
Journal of Applied Polymer Science 88 2988 - 2991 2003.11
ペプチド医薬品開発のための新規ペプチド環状化法の開発と非天然型環状ペプチドSELEXへの応用
高守幸男，冨士大輔，安東丈洋，横山匠，佐藤将，ベディサンタナ，山本美月，川上隆史
バイオインダストリー 9 - 17 2022.7
２種類の人工塩基を有するDNAアプタマー
山本美月、川上隆史
実験医学 62 - 63 2018.1
細胞膜透過性ペプチド創製を指向したPUREシステムとmRNAディスプレイ法による大環状Nアルキルペプチドの超高速スクリーニン
山本美月、清水優、川上隆史
332 - 342 2017.12
ペプチド医薬品開発のための新規ペプチド環状化法の開発と非天然型環状ペプチドSELEX への応用
高守幸男、冨士大輔、安東丈洋、横山匠、佐藤将、ベディサンタナ、山本美月、川上隆史（ Role： Joint Work）
シーエムシー出版 2022.7
２種類の人工塩基を有するDNAアプタマー
山本美月、川上隆史（ Role： Joint Work）
羊土社 2018.1
細胞膜透過性ペプチド創製を指向したPUREシステムとmRNAディスプレイ法による大環状Nアルキルペプチドの超高速スクリーニング
山本美月、清水優、川上隆史（ Role： Joint Work）
技術情報協会 2017.12
がん免疫療法治療薬開発のための新規ペプチド阻害剤のPUREシステムとmRNAディスプレイ法を用いた探索と機能解析
日本農芸化学会2022年度大会 2022.3
血管新生阻害のための新規VEGFR2/VEGF間相互作用阻害剤の探索と機能解析、第73回日本細胞生物学会大会
第73回日本細胞生物学会大会 2021.6
アレルギー性疾患治療のための新規ペプチド阻害剤の探索と機能解析
第73回日本細胞生物学会大会 2021.6
自己免疫疾患治療薬開発のための新規TNFα/TNFR間相互作用阻害剤の開発
日本薬学会第141年会 2021.3
高LDLコレステロール血症治療のための新規PCSK9/LDLR間相互作用阻害剤の開発と機能解析
第94回日本薬理学会年会 2021.3
血管新生阻害のための新規VEGFR2/VEGF間相互作用阻害剤の開発と機能解析
第94回日本薬理学会年会 2021.3
自己免疫疾患治療のための新規IL-6R/IL6間相互作用阻害剤の開発と機能解析
第94回日本薬理学会年会 2021.3
自己免疫疾患治療のための新規TNFα/TNFR間相互作用阻害剤の開発と機能解析
第94回日本薬理学会年会 2021.3
がん免疫療法のための新規PD-L1/PD-1間相互作用阻害剤の開発と機能解析
第94回日本薬理学会年会 2021.3
がん分子標的治療のための新規HER3/HRG間相互作用阻害剤の開発と機能解析
第94回日本薬理学会年会 2021.3
PUREシステムとcDNAディスプレイを用いたSELEX法による小分子反応性ペプチドタグの創製
日本化学会 第101春季年会 2021.3
動脈硬化症治療薬開発のための新規ペプチド阻害剤のPUREシステムとmRNAディスプレイ法を用いた探索
日本農芸化学会2021年度大会 2021.3
COVID-19重症肺炎疾患治療薬開発のための新規IL-6R/IL6間相互作用阻害剤の開発
日本薬学会第141年会 2021.3
PUREシステムとcDNAディスプレイを用いたSELEX法による新規小分子結合ペプチドタグの同定
第43回日本分子生物学会年会 2020.12
Imaging and manipulating proteins in living mammalian cells by small-molecule-binding peptide tags International conference
JAACT2020 2020.11
PURE system-based mRNA display evolution of unnatural cyclic peptides via genetic code expansion for hypercholesterolemia treatment
第57回ペプチド討論会 2020.11
PURE system-based mRNA display evolution of unnatural cyclic peptides via genetic code expansion for cancer treatment
第57回ペプチド討論会 2020.11
PURE system-based mRNA display evolution of unnatural cyclic peptides via genetic code expansion for autoimmune disease treatment
第57回ペプチド討論会 2020.11
PURE system-based mRNA display evolution of unnatural cyclic N-alkyl peptides via genetic code expansion for autoimmune disease treatment
第57回ペプチド討論会 2020.11
PURE system-based mRNA display evolution of unnatural cyclic N-alkyl peptides via genetic code expansion for cancer treatment
第57回ペプチド討論会 2020.11
PURE system-based cDNA Display Evolution of Small Molecule-Binding Peptide Tags for protein modification
第57回ペプチド討論会 2020.11
PURE system-based cDNA Display Evolution of Small Molecule-Binding Peptide Tags for imaging and controlling cellular proteins
第57回ペプチド討論会 2020.11
Novel Cyclic N-alkyl Peptides as BFGF Mimetics to Maintain the Pluripotency of Human Induced Pluripotent Stem Cells International conference
JAACT2020 2020.11
Small-molecule-binding peptide tags for imaging and manipulating proteins in living mammalian cells International conference
JAACT2020 2020.11
新型コロナウィルスによる重症肺炎の治療薬開発のための新規ペプチド阻害剤のPUREシステムとmRNAディスプレイ法による探索
第93回日本生化学会大会 2020.9
脂質異常症治療薬の開発を目指した新規PCSK9/LDLR間相互作用阻害アプタマーのSELEX法による探索
第93回日本生化学会大会 2020.9
脂質異常症の治療・診断のための新規ペプチド化合物のPUREシステムとmRNAディスプレイ法による開発
第93回日本生化学会大会 2020.9
がん分子標的治療を目指した新規ペプチド阻害剤のPUREシステムとmRNAディスプレイ法による開発
第93回日本生化学会大会 2020.9
PUREシステムとcDNAディスプレイ法を用いた新規小分子結合ペプチドタグの開発と細胞内タンパク質蛍光イメージングへの応用
第72回日本細胞生物学会大会 2020.6
分子進化工学的スクリーニング法を用いた機能性タンパク質のペプチドへの小型化 Invited
新学術領域研究「化学コミュニケーションのフロンティア」第4回若手シンポジウム 2019.12
Development of novel peptides useful for promoting growth and undifferentiation of induced pluripotent stem cells
第56回ペプチド討論会 2019.10
Development of novel protein G-binding peptide tags for recombinant protein purification
第56回ペプチド討論会 2019.10
Directed evolution of a novel peptoid-peptide chimera for cancer treatment
第56回ペプチド討論会 2019.10
Directed evolution of a novel PCSK9-binding peptide for hypercholesterolemia treatment
第56回ペプチド討論会 2019.10
Development of a novel small molecule-binding peptide tag and its application to bioimaging
第56回ペプチド討論会 2019.10
ヒトiPS細胞の未分化増殖を可能にする新規ペプチド化合物の分子進化工学的スクリーニング法による探索及び人工FGFRアゴニストとしての機能解析
第71回日本生物工学会大会 2019.9
ガン分子標的治療薬の開発を目指した新規HER3結合分子の探索
日本ケミカルバイオロジー学会第14回年会 2019.6
自己免疫性炎症性疾患の治療を志向した新規IL-6R結合分子の探索
日本ケミカルバイオロジー学会第14回年会 2019.6
低免疫応答性抗体医薬品の単離を可能にする新規Fc結合ペプチドの開発
日本ケミカルバイオロジー学会第14回年会 2019.6
高LDLコレステロール血症治療薬の開発を目指した新規PCSK9結合分子の探索
日本ケミカルバイオロジー学会第14回年会 2019.6
Ultra-high-throughput Screening of Cyclic N-alkyl Peptides Useful for Maintaining Pluripotency and Growth of Induced Pluripotent Stem Cells International conference
10th International Peptide Symposium 2018.12
Development of Novel PCSK9-Binding Cyclic Peptides for Hyperlipidemia Treatment International conference
10th International Peptide Symposium 2018.12
ケミカルバイオロジーを基盤とする機能性ペプチドの創製 Invited
Kofu Stem Cell Conference 2018.8
In vitro selection of anti-IL6R RNA to identify an IL6/IL6R interaction inhibitor
2018.6
Development of novel small molecular binding peptide tag and its application to bioimaging
2018.6
Development of Fc-binding peptides for increasing drug’s plasma half-life
2018.6
Peptide Selection against Reactive Small Molecular Probes for Protein Imaging and Opto-genetics by Using the DIVERSE Screening System
第54回ペプチド討論会 2017.11
ChemistryからBiologyへの展開-DIVERSEスクリーニングシステムの開発とバイオイメージングへの応用-
2017.3
DIVERSEシステムを用いた蛋白質ラベリング用ペプチドタグ創製とバイオイメージングへの応用
2017.1
Site-specific Labeling of Peptide-tagged Proteins with Nano-sized Fluorescent Probes in Living Cells for Single-molecule Imaging
2016.10
De Novo Creation of Non-enzymatically Covalent-labeling Peptide Tags for Protein Imaging by Using the DIVERSE System
2016.10
試験管内分子進化法を用いたPPI阻害環状Nアルキルペプチド化合物の創製
2016.2
進化分子工学と有機合成化学を基盤とするペプチドツール創製システムの構築
2015.10
芳香族求核置換反応で環化する環状ペプチド及びそれらのペプチドライブラリー、製造方法並びにスクリーニング方法
川上隆史
井上研究奨励賞
2012.12 井上科学振興財団
Applied Chemical Biology
2023Year Type of subject：Master's (Graduate School)
Advanced Lecture on Molecular Evolution
2023Year Type of subject：Dr. (Graduate School)
Biochemistry I
2023Year
Scientific Presentation A
2023Year
Research on Bioscience A
2023Year Type of subject：Master's (Graduate School)
Experiments in Biochemistry
2022Year
