山梨大学大学院総合研究部・薬理学講座　特任助教

2012.3

Assistant Researcher (track III), Department of Physiology (PI, Dr Baljist S Khakh), UCLA

2011.7

Assistant Researcher (track I), Department of Physiology (PI, Dr Baljist S Khakh), UCLA

2010.4

Postdoctoral Scholar, Department of Physiology (PI, Dr Baljist S Khakh), UCLA・上原生命科学財団海外ポストドクトラルフェロー

2007.4

日本学術振興会特別研究員(PD)・東京慈恵会医科大学訪問研究員 （神経生理学研究室・加藤総夫教授）

2005.4

Transplantation of Human Induced Pluripotent Stem Cell-Derived Microglia in Immunocompetent Mice Brain via Non-Invasive Transnasal Route. Reviewed

4. Parajuli B, Shinozaki Y, Shigetomi E, Koizumi S.

Jove-Journal of Visualized Experiments   2022.5( ISSN：1940-087X )

Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice. Reviewed

5. Danjo Y, Shigetomi E, Hirayama YJ, Kobayashi K, Ishikawa T, Fukazawa Y, Shibata S, Takanashi K, Parajuli B, Shinozaki Y, Kim SK, Nabekura J, Koizumi S.

JOURNAL OF EXPERIMENTAL MEDICINE   219 ( 4 )   2022.4( ISSN：0022-1007 )

Effects of fatty acid metabolites on nocturia. Reviewed

Ihara T, Shimura H, Tsuchiya S, Kanda M, Kira S, Sawada N, Takeda M, Mitsui T, Shigetomi E, Shinozaki Y, Koizumi S.

Scientific Reports   2022.2( ISSN：2045-2322 )

Abnormal Ca2+ Signals in Reactive Astrocytes as a Common Cause of Brain Diseases. Reviewed

Koizumi S, Shigetomi E, Sano F, Saito K, Kim SK, Nabekura J.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   2021.12

アストロサイトによる情動制御

繁冨英治、小泉修一

生体の科学   72   438 - 441   2021.10

Adenosine A2B Receptor down-regulates Metabotropic Glutamate Receptor 5 in astrocytes during postnatal development. Reviewed

2. Tanaka M, Shigetomi E, Parajuli B, Nagatomo H, Shinozaki Y, Hirayama Y, Saito K, Kubota Y, Danjo Y, Lee JH, Kim SK, Nabekura J, Koizumi S.

GLIA   2021.8( ISSN：0894-1491 )

Different effect of GsMTx4 on nocturia associated with the circadian clock and Piezo1 expression in mice. Reviewed

6. Ihara T, Mitsui T, Shimura H, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Koizumi S. and Takeda, M.

LIFE SCIENCES   2021.8( ISSN：0024-3205 )

Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice. Reviewed

4. Parajuli B, Saito H, Shinozaki Y, Shigetomi E, Miwa H, Yoneda S, Tanimura M, Omachi S, Asaki T, Takahashi K, Fujita M, Nakashima K, Koizumi S.

GLIA   2021.7( ISSN：0894-1491 )

Development of a label-free ATP image sensor for analyzing spatiotemporal patterns of ATP release from biological tissues. Reviewed

5. Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S and Sawada K.

SENSORS AND ACTUATORS B-CHEMICAL   2021.5

Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus. Reviewed

3. Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K Horiuchi H, Cheung DL, Nabekura J, Sugita K, Aihara M, Koizumi S.

JCI Insight   2021.4

グリア性てんかん原生のメカニズム.

佐野史和、繁冨英治、小泉修一.

脳神経内科   93 ( 4 )   441 - 446   2020.10

Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia. Reviewed

Ihara T, Nakamura Y, Mitsui T, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Koizumi S, Takeda M.

Scientific Reports   2019.11( ISSN：2045-2322 )

グリア―ニューロン間情報発信・受信イメージング技術.

繁冨英治、小泉修一.

実験医学   37 ( 17 )   182 - 188   2019.10

Aberrant Calcium Signals in Reactive Astrocytes: A Key Process in Neurological Disorders. Reviewed Major achievement

Shigetomi E, Saito K, Sano F, Koizumi S.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   2019.2( ISSN：1422-0067 )

てんかん病態における反応性アストロサイトの役割.

繁冨英治、小泉修一、佐野史和.

BIO Clinica   33 ( 11 )   71 - 76   2018.10

The time-dependent variation of ATP release in mouse primary-cultured urothelial cells is regulated by the clock gene. Reviewed

Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M, Koizumi S.

NEUROUROLOGY AND URODYNAMICS   2018.8( ISSN：0733-2467 )

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes. Reviewed

Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki Y, Shigetomi E, Takeda A, Le HPN, Hayashi H, Hiasa M, Moriyama Y, Ikenaka K, Tanaka KF, Koizumi S.

EBioMedicine   2018.6( ISSN：2352-3964 )

アストロサイトによる睡眠覚醒サイクルの調節. Invited Reviewed

繁冨英治

ファルマシア   54 ( 6 )   578 - 578   2018.6

The oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium.

Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Hirayama Y, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M, Koizumi S.

Scientific Reports   2018.4( ISSN：2045-2322 )

News & Hot Paper Digest「外側手綱核アストロサイトのカリウムチャネルとうつ病の関係」 Invited

繁冨英治

実験医学   36 ( 6 )   981 - 982   2018.3

Role of Purinergic Receptor P2Y1 in Spatiotemporal Ca2+ Dynamics in Astrocytes. Reviewed Major achievement

Shigetomi E, Hirayama YJ, Ikenaka K, Tanaka KF, Koizumi S.

JOURNAL OF NEUROSCIENCE   2018.2( ISSN：0270-6474 )

Aberrant astrocyte Ca2+ signals "AxCa signals" exacerbate pathological alterations in an Alexander disease model. Reviewed Major achievement

Saito K, Shigetomi E, Yasuda R, Sato R, Nakano M, Tashiro K, Tanaka KF, Ikenaka K, Mikoshiba K, Mizuta I, Yoshida T, Nakagawa M, Mizuno T, Koizumi S.

GLIA   2018.1( ISSN：0894-1491 )

The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells. Reviewed

Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M, Koizumi S.

NEUROUROLOGY AND URODYNAMICS   2017.9( ISSN：0733-2467 )

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Reviewed

Chai H, Diaz-Castro B, Shigetomi E, Monte E, Octeau JC, Yu X, Cohn W, Rajendran PS, Vondriska TM, Whitelegge JP, Coppola G, Khakh BS.

NEURON   2017.7( ISSN：0896-6273 )

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Reviewed

Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S.

Nature Communications   8 ( 1 )   2017.6( ISSN：2041-1723 )

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y(1) Receptor Downregulation Reviewed

Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S.

Cell Reports   19 ( 6 )   1151 - 1164   2017.5( ISSN：2211-1247 )

P2Y(6)-deficiency increases micturition frequency and attenuates sustained contractility of the urinary bladder in mice. Reviewed

Kira S, Yoshiyama M, Tsuchiya S, Shigetomi E, Miyamoto T, Nakagomi H, Shibata K, Mochizuki T, Takeda M, Koizumi S.

Scientific Reports   7 ( 1 )   2017.4( ISSN：2045-2322 )

Clock Genes Regulate the Circadian Expression on Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa Reviewed Major achievement

PLoS One   12 ( 1 )   1 - 17   2017.1( ISSN：1932-6203 )

アストロサイトのCa2+シグナルの多様性とその可視化技術 Reviewed Major achievement

日本薬理学雑誌   148 ( 2 )   75 - 80   2016.8

Urothelial ATP exocytosis: regulation of bladder compliance in the urine strage phase Reviewed

Scientific Reports   2016.7( ISSN：2045-2322 )

Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain. Reviewed

Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee G, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S, Nabekura J.

JOURNAL OF CLINICAL INVESTIGATION   126 ( 5 )   1983 - 1997   2016.5( ISSN：0021-9738 )

Probing the Complexities of Astrocyte Calcium Signaling. Reviewed Major achievement

TRENDS IN CELL BIOLOGY   26 ( 4 )   300 - 312   2016.4( ISSN：0962-8924 )

The Clock Mutant Mouse Is a Novel Experimental Model for Nocturia and Nocturnal Polyuria Reviewed

NEUROUROLOGY AND URODYNAMICS   2016.4( ISSN：0733-2467 )

Muller cell-mediated neurite outgrowth of the retinal ganglion cells via P2Y6 receptor signals. Reviewed

Journal of Neurochemistry   136 ( 4 )   741 - 751   2015.11

アストロサイトアセンブリ新規可視化技術と新機能 Reviewed

日本生物学的精神医学会誌   26 ( 3 )   129 - 133   2015.9

TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release. Reviewed Major achievement

The Journal of Neuroscience   33 ( 24 )   10143 - 10153   2013.6

新規Ca2+可視化技術で見えたアストロサイトによるシナプス制御機構 Major achievement

実験医学   31 ( 11 )   1705 - 1711   2013.6

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. Reviewed Major achievement

The Journal of General Physiology   141 ( 5 )   633 - 647   2013.5

アストロサイトのカルシウムを介した脳機能制御 Major achievement

繁冨　英治

医学のあゆみ   244 ( 6 )   559 - 560   2013.2

Genetically Encoded Calcium Indicators and Astrocyte Calcium Microdomains. Reviewed Major achievement

The Neuroscientist   2013.1

Optimisation of a GCaMP Calcium Indicator for Neural Activity Imaging. Reviewed Major achievement

The Journal of Neuroscience   32 ( 40 )   13819 - 13840   2012.10

TRPA1 channels regulate astrocyte resting calcium levels and inhibitory synapse efficacy through GAT-3. Reviewed Major achievement

Nature Neuroscience   15 ( 1 )   70 - 80   2011.12

Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated. Reviewed

The Journal of Neuroscience   31   16716 - 16730   2011.11

アストロサイトによるシナプス伝達調節 Reviewed Major achievement

加藤総夫,繁冨英治

日本薬理学雑誌   138   161 - 165   2011.10

Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps. Reviewed Major achievement

The Journal of Neuroscience   31   9353 - 9358   2011.6

Monitoring astrocyte microdomains with improved membrane　targeted GCaMP reporters. Reviewed Major achievement

Neuron Glia Biology   1 - 9   2010.8

A genetically targeted optical sensor to monitor calcium signals in astrocyte processes. Reviewed Major achievement

Nature Neuroscience   759 - 766   2010.6

Measuring near plasma membrane and global intracellular calcium dynamics in astrocytes. Reviewed Major achievement

Journal of Visualized Experiments   2009.4

Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons. Reviewed Major achievement

The Journal of Neuroscience   ( 28 )   6659 - 6663   2008.6

Tracking transmitter-gated P2X cation channel activation in vitro and in vivo. Reviewed Major achievement

Nature Methods   5 ( 1 )   87 - 93   2008.1

細胞外プリン・シグナル系と脳内シナプス伝達 Reviewed

加藤 総夫,井村 泰子,繁冨 英治

日本神経精神薬理学雑誌   27   117 - 126   2007.6

Facilitation of spontaneous glycine release by anoxia potentiates NMDA receptor current in the hypoglossal motor neurons of the rat. Reviewed

European Journal of Neuroscience   25   1748 - 1756   2007.3

Blocker-resistant presynaptic voltage-dependent Ca2+ channels underlying glutamate release in mice nucleus tractus solitarii. Reviewed

Brain Research   1104   103 - 113   2006.8

Action potential-independent release of glutamate by Ca2+ entry through presynaptic P2X receptors elicits postsynaptic firing in the brainstem autonomic network. Reviewed Major achievement

The Journal of Neuroscience   24   3125 - 3135   2004.3

Synaptic purinoceptors - the stage for ATP to play its “dual-role”. Reviewed

Journal of Pharmacological Sciences   94   107 - 111   2004.2

A dual-role played by extracellular ATP in frequency-filtering of the nucleus tractus solitarii network.

Kato F, Shigetomi E, Yamazaki K, Tsuji N, Takano K

Advance in Experimental Medicine and Biology   551   151 - 156   2004

Differential increases in P2X receptor levels in rat vagal efferent neurones following a vagal nerve section. Reviewed

Brain Research   977   112 - 118   2003.7

脳幹スライスにおけるパッチクランプ法を用いた脳幹ネットワークのシナプス伝達解析法 Reviewed

加藤 総夫,繁冨 英治,川村 将仁,池田 亮

日本薬理学雑誌   121   255 - 263   2003.4

Distinct modulation of evoked and spontaneous EPSCs by purinoceptors in the nucleus tractus solitarii of the rat. Reviewed Major achievement

The Journal of Physiology   530   469 - 486   2000.2

Ca2+イメージセンサーを用いた海馬の細胞外Ca2+の可視化

2022.12 

アレキサンダー病において変異アストロサイトが引き起こす髄鞘脱落のメカニズム

2022.12 

「一次性アストロサイト病」アレキサンダー病におけるミクログリアの病態関連機序の解明

2022.12 

ミクログリアによるATP/P2Y1シグナルを介したニューロン–アストロサイト間情報伝達の制御

鈴木秀明、繁冨英治、平山幸歩、高橋由香里、池中一裕、田中謙二、加藤総夫、尾藤晴彦、小泉修一

第96回日本薬理学会年会  2022.11 

グリアによる脳–身体連関制御の包括的操作・解析–アレキサンダー病において変異アストロサイトが髄鞘脱落を引き起こすメカニズム

2022.10 

“一次性アストロサイト病”アレキサンダー病モデルのミクログリア機能解析

2022.10 

ミクログリアデコーディングによる全身監視・制御システムの解明

坂井謙斗、繁冨英治、中村勇規、大平なぎさ、宮川美保、中尾篤人、小泉修一

第4回グリアデコード領域会議  2022.10 

グリア細胞の異常が緑内障の原因となる可能性

2022.9 

The spatiotemporal features of astrocytic Ca2+ signals during latent phase of epilepsy.

2022.9 

Neuronal hyper-excitability driven by astrocytic P2Y1 receptor signaling. International conference

Shigetomi E, Suzuki H, Hirayama YJ, Sano F, Koizumi S.

ISN-APSN 2022 Meeting  2022.9 

アストロサイトのABCA1欠損による細胞非自律的視神経症発症機構の解明

2022.7 

ミクログリア置換は一次性アストロサイト疾患であるアレキサンダー病に対する新たな治療戦略となり得る。

2022.7 

臨界期アストロサイトは、ミクログリアによる貪食を制御することで大脳皮質神経回路を形成する

2022.7 

アストロサイトP2Y1受容体を介した双方向性情報伝達の増強による神経過興奮

鈴木秀明、繁冨英治、平山幸歩、高橋由香里、池中一裕、田中謙二、加藤総夫、尾藤晴彦、小泉修一

第１４６回日本薬理学会関東部会  2022.6 

グリア細胞の異常が緑内障の原因となる可能性

2022.6 

アストロサイト活性化による情動制御

繁冨英治

第40回山梨神経科学研究会  2022.6 

The spatiotemporal features of astrocytic Ca2+ signals during latent phase of epilepsy.

2022.6 

Spatiotemporal dynamics of extracellular ADO revealed by genetically encoded ADO sensor in situ brain slice experiments. International conference

Sakai K, Shigetomi E, Suzuki H, Koizumi S.

The third international symposium on brain science:University of Yamanashi  2022.3 

Spatiotemporal dynamics in glia-neuron communication through ATP signaling

Eiji Shigetomi, Schuichi Koizumi

2022.3 

Chemogenetic activation of astrocytes in the ventral hippocampus

Eiji Shigetomi, Schuichi Koizumi

2022.3 

臨界期アストロサイトは、ミクログリアによる貪食を制御することで大脳皮質神経回路を形成する

檀上洋右、篠﨑陽一、出羽健一、小林憲司、瀬川高弘、繁冨英治、小泉修一

第95回日本薬理学会年会  2022.3 

ミクログリアによるニューロンーアストロサイト間情報伝達の制御機構

鈴木秀明、繁冨英治、平山幸歩、高橋由香里、池中一裕、田中謙二、加藤総夫、尾藤晴彦、小泉修一

第95回日本薬理学会年会  2022.3 

一次性アストロサイト疾患であるアレキサンダー病への治療標的としてミクログリア置換が有用である。

小林憲司、繁冨英治、パラジュリ　ビージェイ、久保田友人、斎藤光象、田中謙二、池中一裕、小泉修一

第95回日本薬理学会年会  2022.3 

Spatiotemporal dynamics of extracellular ADO revealed by genetically encoded ADO sensor in situ brain slice experiments.

Kent Sakai, Eiji Shigetomi, Hideaki Suzuki, Schuichi Koizumi

2022.3 

アレキサンダー病モデルのミクログリアCa2+シグナル研究

齋藤光象、繁冨英治、小泉修一

第95回日本薬理学会年会  2022.3 

網膜アストロサイトは緑内障の発症過程において炎症を惹起する

篠﨑陽一、Leung Alex、行方和彦、柏木賢治、大野伸彦、繁冨英治、瀬川高弘、原田高幸、大沼信一、小泉修一

第95回日本薬理学会年会  2022.3 

グリアーニューロン間ATPシグナルによる神経興奮性制御

繁冨英治、鈴木秀明、平山幸歩、佐野史和、小泉修一

第3回グリアデコード領域会議  2021.12 

Regulation of synapse formation through astrocytic A2B receptor in postnatal development

Eiji Shigetomi, Masayoshi Tanaka, Schuichi Koizumi

2021.12 

網膜アストロサイトの異常による正常眼圧緑内障様症状の誘導

篠崎陽一、行方和彦、大野伸彦、繁冨英治、瀬川高弘、柏木賢治、原田高幸、小泉修一

第41回日本眼薬理学会  2021.11 

ミュラー細胞のP2Y1受容体の欠如が網膜神経節細胞の変性を引き起こす

濱田健太郎、篠崎陽一、檀上洋右、久保田友人、夏堀晃世、齊藤光象、パラジュリ　ビージェイ、繁冨英治、柏木賢治、田中謙二、小泉修一

第64回日本神経化学会大会  2021.10 

Astrocytic ABCA1 deficiency causes neuroinflammation during pathogenesis of glaucoma.

2021.9 

ニューロン-グリア間情報伝達の可視化

繁冨英治、小泉修一

第64回日本神経化学会大会  2021.9 

Ultra-wide Ca2+ spread in astrocytes during status epilepticus.

2021.9 

Glial cell-dependent epileptogenesis.

2021.9 

臨界期アストロサイトのｍGluR5シグナルはミクログリアによる貪食を制御することで大脳皮質神経回路を形成する International conference

2021.7 

Communication among neuron, astrocyte and microglia via P2Y1 receptor. International conference

2021.7 

Multimodal imaging of glia-neuron interaction International conference

Eiji Shigetomi, Schuichi Koizumi

2021.7 

Regulation of Synapse Formation through A2B receptor in Astrocytes in Postnatal Development. International conference

SLDDDRS WEBINAR SERIES 2021-2023  2021.6 

ミクログリア置換によるアレキサンダー病への介入

小林憲司、繁冨英治、パラジュリ　ビージェイ、檀上洋右、久保田友人、斎藤光象、田中謙二、池中一裕、小泉修一

第144回日本薬理学会関東部会  2021.6 

Contribution of IP3R2-mediated astrocytic activation in epileptogenesis after status epilepticus.

2021.5 

Astrocyte-neuron interaction through Gq-protein coupled receptor signaling Invited

2021.3 

視神経乳頭部アストロサイトは正常眼圧緑内障の早期に活性化する

篠崎陽一、行方和彦、柏木賢治、大野伸彦、繁冨英治、原田高幸、小泉修一

第94回日本薬理学会年会  2021.3 

腹側海馬アストロサイトの化学遺伝学的操作

繁冨英治、小泉修一

第94回日本薬理学会年会  2021.3 

アストロサイトP2Y1受容体を介したニューロン興奮性制御

鈴木秀明、繁冨英治、平山幸歩、佐野史和、田中謙二、尾藤晴彦、小泉修一

第94回日本薬理学会年会  2021.3 

Ca2+イメージセンサーを用いた海馬の細胞外Ca2+の可視化

パラジュリビージェイ, 土井英生, 繁冨英治, 篠崎陽一, 野田俊彦, 高橋一浩, 澤田和明, 小泉修一.

第94回日本薬理学会年会  2021.3 

ミクログリアの再増殖は一次性アストロサイト疾患であるアレキサンダー病の病態を改善する

小林憲司、繁冨英治、パラジュリビージェイ、久保田友人、齋藤光象、田中謙二、池中一裕、小泉修一

第94回日本薬理学会年会  2021.3 

Astrocytic mGluR5 controls microglial phagocytosis in the critical period, which fates a lifelong cortical circuits

2021.3 

グリア研究による脳疾患の解明と創薬を目指して～アストロサイトに魅せられて～

繁冨英治、小泉修一

第13回日本薬学会関東支部若手シンポジウム  2020.9 

ミクログリアの自己再生によるアレキサンダー病の抑制

小林憲司、繁冨英治、パラジュリビージェイ、久保田友人、齋藤光象、田中謙二、池中一裕、小泉修一

第63回日本神経化学会大会  2020.9 

ABCA1欠損は緑内障発症過程早期でのグリオーシスを誘導する

篠崎陽一、行方和彦、柏木賢治、大野伸彦、繁冨英治、原田高幸、小泉修一

第63回日本神経化学会大会  2020.9 

P2Y1受容体を介したニューロン-アストロサイト-ミクログリア間情報処理機構

鈴木秀明、繁冨英治、平山幸歩、佐野史和、田中謙二、尾藤晴彦、小泉修一

第63回日本神経化学会大会  2020.9 

腹側海馬アストロサイトにおけるGqPCRシグナルがマウス行動に与える影響

繁冨英治、小泉修一

第63回日本神経化学会大会  2020.9 

The mGluR5 signaling in reactive astrocytes promotes mossy fiber sprouting for epileptogenesis.

2020.8 

Neuronal hyperexcitability mediated by GqPCR-mediated signaling in astrocytes

2020.3 

Research on the molecular pathogenesis of "primary astrocyte disorder" Alexander disease.

2020.3 

Imaging of extracellular Ca2+ in the hippocampus by a novel CMOS ion image sensor

2020.3 

Astrocytes in the critical period regulate synapse-scaling microglia

2020.3 

Multi-modal imaging of astrocyte-neuron communication. Invited International conference

Shigetomi, E., Koizumi, S.

2nd Mini-Symposium on The Blood-Brain Barrier from Basic to Clinical Research.  2020.3 

活性化ミクログリアによるてんかん原性型アストロサイトの誘導

佐野史和、繁冨英治、小泉修一

第53回てんかん学会学術集会  2019.11 

Dynamic feature of bidirectional communication between neurons and glia.

Shigetomi, E.

YougGlia Meeting at Université Laval  2019.8 

Re-emergence of astrocytic mGluR5 assembles cortical networks in induction of neuropathic pain.

Danjo, Y., Hirayama, YJ., Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim SK., Nabekura, J., Koizumi, S.

2019.7 

Involvement of microglia in Alexander Disease, the primary astrocytic disease.

2019.7 

Dynamic feature of bidirectional communication between neurons and astrocytes.

Shigetimi, E., Hirayama, YJ., Ikenaka, K., Tanaka, KF., Bito, H., Koizumi, S.

Neuro2019  2019.7 

アストロサイトの異常カルシウムシグナルとその病態生理学的意義

繁冨英治、齋藤光象、小泉修一

第140回日本薬理学会関東部会  2019.7 

Monitoring of bidirectional communications between neurons and glia.

Shigetomi, E., Hirayama, JY., Ikenaka, K., Tanaka, KF., Bito, H., Koizumi, S.

新学術領域研究「脳情報動態を規定する多領野連関と並列処理」第3回領域会議  2019.7 

新規カルシウムイメージング技術により明らかとなったアストロサイト機能 Invited

繁冨英治

Center for Development of Advanced Medicine for Dementiaセミナー  2019.6 

Identification of epileptogenic astrocyte mediated by astrocytic Ca2+ signals via IP3 receptor type2.

2019.5 

Astrocytic Ca2+ signals via IP3 receptor type2 mediate reactive astrocytes after status epilepticus. International conference

Sano F, Shigetomi E, Koizumi S, Kanemaru H, Mikoshiba K, Aihara M.

FAOPS2019  2019.3 

Visualization of spatiotemporal interaction of neurons and astrocytes. International conference

Shigetomi, E., Hirayama, JY., Ikenaka, K., Tanaka, FK., Bito, H., Koizumi, S.

FAOPS2019  2019.3 

Role of calcium signals in reactive astrocytes. International conference

Shigetomi, E.

Université Laval  2019.3 

Monitoring bidirectional information processing between neurons and astrocyte.

Shigetomi, E., Koizumi, S.

2019.3 

Role of microglia in Alexander disease: the influence of microglia depletion.

Kobayashi, K., Shigetomi, E., Sito, K., Ikenaka, K., Tanaka, FK., Kozumi, S.

第92回日本薬理学会年会  2019.3 

Reappearance of astrocytic mGluR5 assembles cortical networks in induction of neuropathic pain.

Danjo, Y., Hirayama, YJ, Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK, Nabekura, J., Koizumi, S.

2019.3 

Imaging of non-labeled gliotransmitters by a CCD-type bio-sensor. International conference

Koizumi, S., Doi, H., Lee, Y., Shigetomi, E., Parajuli, B., Shinozaki, Y., Sawada, K.

12th International workshop on approaches to single cell analysis.  2019.3 

Dual-Color　Ca2+　imagingを用いたニューロン-アストロサイト連関の可視化

繁冨英治、平山幸歩、小泉修一

2019CREST合同ミーティング  2019.1 

Spatiotemporal analysis of Neuron-Astrocyte interaction by dual-color calcium imaging. International conference

Shigetomi, E., Hirayama, Y., Ikenaka, K., Tanaka, FK., Bito, H., Koizumi, S.

2018 Cold Spring Harbor Asia Conference.  2018.12 

Astrogliosis by status epilepticus is dependent on IP3 receptor type2.

佐野史和、繁冨英治、小泉修一、金村英秋、御子柴克彦、相原正男

第52回日本てんかん学会学術集会  2018.10 

アストロサイトによるシナプス回路構築機構 Invited

繁冨英治

加藤記念研究助成報告交流会  2018.10 

活性化アストロサイトにおけるCa2+シグナルの病態生理学的意義

繁冨英治, 齋藤光象, 小泉修一

平成30年度生理研研究会「シグナル動態の可視化と操作に基づく多階層機能解析の新展開」  2018.9 

Reappearance of astricytic mGluR5 in the primary somatosensory cortex is a cause of neuropathic pain - reassembles of cortical networks -

Danjo, Y., Hirayama, Y., Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK., Nabekura, J., Koizumi, S.

2018.9 

Role of microglia in astrogliopahty: a study of Alexander disease model

Shigetomi, E., Kobayashi, K., Saito, K., Koizumi, S

第61回日本神経化学会大会  2018.9 

Adenosine A2B受容体を介したアストロサイトのmGluR5の発現制御機構

田中雅彬、繁冨英治、パラジュリ・ビージェイ、篠崎陽一、平山友里、斎藤光象、鍋倉淳一、小泉修一

生体機能と創薬シンポジウム2018  2018.8 

Dynamic interaction of neurons and astrocytes revealed dual color Ca2+ imaging. International conference

Shigetomi, E., Hirayama, Y., Ikenaka, K., Tanaka, FK., Bito, H., Koizumi, S. Dynamic interaction of neurons and astrocytes revealed dual color Ca2+ imaging.

2018.7 

Contribution of activated glial cells in epileptogenesis after status epilepticus. International conference

Sano, F., Shigetomi, E., Koizumi, S., Kanemaru, H., Mikoshiba, K., Aihara, M.

WCP2018  2018.7 

nti-depressant flupoxetine reveals its therapeutic effect via astrocytes. International conference

Kinoshita, M., Hirayama, Y., Fujishita, K., Shibata, K., Shinozaki, Y., Shijetomi, E., Takeda, A., Ngoc, Le HP., Hiasa, M., Moriyama, Y., Ikenaka, K., Tanaka, FK., Koizumi, S.

WCP2018  2018.7 

The dysfunction of clock genes induces nocturia associated with disrupted gene expressin rhythm of mechano-sensory channels in the mouse bladder urothelium. International conference

Ihra, T., Nakamura, Y., Shigetomi, E., Shinozaki, Y., Nakao, A., Takeda, M., Koizumi, S.

WCP2018  2018.7 

An essential role of astrocytic mGluR5 in the somatosensory cortex in regulation of synaptogenesis and neuropathic pain. International conference

Danjo, Y., Hirayama, Y., Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK, Nabekura, J., Koizumi, S.

WCP2018  2018.7 

Mechanisms underlying down-regulaton of mGluR5 in astrocytes with ages. International conference

Tanaka, M., Shigetomi, E., Parajuli, B., Shinozaki, Y., Hirayama, Y., Sitoh, K., Nabekura, J., Koizumi, S.

WCP2018  2018.7 

Dynamic interaction of neurons and astrocytes revealed dual color Ca2+ imaging. International conference

Shigetomi, E., Hirayama, Y., Ikenaka, K., Tanaka, FK, Bito, H., Koizumi, S.

WCP2018  2018.7 

Aberrant astrocyte Ca2+ signals ‘AxCa signals’ exacerbate pathological alterations in an Alexander disease model. International conference

Saito, K., Shigetomi, E., Yasuda, R., Sato, R., Tanaka, KF., Mikoshiba, K., Mizuta, I., Yoshida, T., Mizuno, T., Koizumi, S.

WCP2018  2018.7 

Microglial VNUT derived ATP mediates astrogliosis-dependent epileptogenesis after status epilepticus.

佐野史和、繁冨英治、小泉修一、金村英秋、池中一裕、田中謙二、相原正男

第60回日本小児神経学会学術集会  2018.5 

Visualization of spatiotemporal Ca2+ dynamics in astrocyte-neuron interaction

Yukiho Hirayama, Eiji Shigetomi, Kazuhiro Ikenaka, Kenji F Tanaka, Haruhiko Bito, Schuichi Koizumi

2018.3 

脳の高次機能解明に向けた脳神経系細胞の近接場光イメージング

櫻井杏梨，酒井優，篠崎陽一，繁冨英治，小泉修一，居島薫，堀裕和、小林潔

第65回応用物理学会春季学術講演会  2018.3 

Mechanisms underlying down-regulation of mGluR5 in astrocytes with ages International conference

Masayoshi Tanaka, Eiji Shigetomi, Bijay Parajuli, Youichi Shinozaki, Yuri Hirayama, Kozo Saito, Junichi Nabekura, Schuichi Koizumi

The first international symposium for frontend brain science: University of Yamanashi  2018.2 

How do astrocytes sense neuronal information via P2Y1 receptor? International conference

Eiji Shigetomi, Yukiho J Hirayama, Kazuhiro Ikenaka, Kenji F Tanaka, Schuichi Koizumi

The first international symposium for frontend brain science: University of Yamanashi  2018.2 

Functional role of P2Y1 receptor-mediated Ca2+ waves in neuronal Ca2+ signals International conference

Yukiho J Hirayama, Eiji Shigetomi, Kazuhiro Ikenaka, Kenji F Tanaka, Haruhiko Bito, Schuichi Koizumi

The first international symposium for frontend brain science: University of Yamanashi  2018.2 

難治性神経変性疾患「アレキサンダー病」の原因分子を発見

2018.2 

アストロサイトCa2+シグナルの時空間的多様性と その機能的意義

繁冨英治、平山幸歩、齋藤光象、小泉修一

第3回CREST合同ミーティング  2018.2 

Role of P2Y1 receptor in astrocyte-neuron interaction International conference

Eiji Shigetomi, Yukiho J Hirayama, Kazuhiro Ikenaka, Kenji F Tanaka, Haruhiko Bito, Schuichi Koizumi

The fifth symposium and group meeting of glia-assembly.  2018.1 

Acute microglial activation phenotype after status epilepticus: role of microglial vesicular nucleotide transporter in epileptogenesis

Fumikazu Sano, Eiji Shigetomi, Schuichi Koizumi, Hideaki Kanemura, Kazuhiro Ikenaka, Kenji F. Tanakad, Kanji Sugita, Masao Aihara

2017.11 

脳の高次機能の解明に向けた脳神経系の近接場光イメージング

櫻井杏梨，酒井優，篠崎陽一，柴田圭輔，繁冨英治，小泉修一，居島薫，堀裕和、小林潔

ナノオプティクス研究グループ第24回研究討論会  2017.11 

アストロサイト微細突起Ca2+シグナルにおけるP2Y1受容体の役割

繁冨英治、平山幸歩、小泉修一

第137回日本薬理学会関東部会  2017.10 

グリア細胞とシナプスの近接場光学顕微鏡観察（Ⅲ）

櫻井杏梨，酒井優，篠崎陽一，柴田圭輔，繁冨英治，小泉修一，居島薫，堀裕和、小林潔

第78回応用物理学会秋季学術講演会  2017.9 

When do astrocytes listen to ATP derived from neurons? International conference Major achievement

Neuroscience 2017  2017.7 

アストロサイトCa2+シグナルの時空間ダイナミクスの多様性と脳機能制御

繁冨　英治

2017.7  山本　清文

アストロサイトCa2+シグナルの時空間ダイナミクスの多様性と脳機能 Invited Major achievement

繁冨英治、平山幸歩、齋藤光象、小泉修一

新学術領域「グリアアセンブリ」第4回夏のワークショップ  2017.6 

Microglial VNUT contribute to epileptogenesis including astrogliosis after status epilepticus

Fumikazu Sano, Eiji Shigetomi, Schuichi Koizumi, Hideaki Kanemura, Kazuhiro Ikenaka, Kenji F. Tanaka, Kanji Sugita, Masao Aihara.

2017.6 

Enhanced astrocytic Ca2+ signals via IP3R2 contribute to epileptogenesis after status epilepticus. International conference

Fumikazu Sano, Eiji Shigetomi, Schuichi Koizumi, Hideaki Kanemura, Kanji Sugita, Katsuhiko Mikoshiba, Masao Aihara.

14th Asian and Oceanian Congress of Child Neurology  2017.5 

Frontier of glaucoma research; the latest molecular pathogenesis and strategies.

The 90th Annual Meeting of the Japanese Pharmacological society  2017.3 

An increase in extracellular ATP within the somatosensory cortex triggers astrocyte-mediated synapse-remodeling and mechanical allodynia

The 90th Annual Meeting of the Japanese Pharmacological society  2017.3 

Aberrant Ca2+ signals in astrocytes by overexpression of P2Y1 receptors and its effect on neuronal activities Major achievement

The 90th Annual Meeting of the Japanese Pharmacological society  2017.3 

A molecular mechanism underlying astrocyte-mediated synapse-remodeling by ATP in the somatosensory cortex

The 90th Annual Meeting of the Japanese Pharmacological society  2017.3 

Upregulation of mGluR5 in astrocytes in the somatosensory cortex controls induction of mechanical allodynia.

The 90th Annual Meeting of the Japanese Pharmacological society  2017.3 

Clock genes regulate circadian rhythm of VNUT and Connesin 26 expressions and ATP release after stretch stimulate in the cultured urothelial cells Major achievement

2016 The 11th Pan-Pacific Continence Society (PPCS) Annual Meeting  2016.10 

Contributions of reactive astrocytes triggered by microglia to epileptogenesis following status epilepticus.

第50回日本てんかん学会学術集会  2016.10 

Increased neuronal excitability by genetic manipulation of astrocytic Ca2+ signals. International conference Major achievement

第39回日本神経科学大会  2016.7 

アストロサイトGqPCR過剰発現による神経過興奮 Major achievement

第46回日本神経精神薬理学会年会  2016.7 

Clock Genes Regulate Circadian Rhythm of Vnut Expression, Connexin26 Expression and Stretch-Evoked ATP Release in the Cultured Urothelial Cells International conference

The 112th Annual Meeting of the American Urological Association  2016.5 

Role of P2Y1-mediated Ca2+ signals of astrocytes in neuronal excitability Major achievement

The 93rd annual Meeting of the physiological Society of Japan  2016.3 

Clock genes regulate circadian rhythm of Piazo1 and TRPV4 expressions and intracellular Ca2+influx after strech simulation in the cultured urothelial cells International conference Major achievement

31st Annual EAU Congress  2016.3 

Manipulation of astrocyte network by P2Y1 receptor and its impact on neuronal network. Major achievement

The 89th Annual Meeting of the Japanese Pharmacological Society  2016.3 

Astrocytic purinergic signaling controls neuronal networks in the primary somatosensory cortex

The 89th Annual Meeting of the Japanese Pharmacological Society  2016.3 

グリア細胞とシナプスの近接場光学顕微鏡観察

日本光学会ナノオプティクス研究グループ第22回研究討論会  2016.3 

Astrocyte calcium signals and its impact on brain functions. International conference Major achievement

International Postgraduate Conference on Pharmaceutical Science (iPoPS 2016)  2016.2 

アストロサイト微細構造のCa2+動態解析技術 Major achievement

日本顕微鏡会年会第40回関東支部講演会  2016.2 

P2Y1受容体を用いたアストロサイト機能の操作 Major achievement

第133回日本薬理学会関東部会  2015.10 

グリア細胞の機能解明へ向けたシナプス領域の近接場イメージング

第76回応用物理学会秋季学術講演会  2015.9 

Glial assembly:gliotransmission and pathophysiological consequences

The 58th Annual Meeting of the Japanese Society for Neurochemistry  2015.9 

Muller cell regulates axon elongation of retinal ganglion cells via P2Y6 receptor signals Major achievement

The 58th Annual Meeting of the Japanese Society for Neurochemistry  2015.9 

Calcium signals in astrocyte processes:its visualization and manipulation. Major achievement

The 58th Annual Meeting of the Japanese Society for Neurochemistry  2015.9 

A transgenic approach to analyze functions of astrocytic GqPCRs in pathophysiology International conference Major achievement

New insights into glia-mediated ischemic tolerance  2015.7 

Diversity of calcium signals in astrocytes Major achievement

The 2nd meeting of 'Glial Assembly' for young scientist  2015.7 

ﾏｳｽ膀胱平滑筋・上皮におけるP2Y6受容体機能の検討

吉良　聡,芳山　充晴,宮本　達也,井原　達矢,中込　宙史,望月　勉,澤田　智史,柴田　圭輔,繁冨　英治,小泉　修一,武田　正之

第103回日本泌尿器科学会総会  2015.4 

Visualization and manipulation of Ca2+ excitability of astrocytes at interface of synapses Major achievement

The 88th Annual Meeting of The Japanese Pharmacological Society  2015.3 

Astrocyte assembly: a new technology for analysis of its function

第57回日本神経化学会大会・第36回日本生物学的精神医学会合同大会  2014.9 

P2Y6受容体の膀胱機能に関する研究

吉良　聡,芳山　充晴,宮本　達也,井原　達矢,中込　宙史,望月　勉,柴田　圭輔,繁冨　英治,小泉　修一,武田　正之

第21回日本排尿機能学会  2014.9 

GECIによるアウトロサイト局所Ca2+シグナルの可視化 Major achievement

繁冨　英治,小泉　修一

第130回日本薬理学会関東部会  2014.7 

Purinergic transmission via P2Y6 receptor plays an essential role in bladder storage function in mice. Major achievement

29th Annual EAU Congress  2014.4 

P2Y6 receptors plays a critical role in bladder storage function in mice Major achievement

The 87th Annual Meeting of The Japanese Pharmacological Society  2014.3 

アストロサイトの局所シグナルと脳機能

第1回甲府脳研究会  2014.3 

アストロサイト局所カルシウムシグナルによる脳機能制御 Major achievement

国立精神・神経医療研究センターセミナー  2014.2 

Genetically encoded calcium indicator によって見えたアストロサイト局所カルシウムシグナルとその生理機能 Major achievement

第2回neurovascular Unit 研究会  2014.1 

新規Ca2+イメージング技術で見えたグリア性シナプス制御 Major achievement

国立精神・神経医療研究センター山梨大学合同シンポジウム  2014.1 

アストロサイトの局所シグナルと脳機能 Major achievement

繁冨　英治,小泉　修一

第15回応用薬理シンポジウム  2013.9 

Calsium dynamics in perisynaptic astrocytes revealed by genetically encoded calcium indicators Major achievement

2013.8 

Properties and its physiological role of P2Y1-mediated calcium signals in astrocytes. International conference Major achievement

Neuro2013  2013.6 

A local calcium influx pathway in astrocytes and its role in synaptic plasticity. Major achievement

The 90th Annual Meeting of Physiological Society of Japan  2013.3 

Localized caicium signals in astrocytes revealed by genetically encoded calcium indicators. Major achievement

The 86th Annual Meeting of The Japanese Pharmacological Society  2013.3 

TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via passive D-serine release International conference Major achievement

Gordon Research Conferences Glial Biology:Functional Interactions among Glia & Neurons  2013.3 

新規膜移行型Ca2+感受性タンパクによるアストロサイトCa2+動態の解析 Major achievement

第1回シナプス再編におけるグリア戦略研究会  2013.2 

アストロサイトによるシナプス伝達調節:新規カルシウム感受性蛍光タンパクによる解析 Major achievement

繁冨　英治

第28回山梨神経科学研究会  2012.11 

TRPA1 channel-mediated calcium entry in astrocytes revealed by membrane targeted genetically encoded caicium indicator. International conference Major achievement

Neuroscience 2012  2012.9 

P2Y1受容体はアストロサイト細胞移動及び瘢痕様構造の形成を負に調節する

篠﨑　陽一,井村　誉史雄,森澤　陽介,平山　友里,小松　龍平,柴田　圭輔,藤下　加代子,繁冨　英治,小泉　修一

第14回応用薬理シンポジウム  2012.9 

アストロサイトにおける新規局所Ca2+流入経路 Major achievement

繁冨　英治,Baljit Khakh

第14回応用薬理シンポジウム  2012.9 

Novel Ca2+ influx pathway in astrocytes revealed by membrane-targeted genetically encoded Ca2+ indicator Major achievement

2012.8 

アストロサイトにおけるTRPA1チャネルを介した局所カルシウムシグナルとその生理的意義 Major achievement

繁冨　英治,Xiaoping Tong,Baljit S. Khakh

第8回TRPチャネル研究会  2012.6 

A genetically targeted optical sensor to monitor calcium signals in astrocyte processes. International conference Major achievement

Purine2012  2012.6 

アストロサイト局所Ca2+動態とその生理学的意義 Major achievement

繁冨　英治

医学研究の基礎を語り合う集い  2012.5 

Novel astrocyte calcium signal and its role in LTP Major achievement

2012.3 

TRPA1 channel-mediated microdomains contribute to resting calcium levels in astrocytes. Major achievement

第85回日本薬理学会年会  2012.3 

13th Promotion Award of the Physiological Society of Japan for Young Scientists

2012.3  

第89回日本生理学会大会 奨励賞

2012.3   日本生理学会  

繁冨　英治

Eighth Annual Distinguished Postdoctoral Fellow in Neuroscience Lecturer of UCLA

2010  

Society for Neuroscience Postdoctoral Trainee Chapter Travel Award

2010  

The American Physiological Society Travel Award for 36th International Congress of Physiological Sciences

2009  

The Yong Investigators Travel Grant for 36th International Congress of Physiological Sciences

2009  

Postdoctoral Travel Award of UCLA Brain Research Institute and Semel Institute for Neuroscience & Human Behavior

2007  

薬理学系統講義

2013Year  Type of subject：Professional education (undergraduate)

薬理学系統講義

2012Year  Type of subject：Professional education (undergraduate)

2019

Type：Achievement of student guidance (Undergraduate)

Number of people receiving guidance ：3people 

2018

Type：Achievement of student guidance (graduate school)

Number of people receiving guidance ：1people 

2018

Type：Achievement of student guidance (Undergraduate)

Number of people receiving guidance ：2people 

2017

Type：Master's （Major B course）dissertations guidance

Number of people receiving guidance ：2people 

2016

Type：Achievement of student guidance (Undergraduate)

Number of people receiving guidance ：2people 

2016

Type：Achievement of student guidance (graduate school)

Number of people receiving guidance ：2people 

2015

Type：Achievement of student guidance (graduate school)

Number of people receiving guidance ：1people 

2015

Type：Undergraduate （Major A course）graduation thesis guidance  Period：12months

Number of people receiving guidance ：1people 

2015

Type：Achievement of student guidance (Undergraduate)

Number of people receiving guidance ：1people 

2014

Type：Thesis doctoral research guidance

Number of people receiving guidance ：1people 

2014

Type：Achievement of student guidance (Undergraduate)

Number of people receiving guidance ：1people 

2014

Type：Achievement of student guidance (graduate school)

Number of people receiving guidance ：2people 

2013

Type：Ph.D. dissertations guidance

Number of people receiving guidance ：1people