Updated on 2024/03/21

写真a

 
Nakajima Kei
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Clinical Medicine (Blood and Medical Oncology) Clinical Assistant Professor
Title
Clinical Assistant Professor

Research History

  • 山梨大学医学部附属病院   腫瘍センター   臨床助教

    2019.4

  • 山梨大学医学部附属病院   腫瘍センター   臨床助教

    2019.4

  • University of Yamanashi (Blood and Medical Oncology Course (Blood and Medical Oncology))   Assistant Professor

    2018.4 - 2019.3

  • University of Yamanashi (Blood and Medical Oncology Course (Blood and Medical Oncology))   血液・腫瘍内科   助教

    2018.4 - 2019.3

  • 山梨大学医学部附属病院   血液・腫瘍内科   医員

    2006.10

  • 山梨大学医学部附属病院   血液・腫瘍内科   医員

    2006.10

  • 財団法人身延山病院   内科   医員

    2006.4 - 2006.9

  • 財団法人身延山病院   内科   医員

    2006.4 - 2006.9

  • 山梨大学医学部附属病院   卒後臨床研修センター

    2004.4 - 2006.3

  • 山梨大学医学部附属病院   卒後臨床研修センター

    2004.4 - 2006.3

▼display all

Education

  • University of Yamanashi

    - 2019.3

      More details

    Country: Japan

  • University of Yamanashi   医学工学総合教育部   先進医療科専攻

    - 2019.3

  • Toyama Medical and Pharmaceutical University

    1998.4 - 2004.3

      More details

    Country: Japan

  • Toyama Medical and Pharmaceutical University   医学部   医学科

    1998.4 - 2004.3

Degree

  • 博士(医学) ( 2019.3   山梨大学 )

  • 医学士 ( 2004.3   富山医科薬科大学 )

Research Areas

  • Life Science / Hematology and medical oncology  / 悪性リンパ腫、骨髄増殖性疾患

  • Life Science / Hematology and medical oncology  / Hematology

Research Interests

  • 低酸素応答/骨髄増殖性疾患/骨髄線維化

  • 悪性リンパ腫 / 解糖系 / へキソキナーゼ / NF-κB / 抗がん剤耐性

  • 悪性リンパ腫 / 解糖系 / へキソキナーゼ / NF-κB / 抗がん剤耐性

  • 低酸素応答/骨髄増殖性疾患/骨髄線維化

Subject of research

  • 骨髄増殖性疾患における骨髄線維化のメカニズム

  • 悪性リンパ腫における解糖系亢進のメカニズム

Research Projects

  • 悪性リンパ腫における腫瘍性糖代謝とNF-κΒ活性化のクロストークの検証

    2019.4 - 2022.3

    独立行政法人日本学術振興会  科学研究費助成事業  若手研究

    中嶌圭

      More details

    Authorship:Principal investigator  Type of fund::Science research expense

  • Hypoxia modulate epigenomic response in MPN cells

    Grant number:24591386  2012.4 - 2015.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    KIRITO Keita, NAKAJIMA Kei, MITSUMORI Toru, NOZAKI Yumi

      More details

    In the present study, we investigated the role of hypoxia on epigenetic gene regulation in cells derived from myeloproliferative neoplasms having active mutant form of JAK2, JAK2V617F. After culture at hypoxic conditions, total level of methylated cytosine levels were changed in the cells.5-hydorxy-methyl cytosine (5-hmC)levels were drastically decreased in SET-2 cells with normal TET2 function. In contrast, 5-hmC levels were not changed during treatment with hypoxia in HEL cells, which lack TET2 gene. We also found that methylation of promoter lesion of Wnt5a gene were decreased after hypoxia treatment. We also confirmed that hypoxia actually induced expression of Wnt5a both at mRNA and protein levels. Our observations suggested that hypoxia could regulate gene expression not only through activation of transcription factor, HIF, but also through modification of epigenomic machinery including TET2.

Papers

  • The chaperone protein GRP78 released from MPN cells increases the expression of lysyl oxidase in a human stromal cell line. Reviewed Major achievement

    Kei Nakajima, Megumi Suzuki, Ichiro Kawashima, Megumi Koshiisi, Takuma Kumagai, Takeo Yamamoto, Masaru Tanaka, Keita Kirito

    Leukemia research   134   107389 - 107389   2023.9

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Impaired function of the endoplasmic stress (ER) response causes numerous pathological conditions, including tissue fibrosis. In the present study, we aimed to determine the pathological role of ER stress response systems in myeloproliferative neoplasms (MPNs). We found increased expression of the chaperone protein glucose-regulated protein (GRP) 78, a central regulator of ER stress, in megakaryocytes from primary myelofibrosis or postessential thrombocythemia myelofibrosis patients. GRP78 was overexpressed in JAK2V617F-harboring cell lines; however, inhibitors of ER stress did not affect the expression levels of GRP78. In contrast, ruxolitinib, a well-known inhibitor of JAK2V617F, clearly blocked GRP78 expression in these cells through downregulation of transcription factor 4 (ATF4). Interestingly, GRP78 was secreted from HEL and SET-2 cells into culture media. Coculture of these cells with HS-5 cells, a human bone marrow stroma-derived cell line, induced enhanced expression of lysyl oxidase (LOX), which mediates cross-linking of collagen fibers and induces tissue fibrosis, in HS-5 cells. An anti-GRP78 neutralizing antibody abrogated LOX elevation; in contrast, recombinant GRP78 protein induced LOX protein expression in HS-5 cells. Our observations suggest that the oncogenic protein JAK2V617F induces overexpression and release of GRP78, which may induce a fibrotic phenotype in surrounding bone marrow stromal cells.

    DOI: 10.1016/j.leukres.2023.107389

    PubMed

  • Clinical characteristics of Japanese patients with myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis Reviewed

    Yoko Edahiro, Tomonori Ochiai, Yoshinori Hashimoto, Soji Morishita, Shuichi Shirane, Tadaaki Inano, Chiho Furuya, Michiaki Koike, Masaaki Noguchi, Kensuke Usuki, Motoaki Shiratsuchi, Kei Nakajima, Eiichi Ohtsuka, Hiroaki Tanaka, Eri Kawata, Mika Nakamae, Yasunori Ueda, Yasuo Aota, Yasumasa Sugita, Shin Ohara, Satoshi Yamasaki, Kohsuke Asagoe, Shuro Yoshida, Jun Yamanouchi, Sayaka Suzuki, Toshinori Kondo, Yuji Kanisawa, Kohtaro Toyama, Hiromi Omura, Daisuke Mizuchi, Sumio Sakamaki, Miki Ando, Norio Komatsu

    International Journal of Hematology   118 ( 1 )   47 - 53   2023.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) is a rare disease, which presents with features of myelodysplastic syndromes with ring sideroblasts and essential thrombocythemia, as well as anemia and marked thrombocytosis. SF3B1 and JAK2 mutations are often found in patients, and are associated with their specific clinical features. This study was a retrospective analysis of 34 Japanese patients with MDS/MPN-RS-T. Median age at diagnosis was 77 (range, 51-88) years, and patients had anemia (median hemoglobin: 9.0 g/dL) and thrombocytosis (median platelet count: 642 × 109/L). Median overall survival was 70 (95% confidence interval: 68-not applicable) months during the median follow-up period of 26 (range: 0-91) months. A JAK2V617F mutation was detected in 46.2% (n = 12) of analyzed patients (n = 26), while an SF3B1 mutation was detected in 87.5% (n = 7) of analyzed patients (n = 8). Like those with myelodysplastic syndromes or myeloproliferative neoplasms, patients often received erythropoiesis-stimulating agents and aspirin to improve anemia and prevent thrombosis. This study, which was the largest to describe the real-world characteristics of Japanese patients with MDS/MPN-RS-T, showed that the patients had similar characteristics to those in western countries.

    DOI: 10.1007/s12185%2D023%2D03592%2D0,-Abstract

    PubMed

  • 同種造血幹細胞移植における低カリウム血症とカリウム補充療法 Reviewed

    川島 一郎, 日向 英人, 中楯 礼人, 細川 恵理子, 坂本 勇磨, 鈴木 潤, 熊谷 拓磨, 輿石 めぐみ, 鈴木 愛, 山本 健夫, 中嶌 圭, 桐戸 敬太

    臨床血液   64 ( 2 )   83 - 90   2023.2

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11406/rinketsu.64.83

  • Presence of bone marrow fibrosis in multiple myeloma may predict extramedullary disease. Reviewed

    Megumi Koshiishi, Ichiro Kawashima, Hideto Hyuga, Ayato Nakadate, Minori Matsuura, Eriko Hosokawa, Yuma Sakamoto, Jun Suzuki, Megumi Suzuki, Takuma Kumagai, Takeo Yamamoto, Kei Nakajima, Masaru Tanaka, Keita Kirito

    International journal of hematology   116 ( 4 )   544 - 552   2022.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    We analyzed the incidence of bone marrow fibrosis in 91 newly diagnosed Japanese multiple myeloma (MM) patients and evaluated the impact of fibrosis on clinical characteristics and therapeutic outcomes. Thirty-four (37%) patients had greater than grade 1 bone marrow fibrosis. The presence of bone marrow fibrosis did not affect laboratory data, the percentage of plasma cells in bone marrow or cytogenetic findings. It also had no significant effect on response to initial treatment, engraftment after autologous hematopoietic stem cell transplantation or overall survival. Interestingly, the incidence of extramedullary disease at diagnosis was significantly higher in patients with bone marrow fibrosis (p = 0.006). Analysis of biological characteristics of MM cells revealed that expression of CD49e, an alpha5/beta1 integrin, was downregulated in MM cells derived from patients with bone marrow fibrosis (p = 0.026). When seven of the original 34 patients were re-evaluated for fibrosis grading after treatment, five (71%) showed a reduction in fibrosis. Our present findings suggest that the presence of bone marrow fibrosis may predict development of extramedullary disease in MM.

    DOI: 10.1007/s12185-022-03373-1

    PubMed

  • 多彩な自己免疫異常と骨髄線維症を併発した血管免疫芽球性T細胞リンパ腫 Reviewed

    松浦 未乃莉, 輿石 めぐみ, 鈴木 潤, 鈴木 愛, 川島 一郎, 中嶌 圭, 桐戸 敬太 著者情報

    臨床血液   61 ( 2 )   110 - 115   2020

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11406/rinketsu.61.110

    PubMed

  • Glycolytic enzyme hexokinase II is a putative therapeutic target in B-cell malignant lymphoma Reviewed Major achievement

    Nakajima K, Kawashima I, Koshiisi M, Kumagai T, Suzuki M, Suzuki J, Mitsumori T, Kirito K.

    Experimental hematology   78 ( Oct 2019 )   46 - 55   2019.10( ISSN:0301-472X )

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 0.1016/j.exphem.2019.09.023

    PubMed

  • Bone Marrow Invasion of Small Cell Neuroendocrine Carcinoma of the Endometrium: A Diagnostic Pitfall Mimicking a Haematological Malignancy Reviewed

    Ichiro Kawashima, Hiroko Fukasawa, Kazunari Kasai, Takuma Kumagai, Megumi Koshiishi, Kei Nakajima, Tetsuo Kondo, Akihiko Hashi, Shuji Hirata, Keita Kirito

    INTERNAL MEDICINE   58 ( 17 )   2561 - 2568   2019.9( ISSN:0918-2918 )

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.2533-18

    PubMed

  • Molecular response of CSF3R T618I harboring chronic neutrophilic leukemia after induction chemotherapy linked to cord blood transplantation Reviewed

    Kawashima I, Kumagai T, Suzuki M, Suzuki J, Koshiishi M, Nakajima K, Kirito K.

    Ann Hematol   98 ( 9 )   2249 - 2250   2019.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00277-019-03733-8

    PubMed

  • Combined Coagulopathy Can Induce Both Hemorrhagic and Thrombotic Complications in Multiple Myeloma Reviewed

    Ichiro Kawashima, Katsuhiro Takano, Takuma Kumagai, Megumi Koshiishi, Saori Oishi, Yuki Sueki, Kei Nakajima, Toru Mitsumori, Keita Kirito

    INTERNAL MEDICINE   57 ( 22 )   3303 - 3306   2018.11( ISSN:0918-2918 )

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.0915-18

    PubMed

  • Eculizumabが奏効した高齢発症非典型溶血性尿毒症症候群 Reviewed

    深澤 千咲, 大石 沙織, 熊谷 拓磨, 輿石 めぐみ, 末木 侑希, 中嶌 圭, 三森 徹, 吉田 瑶子, 加藤 秀樹, 南学 正臣, 宮田 敏行, 桐戸 敬太

    臨床血液   59 ( 2 )   2018

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11406/rinketsu.59.182

  • Incidence and risk factors of hepatitis B virus reactivation in patients with multiple myeloma in an era with novel agents: a nationwide retrospective study in Japan. Reviewed

    Tsukune Y, Sasaki M, Odajima T, Sunami K, Takei T, Moriuchi Y, Iino M, Isoda A, Nakaya A, Muta T, Miyake T, Miyazaki K, Shimizu T, Nakajima K, Igarashi A, Nagafuji K, Kurihara T, Aoyama T, Sugimori H, Komatsu N.

    Blood Cancer Journal   7 ( 12 )   631   2017.11( ISSN:2044-5385 )

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41408-017-0002-2

    PubMed

  • Tumor Lysis Syndrome after the Administration of Ruxolitinib in a Patient with Post-polycythemia Vera Myelofibrosis Reviewed

    Megumi Koshiishi, Yuki Sueki, Ichiro Kawashima, Kei Nakajima, Toru Mitsumori, Keita Kirito

    INTERNAL MEDICINE   56 ( 17 )   2335 - 2338   2017.9( ISSN:0918-2918 )

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.8706-16

    PubMed

  • 18F-FDG-PET/CTがtriple negative原発性骨髄線維症との鑑別に有効であった骨髄浸潤を伴うびまん性大細胞型B細胞リンパ腫 Reviewed

    熊谷 拓磨, 佐藤 葉子, 輿石 めぐみ, 大石 沙織, 末木 侑希, 中嶌 圭, 三森 徹, 桐戸 敬太

    臨床血液   58 ( 3 )   228 - 232   2017

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11406/rinketsu.58.228

  • Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells. Reviewed

    Experimental hematology   43 ( 7 )   524 - 533   2015.7

     More details

    Language:English  

  • Gastric invasion of multiple myeloma presenting as gastrointestinal bleeding. Reviewed Major achievement

    International journal of hematology   101 ( 6 )   525 - 526   2015.6

     More details

    Authorship:Lead author   Language:English  

  • Cutaneous invasion of leukemia cells during blastic transformation in a post polycythemia vera myelofibrosis patient Reviewed

    International Journal of Hematology   100 ( 6 )   525 - 526   2014.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells. Reviewed

    Toru Mitsumori,Yumi Nozaki,Ichiro Kawashima,Takeo Yamamoto,Yuki Shobu,Kei Nakajima,shoji Morishita,Norio Komatsu,Keita Kirito

    Experimental hematology   42 ( 9 )   783 - 792   2014.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Anaplastic large cell lymphoma with paraneoplastic neutrophilia: an association between IL-17 elevation and aggressive disease progression Reviewed

    Yuki SUEKI,Yumi NOZAKI,Ichiro KAWASHIMA,Takeo YAMAMOTO,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito

    International Journal of Hematology   99 ( 6 )   773 - 776   2014.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • ベンダムスチン単剤療法中にサイトメガロウイルス抗原血症をきたした難治低悪性度B細胞性リンパ腫の3例 Major achievement

    三森 徹,末木 侑希,川島 一郎,山本 健夫,野﨑 由美,中嶌 圭,桐戸 敬太

    臨床血液   55 ( 2 )   239 - 243   2014.2

     More details

    Language:Japanese  

  • Picture in Clinical Hematology(No.66) 骨髄生検がALアミロイドーシスの診断に有用であったBJPλ型多発性骨髄腫 Major achievement

    中嶌 圭,山本 健夫,三森 徹,野﨑 由美,末木 侑希,川島 一郎,桐戸 敬太,一條 昌志,小林 哲郎,大石 直輝,中澤 匡男,加藤 良平

    臨床血液   54 ( 8 )   689 - 689   2013.8

     More details

    Language:Japanese  

  • 化学療法中に生じた非外傷性脾臓破裂を緊急摘脾で救命し得た芽球性形質細胞様樹状細胞腫瘍 Major achievement

    川島 一郎,末木 侑希,山本 健夫,濱中 聡至,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太

    臨床血液   54 ( 6 )   584 - 586   2013.6

     More details

    Language:Japanese  

  • Picture in Clinical Hematology(No.61) ATRA内服中にSweet病を併発した急性前骨髄球性白血病 Major achievement

    末木 侑希,川島 一郎,三森 徹,山本 健夫,濱中 聡至,野﨑 由美,中嶌 圭,桐戸 敬太,花輪 書絵,島田 眞路,井上 朋大,中澤 匡男

    臨床血液   54 ( 3 )   261 - 261   2013.3

     More details

    Language:Japanese  

  • 多発性髄外腫瘤で発症したMLL遺伝子再構成を伴う混合形質性急性白血病 Major achievement

    川島 一郎,菖蒲 侑希,山本 健夫,濱中 聡至,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太

    臨床血液   54 ( 3 )   290 - 294   2013.3

     More details

    Language:Japanese  

  • 重篤な乳酸アシドーシスを合併したびまん性大細胞型B細胞性リンパ腫 Major achievement

    野﨑 由美,三森 徹,中嶌 圭,岩尾 憲明,山本 健夫,西山 真由美,中澤 正樹,小松 則夫,桐戸 敬太

    山梨医科学雑誌   26 ( 1 )   23 - 28   2013.1

     More details

    Language:Japanese  

  • 重篤な乳酸アシドーシスを合併したびまん性大細胞型B細胞性リンパ腫 Reviewed Major achievement

    野﨑 由美,三森 徹,中嶌 圭,岩尾 憲明,山本 健夫,西山 真由美,中澤 正樹,小松 則夫,桐戸 敬太

    山梨医科学誌   26 ( 1 )   23 - 28   2012.1

     More details

    Language:Japanese  

▼display all

Books and Other Publications

  • 骨髄増殖性腫瘍合併妊娠のマネジメント

    中嶌圭( Role: Joint Work)

    科学評論社  2022.8 

     More details

    Responsible for pages:173-178   Language:Japanese   Book type:Scholarly book

Presentations

  • ER stress-induced transcription factor ATF4 is activated in MPN cells

    Kei Nakajima,Keita Kirito

    JSH2021  2021.9  JSH

     More details

    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation(general)  

  • Efficacy of rasburicase in patients with multiple myeloma who received bortezomib based chemotherapy International conference

    2021.2 

     More details

    Event date: 2021.2

    Language:Japanese   Presentation type:Poster presentation  

  • Aberrant regulation of extracellular matrix homeostasis by JAK2V617F Major achievement

    Kei Nakajima, Keita Kirito

    JSH2020   2020.10  Japanese society of hematology

     More details

    Event date: 2020.10

    Language:English   Presentation type:Poster presentation  

  • Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-1 International conference Major achievement

    Kei Nakajima, Keita Kirito, Ichiro Kawashima, Megumi Koshiishi, Takuma Kumagai and Toru Mitsumori

    ASH annual meeting 2017  2017.12  American society of hematology

     More details

    Event date: 2017.12

    Language:English   Presentation type:Poster presentation  

    Venue:Atlanta,GA,USA  

  • Panobinostat reverses hypoxia-induced hexokinase2- dependent cisplatin resistance in lymphoma cells Major achievement

    Kei Nakajima,Takuma Kumagai,Megumi Koshiishi,Saori Ohishi, Yuki Sueki,Ichiro Kawashima,Toru Mitsumori,Keita Kirito

    JSH2017  2017.10 

     More details

    Event date: 2017.10

    Language:English   Presentation type:Poster presentation  

  • Panobinostat reverses hypoxia-induced hexokinase2- dependent cisplatin resistance in lymphoma cells

    Kei Nakajima, Takuma Kumagai, Megumi Koshiishi, Saori Ohishi, Yuki Sueki, Ichiro Kawashima, Toru Mitsumori, Keita Kirito

    JSH2017  2017.10  日本血液学会

     More details

    Language:English   Presentation type:Poster presentation  

    Venue:東京  

  • 当院における、びまん性大細胞型B細胞性リンパ腫に対する喫煙の影響(ポスター) Major achievement

    三森 徹,野﨑 由美,川島 一郎,末木 侑希,中嶌 圭,輿石 めぐみ,桐戸 敬太

    第13回日本臨床腫瘍学会学術集会  2015.7 

     More details

    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:北海道  

  • 副腎血管内大細胞型B細胞性リンパ腫1例 Major achievement

    輿石 めぐみ,熊谷 拓磨,大石 沙織,末木 侑希,川島 一郎,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太

    第3回日本血液学会関東甲信越地方会  2015.7 

     More details

    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:茨城県  

  • Vascular complications of japanese MPN patients undergoing surgery: a single institution's experience(ポスター) Major achievement

    Yuki Sueki,Megumi Koshiishi,Ichiro Kawashima,Takeo Yamamoto,Yumi Nozaki,Kei Nakajima,Toru Mitsumori,Keita Kirito

    第76回日本血液学会学術集会  2014.10 

     More details

    Event date: 2014.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:大阪国際会議場  

  • Successful treatment of DLBCL complicated by cardiac involvement(ポスター) Major achievement

    Aya Sugimura,Yuki Sueki,Ichiro Kawashima,Takeo Yamamoto,Yumi Nozaki,Kei Nakajima,Toru Mitsumori,Keita Kirito

    第76回日本血液学会学術集会  2014.10 

     More details

    Event date: 2014.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:大阪国際会議場  

  • Cytogenetic studies of polycythemia vera; the possible role of trisomy 9 in vascular events(ポスター) Major achievement

    Yuki SUEKI,Takeo YAMAMOTO,Ichiro KAWASHIMA,Yumi NOZAKI,Satoshi HAMANAKA,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito

    第75回日本血液学会学術集会  2013.10 

     More details

    Event date: 2013.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:札幌市  

  • A critical function for SHP2 in JAK positive myeloproliferative neoplasmas(ポスター) Major achievement

    Toru MITSUMORI,Yumi NOZAKI,Yuki SUEKI,Ichiro KAWASHIMA,Takeo YAMAMOTO,Kei NAKAJIMA,Keita Kirito

    第75回日本血液学会学術集会  2013.10 

     More details

    Event date: 2013.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:札幌市  

  • 当院にて経験した治療関連骨髄性腫瘍の検討(ポスター) Major achievement

    三森 徹,末木 侑希,川島 一郎,山本 健夫,野﨑 由美,中嶌 圭,桐戸 敬太

    第11回日本臨床腫瘍学会学術集会  2013.8 

     More details

    Event date: 2013.8

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:仙台市  

  • 著明なNa血症を伴う中枢性塩類喪失症候群(CSWS)で発症したびまん性大細胞型B細胞性リンパ腫 Major achievement

    成澤宏宗,川島 一郎,末木 侑希,山本 健夫,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太

    日本血液学会第170回例会  2013.7 

     More details

    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:日内会館4階会議室  

  • 血球貧食症候群を伴う不明熱として発症したALK陽性大型B細胞性リンパ腫 Major achievement

    川島 一郎,末木 侑希,山本 健夫,濱中 聡至,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太

    第169回日本血液学会例会  2013.2 

     More details

    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:NTT東日本関東病院  

  • Metformin restores LKB-1/AMPK function via the inhibition of ERK in leukemia cells(ポスター) Major achievement

    Ichiro KAWASHIMA,Yumi NOZAKI,Yuki SUEKI,Takeo YAMAMOTO,Satoshi HAMANAKA,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito

    第74回日本血液学会学術集会  2012.10 

     More details

    Event date: 2012.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:国立京都国際会館  

  • 低酸素環境はMPN細胞のエピジェネティックな遺伝子応答を改変する(ポスター) Major achievement

    中嶌 圭,三宅 邦夫,川島 一郎,野﨑 由美,山本 健夫,濱中 聡至,三森 徹,久保田 健夫,桐戸 敬太

    第74回日本血液学会学術集会  2012.10 

     More details

    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:国立京都国際会館  

  • Two cases of atypical myeloid leukemia with abnormalities chromosome 21(ポスター) Major achievement

    Takeo YAMAMOTO,Ichiro KAWASHIMA,Yuki SUEKI,Satoshi HAMANAKA,Yumi NOZAKI,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito

    第74回日本血液学会学術集会  2012.10 

     More details

    Event date: 2012.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:国立京都国際会館  

  • 随外腫瘤を多発したMLL遺伝子再構成を伴う混合形質性急性白血病の1例 Major achievement

    川島 一郎,三森 徹,中嶌 圭,野﨑 由美,山本 健夫,濱中 聡至,桐戸 敬太

    第168回日本血液学会例会  2012.7 

     More details

    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:東京慈恵会医科大学  

  • Bendamusutine単剤療法にてサイトメガロウイルスの再活性化を来たした再発・難治低悪性B細胞性リンパ腫の症例 Major achievement

    三森 徹,野﨑 由美,川島 一郎,山本 健夫,濱中 聡至,中嶌 圭,桐戸 敬太

    第10回日本臨床腫瘍学会学術集会  2012.7 

     More details

    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:大阪国際会議場  

  • 性赤血球増加症における血栓症のリスク解析(ポスター) Major achievement

    山本 健夫,三森 徹,川島 一郎,濱中 聡至,野﨑 由美,中嶌 圭,小松 則夫,桐戸 敬太

    第73回日本血液学会学術集  2011.10 

     More details

    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:名古屋国際会議場  

  • レナリドマイド投与後に亜急性甲状腺炎を発症した5q-症候群の1例 Major achievement

    末木 侑希,三森 徹,山本 健夫,濱中 聡至,野﨑 由美,中嶌 圭,桐戸 敬太

    第166回日本血液学会例会  2011.7 

     More details

    Event date: 2011.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:日内会館  

  • 若年発症の菌状息肉症(腫瘍期)の一例 Major achievement

    篠田 大輔,三森 徹,永嶋 貴博,中嶌 圭,野﨑 由美,濱中 聡至,桐戸 敬太

    第574回日本内科学会関東地方会例会  2010.9 

     More details

    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:日内会館4階会議室  

  • 膵癌が疑われた膵臓原発の髄外性形質細胞腫の1例 Major achievement

    沼田 裕樹,小佐野 雅識,川島 一郎,中嶌 圭,野﨑 由美,山本 健夫,三森 徹,小松 則夫,桐戸 敬太

    第573回日本内科学会関東地方会例  2010.7 

     More details

    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:日本都市センター(東京都)  

  • たこつぼ型心筋症を発症した多発性骨髄腫 Major achievement

    三森 徹,中嶌 圭,野﨑 由美,濱中 聡至,永嶋 貴博,岩尾 憲明,桐戸 敬太,小松 則夫

    第71回日本血液学会総会  2009.10 

     More details

    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:京都府  

▼display all

Teaching Experience (On-campus)

  • 血液・腫瘍内科臨床実習(ACC・BCC)

    2022Year

    臨床実習指導

  • テュートリアル コース4

    2021Year  Type of subject:Professional education (undergraduate)

  • 血液・腫瘍内科臨床実習(ACC・BCC)

    2021Year  Type of subject:Professional education (undergraduate)

  • 血液・腫瘍内科臨床実習(ACC・BCC)

    2020Year  Type of subject:Professional education (undergraduate)

Guidance results

  • 2022

    Type:Achievement of hospital training physicians guidance  Year guidance time:150hours

    Number of people receiving guidance :15people 

  • 2021

    Type:Achievement of hospital training physicians guidance  Period:12months

    Number of people receiving guidance :11people 

  • 2021

    Type:Achievement of student guidance (graduate school)

    Number of people receiving guidance :1people 

Other undergraduate student guidance

  • 2021

    Hospital clinical training - total time:200hours

Other educational achievements

  • 試験監督、OSCE評価者

    2021

  • 大学入試共通テスト試験監督

    2021

  • OSCE試験監督

    2020

  • センター試験 試験監督

    2019

  • 医学部医学科後期試験試験監督

    2019

Professional Memberships

  • 日本造血細胞移植学会

  • 日本内科学会

  • 日本血液学会

  • 日本臨床腫瘍学会

  • 日本造血細胞移植学会

  • 日本血液学会

  • 日本臨床腫瘍学会

  • 日本内科学会

▼display all