Updated on 2024/04/10

写真a

 
Takano Katsuhiro
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine University Hospital (Division of Transfusion Medicine and Cell Therapy) Senior Assistant Professor
Title
Senior Assistant Professor
Homepage
http://www.med.yamanashi.ac.jp/clinical/clin0lab/

Research History

  • University of Yamanashi (Clinical Laboratory and Medicine)

    2016.4

  • 山梨大学助教（医学部附属病院　検査部）

    2010.4

  • 山梨大学助教(臨床検査医学講座)

    2006.9

  • 山梨大学大学院生(臨床検査医学)

  • 山梨大学研究生(臨床検査医学)

Education

  • 東京大学大学院　医学博士課程

    　 More details

    Country： Japan

    Notes： (事項) 東京大学大学院　医学博士課程　修了

  • 信州大学　医学部　

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    Country： Japan

    Notes： (事項) 信州大学　医学部　卒業

Degree

  • PhD

  • M.D.

Research Areas

  • Life Science / Hematology and medical oncology  / 血小板，血栓形成メカニズム

  • Life Science / Hematology and medical oncology  / Platelet, Thrombosis and Hemostasis, Differentiation and Maturation of Megakaryocyte

Research Interests

  • platelet, Megakaryocyte, GP Ib complex, RNA, Aspirin, Protein C system

Subject of research

  • Evaluation of Aspirin-Resistance, Aspirin-Resistance in Diabetic Patients.

  • 血小板 procoagulant 活性，Protein C system，血小板アスピリン耐性

  • Thrombocytepoiesis, Function of GP Ib complex, RNA in Megakaryocyte/platelet,
    Mechanism of platelet activation

Papers

  • C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice Reviewed

    Ryohei Yokomori, Toshiaki Shirai, Nagaharu Tsukiji, Saori Oishi, Tomoyuki Sasaki, Katsuhiro Takano & Katsue Suzuki-Inoue

    PLATELETS   34 ( 1 )   1 - 11   2023.11( ISSN：0953-7104 )

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1080/09537104.2023.2281941

  • AbnormalitiesinC-typelectin-likereceptor2inapatientwith Gorham-Stoutdisease: thefirstcasereport Reviewed

    SaoriOishi, NagaharuTsukiji, TakahiroSegawa, KatsuhiroTakano, NorioHasuda, KatsueSuzuki-Inoue

    Research and Practice in Thrombosis and Haemostasis   8 ( 1 )   1 - 5   2023.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.rpth.2023.102273

  • Cancer-associated fibroblasts promote venous thrombosis through podoplanin/CLEC-2 interaction in podoplanin-negative lung cancer mouse model Reviewed

    Toshiaki Shirai, Nagaharu Tsukiji, Tomoyuki Sasaki, Saori Oishi, Ryohei Yokomori, Katsuhiro Takano, Katsue Suzuki-Inoue

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS   2023.7( ISSN：1538-7933 )

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jtha.2023.07.005.

  • CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice Reviewed

    Shimon Otake, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Shogo Tamura, Katsuhiro Takano, Yukio Ozaki, Katsue Suzuki‐Inoue

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS   19 ( 6 )   1572 - 1584   2021.6( ISSN：1538-7933 )

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Erythropoiesis is a complex multistep process by which erythrocytes are produced. C-type lectin-like receptor 2 (CLEC-2) is a podoplanin (PDPN) receptor almost exclusively expressed on the surface of platelets and megakaryocytes. Deletion of megakaryocyte/platelet CLEC-2 was reported to cause anemia along with thrombocytopenia in mice. PDPN-expressing stromal cells in the bone marrow (BM) were also reported to facilitate megakaryocyte expansion and maturation depending on the CLEC-2/PDPN interaction. OBJECTIVES: We investigated how specific deletion of CLEC-2 in megakaryocytes/platelets leads to anemia. METHODS: We used flow-cytometry to analyze maturation of erythroblasts, apoptotic cell death, and cell cycle distribution. CLEC-2 stimulated PDPN-expressing stromal cell conditioned medium was analyzed by cytokine array and ELISA, and co-cultured with immature erythroblasts. Cytokine levels in serum and BM extracellular fluid were quantified by ELISA. RESULTS: We observed increased apoptosis of BM erythroblasts in megakaryocyte/platelet-specific CLEC-2 conditional knockout (Clec1bΔPLT ) mice. Moreover, PDPN-expressing stromal cells in the BM secreted insulin-like growth factor 1 (IGF-1) depending on the CLEC-2/PDPN interaction. Pretreatment with IGF-1 receptor inhibitor increased apoptosis rate and decreased the proliferation of erythroblasts in vitro. Furthermore, in Clec1bΔPLT mice, IGF-1 concentrations in serum and BM extracellular fluid were decreased, and IGF-1 replacement in Clec1bΔPLT mice attenuated anemia. CONCLUSIONS: Our findings suggest that IGF-1 secretion from PDPN-expressing stromal cells by CLEC-2 stimulation positively regulates erythroblasts. This novel mechanism of erythropoiesis regulation indicates that a microenvironment consisting of megakaryocytes and PDPN-expressing stromal cells supports erythropoiesis.

    DOI： 10.1111/jth.15317

    PubMed

  • Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ Reviewed

    Saori Oishi ,Nagaharu Tsukiji ,Shimon Otake ,Naoki Oishi ,Tomoyuki Sasaki ,Toshiaki Shirai ,Yuri Yoshikawa ,Katsuhiro Takano ,Hideyuki Shinmori ,Takeshi Inukai ,Tetsuo Kondo ,Katsue Suzuki-Inoue

    Blood Advances   5 ( 7 )   2017 - 2026   2021.4( ISSN：2473-9529  eISSN：2473-9537 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Society of Hematology  

    <title>Abstract</title>
    There is increasing evidence that platelets participate in multiple pathophysiological processes other than thrombosis and hemostasis, such as immunity, inflammation, embryonic development, and cancer progression. A recent study revealed that heme (hemin)-activated platelets induce macrophage extracellular traps (METs) and exacerbate rhabdomyolysis-induced acute kidney injury (RAKI); however, how hemin activates platelets remains unclear. Here, we report that both C-type lectin-like receptor-2 (CLEC-2) and glycoprotein VI (GPVI) are platelet hemin receptors and are involved in the exacerbation of RAKI. We investigated hemin-induced platelet aggregation in humans and mice, binding of hemin to CLEC-2 and GPVI, the RAKI-associated phenotype in a mouse model, and in vitro MET formation. Using western blotting and surface plasmon resonance, we showed that hemin activates human platelets by stimulating the phosphorylation of SYK and PLCγ2 and directly binding to both CLEC-2 and GPVI. Furthermore, hemin-induced murine platelet aggregation was partially reduced in CLEC-2–depleted and FcRγ-deficient (equivalent to GPVI-deficient) platelets and almost completely inhibited in CLEC-2–depleted FcRγ-deficient (double-knockout) platelets. In addition, hemin-induced murine platelet aggregation was inhibited by the CLEC-2 inhibitor cobalt hematoporphyrin or GPVI antibody (JAQ-1). Renal dysfunction, tubular injury, and MET formation were attenuated in double-knockout RAKI mice. Furthermore, in vitro MET formation assay showed that the downstream signaling pathway of CLEC-2 and GPVI is involved in MET formation. We propose that both CLEC-2 and GPVI in platelets play an important role in RAKI development.

    DOI： 10.1182/bloodadvances.2020001698

    PubMed

  • Construction of a Highly Accurate Prediction Formula for CD34+ Cell Yield in Peripheral Blood Hematopoietic Stem Cell Harvest. Reviewed

    Japanese Journal of Transfusion and Cell Therapy   65 ( 5 )   793 - 799   2019.10( ISSN：1881-3011 )

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    Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Construction of a Highly Accurate Prediction Formula for CD34+ Cell Yield in Peripheral Blood Hematopoietic Stem Cell Harvest. Reviewed

    樋口浩二, 高野勝弘, 山中浩代, l

    Japanese Journal of Transfusion and Cell Therapy   65 ( 5 )   793 - 799   2019.10( ISSN：1881-3011 )

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Soluble CLEC-2 is generated independently of ADAM10 and is increased in plasma in acute coronary syndrome: comparison with soluble GPVI Reviewed

    Osamu Inoue, Makoto Osada, Junya Nakamura, Fuminori Kazama, Toshiaki Shirai, Nagaharu Tsukiji, Tomoyuki Sasaki, Hiroshi Yokomichi, Tomotaka Dohi, Makoto Kaneko, Makoto Kurano, Mitsuru Oosawa, Shogo Tamura, Kaneo Satoh, Katsuhiro Takano, Katsumi Miyauchi, Hiroyuki Daida, Yutaka Yatomi, Yukio Ozaki, Katsue Suzuki-Inoue

    INTERNATIONAL JOURNAL OF HEMATOLOGY   110 ( 3 )   285 - 294   2019.6( ISSN：0925-5710 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society of Hematology  

    Soluble forms of platelet membrane proteins are released upon platelet activation. We previously reported that soluble C-type lectin-like receptor 2 (sCLEC-2) is released as a shed fragment (Shed CLEC-2) or as a whole molecule associated with platelet microparticles (MP-CLEC-2). In contrast, soluble glycoprotein VI (sGPVI) is released as a shed fragment (Shed GPVI), but not as a microparticle-associated form (MP-GPVI). However, mechanism of sCLEC-2 generation or plasma sCLEC-2 has not been fully elucidated. Experiments using metalloproteinase inhibitors/stimulators revealed that ADAM10/17 induce GPVI shedding, but not CLEC-2 shedding, and that shed CLEC-2 was partially generated by MMP-2. Although MP-GPVI was not generated, it was generated in the presence of the ADAM10 inhibitor. Moreover, antibodies against the cytoplasmic or extracellular domain of GPVI revealed the presence of the GPVI cytoplasmic domain, but not the extracellular domain, in the microparticles. These findings suggest that most of the GPVI on microparticles are induced to shed by ADAM10; MP-GPVI is thus undetected. Plasma sCLEC-2 level was 1/32 of plasma sGPVI level in normal subjects, but both soluble proteins significantly increased in plasma of patients with acute coronary syndrome. Thus, sCLEC-2 and sGPVI are released by different mechanisms and released in vivo upon platelet activation.

    DOI： 10.1007/s12185-019-02680-4

    PubMed

  • 血栓止血の臨床ー研修医のために（第2版） 血小板数の低下する疾患・病態の鑑別 Invited

    高野 勝弘

    日本血栓止血学会誌   29 ( 6 )   612 - 616   2018.12( ISSN：0915-7441 )

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    Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：(MISC) Introduction and explanation (scientific journal)  

  • 血栓止血の臨床ー研修医のために（第2版） 血小板数の低下する疾患・病態の鑑別 Invited

    高野 勝弘

    29 ( 6 )   612 - 616   2018.12( ISSN：0915-7441 )

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    Language：Japanese   Publishing type：(MISC) Introduction and explanation (scientific journal)  

  • Combined Coagulopathy Can Induce Both Hemorrhagic and Thrombotic Complications in Multiple Myeloma. Reviewed

    I Kawashima, K Takano, T Kumagai, M Koshiishi, S Oishi, Y Sueki, K Nakajima, T Mitsumori, K Kirito

    INTERNAL MEDICINE   57 ( 22 )   3303 - 3306   2018.11( ISSN：0918-2918  eISSN：1349-7235 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Internal Medicine  

    DOI： 10.2169/internalmedicine.0915-18

    PubMed

  • Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerisation. Reviewed

    Iwaki T, Nagahashi K, Takano K, Suzuki-Inoue K, Kanayama N, Umemura K, Urano T.

    THROMBOSIS AND HAEMOSTASIS   117 ( 5 )   860 - 869   2017.5( ISSN：0340-6245 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN  

    Serpinopathy is characterised as abnormal accumulation of serine protease inhibitors (SERPINs) in cells and results in clinical symptoms owing to lack of SERPIN function or excessive accumulation of abnormal SERPIN. We recently identified a patient with functional deficiency of plasminogen activator inhibitor-1 (PAI-1), a member of the SERPIN superfamily. The patient exhibited life-threatening bleeding tendencies, which have also been observed in patients with a complete deficiency in PAI-1. Sequence analysis revealed a homozygous singlenucleotide substitution from guanine to cytosine at exon 9, which changed amino acid residue 397 from glycine to arginine (c.1189G&gt;C; p.Gly397Arg). This glycine was located in strand 5B and was well conserved in other serpins. The mutant PAI-1 was polymerised in the cells, interfering with PAI-1 secretion. The corresponding mutations in SERPINC1 (anti-thrombin III) at position 456 (Gly456Arg) and SERPINI1 (neuroserpin) at position 392 (Gly392Glu) caused an anti-thrombin deficiency and severe dementia due to intracellular retention of the polymers. Glycine is the smallest amino acid, and these mutated amino acids were larger and charged. To determine which factors were important, further mutagenesis of PAI-1 was performed. Although the G397A, C, I, L, S, T, and V were secreted, the G397D, E, F, H, K, M, N, P, Q, W, and Y were not secreted. The results revealed that the size was likely triggered by the polymerisation of SEPRINs at this position. Structural analyses of this mutated PAI-1 would be useful to develop a novel PAI-1 inhibitor, which may be applicable in the context of several pathological states.

    DOI： 10.1160/TH16-07-0572

    Web of Science

    PubMed

  • 血栓性素因・出血性素因の診療の進め方 〜血栓症・出血傾向のケースレポートを通して Reviewed

    高野 勝弘

    山梨医科学雑誌   32 ( 1 )   2017

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    Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

  • 血栓性素因・出血性素因の診療の進め方 〜血栓症・出血傾向のケースレポートを通して Reviewed

    高野 勝弘

    山梨医科学雑誌   32 ( 1 )   2017

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    Language：Japanese   Publishing type：(MISC) Introduction and explanation (bulletin of university, research institution)  

  • VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets. Reviewed Major achievement

    Thrombosis Journal   11 ( 23 )   2013.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets. Reviewed

    Kaneo SATOH, Hirayama T, Katsuhiro TAKANO, Katsue SUZUKI-INOUE, Sato T, Masato OTA, Nakagomi J, Yukio OZAKI

    Thrombosis Journal   11 ( 23 )   2013.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Aspirin Half maximal inhibitory concentration value on platelet cyclooxygenase 1 in severe type-2 diabetes mellitus is not significantly different from that of healthy individuals. Reviewed Major achievement

    Clinical and Applied Thrombosis and Hemostasis   2013.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Aspirin Half maximal inhibitory concentration value on platelet cyclooxygenase 1 in severe type-2 diabetes mellitus is not significantly different from that of healthy individuals. Reviewed

    木村 行男, Katsuhiro TAKANO, Kaneo SATOH, Aida K, Kobayashi T, Yukio OZAKI

    Clinical and Applied Thrombosis and Hemostasis   2013.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • 臨床医からの質問に答える 残余血清を用いて追加検査をしたいのですが、主な成分の安定性を教えて下さい Major achievement

    山﨑　浩和,高野　勝弘,尾崎　由基男

    検査と技術   40 ( 8 )   755 - 759   2012.8

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    Language：Japanese   Publishing type：(MISC) Introduction and explanation (scientific journal)  

  • 臨床医からの質問に答える 残余血清を用いて追加検査をしたいのですが、主な成分の安定性を教えて下さい

    山﨑 浩和, 高野 勝弘, 尾崎 由基男

    検査と技術   40 ( 8 )   755 - 759   2012.8

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    Language：Japanese   Publishing type：(MISC) Introduction and explanation (scientific journal)  

  • 【新規経口抗凝固薬の光と影】経口抗凝固薬が必要な病態とその動向 抗凝固薬と抗血小板薬の薬効と適応の差異 Major achievement

    高野　勝弘,尾崎　由基男

    Medicina   49 ( 6 )   957 - 959   2012.6

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    Authorship：Lead author   Language：Japanese   Publishing type：(MISC) Introduction and explanation (scientific journal)  

  • Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells Reviewed Major achievement

    Makoto OSADA,Osamu INOUE,Guo Ding,Toshiaki SHIRAI,Hirotake Ichise,Kazuyoshi HIRAYAMA,Katsuhiro TAKANO,Yutaka YATOMI,Masanori HIRASHIMA,Hideki FUJII,Katsue SUZUKI-INOUE,Yukio OZAKI

    THE JOURNAL OF BIOLOGICAL CHEMISTRY   287 ( 26 )   22241 - 22252   2012.6

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    Language：English   Publishing type：Research paper (scientific journal)  

  • 【新規経口抗凝固薬の光と影】経口抗凝固薬が必要な病態とその動向 抗凝固薬と抗血小板薬の薬効と適応の差異

    高野 勝弘, 尾崎 由基男

    Medicina   49 ( 6 )   957 - 959   2012.6

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    Language：Japanese   Publishing type：(MISC) Introduction and explanation (scientific journal)  

  • Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells Reviewed

    Makoto Osada, Osamu Inoue, Guo Ding, Toshiaki Shirai, Hirotake Ichise, Kazuyoshi Hirayama, Katsuhiro Takano, Yutaka Yatomi, Masanori Hirashima, Hideki Fujii, Katsue Suzuki-Inoue, Yukio Ozaki

    JOURNAL OF BIOLOGICAL CHEMISTRY   287 ( 26 )   22241 - 22252   2012.6( ISSN：0021-9258 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC  

    The platelet activation receptor CLEC-2 plays crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis, although its role in thrombosis/hemostasis remains controversial. An endogenous ligand for CLEC-2, podoplanin, is expressed in lymphatic endothelial cells (LECs). We and others have reported that CLEC-2-deficiency is lethal at mouse embryonic/neonatal stages associated with blood-filled lymphatics, indicating that CLEC-2 is essential for blood/lymphatic vessel separation. However, its mechanism, and whether CLEC-2 in platelets is necessary for this separation, remains unknown. We found that specific deletion of CLEC-2 from platelets leads to the misconnection of blood/lymphatic vessels. CLEC-2(+/+) platelets platelets, but not by CLEC-2(-/-) platelets, inhibited LEC migration, proliferation, and tube formation but had no effect on human umbilical vein endothelial cells. Additionally, supernatants from activated platelets significantly inhibited these three functions in LECs, suggesting that released granule contents regulate blood/lymphatic vessel separation. Bone morphologic protein-9 (BMP-9), which we found to be present in platelets and released upon activation, appears to play a key role in regulating LEC functions. Only BMP-9 inhibited tube formation, although other releasates including transforming growth factor-beta and platelet factor 4 inhibited proliferation and/or migration. We propose that platelets regulate blood/lymphatic vessel separation by inhibiting the proliferation, migration, and tube formation of LECs, mainly because of the release of BMP-9 upon activation by CLEC-2/podoplanin interaction.

    DOI： 10.1074/jbc.M111.329987

    Web of Science

  • 【血栓症診療update-新規経口凝固薬を加えて広がる世界】≪動脈硬化/血栓性疾患と抗血小板療法≫広い市場を獲得した抗血小板薬clopidogrel Major achievement

    高野　勝弘,尾崎　由基男

    内科   110 ( 1 )   41 - 45   2012.1

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    Language：Japanese  

  • 抗血小板薬レジスタンスを検出するための臨床検査の原理と種類 Major achievement

    高野　勝弘

    血栓と循環   18 ( 1 )   25 - 30   2010.3

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    Language：Japanese  

  • 抗血小板療法のモニタリングと薬剤抵抗性

    高野　勝弘,尾崎　由基男

    脳卒中   30   953 - 959   2009.10

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    Language：Japanese  

  • 生体骨髄での血小板産生の観察

    高野　勝弘

    日本血栓止血学会誌   19 ( 6 )   833 - 833   2008.12

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    Language：Japanese  

  • 抗血小板療法のモニタリングと薬剤抵抗性

    高野　勝弘,尾崎　由基男

    脳卒中   30 ( 6 )   953 - 959   2008.11

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    Language：Japanese  

  • 抗血小板剤抵抗性

    高野　勝弘,尾崎　由基男

    BIO Clinica   23 ( 10 )   38 - 42   2008.8

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    Language：Japanese  

  • 特機的な経皮的冠動脈インターベンション(PCI)における低分子量ヘパリン(enoxaparin)と未分画ヘパリンの安定性の比較

    高野　勝弘

    血栓と循環   15 ( 4 )   385 - 393   2007.12

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    Language：Japanese  

  • Efficient expression of a transgene in platelets using simian immunodeficiency virus-based vector harboring glycoprotein Ibalpha promoter: in vivo model for platelet-targeting gene therapy. Reviewed

    Ohmori T,Mimuro J,Takano K,Madoiwa S,Kashiwakura Y,その他７名

    FASEB Journal   20 ( 9 )   1522 - 1524   2006.7

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  • Efficient expression of a transgene in platelets using simian immunodeficiency virus-based vector harboring glycoprotein Ib alpha promoter: in vivo model for platelet-targeting gene therapy Reviewed

    Tsukasa Ohmori, Jun Mimuro, Katsuhiro Takano, Seiji Madoiwa, Yuji Kashiwakura, Akira Ishiwata, Masanori Niimura, Katsuyuki Mitomo, Toshiaki Tabata, Mamoru Hasegawa, Keiya Ozawa, Yoichi Sakata

    FASEB JOURNAL   20 ( 9 )   1522 - +   2006.7( ISSN：0892-6638 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：FEDERATION AMER SOC EXP BIOL  

    Platelets release several mediators that modify vascular integrity and hemostasis. In the present study, we developed a technique for efficient transgene expression in platelets in vivo and examined whether this targeted-gene-product delivery system using a platelet release reaction could be exploited for clinical applications. Analysis of luciferase reporter gene constructs driven by platelet-specific promoters (the GPIIb, GPIb alpha, and GPVI) revealed that the GPIb alpha promoter was the most potent in the megakaryoblastic cell line UT-7/TPO and human CD34(+)-derived megakaryocytes. Transduction of UT-7/TPO; CD34(+)-derived megakaryocytes; and c-Kit(+), ScaI(+), and Lineage(-) (KSL) murine hematopoietic stem cells with a simian immunodeficiency virus (SIV)-based lentiviral vector carrying eGFP resulted in efficient, dose-dependent expression of eGFP, and the GPIb alpha promoter seemed to bestow megakaryocytic-specific expression. Transplantation of KSL cells transduced with SIV vector containing eGFP into mice showed that there was preferable expression of eGFP in platelets driven by the GPIb alpha promoter [7-11% for the cytomeglovirus (CMV) promoter, 16-27% for the GPIb alpha promoter]. Furthermore, transplantation of ex vivo-transduced KSL cells by SIV vector carrying human factorVIII (hFVIII) driven by the GPIb alpha promoter induced the production of detectable transcripts of the hFVIII gene and the hFVIII antigen in bone marrow and spleen for at least 90 days and partially corrected the hemophilia A phenotype. Platelet-targeting gene therapy using SIV vectors appears to be promising for gene therapy approaches toward not only inherited platelet diseases but also other hemorrhagic disorders such as hemophilia A.

    DOI： 10.1096/10.1096/fj.05-5161fje

    Web of Science

  • Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: Its correlation to development of renal failure. Reviewed

    Ono T,Mimuro J,Madoiwa S,Soejima K,Kashiwakura Y,その他４名

    Blood   107 ( 2 )   528 - 534   2006.1

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  • Phenotype correction of hemophilia A mice with adeno-associated virus vectors carrying the B domain-deleted canine factor VIII gene. Reviewed

    Ishiwata A,Mimuro J,Kashiwakura Y,Niimura M,Takano K,その他８名

    Thrombosis Research   118 ( 5 )   627 - 635   2006.1

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  • Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: Its correlation to development of renal failure. Reviewed

    Ono T, Mimuro J, Madoiwa S, Soejima K, Kashiwakura Y, の

    Blood   107 ( 2 )   528 - 534   2006.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Impact Factor: 10.131

  • Phenotype correction of hemophilia A mice with adeno-associated virus vectors carrying the B domain-deleted canine factor VIII gene Reviewed

    Akira Ishiwata, Jun Mimuro, Yuji Kashiwakura, Masanori Niimura, Katsuhiro Takano, Tsukasa Ohmori, Seiji Madoiwa, Hiroaki Mizukami, Takashi Okada, Hiroyuki Naka, Akira Yoshioka, Keiya Ozawa, Yoichi Sakata

    THROMBOSIS RESEARCH   118 ( 5 )   627 - 635   2006( ISSN：0049-3848 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

    Adeno-associated virus (AAV) vectors carrying the B domain-deleted canine FVIII (BDD cFVIII) gene utilizing the beta-actin minimum promoter (167b) pseudotyped with serotype 1 (AAV1-beta-actin-cFVIII) and serotype 8 (AAV8-beta-actin-cFVIII) were developed to express cFVIII in hemophilia A mice. FVIII clotting activities measured by the APTT method increased in hemophilia A mice with intramuscular injection of AAV1-beta-actin-cFVIII in a dose-dependent manner. Therapeutic FVIII levels (2.9 +/- 1.0%) in hemophilia A mice with the AAV1-beta-actin-cFVIII dose of 1x10(12) gc/body were achieved, suggesting partial correction of the phenotype with AAV1-beta-actin-cFVIII vectors. FVIII clotting activity levels in hemophilia A mice with intravenous injection of AAV8-beta-actin-cFVIII also were increased dose-dependently, achieving therapeutic FVIII levels (5-90%) in hemophilia A mice with the AAV8-beta-actin-cFVIII doses of 1-3 x 10(11) gc/body and supernormal FVIII levels (180-670%) in hemophilia A mice with the AAV8-beta-actin-cFVIII dose of 1 x 10(12) gc/body. Transduction of the liver with AAV8-beta-actin-cFVIII is superior to transduction of skeletal muscles with AAV1cFVIII regarding the FVIII production and antibody formation. These data suggested that both AM and AAV8 vectors carrying the FVIII gene utilizing a minimum promoter have a potential for hemophilia A gene therapy. (c) 2005 Elsevier Ltd. All rights reserved.

    DOI： 10.1016/j.thromres.2005.11.006

    Web of Science

  • Sustained transgene expression by human cord blood derived CD34(+) cells transduced with simian immunodeficiency virus agmTYO1-based vectors carrying the human coagulation factor VIII gene in NOD/SCID mice. Reviewed

    Kikuchi J,Mimuro J,Ogata K,Tabata T,Ueda Y,その他１０名

    J Gene Med   6 ( 10 )   1049 - 1060   2004.10

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Sustained transgene expression by human cord blood derived CD34+ cells transduced with simian immunodeficiency virus agmTYO(1)-based vectors carrying the human coagulation factor VIII gene in NOD/SCID mice Reviewed

    J Kikuchi, J Mimuro, K Ogata, T Tabata, Y Ueda, A Ishiwata, K Kimura, K Takano, S Madoiwa, H Mizukami, Y Hanazono, A Kume, M Hasegawa, K Ozawa, Y Sakata

    JOURNAL OF GENE MEDICINE   6 ( 10 )   1049 - 1060   2004.10( ISSN：1099-498X )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：JOHN WILEY & SONS LTD  

    Background Gene therapy is being studied as the next generation therapy for hemophilia and several clinical trials have been carried out, albeit with limited success. To explore the possibility of utilizing autologous bone marrow transplantation of genetically modified hematopoietic stem cells for hemophilia gene therapy, we investigated the efficacy of genetically engineered CD34(+) cell transplantation to NOD/SCID mice for expression of human factor VIII (hFVIII).
    Methods CD34(+) cells were transduced with a simian immunodeficiency virus agmTYO1 (SIV)-based lentiviral vector carrying the enhanced green fluorescent protein (eGFP) gene (SIVeGFP) or the hFVIII gene (SIVhFVIII). CD34(+) cells transduced with SIV vectors were transplanted to NOD/SCID mice. Engraftment of transduced CD34(+) cells and expression of transgenes were studied.
    Results We could efficiently transduce CD34(+) cells using the SIVeGFP vector in a dose-dependent manner, reaching a maximum (99.6 +/- 0.1%) at MOI of 5 x 10(3) vector genome/cell. After transducing CD34(+) cells with SIVhFVIII, hFVIII was produced (274.3 +/- 20.1 ng) from 106 CD34(+) cells during 24 h in vitro incubation. Transplantation of SIVhFVIII-transduced CD34(+) cells (5-10 x 10(5)) at a multiplicity of infection (MOI) of 50 vector genome/cell into NOD/SCID mice resulted in successful engraftment of CD34(+) cells and production of hFVIII (minimum 1.2 +/- 0.9 ng/mL, maximum 3.6 +/- 0.8 ng/mL) for at least 60 days in vivo. Transcripts of the hFVIII gene and the hFVIII antigen were also detected in the murine bone marrow cells.
    Conclusions Transplantation of ex vivo transduced hematopoietic stem cells by non-pathogenic SIVhFVIII without exposure of subjects to viral vectors is safe and potentially applicable for gene therapy of hemophilia A patients. Copyright (C) 2004 John Wiley Sons, Ltd.

    DOI： 10.1002/jgm.609

    Web of Science

  • Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions. Reviewed

    Takano K,Asazuma N,Satoh K,Yatomi Y,Ozaki Y

    Platelet   15 ( 4 )   223 - 229   2004.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  • Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions. Reviewed Major achievement

    Takano K, Asazuma N, Satoh K, Yatomi Y, Ozaki Y

    Platelet   15 ( 4 )   223 - 229   2004.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Impact Factor: 1.451

  • Thrombophilic Dysfibrinogen Tokyo V with the amino acid substitution of {gamma} Ala-327 to Thr: Formation of fragile but fibrinolysis-resistant fibrin clots and its relevance to arterial thromboembolism. Reviewed

    Hamano A,Mimuro J,Aoshima M,Itoh T,Kitamura N,その他１０名

    Blood   103   3045 - 3050   2004.4

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Thrombophilic dysfibrinogen Tokyo V with the amino acid substitution of gamma Ala327Thr: formation of fragile but fibrinolysis-resistant fibrin clots and its relevance to arterial thromboembolism Reviewed

    A Hamano, J Mimuro, M Aoshima, T Itoh, N Kitamura, S Nishinarita, K Takano, A Ishiwata, Y Kashiwakura, K Niwa, T Ono, S Madoiwa, T Sugo, M Matsuda, Y Sakata

    BLOOD   103 ( 8 )   3045 - 3050   2004.4( ISSN：0006-4971 )

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER SOC HEMATOLOGY  

    Thrombophilic dysfibrinogen Tokyo V was identified in a 43-year-old man with recurrent thromboembolism. Based on analyses of the patient fibrinogen genes, the amino acid sequence of the aberrant fibrinogen peptide, and deglycosylation experiments, fibrinogen Tokyo V was shown to have an amino acid substitution of gamma Ala327Thr and possibly extra glycosylation at gamma Asn325 because the mutation confers the Winked glycosylation consensus sequence Asn-X-Thr. The mutation resulted in impaired function and hypofibrinogenemia (hypodysfibrinogen). Polymerization of fibrin monomers derived from patient fibrinogen was severely impaired with a partial correction in the presence of calcium, resulting in very low clottability. Additionally, a large amount of soluble cross-linked fibrin was formed upon thrombin treatment in the presence of factor XIII and calcium. However, Tokyo V-derived fibrin was resistant to degradation by tissue plasminogen activator (tPA)-catalyzed plasmin digestion. The structure of Tokyo V fibrin appeared severely perturbed, since there are large pores inside the tangled fibrin networks and fiber ends at the boundaries. Taken together, these data suggest that Tokyo V fibrin clots are fragile, so that fibrinolysis-resistant insoluble fibrin and soluble fibrin polymers may be released to the circulation, partly accounting for the recurrent embolic episodes in the patient. (C) 2004 by The American Society of Hematology.

    Web of Science

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Books and Other Publications

  • 血小板形態変化の止血にはたす役割 Major achievement

    高野　勝弘,尾崎　由基男（-）

    中外医学社  2010.1 

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    Total pages：229   Responsible for pages：176-184   Language：Japanese  

  • プロテインC、プロテインS、APCレジスタンス、トロンボモジュリン

    高野勝弘,坂田洋一（-）

    文光堂  2009.2 

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    Total pages：1106   Responsible for pages：662-664   Language：Japanese  

  • プロテインC、プロテインS、APCレジスタンス、トロンボモジュリン Major achievement

    高野 勝弘（-）

    文光堂  2007.2 

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    Total pages：1070   Responsible for pages：637-639-   Language：Japanese  

Presentations

  • 硫酸化多糖カラギナンは、血小板受容体C-type lectin-like receptor2依存的に血小板凝集を惹起する

    横森良平、大石沙織、佐々木知幸、髙野勝弘、井上克枝

    第70回日本臨床検査医学会学術集会  2023.11  一般社団法人日本臨床検査医学会

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    Event date： 2023.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：長崎   Country：Japan  

  • The molecular basis of carrageenan-induced thrombosis involves platelet activation via C-type lectin like receptor 2 (CLEC-2) International conference

    Ryohei Yokomori, Toshiaki Shirai, Saori Oishi, Tomoyuki Sasaki, Nagaharu Tsukiji, Katsuhiro Takano, Katsue Suzuki-Inoue

    ISTH 2023  2023.6  International Society on Thrombosis and Haemostasis

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    Event date： 2023.6

    Language：English   Presentation type：Poster presentation  

    Venue：montreal   Country：Canada  

  • 新型コロナウイルスによる血小板血栓形成メカニズムの解明

    佐々木知幸、白井俊光、築地長治、大石沙織、横森良平、髙野勝弘、森石恆司、井上克枝

    第45回日本血栓止血学会学術集会  2023.6  日本血栓止血学会

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    Event date： 2023.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：北九州市   Country：Japan  

  • 硫酸化多糖カラギナンによるヒト血小板活性化機構

    横森良平、白井俊光、佐々木知幸、築地長治、大石沙織、髙野勝弘、井上克枝

    第45回日本血栓止血学会学術集会  2023.6  一般社団法人　日本血栓止血学会

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    Event date： 2023.6

    Language：Japanese   Presentation type：Poster presentation  

    Venue：北九州市   Country：Japan  

  • 鉄によるCLEC-2依存性血小板活性化機構とその生理的意義

    築地長治、横森良平、田草川一穂、大石沙織、白井俊光、佐々木知幸、髙野勝弘、井上克枝

    第45回日本血栓止血学会学術集会  2023.6  一般社団法人　日本血栓止血学会

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    Event date： 2023.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：北九州市   Country：Japan  

  • Cancer-associated fibroblasts promote venous thrombosis through C-type lectin-like receptor 2/podoplanin in 3LL lung cancer mouse model International conference

    Toshiaki Shirai, Tomoyuki Sasaki, Nagaharu Tsukiji, Saori Ohishi, Ryohei Yokomori, Katsuhiro Takano, Katsue Suzuki-Inoue

    ISTH2022  2022.7  ISTH

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    Event date： 2022.7

    Language：English   Presentation type：Poster presentation  

    Venue：London  

  • Cancer-associated fibroblasts promote venous thrombosis through C-type lectin-like receptor 2/podoplanin in 3LL lung cancer mouse model International conference

    Toshiaki Shirai, Tomoyuki Sasaki, Nagaharu Tsukiji, Saori Ohishi, Ryohei Yokomori, Katsuhiro Takano, Katsue Suzuki-Inoue

    ISTH2022  2022.7  ISTH

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    Language：English   Presentation type：Poster presentation  

    Venue：London  

  • 硫酸化多糖カラギーナンはCLEC-2依存症に血小板を活性化する

    横森良平、白井俊光、佐々木知幸、築地長治、大石沙織、高野勝弘、井上克枝

    第44回日本血栓止血学会学術集会  2022.6  一般社団法人　日本血栓止血学会

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：仙台国際センター　+Web  

  • 癌関連線維芽細胞はCLEC-2/PDPNを介して癌関連血栓症を増悪させる

    白井俊光、佐々木知幸、築地長治、大石沙織、横森良平、高野勝弘、井上克枝

    第44回日本血栓止血学会学術集会  2022.6  一般社団法人　日本血栓止血学会

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：仙台国際センター　+Web  

  • 癌関連線維芽細胞はCLEC-2/PDPNを介して癌関連血栓症を増悪させる

    白井俊光, 佐々木知幸, 築地長治, 大石沙織, 横森良平, 高野勝弘, 井上克枝

    第44回日本血栓止血学会学術集会  2022.6  一般社団法人 日本血栓止血学会

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：仙台国際センター +Web  

  • 硫酸化多糖カラギーナンはCLEC-2依存症に血小板を活性化する

    横森良平, 白井俊光, 佐々木知幸, 築地長治, 大石沙織, 高野勝弘, 井上克枝

    第44回日本血栓止血学会学術集会  2022.6  一般社団法人 日本血栓止血学会

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：仙台国際センター +Web  

  • 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPVIの役割

    大石沙織、築地長治、大竹志門、大石直輝、佐々木知幸、白井俊光、吉河佑莉、髙野勝弘、新森英之、犬飼岳史、近藤哲夫、井上克枝

    第43回日本血栓止血学会学術集会  2021.5  一般社団法人　日本血栓止血学会

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    Event date： 2021.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：オンライン開催  

  • 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPVIの役割

    大石沙織, 築地長治, 大竹志門, 大石直輝, 佐々木知幸, 白井俊光, 吉河佑莉, 髙野勝弘, 新森英之, 犬飼岳史, 近藤哲夫, 井上克枝

    第43回日本血栓止血学会学術集会  2021.5  一般社団法人 日本血栓止血学会

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：オンライン開催  

  • 抗M抗体による新生児溶血性疾患の1例

    笠井慎、渡邊敦、赤羽弘資、合井久美子、中嶋ゆう子、中村美栄、渡邉和亮、原順一、髙野勝弘、井上克枝、犬飼岳史

    第36回山梨輸血研究会  2021.5 

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    Event date： 2021.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨大学医学部臨床講義棟  

  • 照射濃厚血小板輸血後EscherichiaColi による敗血症性ショックを来した1例

    渡辺和亮、中嶋ゆう子、原順一、中村美栄、髙野勝弘、熊谷拓磨、桐戸敬太、井上克枝

    第36回山梨輸血研究会  2021.5 

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    Event date： 2021.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨大学医学部臨床講義棟  

  • 抗M抗体による新生児溶血性疾患の1例

    笠井慎, 渡邊敦, 赤羽弘資, 合井久美子, 中嶋ゆう子, 中村美栄, 渡邉和亮, 原順一, 髙野勝弘, 井上克枝, 犬飼岳史

    第36回山梨輸血研究会  2021.5 

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨大学医学部臨床講義棟  

  • 照射濃厚血小板輸血後EscherichiaColi による敗血症性ショックを来した1例

    渡辺和亮, 中嶋ゆう子, 原順一, 中村美栄, 髙野勝弘, 熊谷拓磨, 桐戸敬太, 井上克枝

    第36回山梨輸血研究会  2021.5 

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨大学医学部臨床講義棟  

  • Heme Activates Platelets and Exacerbates Rhabdomyolysis-Induced Acute Kidney Injury via CLEC-2 and GPVI/FcRγ International conference

    S. Oishi, N. Tsukiji, S. Otake, N. Oishi, T. Sasaki, T. Shirai, Y. Yoshikawa, K. Takano, T. Kondo, K. Suzuki-Inoue

    ISTH 2020 Congress  2020.7  International Society on Thrombosis and Haemostasis

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    Event date： 2020.7

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Virtual  

  • Heme Activates Platelets and Exacerbates Rhabdomyolysis-Induced Acute Kidney Injury via CLEC-2 and GPVI/FcRγ International conference

    S. Oishi, N. Tsukiji, S. Otake, N. Oishi, T. Sasaki, T. Shirai, Y. Yoshikawa, K. Takano, T. Kondo, K. Suzuki-Inoue

    ISTH 2020 Congress  2020.7  International Society on Thrombosis and Haemostasis

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    Language：English   Presentation type：Oral presentation(general)  

    Venue：Virtual  

  • 横紋筋融解症に併発する腎障害における血小板CLEC-2およびGPVIの役割

    大石沙織、築地長治、大竹志門、大石直輝、佐々木知幸、白井俊光、吉河佑莉、髙野勝弘、近藤哲夫、井上克枝

    第42回日本血栓止血学会学術集会  2020.6  一般社団法人　日本血栓止血学会

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    Event date： 2020.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪（web開催）  

  • 巨核球・血小板上C-type lectin-like receptor 2 (CLEC-2)の赤血球造血における役割

    大竹志門、白井俊光、築地長治、佐々木知幸、田村彰吾、髙野勝弘、尾崎由基男、井上克枝

    第42回日本血栓止血学会学術集会  2020.6  一般社団法人　日本血栓止血学会

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    Event date： 2020.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪（web開催）  

  • 巨核球・血小板上C-type lectin-like receptor 2 (CLEC-2)の赤血球造血における役割

    大竹志門, 白井俊光, 築地長治, 佐々木知幸, 田村彰吾, 髙野勝弘, 尾崎由基男, 井上克枝

    第42回日本血栓止血学会学術集会  2020.6  一般社団法人 日本血栓止血学会

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪（web開催）  

  • 横紋筋融解症に併発する腎障害における血小板CLEC-2およびGPVIの役割

    大石沙織, 築地長治, 大竹志門, 大石直輝, 佐々木知幸, 白井俊光, 吉河佑莉, 髙野勝弘, 近藤哲夫, 井上克枝

    第42回日本血栓止血学会学術集会  2020.6  一般社団法人 日本血栓止血学会

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪（web開催）  

  • 山梨県I&A委員会の活動報告〜重大インシデント発生施設の山梨県版I&Aチェックリストによる査察の実施

    高野 勝弘，原 順一，新田 由起子，白倉 久美子，中野 賢一，高野 吉彦，古屋 直樹，宮咲 えり子，後藤 光善，東保 一葉，塚原 達幸

    第68回 日本輸血・細胞治療学会 学術総会  2020.5  日本輸血・細胞治療学会

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    Event date： 2020.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：（札幌コンベンションセンター）コロナのため中止，誌上発表のみ  

  • 山梨県I&A委員会の活動報告〜重大インシデント発生施設の山梨県版I&Aチェックリストによる査察の実施

    高野 勝弘, 原 順一, 新田 由起子, 白倉 久美子, 中野 賢一, 高野 吉彦, 古屋 直樹, 宮咲 えり子, 後藤 光善, 東保 一葉, 塚原 達幸

    第68回 日本輸血・細胞治療学会 学術総会  2020.5  日本輸血・細胞治療学会

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：（札幌コンベンションセンター）コロナのため中止，誌上発表のみ  

  • Platelet C-type Lectin-Like Receptor 2 (CLEC-2) is Required for Optimal Regulation of Erythropoiesis International conference

    S. Otake, T. Shirai, N. Tsukiji, T. Sasaki, K. Satoh, S. Tamura, K. Takano, Y. Ozaki, K. Suzuki-Inoue

    ISTH2019  2019.7  International Society on Thrombosis and Haemostasis (ISTH)

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    Event date： 2019.7

    Language：English   Presentation type：Oral presentation(general)  

    OC 79.2

  • Platelet C-type Lectin-Like Receptor 2 (CLEC-2) is Required for Optimal Regulation of Erythropoiesis International conference

    S. Otake, T. Shirai, N. Tsukiji, T. Sasaki, K. Satoh, S. Tamura, K. Takano, Y. Ozaki, K. Suzuki-Inoue

    ISTH2019  2019.7  International Society on Thrombosis and Haemostasis (ISTH)

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    Language：English   Presentation type：Oral presentation(general)  

    Venue：オーストラリア・メルボルン  

    OC 79.2

  • Heme Induces Platelet Aggregation via Two ITAM Receptors: Implications in Rhabdomyolysis-Induced Acute Kidney Injury International conference

    N. Tsukiji, S. Oishi, S. Otake, T. Sasaki, K. Takano, K. Suzuki-Inoue

    ISTH2019  2019.7  International Society on Thrombosis and Haemostasis (ISTH)

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    Event date： 2019.7

    Language：English   Presentation type：Poster presentation  

    PB0988

  • Heme Induces Platelet Aggregation via Two ITAM Receptors: Implications in Rhabdomyolysis-Induced Acute Kidney Injury International conference

    N. Tsukiji, S. Oishi, S. Otake, T. Sasaki, K. Takano, K. Suzuki-Inoue

    ISTH2019  2019.7  International Society on Thrombosis and Haemostasis (ISTH)

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    Language：English   Presentation type：Poster presentation  

    Venue：オーストラリア・メルボルン  

    PB0988

  • ヘム惹起血小板凝集及び横紋筋融解誘導性急性腎障害における血小板CLEC-2の関与

    築地長治、大竹志門、佐々木知幸、吉河佑莉、高野勝弘、井上克枝

    第41回日本血栓止血学会学術集会  2019.6  一般社団法人　日本血栓止血学会

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    Event date： 2019.6

    Language：Japanese   Presentation type：Poster presentation  

    Venue：三重県津市  

    P-053

  • ヘム惹起血小板凝集及び横紋筋融解誘導性急性腎障害における血小板CLEC-2の関与

    築地長治, 大竹志門, 佐々木知幸, 吉河佑莉, 高野勝弘, 井上克枝

    第41回日本血栓止血学会学術集会  2019.6  一般社団法人 日本血栓止血学会

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：三重県津市  

    P-053

  • 山梨県I&A委員会の活動による県内病院の学会I&A認定取得勧奨（第２報）と輸血医療に係る相互視察の実施

    原順一，金子誠，白倉久美子，高野吉彦，中野賢一，新田由起子，古屋直樹，浅川萌，塚原達幸，宮咲えり子，高野勝弘

    第67回 日本輸血・細胞治療学会 学術総会  2019.5  日本輸血・細胞治療学会

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    Event date： 2019.5

    Language：Japanese   Presentation type：Poster presentation  

    Venue：ホテル日航熊本・他，熊本市  

  • 末梢血幹細胞採取開始時期の判断に有用な検査項目の比較検討：Harvest Indexと末梢血CD34陽性細胞数など

    樋口浩二，高野勝弘，山中浩代，中嶋ゆう子，原順一，渡邉和亮，河西由紀，井上克枝

    第67回 日本輸血・細胞治療学会 学術総会  2019.5  日本輸血・細胞治療学会

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    Event date： 2019.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：ホテル日航熊本・他，熊本市  

  • 山梨県I&A委員会の活動による県内病院の学会I&A認定取得勧奨（第２報）と輸血医療に係る相互視察の実施

    原順一, 金子誠, 白倉久美子, 高野吉彦, 中野賢一, 新田由起子, 古屋直樹, 浅川萌, 塚原達幸, 宮咲えり子, 高野勝弘

    第67回 日本輸血・細胞治療学会 学術総会  2019.5  日本輸血・細胞治療学会

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    Language：Japanese   Presentation type：Poster presentation  

    Venue：ホテル日航熊本・他，熊本市  

  • 末梢血幹細胞採取開始時期の判断に有用な検査項目の比較検討：Harvest Indexと末梢血CD34陽性細胞数など

    樋口浩二, 高野勝弘, 山中浩代, 中嶋ゆう子, 原順一, 渡邉和亮, 河西由紀, 井上克枝

    第67回 日本輸血・細胞治療学会 学術総会  2019.5  日本輸血・細胞治療学会

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：ホテル日航熊本・他，熊本市  

  • 県内で発生した輸血関連重大インシデントに対する山梨県合同輸血療法委員会の対応

    赤井洋美，新田由起子，山本誠一，飯野昌樹，大澤浩，原順一，山中浩代，井上克枝，高野勝弘，伊藤直文，中村弘，杉田莞爾

    第67回 日本輸血・細胞治療学会 学術総会  2019.5  日本輸血・細胞治療学会

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    Event date： 2019.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：ホテル日航熊本・他，熊本市  

  • 県内で発生した輸血関連重大インシデントに対する山梨県合同輸血療法委員会の対応

    赤井洋美, 新田由起子, 山本誠一, 飯野昌樹, 大澤浩, 原順一, 山中浩代, 井上克枝, 高野勝弘, 伊藤直文, 中村弘, 杉田莞爾

    第67回 日本輸血・細胞治療学会 学術総会  2019.5  日本輸血・細胞治療学会

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：ホテル日航熊本・他，熊本市  

  • 末梢血幹細胞採取におけるCD34陽性細胞の代替項目としての造血前駆細胞

    樋口 浩二，遠藤 真澄，高野 勝弘，坂本 美穂子，風間 文智，山中 浩代，井上 克枝

    造血細胞移植学会  2019.3 

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    Event date： 2019.3

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪国際会議場  

  • 末梢血幹細胞採取におけるCD34陽性細胞の代替項目としての造血前駆細胞

    樋口 浩二, 遠藤 真澄, 高野 勝弘, 坂本 美穂子, 風間 文智, 山中 浩代, 井上 克枝

    造血細胞移植学会  2019.3 

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪国際会議場  

  • 脳梗塞の増悪因子であるアクロレインの抗血小板作用

    梅谷徳彦、白井俊光、築地長治、佐々木知幸、田村彰吾、佐藤金夫、大竹志門、高野勝弘、横道洋司、尾崎由基男、井上克枝

    第40回日本血栓止血学会学術集会  2018.6  一般社団法人　日本血栓止血学会

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    Event date： 2018.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：北海道・札幌  

  • 尋常性天疱瘡でステロイド治療中に発症し、リツキシマブにより寛解が得られた後天性血友病A

    高野勝弘、輿石めぐみ、三森　徹、桐戸敬太、井上克枝

    第40回日本血栓止血学会学術集会  2018.6  一般社団法人　日本血栓止血学会

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    Event date： 2018.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：北海道・札幌  

  • 尋常性天疱瘡でステロイド治療中に発症し、リツキシマブにより寛解が得られた後天性血友病A

    高野勝弘, 輿石めぐみ, 三森 徹, 桐戸敬太, 井上克枝

    第40回日本血栓止血学会学術集会  2018.6  一般社団法人 日本血栓止血学会

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：北海道・札幌  

  • 脳梗塞の増悪因子であるアクロレインの抗血小板作用

    梅谷徳彦, 白井俊光, 築地長治, 佐々木知幸, 田村彰吾, 佐藤金夫, 大竹志門, 高野勝弘, 横道洋司, 尾崎由基男, 井上克枝

    第40回日本血栓止血学会学術集会  2018.6  一般社団法人 日本血栓止血学会

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    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：北海道・札幌  

  • A mutation of highly conserved glycine in strand 5B of PAI-1 caused Serpinopathy.

    2017.6 

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    Event date： 2017.6

    Language：Japanese   Presentation type：Oral presentation(general)  

  • 甲状腺髄様癌に広範な大動脈内血栓症を発症し、無事甲状腺全摘術を行いえた一例

    髙野　勝弘、小佐野　雅識、増山　敬祐、井上　克枝

    第39回日本血栓止血学会学術集会  2017.6  一般社団法人　日本血栓止血学会

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    Event date： 2017.6

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：名古屋国際会議場  

  • 可溶性CLEC-2は血小板活性化に伴って生成される:可溶性GPVIとの比較検討 Major achievement

    井上　修,長田　誠,中村　純也,横道　洋司,土肥　智貴,金子　誠,蔵野　信,大澤　満,田村　彰吾,佐藤　金夫,高野　勝弘,宮内　克己,代田　浩之,矢冨　裕,井上　克枝,尾崎　由基男

    第37回日本血栓止血学会学術集会  2015.5 

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    Event date： 2015.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨・甲府  

  • Genetically identified two distinct cases of plasminogen activator inhibitor type 1 deficiency in Japan.

    Urano T, Ikuma K, Kanayama N, Takano K, Ozaki Y, Sano H, Suzuki Y, Matsushita T, Kojima T, Iwaki T

    2014.11 

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    Event date： 2014.11

    Language：English   Presentation type：Oral presentation(general)  

  • Helicobacter pylori産生毒素Vacuolating toxin A の結合たんぱくに関する解析 Major achievement

    佐藤　金夫,平山　壽哉,高野　勝弘,井上　克枝,多田　正人,尾崎　由基男

    第36回日本血栓止血学会学術集会  2014.5 

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    Event date： 2014.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪  

  • ヒトPAI-1欠損症は大量出血をきたす～2症例の解析より Major achievement

    長橋　ことみ,岩城　孝行,高野　勝弘,尾崎　由基男,金山　尚裕,梅村　和夫,浦野　哲盟

    第36回日本血栓止血学会学術集会  2014.5 

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    Event date： 2014.5

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪  

  • VacA, the vacuolating cytotoxin of Helicovactor pylori, binds to multimerin1 associated with platelet membranes Major achievement

    XXIVth International Society of Thrombosis and Haemostasis.  2013.7 

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    Event date： 2013.7

    Language：Japanese   Presentation type：Oral presentation(general)  

  • Case Report: Hyper-eosinophilic syndrome complicated by protein S deficiency and superior sagittal sinus thrombosis.

    Takano K, Mitsumori T, Kirito K, Suzuki-Inoue K, Ozaki Y

    2012.6 

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    Event date： 2012.6

    Language：English   Presentation type：Symposium workshop panel(public)  

  • 化学発光酵素免疫測定装置HISCL-2000iによるTAT、PIC、TM、tPAI・C試薬の基礎的検討 Major achievement

    雨宮　憲彦,風間　文智,小岩井　孝夫,遠藤　武,高野　勝弘,尾崎　由基男

    第12回日本検査血液学会  2011.7 

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    Event date： 2011.7

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：倉敷  

  • AML-cuplikeと思われたAML-M1症例 Major achievement

    雨宮　憲彦,風間　文智,小岩井　孝夫,遠藤　武,高野　勝弘,桐戸　敬太

    第12回日本検査血液学会  2011.7 

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    Event date： 2011.7

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：倉敷  

  • アスピリン非投与重症2型糖尿病患者での血小板アスピリン抵抗性の解析 Major achievement

    高野　勝弘,木村　行男,佐藤　金夫,尾崎　由基男

    日本臨床検査自動化学会第41回大会  2009.10 

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    Event date： 2009.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：横浜市  

  • アスピリン非投与重症２型糖尿病患者での血小板アスピリン抵抗性の解析

    高野　勝弘,木村　行男,佐藤　金夫,尾崎　由基男

    日本臨床検査自動化学会会誌  2009.10  日本臨床検査自動化学会

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    Event date： 2009.10

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：パシフィコ横浜  

  • Evaluation of Aspirin Resistance in Aspirin-free Patients with Severe Type-2 Diabetes Mellitus. International conference

    Takano K, Kimura Y, Sato K, Aida K, Kobayashi T, Ozaki Y

    XXII Congress of The International Society on Thrombosis and Haemostasis  2009.7 

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    Event date： 2009.7

    Language：English   Presentation type：Poster presentation  

  • 重症２型糖尿病患者を用いたアスピリン抵抗性の評価-最大凝集率および COX-1 活性の IC50

    木村　行男,高野　勝弘,佐藤　金夫,尾崎　由基男

    日本検査血液学会雑誌  2009.7  日本検査血液学会

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    Event date： 2009.7

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：山梨大学　甲府キャンパス  

  • 血小板におけるアスピリン抵抗性の新規検査法の開発および糖尿病患者での解析 Major achievement

    高野　勝弘,木村　行男,佐藤　金夫,尾崎　由基男

    日本血栓止血学会誌  2008.11  松尾　理

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    Event date： 2008.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪国際交流センター  

  • 血小板におけるアスピリン抵抗性の新規検査法の開発および糖尿病患者での解析 Major achievement

    高野　勝弘,木村　行男,佐藤　金夫,尾崎　由基男

    第31回日本血栓止血学会学術集会  2008.11 

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    Event date： 2008.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：大阪市  

  • 非ヒト霊長類モデル血友病Ａ遺伝子治療前臨床試験へ向けた標識カニクイザルFVIIIの遺伝子導入

    柏倉　裕志,三室　淳,石渡　彰,新村　真則,高野　勝弘,その他６名

    日本血栓止血学会誌  2006.11  日本血栓止血学会

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    Event date： 2006.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：栃木県総合文化センター，宇都宮市本町１－８  

  • 非ヒト霊長類モデルを用いた血友病Ｂ遺伝子治療の基礎的検討

    石渡　彰,三室　淳,水上　浩明,小野　文子,柏倉　裕志,その他１０名

    日本血栓止血学会誌  2006.11  日本血栓止血学会

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    Event date： 2006.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：栃木県総合文化センター，宇都宮市本町１－８  

  • 血液凝固第VII因子の発現による止血反応を強化した血小板の作成

    高野 勝弘

    第29回 日本血栓止血学会  2006.11 

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    Event date： 2006.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：栃木県  

  • Endothelial Cell Specific Expression of Human Factor IX Gene Driven by the Enhanced PAI-1 Promoter in Mice Using AAV1 Vectors. Major achievement

    高野 勝弘

    第12回 日本遺伝子治療学会  2006.8 

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    Event date： 2006.8

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京都  

  • Liver-Directed Gene Therapy for Haemophilia A with Adeno-Associated Virus (AAV) Vectors Carrying the B Domain-Deleted Factor VIII Gene.

    高野 勝弘

    第12回 日本遺伝子治療学会  2006.8 

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    Event date： 2006.8

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：東京都  

  • SIVベクターとGP Ibaプロモータを用いた血小板特異的な in vivo 遺伝子導入

    大森　司,高野　勝弘,柏倉　裕志,石渡　彰,新村　真則,その他６名

    日本血栓止血学会誌  2005.11  日本血栓止血学会

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    Event date： 2005.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：福岡国際会議場，福岡市博多区石城町２－１  

  • 血友病遺伝子治療を目指したカニクイザル第VIII因子cDNAクローニング

    柏倉　裕志,三室　淳,水上　浩明,飯野　あずみ,石渡　彰,その他７名

    日本血栓止血学会  2005.11  日本血栓止血学会

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    Event date： 2005.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：福岡国際会議場，福岡市博多区石城町２－１  

  • ヒト第IX因子特異的抗体に認識される改変型カニクイザル第IX因子の血友病Ｂ遺伝子治療への応用

    石渡　彰,三室　淳,水上　浩明,高野　勝弘,柏倉　裕志,その他７名

    日本血栓止血学会誌  2005.11  日本血栓止血学会

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    Event date： 2005.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：福岡国際会議場，福岡市博多区石城町２－１  

  • 血友病Ａ遺伝子治療：AAV8ベクターを用いた血友病マウス肝臓への第VIII因子遺伝子導入と発現

    石渡　彰,三室　淳,水上　浩明,高野　勝弘,柏倉　裕志,その他８名

    臨床血液  2005.9  日本血液学会，日本臨床血液学会

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    Event date： 2005.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：パシフィコ横浜，横浜市西区みなとみらい１－１－１  

  • Endothelial Cell Specific Expression of Human Factor IX Gene Driven by the Enhanced PAI-1 Promoter in Mice Using AAV1 Vectors.

    K Takano,J Mimuro,H Mizukami,A Ishiwata,Y Kashiwakura,その他７名

    The 11th Annual Meeting of JSGT, 2005  2005.7  Japan Society of Gene Therapy

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    Event date： 2005.7

    Language：English   Presentation type：Oral presentation(general)  

    Venue：慈恵医大，東京都港区西新橋３－２５－８  

  • 第VIII因子欠乏マウスへのシングルAAV1ベクターをもちいた第VIII因子遺伝子導入と発現

    石渡　彰,三室　淳,水上　浩明,高野　勝弘,柏倉　裕志,その他６名

    臨床血液  2004.9  日本血液学会，日本臨床血液学会

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    Event date： 2004.9

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：京都国際会館，京都市左京区宝ヶ池  

  • Possible involvement of HI-5 in platelet activation and megakaryocyte maturation

    Toshiro TAKAFUTA,Katsuhiro TAKANO,Makoto OSADA,Tsukasa OHMORI,Kaneo SATOH,Naoki ASAZUMA,Yutaka YATOMI,Toshiro NAGASAWA,Yukio OZAKI

    The 1st United Kingdom-Japan Platelet Conference.  2002.2 

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    Event date： 2002.2

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Kyoto  

  • 血小板活性化反応における赤血球由来ADPの役割

    佐藤　金夫,高野　勝弘,金子　誠,矢冨　裕,久保田　文雄,尾崎　由基男

    第24回日本血栓止血学会  2001.11 

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    Event date： 2001.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：京都  

  • 巨核球分化に伴うHic-5の発現変化の検討

    ?蓋　寿朗,高野　勝弘,長田　誠,大森　司,佐藤　金夫,浅妻　直樹,矢冨　裕,尾崎　由基男

    第24回日本血栓止血学会  2001.11 

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    Event date： 2001.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：京都  

  • Collagen, but not SFLL, induces marked platelet microparticle formation and platelet procoagulant activity in whole blood Major achievement

    Katsuhiro TAKANO,Kaneo SATOH　　　　　,Naoki ASAZUMA　　　　,Yutaka YATOMI　　　　,Yukio OZAKI　　　　　

    XVIIIth Congress of The International Society on Thrombosis and Haemostasis  2001.7 

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    Event date： 2001.7

    Language：English   Presentation type：Oral presentation(general)  

    Venue：Paris  

  • 全血における血小板マイクロパーティクルの産生 Major achievement

    高野　勝弘,佐藤　金夫,矢冨　裕,尾崎　由基男

    第23回日本血栓止血学会学術集会  2000.11 

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    Event date： 2000.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：名古屋  

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Teaching Experience (On-campus)

  • チュートリアル　コース4（感染/免疫/アレルギー/血液）

    2023Year  Type of subject：Common education (undergraduate)

    「一般血液および血液形態検査」「血液型と輸血」

  • チュートリアル　コース4（感染/免疫/アレルギー/血液）

    2018Year  Type of subject：Common education (undergraduate)

    「一般血液および血液形態検査」「血液型と輸血」

  • チュートリアル　コース6（血液）

    2018Year  Type of subject：Common education (undergraduate)

    「一般血液および血液形態検査」「血液型と輸血」

Other undergraduate student guidance

  • 2019

    Hospital clinical training - total time：80hours

    guidance or Notices other than the above - total time：100hours

Other educational achievements

  • OSCE　内部評価者

    2022

  • 共通テスト　主任監督者

    2021

  • POST-CC OSCE 評価者

    2018

  • OSCE　内部評価者

    2018

  • 次年度採用 研修医採用試験（マッチング） 面接官

    2017

  • 次年度採用 研修医採用試験（マッチング） 面接官

    2016

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Review of master's and doctoral thesis

  • 2022

    Examiner classification：Second reader

    Master ：1people 

  • 2022

    Examiner classification：Second reader

    Doctoral ：1people  (Overseas student)：1people

  • 2021

    Examiner classification：Second reader

    Doctoral ：1people 

  • 2019

    Examiner classification：Second reader

    Master ：0people 

    Doctoral ：2people 

  • 2018

    Examiner classification：Second reader

    Master ：1people 

    Doctoral ：1people 

  • 2017

    Examiner classification：Second reader

    Master ：1people  (Overseas student)：0people

    Doctoral ：1people  (Overseas student)：0people

    Thesis Dr. ：0people  (Overseas student)：0people

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Performance of external announcement guidance

  • 2018

    Japanese papers guidance - Oral presentation - Number of students：3people  (Guidance time)：5hours

    Japanese papers guidance - Academic papers - Number of students：1people  (Guidance time)：40hours

Social Activities

  • 日本血栓止血学会　第8回 教育セミナー

    Role(s)： Lecturer

    日本血栓止血学会  オンライン（Zoom）  2023.11

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    Type：Seminar, workshop

    初期・後期 研修医を対象とした血栓止血学の教育セミナー

  • 高校生への公開授業「血液型と輸血の話」

    Role(s)： Lecturer,　Demonstrator

    山梨大学  山梨大学医学部キャンパス  2023.7

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    Audience： High school students

    Type：Visiting lecture

  • 日本血栓止血学会　第8回 教育セミナー

    Role(s)： Lecturer

    日本血栓止血学会  オンライン（Zoom）  2022.11

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    Type：Seminar, workshop

    初期・後期 研修医を対象とした血栓止血学の教育セミナー

  • 高校生への公開授業「血液型と輸血の話」

    Role(s)： Lecturer,　Demonstrator

    山梨大学  山梨大学医学部キャンパス  2022.7

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    Audience： High school students

    Type：Visiting lecture

  • 日本血栓止血学会　第8回 教育セミナー

    Role(s)： Lecturer

    日本血栓止血学会  オンライン（Zoom）  2021.11

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    Type：Seminar, workshop

    初期・後期 研修医を対象とした血栓止血学の教育セミナー

  • 検査と健康展

    山梨県臨床衛生検査技師会、日本臨床衛生検査技師会  イオンモール甲府昭和  2021.11

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    Audience： High school students,　General

    Type：Seminar, workshop

  • 高校生への公開授業「血液型と輸血の話」

    Role(s)： Lecturer,　Demonstrator

    山梨大学  山梨大学医学部キャンパス  2021.7

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    Audience： High school students

    Type：Visiting lecture

  • 日本血栓止血学会　第8回 教育セミナー

    Role(s)： Lecturer

    日本血栓止血学会  オンライン（Zoom）  2020.11

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    Type：Seminar, workshop

    初期・後期 研修医を対象とした血栓止血学の教育セミナー

  • 検査と健康展

    山梨県臨床衛生検査技師会、日本臨床衛生検査技師会  イオンモール甲府昭和  2020.11

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    Audience： General

    Type：Science festival

  • 検査と健康展

    山梨県臨床衛生検査技師会、日本臨床衛生検査技師会  イオンモール甲府昭和  2019.11

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    Audience： General

    Type：Science festival

  • 日本血栓止血学会　第7回 教育セミナー

    Role(s)： Lecturer

    日本血栓止血学会  千葉　クロスウェーブ船橋  2019.10

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    Type：Seminar, workshop

    初期・後期 研修医を対象とした血栓止血学の教育セミナー

  • 第37回 日本臨床化学会 甲信越支部総会

    Role(s)： Lecturer

    日本臨床化学会 甲信越支部  山梨　石和温泉 ホテル甲斐路  2019.7

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    Audience： Scientific

    Type：Seminar, workshop

  • 山梨臨床検査フォーラム　第６回

    Role(s)： Lecturer

    山梨県臨床衛生検査技師会  山梨　石和温泉 ホテル甲斐路  2019.1

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    Audience： Scientific

    Type：Seminar, workshop

  • 検査と健康展

    山梨県臨床衛生検査技師会、日本臨床衛生検査技師会  イオンモール甲府昭和  2018.11

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    Audience： General

    Type：Science festival

  • 日本血栓止血学会　第６回 教育セミナー

    Role(s)： Lecturer

    日本血栓止血学会  大阪　クロスウェーブ梅田  2018.10

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    Type：Seminar, workshop

    初期・後期 研修医を対象とした血栓止血学の教育セミナー

  • 検査と健康展

    山梨県臨床衛生検査技師会、日本臨床衛生検査技師会  ラザウオーク  2017.11

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    Audience： General

    Type：Science festival

  • 日本血栓止血学会　第５回 教育セミナー

    Role(s)： Lecturer

    日本血栓止血学会  千葉　クロスウェーブ船橋  2017.10

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    Type：Seminar, workshop

    初期・後期 研修医を対象とした血栓止血学の教育セミナー

  • 山梨臨床検査フォーラム　第４回

    Role(s)： Lecturer

    山梨県臨床衛生検査技師会  山梨　石和温泉 ホテル甲斐路  2017.1

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    Audience： Scientific

    Type：Seminar, workshop

  • 検査と健康展

    山梨県臨床衛生検査技師会、日本臨床衛生検査技師会  イオンモール甲府昭和店  2016.11

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    Audience： General

    Type：Science festival

  • 日本血栓止血学会　第４回 教育セミナー

    Role(s)： Advisor

    日本血栓止血学会  大阪　クロスウェーブ梅田  2016.10

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    Type：Seminar, workshop

    初期・後期 研修医を対象とした血栓止血学の教育セミナー

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Professional Memberships

  • 日本感染症学会

    2017.1

  • 日本化学療法学会

    2016.4

  • 日本輸血・細胞治療学会

    2016.4

  • 日本環境感染学会

    2011.4 - 2017.3

  • 日本臨床検査医学会

    2010.3

  • 日本検査血液学会

    2009.7 - 2013.3

  • The American Society of Hematology

    2009.1 - 2020.12

  • International Society on Thrombosis and Haemostasis

    2007.1 - 2013.3

  • 日本血液学会

  • 日本血栓止血学会

  • 日本内科学会

  • 日本輸血・細胞治療学会

  • 日本血液学会

  • 日本血栓止血学会

  • 日本臨床検査医学会

  • 日本感染症学会

  • 日本内科学会

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