Updated on 2024/03/04

写真a

 
Kawashima Ichiroh
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Clinical Medicine (Blood and Medical Oncology) Assistant Professor
Title
Assistant Professor

Other affiliation

  • Clinical Medicine (Blood and Medical Oncology)

Research History

  • 山梨大学医学部附属病院   血液・腫瘍内科   教育医長

    2019.4

  • 山梨大学医学部附属病院   血液・腫瘍内科   教育医長

    2019.4

  • University of Yamanashi   Assistant Professor

    2017.4

  • 山梨大学医学部附属病院   血液・腫瘍内科   病棟医長

    2017.4

  • University of Yamanashi   血液・腫瘍内科   助教

    2017.4

  • 山梨大学医学部附属病院   血液・腫瘍内科   病棟医長

    2017.4

  • 国立がん研究センター中央病院   造血幹細胞移植科   短期レジデント

    2016.4 - 2017.3

  • 国立がん研究センター中央病院   造血幹細胞移植科   短期レジデント

    2016.4 - 2017.3

  • 国立がん研究センター中央病院   造血幹細胞移植科   短期レジデント

    2016.4 - 2017.3

  • University of Yamanashi   University of Yamanashi (Blood and Medical Oncology Course (Blood and Medical Oncology))   Assistant Professor

    2014.4 - 2016.3

  • University of Yamanashi

    2011.4 - 2015.3

  • University of Yamanashi   大学院医学工学総合教育部 先進医療科学専攻 博士課程   大学院生

    2011.4 - 2015.3

  • University of Yamanashi   University of Yamanashi (Blood and Medical Oncology Course (Blood and Medical Oncology))   Medical Staff

    2011.4 - 2013.3

  • University of Yamanashi (Clinical Education Center)

    2009.4 - 2011.3

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Education

  • University of Yamanashi

    2011.4 - 2015.3

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    Country: Japan

Degree

  • 医学博士 ( 2015.3   山梨大学 )

Research Areas

  • Life Science / Hematology and medical oncology

  • Life Science / Hematology and medical oncology  / Hematology

Research Projects

  • Enhanced ER stress response in MPN cells involved in development of myelofibrosis through secretion of GRP78

    Grant number:18K08319  2018.4 - 2021.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KIRITO Keita

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    Initially, we confirmed activation of ER stress response molecules including ATF4, ATF6 and XBP1s in MPN derived cell lines. Enhanced expression of ATF4 were also found in primary megakaryocytes from MPN patients. GRP78, which regulates ER stress response as downstream effector of ATF4, were also elevated in MPN cells and secreted into culture media. Ruxolitinib, a relatively selective inhibitor for JAK kinase, blocked activation of ATF4 and reduced GRP78 secretion from MPN cells. For further study, we cultured MPN cells with human bone marrow derived fibroblast cell line, HS-5. Co-culture with MPN cells enhanced expression of alpha-smooth muscle actin, one of the important marker for cancer associated fibroblast. Expression of lysyl oxidase, an enzyme which mediates cross-linking of collagen fibers, was also increased. Taken together , enhanced ER stress response in MPN cells might contribute to development of myelofibrosis through GRP78-mediated activation of fibroblast.

  • Role of glucose metabolism in development of myelofibrosis

    Grant number:15K09470  2015.4 - 2018.3

    Japan Society for the Promotion of Science  University of Yamanashi  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KIRITO Keita

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    In the present study, we focused our attention on the role of microenvironment and cell to cell interaction to understand the mechanisms for development of myelofibrosis in myeloproliferative neoplasms (MPN). We found that JAK2V617F-positive cell lines derived from MPN patients showed elevation of several ER stress markers including phosphorylation of eIF2-alpha, nuclear localization of ATF6 and XBP1s and upregulation of glucose response protein 78. We also confirmed elevation of Lysyl-oxidase (LOX), an enzyme that regulates the crosslinking of extracellular matrix proteins such as collagen in these cells. Treatment with metformin diminished activation of ER stress pathways and suppressed LOX levels. These results indicated that LOX levels were regulated by ER stress in MPN cells. In addition, it is suggested that metformin might be a new and attractive compounds to suppress myelofibrosis in MPN.

Papers

  • Molecular and clinicopathological features of granzyme B-negative extranodal NK/T-cell lymphoma Reviewed International coauthorship

    Minh-Khang Le, Naoki Oishi, Akira Satou, Masashi Miyaoka, Ichiro Kawashima, Kunio Mochizuki, Keita Kirito, Andrew L Feldman, Naoya Nakamura, Tetsuo Kondo

    Human Pathology   143   10 - 16   2024.1( ISSN:0046-8177 )

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  • Pre-exposure prophylaxis with tixagevimab/cilgavimab for coronavirus disease 2019 (COVID-19) during the Omicron BA. 5 wave at a single institution in Japan Reviewed

    Ichiro Kawashima, Hideto Hyuga, Ayato Nakadate, Minori Matsuura, Yuma Sakamoto, Jun Suzuki, Takuma Kumagai, Megumi Suzuki, Megumi Koshiishi, Takeo Yamamoto, Kei Nakajima, Masaru Tanaka, Keita Kirito

    International Journal of Hematology   2023.9( ISSN:0925-5710 )

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  • The chaperone protein GRP78 released from MPN cells increases the expression of lysyl oxidase in a human stromal cell line Reviewed

    Kei Nakajima, Megumi Suzuki, Ichiro Kawashima, Megumi Koshiisi, Takuma Kumagai, Takeo Yamamoto, Masaru Tanaka, Keita Kirito

    Leukemia Research   134   2023.9( ISSN:1873-5835 )

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  • Genetic and immunohistochemical profiling of NK/T-cell lymphomas reveals rognostically relevant BCOR-MYC association Reviewed

    Blood Advances   2023.1( ISSN:2473-9529 )

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  • Chronic neutrophilic leukemia/chronic eosinophilic leukemia Invited Reviewed

    Ichiro Kawashima, Keita Kirito

    Rinsho Ketsueki   64 ( 10 )   1326 - 1334   2023.1

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  • Hypokalemia and potassium replacement therapy in allogeneic hematopoietic stem cell transplantation Reviewed

    Ichiro Kawashima, Hideto Hyuga, Ayato Nakadate, Eriko Hosokawa, Yuma Sakamoto, Jun Suzuki, Takuma Kumagai, Megumi Koshiishi, Megumi Suzuki, Takeo Yamamoto, Kei Nakajima, Keita Kirito

    Rinsho ketsueki   64 ( 2 )   83 - 90   2022.11

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  • Presence of bone marrow fibrosis in multiple myeloma may predict extramedullary disease Reviewed

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2022.5( ISSN:0925-5710 )

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  • Presence of bone marrow fibrosis in multiple myeloma may predict extramedullary disease Reviewed

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2022.5( ISSN:0925-5710 )

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  • A phase II randomized study evaluating azacitidine versus conventional care regimens in newly diagnosed elderly Japanese patients with unfavorable acute myeloid leukemia Reviewed

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2022.2( ISSN:0925-5710 )

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  • A phase II randomized study evaluating azacitidine versus conventional care regimens in newly diagnosed elderly Japanese patients with unfavorable acute myeloid leukemia Reviewed

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2022.2( ISSN:0925-5710 )

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  • Prognostic implication of CTLA-4, PD-1, and PD-L1 expression in aggressive adult T-cell leukemia–lymphoma Reviewed

    ANNALS OF HEMATOLOGY   2022.1( ISSN:0939-5555 )

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  • Prognostic implication of CTLA-4, PD-1, and PD-L1 expression in aggressive adult T-cell leukemia–lymphoma Reviewed

    ANNALS OF HEMATOLOGY   2022.1( ISSN:0939-5555 )

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  • Transdifferentiation of mantle cell lymphoma into sarcoma with limited neuromuscular differentiation after conventional chemotherapy Reviewed

    VIRCHOWS ARCHIV   2021.7( ISSN:0945-6317 )

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  • Transdifferentiation of mantle cell lymphoma into sarcoma with limited neuromuscular differentiation after conventional chemotherapy Reviewed

    VIRCHOWS ARCHIV   2021.7( ISSN:0945-6317 )

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  • Early Transformation to Classic Hodgkin Lymphoma in a Chemotherapy-naïve Chronic Lymphocytic Leukemia Patient upon Initial Treatment with Ibrutinib Reviewed

    INTERNAL MEDICINE   2021.3( ISSN:0918-2918 )

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  • Early Transformation to Classic Hodgkin Lymphoma in a Chemotherapy-naïve Chronic Lymphocytic Leukemia Patient upon Initial Treatment with Ibrutinib Reviewed

    INTERNAL MEDICINE   2021.3( ISSN:0918-2918 )

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  • Disappearance of bilateral adrenal tumors: immunodeficiency-associated lymphoproliferative disorder in a patient with rheumatoid arthritis Reviewed

    RHEUMATOLOGY   2021.2( ISSN:1462-0324 )

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  • Disappearance of bilateral adrenal tumors: immunodeficiency-associated lymphoproliferative disorder in a patient with rheumatoid arthritis Reviewed

    RHEUMATOLOGY   2021.2( ISSN:1462-0324 )

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  • Post-transplant lymphoproliferative disorder localized to the colon presented with mild diarrhea after cord blood transplantation Reviewed

        2021.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Post-transplant lymphoproliferative disorder localized to the colon presented with mild diarrhea after cord blood transplantation Reviewed

    2021.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Safety and efficacy of anti-programmed cell death-1 monoclonal antibodies before and after allogeneic hematopoietic cell transplantation for relapsed or refractory Hodgkin lymphoma: a multicenter retrospective study Reviewed

    Ayumu Ito, Sung-Won Kim, Ken-Ichi Matsuoka, Toshiro Kawakita, Takashi Tanaka, Yoshihiro Inamoto, Tomomi Toubai, Shin-Ichiro Fujiwara, Masafumi Fukaya, Tadakazu Kondo, Junichi Sugita, Miho Nara, Yuna Katsuoka, Yosuke Imai, Hideyuki Nakazawa, Ichiro Kawashima, Rika Sakai, Arata Ishii, Makoto Onizuka, Tomonari Takemura, Seitaro Terakura, Hiroatsu Iida, Mika Nakamae, Kohei Higuchi, Shinobu Tamura, Satoshi Yoshioka, Kazuto Togitani, Noriaki Kawano, Ritsuro Suzuki, Junji Suzumiya, Koji Izutsu, Takanori Teshima, Takahiro Fukuda

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2020.8( ISSN:0925-5710 )

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  • Safety and efficacy of anti-programmed cell death-1 monoclonal antibodies before and after allogeneic hematopoietic cell transplantation for relapsed or refractory Hodgkin lymphoma: a multicenter retrospective study Reviewed

    Ayumu Ito, Sung-Won Kim, Ken-Ichi Matsuoka, Toshiro Kawakita, Takashi Tanaka, Yoshihiro Inamoto, Tomomi Toubai, Shin-Ichiro Fujiwara, Masafumi Fukaya, Tadakazu Kondo, Junichi Sugita, Miho Nara, Yuna Katsuoka, Yosuke Imai, Hideyuki Nakazawa, Ichiro Kawashima, Rika Sakai, Arata Ishii, Makoto Onizuka, Tomonari Takemura, Seitaro Terakura, Hiroatsu Iida, Mika Nakamae, Kohei Higuchi, Shinobu Tamura, Satoshi Yoshioka, Kazuto Togitani, Noriaki Kawano, Ritsuro Suzuki, Junji Suzumiya, Koji Izutsu, Takanor

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2020.8( ISSN:0925-5710 )

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  • Detrimental effects of pretransplant cisplatin-based chemotherapy on renal function after allogeneic hematopoietic cell transplantation for lymphoma

    Akio Onishi, Yoshihiro Inamoto, Kinuko Tajima, Junko Yamaguchi, Ichiro Kawashima, Akihisa Kawajiri, Tomonari Takemura, Ayumu Ito, Takashi Tanaka, Keiji Okinaka, Shigeo Fuji, Saiko Kurosawa, Sung-Won Kim, Takahiro Fukuda

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   55 ( 11 )   2196 - 2198   2020.5( ISSN:1083-8791 )

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    DOI: 10.1038/s41409-020-0917-2

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  • 多彩な自己免疫異常と骨髄線維症を併発した血管免疫芽球性T細胞リンパ腫 Reviewed

    松浦 未乃莉, 輿石 めぐみ, 鈴木 潤, 鈴木 愛, 川島 一郎, 中嶌 圭, 桐戸 敬太

    臨床血液   61 ( 2 )   110 - 115   2020.3( ISSN:1882-0824 )

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  • 多彩な自己免疫異常と骨髄線維症を併発した血管免疫芽球性T細胞リンパ腫 Reviewed

    松浦 未乃莉, 輿石 めぐみ, 鈴木 潤, 鈴木 愛, 川島 一郎, 中嶌 圭, 桐戸 敬太

    臨床血液   61 ( 2 )   110 - 115   2020.3( ISSN:1882-0824 )

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  • Glycolytic enzyme hexokinase II is a putative therapeutic target in B-cell malignant lymphoma Reviewed

    Kei Nakajima, Ichiro Kawashima, Megumi Koshiisi, Takuma Kumagai, Megumi Suzuki, Jun Suzuki, Toru Mitsumori, Keita Kirito

    EXPERIMENTAL HEMATOLOGY   78   46 - 55   2019.9( ISSN:0301-472X )

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    DOI: 10.1016

  • Glycolytic enzyme hexokinase II is a putative therapeutic target in B-cell malignant lymphoma Reviewed

    Kei Nakajima, Ichiro Kawashima, Megumi Koshiisi, Takuma Kumagai, Megumi Suzuki, Jun Suzuki, Toru Mitsumori, Keita Kirito

    EXPERIMENTAL HEMATOLOGY   78   46 - 55   2019.9( ISSN:0301-472X )

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  • Molecular response of CSF3R T618I harboring chronic neutrophilic leukemia after induction chemotherapy linked to cord blood transplantation Reviewed

    Ichiro Kawashima, Takuma Kumagai, Megumi Suzuki, Jun Suzuki, Megumi Koshiishi, Kei Nakajima, Keita Kirito

    ANNALS OF HEMATOLOGY   98 ( 9 )   2249 - 2250   2019.7( ISSN:0939-5555 )

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  • Molecular response of CSF3R T618I harboring chronic neutrophilic leukemia after induction chemotherapy linked to cord blood transplantation Reviewed

    Ichiro Kawashima, Takuma Kumagai, Megumi Suzuki, Jun Suzuki, Megumi Koshiishi, Kei Nakajima, Keita Kirito

    ANNALS OF HEMATOLOGY   98 ( 9 )   2249 - 2250   2019.7( ISSN:0939-5555 )

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  • Bone Marrow Invasion of Small Cell Neuroendocrine Carcinoma of the Endometrium: A Diagnostic Pitfall Mimicking a Haematological Malignancy Reviewed

    Ichiro Kawashima, Hiroko Fukasawa, Kazunari Kasai, Takuma Kumagai, Megumi Koshiishi, Kei Nakajima, Tetsuo Kondo, Akihiko Hashi, Shuji Hirata, Keita Kirito

    INTERNAL MEDICINE   58 ( 17 )   2561 - 2568   2019.5( ISSN:0918-2918 )

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  • Bone Marrow Invasion of Small Cell Neuroendocrine Carcinoma of the Endometrium: A Diagnostic Pitfall Mimicking a Haematological Malignancy Reviewed

    Ichiro Kawashima, Hiroko Fukasawa, Kazunari Kasai, Takuma Kumagai, Megumi Koshiishi, Kei Nakajima, Tetsuo Kondo, Akihiko Hashi, Shuji Hirata, Keita Kirito

    INTERNAL MEDICINE   58 ( 17 )   2561 - 2568   2019.5( ISSN:0918-2918 )

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  • Azacitidine as salvage therapy for relapsed acute myeloid leukemia/myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation Reviewed

    Takayuki Ozawa Shigeo Fuji Ichiro Kawashima Yuki Sueki Masao Hagihara Naoko Handa Reiko Ito Tomoko Yamashita Yuji Kikuchi Akira Ohwada Yasuhiro Matsuura Kota Yoshifuji Takashi Tanaka Yoshihiro Inamoto Saiko Kurosawa Sung‐Won Kim Takahiro Fukuda

    1 - 9   2019.4( ISSN:2573-8461 )

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    DOI: 10.1002

  • Azacitidine as salvage therapy for relapsed acute myeloid leukemia/myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation Reviewed

    Takayuki Ozawa, Shigeo Fuji, Ichiro Kawashima, Yuki Sueki, Masao Hagihara, Naoko Handa, Reiko Ito, Tomoko Yamashita, Yuji Kikuchi, Akira Ohwada, Yasuhiro Matsuura, Kota Yoshifuji, Takashi Tanaka, Yoshihiro Inamoto, Saiko Kurosawa, Sung‐Won Kim, Takahiro Fukuda

    Advances in cell and gene therapy   1 - 9   2019.4( ISSN:2573-8461 )

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  • Combined Coagulopathy can Induce both Hemorrhagic and Thrombotic Complications in Multiple Myeloma Reviewed

    Ichiro Kawashima, Katsuhiro Takano, Takuma Kumagai, Megumi Koshiishi, Saori Oishi, Yuki Sueki, Kei Nakajima, Toru Mitsumori, Keita Kirito

    INTERNAL MEDICINE   57 ( 22 )   3303 - 3306   2018.6( ISSN:0918-2918 )

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    DOI: 10.2169

  • Combined Coagulopathy can Induce both Hemorrhagic and Thrombotic Complications in Multiple Myeloma Reviewed

    Ichiro Kawashima, Katsuhiro Takano, Takuma Kumagai, Megumi Koshiishi, Saori Oishi, Yuki Sueki, Kei Nakajima, Toru Mitsumori, Keita Kirito

    INTERNAL MEDICINE   57 ( 22 )   3303 - 3306   2018.6( ISSN:0918-2918 )

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  • Beneficial impact of low-dose rabbit anti-thymocyte globulin in unrelated hematopoietic stem cell transplantation: focusing on difference between stem cell sources Reviewed

    Takafumi Shichijo, Shigeo Fuji, Kinuko Tajima, Hiroyuki Kubo, Kenji Nozaki, Tadahiro Honda, Junko Yamaguchi, Ichiro Kawashima, Akihisa Kawajiri, Tomonari Takemura, Akio Onishi, Ayumu Ito, Takashi Tanaka, Yoshihiro Inamoto, Saiko Kurosawa, Sung-Won Kim, Takahiro Fukuda

    BONE MARROW TRANSPLANTATION   53 ( 3 )   634 - 639   2018.1( ISSN:0268-3369 )

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    DOI: 10.1038

  • Beneficial impact of low-dose rabbit anti-thymocyte globulin in unrelated hematopoietic stem cell transplantation: focusing on difference between stem cell sources Reviewed

    Takafumi Shichijo, Shigeo Fuji, Kinuko Tajima, Hiroyuki Kubo, Kenji Nozaki, Tadahiro Honda, Junko Yamaguchi, Ichiro Kawashima, Akihisa Kawajiri, Tomonari Takemura, Akio Onishi, Ayumu Ito, Takashi Tanaka, Yoshihiro Inamoto, Saiko Kurosawa, Sung-Won Kim, Takahiro Fukuda

    BONE MARROW TRANSPLANTATION   53 ( 3 )   634 - 639   2018.1( ISSN:0268-3369 )

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    DOI: 10.1038/s41409-017-0045-9

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  • Double-Expressor Lymphoma Is Associated with Poor Outcomes after Allogeneic Hematopoietic Cell Transplantation. Reviewed

    Ichiro Kawashima, Yoshihiro Inamoto, Akiko Miyagi Maeshima, Junko Nomoto, Kinuko Tajima, Tadahiro Honda, Takafumi Shichijo, Akihisa Kawajiri, Tomonari Takemura, Akio Onishi, Ayumu Ito, Takashi Tanaka, Shigeo Fuji, Saiko Kurosawa, Sung-Won Kim, Dai Maruyama, Kensei Tobinai, Yukio Kobayashi, Takahiro Fukuda

    Biology of Blood and Marrow Transplantation   S1083   2017.10( ISSN:1083-8791 )

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  • Double-Expressor Lymphoma Is Associated with Poor Outcomes after Allogeneic Hematopoietic Cell Transplantation. Reviewed

    Ichiro Kawashima, Yoshihiro Inamoto, Akiko Miyagi Maeshima, Junko Nomoto, Kinuko Tajima, Tadahiro Honda, Takafumi Shichijo, Akihisa Kawajiri, Tomonari Takemura, Akio Onishi, Ayumu Ito, Takashi Tanaka, Shigeo Fuji, Saiko Kurosawa, Sung-Won Kim, Dai Maruyama, Kensei Tobinai, Yukio Kobayashi, Takahiro Fukuda

    Biology of Blood and Marrow Transplantation   S1083   2017.10( ISSN:1083-8791 )

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  • Tumor Lysis Syndrome after the Administration of Ruxolitinib in a Patient with Post-polycythemia Vera Myelofibrosis

    Megumi Koshiishi, Yuki Sueki, Ichiro Kawashima, Kei Nakajima, Toru Mitsumori, Keita Kirito

    Internal Medicine   56 ( 17 )   2335 - 2338   2017.9( ISSN:0918-2918 )

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  • Tumor Lysis Syndrome after the Administration of Ruxolitinib in a Patient with Post-polycythemia Vera Myelofibrosis

    Megumi Koshiishi, Yuki Sueki, Ichiro Kawashima, Kei Nakajima, Toru Mitsumori, Keita Kirito

    Internal Medicine   56 ( 17 )   2335 - 2338   2017.9( ISSN:0918-2918 )

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Internal Medicine  

    <p>The development of tumor lysis syndrome (TLS) in association with treatment for myeloproliferative neoplasms (MPNs) is relatively rare. We herein present the case of a post-polycythemia vera (PV) myelofibrosis patient with massive splenomegaly who developed laboratory TLS after treatment with ruxolitinib, a potent JAK1/JAK2 inhibitor. She also exhibited a rapid reduction of spleen volume. Our present case suggests the potential risk of TLS development after ruxolitinib treatment, particularly in patients with massive splenomegaly. </p>

    DOI: 10.2169/internalmedicine.8706-16

  • Metformin inhibits JAK2V617F activity in MPN cells by activating AMPK and PP2A complexes containing the B56α subunit. Reviewed

    Ichiro Kawashima, Keita Kirito

    Experimental Hematology   44 ( 12 )   1156 - 1165   2016.8( ISSN:0301-472X )

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  • Metformin inhibits JAK2V617F activity in MPN cells by activating AMPK and PP2A complexes containing the B56α subunit. Reviewed

    Ichiro Kawashima, Keita Kirito

    Experimental Hematology   44 ( 12 )   1156 - 1165   2016.8( ISSN:0301-472X )

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  • Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells. Reviewed Major achievement

    Ichiro Kawashima,Toru Mitsumori,Yumi Nozaki,Takeo Yamamoto,Yuki Sueki,Kei Nakajima,Keita Kirito

    Experimental Hematology   43 ( 7 )   524 - 533   2015.7( ISSN:0301-472X )

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  • Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells. Reviewed

    Ichiro Kawashima, Toru Mitsumori, Yumi Nozaki, Takeo Yamamoto, Yuki Sueki, Kei Nakajima, Keita Kirito

    Experimental Hematology   43 ( 7 )   524 - 533   2015.7( ISSN:0301-472X )

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  • Gastric invasion of multiple myeloma presenting as gastrointestinal bleeding. Reviewed Major achievement

    Kei Nakajima,Yuki Sueki,Megumi Koshiishi,Ichiro Kawashima,Yumi Nozaki,Toru Mitsumori,Keita Kirito

    International Journal of Hematology   101 ( 6 )   525 - 526   2015.6( ISSN:0925-5710 )

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  • Gastric invasion of multiple myeloma presenting as gastrointestinal bleeding. Reviewed

    Kei Nakajima, Yuki Sueki, Megumi Koshiishi, Ichiro Kawashima, Yumi Nozaki, Toru Mitsumori, Keita Kirito

    International Journal of Hematology   101 ( 6 )   525 - 526   2015.6( ISSN:0925-5710 )

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  • Evans症候群で発症し血小板減少にrituximabとromiplostimが有効であった原発性マクログロブリン血症 Reviewed

    臨床血液   56 ( 3 )   317 - 322   2015.4

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  • Evans症候群で発症し血小板減少にrituximabとromiplostimが有効であった原発性マクログロブリン血症 Reviewed

    56 ( 3 )   317 - 322   2015.4

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  • Mogamulizumabによる肺浸潤治療後に,同種造血幹細胞移植を行った成人T細胞性白血病・リンパ腫 Reviewed

    臨床血液   56 ( 2 )   210 - 215   2015.3

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  • Mogamulizumabによる肺浸潤治療後に,同種造血幹細胞移植を行った成人T細胞性白血病・リンパ腫 Reviewed

    56 ( 2 )   210 - 215   2015.3

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  • Cutaneous invasion of leukemia cells during blastic transformation in a post polycythemia vera myelofibrosis patient Reviewed Major achievement

    Yamamoto T,Yumi Nozaki,Hiroshi Mitsui,Yuki Sueki,Ichiro Kawashima,Kei Nakajima,Toru Mitsumori,Shinji Shimada,Keita Kirito

    INTERNATIONAL JOURNAL OF HEMATOLOGY   100 ( 6 )   525 - 526   2014.12( ISSN:0925-5710 )

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  • Cutaneous invasion of leukemia cells during blastic transformation in a post polycythemia vera myelofibrosis patient Reviewed

    Yamamoto T, Yumi Nozaki, Hiroshi Mitsui, Yuki Sueki, Ichiro Kawashima, Kei Nakajima, Toru Mitsumori, Shinji Shimada, Keita Kirito

    INTERNATIONAL JOURNAL OF HEMATOLOGY   100 ( 6 )   525 - 526   2014.12( ISSN:0925-5710 )

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  • Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells. Reviewed Major achievement

    Toru Mitsumori,Yumi Nozaki,Ichiro Kawashima,Takeo Yamamoto,Yuki Shobu,Kei Nakajima,shoji Morishita,Norio Komatsu,Keita Kirito

    Experimental Hematology   42 ( 9 )   783 - 792   2014.9( ISSN:0301-472X )

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  • Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells. Reviewed

    Toru Mitsumori, Yumi Nozaki, Ichiro Kawashima, Takeo Yamamoto, Yuki Shobu, Kei Nakajima, shoji Morishita, Norio Komatsu, Keita Kirito

    Experimental Hematology   42 ( 9 )   783 - 792   2014.9( ISSN:0301-472X )

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  • Anaplastic large cell lymphoma with paraneoplastic neutrophilia: an association between IL-17 elevation and aggressive disease progression Reviewed Major achievement

    Yuki SUEKI,Yumi NOZAKI,Ichiro KAWASHIMA,Takeo YAMAMOTO,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito

    INTERNATIONAL JOURNAL OF HEMATOLOGY   99 ( 6 )   773 - 776   2014.6( ISSN:0925-5710 )

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  • Anaplastic large cell lymphoma with paraneoplastic neutrophilia: an association between IL-17 elevation and aggressive disease progression Reviewed

    Yuki SUEKI, Yumi NOZAKI, Ichiro KAWASHIMA, Takeo YAMAMOTO, Kei NAKAJIMA, Toru MITSUMORI, Keita Kirito

    INTERNATIONAL JOURNAL OF HEMATOLOGY   99 ( 6 )   773 - 776   2014.6( ISSN:0925-5710 )

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  • ベンダムスチン単剤療法中にサイトメガロウイルス抗原血症をきたした難治低悪性度B細胞性リンパ腫の3例 Major achievement

    三森 徹,末木 侑希,川島 一郎,山本 健夫,野﨑 由美,中嶌 圭,桐戸 敬太

    臨床血液   55 ( 2 )   239 - 243   2014.2

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  • ベンダムスチン単剤療法中にサイトメガロウイルス抗原血症をきたした難治低悪性度B細胞性リンパ腫の3例

    三森 徹, 末木 侑希, 川島 一郎, 山本 健夫, 野﨑 由美, 中嶌 圭, 桐戸 敬太

    臨床血液   55 ( 2 )   239 - 243   2014.2( ISSN:0485-1439 )

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    CiNii Books

    Other Link: http://search.jamas.or.jp/link/ui/2014126566

  • ベンダムスチン単剤療法中にサイトメガロウイルス抗原血症をきたした難治低悪性度B細胞性リンパ腫の3例

    三森 徹, 末木 侑希, 川島 一郎, 山本 健夫, 野﨑 由美, 中嶌 圭, 桐戸 敬太

    臨床血液   55 ( 2 )   239 - 243   2014.2( ISSN:0485-1439 )

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    CiNii Books

    Other Link: http://search.jamas.or.jp/link/ui/2014126566

  • ベンダムスチン単剤療法中にサイトメガロウイルス抗原血症をきたした難治低悪性度B細胞性リンパ腫の3例

    三森 徹, 末木 侑希, 川島 一郎, 山本 健夫, 野﨑 由美, 中嶌 圭, 桐戸 敬太

    臨床血液   55 ( 2 )   239 - 243   2014.2( ISSN:0485-1439 )

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    CiNii Books

    Other Link: http://search.jamas.or.jp/link/ui/2014126566

  • Picture in Clinical Hematology(No.66) 骨髄生検がALアミロイドーシスの診断に有用であったBJPλ型多発性骨髄腫 Major achievement

    中嶌 圭,山本 健夫,三森 徹,野﨑 由美,末木 侑希,川島 一郎,桐戸 敬太,一條 昌志,小林 哲郎,大石 直輝,中澤 匡男,加藤 良平

    臨床血液   54 ( 8 )   689 - 689   2013.8

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  • Rituximab activates Syk and AKT in CD20-positive B cell lymphoma cells dependent on cell membrane cholesterol levels. Reviewed Major achievement

    Yumi NOZAKI,Toru MITSUMORI,Takeo YAMAMOTO,Ichiro KAWASHIMA,Yuki SUEKI,Satoshi HAMANAKA,Norio Komatsu,Keita Kirito

    EXPERIMENTAL HEMATOLOGY   41 ( 8 )   687 - 696   2013.8( ISSN:0301-472X )

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  • Rituximab activates Syk and AKT in CD20-positive B cell lymphoma cells dependent on cell membrane cholesterol levels. Reviewed

    Yumi NOZAKI, Toru MITSUMORI, Takeo YAMAMOTO, Ichiro KAWASHIMA, Yuki SUEKI, Satoshi HAMANAKA, Norio Komatsu, Keita Kirito

    EXPERIMENTAL HEMATOLOGY   41 ( 8 )   687 - 696   2013.8( ISSN:0301-472X )

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  • Picture in Clinical Hematology(No.66) 骨髄生検がALアミロイドーシスの診断に有用であったBJPλ型多発性骨髄腫

    中嶌 圭, 山本 健夫, 三森 徹, 野﨑 由美, 末木 侑希, 川島 一郎, 桐戸 敬太, 一條 昌志, 小林 哲郎, 大石 直輝, 中澤 匡男, 加藤 良平

    臨床血液   54 ( 8 )   689 - 689   2013.8( ISSN:0485-1439 )

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    DOI: 10.11406/rinketsu.54.689

    CiNii Books

    Other Link: http://search.jamas.or.jp/link/ui/2014071665

  • Picture in Clinical Hematology(No.66) 骨髄生検がALアミロイドーシスの診断に有用であったBJPλ型多発性骨髄腫

    中嶌 圭, 山本 健夫, 三森 徹, 野﨑 由美, 末木 侑希, 川島 一郎, 桐戸 敬太, 一條 昌志, 小林 哲郎, 大石 直輝, 中澤 匡男, 加藤 良平

    臨床血液   54 ( 8 )   689 - 689   2013.8( ISSN:0485-1439 )

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    DOI: 10.11406/rinketsu.54.689

    CiNii Books

    Other Link: http://search.jamas.or.jp/link/ui/2014071665

  • 化学療法中に生じた非外傷性脾臓破裂を緊急摘脾で救命し得た芽球性形質細胞様樹状細胞腫瘍 Major achievement

    川島 一郎,末木 侑希,山本 健夫,濱中 聡至,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太

    臨床血液   54 ( 6 )   584 - 586   2013.6

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  • 化学療法中に生じた非外傷性脾臓破裂を緊急摘脾で救命し得た芽球性形質細胞様樹状細胞腫瘍

    川島 一郎, 末木 侑希, 山本 健夫, 濱中 聡至, 野﨑 由美, 中嶌 圭, 三森 徹, 桐戸 敬太

    臨床血液   54 ( 6 )   584 - 586   2013.6( ISSN:0485-1439 )

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    Spontaneous rupture of the spleen is a rare but important complication in hematological malignancies. Without splenectomy, the mortality rate of these patients is nearly 100%. We present a blastic plasmacytoid dendritic cell neoplasm case with this complication. Nine days after initiation of chemotherapy, the patient had increased epigastric pain and a drop in hemoglobin. CT scan showed an enlarged spleen surrounded by hemorrhage. Spontaneous rupture of the spleen was diagnosed. Although the patient had severe bone marrow suppression due to chemotherapy, emergency splenectomy was performed and the patient recovered.

    DOI: 10.11406/rinketsu.54.584

    CiNii Books

    Other Link: https://jlc.jst.go.jp/DN/JALC/10021042484?from=CiNii

  • 化学療法中に生じた非外傷性脾臓破裂を緊急摘脾で救命し得た芽球性形質細胞様樹状細胞腫瘍

    川島 一郎, 末木 侑希, 山本 健夫, 濱中 聡至, 野﨑 由美, 中嶌 圭, 三森 徹, 桐戸 敬太

    臨床血液   54 ( 6 )   584 - 586   2013.6( ISSN:0485-1439 )

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Hematology  

    Spontaneous rupture of the spleen is a rare but important complication in hematological malignancies. Without splenectomy, the mortality rate of these patients is nearly 100%. We present a blastic plasmacytoid dendritic cell neoplasm case with this complication. Nine days after initiation of chemotherapy, the patient had increased epigastric pain and a drop in hemoglobin. CT scan showed an enlarged spleen surrounded by hemorrhage. Spontaneous rupture of the spleen was diagnosed. Although the patient had severe bone marrow suppression due to chemotherapy, emergency splenectomy was performed and the patient recovered.

    DOI: 10.11406/rinketsu.54.584

    CiNii Books

    Other Link: https://jlc.jst.go.jp/DN/JALC/10021042484?from=CiNii

  • Picture in Clinical Hematology(No.61) ATRA内服中にSweet病を併発した急性前骨髄球性白血病 Major achievement

    末木 侑希,川島 一郎,三森 徹,山本 健夫,濱中 聡至,野﨑 由美,中嶌 圭,桐戸 敬太,花輪 書絵,島田 眞路,井上 朋大,中澤 匡男

    臨床血液   54 ( 3 )   261 - 261   2013.3

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  • 多発性髄外腫瘤で発症したMLL遺伝子再構成を伴う混合形質性急性白血病 Major achievement

    川島 一郎,菖蒲 侑希,山本 健夫,濱中 聡至,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太

    臨床血液   54 ( 3 )   290 - 294   2013.3

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  • 多発性髄外腫瘤で発症したMLL遺伝子再構成を伴う混合形質性急性白血病

    川島 一郎, 菖蒲 侑希, 山本 健夫, 濱中 聡至, 野﨑 由美, 中嶌 圭, 三森 徹, 桐戸 敬太

    臨床血液   54 ( 3 )   290 - 294   2013.3( ISSN:0485-1439 )

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    Rearrangements of the mixed lineage leukemia MLL gene at chromosome 11q23 are common chromosomal abnormalities in human leukemia. MLL fused with numerous partner genes causes different leukemia phenotypes that depend on the function of partner genes. MLLT3-MLL is generated by translocation t(9;11), which primarily induces acute myeloid leukemia in humans, whereas MLLT3-MLL induces ALL or biphenotypic leukemia in mice. The microenvironment that surrounds leukemia cells plays a central role in this process. We report a patient with mixed phenotype acute leukemia with MLLT3-MLL. This patient, a 44-year-old woman, initially exhibited extramedullary leukemia with multiple tumors and subsequently developed bone marrow disease. The leukemia cells exhibited myeloid (CD13 and MPO) and B cell (CD19 and CD79a) phenotypes. Chromosomal analysis and RT-PCR assay revealed tumor cells with the MLLT3-MLL fusion gene. We treated this patient with a drug regimen for AML (Ara-C plus anthracycline), and complete remission was obtained. This report describes the fourth case of mixed phenotypic leukemia with extramedullary disease. The extramedullary circumstance may underlie the biphenotypic features of these patients.

    DOI: 10.11406/rinketsu.54.290

    CiNii Books

    Other Link: https://jlc.jst.go.jp/DN/JALC/10016670371?from=CiNii

  • Picture in Clinical Hematology(No.61) ATRA内服中にSweet病を併発した急性前骨髄球性白血病

    末木 侑希, 川島 一郎, 三森 徹, 山本 健夫, 濱中 聡至, 野﨑 由美, 中嶌 圭, 桐戸 敬太, 花輪 書絵, 島田 眞路, 井上 朋大, 中澤 匡男

    臨床血液   54 ( 3 )   261 - 261   2013.3

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  • 多発性髄外腫瘤で発症したMLL遺伝子再構成を伴う混合形質性急性白血病

    川島 一郎, 菖蒲 侑希, 山本 健夫, 濱中 聡至, 野﨑 由美, 中嶌 圭, 三森 徹, 桐戸 敬太

    臨床血液   54 ( 3 )   290 - 294   2013.3( ISSN:0485-1439 )

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Hematology  

    Rearrangements of the mixed lineage leukemia MLL gene at chromosome 11q23 are common chromosomal abnormalities in human leukemia. MLL fused with numerous partner genes causes different leukemia phenotypes that depend on the function of partner genes. MLLT3-MLL is generated by translocation t(9;11), which primarily induces acute myeloid leukemia in humans, whereas MLLT3-MLL induces ALL or biphenotypic leukemia in mice. The microenvironment that surrounds leukemia cells plays a central role in this process. We report a patient with mixed phenotype acute leukemia with MLLT3-MLL. This patient, a 44-year-old woman, initially exhibited extramedullary leukemia with multiple tumors and subsequently developed bone marrow disease. The leukemia cells exhibited myeloid (CD13 and MPO) and B cell (CD19 and CD79a) phenotypes. Chromosomal analysis and RT-PCR assay revealed tumor cells with the MLLT3-MLL fusion gene. We treated this patient with a drug regimen for AML (Ara-C plus anthracycline), and complete remission was obtained. This report describes the fourth case of mixed phenotypic leukemia with extramedullary disease. The extramedullary circumstance may underlie the biphenotypic features of these patients.

    DOI: 10.11406/rinketsu.54.290

    CiNii Books

    Other Link: https://jlc.jst.go.jp/DN/JALC/10016670371?from=CiNii

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Books and Other Publications

  • 原発性骨髄線維症に対するJAK阻害薬によるB細胞リンパ腫発症のリスク.

    川島一郎、桐戸敬太( Role: Joint Work)

    2019 

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    Responsible for pages:692-695   Language:Japanese   Book type:Scholarly book

Presentations

  • 分類不能型から移行した慢性骨髄単球性白血病

    第16回日本血液学会関東甲信越地方会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 実臨床におけるDLBCL中枢神経再発リスク因子と予防的髄注の意義についての検討

    第83回 日本血液学会 総会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 実臨床におけるDLBCL中枢神経再発リスク因子と予防的髄注の意義についての検討

    第83回 日本血液学会 総会  2021.9 

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  • 乳糜胸水を合併したびまん性大細胞型B細胞リンパ腫(DLBCL)

    第15回日本血液学会関東甲信越地方会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation(general)  

  • アザシチジン療法中に器質化肺炎を発症した骨髄異形成症候群

    第14回日本血液学会関東甲信越地方会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 節性病変を伴わず、ARDSで発症した移植後リンパ増殖性疾患

    2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Poster presentation  

  • 節性病変を伴わず、ARDSで発症した移植後リンパ増殖性疾患

    2021.3 

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  • 日本における二次性骨髄線維症の予後予測モデルの比較検討

    第81回日本血液学会学術集会  2019.10 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 骨髄増殖性腫瘍における18F-FDG-PET/CT所見

    第81回日本血液学会学術集会  2019.10 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Poster presentation  

  • 日本における二次性骨髄線維症の予後予測モデルの比較検討

    第81回日本血液学会学術集会  2019.10 

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  • 骨髄増殖性腫瘍における18F-FDG-PET/CT所見

    第81回日本血液学会学術集会  2019.10 

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  • Ruxolitinib と化学療法併用により加療を行ったPOST-ET/MF-AML

    第11回日本血液学会関東甲信越地方会  2019.7 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Oral presentation(general)  

  • Cryptic 型 PML-RAR α 転座を伴った急性前骨髄球性白血病

    第11回日本血液学会関東甲信越地方会  2019.7 

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    Language:Japanese   Presentation type:Oral presentation(general)  

  • 小腸イレウスで発症した腸管限局性移植後リンパ増殖性疾患

    第41回日本造血細胞移植学会総会  2019.5 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Poster presentation  

  • 小腸イレウスで発症した腸管限局性移植後リンパ増殖性疾患

    第41回日本造血細胞移植学会総会  2019.5 

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  • 多彩な自己免疫異常と骨髄線維症を併発した血管免疫芽球性T細胞リンパ腫

    日本血液学会第10回関東甲信越地方会  2019.5 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 多彩な自己免疫異常と骨髄線維症を併発した血管免疫芽球性T細胞リンパ腫

    日本血液学会第10回関東甲信越地方会  2019.5 

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  • 多彩な自己免疫異常と骨髄線維症を併発した血管免疫芽球性T細胞リンパ腫

    第10回日本血液学会関東甲信越地方会  2019.3 

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    Event date: 2019.3

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  • 13 因子欠乏によると思われる出血症状をきたした慢性好中球性白血病

    第10回日本血液学会関東甲信越地方会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • Six cases of central nervous system infection with HHV-6 which complained the only malaise of the lower limbs

    2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • Six cases of central nervous system infection with HHV-6 which complained the only malaise of the lower limbs

    第41回日本造血細胞移植学会  2019.3 

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  • タクロリムス投与中に再発した医原性免疫抑制剤関連リンパ増殖性疾患.

    第649回日本内科学会関東地方会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • タクロリムス投与中に再発した医原性免疫抑制剤関連リンパ増殖性疾患.

    第649回日本内科学会関東地方会  2019.3 

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    Language:Japanese   Presentation type:Oral presentation(general)  

  • Metformin Suppresses Expression of Pre-Fibrotic Enzyme Lysyl-Oxidase Levels through Inhibition of UPR in MPN Cells International conference

    61th ASH Annual Meeting and Exposition  2018.12 

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

  • Metformin Suppresses Expression of Pre-Fibrotic Enzyme Lysyl-Oxidase Levels through Inhibition of UPR in MPN Cells International conference

    61th ASH Annual Meeting and Exposition  2018.12 

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    Language:English   Presentation type:Poster presentation  

  • 多発性骨髄腫の予後と線維化の関連性について

    第80回日本血液学会総会  2018.10 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Poster presentation  

  • 多発性骨髄腫の予後と線維化の関連性について

    第80回日本血液学会総会  2018.10 

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    Language:Japanese   Presentation type:Poster presentation  

  • 全身性エリテマトーデスを合併した血管免疫芽球性T細胞リンパ腫

    第9回日本血液学会関東甲信越地方会  2018.7 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 前リンパ球性白血病の臨床的特徴

    第115回日本内科学会総会  2018.4 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Poster presentation  

  • 前リンパ球性白血病の臨床的特徴

    第115回日本内科学会総会  2018.4 

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    Language:Japanese   Presentation type:Poster presentation  

  • PTCYを用いたHLA半合致移植後に発症した非感染性肺障害

    第8回日本血液学会関東甲信越地方会  2018.3 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • The long-term remission in a patient with double-hit lymphoma after allo-HSCT

    2018.2 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Poster presentation  

  • The long-term remission in a patient with double-hit lymphoma after allo-HSCT

    第40回日本造血幹細胞移植学会  2018.2 

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    Language:Japanese   Presentation type:Poster presentation  

  • Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-1 International conference

    59th ASH Annual Meeting and Exposition  2017.12 

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    Event date: 2017.12

    Language:English   Presentation type:Poster presentation  

  • Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-1 International conference

    59th ASH Annual Meeting and Exposition  2017.12 

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    Language:English   Presentation type:Poster presentation  

  • Coexpresson of MYC and BCL2 is associated with poor outcomes after allogeneic HCT for DLBCL

    2017.9 

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    Event date: 2017.9

    Language:English   Presentation type:Oral presentation(general)  

  • Evaluation of the prognostic implication of CTLA-4, PD-1 and PD-L1 expression in ATL

    2017.9 

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    Event date: 2017.9

    Language:English   Presentation type:Oral presentation(general)  

  • Evaluation of the prognostic implication of CTLA-4, PD-1 and PD-L1 expression in ATL

    第79回日本血液学会 総会  2017.9 

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    Language:English   Presentation type:Oral presentation(general)  

  • Coexpresson of MYC and BCL2 is associated with poor outcomes after allogeneic HCT for DLBCL

    第79回日本血液学会 総会  2017.9 

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    Language:English   Presentation type:Oral presentation(general)  

  • Panobinostat reverses hypoxia-induced hexokinase2-dependent cisplatin resistance in lymphoma cells

    2017.9 

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    Event date: 2017.9

    Language:English   Presentation type:Poster presentation  

  • Panobinostat reverses hypoxia-induced hexokinase2-dependent cisplatin resistance in lymphoma cells

    第79回日本血液学会 総会  2017.9 

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    Language:English   Presentation type:Poster presentation  

  • Benefical impact of low-dose ATG in unrelated peripheral blood stem cell transplantation (uPBSCT)

    2017.9 

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    Event date: 2017.9

    Language:English   Presentation type:Oral presentation(general)  

  • Efficiency and safety of treatment with azacitidine for 5 days; single-center experience

    2017.9 

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    Event date: 2017.9

    Language:English   Presentation type:Poster presentation  

  • Efficiency and safety of treatment with azacitidine for 5 days; single-center experience

    第79回日本血液学会 総会  2017.9 

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    Language:English   Presentation type:Poster presentation  

  • Benefical impact of low-dose ATG in unrelated peripheral blood stem cell transplantation (uPBSCT)

    第79回日本血液学会 総会  2017.9 

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    Language:English   Presentation type:Oral presentation(general)  

  • FluBuMelを前処置とした臍帯血移植における有効性・安全性の検討

    第39回日本造血細胞移植学会 総会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:島根県  

  • FluBuMelを前処置とした臍帯血移植における有効性・安全性の検討

    第39回日本造血細胞移植学会 総会  2017.3 

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    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:島根県  

  • 非寛解期急性骨髄性白血病に対する同種造血幹細胞移植の後方視的解析:ATG製剤によるCD7陽性急性骨髄性白血病に対する抗白血病効果の可能性

    第39回日本造血細胞移植学会 総会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:島根県  

  • 残存病変を有するHLおよびaggressive NHLに 対する同種造血幹細胞移植の予後因子解析

    第39回日本造血細胞移植学会 総会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 残存病変を有するHLおよびaggressive NHLに 対する同種造血幹細胞移植の予後因子解析

    第39回日本造血細胞移植学会 総会  2017.3 

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    Language:Japanese   Presentation type:Oral presentation(general)  

  • 非寛解期急性骨髄性白血病に対する同種造血幹細胞移植の後方視的解析:ATG製剤によるCD7陽性急性骨髄性白血病に対する抗白血病効果の可能性

    第39回日本造血細胞移植学会 総会  2017.3 

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:島根県  

  • 悪性リンパ腫に対する白金製剤を含んだ同種移植前化学療法が腎機能および予後に及ぼす影響

    第39回日本造血細胞移植学会 総会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:島根県  

  • 悪性リンパ腫に対する白金製剤を含んだ同種移植前化学療法が腎機能および予後に及ぼす影響

    第39回日本造血細胞移植学会 総会  2017.3 

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:島根県  

  • Influence of Pretransplant Platinum-Based Chemotherapy on Renal Function and Outcomes after Allogeneic Hematopoietic Cell Transplantation for Lymphoma International conference

    2017.2 

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    Event date: 2017.2

    Language:English   Presentation type:Poster presentation  

  • Influence of Pretransplant Platinum-Based Chemotherapy on Renal Function and Outcomes after Allogeneic Hematopoietic Cell Transplantation for Lymphoma International conference

    BMT Tandem Meetings 2017  2017.2 

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    Language:English   Presentation type:Poster presentation  

  • Azacitidine as salvage therapy for relapsed myeloid malignancies after allo-HSCT

    2016.10 

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    Event date: 2016.10

    Language:English   Presentation type:Oral presentation(general)  

  • Secondary myelofibrosis associated with lymphoid malignancy:a single institution

    2016.10 

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    Event date: 2016.10

    Language:English   Presentation type:Poster presentation  

  • Tumor lysis synndrome associated with ruxolitinib in post-polycythemia vera myel

    2016.10 

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    Event date: 2016.10

    Language:English   Presentation type:Poster presentation  

  • Azacitidine as salvage therapy for relapsed myeloid malignancies after allo-HSCT

    第78回 日本血液学会 総会  2016.10 

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    Language:English   Presentation type:Oral presentation(general)  

  • Secondary myelofibrosis associated with lymphoid malignancy:a single institution

    第78回 日本血液学会 総会  2016.10 

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    Language:English   Presentation type:Poster presentation  

  • Tumor lysis synndrome associated with ruxolitinib in post-polycythemia vera myel

    第78回 日本血液学会 総会  2016.10 

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    Language:English   Presentation type:Poster presentation  

  • 尋常性天疱瘡に合併した後天性血友病A

    第5回日本血液学会関東甲信越地方会  2016.7 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 肺炎球菌感染症を契機に診断された多発性骨髄腫の3例

    第4回日本血液学会関東甲信越地方会  2016.3 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • Metformin Inhibits JAK2V617F Activity By Activating AMPK and PP2A Containing B56 Alpha Subunits in MPN Cells International conference

    57th ASH Annual Meeting and Exposition  2015.12 

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    Event date: 2015.12

    Language:English   Presentation type:Poster presentation  

  • Metformin Inhibits JAK2V617F Activity By Activating AMPK and PP2A Containing B56 Alpha Subunits in MPN Cells International conference

    57th ASH Annual Meeting and Exposition  2015.12 

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  • 当院における、びまん性大細胞型B細胞性リンパ腫に対する喫煙の影響(ポスター) Major achievement

    三森 徹,野﨑 由美,川島 一郎,末木 侑希,中嶌 圭,輿石 めぐみ,桐戸 敬太

    第13回日本臨床腫瘍学会学術集会  2015.7 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:北海道  

  • 副腎血管内大細胞型B細胞性リンパ腫1例 Major achievement

    輿石 めぐみ,熊谷 拓磨,大石 沙織,末木 侑希,川島 一郎,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太

    第3回日本血液学会関東甲信越地方会  2015.7 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:茨城県  

  • MPN症例における重複がんの検討:当施設での経験

    第2回日本血液学会関東甲信越地方会  2015.3 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • Vascular complications of japanese MPN patients undergoing surgery: a single institution's experience(ポスター) Major achievement

    Yuki Sueki,Megumi Koshiishi,Ichiro Kawashima,Takeo Yamamoto,Yumi Nozaki,Kei Nakajima,Toru Mitsumori,Keita Kirito

    第76回日本血液学会学術集会  2014.10 

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    Event date: 2014.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:大阪国際会議場  

  • Successful treatment of DLBCL complicated by cardiac involvement(ポスター) Major achievement

    Aya Sugimura,Yuki Sueki,Ichiro Kawashima,Takeo Yamamoto,Yumi Nozaki,Kei Nakajima,Toru Mitsumori,Keita Kirito

    第76回日本血液学会学術集会  2014.10 

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    Event date: 2014.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:大阪国際会議場  

  • Lymphoplasmacytic lymphoma (LPL)に Evans症候群を合併した1例

    第1回日本血液学会 関東甲信越地方会  2014.4 

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    Event date: 2014.4

    Language:Japanese   Presentation type:Oral presentation(general)  

  • Metformin Exerts Anti-Leukemic Effects Via Direct Inhibition Of Oncogenic Kinase Activity In Leukemia Cells Derived From Myeloproliferative Neoplasms International conference

    2013.12 

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    Event date: 2013.12

    Language:English   Presentation type:Poster presentation  

    Venue:America  

  • Metformin Exerts Anti-Leukemic Effects Via Direct Inhibition Of Oncogenic Kinase Activity In Leukemia Cells Derived From Myeloproliferative Neoplasms International conference

    55th ASH Annual Meeting  2013.12 

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    Language:English   Presentation type:Poster presentation  

    Venue:America  

  • Cytogenetic studies of polycythemia vera; the possible role of trisomy 9 in vascular events(ポスター) Major achievement

    Yuki SUEKI,Takeo YAMAMOTO,Ichiro KAWASHIMA,Yumi NOZAKI,Satoshi HAMANAKA,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito

    第75回日本血液学会学術集会  2013.10 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:札幌市  

  • A critical function for SHP2 in JAK positive myeloproliferative neoplasmas(ポスター) Major achievement

    Toru MITSUMORI,Yumi NOZAKI,Yuki SUEKI,Ichiro KAWASHIMA,Takeo YAMAMOTO,Kei NAKAJIMA,Keita Kirito

    第75回日本血液学会学術集会  2013.10 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:札幌市  

  • 当院にて経験した治療関連骨髄性腫瘍の検討(ポスター) Major achievement

    三森 徹,末木 侑希,川島 一郎,山本 健夫,野﨑 由美,中嶌 圭,桐戸 敬太

    第11回日本臨床腫瘍学会学術集会  2013.8 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:仙台市  

  • 著明なNa血症を伴う中枢性塩類喪失症候群(CSWS)で発症したびまん性大細胞型B細胞性リンパ腫 Major achievement

    成澤宏宗,川島 一郎,末木 侑希,山本 健夫,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太

    日本血液学会第170回例会  2013.7 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:日内会館4階会議室  

  • エネルギー・センサーAMPKをターゲットとした白血病治療への新たなアプローチ Major achievement

    川島 一郎,桐戸 敬太

    第2回産学連携白血病診断研修会  2013.4 

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    Event date: 2013.4

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

    Venue:順天堂大学医学部  

  • 血球貧食症候群を伴う不明熱として発症したALK陽性大型B細胞性リンパ腫 Major achievement

    川島 一郎,末木 侑希,山本 健夫,濱中 聡至,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太

    第169回日本血液学会例会  2013.2 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:NTT東日本関東病院  

  • Metformin restores LKB-1/AMPK function via the inhibition of ERK in leukemia cells(ポスター) Major achievement

    Ichiro KAWASHIMA,Yumi NOZAKI,Yuki SUEKI,Takeo YAMAMOTO,Satoshi HAMANAKA,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito

    第74回日本血液学会学術集会  2012.10 

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    Event date: 2012.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:国立京都国際会館  

  • 低酸素環境はMPN細胞のエピジェネティックな遺伝子応答を改変する(ポスター) Major achievement

    中嶌 圭,三宅 邦夫,川島 一郎,野﨑 由美,山本 健夫,濱中 聡至,三森 徹,久保田 健夫,桐戸 敬太

    第74回日本血液学会学術集会  2012.10 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:国立京都国際会館  

  • Two cases of atypical myeloid leukemia with abnormalities chromosome 21(ポスター) Major achievement

    Takeo YAMAMOTO,Ichiro KAWASHIMA,Yuki SUEKI,Satoshi HAMANAKA,Yumi NOZAKI,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito

    第74回日本血液学会学術集会  2012.10 

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    Event date: 2012.10

    Language:English   Presentation type:Oral presentation(general)  

    Venue:国立京都国際会館  

  • 随外腫瘤を多発したMLL遺伝子再構成を伴う混合形質性急性白血病の1例 Major achievement

    川島 一郎,三森 徹,中嶌 圭,野﨑 由美,山本 健夫,濱中 聡至,桐戸 敬太

    第168回日本血液学会例会  2012.7 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:東京慈恵会医科大学  

  • Bendamusutine単剤療法にてサイトメガロウイルスの再活性化を来たした再発・難治低悪性B細胞性リンパ腫の症例 Major achievement

    三森 徹,野﨑 由美,川島 一郎,山本 健夫,濱中 聡至,中嶌 圭,桐戸 敬太

    第10回日本臨床腫瘍学会学術集会  2012.7 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:大阪国際会議場  

  • 性赤血球増加症における血栓症のリスク解析(ポスター) Major achievement

    山本 健夫,三森 徹,川島 一郎,濱中 聡至,野﨑 由美,中嶌 圭,小松 則夫,桐戸 敬太

    第73回日本血液学会学術集  2011.10 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:名古屋国際会議場  

  • 膵癌が疑われた膵臓原発の髄外性形質細胞腫の1例 Major achievement

    沼田 裕樹,小佐野 雅識,川島 一郎,中嶌 圭,野﨑 由美,山本 健夫,三森 徹,小松 則夫,桐戸 敬太

    第573回日本内科学会関東地方会例  2010.7 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation(general)  

    Venue:日本都市センター(東京都)  

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Teaching Experience (On-campus)

  • チュートリアルコース4

    2022Year  Type of subject:Professional education (undergraduate)

  • 巨赤芽球様貧血

    2018Year

  • 巨赤芽球様貧血

    2017Year

  • 溶血性貧血

    2017Year

Other educational achievements

  • OSCE

    2018

Social Activities

  • 山梨日日新聞 メディカルテラス

    2020.4

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    取材協力と一部執筆。

  • 山梨日日新聞 メディカルテラス

    2020.4

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    取材協力と一部執筆。

  • ミダスの河

    2018.7

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    医療面での助言を行った。

  • ミダスの河

    2018.7

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    医療面での助言を行った。

Professional Memberships

  • 日本輸血・細胞治療学会

    2015.4

  • 日本造血幹細胞移植学会

    2015.4

  • 日本感染症学会

    2011.4

  • 日本内科学会

    2011.4

  • 日本血液学会

    2011.4

  • 日本造血幹細胞移植学会

  • 日本輸血・細胞治療学会

  • 日本血液学会

  • 日本感染症学会

  • 日本内科学会

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