Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Clinical Medicine (Blood and Medical Oncology) Associate Professor
Title
Associate Professor
Ichiroh Kawashima
Other affiliation
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Clinical Medicine (Blood and Medical Oncology) Associate Professor
Research History
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University of Yamanashi Associate Professor
2025.1
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山梨大学医学部附属病院 血液・腫瘍内科 教育医長
2019.4
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山梨大学医学部附属病院 血液・腫瘍内科
2017.4
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University of Yamanashi Assistant Professor
2017.4 - 2024.12
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国立がん研究センター中央病院 造血幹細胞移植科 短期レジデント
2016.4 - 2017.3
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University of Yamanashi University of Yamanashi (Blood and Medical Oncology Course (Blood and Medical Oncology)) Assistant Professor
2014.4 - 2016.3
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University of Yamanashi
2011.4 - 2015.3
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University of Yamanashi 大学院医学工学総合教育部 先進医療科学専攻 博士課程 大学院生
2011.4 - 2015.3
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University of Yamanashi University of Yamanashi (Blood and Medical Oncology Course (Blood and Medical Oncology)) Medical Staff
2011.4 - 2013.3
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University of Yamanashi (Clinical Education Center)
2009.4 - 2011.3
Education
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University of Yamanashi
2011.4 - 2015.3
Country： Japan
Degree
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医学博士 ( 2015.3 山梨大学 )
Research Areas
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Life Science / Hematology and medical oncology / Hematology
Research Projects
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GRP78の発現異常は骨髄増殖性腫瘍の血栓性病態を誘導するか？
Grant number：24K11556 2024.4 - 2029.3
日本学術振興会 科学研究費助成事業 基盤研究(C)
桐戸 敬太, 中嶌 圭, 川島 一郎
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Enhanced ER stress response in MPN cells involved in development of myelofibrosis through secretion of GRP78
Grant number：18K08319 2018.4 - 2021.3
Japan Society for the Promotion of Science University of Yamanashi Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
KIRITO Keita
Initially, we confirmed activation of ER stress response molecules including ATF4, ATF6 and XBP1s in MPN derived cell lines. Enhanced expression of ATF4 were also found in primary megakaryocytes from MPN patients. GRP78, which regulates ER stress response as downstream effector of ATF4, were also elevated in MPN cells and secreted into culture media. Ruxolitinib, a relatively selective inhibitor for JAK kinase, blocked activation of ATF4 and reduced GRP78 secretion from MPN cells. For further study, we cultured MPN cells with human bone marrow derived fibroblast cell line, HS-5. Co-culture with MPN cells enhanced expression of alpha-smooth muscle actin, one of the important marker for cancer associated fibroblast. Expression of lysyl oxidase, an enzyme which mediates cross-linking of collagen fibers, was also increased. Taken together , enhanced ER stress response in MPN cells might contribute to development of myelofibrosis through GRP78-mediated activation of fibroblast.
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Role of glucose metabolism in development of myelofibrosis
Grant number：15K09470 2015.4 - 2018.3
Japan Society for the Promotion of Science University of Yamanashi Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
KIRITO Keita
In the present study, we focused our attention on the role of microenvironment and cell to cell interaction to understand the mechanisms for development of myelofibrosis in myeloproliferative neoplasms (MPN). We found that JAK2V617F-positive cell lines derived from MPN patients showed elevation of several ER stress markers including phosphorylation of eIF2-alpha, nuclear localization of ATF6 and XBP1s and upregulation of glucose response protein 78. We also confirmed elevation of Lysyl-oxidase (LOX), an enzyme that regulates the crosslinking of extracellular matrix proteins such as collagen in these cells. Treatment with metformin diminished activation of ER stress pathways and suppressed LOX levels. These results indicated that LOX levels were regulated by ER stress in MPN cells. In addition, it is suggested that metformin might be a new and attractive compounds to suppress myelofibrosis in MPN.
Papers
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Low serum albumin levels and the nongerminal center B-cell subtype according to the Hans algorithm as strong prognostic factors in ≥ 80-year-old patients with large B-cell lymphoma treated with rituximab-containing chemotherapy Reviewed Major achievement
Ichiro Kawashima, Ayato Nakadate, Hideto Hyuga, Minori Matsuura, Yuma Sakamoto, Jun Suzuki, Takuma Kumagai, Megumi Suzuki, Megumi Yamanda-Koshiishi, Takeo Yamamoto, Kei Nakajima, Naoki Oishi, Tetsuo Kondo & Keita Kirito
Annals of Hematology 105 ( 35 ) 2026.1( ISSN：1432-0584 )
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Isolated bone marrow gamma/delta T-cell lymphoma: A difficult case to classify according to the current WHO classification of lymphoid malignancies Reviewed
Hideto Hyuuga a, Naoki Oishi b, Takuma Kumagai a, Minori Matuura a, Ayato Nakadate a, Yuma Sakamoto a, Jun Suzuki a, Megumi Suzuki a, Megumi Koshiisi a, Ichiro Kawashima a, Takeo Yamamoto a, Kei Nakajima a, Masaru Tanaka a, Tetuso Kondo b, Keita Kirito
Leukemia Research Reports 2025.8( ISSN：2213-0489 )
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Magrolimab plus azacitidine vs physician’s choice in untreated TP53-mutated acute myeloid leukemia: the ENHANCE-2 study Reviewed International coauthorship Major achievement
Joshua F Zeidner, David A Sallman, Christian Récher, Naval G Daver, Anskar YH Leung, Devendra K Hiwase, Marion Subklewe, Thomas Pabst, Pau Montesinos, Richard A Larson, Lindsay Wilde, Anoop K Enjeti, Ichiro Kawashima, Cristina Papayannidis, Jenny O'Nions, Lisa Johnson, Mei Dong, Julie Huang, Taravat Bagheri, Gal Hacohen Kleiman, Calvin Lee, Paresh Vyas
BLOOD 2025.2( ISSN：0006-4971 )
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Molecular and clinicopathological features of granzyme B-negative extranodal NK/T-cell lymphoma Reviewed International coauthorship
Minh-Khang Le, Naoki Oishi, Akira Satou, Masashi Miyaoka, Ichiro Kawashima, Kunio Mochizuki, Keita Kirito, Andrew L Feldman, Naoya Nakamura, Tetsuo Kondo
Human Pathology 143 10 - 16 2024.1( ISSN：0046-8177 )
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Pre-exposure prophylaxis with tixagevimab/cilgavimab for coronavirus disease 2019 (COVID-19) during the Omicron BA. 5 wave at a single institution in Japan Reviewed
Ichiro Kawashima, Hideto Hyuga, Ayato Nakadate, Minori Matsuura, Yuma Sakamoto, Jun Suzuki, Takuma Kumagai, Megumi Suzuki, Megumi Koshiishi, Takeo Yamamoto, Kei Nakajima, Masaru Tanaka, Keita Kirito
International Journal of Hematology 2023.9( ISSN：0925-5710 )
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The chaperone protein GRP78 released from MPN cells increases the expression of lysyl oxidase in a human stromal cell line Reviewed
Kei Nakajima, Megumi Suzuki, Ichiro Kawashima, Megumi Koshiisi, Takuma Kumagai, Takeo Yamamoto, Masaru Tanaka, Keita Kirito
Leukemia Research 134 2023.9( ISSN：1873-5835 )
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Genetic and immunohistochemical profiling of NK/T-cell lymphomas reveals rognostically relevant BCOR-MYC association Reviewed
Blood Advances 2023.1( ISSN：2473-9529 )
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Chronic neutrophilic leukemia/chronic eosinophilic leukemia Invited Reviewed
Ichiro Kawashima, Keita Kirito
Rinsho Ketsueki 64 ( 10 ) 1326 - 1334 2023.1
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Hypokalemia and potassium replacement therapy in allogeneic hematopoietic stem cell transplantation Reviewed
Ichiro Kawashima, Hideto Hyuga, Ayato Nakadate, Eriko Hosokawa, Yuma Sakamoto, Jun Suzuki, Takuma Kumagai, Megumi Koshiishi, Megumi Suzuki, Takeo Yamamoto, Kei Nakajima, Keita Kirito
Rinsho ketsueki 64 ( 2 ) 83 - 90 2022.11
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Presence of bone marrow fibrosis in multiple myeloma may predict extramedullary disease Reviewed
INTERNATIONAL JOURNAL OF HEMATOLOGY 2022.5( ISSN：0925-5710 )
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A phase II randomized study evaluating azacitidine versus conventional care regimens in newly diagnosed elderly Japanese patients with unfavorable acute myeloid leukemia Reviewed
INTERNATIONAL JOURNAL OF HEMATOLOGY 2022.2( ISSN：0925-5710 )
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Prognostic implication of CTLA-4, PD-1, and PD-L1 expression in aggressive adult T-cell leukemia–lymphoma Reviewed
ANNALS OF HEMATOLOGY 2022.1( ISSN：0939-5555 )
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Transdifferentiation of mantle cell lymphoma into sarcoma with limited neuromuscular differentiation after conventional chemotherapy Reviewed
VIRCHOWS ARCHIV 2021.7( ISSN：0945-6317 )
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Early Transformation to Classic Hodgkin Lymphoma in a Chemotherapy-naïve Chronic Lymphocytic Leukemia Patient upon Initial Treatment with Ibrutinib Reviewed
INTERNAL MEDICINE 2021.3( ISSN：0918-2918 )
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Disappearance of bilateral adrenal tumors: immunodeficiency-associated lymphoproliferative disorder in a patient with rheumatoid arthritis Reviewed
RHEUMATOLOGY 2021.2( ISSN：1462-0324 )
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Post-transplant lymphoproliferative disorder localized to the colon presented with mild diarrhea after cord blood transplantation Reviewed
2021.1
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Safety and efficacy of anti-programmed cell death-1 monoclonal antibodies before and after allogeneic hematopoietic cell transplantation for relapsed or refractory Hodgkin lymphoma: a multicenter retrospective study Reviewed
Ayumu Ito, Sung-Won Kim, Ken-Ichi Matsuoka, Toshiro Kawakita, Takashi Tanaka, Yoshihiro Inamoto, Tomomi Toubai, Shin-Ichiro Fujiwara, Masafumi Fukaya, Tadakazu Kondo, Junichi Sugita, Miho Nara, Yuna Katsuoka, Yosuke Imai, Hideyuki Nakazawa, Ichiro Kawashima, Rika Sakai, Arata Ishii, Makoto Onizuka, Tomonari Takemura, Seitaro Terakura, Hiroatsu Iida, Mika Nakamae, Kohei Higuchi, Shinobu Tamura, Satoshi Yoshioka, Kazuto Togitani, Noriaki Kawano, Ritsuro Suzuki, Junji Suzumiya, Koji Izutsu, Takanori Teshima, Takahiro Fukuda
INTERNATIONAL JOURNAL OF HEMATOLOGY 2020.8( ISSN：0925-5710 )
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Detrimental effects of pretransplant cisplatin-based chemotherapy on renal function after allogeneic hematopoietic cell transplantation for lymphoma
Akio Onishi, Yoshihiro Inamoto, Kinuko Tajima, Junko Yamaguchi, Ichiro Kawashima, Akihisa Kawajiri, Tomonari Takemura, Ayumu Ito, Takashi Tanaka, Keiji Okinaka, Shigeo Fuji, Saiko Kurosawa, Sung-Won Kim, Takahiro Fukuda
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 55 ( 11 ) 2196 - 2198 2020.5( ISSN：1083-8791 )
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多彩な自己免疫異常と骨髄線維症を併発した血管免疫芽球性T細胞リンパ腫 Reviewed
松浦 未乃莉, 輿石 めぐみ, 鈴木 潤, 鈴木 愛, 川島 一郎, 中嶌 圭, 桐戸 敬太
臨床血液 61 ( 2 ) 110 - 115 2020.3( ISSN：1882-0824 )
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Glycolytic enzyme hexokinase II is a putative therapeutic target in B-cell malignant lymphoma Reviewed
Kei Nakajima, Ichiro Kawashima, Megumi Koshiisi, Takuma Kumagai, Megumi Suzuki, Jun Suzuki, Toru Mitsumori, Keita Kirito
EXPERIMENTAL HEMATOLOGY 78 46 - 55 2019.9( ISSN：0301-472X )
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Molecular response of CSF3R T618I harboring chronic neutrophilic leukemia after induction chemotherapy linked to cord blood transplantation Reviewed
Ichiro Kawashima, Takuma Kumagai, Megumi Suzuki, Jun Suzuki, Megumi Koshiishi, Kei Nakajima, Keita Kirito
ANNALS OF HEMATOLOGY 98 ( 9 ) 2249 - 2250 2019.7( ISSN：0939-5555 )
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Bone Marrow Invasion of Small Cell Neuroendocrine Carcinoma of the Endometrium: A Diagnostic Pitfall Mimicking a Haematological Malignancy Reviewed
Ichiro Kawashima, Hiroko Fukasawa, Kazunari Kasai, Takuma Kumagai, Megumi Koshiishi, Kei Nakajima, Tetsuo Kondo, Akihiko Hashi, Shuji Hirata, Keita Kirito
INTERNAL MEDICINE 58 ( 17 ) 2561 - 2568 2019.5( ISSN：0918-2918 )
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Azacitidine as salvage therapy for relapsed acute myeloid leukemia/myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation Reviewed
Takayuki Ozawa Shigeo Fuji Ichiro Kawashima Yuki Sueki Masao Hagihara Naoko Handa Reiko Ito Tomoko Yamashita Yuji Kikuchi Akira Ohwada Yasuhiro Matsuura Kota Yoshifuji Takashi Tanaka Yoshihiro Inamoto Saiko Kurosawa Sung‐Won Kim Takahiro Fukuda
1 - 9 2019.4( ISSN：2573-8461 )
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Combined Coagulopathy can Induce both Hemorrhagic and Thrombotic Complications in Multiple Myeloma Reviewed
Ichiro Kawashima, Katsuhiro Takano, Takuma Kumagai, Megumi Koshiishi, Saori Oishi, Yuki Sueki, Kei Nakajima, Toru Mitsumori, Keita Kirito
INTERNAL MEDICINE 57 ( 22 ) 3303 - 3306 2018.6( ISSN：0918-2918 )
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Beneficial impact of low-dose rabbit anti-thymocyte globulin in unrelated hematopoietic stem cell transplantation: focusing on difference between stem cell sources Reviewed
Takafumi Shichijo, Shigeo Fuji, Kinuko Tajima, Hiroyuki Kubo, Kenji Nozaki, Tadahiro Honda, Junko Yamaguchi, Ichiro Kawashima, Akihisa Kawajiri, Tomonari Takemura, Akio Onishi, Ayumu Ito, Takashi Tanaka, Yoshihiro Inamoto, Saiko Kurosawa, Sung-Won Kim, Takahiro Fukuda
BONE MARROW TRANSPLANTATION 53 ( 3 ) 634 - 639 2018.1( ISSN：0268-3369 )
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Double-Expressor Lymphoma Is Associated with Poor Outcomes after Allogeneic Hematopoietic Cell Transplantation. Reviewed Major achievement
Ichiro Kawashima, Yoshihiro Inamoto, Akiko Miyagi Maeshima, Junko Nomoto, Kinuko Tajima, Tadahiro Honda, Takafumi Shichijo, Akihisa Kawajiri, Tomonari Takemura, Akio Onishi, Ayumu Ito, Takashi Tanaka, Shigeo Fuji, Saiko Kurosawa, Sung-Won Kim, Dai Maruyama, Kensei Tobinai, Yukio Kobayashi, Takahiro Fukuda
Biology of Blood and Marrow Transplantation S1083 2017.10( ISSN：1083-8791 )
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Tumor Lysis Syndrome after the Administration of Ruxolitinib in a Patient with Post-polycythemia Vera Myelofibrosis
Megumi Koshiishi, Yuki Sueki, Ichiro Kawashima, Kei Nakajima, Toru Mitsumori, Keita Kirito
Internal Medicine 56 ( 17 ) 2335 - 2338 2017.9( ISSN：0918-2918 )
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Metformin inhibits JAK2V617F activity in MPN cells by activating AMPK and PP2A complexes containing the B56α subunit. Reviewed
Ichiro Kawashima, Keita Kirito
Experimental Hematology 44 ( 12 ) 1156 - 1165 2016.8( ISSN：0301-472X )
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Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells. Reviewed Major achievement
Ichiro Kawashima,Toru Mitsumori,Yumi Nozaki,Takeo Yamamoto,Yuki Sueki,Kei Nakajima,Keita Kirito
Experimental Hematology 43 ( 7 ) 524 - 533 2015.7( ISSN：0301-472X )
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Gastric invasion of multiple myeloma presenting as gastrointestinal bleeding. Reviewed
Kei Nakajima, Yuki Sueki, Megumi Koshiishi, Ichiro Kawashima, Yumi Nozaki, Toru Mitsumori, Keita Kirito
International Journal of Hematology 101 ( 6 ) 525 - 526 2015.6( ISSN：0925-5710 )
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Evans症候群で発症し血小板減少にrituximabとromiplostimが有効であった原発性マクログロブリン血症 Reviewed
臨床血液 56 ( 3 ) 317 - 322 2015.4
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Mogamulizumabによる肺浸潤治療後に，同種造血幹細胞移植を行った成人T細胞性白血病・リンパ腫 Reviewed
臨床血液 56 ( 2 ) 210 - 215 2015.3
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Cutaneous invasion of leukemia cells during blastic transformation in a post polycythemia vera myelofibrosis patient Reviewed
Yamamoto T, Yumi Nozaki, Hiroshi Mitsui, Yuki Sueki, Ichiro Kawashima, Kei Nakajima, Toru Mitsumori, Shinji Shimada, Keita Kirito
INTERNATIONAL JOURNAL OF HEMATOLOGY 100 ( 6 ) 525 - 526 2014.12( ISSN：0925-5710 )
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Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells. Reviewed
Toru Mitsumori, Yumi Nozaki, Ichiro Kawashima, Takeo Yamamoto, Yuki Shobu, Kei Nakajima, shoji Morishita, Norio Komatsu, Keita Kirito
Experimental Hematology 42 ( 9 ) 783 - 792 2014.9( ISSN：0301-472X )
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Anaplastic large cell lymphoma with paraneoplastic neutrophilia: an association between IL-17 elevation and aggressive disease progression Reviewed
Yuki SUEKI, Yumi NOZAKI, Ichiro KAWASHIMA, Takeo YAMAMOTO, Kei NAKAJIMA, Toru MITSUMORI, Keita Kirito
INTERNATIONAL JOURNAL OF HEMATOLOGY 99 ( 6 ) 773 - 776 2014.6( ISSN：0925-5710 )
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ベンダムスチン単剤療法中にサイトメガロウイルス抗原血症をきたした難治低悪性度B細胞性リンパ腫の3例
三森 徹, 末木 侑希, 川島 一郎, 山本 健夫, 野﨑 由美, 中嶌 圭, 桐戸 敬太
臨床血液 55 ( 2 ) 239 - 243 2014.2( ISSN：0485-1439 )
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Rituximab activates Syk and AKT in CD20-positive B cell lymphoma cells dependent on cell membrane cholesterol levels. Reviewed
Yumi NOZAKI, Toru MITSUMORI, Takeo YAMAMOTO, Ichiro KAWASHIMA, Yuki SUEKI, Satoshi HAMANAKA, Norio Komatsu, Keita Kirito
EXPERIMENTAL HEMATOLOGY 41 ( 8 ) 687 - 696 2013.8( ISSN：0301-472X )
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Picture in Clinical Hematology(No.66) 骨髄生検がALアミロイドーシスの診断に有用であったBJPλ型多発性骨髄腫
中嶌 圭, 山本 健夫, 三森 徹, 野﨑 由美, 末木 侑希, 川島 一郎, 桐戸 敬太, 一條 昌志, 小林 哲郎, 大石 直輝, 中澤 匡男, 加藤 良平
臨床血液 54 ( 8 ) 689 - 689 2013.8( ISSN：0485-1439 )
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化学療法中に生じた非外傷性脾臓破裂を緊急摘脾で救命し得た芽球性形質細胞様樹状細胞腫瘍
川島 一郎, 末木 侑希, 山本 健夫, 濱中 聡至, 野﨑 由美, 中嶌 圭, 三森 徹, 桐戸 敬太
臨床血液 54 ( 6 ) 584 - 586 2013.6( ISSN：0485-1439 )
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多発性髄外腫瘤で発症したMLL遺伝子再構成を伴う混合形質性急性白血病
川島 一郎, 菖蒲 侑希, 山本 健夫, 濱中 聡至, 野﨑 由美, 中嶌 圭, 三森 徹, 桐戸 敬太
臨床血液 54 ( 3 ) 290 - 294 2013.3( ISSN：0485-1439 )
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Picture in Clinical Hematology(No.61) ATRA内服中にSweet病を併発した急性前骨髄球性白血病
末木 侑希, 川島 一郎, 三森 徹, 山本 健夫, 濱中 聡至, 野﨑 由美, 中嶌 圭, 桐戸 敬太, 花輪 書絵, 島田 眞路, 井上 朋大, 中澤 匡男
臨床血液 54 ( 3 ) 261 - 261 2013.3
Books and Other Publications
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原発性骨髄線維症に対するJAK阻害薬によるB細胞リンパ腫発症のリスク.
川島一郎、桐戸敬太（ Role： Joint Work）
2019
Presentations
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A Phase 2 study of sequential administration of gilteritinib after MEC chemotherapy in Relapsed/Refractory FLT3-mutated Acute Myeloid Leukemia in adults: Japan adult leukemia study group (JALSG) RR-FLT3-AML220 study International conference
Yuichi Ishikawa, Takahiro Yamauchi, Masashi Sawa, Tomomi Toubai, Yuho Najima, Tetsuya Nishida, Ichiro Kawashima, Yuna Katsuoka, Kazutaka Ozeki, Kensuke Usuki, Toru Kiguchi, Takeshi Saito, Satoru Takada, Ko Fujimoto, Shinya Sato, Tomoya Maeda, Hisayuki Yokoyama, Hiroki Uchida, Takumi Lee, Takashi Ishida, Matsuo Yamamoto, Akiko Saito, Emiko Sakaida, Yoshinobu Maeda, Itaru Matsumura, Yasushi Miyazaki, Hitoshi Kiyoi
the 2025 ASH Annual Meeting 2025.12 American society of hematology
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Golseek-1: A Phase 3, double-blind, randomized study of golcadomide (GOLCA), a potential, first-in-class, oral CELMoD™ agent, + R-CHOP vs placebo + R-CHOP in patients with previously untreated, high-risk, large B-cell lymphoma International conference
Theodoros Vassilakopoulos 1 , Javier Munoz 2 , Huiqiang Huang 3 , Ichiro Kawashima 4 , Sung Yong Oh 5 , Wojciech Jurczak 6 , Juan Miguel Bergua Burgues 7 , Ou Bai 8 , Alejandro Berkovits 9 , Keshu Zhou 10 , Marc Hoffmann 11 , Jason Westin 12 , Maria Bouzani 13 , Michal Kwiatek 14 , Tai-Chung Huang 15 , Argyrios Gkasiamis 16 , Arpankumar Patel 17 , Floriane Boucaud 16 , Adrien Petel 16 , Serena Perna 18 , Grzegorz Nowakowski 19
the 2025 ASH Annual Meeting 2025.12 American society of hematology
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Treatment of relapse/refractory diffuse large B-cell lymphoma: single institute experience
Ichiro Kawashima1, Hideto Hyuga1, Minori Matsuura1, Eriko Hosokawa1, Ayato Nakadate1, Yuuma Sakamoto1, Jun Suzuki1, Takuma Kumagai1, Megumi Suzuki1, Yamada-Koshiishi Megumi1, Takeo Yamamoto1, Kei Nakajima1, Naoki Oishi2, Tetsuo Kondo2, Keita Kirito1
2025.10
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ABCL-1176: GOLSEEK-1: A Phase 3, Double-Blind, Randomized Study of Golcadomide+ R-CHOP vs Placebo+ RCHOP in Patients With Previously Untreated, High-Risk, Large B-Cell Lymphoma International conference
Javier Munoz MD 1 , Qingyuan Zhang MD 2 , Huiqiang Huang MD 3 , Ichiro Kawashima MD 4 , Sung Yong Oh MD 5 , Wojciech Jurczak MD, PhD 6 , Juan Bergua MD 7 , Ou Bai MD 8 , Alejandro Berkovits MD 9 , Keshu Zhou MD 10 , Marc Hoffmann MD 11 , Jason R. Westin MD 12 , Maria Bouzani MD 13 , Michał Kwiatek MD, PhD 14 , Tai-Chung Huang MD 15 , Theodoros Vassilakopoulos MD, PhD 16 , Argyrios Gkasiamis MD 17 , Arpankumar Patel MSc 18 , Floriane Boucaud PharmD 17 , Adrien Petel PharmD 17 … Grzegorz S. Nowakowski MD 19
The thirteenth annual meeting of the Society of Hematologic Oncology (SOHO 2025) 2025.9 the Society of Hematologic Oncology
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同種造血幹細胞移植後再発に対してelranatamabを使用した多発性骨髄腫
川島 一郎, 坂本 勇磨, 中楯 礼人, 松浦 未乃莉, 鈴木 潤, 熊谷 拓磨, 鈴木 愛, 山田 めぐみ, 山本 健夫, 中嶌 圭, 田中 勝, 桐戸 敬太
第47回 日本造血・細胞療法学会総会 2025.2 日本造血・免疫細胞療法学会
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Treatments of patients over 80 with diffuse large B-cell lymphoma: single institute experience
2024.10
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同種造血幹細胞移植後10年後に出現した肝中心静脈閉塞症/肝類洞閉塞症候群(SOS/VOD)
松浦 未乃莉１，川島 一郎１ ，藤原 万衣孔2，井上 朋大2 ，日向 英人１ ， 中楯 礼人１ ，坂本 勇磨１ ，鈴木 潤１ ，鈴木 愛１ ，輿石 めぐみ１ ，山本 健夫１ ， 中嶌 圭１ ，田中 勝１ 近藤 哲夫2 ，桐戸 敬太１
第46回 日本造血・細胞療法学会総会 2024.3 日本造血・免疫細胞療法学会
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Tixagevimab-Cilgavimab for prevention of COVID-19: single institutional-analysis
2023.10
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同種造血幹細胞移植における低カリウム血症と高用量のカリウム補充療法の安全性についての検討
川島 一郎, 日向 英人, 中楯 礼人, 細川 恵理子, 坂本 勇磨, 鈴木 潤, 熊谷 拓磨, 輿石 めぐみ, 鈴木 愛,山本 健夫, 中嶌 圭, 桐戸 敬太
第45回日本造血・免疫細胞療法学会 総会 2023.2 日本造血・免疫細胞療法学会
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分類不能型から移行した慢性骨髄単球性白血病
第16回日本血液学会関東甲信越地方会 2022.3
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実臨床におけるDLBCL中枢神経再発リスク因子と予防的髄注の意義についての検討
第83回 日本血液学会 総会 2021.9
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実臨床におけるDLBCL中枢神経再発リスク因子と予防的髄注の意義についての検討
第83回 日本血液学会 総会 2021.9
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乳糜胸水を合併したびまん性大細胞型B細胞リンパ腫（DLBCL）
第15回日本血液学会関東甲信越地方会 2021.7
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アザシチジン療法中に器質化肺炎を発症した骨髄異形成症候群
第14回日本血液学会関東甲信越地方会 2021.3
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節性病変を伴わず、ARDSで発症した移植後リンパ増殖性疾患
2021.3
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節性病変を伴わず、ARDSで発症した移植後リンパ増殖性疾患
2021.3
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日本における二次性骨髄線維症の予後予測モデルの比較検討
第81回日本血液学会学術集会 2019.10
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骨髄増殖性腫瘍における18F-FDG-PET/CT所見
第81回日本血液学会学術集会 2019.10
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日本における二次性骨髄線維症の予後予測モデルの比較検討
第81回日本血液学会学術集会 2019.10
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骨髄増殖性腫瘍における18F-FDG-PET/CT所見
第81回日本血液学会学術集会 2019.10
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Ruxolitinib と化学療法併用により加療を行ったPOST-ET／MF-AML
第11回日本血液学会関東甲信越地方会 2019.7
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Cryptic 型 PML-RAR α 転座を伴った急性前骨髄球性白血病
第11回日本血液学会関東甲信越地方会 2019.7
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小腸イレウスで発症した腸管限局性移植後リンパ増殖性疾患
第41回日本造血細胞移植学会総会 2019.5
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小腸イレウスで発症した腸管限局性移植後リンパ増殖性疾患
第41回日本造血細胞移植学会総会 2019.5
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多彩な自己免疫異常と骨髄線維症を併発した血管免疫芽球性T細胞リンパ腫
日本血液学会第10回関東甲信越地方会 2019.5
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多彩な自己免疫異常と骨髄線維症を併発した血管免疫芽球性T細胞リンパ腫
日本血液学会第10回関東甲信越地方会 2019.5
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多彩な自己免疫異常と骨髄線維症を併発した血管免疫芽球性T細胞リンパ腫
第10回日本血液学会関東甲信越地方会 2019.3
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13 因子欠乏によると思われる出血症状をきたした慢性好中球性白血病
第10回日本血液学会関東甲信越地方会 2019.3
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Six cases of central nervous system infection with HHV-6 which complained the only malaise of the lower limbs
2019.3
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Six cases of central nervous system infection with HHV-6 which complained the only malaise of the lower limbs
第41回日本造血細胞移植学会 2019.3
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タクロリムス投与中に再発した医原性免疫抑制剤関連リンパ増殖性疾患.
第649回日本内科学会関東地方会 2019.3
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タクロリムス投与中に再発した医原性免疫抑制剤関連リンパ増殖性疾患.
第649回日本内科学会関東地方会 2019.3
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Metformin Suppresses Expression of Pre-Fibrotic Enzyme Lysyl-Oxidase Levels through Inhibition of UPR in MPN Cells International conference
61th ASH Annual Meeting and Exposition 2018.12
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Metformin Suppresses Expression of Pre-Fibrotic Enzyme Lysyl-Oxidase Levels through Inhibition of UPR in MPN Cells International conference
61th ASH Annual Meeting and Exposition 2018.12
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多発性骨髄腫の予後と線維化の関連性について
第80回日本血液学会総会 2018.10
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多発性骨髄腫の予後と線維化の関連性について
第80回日本血液学会総会 2018.10
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全身性エリテマトーデスを合併した血管免疫芽球性T細胞リンパ腫
第9回日本血液学会関東甲信越地方会 2018.7
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前リンパ球性白血病の臨床的特徴
第115回日本内科学会総会 2018.4
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前リンパ球性白血病の臨床的特徴
第115回日本内科学会総会 2018.4
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PTCYを用いたHLA半合致移植後に発症した非感染性肺障害
第8回日本血液学会関東甲信越地方会 2018.3
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The long-term remission in a patient with double-hit lymphoma after allo-HSCT
2018.2
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The long-term remission in a patient with double-hit lymphoma after allo-HSCT
第40回日本造血幹細胞移植学会 2018.2
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Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-1 International conference
59th ASH Annual Meeting and Exposition 2017.12
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Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-1 International conference
59th ASH Annual Meeting and Exposition 2017.12
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Coexpresson of MYC and BCL2 is associated with poor outcomes after allogeneic HCT for DLBCL
2017.9
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Evaluation of the prognostic implication of CTLA-4, PD-1 and PD-L1 expression in ATL
2017.9
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Evaluation of the prognostic implication of CTLA-4, PD-1 and PD-L1 expression in ATL
第79回日本血液学会 総会 2017.9
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Coexpresson of MYC and BCL2 is associated with poor outcomes after allogeneic HCT for DLBCL
第79回日本血液学会 総会 2017.9
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Panobinostat reverses hypoxia-induced hexokinase2-dependent cisplatin resistance in lymphoma cells
2017.9
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Panobinostat reverses hypoxia-induced hexokinase2-dependent cisplatin resistance in lymphoma cells
第79回日本血液学会 総会 2017.9
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Benefical impact of low-dose ATG in unrelated peripheral blood stem cell transplantation (uPBSCT)
2017.9
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Efficiency and safety of treatment with azacitidine for 5 days; single-center experience
2017.9
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Efficiency and safety of treatment with azacitidine for 5 days; single-center experience
第79回日本血液学会 総会 2017.9
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Benefical impact of low-dose ATG in unrelated peripheral blood stem cell transplantation (uPBSCT)
第79回日本血液学会 総会 2017.9
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FluBuMelを前処置とした臍帯血移植における有効性・安全性の検討
第39回日本造血細胞移植学会 総会 2017.3
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FluBuMelを前処置とした臍帯血移植における有効性・安全性の検討
第39回日本造血細胞移植学会 総会 2017.3
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非寛解期急性骨髄性白血病に対する同種造血幹細胞移植の後方視的解析：ATG製剤によるCD7陽性急性骨髄性白血病に対する抗白血病効果の可能性
第39回日本造血細胞移植学会 総会 2017.3
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残存病変を有するHLおよびaggressive NHLに 対する同種造血幹細胞移植の予後因子解析
第39回日本造血細胞移植学会 総会 2017.3
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残存病変を有するHLおよびaggressive NHLに 対する同種造血幹細胞移植の予後因子解析
第39回日本造血細胞移植学会 総会 2017.3
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非寛解期急性骨髄性白血病に対する同種造血幹細胞移植の後方視的解析：ATG製剤によるCD7陽性急性骨髄性白血病に対する抗白血病効果の可能性
第39回日本造血細胞移植学会 総会 2017.3
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悪性リンパ腫に対する白金製剤を含んだ同種移植前化学療法が腎機能および予後に及ぼす影響
第39回日本造血細胞移植学会 総会 2017.3
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悪性リンパ腫に対する白金製剤を含んだ同種移植前化学療法が腎機能および予後に及ぼす影響
第39回日本造血細胞移植学会 総会 2017.3
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Influence of Pretransplant Platinum-Based Chemotherapy on Renal Function and Outcomes after Allogeneic Hematopoietic Cell Transplantation for Lymphoma International conference
2017.2
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Influence of Pretransplant Platinum-Based Chemotherapy on Renal Function and Outcomes after Allogeneic Hematopoietic Cell Transplantation for Lymphoma International conference
BMT Tandem Meetings 2017 2017.2
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Azacitidine as salvage therapy for relapsed myeloid malignancies after allo-HSCT
2016.10
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Secondary myelofibrosis associated with lymphoid malignancy:a single institution
2016.10
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Tumor lysis synndrome associated with ruxolitinib in post-polycythemia vera myel
2016.10
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Azacitidine as salvage therapy for relapsed myeloid malignancies after allo-HSCT
第78回 日本血液学会 総会 2016.10
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Secondary myelofibrosis associated with lymphoid malignancy:a single institution
第78回 日本血液学会 総会 2016.10
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Tumor lysis synndrome associated with ruxolitinib in post-polycythemia vera myel
第78回 日本血液学会 総会 2016.10
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尋常性天疱瘡に合併した後天性血友病A
第5回日本血液学会関東甲信越地方会 2016.7
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肺炎球菌感染症を契機に診断された多発性骨髄腫の3例
第4回日本血液学会関東甲信越地方会 2016.3
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Metformin Inhibits JAK2V617F Activity By Activating AMPK and PP2A Containing B56 Alpha Subunits in MPN Cells International conference
57th ASH Annual Meeting and Exposition 2015.12
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Metformin Inhibits JAK2V617F Activity By Activating AMPK and PP2A Containing B56 Alpha Subunits in MPN Cells International conference
57th ASH Annual Meeting and Exposition 2015.12
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当院における、びまん性大細胞型B細胞性リンパ腫に対する喫煙の影響(ポスター) Major achievement
三森 徹,野﨑 由美,川島 一郎,末木 侑希,中嶌 圭,輿石 めぐみ,桐戸 敬太
第13回日本臨床腫瘍学会学術集会 2015.7
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副腎血管内大細胞型B細胞性リンパ腫1例 Major achievement
輿石 めぐみ,熊谷 拓磨,大石 沙織,末木 侑希,川島 一郎,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太
第3回日本血液学会関東甲信越地方会 2015.7
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MPN症例における重複がんの検討：当施設での経験
第2回日本血液学会関東甲信越地方会 2015.3
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Vascular complications of japanese MPN patients undergoing surgery: a single institution's experience(ポスター) Major achievement
Yuki Sueki,Megumi Koshiishi,Ichiro Kawashima,Takeo Yamamoto,Yumi Nozaki,Kei Nakajima,Toru Mitsumori,Keita Kirito
第76回日本血液学会学術集会 2014.10
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Successful treatment of DLBCL complicated by cardiac involvement(ポスター) Major achievement
Aya Sugimura,Yuki Sueki,Ichiro Kawashima,Takeo Yamamoto,Yumi Nozaki,Kei Nakajima,Toru Mitsumori,Keita Kirito
第76回日本血液学会学術集会 2014.10
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Lymphoplasmacytic lymphoma (LPL）に Evans症候群を合併した1例
第1回日本血液学会 関東甲信越地方会 2014.4
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Metformin Exerts Anti-Leukemic Effects Via Direct Inhibition Of Oncogenic Kinase Activity In Leukemia Cells Derived From Myeloproliferative Neoplasms International conference
2013.12
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Metformin Exerts Anti-Leukemic Effects Via Direct Inhibition Of Oncogenic Kinase Activity In Leukemia Cells Derived From Myeloproliferative Neoplasms International conference
55th ASH Annual Meeting 2013.12
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Cytogenetic studies of polycythemia vera; the possible role of trisomy 9 in vascular events(ポスター) Major achievement
Yuki SUEKI,Takeo YAMAMOTO,Ichiro KAWASHIMA,Yumi NOZAKI,Satoshi HAMANAKA,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito
第75回日本血液学会学術集会 2013.10
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A critical function for SHP2 in JAK positive myeloproliferative neoplasmas(ポスター) Major achievement
Toru MITSUMORI,Yumi NOZAKI,Yuki SUEKI,Ichiro KAWASHIMA,Takeo YAMAMOTO,Kei NAKAJIMA,Keita Kirito
第75回日本血液学会学術集会 2013.10
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当院にて経験した治療関連骨髄性腫瘍の検討(ポスター) Major achievement
三森 徹,末木 侑希,川島 一郎,山本 健夫,野﨑 由美,中嶌 圭,桐戸 敬太
第11回日本臨床腫瘍学会学術集会 2013.8
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著明なNa血症を伴う中枢性塩類喪失症候群(CSWS)で発症したびまん性大細胞型B細胞性リンパ腫 Major achievement
成澤宏宗,川島 一郎,末木 侑希,山本 健夫,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太
日本血液学会第170回例会 2013.7
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エネルギー・センサーAMPKをターゲットとした白血病治療への新たなアプローチ Major achievement
川島 一郎,桐戸 敬太
第2回産学連携白血病診断研修会 2013.4
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血球貧食症候群を伴う不明熱として発症したALK陽性大型B細胞性リンパ腫 Major achievement
川島 一郎,末木 侑希,山本 健夫,濱中 聡至,野﨑 由美,中嶌 圭,三森 徹,桐戸 敬太
第169回日本血液学会例会 2013.2
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Two cases of atypical myeloid leukemia with abnormalities chromosome 21(ポスター) Major achievement
Takeo YAMAMOTO,Ichiro KAWASHIMA,Yuki SUEKI,Satoshi HAMANAKA,Yumi NOZAKI,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito
第74回日本血液学会学術集会 2012.10
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Metformin restores LKB-1/AMPK function via the inhibition of ERK in leukemia cells(ポスター) Major achievement
Ichiro KAWASHIMA,Yumi NOZAKI,Yuki SUEKI,Takeo YAMAMOTO,Satoshi HAMANAKA,Kei NAKAJIMA,Toru MITSUMORI,Keita Kirito
第74回日本血液学会学術集会 2012.10
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低酸素環境はMPN細胞のエピジェネティックな遺伝子応答を改変する(ポスター) Major achievement
中嶌 圭,三宅 邦夫,川島 一郎,野﨑 由美,山本 健夫,濱中 聡至,三森 徹,久保田 健夫,桐戸 敬太
第74回日本血液学会学術集会 2012.10
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随外腫瘤を多発したMLL遺伝子再構成を伴う混合形質性急性白血病の1例 Major achievement
川島 一郎,三森 徹,中嶌 圭,野﨑 由美,山本 健夫,濱中 聡至,桐戸 敬太
第168回日本血液学会例会 2012.7
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Bendamusutine単剤療法にてサイトメガロウイルスの再活性化を来たした再発・難治低悪性B細胞性リンパ腫の症例 Major achievement
三森 徹,野﨑 由美,川島 一郎,山本 健夫,濱中 聡至,中嶌 圭,桐戸 敬太
第10回日本臨床腫瘍学会学術集会 2012.7
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性赤血球増加症における血栓症のリスク解析(ポスター) Major achievement
山本 健夫,三森 徹,川島 一郎,濱中 聡至,野﨑 由美,中嶌 圭,小松 則夫,桐戸 敬太
第73回日本血液学会学術集 2011.10
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膵癌が疑われた膵臓原発の髄外性形質細胞腫の1例 Major achievement
沼田 裕樹,小佐野 雅識,川島 一郎,中嶌 圭,野﨑 由美,山本 健夫,三森 徹,小松 則夫,桐戸 敬太
第573回日本内科学会関東地方会例 2010.7
Teaching Experience (On-campus)
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悪性リンパ腫
2025Year Type of subject：Common education (undergraduate) Country：Japan
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チュートリアルコース４
2022Year Type of subject：Professional education (undergraduate)
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巨赤芽球様貧血
2018Year
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巨赤芽球様貧血
2017Year
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溶血性貧血
2017Year
Other educational achievements
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大学入試共通試験試験監督
2025
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Post-CC-OSCE試験監督
2025
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OSCE
2018
Social Activities
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つばさセミナー「血小板の病気を知ろう」
Role(s)： Appearance
NPO法人血液情報広場・つばさ 2024.6
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山梨日日新聞 メディカルテラス
2020.4
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山梨日日新聞 メディカルテラス
2020.4
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ミダスの河
2018.7
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ミダスの河
2018.7
Professional Memberships
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日本輸血・細胞治療学会
2015.4
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日本造血・免疫細胞療法学会
2015.4
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日本感染症学会
2011.4
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日本内科学会
2011.4
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日本血液学会
2011.4