Updated on 2024/05/01

写真a

 
Uchimura Kohei
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Clinical Medicine (Nephrology) Senior Assistant Professor
Title
Senior Assistant Professor

Other affiliation

  • Graduate Faculty of Interdisciplinary Research Faculty of Medicine

Research History

  • 山梨大学医学部附属病院   腎臓内科   講師

    2022.7

  • 山梨大学医学部付属病院   腎臓内科   講師

    2022.4

  • 山梨大学医学部付属病院   腎臓内科   助教

    2020.4

  • 山梨大学医学部付属病院   血液浄化療法部   副部長

    2020.4

  • 山梨大学医学部付属病院   血液浄化療法部   副部長

    2020.4

  • 山梨大学医学部付属病院   腎臓内科   助教

    2020.4

  • Washington University in St. Louis   Renal Division   Research Associate

    2015.7 - 2020.3

  • Washington University in St. Louis   Renal Division   Research Associate

    2015.7 - 2020.3

  • 山梨大学医学部付属病院   第3内科   助教

    2014.11

  • 山梨大学医学部付属病院   第3内科   助教

    2014.11

  • 熊本大学医学部付属病院   腎臓内科   医員

    2012.4 - 2014.10

  • 熊本大学医学部付属病院   腎臓内科   医員

    2012.4 - 2014.10

  • 熊本大学生命科学研究部   大学院生(医学博士課程)

    2008.4 - 2012.3

  • 熊本大学生命科学研究部   大学院生(医学博士課程)

    2008.4 - 2012.3

  • 八代総合病院   腎センター   医員

    2007.4 - 2008.3

  • 八代総合病院   腎センター   医員

    2007.4 - 2008.3

  • 熊本大学医学部付属病院   腎臓内科   医員

    2006.4 - 2007.3

  • 熊本大学医学部付属病院   腎臓内科   医員

    2006.4 - 2007.3

  • 天草中央総合病院   研修医

    2005.4 - 2006.3

  • 天草中央総合病院   研修医

    2005.4 - 2006.3

  • 熊本大学医学部付属病院   研修医

    2004.4 - 2005.3

  • 熊本大学医学部付属病院   研修医

    2004.4 - 2005.3

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Education

  • 熊本大学生命科学研究部

    2008.4 - 2012.3

  • 熊本大学生命科学研究部

    2008.4 - 2012.3

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    Country: Japan

    Course: Doctor course

  • 熊本大学医学部医学科

    1998.4 - 2004.3

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    Country: Japan

  • 熊本大学医学部医学科

    1998.4 - 2004.3

Degree

  • 医学博士 ( 熊本大学 )

Research Areas

  • Life Science / Nephrology

  • Life Science / Nephrology  / Nephrology

Research Interests

  • Chronic Kidney DiseaseAcute Kidney InjuryHypertensionDiabetesThyroidSerin Protease

Subject of research

  • Nephrology
    Internal medicine of Endocrinology & Metabolism
    Serin protease

Research Projects

  • バーコード標識iPS細胞を用いた腎臓オルガノイド分化・成熟過程における細胞

    2021

    武田科学振興財団  2021年度医学系研究助成(基礎)

  • バーコード標識iPS細胞を用いた腎臓オルガノイド分化・成熟過程における細胞

    2021

    武田科学振興財団  2021年度医学系研究助成(基礎)

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    Grant type:Competitive 

  • 新規腎臓オルガノイドを用いた細胞アッセイへの応用

    2020.4 - 2025.3

    日本学術振興会  基盤研究(C) 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • 新規腎臓オルガノイドを用いた細胞アッセイへの応用

    2020.4 - 2025.3

    日本学術振興会  基盤研究(C) 

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    Grant type:Competitive 

  • 新規腎臓オルガノイドを用いた細胞アッセイへの応用

    2020.4 - 2022.3

    i PS アカデミアジャパン研究助成  201 9 年度 i PS アカデミアジャパン 研究助成 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • 新規腎臓オルガノイドを用いた細胞アッセイへの応用

    2020.4 - 2022.3

    i PS アカデミアジャパン研究助成  201 9 年度 i PS アカデミアジャパン 研究助成 

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    Grant type:Competitive 

  • ヒトiPS 細胞由来腎臓オルガノイドの病態モデルへの応用

    2020.4 - 2021.3

    テルモ生命科学振興財団  再生医療研究

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    Authorship:Principal investigator  Type of fund::Science research expense

  • ヒトiPS細胞由来腎臓オルガノイドを用いたIgA腎症の非観血的診断法の開発

    2020.4 - 2021.3

    近藤記念医学財団  2020年度 学術奨励賞 

  • ヒトiPS由来腎臓オルガノイドを用いた高尿酸腎障害モデルの確立

    2020.4 - 2021.3

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    Authorship:Principal investigator  Type of fund::Science research expense

  • プロスタシンを軸とした肝臓インスリン感受性および膵臓インスリン分泌の調節機構

    2020.4 - 2021.3

    日本応用酵素協会Front Runner of Future Diabetes Research 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • 新規腎臓オルガノイドを用いた病態モデルへの応用

    2020.4 - 2021.3

    持田記念医学薬学振興財団  2020 年度 持田記念研究助成 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • 新規腎臓オルガノイドを用いた病態モデルへの応用

    2020.4 - 2021.3

    持田記念医学薬学振興財団  2020 年度 持田記念研究助成 

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    Grant type:Competitive 

  • プロスタシンを軸とした肝臓インスリン感受性および膵臓インスリン分泌の調節機構

    2020.4 - 2021.3

    日本応用酵素協会Front Runner of Future Diabetes Research 

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    Grant type:Competitive 

  • ヒトiPS 細胞由来腎臓オルガノイドの病態モデルへの応用

    2020.4 - 2021.3

    テルモ生命科学振興財団  再生医療研究

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    Grant type:Competitive 

  • ヒトiPS由来腎臓オルガノイドを用いた高尿酸腎障害モデルの確立

    2020.4 - 2021.3

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    Grant type:Competitive 

  • ヒトiPS細胞由来腎臓オルガノイドを用いたIgA腎症の非観血的診断法の開発

    2020.4 - 2021.3

    近藤記念医学財団  2020年度 学術奨励賞 

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    Grant type:Competitive 

  • Advances in Research Conference Early Program Travel Support Travel Grant

    2017.11

    American Society of Nephrology 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • Advances in Research Conference Early Program Travel Support Travel Grant

    2017.11

    American Society of Nephrology 

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    Grant type:Competitive 

  • マウスモデルを用いた急性腎障害およびその回復機序の解明

    2017.4 - 2019.3

    日本学術振興会  海外特別研究員 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • マウスモデルを用いた急性腎障害およびその回復機序の解明

    2017.4 - 2019.3

    日本学術振興会  海外特別研究員 

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    Grant type:Competitive 

  • ASN Campbell Fellows Travel Support Travel Grant

    2016.11

    American Society of Nephrology 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • ASN Campbell Fellows Travel Support Travel Grant

    2016.11

    American Society of Nephrology 

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    Grant type:Competitive 

  • ASN Kidney Week and the Kidney STARS program Travel Grant

    2015.11

    American Society of Nephrology 

  • ASN Kidney Week and the Kidney STARS program Travel Grant

    2015.11

    American Society of Nephrology 

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    Grant type:Competitive 

  • プロスタシン発現・活性調節メカニズムの解明による新規糖尿病治療開発の分子基盤

    2015.4 - 2018.3

    平成27年度科学研究費助成事業 基金・若手(B) 課題番号:15K19510 ※留学のため辞退 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • プロスタシン発現・活性調節メカニズムの解明による新規糖尿病治療開発の分子基盤

    2015.4 - 2018.3

    平成27年度科学研究費助成事業 基金・若手(B) 課題番号:15K19510 ※留学のため辞退 

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    Grant type:Competitive 

  • 腎障害後の線維化および再生メカニズムの解明

    2015.4 - 2017.3

    上原記念生命科学財団  ポストドクトラルフェローシップ 

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    Grant type:Competitive 

  • 腎障害後の線維化および再生メカニズムの解明

    2015.4 - 2017.3

    上原記念生命科学財団  ポストドクトラルフェローシップ 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • 腎障害後の再生メカニズムによる腎不全患者への治療法開発の分子基盤

    2015.4 - 2016.3

    中冨健康科学振興財団  留学助成金 

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    Grant type:Competitive 

  • マウスモデルを用いた急性腎障害およびその回復機序の解明

    2015.4 - 2016.3

    持田記念医学薬学振興財団  留学助成金 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • プロスタシン発現調節メカニズムの解明による慢性炎症を標的とした新規糖尿病治療法開発の分子基盤

    2015.4 - 2016.3

    かなえ医薬振興財団 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • プロスタシン発現調節メカニズムの解明による新規糖尿病治療薬開発の分子基盤

    2015.4 - 2016.3

    日本応用酵素協会Front Runner of Future Diabetes Research 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • プロスタシンによる慢性炎症を標的とした新規メタボリック症候群治療薬開発の分子基盤

    2015.4 - 2016.3

    ノバルティス科学振興財団 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • 腎障害後の再生メカニズムによる腎不全患者への治療法開発の分子基盤

    2015.4 - 2016.3

    中冨健康科学振興財団  留学助成金 

      More details

    Authorship:Principal investigator  Type of fund::Science research expense

  • マウスモデルを用いた急性腎障害およびその回復機序の解明

    2015.4 - 2016.3

    持田記念医学薬学振興財団  留学助成金 

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    Grant type:Competitive 

  • プロスタシン発現調節メカニズムの解明による新規糖尿病治療薬開発の分子基盤

    2015.4 - 2016.3

    日本応用酵素協会Front Runner of Future Diabetes Research 

      More details

    Grant type:Competitive 

  • プロスタシンによる慢性炎症を標的とした新規メタボリック症候群治療薬開発の分子基盤

    2015.4 - 2016.3

    ノバルティス科学振興財団 

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    Grant type:Competitive 

  • プロスタシン発現調節メカニズムの解明による慢性炎症を標的とした新規糖尿病治療法開発の分子基盤

    2015.4 - 2016.3

    かなえ医薬振興財団 

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    Grant type:Competitive 

  • プロスタシン発現調節メカニズムの解明による新規糖尿病治療開発の分子基盤

    2014.4 - 2016.3

    万有生命科学振興国際交流財団 ※留学決定により辞退 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • プロスタシン発現調節メカニズムの解明による新規糖尿病治療開発の分子基盤

    2014.4 - 2016.3

    万有生命科学振興国際交流財団 ※留学決定により辞退 

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    Grant type:Competitive 

  • プロスタシン発現調節メカニズムの解明による慢性炎症を標的とした治療法の開発

    2014.4 - 2015.3

    先進医薬研究振興財団 循環医薬分野 若手研究者助成(2014) 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • プロスタシン発現調節メカニズムの解明による新規糖尿病治療開発の分子基盤

    2014.4 - 2015.3

    武田科学振興財団 

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    Authorship:Principal investigator  Type of fund::Science research expense

  • プロスタシン発現調節メカニズムの解明による新規糖尿病治療開発の分子基盤

    2014.4 - 2015.3

    武田科学振興財団 

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    Grant type:Competitive 

  • プロスタシン発現調節メカニズムの解明による慢性炎症を標的とした治療法の開発

    2014.4 - 2015.3

    先進医薬研究振興財団 循環医薬分野 若手研究者助成(2014) 

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    Grant type:Competitive 

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Papers

  • Membrane protease prostasin promotes insulin secretion by regulating the epidermal growth factor receptor pathway Reviewed Major achievement

    Toshihisa Ishii, Yoshikazu Miyasato, Masashi Ichijo, Kohei Uchimura, Fumihiko Furuya

    Scientific Reports   13 ( 1 )   2023.6(  eISSN:2045-2322 )

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Prostasin (PRSS8) is a serine protease that metabolizes and moderates the effect of specific substrates. Epidermal growth factor receptor (EGFR), which modulates insulin secretion and pancreatic β-cell proliferation, is regulated via proteolytic shedding by PRSS8. We first detected PRSS8 expression in β-cells of pancreatic islets of mice. To better understand the molecular processes involved in PRSS8-associated insulin secretion, pancreatic β-cell-specific PRSS8 knockout (βKO) and PRSS8-overexpressing (βTG) male mice were generated. We found that glucose intolerance and reduction in glucose-stimulated insulin secretion developed in βKO mice compared with the control subjects. A higher response to glucose was noted in islets retrieved from βTG mice. Erlotinib, a specific blocker of EGFR, blocks EGF- and glucose-stimulated secretion of insulin among MIN6 cells, and glucose improves EGF release from β-cells. After silencing PRSS8 in MIN6 cells, glucose-stimulated insulin secretion decreased, and EGFR signaling was impaired. Conversely, overexpression of PRSS8 in MIN6 cells induced higher concentrations of both basal and glucose-stimulated insulin secretion and increased phospho-EGFR concentrations. Furthermore, short-term exposure to glucose improved the concentration of endogenous PRSS8 in MIN6 cells through inhibition of intracellular degradation. These findings suggest that PRSS8 is involved in glucose-dependent physiological regulation of insulin secretion via the EGF–EGFR signaling pathway in pancreatic β-cells.

    DOI: 10.1038/s41598-023-36326-7

    Other Link: https://www.nature.com/articles/s41598-023-36326-7

  • Single-cell RNA Sequencing and Kidney Organoid Differentiation Reviewed

    Kohei Uchimura

    Clin Exp Nephrol.   27 ( 7 )   585 - 592   2023

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-023-02359-5.

  • Impact of renal function on the prognosis of patients receiving Atezolizumab / Bevacizumab combination therapy and Lenvatinib monotherapy for unresectable hepatocellular carcinoma. Reviewed

    1. H Takada, K Yamashita, L Osawa, Y Komiyama, N Nakakuki, M Muraoka, Y Suzuki, M Sato, S Takano, M Fukasawa, T Yamaguchi, S Maekawa, K Takahashi, K Uchimura, N Enomoto

    Oncology.   2023

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Intelectin1 ameliorates macrophage activation via inhibiting the nuclear factor kappa B pathway. Reviewed

    Kobayashi H, Uchimura K, Ishii T, Takahashi K, Mori K, Tsuchiya K, Furuya F.

    ENDOCRINE JOURNAL   2021.12( ISSN:0918-8959 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Development of the Diabetic Kidney Disease Mouse Model Culturing Embryos in α-Minimum Essential Medium In Vitro, and Feeding Barley Diet Attenuated the Pathology. Reviewed

    Ishiyama S, Kimura M, Nakagawa T, Fujimoto Y, Uchimura K, Kishigami S, Mochizuki K

    Frontiers in Endocrinology   2021.11( ISSN:1664-2392 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Hyperthyroidism exacerbates ischemic reperfusion injury in the kidney. Reviewed

    Yamaguchi Y, Uchimura K, Takahashi K, Ishii T, Hanai S, Furuya F

    ENDOCRINE JOURNAL   2021.10( ISSN:0918-8959 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Liver-specific overexpression of prostasin attenuates high-fat diet-induced metabolic dysregulation in mice. Reviewed

    Sekine T, Takizawa S, Uchimura K, Miyazaki A, Tsuchiya K.

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Hypoxia-induced thyroid hormone receptor expression regulates cell-cycle progression in renal tubule epithelial cells. Reviewed

    Hanai S, Uchimura K, Takahashi K, Ishii T, Mitsui T, Furuya F

    ENDOCRINE JOURNAL   2021.6( ISSN:0918-8959 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats. Reviewed

    Mizumoto T, Kakizoe Y, Nakagawa T, Iwata Y, Miyasato Y, Uchimura K, Adachi M, Deng Q, Hayata M, Morinaga J, Miyoshi T, Izumi Y, Kuwabara T, Sakai Y, Tomita K, Kitamura K, Mukoyama M.

    JOURNAL OF PHARMACOLOGICAL SCIENCES   2021.4( ISSN:1347-8613 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling Reviewed

    Cell Reports   2020( ISSN:2211-1247 )

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury. Reviewed

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   2020( ISSN:0027-8424 )

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  • Graft immaturity and safety concerns in transplanted human kidney organoids. Reviewed

    EXPERIMENTAL AND MOLECULAR MEDICINE   2019( ISSN:1226-3613 )

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  • The single-cell transcriptomic landscape of early human diabetic nephropathy. Reviewed

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   2019( ISSN:0027-8424 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study.

    NEPHROLOGY DIALYSIS TRANSPLANTATION   2019( ISSN:0931-0509 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics. Reviewed

    Cell Stem Cell   2018( ISSN:1934-5909 )

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats. Reviewed

    Oxidative Medicine and Cellular Longevity   2018( ISSN:1942-0900 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response. Reviewed

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   2018( ISSN:1046-6673 )

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  • Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases. Reviewed

    Scientific Reports   2016( ISSN:2045-2322 )

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  • Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model. Reviewed

    JOURNAL OF PHARMACOLOGICAL SCIENCES   2016( ISSN:1347-8613 )

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  • A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity. Reviewed

    JOURNAL OF PHARMACOLOGICAL SCIENCES   2016( ISSN:1347-8613 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Nihon Rinsho Major achievement

    Prostasin (PRSS8) as a new pathological factor   73 ( 3 )   523 - 533   2015.3

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    Authorship:Lead author   Language:Japanese   Publishing type:(MISC) Introduction and explanation (scientific journal)  

  • The Serine Protease Inhibitor Camostat Mesilate Attenuates the Progression of Chronic Kidney Disease through its Antioxidant Effects.  Reviewed

    NEPHRON   129 ( 3 )   223 - 232   2015.3( ISSN:1660-8151 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway. Reviewed

    Cell Metabolism   9 ( 4 )   712 - 721   2014.4( ISSN:1550-4131 )

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  • The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling. Reviewed Major achievement

    Nature Communications   5 ( 3428 )   2014.4( ISSN:2041-1723 )

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • The antifibrotic effect of a serine protease inhibitor in the kidney. Reviewed

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   2013( ISSN:1931-857X )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Effect of a serine protease inhibitor on the progression of chronic renal failure. Reviewed

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   2012( ISSN:1931-857X )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats. Reviewed

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   2012( ISSN:1931-857X )

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Regulation of adrenal aldosterone production by serine protease prostasin. Reviewed

    AAPS Journal   2010( ISSN:1550-7416 )

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    Language:English   Publishing type:Research paper (scientific journal)  

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Books and Other Publications

  • IgA腎症/紫斑病性腎炎

    内村幸平( Role: Single Work ,  Original_author: 内村幸平)

    南江堂  2023 

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    Language:Japanese   Book type:Scholarly book

  • 微小変化型ネフローゼ症候群

    内村幸平( Role: Single Work ,  Original_author: 内村幸平)

    南江堂  2023 

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    Language:Japanese   Book type:Scholarly book

  • 腎オルガノイドを用いたsingle cell RNA解析

    内村幸平( Role: Single Work ,  Original_author: 内村幸平)

    科学評論社  2023 

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    Language:Japanese  

  • 透析中に回路内白色血栓を生じた1例

    3. 小佐野慧一、内村幸平( Role: Joint Work)

    2023 

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    Language:Japanese  

  • オルガノイドを用いた尿細管障害モデル

    内村幸平( Role: Single Work)

    東京医学社  2022.12 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • CKDの管理、CKDの治療-1(食事、栄養指導)、CKDの治療-2(降圧療法)

    ( Role: Joint Work)

    2013 

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    Language:Japanese   Book type:Textbook, survey, introduction

  • CKDの管理、CKDの治療-1(食事、栄養指導)、CKDの治療-2(降圧療法)

    ( Role: Joint Work)

    2013 

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    Language:Japanese   Book type:Textbook, survey, introduction

  • 急性腎不全 

    ( Role: Joint Work)

    2012 

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    Language:Japanese   Book type:Textbook, survey, introduction

  • 急性腎不全

    ( Role: Joint Work)

    2012 

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    Language:Japanese   Book type:Textbook, survey, introduction

  • 水電解質・腎機能に関する最近の話題:キーワードから学ぶ 3)Prostasin 

    ( Role: Joint Work)

    2010 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • 水電解質・腎機能に関する最近の話題:キーワードから学ぶ 3)Prostasin

    ( Role: Joint Work)

    2010 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • 腎不全を合併した心不全

    ( Role: Joint Work)

    2009 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • 腎不全を合併した心不全

    ( Role: Joint Work)

    2009 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • コレステロール塞栓症の治療ガイド

    ( Role: Joint Work)

    2007 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • コレステロール塞栓症の治療ガイド

    ( Role: Joint Work)

    2007 

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    Language:Japanese   Book type:General book, introductory book for general audience

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Presentations

  • 疾患モデルを目指したヒトiPS細胞由来腎臓オルガノイドの成熟化

    内村幸平

    第22回日本再生医療学会総会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium workshop panel(public)  

  • iPSオルガノイドの腎臓病研究への応用

    内村幸平

    第52回日本腎臓学会西部学術大会  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Symposium workshop panel(public)  

  • ヒトiPS細胞由来腎臓オルガノイドのシングルセル解析と新規分化誘導法

    内村幸平

    第95回日本生化学会大会  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Symposium workshop panel(public)  

  • サクビトリルバルサルタン(ARNI)を安全に導入できた心不全増悪を繰り返す腹膜透析患者の一例

    内村 幸平, 諏訪 博史, 高橋 和也, 小西 真樹子, 石井 俊史, 大越 貴絵, 小佐野 慧一, 諏訪 裕美, 佐藤 泰代

    第67回日本透析医学会学術総会・総会  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Poster presentation  

  • Single Cell Sequencing and PSC-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling. Invited

    2022.6 

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    Event date: 2022.6

    Language:English   Presentation type:Oral presentation(keynote)  

  • 病態モデルに向けた 腎臓オルガノイド分化誘導法の改良

    内村幸平

    UJA OUTSTANDING PAPER AWARD  2022.5 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Oral presentation(keynote)  

  • プロスタシンによるインスリン分泌および膵β細胞増殖効果

    内村幸平、石井俊史、 一條昌志、古屋文彦

    第26回日本病態プロテアーゼ学会学術集会  2021.8 

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    Event date: 2021.8

    Language:Japanese   Presentation type:Oral presentation(general)  

  • プロスタシンによるインスリン分泌および膵β細胞増殖効果

    内村幸平, 石井俊史, 一條昌志, 古屋文彦

    第26回日本病態プロテアーゼ学会学術集会  2021.8 

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    Language:Japanese   Presentation type:Oral presentation(general)  

  • 術前抗体価著明高値(1024倍)血液型不適合腎移植の一例

    内村幸平, 高橋和也, 朝比 奈謙吾, 小佐野慧一, 諏訪博史, 石井俊史, 小西真樹子, 神家満学, 古屋文彦

    第66回日本透析医学会学術集会・総会  2021.6 

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    Language:Japanese   Presentation type:Poster presentation  

  • 術前抗体価著明高値(1024倍)血液型不適合腎移植の一例

    内村幸平、高橋和也、朝比 奈謙吾、小佐野慧一、諏訪博史、石井俊史、小西真樹子、神家満学、古屋文彦

    第66回日本透析医学会学術集会・総会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Poster presentation  

  • 第63回日本腎臓学会学術総会

    2020 

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    Event date: 2020

    Language:English   Presentation type:Poster presentation  

  • 第63回日本腎臓学会学術総会

    第63回日本腎臓学会学術総会  2020 

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  • Improved Human Pluripotent Stem Cell-Derived Kidney Organoids for Modeling Collecting Duct Biology and Tubular Injury International conference

    ASN Kidney Week 2019  2019 

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    Event date: 2019

    Language:English   Presentation type:Oral presentation(general)  

  • Improved Human Pluripotent Stem Cell-Derived Kidney Organoids for Modeling Collecting Duct Biology and Tubular Injury International conference

    ASN Kidney Week 2019  2019 

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    Language:English   Presentation type:Oral presentation(general)  

  • Brain Derived Neurotrophic Factor (BDNF) Inhibition Dramatically Reduces Off-Target Cells in Kidney Organoid International conference

    ASN Kidney Week 2018  2018 

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    Event date: 2018

    Language:English   Presentation type:Poster presentation  

  • Brain Derived Neurotrophic Factor (BDNF) Inhibition Dramatically Reduces Off-Target Cells in Kidney Organoid International conference

    ASN Kidney Week 2018  2018 

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    Language:English   Presentation type:Poster presentation  

  • Rabbit Monoclonal Antibody (RabMAb) Validation in Mouse and Human Kidney International conference

    RBK (ReBuilding a Kidney) executive meeting  2016 

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    Event date: 2016

    Language:English   Presentation type:Poster presentation  

  • Rabbit Monoclonal Antibody (RabMAb) Validation in Mouse and Human Kidney International conference

    RBK (ReBuilding a Kidney) executive meeting  2016 

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    Language:English   Presentation type:Poster presentation  

  • 肝臓におけるプロスタシン(PRSS8)発現低下を介した飽食・肥満による糖尿病発症新機序の解明

    第112回 日本内科学会総会・講演会  2015.4  日本内科学会

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都  

  • 肝臓におけるプロスタシン(PRSS8)発現低下を介した飽食・肥満による糖尿病発症新機序の解明

    第112回 日本内科学会総会・講演会  2015.4  日本内科学会

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    Event date: 2015.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都  

  • プロスタシンによるTLR4の発現制御を介した肝臓におけるインスリン抵抗性発症機序の解明 Invited

    第18回 日本心血管内分泌代謝学会学術総会  2014.11  日本心血管内分泌代謝学会

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

    Venue:横浜  

  • プロスタシンによるTLR4の発現制御を介した肝臓におけるインスリン抵抗性発症機序の解明 Invited

    第18回 日本心血管内分泌代謝学会学術総会  2014.11  日本心血管内分泌代謝学会

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    Language:Japanese   Presentation type:Oral presentation(invited, special)  

    Venue:横浜  

  • プロスタシンの新たな生理的機能の解明 ~TLR4の切断を介した肝臓におけるインスリン抵抗性に対する防御機構~

    第19回 日本病態プロテアーゼ学会学術集会  2014.8  日本病態プロテアーゼ学会

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    Event date: 2014.8

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪  

  • プロスタシンの新たな生理的機能の解明 ~TLR4の切断を介した肝臓におけるインスリン抵抗性に対する防御機構~

    第19回 日本病態プロテアーゼ学会学術集会  2014.8  日本病態プロテアーゼ学会

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪  

  • The Serine Protease Prostasin Regulates Hepatic Insulin Sensitivity by Modulating TLR4 Signaling International conference Major achievement

    American Diabetes Association 74th Scientific Sessions,  2014.6 

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    Event date: 2014.6

    Language:English   Presentation type:Poster presentation  

  • The Serine Protease Prostasin Regulates Hepatic Insulin Sensitivity by Modulating TLR4 Signaling International conference

    American Diabetes Association 74th Scientific Sessions,  2014.6  American Diabetes Association

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    Language:English   Presentation type:Poster presentation  

    Venue:San Francisco, USA  

  • The Serine Protease Prostasin Regulates Hepatic Insulin Sensitivity by Modulating TLR4 Signaling International conference

    9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress  2014 

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    Event date: 2014

    Language:English   Presentation type:Poster presentation  

  • The Serine Protease Prostasin Regulates Hepatic Insulin Sensitivity by Modulating TLR4 Signaling International conference

    9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress  2014  American Diabetes Association

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    Language:English   Presentation type:Poster presentation  

    Venue:San Francisco, USA  

  • A synthetic serine protease inhibitor camostat mesilate inhibited the proteolytic activation of γENaC in the kidney of the aldosterone infused rats International conference

    Kidney Week 2011: American Society of Nephrology 44th Annual Meeting,  2011 

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    Event date: 2011

    Language:English   Presentation type:Poster presentation  

  • A synthetic serine protease inhibitor camostat mesilate inhibited the proteolytic activation of γENaC in the kidney of the aldosterone infused rats International conference

    Kidney Week 2011: American Society of Nephrology 44th Annual Meeting,  2011 

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    Language:English   Presentation type:Poster presentation  

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The total number of announcement other than the above

  • 2014

    Total number of non-preannounced events:2  Number of main presenters:2  Number of presenters other than main person:0

Awards

  • 第65回日本腎臓学会学術総会 大島賞

    2022.6   日本腎臓学会  

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • 第65回日本腎臓学会学術総会 大島賞

    2022.6   日本腎臓学会  

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • 海外日本人研究者ネットワーク(UJA)論文賞

    2022.5   海外日本人研究者ネットワーク(UJA)  

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    Award type:Award from international society, conference, symposium, etc. 

  • 海外日本人研究者ネットワーク(UJA)論文賞

    2022   海外日本人研究者ネットワーク(UJA)  

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  • Front Runner of Future Diabetes Research

    2015.7   Japan Foundation for Applied Enzymology  

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • Front Runner of Future Diabetes Research

    2015.7   Japan Foundation for Applied Enzymology  

    内村幸平

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    プロスタシン発現調節メカニズムの解明による新規糖尿病治療薬開発の分子基盤

  • CVEM Young Investigator Award 2014

    2014.11   the Society of Cardiovascular Endocrinology and Metabolism (CVEM)  

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  • CVEM Young Investigator Award 2014

    2014.11   the Society of Cardiovascular Endocrinology and Metabolism (CVEM)  

    内村幸平

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    プロスタシンによるTLR4の発現制御を介した肝臓におけるインスリン抵抗性発症機序の解明

  • Young Investigator’s Award of JSPP (2014)

    2014.8   Japanese Society for Proteases in Pathophysiology  

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  • Young Investigator’s Award of JSPP (2014)

    2014.8   Japanese Society for Proteases in Pathophysiology  

    内村幸平

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    プロスタシンの新たな生理的機能の解明
    ~TLR4の切断を介した肝臓におけるインスリン抵抗性に対する防御機構~

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Teaching Experience (On-campus)

  • Internal Medicine 3 (Basic Clinical Clerkship)

    2023Year

  • 高血圧と腎硬化症 Major achievement

    2023Year  Type of subject:Professional education (undergraduate)

  • 尿細管機能と疾患 Major achievement

    2023Year  Type of subject:Professional education (undergraduate)

  • コース3グループ学習

    2022Year

  • 高血圧と腎硬化症 Major achievement

    2021Year  Type of subject:Professional education (undergraduate)

  • 尿細管機能と疾患 Major achievement

    2021Year  Type of subject:Professional education (undergraduate)

  • 高血圧と腎硬化症 Major achievement

    2020Year  Type of subject:Common education (undergraduate)

  • 尿細管機能と疾患

    2020Year

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Guidance results

  • 2021

    Type:Achievement of student guidance (graduate school)

    Number of people receiving guidance :2people 

Review of master's and doctoral thesis

  • 2022

    Examiner classification:Second reader

    Doctoral :1people