コロンビア大学   医学部   ポストドクトラルリサーチフェロー

2009.4 - 2013.3

日本学術振興会   海外特別研究員

2011.4 - 2013.3

東京医科歯科大学医学部附属病院   糖尿病・内分泌・代謝内科   助教

2013.4 - 2017.3

公益財団法人 山梨厚生会 山梨厚生病院   糖尿病内科   医員

2017.4 - 2018.3

山梨大学医学部   内科学講座 糖尿病・内分泌内科学教室   講師

2021.4

山梨大学医学部   内科学講座第3教室   講師

2018.4 - 2021.3

Japanese Type 1 Diabetes Database Study (TIDE-J): rationale and study design Reviewed

Diabetology International   13 ( 1 )   288 - 294   2021.9

Gestational body weight gain and risk of low birth weight or macrosomia in women of Japan: a nationwide cohort study Reviewed

INTERNATIONAL JOURNAL OF OBESITY   45 ( 12 )   2666 - 2674   2021.9( ISSN：0307-0565 )

Liver-specific overexpression of prostasin attenuates high-fat diet-induced metabolic dysregulation in mice Reviewed

Sekine T, Takizawa S, Uchimura K, Miyazaki A, Tsuchiya K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   22 ( 15 )   8314   2021.8

Ipragliflozin Ameliorates Diabetic Nephropathy Associated with Perirenal Adipose Expansion in Mice Reviewed

Okuma H, Mori K, Nakamura S, Sekine T, Ogawa Y, Tsuchiya K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   22 ( 14 )   7329   2021.7

Age-associated decline of monocyte insulin sensitivity in diabetic and healthy individuals Reviewed

Nakamura S, Mori K, Okuma H, Sekine T, Miyazaki A, Tsuchiya K

Diabetes & Vascular Disease Research   18 ( 1 )   1479164121989281   2021.2( ISSN：1479-1641 )

Acute Kidney Injury with Hemolysis after Glycerin Enema-induced Rectal Injury in a Patient with Type 2 Diabetes Reviewed

Hayashida R, Tsuchiya K, Nakamura S, Harima N, Ichijo M, Furuya F, Kitamura K

INTERNAL MEDICINE   59 ( 13 )   1659   2020.7( ISSN：0918-2918 )

Dulaglutide improves glucocorticoid-induced hyperglycemia in inpatient care and reduces dose and injection frequency of insulin Reviewed

Uchinuma H, Ichijo M, Harima N, Tsuchiya K

BMC Endocrine Disorders   22 ( 15 )   8314   2020.5

Follicle-stimulating Hormone-secreting Pituitary Adenoma Accompanied by Painful Thyroiditis Reviewed

Ichijo M, Tsuchiya K, Kasai T, Inoshita N, Yoshimoto H, Yamada S, Kitamura K

INTERNAL MEDICINE   59 ( 4 )   545 - 550   2020.2( ISSN：0918-2918 )

Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice Reviewed

Mori K, Tsuchiya K, Nakamura S, Miyachi Y, Shiba K, Ogawa Y, Kitamura K

Cardiovascular Diabetology   18 ( 1 )   83   2019.6

Forkhead box class O family member proteins: The biology and pathophysiological roles in diabetes Reviewed

Tsuchiya K, Ogawa Y

Journal of Diabetes Investigation   8 ( 6 )   726 - 734   2017.11

Molecular characteristics of the KCNJ5 mutated aldosterone-producing adenomas Reviewed

Murakami M, Yoshimoto T, Nakabayashi K, Nakano Y, Fukaishi T, Tsuchiya K, Minami I, Bouchi R, Okamura K, Fujii Y, Hashimoto K, Hata KI, Kihara K, Ogawa Y

ENDOCRINE-RELATED CANCER   8 ( 1 )   16113   2017.10( ISSN：1351-0088 )

Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis Reviewed

Komiya C, Tanaka M, Tsuchiya K, Shimazu N, Mori K, Furuke S, Miyachi Y, Shiba K, Yamaguchi S, Ikeda K, Ochi K, Nakabayashi K, Hata KI, Itoh M, Suganami T, Ogawa Y

Scientific Reports   7   44754   2017.5( ISSN：2045-2322 )

Roles for Cell-Cell Adhesion and Contact in Obesity-Induced Hepatic Myeloid Cell Accumulation and Glucose Intolerance Reviewed

Miyachi Y, Tsuchiya K, Komiya C, Shiba K, Shimazu N, Yamaguchi S, Deushi M, Osaka M, Inoue K, Sato Y, Matsumoto S, Kikuta J, Wake K, Yoshida M, Ishii M, Ogawa Y

Cell Reports   18 ( 11 )   2766 - 2779   2017.5( ISSN：2211-1247 )

Expression of inflammation-related genes in aldosterone-producing adenomas with KCNJ5 mutation Reviewed

Murakami M, Yoshimoto T, Nakano Y, Tsuchiya K, Minami I, Bouchi R, Fujii Y, Nakabayashi K, Hashimoto K, Hata KI, Kihara K, Ogawa Y

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   476 ( 4 )   614 - 619   2016.8( ISSN：0006-291X )

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice Reviewed

Westerterp M, Tsuchiya K, Tattersall IW, Fotakis P, Bochem AE, Molusky MM, Ntonga V, Abramowicz S, Parks JS, Welch CL, Kitajewski J, Accili D, Tall AR

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   36 ( 7 )   1328 - 37   2016.7( ISSN：1079-5642 )

A Case of Cushing's Syndrome with Multiple Adrenocortical Adenomas Composed of Compact Cells and Clear Cells Reviewed

Asakawa M, Yoshimoto T, Ota M, Numasawa M, Sasahara Y, Takeuchi T, Nakano Y, Oohara N, Murakami M, Bouchi R, Minami I, Tsuchiya K, Hashimoto K, Izumiyama H, Kawamura N, Kihara K, Negi M, Akashi T, Eishi Y, Sasano H, Ogawa Y

ENDOCRINE PATHOLOGY   27 ( 2 )   136 - 41   2016.6( ISSN：1046-3976 )

Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction Reviewed

Komiya C, Tsuchiya K, Shiba K, Miyachi Y, Furuke S, Shimazu N, Yamaguchi S, Kanno K, Ogawa Y

PLoS One   11 ( 3 )   e0151511   2016.3( ISSN：1932-6203 )

Lifestyle-related diseases and an inter-organ metabolic network Reviewed

Miyachi Y, Tsuchiya K, Ogawa Y

Clinical Calcium   26 ( 3 )   392 - 8   2016.3

Integration of transcriptome and methylome analysis of aldosterone-producing adenomas Reviewed

Murakami M, Yoshimoto T, Nakabayashi K, Tsuchiya K, Minami I, Bouchi R, Izumiyama H, Fujii Y, Abe K, Tayama C, Hashimoto K, Suganami T, Hata K, Kihara K, Ogawa Y

EUROPEAN JOURNAL OF ENDOCRINOLOGY   173 ( 2 )   185 - 95   2015.8( ISSN：0804-4643 )

A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism Reviewed

Cook JR, Matsumoto M, Banks AS, Kitamura T, Tsuchiya K, Accili D

DIABETES   64 ( 6 )   1951 - 65   2015.6( ISSN：0012-1797 )

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures Reviewed

Bouchi R, Foo KS, Hua H, Tsuchiya K, Ohmura Y, Sandoval PR, Ratner LE, Egli D, Leibel RL, Accili D

Nature Communications   30 ( 5 )   4242   2014.6( ISSN：2041-1723 )

Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice Reviewed

Tsuchiya K, Westerterp M, Murphy AJ, Subramanian V, Ferrante AW Jr, Tall AR, Accili D

CIRCULATION RESEARCH   112 ( 7 )   992 - 1003   2013.3( ISSN：0009-7330 )

Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance Reviewed

Tsuchiya K, Accili D

DIABETES   62 ( 5 )   1478 - 89   2013.3( ISSN：0012-1797 )

Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment Reviewed

Li X, Gonzalez O, Shen X, Barnhart S, Kramer F, Kanter JE, Vivekanandan-Giri A, Tsuchiya K, Handa P, Pennathur S, Kim F, Coleman RA, Schaffer JE, Bornfeldt KE

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   33 ( 2 )   232 - 40   2013.2( ISSN：1079-5642 )

Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene Reviewed

Qiang L, Tsuchiya K, Kim-Muller JY, Lin HV, Welch C, Accili D

JOURNAL OF BIOLOGICAL CHEMISTRY   287 ( 17 )   13944 - 51   2012.4( ISSN：0021-9258 )

FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis Reviewed

Tsuchiya K, Tanaka J, Shuiqing Y, Welch CL, DePinho RA, Tabas I, Tall AR, Goldberg IJ, Accili D

Cell Metabolism   15 ( 3 )   372 - 81   2012.3( ISSN：1550-4131 )

Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis Reviewed

Tsuchiya K, Banks AS, Liang CP, Tabas I, Tall AR, Accili D

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   31 ( 12 )   2920 - 8   2011.12( ISSN：1079-5642 )

Clinicopathological features of primary aldosteronism associated with subclinical Cushing's syndrome Reviewed

Hiraishi K, Yoshimoto T, Tsuchiya K, Minami I, Doi M, Izumiyama H, Sasano H, Hirata Y

ENDOCRINE JOURNAL   58 ( 7 )   543 - 51   2011.4( ISSN：0918-8959 )

Improvement of endothelial function in patients with hypertension and type 2 diabetes after treatment with telmisartan Reviewed

Wago T, Yoshimoto T, Akaza I, Tsuchiya K, Izumiyama H, Doi M, Hirata Y

HYPERTENSION RESEARCH   33 ( 8 )   796 - 801   2010.8( ISSN：0916-9636 )

Endothelial dysfunction aassociated with hypercortisolism is reversible in Cushing's syndrome Reviewed

Akaza I, Yoshimoto T, Tsuchiya K, Hirata Y

ENDOCRINE JOURNAL   57 ( 3 )   245 - 52   2009.12( ISSN：0918-8959 )

Acromegaly associated with multiple tumors Reviewed

Sekizawa N, Hayakawa E, Tsuchiya K, Yoshimoto T, Akashi T, Fujii T, Yamada S, Hirata Y

INTERNAL MEDICINE   48 ( 15 )   1273 - 8   2009.8( ISSN：0918-2918 )

Pioglitazone improves endothelial function with increased adiponectin and high-density lipoprotein cholesterol levels in type 2 diabetes Reviewed

Tsuchiya K, Akaza I, Yoshimoto T, Hirata Y

ENDOCRINE JOURNAL   56 ( 5 )   691 - 8   2009.6( ISSN：0918-8959 )

Improvement of congestive heart failure after octreotide and transsphenoidal surgery in a patient with acromegaly Reviewed

Akaza I, Tsuchiya K, Akaza M, Sugiyama T, Izumiyama H, Doi M, Yoshimoto T, Hirata Y

INTERNAL MEDICINE   48 ( 9 )   697 - 700   2009.5( ISSN：0918-2918 )

Endothelial dysfunction is related to aldosterone excess and raised blood pressure Reviewed

Tsuchiya K, Yoshimoto T, Hirata Y

ENDOCRINE JOURNAL   56 ( 4 )   553 - 9   2009.4( ISSN：0918-8959 )

Improvement of endothelial dysfunction in acromegaly after transsphenoidal surgery Reviewed

Sakai H, Tsuchiya K, Nakayama C, Iwashima F, Izumiyama H, Doi M, Yoshimoto T, Tsujino M, Yamada S, Hirata Y

ENDOCRINE JOURNAL   55 ( 5 )   853 - 9   2008.5( ISSN：0918-8959 )

Late-night salivary cortisol as a screening test for the diagnosis of Cushing's syndrome in Japan Reviewed

Doi M, Sekizawa N, Tani Y, Tsuchiya K, Kouyama R, Tateno T, Izumiyama H, Yoshimoto T, Hirata Y

ENDOCRINE JOURNAL   55 ( 1 )   121 - 6   2008.1( ISSN：0918-8959 )

Advanced endothelial dysfunction in diabetic patients with multiple risk factors; importance of insulin resistance Reviewed

Tsuchiya K, Nakayama C, Iwashima F, Sakai H, Izumiyama H, Doi M, Hirata Y

Journal of Atherosclerosis and Thrombosis   14 ( 6 )   303 - 9   2007.12( ISSN：1340-3478 )

Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice Reviewed

Tsuchiya K, Sakai H, Suzuki N, Iwashima F, Yoshimoto T, Shichiri M, Hirata Y

ENDOCRINOLOGY   148 ( 10 )   4548 - 56   2007.10( ISSN：0013-7227 )

Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice Reviewed

Tsuchiya K, Sakai H, Suzuki N, Iwashima F, Yoshimoto T, Shichiri M, Hirata Y

ENDOCRINOLOGY   148 ( 10 )   4548 - 56   2007.10( ISSN：0013-7227 )

Angiotensin II induces monocyte chemoattractant protein-1 expression via a nuclear factor-kappaB-dependent pathway in rat preadipocytes Reviewed

Tsuchiya K, Yoshimoto T, Hirono Y, Tateno T, Sugiyama T, Hirata Y

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM   291 ( 4 )   E771 - 8   2006.10( ISSN：0193-1849 )

A Case of acromegaly associated with subclinical Cushing's disease Reviewed

Tsuchiya K, Ohta K, Yoshimoto T, Doi M, Izumiyama H, Hirata Y

ENDOCRINE JOURNAL   53 ( 5 )   679 - 85   2006.10( ISSN：0918-8959 )

Malignant gastric carcinoid causing ectopic ACTH syndrome: discrepancy of plasma ACTH levels measured by different immunoradiometric assays Reviewed

Tsuchiya K, Minami I, Tateno T, Izumiyama H, Doi M, Nemoto T, Mae S, Kasuga T, Osamura RY, Oki Y, Hirata Y

ENDOCRINE JOURNAL   52 ( 6 )   743 - 50   2005.12( ISSN：0918-8959 )

Aldosterone increases osteopontin gene expression in rat endothelial cells Reviewed

Sugiyama T, Yoshimoto T, Hirono Y, Suzuki N, Sakurada M, Tsuchiya K, Minami I, Iwashima F, Sakai H, Tateno T, Sato R, Hirata Y

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   336 ( 1 )   163 - 7   2005.10( ISSN：0006-291X )

Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells Reviewed

Sugiyama T, Yoshimoto T, Tsuchiya K, Gochou N, Hirono Y, Tateno T, Fukai N, Shichiri M, Hirata Y

ENDOCRINOLOGY   146 ( 9 )   3900 - 6   2005.9( ISSN：0013-7227 )

日本臨床分子医学会 第18回学術奨励賞

2015.4   日本臨床分子医学会  

土屋恭一郎

日本糖尿病・肥満動物学会 第7回若手研究奨励賞

2015.1   日本糖尿病・肥満動物学会  

土屋恭一郎

東京医科歯科大学医科同窓会 第26回研究奨励賞

2014.3   東京医科歯科大学医科同窓会  

土屋恭一郎

第8回高血圧と冠動脈疾患研究会 研究賞

2013.12   高血圧と冠動脈疾患研究会  

土屋恭一郎

2013 Columbia University Postdoc Research Award

2013.2  

Tsuchiya K

2010 Keystone Symposia Scholarship Award

2010.2  

Tsuchiya K

第17回東京高血圧研究会 若手研究奨励賞

2007.9   東京高血圧研究会  

土屋恭一郎

第7回日本NO学会学術集会 Travel Award

2007.5   日本NO学会  

土屋恭一郎