Updated on 2024/05/24

写真a

 
Saitoh Masao
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine (General Medical Science Center) Professor
Title
Professor

Degree

  • 博士(歯学) ( 東京医科歯科大学 )

Research Interests

  • cancer cell bioloby

  • Transforming growth factor-beta

  • signal transduction

  • epithelial mesenchymal transition

Research Projects

  • investigation of transdifferentiation of circulating tumor cells from invasive tumor cells

    2022.4 - 2025.3

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    Authorship:Principal investigator  Type of fund::Science research expense

  • investigation of transdifferentiation of circulating tumor cells from invasive tumor cells

    2022.4 - 2025.3

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    Authorship:Principal investigator  Type of fund::Science research expense

Papers

  • The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation. Reviewed

    2023.12

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    Language:English  

    DOI: 10.1016/j.jbc.2023.105580

  • Smad2Δexon3 and Smad3 have distinct properties in signal transmission leading to TGF-β-induced cell motility. Reviewed

    Yokoyama T, Kuga T, Itoh Y, Otake S, Omata C, Saitoh M, Miyazawa K

    JOURNAL OF BIOLOGICAL CHEMISTRY   2022.12( ISSN:0021-9258 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Indole-derived compound SIS3 targets a subset of activated Smad complexes. Reviewed

    Itoh Y, Sawaguchi T, Fu H, Omata C, Saitoh M, Miyazawa K.

    JOURNAL OF BIOCHEMISTRY   2022.12( ISSN:0021-924X )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Epithelial-Mesenchymal Transition by Synergy between Transforming Growth Factor-β and growth factors in Cancer Progression. Invited Reviewed

    Saitoh M

    Diagnostics   2022.9( ISSN:2075-4418 )

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Highly sensitive sex determination method using the exon 1 region of the amelogenin gene. Reviewed

    Fujimoto K, Fujii G, Shojo H, Nakanishi H, Kanzawa-Kiriyama H, Saitoh M, Yoshizawa K, Aono T, Horita T, Takada A, Saito K, Ueki K, Adachi N.

    Legal Medicine   2022.8( ISSN:1344-6223 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Ets family proteins regulate the EMT transcription factors Snail and ZEB in cancer cells Reviewed

    Ichikawa MK, Endo K, Itoh Y, Osada AH, Kimura Y, Ueki K, Yoshizawa K, Miyazawa K, Saitoh M.

    FEBS Open Bio   2022.4( ISSN:2211-5463 )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • High expression of protein tyrosine kinase 7 in oral squamous cell carcinoma: Clinicopathological correlation and prognosis relevance Reviewed

    3. Kimura Y, Yoshizawa K, Hotta-Osada A, Moroi A, Ishii H, Sakurai D, Saitoh M, Oishi N, Kondo T, Ueki K.

    Clinical and Experimental Dental Research   2022.4( ISSN:2057-4347 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • 歯科用高速切削機器使用時に発生する微粒子の可視化実験による検討 Reviewed

    日本口腔外科学会雑誌   2022.3( ISSN:0021-5163 )

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    Authorship:Last author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Loss of intercellular bridges in the depth of invasion measurement area is a novel negative prognostic factor for oral squamous cell carcinoma Reviewed

    Yoshizawa K, Kimura Y, Moroi A, Ishii H, Sakurai D, Saitoh M, Oishi N, Kondo K, Toyoura M, Ueki K.

    Oral Surgery Oral Medicine Oral Pathology Oral Radiology   2022.2( ISSN:2212-4403 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Direct and indirect roles of GRWD1 in the inactivation of p53 in cancer. Invited Reviewed

    2. Ichikawa MK, Saitoh M.

    JOURNAL OF BIOCHEMISTRY   2022.2( ISSN:0021-924X )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Dispersion of Aerosols Generated during Dental Therapy. Reviewed

    Tanabe Y. Maruoka Y. Kondo J. Yagi S. Chikaze D. Okamoto R. and Saitoh M

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH   18 ( 21 )   11279 - 11289   2021.10( ISSN:0960-3123 )

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

  • TGF-β-induced cell motility requires down-regulation of ARHGAPs to sustain Rac1 activity Reviewed

    JOURNAL OF BIOLOGICAL CHEMISTRY   2021.3( ISSN:0021-9258 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression. Reviewed

    Oncogenesis   10   1 - 15   2021.3( ISSN:2157-9024 )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nature  

  • ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus-dependent E-cadherin downregulation.

    CANCER SCIENCE   2021.1( ISSN:1347-9032 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Role of Platelet C-Type Lectin-Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma Reviewed

    JOURNAL OF BONE AND MINERAL RESEARCH   2020.9( ISSN:0884-0431 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Involvement of partial EMT in cancer progression Reviewed

    Masao Saitoh

    JOURNAL OF BIOCHEMISTRY   2018.10( ISSN:0021-924X )

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    Authorship:Lead author, Corresponding author   Language:English  

  • Reciprocal expression of Slug and Snail in human oral cancer cells Reviewed

    Ryosuke Nakamura, Hiroki Ishii, Kaori Endo, Asami Hotta, Eiji Fujii, Keiji Miyazawa, Masao Saitoh

    PLoS One   2018.7( ISSN:1932-6203 )

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    Authorship:Last author, Corresponding author   Language:English  

  • Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade Reviewed

    Keiko Suzuki, Tomoyuki Kawataki, Kaori Endo, Keiji Miyazawa, Hiroyuki Kinouchi, Masao Saitoh

    Oncology Letters   2018.1( ISSN:1792-1074 )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Smad3-STAT3 crosstalk in pathophysiological contexts. Reviewed

    Yuka Itoh Masao Saitoh Keiji Miyazawa

    ACTA BIOCHIMICA ET BIOPHYSICA SINICA   13   1 - 9   2017.11( ISSN:1672-9145 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion Reviewed

    Satoshi Furuya, Kaori Endo, Akiko Takahashi, Keiji Miyazawa, Masao Saitoh

    FEBS Open Bio   10 ( 7 )   1586 - 1597   2017.9( ISSN:2211-5463 )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cells. Reviewed

    Sinh ND, Endo K, Miyazawa K, Saitoh M

    CANCER SCIENCE   108 ( 5 )   952 - 960   2017.5( ISSN:1347-9032 )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB Reviewed

    Science Signaling   474 ( 10 )   eaak9397   2017.4( ISSN:1945-0877 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression. Reviewed

    Advances in Experimental Medicine and Biology   925   33 - 40   2016.6( ISSN:0065-2598 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma Reviewed

    PLoS One   11 ( 4 )   e0154   2016.4( ISSN:1932-6203 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression. Reviewed

    ONCOGENE   35 ( 8 )   1048 - 1057   2016.2( ISSN:0950-9232 )

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins. Reviewed

    FEBS LETTERS   590 ( 2 )   270 - 278   2016.1( ISSN:0014-5793 )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Maid is a negative regulator of transforming growth factor-β-induced cell migration Reviewed

    JOURNAL OF BIOCHEMISTRY   158 ( 5 )   435 - 444   2015.11( ISSN:0021-924X )

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    Language:English  

  • STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression Oncogene 2015 in press Reviewed

    Oncogene   2015.6

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    Language:English  

  • The epithelial–mesenchymal transition is regulated at the post-transcriptional levels by TGF- signaling during tumor progression Reviewed

    Cancer Sci   2015.6

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    Authorship:Lead author, Last author, Corresponding author   Language:English  

  • Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding. Virchows Arch. 2015 in press Reviewed

    VIRCHOWS ARCHIV   2015.6( ISSN:0945-6317 )

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    Language:English   Publishing type:Research paper (scientific journal)  

  • δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells. Reviewed

    Cancer Medicine   4   125 - 135   2015.6( ISSN:2045-7634 )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Epithelial splicing regulatory protein 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms. Reviewed

    J. Biol. Chem.   289   27386 - 27399   2014.10

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    Language:English  

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Books and Other Publications

  • Regulation of EMT by TGF- signaling in cancer cells

    ( Role: Joint Work)

    2017 

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    Language:English   Book type:Scholarly book

Presentations

  • TRIB1はC/EBPαの分解を介してTGF-β誘導性の細胞運動能を制御する

    日本癌学会総会  2022.10 

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation(general)  

  • Regulation of EMT transcription factors by Ets1

    2021.9 

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    Event date: 2021.9

    Language:English   Presentation type:Poster presentation  

  • Involvement of STAT3 and Ets1 in Snail induction by TGF-β

    2020.10 

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    Event date: 2020.10

    Language:English   Presentation type:Poster presentation  

  • A novel point mutation in EHF abolishes its capacity to inhibit cancer progression via regulating ETS-ZEB pathways

    The 78th Annual Meeting of the Japanese Cancer Association  2019.9 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Poster presentation  

  • Diagnosis of activated TGF-beta signaling in head and neck cancer by ambient mass spectrometry with machine learning

    The 78th Annual Meeting of the Japanese Cancer Association  2019.9 

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation(general)  

  • 口腔扁平上皮癌におけるSnail,Slugの役割の解析

    第55回口腔組織培養学会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 口腔扁平上皮癌細胞におけるFGFR1c isoformの機能解析

    第55回口腔組織培養学会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 頭頸部癌細胞における ZEBとETSファミリー分子の機能解析 International conference

    日本癌学会総会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Poster presentation  

  • がんのheterogeneityとEMTシグナル Invited

    日本口腔外科学会  2018.5 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

  • Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependently on ERK1/2 activity, in breast cancer cells International conference

    Masao Saitoh

    International EMT Conference  2017.12 

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    Event date: 2017.12

    Language:English   Presentation type:Oral presentation(general)  

  • がんのheterogeneityとEMTシグナル Invited

    日本口腔組織培養学会  2017.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

  • The roles of Ets1 and ESE1 in cancer cells

    2017.9 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 乳癌細胞におけるZEB1/ZEB2の発現調節機構

    がん分子標的治療学会  2017.6 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Poster presentation  

  • Epithelial Mesenchymal interaction in Development and Disease International conference

    2016.12 

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    Event date: 2016.12

    Language:English   Presentation type:Symposium workshop panel(public)  

  • STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression Oncogene 2015 in pr...

    2015.10 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation(general)  

  • STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression

    2015.9 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation(general)  

  • がん悪性化とスプライシング制御 

    斉藤正夫

    2011.11  岩田医科大学

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

    Venue:岩手医科大学  

  • がん-上皮細胞間相互作用による、がん細胞の浸潤促進機構       

    斉藤正夫

    2011.6  愛媛大学

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

    Venue:愛媛大学  

  • 上皮・間葉転換

    斉藤正夫

    2011.4  日本病理学会

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    Event date: 2011.4

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

    Venue:横浜  

  • FGF2 accelerates TGF-b-induced EMT

    2011.1 

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    Event date: 2011.1

    Language:English   Presentation type:Other  

  • 最近の再生医学研究から疾患へ

    斉藤正夫

    2009.5 

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    Event date: 2009.5

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

    Venue:福島県郡山市  

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Teaching Experience (On-campus)

  • Life Science I (Basic Medical Sciences: Physiological Regulation & Function)

    2023Year

  • Chemistry Major achievement

    2023Year

  • Life Science of the Human Body

    2023Year

Teaching achievements

  • 大学共通テスト本部委員

    2023.01.15

Social Activities

  • FMフジでのオープンキャンパス広報

    2023.11

  • FMフジでのオープンキャンパス広報

    2019.7

  • FMフジでのオープンキャンパス広報

    2017.6

  • FMフジでのオープンキャンパス広報

    Role(s): Appearance

    2013.11