Updated on 2025/05/01

写真a

 
Segawa Takahiro
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine (Center for Life Science Research) Senior Assistant Professor
Title
Senior Assistant Professor

Research History

  • University of Yamanashi   Senior Assistant Professor

    2021.4

  • University of Yamanashi

    2016.4 - 2021.3

  • 国立極地研究所　新領域融合研究センター   特任助教

    2012.4 - 2016.3

  • 国立極地研究所　新領域融合研究センター   特任研究員

    2005.10 - 2012.3

Degree

  • Ph.D ( 2005.9   Tokyo Institute of Technology )

Research Areas

  • Life Science / Ecology and environment

  • Environmental Science/Agriculture Science / Environmental dynamic analysis

Research Interests

  • 古代DNA

  • 環境動態解析

Subject of research

  • 古代DNA研究が切り開く更新世の絶滅大型哺乳類の解明

  • アイスコアの古代ゲノム解析が解き明かす気候変動と雪氷性シアノバクテリア群集変遷史

Research Projects

  • 永久凍土の物理プロセスに注目した太陽系岩石-氷天体の微生物ハビタットの探求 International coauthorship

    2024.4 - 2025.3

    自然科学研究機構  アストロバイオロジーセンタープロジェクト研究

  • 古代DNA解析技術を用いた絶滅哺乳類史の刷新  Major achievement

    Grant number：23KK0062  2023.9 - 2026.3

    日本学術振興会  科学研究費助成事業  国際共同研究加速基金(海外連携研究)

    瀬川 高弘, 村上 匠, 甲能 直樹, 森 宙史

    　 More details

    Authorship：Principal investigator 

  • 氷河・積雪生態系における雪氷藻類へのツボカビ感染症の動態解明

    Grant number：22H03731  2022.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    鏡味 麻衣子, 三木 健, 竹内 望, 植竹 淳, 村上 正志, 瀬川 高弘

    　 More details

    Authorship：Coinvestigator(s) 

  • The Formation of the Proto-Silk Roads: Integrated Research on Early Exploitation of Mountainous Areas in Central Asia

    Grant number：21H04357  2021.4 - 2026.3

    Japan Society for the Promotion of Science  Kanazawa University  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    　 More details

    Authorship：Coinvestigator(s) 

Papers

  • Validation and application of high-throughput quantitative PCR for the simultaneous detection of microbial source tracking markers in environmental water Reviewed International coauthorship

    Sunayana Raya, Bikash Malla, Ocean Thakali, Made Sandhyana Angga, Takahiro Segawa, Jeevan B. Sherchand, Eiji Haramoto

    Science of The Total Environment   940   173604 - 173604   2024.8( ISSN：0048-9697 )

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.scitotenv.2024.173604

  • Spread of antibiotic resistance genes to Antarctica by migratory birds Reviewed International coauthorship Major achievement

    923 ( 1 )   171345   2024.3( ISSN：0048-9697 )

    　More details

    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

  • The origins and diversification of Holarctic brown bear populations inferred from genomes of past and present populations Reviewed International coauthorship

    Takahiro Segawa, Alba Rey-Iglesia, Eline D Lorenzen, Michael V Westbury

    PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES   291 ( 2015 )   20232411   2024.1( ISSN：0962-8452 )

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi.org/10.1098/rspb.2023.2411

  • The origins and diversification of Holarctic brown bear populations inferred from genomes of past and present populations Reviewed International coauthorship

    Takahiro Segawa, Alba Rey-Iglesia, Eline D. Lorenzen, Michael V. Westbury

    Proceedings of the Royal Society B: Biological Sciences   291 ( 2015 )   2024.1( ISSN：0962-8452  eISSN：1471-2954 )

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Royal Society  

    The brown bear ( Ursus arctos ) is one of the survivors of the Late Quaternary megafauna extinctions. However, despite being widely distributed across the Holarctic, brown bears have experienced extensive range reductions, and even extirpations in some geographical regions. Previous research efforts using genetic data have provided valuable insights into their evolutionary history. However, most studies have been limited to contemporary individuals or mitochondrial DNA, limiting insights into population processes that preceded the present. Here, we present genomic data from two Late Pleistocene brown bears from Honshu, Japan and eastern Siberia, and combine them with published contemporary and ancient genomes from across the Holarctic range of brown bears to investigate the evolutionary relationships among brown bear populations through time and space. By including genomic data from Late Pleistocene and Holocene individuals sampled outside the current distribution range, we uncover diversity not present in contemporary populations. Notably, although contemporary individuals display geographically structured populations most likely driven by isolation-by-distance, this pattern varies among the ancient samples across different regions. The inclusion of ancient brown bears in our analysis provides novel insights into the evolutionary history of brown bears and contributes to understanding the populations and diversity lost during the Late Quaternary.

    DOI： 10.1098/rspb.2023.2411

    Other Link： https://royalsocietypublishing.org/doi/full-xml/10.1098/rspb.2023.2411

  • Abnormalities in CLEC-2 in a Patient with Gorham-Stout Disease: The First Case Report. Reviewed

    Saori Oishi, Nagaharu Tsukiji, Takahiro Segawa, Katsuhiro Takano, Norio Hasuda, Katsue Suzuki-Inoue

    Research and Practice in Thrombosis and Haemostasis   8 ( 1 )   102273   2024.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi.org/10.1016/j.rpth.2023.102273

  • Genetic and immunohistochemical profiling of NK/T-cell Lymphomas reveals prognostically relevant BCOR-MYC association Reviewed

    Naoki Oishi, Akira Satou, Masashi Miyaoka, Ichiro Kawashima, Takahiro Segawa, Kunio Miyake, Kunio Mochizuki, Keita Kirito, Andrew L. Feldman, Naoya Nakamura, and Tetsuo Kondo

    Blood Advances   2023.1( ISSN：2473-9529 )

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  • Evolution of snow algae, from cosmopolitans to endemics, revealed by DNA analysis of ancient ice Reviewed Major achievement

    Takahiro Segawa, Takahiro Yonezawa, Ryo Matsuzaki, Hiroshi Mori, Ayumi Akiyoshi, Francisco Navarro, Koji Fujita, Vladimir B. Aizen, Zhongqin Li, Shuhei Mano & Nozomu Takeuchi

    ISME Journal   2023.1( ISSN：1751-7362 )

    　More details

    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

  • Application of a high-throughput quantitative PCR system for simultaneous monitoring of SARS-CoV-2 variants and other pathogenic viruses in wastewater Reviewed

    Bikash Malla, Ocean Thakali, Sadhan Shrestha, Takahiro Segawa, Masaaki Kitajima, Eiji Haramoto

    SCIENCE OF THE TOTAL ENVIRONMENT   2022.12( ISSN：0048-9697 )

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  • Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy Reviewed

    Youichi Shinozaki, Alex Leung, Kazuhiko Namekata, Sei Saitoh, Huy Bang Nguyen, Akiko Takeda, Yosuke Danjo, Yosuke M. Morizawa, Eiji Shigetomi, Fumikazu Sano,Nozomu Yoshioka, Hirohide Takebayashi, Nobuhiko Ohno, Takahiro Segawa, Kunio Miyake, Kenji Kashiwagi, Takayuki Harada, Shin-ichi Ohnuma, Schuichi Koizumi

    Science Advances   2022.11( ISSN：2375-2548 )

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  • Paleogenomics reveals independent and hybrid origins of two morphologically distinct wolf lineages endemic to Japan Reviewed Major achievement

    Takahiro Segawa, Takahiro Yonezawa, Hiroshi Mori, Ayako Kohno, Yuichiro Kudo, Ayumi Akiyoshi, Jiaqi Wu, Fuyuki Tokanai, Minoru Sakamoto, Naoki Kohno, Hidenori Nishihara

    CURRENT BIOLOGY   2022.6( ISSN：0960-9822 )

    　More details

    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

▼display all

Presentations

  • 地球外生命探査にむけた永久凍土の微生物学的解析

    第１３回宇宙における生命ワークショップ  2025.2 

    　More details

    Language：Japanese   Presentation type：Oral presentation(general)  

  • メタゲノムデータから紐解く氷河微生物生態系のダイナミクス

    村上匠、瀬川高弘、大沼友貴彦、薄羽珠ノ介、河合繁、広瀬侑、竹内望、本郷　裕一

    ゲノム微生物学会  2024.3 

    　More details

    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation(general)  

  • 氷河微生物群集「クリオコナイト」の形成過程をメタゲノムデータから解き明かす

    村上　匠、瀬川　高弘、森　宙史、本郷　裕一、竹内望

    ゲノム微生物学会  2024.3 

    　More details

    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation(general)  

  • 東南極の海鳥における抗生物質耐性遺伝子の伝播

    瀬川高弘、高橋晃周、國分亙彦、石井聡

    微生物生態学会  2023.11 

    　More details

    Event date： 2023.11

    Language：Japanese   Presentation type：Oral presentation(general)  

    Venue：アクトシティ浜松  

  • Prevalence of antibiotic resistance genes in East Antarctic seabirds International conference

    Takahiro Segawa, Akinori Takahashi, Nobuo Kokubun,Satoshi Ishii

    The 14th Symposium on Polar Science  2023.11 

    　More details

    Event date： 2023.11

    Language：English   Presentation type：Oral presentation(invited, special)  

  • Early Detection of SARS-CoV-2 and its Variants Through Long-Term Monitoring of Wastewater by qPCR and Next-Generation Sequencing Techniques International conference

    Bikash MALLA, Niva STHAPIT, Made Sandhyana ANGGA, Sunayana RAYA, Aulia Fajar RAHMANI, Soichiro HIRAI, Annisa Andarini RUTI, Sadhana SHRESTHA, Takahiro SEGAWA, Eiji HARAMOTO

    Water and Environment Technology Conference  2023.7 

    　More details

    Event date： 2023.7

    Language：English   Presentation type：Oral presentation(general)  

  • Microbial source tracking for detection of fecal contamination of soil and river water samples in Japan by high-throughput quantitative PCR

    Sunayana Raya, Bikash Malla, Made Sandhyana Angga, Hien Hamabata, Kyota Yoshida, Takahiro Segawa, Hisashi Matsubayashi, and Eiji Haramoto

    21st International Symposium on Health-Related Water Microbiology  2023.7 

    　More details

    Event date： 2023.7

    Language：English   Presentation type：Oral presentation(general)  

▼display all

Awards

  • 研究特別奨励賞

    2023.9   山梨大学  

Teaching Experience (On-campus)

  • Practice in Life Sciences

    2025Year

  • Experimental Medicine and Bioinformatics

    2024Year

  • Practice in Life Sciences

    2024Year

  • Practice in Life Sciences

    2023Year

Social Activities

  • ウィズコロナの新技術開発

    日本下水道新聞  2022.10

  • ニホンオオカミ、大陸から来た2系統が交雑し誕生 山梨大など解明

    Role(s)： Media coverage

    JST「サイエンスポータル」  JST「サイエンスポータル」  2022.5

  • ニホンオオカミ　日本で誕生

    Role(s)： Media coverage

    NHKおはよう日本  2022.5

  • ニホンオオカミ　日本で誕生

    Yahooニュース（トップ）, MSNニュース、 gooニュース、共同通信、産経新聞、東京新聞、中日新聞、北陸中日新聞、神戸新聞、西日本新聞、山梨日日新聞、秋田魁新聞、岩手新聞、埼玉新聞、伊勢新聞、四国新聞、長崎新聞、熊本新聞、南日本新聞、毎日新聞、朝日新聞  2022.5

Media Coverage

  • ニホンオオカミはどこへ消えたのか？ イヌの来た道、ニホンオオカミがたどる道 Newspaper, magazine

    山と渓谷  2025.3

  • 薬剤耐性菌　地球的脅威に Newspaper, magazine

    毎日新聞  2024.7

  • 南極の生物に絶滅リスク Newspaper, magazine

    日本経済新聞  2024.6

    　More details

    Author：Myself