Associate Professor, Research Institute for Microbial Diseases, Osaka University

2000.8

Senior Researcher, National Institute of Infectious Diseases

2000.4

Researcher, National Institute of Infectious Diseases

1999.3

Research Fellow (JSPS), The Walter and Eliza Hall Institute of Medical Research (Melbourne, Australi

1997.3

Researcher, National Institute of Health

1993.4

Research Resident (Humana Science), National Institute of Health.

1992.4

Research Follow, JPSP

1991.4

Establishment of monoclonal antibodies broadly neutralize infection of hepatitis B virus Reviewed

Zhang H, Itoh Y, Suzuki T, Ihara KI, Tanaka T, Haga S, Enatsu H, Yumiya M, Kimura M, Takada A, Itoh D, Shibazaki Y, Nakao S, Yoshio S, Miyakawa K, Miyamoto Y, Sasaki H, Kajita T, Sugiyama M, Mizokami M, Tachibana T, Ryo A, Moriishi K, Miyoshi E, Kanto T, Okamoto T, Matsuura Y.

MICROBIOLOGY AND IMMUNOLOGY   66 ( 4 )   179 - 192   2022.4( ISSN：0385-5600 )

Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening.   Reviewed Major achievement

Tanaka, T. Saito, A. Suzuki, T. Miyamoto, Y. Takayama, K. Okamoto, T. Moriishi , K.

ANTIVIRAL RESEARCH   189   105268   2022.3( ISSN：0166-3542 )

Inhibitory effect of a novel thiazolidinedione derivative on hepatitis B virus entry Reviewed Major achievement

Tanaka, T. Okuyama-Dobashi, K. Motohashi, R. Yokoe, H. Takahashi, K. Wiriyasermkul, P. Kasai, H. Yamashita, A. Maekawa, S. Enomoto, N. Ryo, A. Nagamori, S. Tsubuki, M. Moriishi, K.

ANTIVIRAL RESEARCH   194   105165 - 105165   2021.8( ISSN：0166-3542 )

Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure

Honda, T. Yamada, N. Murayama, A. Shiina, M. Aly, H. H. Kato, A. Ito, T. Ishizu, Y. Kuzuya, T. Ishigami, M. Murakami, Y. Tanaka, T. Moriishi, K. Nishitsuji, H. Shimotohno, K. Ishikawa, T. Fujishiro, M. Muramatsu, M. Wakita, T. Kato, T.

Cellular and Molecular Gastroenterology and Hepatology   12 ( 5 )   1583 - 1598   2021.8( ISSN：2352-345X )

DsRNA Sequencing for RNA Virus Surveillance Using Human Clinical Samples Reviewed

Izumi, T. Morioka, Y. Urayama, S. I. Motooka, D. Tamura, T. Kawagishi, T. Kanai, Y. Kobayashi, T. Ono, C. Morinaga, A. Tomiyama, T. Iseda, N. Kosai, Y. Inokuchi, S. Nakamura, S. Tanaka, T. Moriishi, K. Kariwa, H. Yoshizumi, T. Mori, M. Matsuura, Y. Fukuhara, T.

PLoS One   13 ( 7 )   1310   2021.7( ISSN：1932-6203 )

Hepatitis C virus modulates signal peptide peptidase to alter host protein processing Reviewed

Hirano J, Yoshio S, Sakai Y, Songling L, Suzuki T, Itoh Y, Zhang H, Chen DV, Haga S, Oomori H, Kodama T, Maeda Y, Ono Y, Takahashi Y, Standley DM, Yamamoto M, Moriishi K, Moriya K, Kanto T, Takehara T, Koike K, Matsuura Y, Okamoto T

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   118 ( 22 )   e2026184118   2021.6( ISSN：0027-8424 )

Establishment of a Cell Culture Model Permissive for Infection by Hepatitis B and C Viruses. Reviewed Major achievement

Otoguro T, Tanaka T, Kasai H, Kobayashi N, Yamashita A, Fukuhara T, Ryo A, Fukai M, Taketomi A, Matsuura Y, Moriishi K

Hepatology Communications   5 ( 4 )   634 - 649   2021.4( ISSN：2471-254X )

Induction of HOX genes by HCV infection via impairment of histone H2A monoubiquitination. Reviewed Major achievement

Kasai H, Mochizuki K, Tanaka T, Yamashita A, Matsuura Y, Moriishi K

JOURNAL OF VIROLOGY   95 ( 6 )   e01784-20 - e01784-20   2021.2( ISSN：0022-538X )

N-Terminal PreS1 Sequence Regulates Efficient Infection of Cell-Culture-Generated Hepatitis B Virus Reviewed Major achievement

Asako Murayama , Norie Yamada , Yoshiki Osaki , Masaaki Shiina , Hussein Hassan Aly , Masashi Iwamoto, Senko Tsukuda, Koichi Watashi , Mami Matsuda , Ryosuke Suzuki , Tomohisa Tanaka , Kohji Moriishi, Tetsuro Suzuki, Hironori Nishitsuji, Masaya Sugiyama , Masashi Mizokami , Kunitada Shimotohno , Takaji Wakita , Masamichi Muramatsu , T Jake Liang , Takanobu Kato

HEPATOLOGY   73 ( 2 )   520 - 532   2021.2( ISSN：0270-9139 )

Deep Sequencing Analysis of Serum Hepatitis B Virus-RNA During Nucleot (side Analogue Therapy Reviewed

Matsuda, S. Maekawa, S. Komiyama, Y. Nakakuki, N. Muraoka, M. Suzuki, Y. Sato, M. Tatsumi, A. Miura, M. Amemiya, F. Shindo, H. Takano, S. Fukasawa, M. Yamaguchi, T. Nakayama, Y. Inoue, T. Sato, T. Yamashita, A. Moriishi, K. Enomoto, N.

HEPATOLOGY RESEARCH   51 ( 1 )   39 - 50   2021.1( ISSN：1386-6346 )

Identification of Two Critical Neutralizing Epitopes in the Receptor Binding Domain of Hepatitis B Virus preS1 Reviewed

Yato, K. Onodera, T. Matsuda, M. Moriyama, S. Fujimoto, A. Watashi, K. Aizaki, H. Tanaka, T. Moriishi, K. Nishitsuji, H. Shimotohno, K. Tamura, K. Takahashi, Y. Wakita, T. Muramatsu, M. Kato, T. Suzuki, R.

JOURNAL OF VIROLOGY   95 ( 5 )   e01680-20   2020.12( ISSN：0022-538X )

Establishment of a novel hepatitis B virus culture system using immortalized human hepatocytes.

Akahori Y, Kato H, Fujita T, Moriishi K, Tanaka Y, Watashi K, Imamura M, Chayama K, Wakita T, Hijikata M

Scientific Reports   10   21718 - 21718   2020.12( ISSN：2045-2322 )

Cancer-related genetic changes in multistep hepatocarcinogenesis and their correlation with imaging and histological findings Reviewed

Muraoka, M. Maekawa, S. Suzuki, Y. Sato, M. Tatsumi, A. Matsuda, S. Miura, M. Nakakuki, N. Shindo, H. Amemiya, F. Takano, S. Fukasawa, M. Nakayama, Y. Yamaguchi, T. Inoue, T. Sato, T. Yamashita, A. Moriishi, K. Matsuda, M. Enomoto, N.

HEPATOLOGY RESEARCH   50 ( 9 )   1071 - 1081   2020.9( ISSN：1386-6346 )

Anti-Viral Effects of Interferon-λ3 on Hepatitis B Virus Infection in Cell Culture Reviewed

N. Yamada, A. Murayama, M. Shiina, H. H. Aly, M. Iwamoto, S. Tsukuda, K. Watashi, T. Tanaka, K. Moriishi, H. Nishitsuji, M. Sugiyama, M. Mizukami, K. Shimotohno, M. Muramatsu, K. Murata, T. Kato

HEPATOLOGY RESEARCH   50 ( 3 )   283 - 291   2020.3( ISSN：1386-6346 )

C-terminal alpha Domain of p63 Binds to p300 to Coactivate beta-Catenin Reviewed

Katoh I, Maehata Y, Moriishi K, Hata RI, Kurata SI:

NEOPLASIA   21 ( 5 )   494 - 503   2019.3( ISSN：1476-5586 )

Hepatitis B virus (HBV)-infected patients with low hepatitis B surface antigen and HBV preS deletion mapping using deep sequencing demonstrates a unique association with viral markers Reviewed

PLoS One   14   e0212559   2019.2( ISSN：1932-6203 )

Potential Risk of Virus Carryover by Fabrics of Personal Protective Gowns. Reviewed

Katoh I, Tanabe F, Kasai H, Moriishi K, Shimasaki N, Shinohara K, Uchida Y, Koshiba T, Arakawa S, Morimoto M

Frontiers in Public Health   7   121   2019.1( ISSN：2296-2565 )

USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation. Reviewed

Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, He Z, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T, Matsuura Y.

JOURNAL OF VIROLOGY   93 ( 6 )   e01708-18   2019.1( ISSN：0022-538X )

HBV patients with low HBsAg and high HBcrAg titers have a high risk of HBV-related HCC. Reviewed

Suzuki, Y. Maekawa, S. Komatsu, N. Sato, M. Tatsumi, A. Miura, M. Matsuda, S. Muraoka, M. Nakakuki, N. Shindo, H. Amemiya, F. Takano, S. Fukasawa, M. Nakayama, Y. Yamaguchi, T. Inoue, T. Sato, T. Sakamoto, M. Yamashita, A. Moriishi, K., Enomoto, N.

HEPATOLOGY RESEARCH   49 ( 1 )   51 - 63   2018.10( ISSN：1386-6346 )

Roles of the 5' untranslated region of non-primate hepacivirus in translation initiation and viral replication. Reviewed Major achievement

Tanaka T, Otoguro T, Yamashita A, Kasai H, Fukuhara T, Matsuura Y, Moriishi K

JOURNAL OF VIROLOGY   92 ( 7 )   e01997-17   2018.4( ISSN：0022-538X )

Seroepidemiology of non-primate hepacivirus (NPHV) in Japanese native horses Reviewed

Shizuka HAYASHI, Tomohisa TANAKA, Kohji MORIISHI, Kazuhiro HIRAYAMA, Akio YAMADA, Kozue HOTTA

JOURNAL OF VETERINARY MEDICAL SCIENCE   80 ( 1 )   186 - 189   2018.2( ISSN：0916-7250 )

Characterization of SPP inhibitors suppressing propagation of HCV and protozoa Reviewed

Hirano, J., Okamoto, T., Sugiyama, Y., Suzuki, T., Kusakabe, S., Tokunaga, M., Fukuhara, T., Sasai, M., Tougan, T., Matsunaga, Y., Yamashita, K., Sakai, Y., Yamamoto, M., Horii, T., Standley, D. M., Moriishi, K., Moriya, K., Koike, K., Matsuura, Y.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   114 ( 50 )   E10782 - E10791   2017.12( ISSN：0027-8424 )

Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase Reviewed

Schaefer, B. Moriishi, K. Behrends, S.

PLoS One   12 ( 11 )   e0188344   2017.11( ISSN：1932-6203 )

The potential of signal peptide peptidase as a therapeutic target for hepatitis C Invited Reviewed Major achievement

Moriishi, K.

Expert Opinion on Therapeutic Targets   21 ( 9 )   827 - 836   2017.8( ISSN：1472-8222 )

Inhibitory effects of metachromin A on hepatitis B virus production via impairment of the viral promoter activity Reviewed Major achievement

Yamashita, A. Tamaki, M. Kasai, H. Tanaka, T. Otoguro, T. Ryo, A. Maekawa, S. Enomoto, N. de Voogd, N. J. Tanaka, J. Moriishi, K.

ANTIVIRAL RESEARCH   145   136 - 145   2017.8( ISSN：0166-3542 )

Cinnamic acid derivatives inhibit hepatitis C virus replication via the induction of oxidative stress Reviewed Major achievement

Amano, R. Yamashita, A. Kasai, H. Hori, T. Miyasato, S. Saito, S. Yokoe, H. Takahashi, K. Tanaka, T. Otoguro, T. Maekawa, S. Enomoto, N. Tsubuki, M. Moriishi, K.

ANTIVIRAL RESEARCH   145   123 - 130   2017.8( ISSN：0166-3542 )

Hepatitis B virus prevents excessive viral production via reduction of cell-death inducing DFF45-like effectors Reviewed Major achievement

Jun Yasumoto, Hirotake Kasai, Kentaro Yoshimura, Teruhime Otoguro, Koichi Watashi, Takaji Wakita, Atsuya Yamashita, Tomohisa Tanaka, Sen Takeda and Kohji Moriishi

JOURNAL OF GENERAL VIROLOGY   98 ( 7 )   1762 - 1773   2017.8( ISSN：0022-1317 )

Immunological function of Langerhans cells in HIV infection. Reviewed

Matsuzawa T, Ogawa Y, Moriishi K, Shimada S, Kawamura T.

JOURNAL OF DERMATOLOGICAL SCIENCE   87 ( 2 )   159 - 167   2017.8( ISSN：0923-1811 )

Inhibitory effect of presenilin inhibitor LY411575 on maturation of hepatitis C virus core protein, production of the viral particle and expressions of host proteins involved in pathogenicity Reviewed Major achievement

MICROBIOLOGY AND IMMUNOLOGY   60 ( 11 )   740 - 753   2016.10( ISSN：0385-5600 )

Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation Reviewed Major achievement

Tanaka, T.,Okuyama-Dobashi, K.,Murakami, S.,Chen, W.,Okamoto, T.,Ueda, K.,Hosoya, T.,Matsuura, Y.,Ryo, A.,Tanaka, Y.,Hagiwara, M.,Moriishi, K.

ANTIVIRAL RESEARCH   133   156 - 164   2016.9( ISSN：0166-3542 )

The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity Reviewed Major achievement

Aoki, R.,Kawamura, T.,Goshima, F.,Ogawa, Y.,Nakae, S.,Moriishi, K.,Nakao, A.,Shimada, S.

JOURNAL OF INVESTIGATIVE DERMATOLOGY   136 ( 6 )   1290 - 1292   2016.6( ISSN：0022-202X )

TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis. Reviewed Major achievement

Aizawa S, ,Okamoto T, ,Sugiyama Y, ,Kouwaki T, ,Ito A, ,Suzuki T, ,Ono C, ,Fukuhara T, Yamamoto M, ,Okochi M, ,Hiraga N, ,Imamura M, ,Chayama K, ,Suzuki R, ,Shoji I, ,Moriishi K, ,Moriya K, ,Koike K, ,Matsuura Y.

Nature Communications   4 ( 7 )   11379   2016.5( ISSN：2041-1723 )

Repression of Wnt/β-catenin response elements by p63 (TP63) Reviewed

Katoh I, ,Fukunishi N, ,Fujimuro M, ,Kasai H, ,Moriishi K, ,Hata R, ,Kurata S

CELL CYCLE   15 ( 5 )   699 - 710   2016.3( ISSN：1538-4101 )

Hepatocyte factor JMJD5 regulates HBV replication through interaction with HBx Reviewed Major achievement

Kouwaki T, ,Okamoto T, ,Ito A, ,Sugiyama Y, ,Yamashita K, ,Suzuki T, Kusakabe S, ,Hirano J, ,Fukuhara T, ,Yamashita A, ,Saito K, ,Okuzaki D, ,Watashi K, ,Sugiyama M, ,Yoshio S, ,Standley DM, ,Kanto T, ,Mizokami M, ,Moriishi K, ,Matsuura Y

JOURNAL OF VIROLOGY   90 ( 7 )   3530 - 3542   2016.1( ISSN：0022-538X )

Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide. Reviewed Major achievement

Okuyama-Dobashi K, ,Kasai H, ,Tanaka T, Yamashita A, Yasumoto J, ,Chen W, Okamoto T, Maekawa S, ,Watashi K, ,Wakita T, ,Ryo A, ,Suzuki T, ,Matsuura Y, ,Enomoto N, ,Moriishi K.

Scientific Reports   5   17047   2015.11( ISSN：2045-2322 )

Involvement of FKBP6 in hepatitis C virus replication Reviewed Major achievement

Kasai H, ,Kawakami K, ,Yokoe H, ,Yoshimura K, ,Matsuda M, ,Yasumoto J, ,Maekawa S, ,Yamashita A, ,Tanaka T, ,Ikeda M, ,Kato N, ,Okamoto T, ,Matsuura Y, ,Sakamoto N, ,Enomoto N, ,Takeda S, ,Fujii H, ,Tsubuki M, ,Kusunoki M, ,Moriishi K.

Scientific Reports   5   16699   2015.11( ISSN：2045-2322 )

Identification of Antiviral Agents Targeting Hepatitis B Virus Promoter from Extracts of Indonesian Marine Organisms by a Novel Cell-Based Screening Assay Reviewed Major achievement

Yamashita A, ,Fujimoto Y, ,Tamaki M, ,Setiawan A, ,Tanaka T, ,Okuyama-Dobashi K, ,Kasai H, ,Watashi K, ,Wakita T, ,Toyama M, ,Baba M, ,de Voogd NJ, ,Maekawa S, ,Enomoto N, ,Tanaka J, ,Moriishi K

Marine Drugs   13   6759 - 6773   2015.10( ISSN：1660-3397 )

Novel sex-dependent differentially methylated regions are demethylated in adult male mouse livers. Reviewed Major achievement

Ito, S., Hirabayashi, K., Moriishi, K., Matsui, Y., Moriya, K., Koike, K., Matsuura, Y., Shiota, K., Yagi, S.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   462 ( 4 )   332 - 338   2015.7( ISSN：0006-291X )

Deep sequencing and phylogenetic analysis of variants resistant to interferon-based protease inhibitor therapy in chronic hepatitis induced by genotype 1b hepatitis C virus. Reviewed Major achievement

Sato M, ,Maekawa S, ,Komatsu N, ,Tatsumi A, 他15名

JOURNAL OF VIROLOGY   89 ( 11 )   6105 - 6016   2015.6( ISSN：0022-538X )

Maternal restraint stress during pregnancy in mice induces 11β-HSD1-associated metabolic changes in the livers of the offspring. Reviewed Major achievement

J Dev Orig Health Dis   6 ( 2 )   105 - 114   2015.4

Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase Reviewed Major achievement

Int J Mol Sci   16   18439 - 18453   2015.2

Long-term imipramine treatment increases N-methyl-d-aspartate receptor activity and expression via epigenetic mechanisms. Reviewed Major achievement

Nghia NA,Takae HIRASAWA,Hirotake KASAI,Obata C,Kohji MORIISHI,Mochizuki K,Schuichi KOIZUMI,Takeo KUBOTA

EUROPEAN JOURNAL OF PHARMACOLOGY   in press   2015.2( ISSN：0014-2999 )

Hallmarks of hepatitis C virus in equine hepacivirus. Reviewed Major achievement

Tanaka T, ,Kasai H, ,Yamashita A, ,Okuyama-Dobashi K, ,Yasumoto J, ,Maekawa S, ,Enomoto N, ,Okamoto T, ,Matsuura Y, ,Morimatsu M, ,Manabe N, ,Ochiai K, ,Yamashita K, ,Moriishi K.

JOURNAL OF VIROLOGY   88 ( 22 )   13352 - 13366   2014.11( ISSN：0022-538X )

EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium. Reviewed Major achievement

J Invest Dermatol   134 ( 4 )   1158   2014.4

PBDE: structure-activity studies for the inhibition of hepatitis C virus NS3 helicase. Reviewed

Molecules   19 ( 4 )   4006   2014.4

Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge. Reviewed

Mar Drugs   12 ( 1 )   462 - 476   2014.1

Binding of HSV-1 Glycoprotein K (gK) to Signal Peptide Peptidase (SPP) Is Required for Virus Infectivity Reviewed Major achievement

PLoS One   9 ( 1 )   e8536 - e8536   2014.1( ISSN：1932-6203 )

Deep-Sequencing Analysis of the Association between the Quasispecies Nature of the Hepatitis C Virus Core Region and Disease Progression Reviewed Major achievement

J Virol   87 ( 23 )   12541 - 12551   2013.12

Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis C virus Reviewed Major achievement

PLoS One   8 ( 12 )   e8229   2013.12( ISSN：1932-6203 )

Mast Cells Play a Key Role in Host Defence against Herpes Simplex Virus Infection through TNF-α and IL-6 Production Reviewed Major achievement

Journal of Investigative Dermatology   133 ( 9 )   2170 - 2179   2013.9

Microglia Release ATP by Exocytosis Reviewed Major achievement

Glia   61   1320 - 1330   2013.8

Effects of immunization of pregnant guinea pigs with guinea pig cytomegalovirus glycoprotein B on viral spread in the placenta Reviewed Major achievement

Vaccine   31 ( 31 )   3199 - 3205   2013.6

Understanding the Biological Context of NS5A-Host Interactions in HCV Infection: A Network-Based Approach Reviewed Major achievement

J. Proteome Res.   12 ( 6 )   2537 - 2551   2013.6

IL-28B and IFN-alpha synergistically inhibit HCV replication Reviewed Major achievement

J Viral Hepatitis   2013.3

Ca(2+) /S100 proteins regulate HCV virus NS5A-FKBP8/FKBP38 interaction and HCV virus RNA replication. Reviewed Major achievement

Liver int   33 ( 7 )   1008 - 1018   2013.3

Antimicrobial Peptide LL-37 Produced by HSV-2-Infected Keratinocytes Enhances HIV Infection of Langerhans Cells Reviewed Major achievement

Cell Host & Microbe   13 ( 1 )   77 - 86   2013.1

Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp Reviewed Major achievement

PLOS One   7 ( 11 )   48635   2012.11

Upregulation of nuclear PA28γ expression in cirrhosis and hepatocellular carcinoma Reviewed Major achievement

Experimental and Therapeutic Medicine   3 ( 3 )   379 - 385   2012.9

Proteomic Analysis of Hepatitis C Virus (HCV) Core Protein Transfection and Host Regulator PA28gamma Knockout in HCV Pathogenesis: A Network-Based Study Reviewed Major achievement

J. Proteome Res.   11 ( 7 )   3664 - 3679   2012.6

Inhibition of hepatitis C virus NS3 helicase by manoalide. Reviewed Major achievement

J Nat Prod   75 ( 4 )   650 - 654   2012.4

Baculovirus GP64-mediated entry into mammalian cells Reviewed Major achievement

Journal of Virology   86 ( 5 )   2610 - 2620   2012.3

Inhibition of hepatitis C virus replication and NS3 helicase by the extract of the feather star Alloeocomatella polycladia Reviewed Major achievement

Marine Drugs   10 ( 4 )   744 - 761   2012.3

Exploitation of lipid components by viral and host proteins for hepatitis C virus infection Reviewed Major achievement

Frontiers in Microbiology   3   1 - 14   2012.2

Activation of the long terminal repeat of human endogenous retrovirus K by melanoma-specific transcription factor MITF-M1,2 Reviewed

Neoplasia   13 ( 11 )   1081 - 1092   2011.11

Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus Reviewed Major achievement

Journal of Virology   85 ( 24 )   13185 - 13194   2011.10

Heterogeneous nuclear ribonucleoprotein A2 participates in the replication of Japanese encephalitis virus through an interaction with viral proteins and RNA Reviewed Major achievement

Journal of Virology   85 ( 21 )   10976 - 10988   2011.8

Will there be an HCV meeting in 2020? summary of the 17th international meeting on hapatitis C virus and related viruses Reviewed Major achievement

Gestroenterology   141   e1 - e5   2011.5

HCVの病原性発現に関与する宿主因子とその機構 -Functions of host factors regarding HCV pathogenicity- Major achievement

森石　恆司

日本臨床   69 ( 4 )   103 - 108   2011.5

Involvement of cyclophilin B in the replication of Japanese encephalitis virus Reviewed Major achievement

Virology   412   211 - 219   2011.2

Elimination of hepatitis C virus from hepatogytes by a selective activation oftherapeutic molecules Reviewed Major achievement

PLos ONE   6 ( 1 )   15967   2011.1

Induction of ΔNp63 by the newly identified keratinocyte-specific transforming growth factor βsignaling pathway with smad2 and IkB kinase α in squamous cell carcinoma1,2 Reviewed

NEOPLASIA   12 ( 12 )   969 - 979   2010.12( ISSN：1522-8002 )

Network based analysis of hepatitis C virus core and NS4B protein interactions Reviewed Major achievement

Molecular BioSystems   6   2539 - 2553   2010.10

Peripheral B cells may serve as a reservoir for persistent hepatitis C virus infection Reviewed Major achievement

Journal of Innate immunity   2   607 - 617   2010.8

Peripheral B cells may serve as a reservoir for persistent hepatitis C virus infection. Reviewed Major achievement

J Innate Immun.   2 ( 6 )   607 - 6017   2010.8

Involvement of PA28gamma in the propagation of hepatitis C virus. Reviewed Major achievement

Hepatology   52 ( 2 )   411 - 420   2010.8

Acquisition of complement resistance through incorporation of CD44/Decay-accelerating factor into viral particles bearing baculovirus GP64 Reviewed Major achievement

Journal of Virology   84 ( 7 )   3210 - 3219   2010.4

Establishment of an indicator cell system for hepatitis C virus. Reviewed Major achievement

Microbiol Immunol   54 ( 4 )   206 - 220   2010.4

Involvement of PA28γ in the propagation of hepatitis C virus Reviewed Major achievement

Hepatology   52 ( 2 )   411 - 420   2010.3

Establishment of an indicator cell system for hepatitis C virus Reviewed Major achievement

Yoshinori TANAKA,Yoshio MORI,Hideki TANI,Takayuki ABE,Kohji MORIISHI,Hirotatsu KOJIMA,Tetsuo NAGANO,Takayoshi OKABE,Tetsuro SUZUKI,Masashi TATSUMI,Yoshiharu MATSUURA

Microbiology and Immunology   54   206 - 220   2010.1

Involvement of ceramide in the propagation of Japanese encephalitis virus Reviewed Major achievement

84 ( 6 )   2798 - 2807   2010.1

Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: analysis using mouse model and cultured cells. Reviewed Major achievement

175   1515   2009.10

Baculovirus Induces Type I Interferon Production through Toll-Like Receptor-Dependent and -Independent Pathways in a Cell-Type-Specific Manner Reviewed Major achievement

Abe, T.,Kaname, Y.,Wen, X. Y.,Tani, H.,Moriishi, K.,Uematsu, S.,Takeuchi, O.,Ishii, K. J.,Kawai, T.,Akira, S.,Matsuura, Y.

Journal of Virology   83 ( 16 )   7640   2009.8

Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway. Reviewed Major achievement

Taguwa S, Kambara H, Omori H, Tani H, Abe T, その他5名

Journal of Virology   83   10427   2009.8

Biological and immunological characteristics of hepatitis E virus-like particles based on the crystal structure Reviewed

Yamashita, T.,Mori, Y.,Miyazaki, N.,Cheng, R. H.,Yoshimura, M.,Unno, H.,Shima, R.,Moriishi, K.,Tsukihara, T.,Li, T. C.,Takeda, N.,Miyamura, T.,Matsuura, Y.

Proceedings of the National Academy of Sciences of the United States of America   106 ( 31 )   12986 - 12991   2009.2

Proteasomal Turnover of Hepatitis C Virus Core Protein Is Regulated by Two Distinct Mechanisms: a Ubiquitin-Dependent Mechanism and a Ubiquitin-Independent but PA28 gamma-Dependent Mechanism Reviewed Major achievement

Journal of Virology   83 ( 5 )   2389 - 2392   2009.2

Human VAP-C Negatively Regulates Hepatitis C Virus Propagation Reviewed Major achievement

Journal of Virology   83 ( 16 )   7959 - 7969   2009.2

Evaluation systems for anti-HCV drugs Reviewed Major achievement

Moriishi, K.,Matsuura, Y

Advanced Drug Delivery Reviews   59 ( 12 )   1213 - 1221   2007.2

Host factors involved in the replication of hepatitis C virus Reviewed Major achievement

Reviews in Medical Virology   17 ( 5 )   343 - 354   2007.2

Critical role of PA28 gamma in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis Reviewed Major achievement

Proceedings of the National Academy of Sciences of the United States of America   104 ( 5 )   1661 - 1666   2007.1

Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90 Reviewed Major achievement

EMBO Journal   25 ( 20 )   5015 - 5025   2006.10

Mechanisms of hepatitis C virus infection Reviewed Major achievement

Moriishi, K.,Matsuura, Y.

Antiviral Chemistry & Chemotherapy   14 ( 6 )   285 - 297   2002.2

Induction of Bad-mediated apoptosis by Sindbis virus infection: Involvement of pro-survival members of the Bcl-2 family Reviewed

Virology   292 ( 2 )   258 - 271   2002.2

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1 Reviewed Major achievement

Proceedings of the National Academy of Sciences of the United States of America   96 ( 17 )   9683 - 9688   1999.2

Mosaic structures of neurotoxins produced from Clostridium botulinum types C and D organisms Reviewed Major achievement

Moriishi, K.,Koura, M.,Abe, N.,Fujii, N.,Fujinaga, Y.,Inoue, K.,Ogumad, K.

Biochimica Et Biophysica Acta-Gene Structure and Expression   1307 ( 2 )   123 - 126   1996.6

Expression of listeriolysin O by intracellular Listeria monocytogenes following infection of lipopolysaccharide-treated or untreated J774.1 macrophage-like cells Reviewed Major achievement

Moriishi, K.,Koura, M.,Amano, F.

FEMS Immunology and Medical Microbiology   16 ( 3 )   213 - 222   1996.2

Molecular cloning of the gene encoding the mosaic neurotoxin: Composed of parts of botulinum neurotoxin types C1 and D, and PCR detection of this gene from Clostridium botulinum type C organisms Reviewed Major achievement

Moriishi, K.,Koura, M.,Fujii, N.,Fujinaga, Y.,Inoue, K.,Syuto, B.,Oguma, K.

Applied and Environmental Microbiology   62 ( 2 )   662 - 667   1996.2

Two Different Types of Adp-Ribosyltransferase C3 from Clostridium-Botulinum Type D Lysogenized Organisms Reviewed Major achievement

Moriishi, K.,Syuto, B.,Saito, M.,Oguma, K.,Fujii, N.,Abe, N.,Naiki, M.

Infection and Immunity   61 ( 12 )   5309 - 5314   1993.2

Purification and Characterization of Adp-Ribosyltransferases (Exoenzyme-C3) of Clostridium-Botulinum Type-C and Type-D Strains Reviewed Major achievement

Moriishi, K.,Syuto, B.,Yokosawa, N.,Oguma, K.,Saito, M.

Journal of Bacteriology   173 ( 19 )   6025 - 6029   1991.2

Separation of Toxic Activity and Adp-Ribosylation Activity of Botulinum Neurotoxin-D Reviewed Major achievement

Moriishi, K.,Syuto, B.,Oguma, K.,Saito, M.

Journal of Biological Chemistry   265 ( 27 )   16614 - 16616   1990.2

Molecular Diversity of Neurotoxins from Clostridium-Botulinum Type-D Strains Reviewed Major achievement

Moriishi, K.,Syuto, B.,Kubo, S.,Oguma, K.

Infection and Immunity   57 ( 9 )   2886 - 2891   1989.2

新型コロナウイルスによる血小板血栓形成メカニズムの解明

佐々木知幸、白井俊光、築地長治、大石沙織、横森良平、髙野勝弘、森石恆司、井上克枝

第45回日本血栓止血学会学術集会  2023.6  日本血栓止血学会

HBV Enhancer I-X promoterを標的にした抗ウイルス剤の同定とその抑制機序

山下篤哉、葛西宏威、田中智久、大津直樹、赤池康範、森石恆司

第69回日本ウイルス学会総会  2022.11  日本ウイルス学会

ラットヘパシウイルスのマウス適応化と肝脂肪蓄積への影響

大津直樹、田中智久、山下篤哉、葛西宏威、赤池康範、森石恆司

第69回日本ウイルス学会総会  2022.11  日本ウイルス学会

ラットヘパシウイルス感染細胞モデルの開発

田中智久、大津直樹、赤池康範、葛西宏威、山下篤哉、森石恆司

第69回日本ウイルス学会総会  2022.11  日本ウイルス学会

HCV感染によるポリコーム抑制複合体１活性制御に対するアセチル化反応の意義

葛西宏威、山下篤哉、田中智久、赤池康範、大津直樹、森石恆司

第69回日本ウイルス学会総会  2022.11  日本ウイルス学会

HBV/HCV共感染の病態悪化に関与する宿主因子の探索

赤池康範、田中智久、大津直樹、山下篤哉、葛西宏威、森石恆司

第69回日本ウイルス学会総会  2022.11  日本ウイルス学会

Analysis of the functional interaction between rodent hepacivirus and miR-122 International conference Major achievement

Tomohisa Tanaka, Naoki Ohtsu, Kohji Moriishi

28th international symposium on Hepatitis C virus, Flaviviruses, and related viruses  2022.7 

HBV・HCV共感染in vitroシステムの構築と感染による宿主遺伝子発現への影響 ：新規抗HBV戦略を目指した基盤研究 Invited Major achievement

森石恆司

広島肝臓セミナー  2022.4  ギリアド

B型およびC型肝炎ウイルスの感染培養細胞系の開発 Invited Major achievement

森石恆司

令和3年度「感染・免疫・がん・炎症」全国共同研究拠点シンポジウム  2022.3  北海道大学遺伝子病制御研究所

Regulatory mechanism of polycomb suppressive complex 1 activity by HCV infection

2021.11 

Cross-species transmission of rat hepacivirus and its adaptation to mouse.

2021.11 

Identification of antiviral agents targeting HBV Enhancer I-X promoter

2021.11 

Transient and stable replicon systems of SARS-CoV-2 for drug screening

2021.11 

HCV infection impairs monoubiquitination of histone H2A via proteolysis of RNF2 and activates expression of HOX genes International conference

Hirotake Kasai1, Kazuki Mochizuki2, Tomohisa Tanaka1, Atsuya Yamashita1, Yoshiharu Matsuura3, and Kohji Moriishi

19th Awaji International Forum on Infection and Immunity  2021.9 

Establishment of HepG2-derived cell line that permits HBV and HCV coinfection International conference

Tomohisa Tanaka, Teruhime Otoguro, Takasuke Fukuhara, Moto Fukai, Akinobu Taketomi, Yoshiharu Matsuura, Kohji Moriishi

27th International meeting on hepatitis C virus and related viruses  2021.7 

Establishment of a novel cell culture model permissive for infection by hepatitis B and C viruses Invited

Kohji Moriishi

Advanced Seminar Series on Microbiology and Immunology  2021.7 

B型肝炎ウイルス受容体結合領域に対する感染中和抗体の作製とエピトープ解析

矢藤慶悟、小野寺大志、松田麻未、藤本陽、渡士幸一、相崎英樹、加藤孝宣、森石恆司、田村浩二、高橋宜聖、脇田隆字、村松正道、鈴木亮介

第42回　日本分子生物学会総会  2019.12 

4,4'-bis(cyclohexylmethyl)biphenyl-2,2',5,5'-tetraol is the novel anti-HBV compound targeting the viral core promoter

Atsuya Yamashita, Tomohisa Tanaka, Teruhime Otoguro, Hirotake Kasai, and Kohji Moriishi

67th Annual meeting of the Japanese Society for Virology  2019.10 

Establishment of the cell line permissive for HBV and HCV coinfection

Teruhime Otoguro, Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Takasuke Fukuhara, Yoshiharu Matsuura and Kohji Moriishi

67th Annual meeting of the Japanese Society for Virology  2019.10 

Induction of HOX genes by HCV infection via a reduction in histone H2A monoubiquitination International conference

Hirotake Kasai, Kohji Moriishi

26th International symposium on hepatitis C virus and related viruses  2019.10 

Characterization of monoclonal antibodies against hepatitis B virus preS1 region from antigen-specific memory B cells International conference

Keigo Yato1, 2, Taishi Onodera3, Mami Matsuda1, Akira Fujimoto4, Koichi Watashi1, Hideki Aizaki1, Takanobu Kato1, Kohji Moriishi5, Koji Tamura2, Yoshimasa Takahashi3, Takaji Wakita1, Masamichi Muramatsu1, Ryosuke Suzuki1,

2019 International HBV Meeting  2019.10 

Involvement of a novel cyclin-dependent kinase in HBV infection International conference

Tomohisa Tanaka, Kohji Moriishi

2019 International HBV Meeting  2019.10 

B型およびC型肝炎ウイルスに近縁なウイルスとその由来 Invited

森石恆司

日本ウイルス学会　札幌支部会  2019.7 

Inhibition of signal peptide peptidase restores monoubiquitination of histone H2A and impairs Hox gene expression in HCV-infected cells.

Hirotake Kasai1, Tomohisa Tanaka1, Atsuya Yamashita1, Teruhime Otoguro1 and Kohji Moriishi1

66th Annual meeting of the Japanese Society for Virology  2018.10 

Identification of Hepacivirus F subspecies from Japanese rodents

Tomohisa Tanaka, Teruhime Otoguro, Hirotake Kasai, Atsuya Yamashita, Hiroaki Kariwa, and Kohji Moriishi

66th Annual meeting of the Japanese Society for Virology  2018.10 

Functional Characterization of hepacivirus replication Invited International conference

Kohji Moriishi

2018 USA-Japan hepatitis panel meeting  2018.10 

Identification of hepacivirus F subspecies in Japan International conference

Tomohisa Tanaka, Hiroaki Kariwa, Kohji Moriishi

25th International symposium on hepatitis C virus and related viruses  2018.10 

Identification of a cyclin-dependent kinase that facilitates HBV infection International conference

Tomohisa Tanaka, Teruhime Otoguro, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi

2018 International HBV Meeting  2018.10 

BerberineのHBV増殖抑制活性とその抑制機序の解明

山下篤哉、田中智久、葛西宏威、乙黒光姫、梁明秀、 前川伸哉、榎本信幸、森石恆司

第28回抗ウイルス療法学会  2018.6 

Functional Characterization of Hepacivirus Replication Invited International conference Major achievement

Kohji Moriishi

International Symposium. BIOMARKERS FOR PERSONALIZED HEPATOLOGY  2018.5 

1. The bidirectional interplay of hepatitis B virus and cell-death inducing DFF45-like effectors

Hirotake Kasai, Jun Yasumoto, Atsuya Yamashita, Tomohisa Tanaka, Koichi Watashi, Takaji Wakita, Teruhime Otoguro, Kohji Moriishi

65th Annual Meeting of the Japanese Society for Virology  2017.10 

Establishment of hepatitis B and C virus co-infection cell line

Teruhime Otoguro, Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi

65th Annual Meeting of the Japanese Society for Virology  2017.10 

Inhibitory effects of metachromin A on hepatitis B virus production via impairment of the viral promoter activity

Atsuya Yamashita, Tomohisa Tanaka, Teruhime Otoguro, Hirotake Kasai, Kohji Moriishi

65th Annual Meeting of the Japanese Society for Virology  2017.10 

5’-terminal stem-loop of equine hepacivirus RNA permits miR-122-independent replication Major achievement

Tomohisa Takana, Teruhime Otoguro, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi

65th Annual Meeting of the Japanese Society for Virology  2017.10 

Screening of antiviral compounds using a highly HBV-permissible HpeG2 cell line International conference Major achievement

Tomohisa Tanaka, Teruhime Otoguro, Wenjia Chen, Hirotake Kasai, Atsuya Yamashita, Kohji Moriishi

2017　International meeting on Molecular Biology of Hepatitis B virus  2017.9 

Involvement of cell death inducing DFF45-like effectors in hepatitis B virus replication International conference

Kohji Moriishi, Jun Yasumoto, Hirotake Kasai, Teruhime Otoguro, Atsuya Yamashita, Tomohisa Tanaka

2017　International meeting on Molecular Biology of Hepatitis B virus  2017.9 

Cross-species compatibility of hepacivirus 5’ untranslated region International conference

Tanaka T, Otoguro T, Kasai H, Yamashita A, Okuyama-Dobashi K, Moriishi K

第64回日本ウイルス学会総会  2016.10 

Hepatitis C virus infection impairs mono-ubiquitination of histone H2A and activates expression of homeobox genes.

Hepatitis C virus infection impairs mono-ubiquitination of histone H2A and activates expression of homeobox genes.

第64回日本ウイルス学会総会  2016.10 

Establishment of highly HBV-permissible HepG2 cell line to facilitate screening of antiviral compounds

Otoguro T, Tanaka T, Chen W, Kasai H, Yamashita A, Okuyama-Dobashi K, Moriishi K,

2016.10 

CDK9 inhibitor FIT-039 suppresses HBV propagation.

2016.10 

Anti-HBV activity of Coptidis rhizome alkaloids via targeting the viral core promoter.

Yamashita A, Tanaka T, Okuyama-Dobashi K, Kasai H, Moriishi K

Japanese Society for Virology  2016.10 

Functional homology of hepacivirus 5’ UTRs in IRES activity and replication. International conference

Tanaka T, Otoguro T, Kasai H, Yamashita A, Okuyama-Dobashi K, Moriishi K

23rd International symposium on hepatitis C virus and related viruses  2016.10 

Inhibition of HBV propagation by treatment with CDK9 inhibitor FIT-039 International conference

Tanaka T, Okuyama-Dobashi K, Chen W, Okamoto T, Ueda K, Hosaya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M and Kohji Moriishi

2016 Internationa HBV meeting  2016.9 

Metachromin A, sesquiterpene from marine sponge Dactylospongia metachromia, exerts anti-HBV activity via inhibition of HBV core promoter. Major achievement

第63回日本ウイルス学会学術集会  2015.11 

プレセニリン阻害剤のC型肝炎ウイルス増殖抑制効果の検討 Major achievement

第63回日本ウイルス学会学術集会  2015.11 

Hepatitis B virus infection impairs lipid droplet growth via host regulatory proteins Major achievement

The 2015 Italy-Japan Liver Workshop: Steato-Hepatitis and Hepatocellular Carcinoma  2015.10 

Establishment of a novel cell line with high susceptibility to NTCP-dependent HBV infection Major achievement

The 2nd Japan-Italy Liver Workshop:“Hepatitis, Steatosis and Hepatocellular Carcinoma: Molecular Basis and Clinical Links  2014.11 

トリプシン・EDTAによるNTCP依存HBV感染の増強

圡橋香織,葛西宏威,田中智久,森石恆司,他

第62回日本ウイルス学会学術集会  2014.11 

海洋生物抽出物ライブラリーソースからのB型肝炎ウイルス転写活性抑制化合物の探索

山下篤哉,藤本雄介,田中智久,葛西宏威,森石恆司,他

第62回日本ウイルス学会学術集会  2014.11 

EFdA,a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium Major achievement

DC 2014 13th international symposium  2014.9 

Infection of equine hepacivirus in a closed colony of Japanese native horse

The 21st International meeting on Hepatitis C virus and related viruses  2014.9 

Establishment of a novel cell line with high susceptibility to NTCP-dependent HBV infection.

2014 International Meeting on Molecular Biology of Hepatitis B viruses  2014.9 

CCR5阻害薬Maraviroc内服による表皮内ランゲルハンス細胞のHIV-1感染性への影響 Major achievement

川村　龍吉,松澤　高光,小川　陽一,青木　類,森石　恆司,小柳　義夫,潟永　博之,島田　眞路

第24回抗ウイルス療法研究会  2014.5 

EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium Major achievement

LC2013 13th International Workshop on Langerhans Cells  2013.10 

Caffeic acid phenethyl esterとその類縁化合物によるHCVゲノム複製阻害効果の検討　

山下篤哉,沈暉,葛西宏威,藤本雄介,森石恆司

第６０回日本ウイルス学会学術集会  2012.11 

新規宿主因子FKBP6によるHCV複製制御機構の解析 Major achievement

葛西宏威,河上國洋,平田有佳理,山下篤哉,池田正徳,加藤宣之,岡本徹,松浦善治,楠木正己,森石恆司　

第６０回日本ウイルス学会学術集会  2012.11 

海綿動物Amphimedon sp. 抽出画分によるHCVNS3プロテアーゼ・ヘリカーゼ活性阻害の解析 Major achievement

藤本雄介,山下篤哉,池田正徳,加藤宣之,森石恆司

第６０回日本ウイルス学会学術集会  2012.11 

FKBP6 plays an important role in HCV replication through binding to HCV NS5A. Major achievement

19th International Symposium on Hepatitis C virus and related viruses.  2012.10 

IL-28B(IFNλ-3)and IFN-αsynergistically inhibit HCV replication Major achievement

Hiroko SHINDOH,Shinya MAEKAWA,Nobutoshi KOMATSU,Kazuki KOMASE,Mika MIURA,Makoto KADOKURA,Ryota SUEKI,Fumitake Amemiya,Yasuhiro NAKAYAMA,Taisuke INOUE,Minoru SAKAMOTO,Atsuya YAMASHITA,Kohji MORIISHI,Nobuyuki ENOMOTO

第3回国際交流フォーラム  2012.4 

ウイルス感染による細胞内SUMO化修飾の動態解析 Major achievement

芦沢　暁,森石　恆司,藤室　雅弘

第34回日本分子生物学会  2011.12 

Regulation of HCV replication by FKBP8-dependent or -independent Hsp90 activity Major achievement

Kunihiro KAWAKAMI,Hirotake KASAI,Atsuya YAMASHITA,Yoshiharu MATSUURA,Masami KUSUNOKI,Kohji MORIISHI

第34回日本分子生物学会  2011.12 

Baculovirus GP64-mediated entry into mamalian cells Major achievement

Chikako KATAOKA,Hideki TANI,Yuuki KANAME,Shuhei TAGUWA,Hiroyuki ABE,Takasuke FUKUHARA,Kohji MORIISHI,Yoshiharu MATSUURA

第34回日本分子生物学会  2011.12 

Involvement of cyclophilin B in the replication of Japanese encephalitis virus Major achievement

Hiroto KAMBARA,Hideki TANI,Yoshio MORI,Takayuki ABE,Hiroshi KATOH,Takasuke FUKUHARA,Shuhei TAGUWA,Kohji MORIISHI,Yoshiharu MATSUURA

International Union of Microbiological Societies 2011 Congress  2011.9 

Marine natural products as a source of the novel antiviral agent targeting to HCV NS3 helicase Major achievement

Atsuya YAMASHITA,Yuusuke FUJIMOTO,Kohji MORIISHI

International Union of Microbiological Societies 2011 Congress  2011.9 

Inhibitory effect of marine natural products on the replication of hepatitis C virus Major achievement

Yuusuke FUJIMOTO,Atsuya YAMASHITA,Kohji MORIISHI

International Union of Microbiological Societies 2011 Congress  2011.9 

Regulation of HCV replication by FKBP8-dependent or -independent Hsp90 activity Major achievement

Kunihiro KAWAKAMI,Hirotake KASAI,Atsuya YAMASHITA,Nobuyuki ENOMOTO,Yoshiharu MATSUURA,Masami KUSUNOKI,Kohji MORIISHI

18th International Symposium on Hepatitis C Virus and Related Viruses  2011.9 

海洋生物抽出物より取得したcholestrol slfateによるC型肝炎ウイルスNS3 helicase阻害作用 Major achievement

古田　篤史,Kazi Abdus SALAM,長浜　夏樹,秋光　信佳,田中　淳一,谷　英典,山下　篤哉,森石　恆司,常田　聡,関口　勇地,野田　尚宏

第63回日本生物工学会大会  2011.9 

Inhibitors against NS3 helicase of hepatitis C virus from coral reef invertebrates Major achievement

Junichi TANAKA,Natsuki NAGAHAMA,Atsushi FURUTA,Kazi Abdus SALAM,Nobuyoshi AKIMITSU,Hidenori TANI,Atsuya YAMASHITA,Kohji MORIISHI,Satoshi TSUNEDA,Yuji Sekiguchi,Naohiro NODA

52nd Annual American Society of Pharmacognosy meeting  2011.8 

Identification and biochemical characterization of novel hepatitis C virus NS3 inhibitors, Manoalide and Psammaplin A Major achievement

Kazi Abdus SALAM,Atsushi FURUTA,Natsuki NAGAHAMA,Junichi TANAKA,Atsuya YAMASHITA,Hidenori TANI,Yuji SEKIGUCHI,Satoshi TSUNEDA,Kohji MORIISHI,Kenichi IJIRI,Naohiro NODA,Nobuyoshi AKIMITSU

16th Annual Meeting of the RNA Society  2011.6 

In silico分子設計手法によるHCV NS3 protease活性阻害化合物の創製 Major achievement

山下　篤哉,松本　武久,高谷　大輔,上條　加寿恵,前川　伸哉,坂本　直哉,池田　正徳,加藤　宣之,梅山　秀明,横山　茂之,榎本　信幸,森石　恆司

第21回抗ウイルス療法研究会  2011.5 

海洋生物をライブラリーソースとしたHCV NS3 Helicase活性阻害化合物の検索 Major achievement

山下　篤哉,古田　篤史,田中　淳一,長浜　夏樹,秋光　信佳,Kazi Abdus SALAM,谷　英典,松田　泰嘉,藤田　統,藤本　雄介,池田　正徳,加藤　宣之,前川　伸哉,榎本　信幸,常田　聡,関口　勇地,野田　尚宏,森石　恆司

第21回抗ウイルス療法研究会  2011.5 

C型肝炎ウイルス感染細胞特異的なウイルス排除システムの構築 Major achievement

温　暁玉,阿部　隆之,久木原　博,田鍬　修平,森　嘉生,谷　英樹,加藤　宣之,鈴木　哲朗,巽　正志,森石　恆司,松浦　喜治

第58回日本ウイルス学会学術集会  2010.11 

HCVによる脂質代謝障害の分子機序 Major achievement

森石　恆司,松浦　喜治

第58回日本ウイルス学会学術集会  2010.11 

バキュロウイルスベクターの遺伝子導入に伴う宿主自然免疫応答の解析 Major achievement

二宮　彰紀,温　暁玉,要　祐喜,谷　英樹,森石　恆司,阿部　隆之,松浦　喜治

第58回日本ウイルス学会学術集会  2010.11 

C型肝炎ウイルスの細胞侵入におけるフォスフォリパーゼCおよびプロテインキナーゼC依存的なシグナル伝達経路の関与 Major achievement

谷　英樹,阿部　隆之,森石　恆司,松浦　喜治

第58回日本ウイルス学会学術集会  2010.11 

C型肝炎ウイルスはオートファジーを誘導して持続感染を成立させる Major achievement

寒原　裕登,田鍬　修平,藤田　尚信,野田　健司,森石　恆司,吉森　保,松浦　喜治

第58回日本ウイルス学会学術集会  2010.11 

核小体蛋白質B23はC型肝炎ウイルスの複製を抑制する Major achievement

加藤　大志,森　嘉生,寒原　裕登,要　祐喜,谷　英樹,阿部　隆之,神谷　亘,森石　恆司,松浦　喜治

第58回日本ウイルス学会学術集会  2010.11 

不死化ヒト肝細胞株であるHc細胞に対する患者血清由来HCVの持続感染システム Major achievement

塩川　舞,福原　崇介,後藤　志典,二宮　彰紀,谷　英樹,阿部　隆之,森石　恆司,松浦　喜治

第58回日本ウイルス学会学術集会  2010.11 

A splice variant of CD44 participates in the IP-10 production in cells infected with HCV Major achievement

Takayuki ABE,Kohji MORIISHI,Yoshiharu MATSUURA

17th International Meeting on Hepatitis C Virus and Related Viruses  2010.9 

Inhibition of autophagy induces lysosomal vacuolation in cells replicating HCV Major achievement

Hiroto KAMBARA,Shuhei TAGUWA,Naonobu FUJITA,Takeshi NODA,Tamotsu YOSHIMORI,Kohji MORIISHI,Yoshiharu MATSUURA

17th International Meeting on Hepatitis C Virus and Related Viruses  2010.9 

HCV replication enhances secretion of an immature cathepsin B through induction of an incomplete autophagy Major achievement

Shuhei TAGUWA,Hiroto KAMBARA,Naonobu FUJITA,Takeshi NODA,Tamotsu YOSHIMORI,Kohji MORIISHI,Yoshiharu MATSUURA

17th International Meeting on Hepatitis C Virus and Related Viruses  2010.9 

Involvement of PA28gamma in the propagation of HCV Major achievement

Kohji MORIISHI,Ikuo SHOJI,Yoshio MORI,Ryosuke SUZUKI,Tetsuro SUZUKI,Chikako KATAOKA,Yoshiharu MATSUURA

17th International Meeting on Hepatitis C Virus and Related Viruses  2010.9 

Involvement of phospholipatse C and protein kinase C-dependent signaling pathways in the entry of HCV Major achievement

Hideki TANI,Takayuki ABE,Kohji MORIISHI,Yoshiharu MATSUURA

17th international Meeting on Hepatitis C Virus and Related Viruses  2010.9 

Intracellular delivery of serum-derived HCV Major achievement

Takasuke FUKUHARA,Hideki TANI,Mai SHIOKAWA,Takayuki ABE,Kohji MORIISHI,Akinobu TAKETOMI,Yoshihiko MAEHARA,Yoshiharu MATSUURA

17th Intrnational Meeting on Hepatitis C Virus and Related Viruses  2010.9 

Advanced Course of Liver Patho logy Major achievement

2023Year

Life Science II (Basic Medical Sciences: Host Defense and Pathological Regulation) Major achievement

2023Year

統合臨床医学コース5

2023Year

統合臨床医学コース4

2023Year

統合臨床医学コース2

2023Year

統合臨床医学コース1

2023Year

感染制御学

2021Year  Type of subject：Professional education (undergraduate)

新総合医学概論

2017Year

チュートリアルコース3

2017Year  Type of subject：Professional education (undergraduate)

チュートリアルコース2

2017Year

チュートリアルコース8

2017Year  Type of subject：Professional education (undergraduate)

環境健康科学

2017Year  Type of subject：Other (undergraduate)

微生物学（二年） Major achievement

2017Year  Type of subject：Professional education (undergraduate)

生命科学特論II（病態制御学）

2017Year  Type of subject：Master's (Graduate School)

チュートリアルコース7

2017Year  Type of subject：Professional education (undergraduate)

チュートリアルコース５

2017Year  Type of subject：Professional education (undergraduate)

Microbiology Major achievement

2017Year  Type of subject：Professional education (undergraduate)

微生物学総論、細菌学、ウイルス学、真菌学

日本ウイルス学会   理事  

2017.4 - 2019.3   

日本ウイルス学会   理事  

2016.4 - 2017.3   

日本ウイルス学会   評議委員  

2016.4 - 2017.3