Identification of an Essential Cytoplasmic Region of Interleukin-7 Receptor α Subunit in B-Cell Development. Reviewed Major achievement

Kasai H, Kuwabara T, Matsui Y, Nakajima K, Kondo M.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   2018.8( ISSN：1422-0067 )

Roles of the 5' Untranslated Region of Nonprimate Hepacivirus in Translation Initiation and Viral Replication. Reviewed

Tanaka T, Otoguro T, Yamashita A, Kasai H, Fukuhara T, Matsuura Y, Moriishi K.

JOURNAL OF VIROLOGY   2018.3( ISSN：0022-538X )

Inhibitory effects of metachromin A on hepatitis B virus production via impairment of the viral promoter activity. Reviewed

Yamashita A, Tamaki M, Kasai H, Tanaka T, Otoguro T, Ryo A, Maekawa S, Enomoto N, de Voogd NJ, Tanaka J, Moriishi K.

ANTIVIRAL RESEARCH   2017.9( ISSN：0166-3542 )

Cinnamic acid derivatives inhibit hepatitis C virus replication via the induction of oxidative stress. Reviewed

Amano R, Yamashita A, Kasai H, Hori T, Miyasato S, Saito S, Yokoe H, Takahashi K, Tanaka T, Otoguro T, Maekawa S, Enomoto N, Tsubuki M, Moriishi K.

ANTIVIRAL RESEARCH   2017.9( ISSN：0166-3542 )

Hepatitis B virus prevents excessive viral production via reduction of cell-death inducing DFF45-like effectors. Reviewed Major achievement

Yasumoto J#, Kasai H#, Yoshimura K, Otoguro T, Watashi K, Wakita T, Yamashita A, Tanaka T, Takeda S and Moriishi K

JOURNAL OF GENERAL VIROLOGY   2017.7( ISSN：0022-1317 )

Acetylation Modulates IL-2 Receptor Signaling in T Cells. Reviewed Major achievement

Kuwabara T, Kasai H, Kondo M.

JOURNAL OF IMMUNOLOGY   2016.12( ISSN：0022-1767 )

2. Inhibitory effect of presenilin inhibitor LY411575 on maturation of hepatitis C virus core protein, production of the viral particle and expression of host proteins involved in pathogenicity. Reviewed

Otoguro T, Tanaka T, Kasai H, Yamashita A, Moriishi K.

MICROBIOLOGY AND IMMUNOLOGY   2016.11( ISSN：0385-5600 )

Repression of Wnt/β-catenin response elements by p63 (TP63). Reviewed

CELL CYCLE   2016.3( ISSN：1538-4101 )

Identification of Antiviral Agents Targeting Hepatitis B Virus Promoter from Extracts of Indonesian Marine Organisms by a Novel Cell-Based Screening Assay. Reviewed

Marine Drugs   2015.11( ISSN：1660-3397 )

Involvement of FKBP6 in hepatitis C virus replication Reviewed Major achievement

Scientific Reports   2015.11( ISSN：2045-2322 )

Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide. Reviewed Major achievement

Scientific Reports   2015.11( ISSN：2045-2322 )

Maternal restraint stress during pregnancy in mice induces 11β-HSD1-associated metabolic changes in the livers of the offspring. Reviewed

Journal of Developmental Origins of Health and Disease   6 ( 2 )   105 - 114   2015.4( ISSN：2040-1744 )

Long-term imipramine treatment increases N-methyl-d-aspartate receptor activity and expression via epigenetic mechanisms. Reviewed Major achievement

EUROPEAN JOURNAL OF PHARMACOLOGY   in press   2015.4( ISSN：0014-2999 )

Hallmarks of hepatitis C virus in equine hepacivirus. Reviewed

JOURNAL OF VIROLOGY   88 ( 22 )   13352 - 13366   2014.11( ISSN：0022-538X )

Enhanced diacylglycerol production by phospholipase D activation is responsible for abnormal increase in concanavalin A cap formation in polymorphonuclear leukocytes from Chediak-Higashi syndrome (beige) mice. Reviewed

INTERNATIONAL IMMUNOPHARMACOLOGY   21 ( 1 )   193 - 199   2014.7( ISSN：1567-5769 )

Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis C virus. Reviewed

PLoS One   8 ( 12 )   2013.12( ISSN：1932-6203 )

Microglia Release ATP by Exocytosis Reviewed Major achievement

GLIA   61   1320 - 1330   2013.8( ISSN：0894-1491 )

Novel heterogenous CHS1 mutations identified in five Japanese patients with Chediak-Higashi Syndrome Reviewed Major achievement

Fuminori TANABE,Hirotake KASAI,Michiko MORIMOTO,Shigeharu OH,Hidetoshi TAKADA,Toshiro HARA,Masahiko ITO

Case Reports in Medicine   2010   1 - 5   2010.11

Improvement of deficient natural killer acitivity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro Reviewed Major achievement

Fuminori TANABE,Hirotake KASAI,Limin HE,Tomohiro KIN,Takashi FUJIKADO,Toshihide KUMAMOTO,Toshio HARA,Tsutomu IWATA,Masahiko ITO

International Immunopharmacology   9   366 - 370   2009.1

IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression. Reviewed Major achievement

Kikuchi K, Kasai H, ,Watanabe A, Lai AY, Kondo M.

journal of immunology   181 ( 1 )   383 - 392   2008.7

Increase in the level of macrophage colony-stimulating factor in patients with systemic lupus erythmatosus Reviewed Major achievement

Pingting YANG,W.G. XIAO,L. J. ZHAO,J. LU,Limin HE,Hirotake KASAI,Masahiko ITO

Annals of the Rheumatic Diseases   67 ( 3 )   429 - 430   2008.3

Delayed cell cycle progression and apoptosis induced by hemicellulase-treated Agaricus blazei Reviewed Major achievement

Masaki KAWAMURA,Hirotake KASAI

eCAM   4 ( 1 )   83 - 94   2007.4

Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice Reviewed Major achievement

Michiko MORIMOTO,Fuminori TANABE,Hirotake KASAI,Masahiko ITO

NTERNATIONAL IMMUNOPHARMACOLOGY   7   973 - 980   2007.3

Delayed Cell Cycle Progression and Apoptosis Induced by Hemicellulase-Treated Agaricus blazei. Reviewed

Kawamura M, Kasai H.

Evid Based Complement Alternat Med.   4 ( 1 )   83 - 94   2007.3

Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis Reviewed Major achievement

Pingting YANG,Hirotake KASAI,W-G Xiao,L-J Zhao,Limin HE,Atsuya YAMASHITA,Xuewen DENG,Masahiko ITO

ANNALS OF THE RHEUMATIC DISEASES   65   1671 - 1672   2006.11

Predominance of Three NF-kappaB Binding Sites in the Long Terminal Repeat Region of HIV Type 1 Subtype C Isolates from Zambia. Reviewed Major achievement

Munkanta M,Handema R, Kasai H,Gondwe C,Deng X,Yamashita A, Asagi T,Yamamoto N,Ito M, Kasolo F,Terunuma H.

AIDS Res Hum Retroviruses.   21 ( 10 )   901 - 906   2005.10

Abstract Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells. Reviewed Major achievement

Kawamura M,Kasai H,He L,Deng X,Yamashita A,Terunuma H,Horiuchi I,Tanabe F,Ito M.

Immunology.   114 ( 3 )   397 - 409   2005.5

Predominance of 3 NF-κB binding sites in the long terminal repeat region of HIV-1 subtype C isolates from Zambia Reviewed Major achievement

M. MUNKANTA,R. HANDEMA,Hirotake KASAI,C. Gondwe,X. DENG,Atsuya YAMASHITA,T. ASAGI,N. YAMAMOTO,Masahiko ITO,F. KASOLO,H. TERUNUMA

AIDS RESEARCH AND HUMAN RETROVIRUSES   21   901 - 906   2005.4

Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells Reviewed Major achievement

Hirotake KASAI,Limin HE,Xuewen DENG,Atsuya YAMASHITA,Hiroshi TERUNUMA,Isao HORIUCHI,Fuminori TANABE,Masahiko ITO

IMMUNOLOGY   114   397 - 409   2005.3

Chediak-Higashi症候群発症メカニズムに関する検討 Major achievement

葛西　宏威,森本美智子,伊藤　正彦,田辺文憲

厚生労働科学研究費補助金難治性疾患克服研究事業原発性免疫不全症候群に関する調査研究平成16年度総括・分   85   2005.3

IL-12 Production Induced by Agaricus blazei Fraction H (ABH) Involves Toll-like Receptor (TLR). Reviewed Major achievement

Kasai H,He LM,Kawamura M,Yang PT,Deng XW,Munkanta M,Yamashita A,Terunuma H,Hirama M,Horiuchi ,Natori T,Koga T,Amano Y,Yamaguchi N,Ito M.,

Evid Based Complement Alternat Med.   1 ( 3 )   259 - 267   2004.12

Increased CCR4 expression on circulating CD4+ T cells in ankylosing spondylitis, rheumatoid arthritis and systemic lupus erythematosus Reviewed Major achievement

P. T. YANG,H. KASAI,L. J. ZHAO,W. G. XIAO,F. TANABE,M. ITO

CLINICAL AND EXPERIMENTAL IMMUNOLOGY   138   342 - 347   2004.8

Effects of 10-day confinement on the immune system and psychological aspects in humans Reviewed Major achievement

Tamiyasu SHIMAMIYA,Nobuyuki TERADA,Yoshimitsu HIEJIMA,Sonoe WAKABAYASHI,Hirotake KASAI,Motohiko MOHRI

JOURNAL OF APPLIED PHYSIOLOGY   97 ( 3 )   920 - 924   2004.5

Chediak-Higashi症候群患者における原因遺伝子CHS1の変異の検討 Major achievement

葛西　宏威,田辺　文憲,伊藤　正彦,上松　一永

厚生労働科学研究費補助金難治性疾患克服研究事業原発性免疫不全症候群に関する調査研究平成15年度総括・分   63 - 65   2004.3

Chediak-Higashi症候群における責任遺伝子の役割について Major achievement

伊藤　正彦,葛西　宏威

乳酸菌研究会に関する報告書   142 - 145   2003.12

Prevalence of drug-resistance-associated mutations in antiretroviral drug-naive Zambians infected with subtype C HIV-1 Reviewed Major achievement

Ray HANDEMA,Hiroshi TERUNUMA,Francis KASOLO,Hirotake KASAI,Moses SICHONE,Atsuya YAMASHITA,Xuewen DENG,Georgina MULUNDU,Koji ICHIYAMA,Mwansa MUNKANTA,Tomoyuki YOKOTA,Naomi WAKASUGI,Fu

AIDS RESEARCH AND HUMAN RETROVIRUSES   19 ( 2 )   151 - 160   2003.8

Emergence of new HIV-1 sybtypes other than subtype C among antenatal woman in Lusaka, Zambia Reviewed Major achievement

Ray HANDEMA,Hiroshi TERUNUMA,Francis KASOLO,Hirotake KASAI,Moses SICHONE,Georgina MULUNDU,Xuewen DENG,Koji ICHIYAMA,Satoshi MITARAI,Mitsuo HONDA,Naoki YAMAMOTO

AIDS RESEARCH AND HUMAN RETROVIRUSES   17 ( 8 )   759 - 763   2001.8

Glycyrrhizin enhances intereukin-12 production in peritoneal macrophages Reviewed Major achievement

Jihong DAI,Yasumasa IWATANI,Takaomi ISHIDA,Hiroshi TERUNUMA,Hirotake KASAI,Yoichiro IWAKULA,Hiromi FUJIWARA,Masahiko ITO

IMMUNOLOGY   103   235 - 243   2001.3

STAM2, a new member of the STAM family,binding to the Janus kinases Reviewed Major achievement

Kazuhiro ENDO,Toshikazu TAKESHITA,Hirotake KASAI,Yoshiteru SASAKI,Nobuyuki TANAKA,Hironobu ASAO,Kazu KIKUCHI,Mitsuhiro YAMADA,Min CHEN,John J O'SHEA,Kazuo SUGAMURA

FEBS LETTERS   477   55 - 61   2000.7

"Identification of antiviral agents targeting HBV Enhancer I-X promoter

2021.11 

"Transient and stable replicon systems of SARS-CoV-2 for drug screening

2021.11 

"Cross-species transmission of rat hepacivirus and its adaptation to mouse

2021.11 

"Regulatory mechanism of polycomb suppressive complex 1 activity by HCV infection

2021.11 

HBV　

2019.10 

Effect of hepatitis C virus infection on phospholipid composition in host cells.

2019.10 

HBV core promoter

2019.10 

HBV and HCV

2019.10 

Identification of Hepacivirus F subspecies from Japanese rodents

2018.10 

Inhibition of signal peptide peptidase restores monoubiquitination of histone H2A and Hox gene expression in HCV-infected cells Major achievement

2018.10 

Berberine suppresses hepatitis Bvirus production via impairment of HBV core promoter activity

2018.10 

5'-terminal stem-loop of equine hepacivirus RNA permits miR-122-independent replication.

2017.10 

Inhibitory effects of metachromin A on hepatitis B virus production via impairment of viral promoter activity.

2017.10 

The bidirectional interplay of hepatitis B virus and cell-death inducing DFF45-like effectors. Major achievement

Hirotake Kasai et al

2017.10 

Establishment of hepatitis B and C virus co-infection cell line.

2017.10 

ユビキチン制御システム関連分子PA28gammaは小脳プルキンエ細胞の神経機能を調整する Major achievement

第３９回日本分子生物学会年会  2016.12 

Hepatitis C virus infection impairs monoubiquination of histone H2A and activates expression of homeobox genes. Major achievement

2016.10 

Anti-HBV activity of Coptidis rhizome alkaloids via targeting the viral core promoter.

2016.10 

Cross-species compatibility of heapcivirus 5’ untranslated region

2016.10 

Establishment of highly HBV-permissible HepG2 cell line to facilitate screening of antiviral compounds.

2016.10 

Functional homology of heapcivirus 5’ UTRs in IRES activety and replication International conference

23rd International Symposium on Hepatitis C Virus and Related Viruses,  2016.10 

ミエリン形成におけるヘッジホッグシグナルの機能とシグナル活性調節機構の解明

2016.3 

海綿由来のセキステルペン系化合物metachromin AのB型肝炎ウイルスコアプロモーター抑制活性を介した抗ウイルス活性

2015.12 

Hepatitis B virus downregulates expression of CIDE-B and CIDE-C and impairs lipid droplet growth. Major achievement

2015.11 

Hepatitis B virus downregulates expression of CIDE-B and CIDE-C and impairs lipid droplet growth. Major achievement

2015.11 

ヘッジホッグシグナルはシュワン細胞のミエリン形成準備期における形態形成を特異的に調節する

2015.7 

HBV感染による細胞内脂肪滴形成への影響 Major achievement

2014.10 

Probe Electronspray Ionization 質量分析法（PESI-MS)を用いたHCV感染細胞内脂質組成の解析

葛西宏威,吉村健太郎,安本順,山下篤哉,竹田扇,森石恆司

第６１回日本ウイルス学会学術総会  2013.11  日本ウイルス学会

FKBP6 Plays Important Role in HCV ReplicationThrough Binding to HCV NS5A.

2012.12 

新規宿主因子FKBP6によるHCV複製制御機構 Major achievement

葛西　宏威,河上　國洋,平田　有佳理,山下　篤哉,池田　正徳,その他５名

2012.11  日本ウイルス学会

FKBP6 plays an important role in HCV replication through binding to HCV NS5A. Major achievement

2012.10 

Regulation of HCV replication by FKBP8-dependent or -independent Hsp90 activity Major achievement

Kunihiro KAWAKAMI,Hirotake KASAI,Atsuya YAMASHITA,Yoshiharu MATSUURA,Masami KUSUNOKI,Kohji MORIISHI

2011.12 

Regulation of HCV replication by FKBP8-dependent or -independent Hsp90 activity International conference Major achievement

Kunihiro KAWAKAMI,Hirotake KASAI,Atsuya YAMASHITA,Nobuyuki ENOMOTO,Yoshiharu MATSUURA,Masami KUSUNOKI,Kohji MORIISHI

18th International Symposium on Hepatitis C Virus and Related Viruses  2011.9 

HIV-1感染者由来CD4陽性T細胞株の産生する抗HIV-1液性因子 Major achievement

山下　篤哉,照沼　裕,トウ　学文,高嶋　能文,三間屋　純一,花房　秀次,岡　慎一,酒井　道生,白幡　聡,藤井　輝久,石川　正明,高橋　義博,池田　柊一,三浦　琢磨,松田　重三,田中　勇悦,葛西　宏威,加藤　伊陽子,山本　直樹,伊藤　正彦

第20回日本エイズ学会  2006.11 

HIV-1感染の病態進行に伴うNK細胞サブセットの変化についての検討 Major achievement

トウ　学文,照沼　裕,金　浩範,ムンカンタ　ムワンサ,Gondwe CLEMENT,山下　篤哉,葛西　宏威,河村　正輝,伊藤　正彦,花房　秀次,三浦　琢磨,三間屋　純一

第18回日本エイズ学会学術集会・総会  2004.12 

HIV-1感染長期未発症者における抗HIV-1液性因子の結果 Major achievement

山下　篤哉,照沼　裕,トウ　学文,ムンカンタ　ムワンサ,葛西　宏威,高嶋　能文,花房　秀次,岡　慎一,酒井　道生,白幡　聡,藤井　輝久,石川　正明,高橋　義博,池田　柊一,三浦　琢磨,田中　勇悦,山本　直樹,三間屋　純一,伊藤　正彦

第18回日本エイズ学会学術集会・総会  2004.12 

Chediak-Higashi症候群患者由来の責任遺伝子CHS1の変異に関する検討 Major achievement

葛西　宏威

平成16年度厚生労働省科学研究費第1回班会議  2004.11 

Chediak-Higashi症候群患者における責任遺伝子CHS1の突然変異 Major achievement

葛西　宏威

平成16年度中部乳酸菌研究会  2004.11 

Chediak-Higashi症候群患者由来の責任遺伝子CHS1の変異に関する検討 Major achievement

葛西　宏威

原発性免疫不全症候群調査研究班 平成15年度第1回班会議  2003.12 

HIV-1感染長期未発症者における抗HIV-1液性因子の検索 Major achievement

山下　篤哉,トウ　学文,ムンカンタ　ムワンサ,葛西　宏威,伊藤　正彦,照沼　裕,山本　直樹

第33回日本免疫学会総会・学術集会  2003.12 

エイズ長期未発症から発症にいたる際のウイルス産生動態 Major achievement

トウ　学文,照沼　裕,山下　篤哉,葛西　宏威,加藤　真吾,斉藤　有紀,小田原　史知,高嶋　能文,花房　秀次,酒井　道生,白幡　聡,藤井　輝久,石川　正明,岡　慎一,高橋　義博,池田　柊一,三浦　琢磨,松田　重三,伊藤　正彦,三間屋　純一

第17回日本エイズ学会学術集会・総会  2003.11 

HIV-1感染者由来のT細胞株樹立とその性状解析;抗HIV-1液性因子の解析を中心として Major achievement

山下　篤哉,トウ　学文,ムンカンタ　ムワンサ,葛西　宏威,山本　直樹,伊藤　正彦,照沼　裕

日本ウイルス学会第51回学術集会・総会  2003.10 

酵素処理アガリクス「ABPC]のIL12産生について Major achievement

葛西　宏威

第1回健康と環境の国際シンポジウム -キノコと免疫ー  2003.5  第1回健康と環境の国際シンポジウム -キノコと免疫ー

HTLV-1/II感染によりIL-2レセプターからのシグナル伝達が恒常的に起こるユニークなヒトT細胞株の解析ー第2報ー Major achievement

山下　篤哉,吉田　勉,高橋　良明,三浦　英靖,山岡　昇司,菅村　和夫,葛西　宏威,照沼　裕,伊藤　正彦,山本　直樹

第31回日本免疫学会総会・学術集会  2001.12 

日本人血友病患者におけるHIV-1感染及び発症関連遺伝子ーケモカインレセプターの遺伝子多型についての検討 Major achievement

トウ　学文,照沼　裕,ハンデマ　レイ,花房　秀次,瀧　正志,葛西　宏威,山下　篤哉,塩田　達雄,伊藤　正彦,三間屋　純一

第15回日本エイズ学会学術集会・総会  2001.11 

ザンビアにおけるHIV-1サブタイプCの薬剤耐性変異の遺伝子解析 Major achievement

ハンデマ　レイ,照沼　裕,Francis KASOLO,葛西　宏威,山下　篤哉,トウ　学文,ジョルジナムルンドゥ,市山　浩二,若杉　なおみ,本多　三男,山本　直樹,伊藤　正彦

第15回日本エイズ学会学術集会・総会  2001.11 

ザンビアのHIV-1の分子疫学的解析 Major achievement

ハンデマ　レイ,照沼　裕,Francis KASOLO,葛西　宏威,トウ　学文,山下　篤哉,本田　三男,山本　直樹,伊藤　正彦

第49回日本ウイルス学会学術集会・総会  2001.11 

HIV-1 subtyping in ZAMBIA Major achievement

ハンデマ　レイ,照沼　裕,Francis KASOLO,葛西　宏威,トウ　学文,山下　篤哉,山本　直樹,本多　三男,伊藤　正彦

第42回日本熱帯医学会大会  2001.9 

Emergence of new HIV-1 subtypes other than subtype C among antenatal women International conference Major achievement

Ray HANDEMA,Hiroshi TERUNUMA,F. KASOLO,Hirotake KASAI,S. MOSES,Naoki YAMAMOTO,Masahiko ITO

The 1st IAS conference on HIV pathogenesis and treatment  2001.7 

ザンビアでのHIV感染者と非感染者におけるTTウイルス(N22) の検出率の検討 Major achievement

トウ　学文,照沼　裕,葛西　宏威,ハンデマ　レイ,山本　直樹,伊藤　正彦

第14回日本エイズ学会学術集会・総会  2000.11 

Phylogeny of HIV-1 in Lusaka, Zambia Major achievement

Ray HANDEMA　　　　　,Hiroshi TERUNUMA,Hirotake KASAI,Xuewen DENG　　　　　,Naoki YAMAMOTO,Masahiko ITO

第14回日本エイズ学会学術集会・総会  2000.11 

HIV-1長期未発症者での宿主因子の検討ー特にケモカインレセプターの遺伝子多型を中心として Major achievement

照沼　裕,トウ　学文,ハンデマ　レイ,楊　栄閣,何　麗敏,三間屋　純一,花房　秀次,滝　正志,葛西　宏威,田代　眞人,伊藤　正彦

第14回日本エイズ学会学術集会・総会  2000.11 

ザンビアでのHIV-1感染無症候者におけるGlycyrrhizinの経口投与での効果の検討 Major achievement

照沼　裕,木村　一史,御手洗　聡,斎藤　玲子,葛西　宏威,ハンデマ　レイ,トウ　学文,高野　昇一,沼崎　義夫,山本　直樹,伊藤　正彦

第14回日本エイズ学会学術集会・総会  2000.11 

TTVとHIVの合併感染およびTTV検出における免疫状態についての検討 Major achievement

トウ　学文,照沼　裕,葛西　宏威,ハンデマ　レイ,伊藤　正彦

第48回日本ウイルス学会学術集会・総会  2000.10 

2015

Number of people receiving guidance ：1people 

Graduation / pass / number of people awarded degrees ：1people