Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine (Pharmacology) Assistant Professor
Title
Assistant Professor
Kozo Saito
Research History
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Interdisciplinary Graduate School of Medicine, University of Yamanashi Department of Neuropharmacology Assistant Professor
2019.7
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Kyoto Prefectural University of Medicine Department of Neurology, Kyoto Prefectural University of Medicine Research Associate
2017.4 - 2019.3
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University Hospital Kyoto Prefectural University of Medicine Department of Neurology Clinical Research Associate
2016.4 - 2017.3
Education
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Kyoto Prefectural University of Medicine Graduate School of Medical Science Neurology
2012.4 - 2016.3
Country： Japan
Course： Doctor course
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Kyoto Prefectural University of Medicine
2000.4 - 2006.3
Country： Japan
Degree
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博士（医学） ( 2018.3 京都府立医科大学 )
Research Projects
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一次性アストロサイト病「アレキサンダー病」におけるミクログリアの役割に関する研究
2022.4 - 2025.3
文部科学省／日本学術振興会 科学研究費助成事業 若手研究
Authorship：Principal investigator Type of fund：：Science research expense
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アストロサイト・ミクログリア機能イメージングによるアレキサンダー病 の分子病態解明
2021.7 - 2022.3
国立大学法人山梨大学 山梨大学 萌芽的融合研究プロジェクト
Authorship：Principal investigator
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アストロサイト・ミクログリア機能イメージングによるアレキサンダー病 の分子病態解明
2021.7 - 2022.3
山梨大学 萌芽的融合研究プロジェクト
Authorship：Principal investigator
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「先進ゲノム支援」（先進ゲノム解析研究推進プラットフォーム）支援課題採択
2020.12 - 2021.3
文部科学省 （科学研究費助成事業 新学術領域研究『学術研究支援基盤形成』）
齋藤光象
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アストロサイト・ニューロン・ミクログリア三者相互作用の病態解明によるアレキサンダー病治療開発戦略
2020.7 - 2021.3
山梨大学 萌芽的融合研究プロジェクト
Authorship：Principal investigator
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アストロサイト・ニューロン・ミクログリア三者相互作用の病態解明によるアレキサンダー病治療開発戦略
2020.7 - 2021.3
山梨大学 萌芽的融合研究プロジェクト
Authorship：Principal investigator
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難治性疾患モデルのニューロングリア動態のin vivoイメージング解析
2019.4 - 2022.3
文部科学省／日本学術振興会 科学研究費助成事業 若手研究
Authorship：Principal investigator Type of fund：：Science research expense
Papers
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Yen-Phung Le, Kozo Saito, Bijay Parajuli, Kent Sakai, Yuto Kubota, Miho Miyakawa, Youichi Shinozaki, Eiji Shigetomi, Schuichi Koizumi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 ( 24 ) 17597 - 17597 2023.12( ISSN：1661-6596 eISSN：1422-0067 )
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Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model Reviewed
Kozo Saito, Eiji Shigetomi, Youichi Shinozaki, Kenji Kobayashi, Bijay Parajuli, Yuto Kubota, Kent Sakai, Miho Miyakawa, Hiroshi Horiuchi, Junichi Nabekura, Schuichi Koizumi
BRAIN 147 ( 2 ) 698 - 716 2023.11( ISSN：0006-8950 eISSN：1460-2156 )
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A promising drug for neuropathic pain: identification of vesicular nucleotide transporter as a novel target of eicosapentaenoic acid. Reviewed
Kozo Saito, Schuichi Koizumi
Purinergic Signalling 2023.1( ISSN：1573-9538 )
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Ocular P2 receptors and glaucoma Reviewed
Youichi Shinozaki, Kozo Saito, Kenji Kashiwagi, Schuichi Koizumi
NEUROPHARMACOLOGY 222 109302 - 109302 2022.10( ISSN：0028-3908 )
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Yuji Tanaka, Takashi Ando, Kazuki Mochizuki, Satoshi Igarashi, Kyoichiro Tsuchiya, Kozo Saito, Yasumi Ito, Zentaro Yamagata, Masaru Iwasaki, YHAB Health Data Survey Group 2020
Frontiers in Aging 3 2022.10( ISSN：2673-6217 eISSN：2673-6217 )
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ミクログリアによる全身監視・制御システムの解明 Invited
齋藤光象、小泉修一
ファルマシア 58 ( 9 ) 853 - 857 2022.9( ISSN：0014-8601 )
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Abnormal Ca2+ Signals in Reactive Astrocytes as a Common Cause of Brain Diseases Invited Reviewed
Schuichi Koizumi, Eiji Shigetomi, Fumikazu Sano, Kozo Saito, Sun Kwang Kim, Junichi Nabekura
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021.12
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Adenosine A2B receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development Reviewed
Masayoshi Tanaka, Eiji Shigetomi, Bijay Parajuli, Hiroaki Nagatomo, Youichi Shinozaki, Yuri Hirayama, Kozo Saito, Yuto Kubota, Yosuke Danjo, Ji Hwan Lee, Sun Kwang Kim, Junichi Nabekura, Schuichi Koizumi
GLIA 2021.8( ISSN：0894-1491 )
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Alexander disease: diversity of cell population and interactions between neuron and glia Reviewed
Kozo Saito, Eiji Shigetomi, Schuichi Koizumi
Folia pharmacologica Japonica 2021.7( ISSN：1347-8397 )
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An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with TDP-43 proteinopathy, associated with Alzheimer's disease pathology Reviewed
So Tando, Takashi Kasai, Ikuko Mizuta, Hisashi Takahashi, Takeshi Yaoi, Kozo Saito, Tomohito Hojo, Toshiki Mizuno, Masato Hasegawa, Kyoko Itoh
NEUROPATHOLOGY 2021.6( ISSN：0919-6544 )
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Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus Invited Reviewed
Fumikazu Sano, Eiji Shigetomi, Youichi Shinozaki, Haruka Tsuzukiyama, Kozo Saito, Katsuhiko Mikoshiba, Hiroshi Horiuchi, Dennis Lawrence Cheung, Junichi Nabekura, Kanji Sugita, Masao Aihara, Schuichi Koizumi
JCI insight 2021.5
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A case of extensive epidural abscess concomitant with intracranial involvement due to Staphylococcus aureus successfully treated with ceftriaxone in combination with linezolid and rifampin Reviewed
Kozo Saito, Ryosuke Fukazawa, Shiori Ogura, Takashi Kasai, Toshiki Mizuno
e Neurological Sci 14 1 - 3 2019.3
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Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model Reviewed
Kozo Saito, Eiji Shigetomi, Rei Yasuda, Ryuichi Sato, Masakazu Nakano, Kei Tashiro, Kenji F. Tanaka, Kazuhiro Ikenaka, Katsuhiko Mikoshiba, Ikuko Mizuta, Tomokatsu Yoshida, Masanori Nakagawa, Toshiki Mizuno, Schuichi Koizumi
GLIA 66 ( 5 ) 1053 - 1067 2018.5( ISSN：0894-1491 )
Presentations
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アレキサンダー病におけるグリア細胞間コミュニケーション
厚生労働省科学研究費補助金 難治性疾患政策研究事業 「遺伝性白質疾患・知的障害をきたす疾患の診断・治療・研究システム構築班」 2023.12
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Microglia sense dysfunction of astrocytes by P2Y12 receptors and prevent disease progression of Alexander disease model mice.
2022.12
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The mechanisms of which microglia are related to the pathology in the “primary astrocytic disease" Alexander disease
The 96th Annual Meetings of the Japanese Pharmacological Society 2022.12 The Japanese Pharmacological Society
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Analysis of microglial function in “primary astrocyte disease” Alexander disease
2022.10
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Microglia Ca2+ signals in Alexander disease model
第95回日本薬理学会年会 2022.3
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Microglia Ca2+ signals in Alexander disease model
文部科学省科学研究費補助金 学術変革領域研究（A）「グリアデコーディング：脳-身体連関を規定するグリア情報の読み出しと理解」第３回班会議 2021.12
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Microglia Ca2+ signals in Alexander disease model
文部科学省科学研究費補助金 学術変革領域研究（A）「グリアデコーディング：脳-身体連関を規定するグリア情報の読み出しと理解」第２回班会議 2021.8
Awards
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平成30年度第29回青蓮賞
2019.3 京都府立医科大学
Teaching Experience (On-campus)
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統合臨床医学・チュートリアル講義
2023Year Type of subject：Professional education (undergraduate)
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薬理学
2023Year Type of subject：Professional education (undergraduate)
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薬理学
2021Year Type of subject：Professional education (undergraduate)
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薬理学
2020Year Type of subject：Professional education (undergraduate)
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薬理学
2019Year Type of subject：Professional education (undergraduate)
Guidance results
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2023
Type：Ph.D. dissertations guidance
Number of people receiving guidance ：1people (Overseas students)：1people
Graduation / pass / number of people awarded degrees ：1people (Overseas students)：1people
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2021
Type：Achievement of student guidance (graduate school)
Number of people receiving guidance ：2people