Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine (Biochemistry 2) Assistant Professor
Title
Assistant Professor
Takashi Yokoyama
Research History
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国立大学法人 奈良先端科学技術大学院大学 先端科学技術研究科 バイオサイエンス領域 腫瘍細胞生物学研究室 助教
2016.6 - 2020.3
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公益財団法人 がん研究会 がん研究所 発がん研究部 博士研究員
2008.4 - 2016.6
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千葉大学 大学院 理学部 特任研究員
2007.10 - 2008.3
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千葉大学大学院 理学部 学術研究支援員
2006.4 - 2007.9
Education
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千葉大学大学院 自然科学研究科 生命資源科学専攻
2002.4 - 2006.3
Country： Japan
Course： Doctor later
Degree
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博士（理学） ( 2007.3 千葉大学大学院 )
Research Projects
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TRIB1によるEMT関連遺伝子の転写活性化を介したがん転移促進機能の解明
2022.4 - 2024.3
独立行政法人 日本学術振興会 科学研究費補助金 基盤研究 (C)
横山 隆志
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TRIB1によるMAPキナーゼ経路とEMT関連遺伝子の転写活性化を介したがん進展メカニズムの解明
2021.11 - 2024.5
武田科学振興財団 医学系研究助成
横山 隆志
Authorship：Principal investigator Type of fund：：Donation
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がん特異的なROS除去機能の阻害による新規がん抵抗性の獲得
2018.4 - 2021.3
基盤研究（C）
横山 隆志
Authorship：Principal investigator Type of fund：：Science research expense
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活性酸素種の調節機能を標的としたがん予防・予測マウスモデルの作製と解析
2018.4 - 2019.3
公益財団法人 鈴木謙三記念医科学応用研究財団 調査研究助成
横山 隆志
Authorship：Principal investigator Type of fund：：Donation
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がん特異的な新規ROS調節機能を標的としたがん予防・がん予測法の開発
2018.4 - 2019.3
公益財団法人 奈良先端科学技術大学院大学支援財団 教育研究活動支援
Authorship：Principal investigator Type of fund：：Donation
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シグナル伝達と転写制御を結ぶ白血病原因遺伝子TRIB1の解析
2013.4 - 2016.3
基盤研究（C）
横山 隆志
Authorship：Principal investigator Type of fund：：Science research expense
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白血病発症におけるTribファミリータンパク質とTGFβ/Smadシグナル経路の相互作用の検討
2011.10 - 2012.3
新学術領域研究「がん支援」 総括支援活動班 若手共同研究支援
横山 隆志
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骨髄性白血病の発症と悪性化を規定する分子基盤の解明
2011.4 - 2014.3
基盤研究（A）
中村 卓郎
Authorship：Coinvestigator(s) Type of fund：：Science research expense
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Trib1/2ダブルノックアウトマウスを用いた造血幹細胞分化における機能解析
2011.4 - 2013.3
若手研究（B）
横山 隆志
Authorship：Principal investigator Type of fund：：Science research expense
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がんの進展におけるTribblesファミリー遺伝子を介したシグナル異常の役割
2011.4 - 2012.3
公益財団法人 武田科学振興財団 医学系研究奨励
横山 隆志
Authorship：Principal investigator Type of fund：：Donation
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Trib1による白血病発症機構の解明
2009.4 - 2011.3
若手研究（B）
横山 隆志
Authorship：Principal investigator Type of fund：：Science research expense
Papers
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The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation Reviewed Major achievement
Mitsuyoshi Motizuki, Takashi Yokoyama, Masao Saitoh, Keiji Miyazawa
Journal of Biological Chemistry 300 ( 1 ) 105580 - 105580 2024.1( ISSN：0021-9258 )
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Smad2Δexon3 and Smad3 have distinct properties in signal transmission leading to TGF-β-induced cell motility Reviewed
Takashi Yokoyama, Takahito Kuga, Yuka Itoh, Shigeo Otake, Chiho Omata, Masao Saitoh, Keiji Miyazawa
JOURNAL OF BIOLOGICAL CHEMISTRY 299 ( 2 ) 102820 - 102820 2022.12( ISSN：0021-9258 )
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BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes Reviewed
Yoshitaka Sunami, Takashi Yokoyama, Seiko Yoshino, Tomoko Takahara, Yukari Yamazaki, Hironori Harada, Takuro Nakamura
Blood Advances 2021.10( ISSN：2473-9529 )
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TGF-β–induced cell motility requires down-regulation of ARHGAPs to sustain Rac1 activity Reviewed
Mitsuyoshi Motizuki, Daizo Koinuma, Takashi Yokoyama, Yuka Itoh, Chiho Omata, Kohei Miyazono, Masao Saitoh and Keiji Miyazawa
JOURNAL OF BIOLOGICAL CHEMISTRY 2021.3( ISSN：0021-9258 )
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Group V secretory phospholipase A2 regulates endocytosis of acetylated LDL by transcriptional activation of PGK 1 in RAW264.7 macrophage cell line.
Daisuke Fujioka, Yosuke Watanabe, Takamitsu Nakamura, Takashi Yokoyama, Keiji Miyazawa, Makoto Murakami, Kiyotaka Kugiyama
Journal of Atherosclerosis and Thrombosis 2021.2( ISSN：1340-3478 )
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Trib1 promotes acute myeloid leukemia progression by modulating the transcriptional programs of Hoxa9. Reviewed
Seiko Yoshino, Takashi Yokoyama, Yoshitaka Sunami, Tomoko Takahara, Aya Nakamura,Yukari Yamazaki, Shuichi Tsutsumi, Hiroyuki Aburatani and Takuro Nakamura
Blood 2020.7( ISSN：0006-4971 )
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Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression. Reviewed
Ikuko Nakamae, Tsumoru Morimoto, Hiroki Shima, Masafumi Shionyu, Hisayo Fujiki, Noriko Yoneda-Kato, Takashi Yokoyama, Shigehiko Kanaya, Kiyomi Kakiuchi, Tsuyoshi Shirai, Edy Meiyanto, Jun-Ya Kato
MOLECULES 2019.11( ISSN：1420-3049 )
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Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence. Reviewed
Beni Lestari, Ikuko Nakamae, Noriko Yoneda-Kato, Tsumoru Morimoto, Shigehiko Kanaya, Takashi Yokoyama, Masafumi Shionyu, Tsuyoshi Shirai, Edy Meiyanto, and Jun-ya Kato
Scientific Reports 9 ( 1 ) 14867 2019.10( ISSN：2045-2322 )
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Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth. Reviewed
Yonika Arum Larasati, Noriko Yoneda-Kato, Ikuko Nakamae, Takashi Yokoyama, Edy Meiyanto, and Jun-ya Kato
Scientific Reports 8 ( 1 ) 2039 2018.2( ISSN：2045-2322 )
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Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia. Reviewed
Ikuko Nakamae, Jun-ya Kato, Takashi Yokoyama, Hidenori Ito and Noriko Yoneda-kato
Blood advances 1 ( 20 ) 1682 - 1693 2017.9
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Transactivation of Sytl1/Slp1 by Meis1 promotes CXCL12/CXCR4 signaling and leukemogenesis. Reviewed
Takashi Yokoyama, Mayuka Nakatake, Takeshi Kuwata, Arnaud Couzinet, Ryo Goitsuka, Shuichi Tsutsumi, Hiroyuki Aburatani, Peter J. M. Valk, Ruud Delwel and Takuro Nakamura
JOURNAL OF CLINICAL INVESTIGATION 126 ( 5 ) 1664 - 1678 2016.5( ISSN：0021-9738 )
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Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia. Reviewed
Takashi Yokoyama, Tsutomu Toki, Yoshihiro Aoki, Rika Kanezaki, Myoung-ja Park, Yohei Kanno, Tomoko Takahara, Yukari Yamazaki, Etsuro Ito, Yasuhide Hayashi and Takuro Nakamura
BLOOD 119 ( 11 ) 2608 - 2611 2012.1( ISSN：0006-4971 )
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Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation. Reviewed
Takashi Yokoyama and Takuro Nakamura
CANCER SCIENCE 102 ( 6 ) 1115 - 1122 2011.5( ISSN：1347-9032 )
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Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis. Reviewed
Takashi Yokoyama, Yohei Kanno, Yukari Yamazaki, Tomoko Takahara, Satoshi Miyata and Takuro Nakamura
BLOOD 116 ( 15 ) 2768 - 2775 2010.7( ISSN：0006-4971 )
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DA-Raf1, a competent intrinsic dominant-negative antagonist of Ras-ERK pathway, is required for myogenic differentiation. Reviewed
Takashi Yokoyama, Kazunori Takano, Akira Yoshida, Fumiko Katada, Peng Sun, Tadaomi Takenawa, Toshiwo Andoh and Takeshi Endo
Journal of Cell Biology 177 ( 5 ) 781 - 793 2007.5( ISSN：0021-9525 )
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Sustained activation of M-Ras induced by nerve growth factor is essential for neuronal differentiation of PC12 cells. Reviewed
Peng Sun, Haruko Watanabe, Kazunori Takano, Takashi Yokoyama, Jun-ichi Fujisawa, Takeshi Endo
Genes to cells 2006.9( ISSN：1356-9597 )
Books and Other Publications
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臨床生化学 第7版 Major achievement
宮澤 恵二，根本 清次，横山 隆志，大嶽 茂雄，伊藤 友香，斎藤 正夫（ Role： Joint Work3-1章2〜7節）
2024.1
Presentations
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TRIB1 regulates TGF-β-induced cell motility through degradation of C/EBPα
Takashi Yokoyama, Masao Saito, Keiji Miyazawa
2022.9
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TRIB1 promotes TGF-β-induced cell motility and anchorage-independent growth International conference
Takashi Yokoyama
TGFβ meeting 2022.8
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Identification of the SMAD3 functional domain required to promote antioxidant function and chemoresistance
2022.6
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TGF-β/SMAD3 pathway promotes antioxidant function and chemoresistance Major achievement
2021.5
The total number of announcement other than the above
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2023
Total number of non-preannounced events：3 Number of main presenters：3 Number of presenters other than main person：0
Awards
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優秀演題賞
2021.5 日本がん分子標的治療学会 TGF-β/SMAD3経路は酸化ストレスおよび抗がん剤への耐性を促進する
横山 隆志