University of Yamanashi   Assistant Professor

2016.11

日本学術振興会特別研究員(DC2)

2013.4 - 2015.3

The University of Tokyo

2012.4 - 2016.10

The University of Tokyo

2010.4 - 2012.3

The University of Tokyo

2006.4 - 2010.3

博士（理学） ( 2016.10   東京大学 )

Life Science / Cell biology

TGF-βシグナルによるZEB1の機能活性化機構とその役割の解明

2021.4 - 2023.3

若手研究

がん悪性化促進転写因子ZEB1の機能制御機構に関する研究

2019.4 - 2021.3

若手研究

ウズラの精巣機能制御におけるＡＭＨの役割とその分子機構の解明

2013.4 - 2015.3

特別研究員奨励費 

Smad2Δexon3 and Smad3 have distinct properties in signal transmission leading to TGF-β–induced cell motility Reviewed

Takashi Yokoyama, Takahito Kuga, Yuka Itoh, Shigeo Otake, Chiho Omata, Masao Saitoh, Keiji Miyazawa

JOURNAL OF BIOLOGICAL CHEMISTRY   2023.2

ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus-dependent E-cadherin downregulation Reviewed

Shigeo Otake, Yuka Itoh, Chiho Omata, Masao Saitoh, Keiji Miyazawa

CANCER SCIENCE   2021.1( ISSN：1347-9032 )

成体ウズラの精巣における光周期による性分化関連遺伝子の発現制御とそのAMH情報伝達系への関与

大嶽 茂雄

比較内分泌学   2017( ISSN：1882-6644 )

Expressional changes of AMH signaling system in the quail testis induced by photoperiod. Reviewed

Shigeo Otake and Min Kyun Park

REPRODUCTION   2016.11( ISSN：1470-1626 )

Molecular characterization of two isoforms of ZFAND3 cDNA from the Japanese quail and the leopard gecko, and different expression patterns between testis and ovary. Reviewed

Shigeo Otake, Daisuke Endo, and Min Kyun Park

GENE   2011.11( ISSN：0378-1119 )

TGF-β signaling downregulates CDH1 expression via the ZEB1-dependent chromatin regulation

Shigeo Otake, Masao Saitoh, Keiji Miyazawa

2023.9 

TGF-β downregulates CDH1 expression via the CtBP-independent ZEB1 pathway

Shigeo Otake, Masao Saitoh, Keiji Miyazawa

2022.10 

Novel mechanism of E-cadherin downregulation by ZEB1 and oncogenic Ras

Shigeo Otake

2020.10 

Cooperation of oncogenic K-Ras and PKC signaling downregulates E-cadherin expression by modulating ZEB1 function

Shigeo Otake

2018.9 

病態生理論II

2022Year

生化学実習

2022Year

生化学実習

2021Year

病態生理論II

2021Year

チュートリアル

2019Year

日本癌学会