Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine (Neurophysiology) Assistant Professor
Title
Assistant Professor
Homepage
Murakami Masayoshi
Research History
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University of Yamanashi Graduate Faculty of Interdisciplinary Research Faculty of Medicine Department of Neurophysiology Assistant Professor
2024.4
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Division of Medicine, University of Yamanashi Department of Neurophysiology Project specific assistant professor
2018.7 - 2024.3
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Champalimaud Research postdoctoral fellow
2008.2 - 2018.6
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Cold Spring Harbor Laboratory postdoctoral fellow
2006.1 - 2008.5
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The University of Tokyo Graduate School of Medicine, The University of Tokyo postdoctoral fellow
2005.4 - 2005.12
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Graduate School of Medicine, University of Tokyo Department of Cellular and Molecular Physiology Postdoctoral fellow
2005.4 - 2005.12
Education
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The University of Tokyo Graduate School of Pharmaceutical Sciences
2002.4 - 2005.3
Country： Japan
Course： Doctor course
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The University of Tokyo Graduate School of Pharmaceutical Sciences
2000.4 - 2002.3
Country： Japan
Course： Master course
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The University of Tokyo
1996.4 - 2000.3
Research Areas
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Life Science / Neuroscience-general
Research Interests
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neural circuit
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electrophysiology
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decision-making
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neurophysiology
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systems neuroscience
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motor learning
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Cerebellum
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Electrophysiology
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Motor cortex
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motor learning
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Impulsivity
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Locomotion
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Decision making
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Cerebellum
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prefrontal cortex
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Optogenetics
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Serotonin
Research Projects
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適切な行動選択の神経基盤を「意思決定から行動制御まで」つなげて理解する
Grant number：22K06469 2022.4 - 2025.3
日本学術振興会 基盤研究（C） 基盤研究(C)
村上誠祥
Grant type：Competitive Type of fund：：Science research expense
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Unraveling decision-to-action circuits involved in waiting for delayed rewards
Grant number：19K06882 2019.4 - 2022.3
Japan Society for the Promotion of Science University of Yamanashi Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
Murakami Masayoshi
Authorship：Principal investigator Type of fund：：Science research expense
We aimed at understanding how decision-related activities regulate motor-outputs in decisions regarding whether to keep waiting for delayed rewards or give up waiting.
We first established a behavioral task in which a head-restrained mouse must decide whether to keep waiting for delayed rewards by staying still on a treadmill, or give up waiting by initiating locomotion. Next, we identified a brain region involved in a motor output used in this task, namely, forward locomotion. Optogenetic stimulation of a specific region in the midbrain reliably evoked locomotion, and neural recordings revealed this region contained many locomotion-activated neurons. Finally, we found neurons in several decision-related areas send outputs to this identified locomotor region.
In summary, we identified candidate decision-to-action circuits that involve in decision regarding whether to stay still for delayed rewards or give up waiting by initiating locomotion. -
Neural mechanism of action timing decision based on distribution of reward delays
Grant number：19H05310 2019.4 - 2021.3
Japan Society for the Promotion of Science University of Yamanashi Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area) Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Authorship：Principal investigator Type of fund：：Science research expense
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Multi-scale understanding of prefrontal top-down impulse control
Grant number：19H05208 2019.4 - 2021.3
Japan Society for the Promotion of Science University of Yamanashi Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area) Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Authorship：Principal investigator Type of fund：：Science research expense
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前頭前皮質による衝動性行動のトップダウン制御メカニズムの解明
2019 - 2022
武田科学振興財団 医学系研究助成
村上誠祥
Authorship：Principal investigator Type of fund：：Others
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Neural mechanism of value based decision making of staying or leaving - Deciding when to initiate locomotion to move to the next reward location -
2018.10 - 2021.9
FCT (Portugal) Champalimaud Foundation SR&TD Project Grants
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Prefrontal control of impulsive actions
2009.2 - 2013.1
FCT (Portugal) postdoctoral fellowship
Masayoshi Murakami
Authorship：Principal investigator Grant type：Competitive
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Prefrontal control of impulsive action
2009.1 - 2010.12
Bial foundation Bial Grants for Scientific Research
Masayoshi Murakami, Zachary F. Mainen
Authorship：Principal investigator Grant type：Competitive
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Understanding neural mechanism of withholding impulsive behavior
2007.1 - 2007.12
Uehara Memorial Foundation Research fellowship for Studying Abroad
Masayoshi Murakami
Authorship：Principal investigator Grant type：Competitive
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Neurophysiological study of odor leaning
Grant number：02J08338 2002.4 - 2005.3
Japan Society for the Promotion of Science Research fellowship
Masayoshi Murakami
Authorship：Principal investigator Grant type：Competitive
Papers
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Koji Ikezoe, Naoki Hidaka, Satoshi Manita, Masayoshi Murakami, Shinichiro Tsutsumi, Yoshikazu Isomura, Masanobu Kano, Kazuo Kitamura
Koji Ikezoe, Naoki Hidaka, Satoshi Manita, Masayoshi Murakami, Shinichiro Tsutsumi, Yoshikazu Isomura, Masanobu Kano, Kazuo Kitamura 6 ( 1 ) 2023.9( eISSN：2399-3642 )
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A reservoir of foraging decision variables in the mouse brain Reviewed International coauthorship
Fanny Cazettes, Luca Mazzucato, Masayoshi Murakami, Joao P. Morais, Elisabete Augusto, Alfonso Renart, Zachary F. Mainen
Nature Neuroscience 26 ( 5 ) 840 - 849 2023.4( ISSN：1097-6256 eISSN：1546-1726 )
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Metastable attractors explain the variable timing of stable behavioral action sequences Reviewed
Stefano Recanatesi, Ulises Pereira-Obilinovic, Masayoshi Murakami, Zachary Mainen, Luca Mazzucato
Neuron 110 ( 1 ) 139 - 153 2022.1
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Standardized and reproducible measurement of decision-making in mice Reviewed
The International Brain Laboratory, Valeria Aguillon-Rodriguez, Dora Angelaki, Hannah Bayer, Niccolo Bonacchi, Matteo Carandini, Fanny Cazettes, Gaelle Chapuis, Anne K Churchland, Yang Dan, Eric Dewitt, Mayo Faulkner, Hamish Forrest, Laura Haetzel, Michael Häusser, Sonja B Hofer, Fei Hu, Anup Khanal, Christopher Krasniak, Ines Laranjeira, Zachary F Mainen, Guido Meijer, Nathaniel J Miska, Thomas D Mrsic-Flogel, Masayoshi Murakami, Jean-Paul Noel, Alejandro Pan-Vazquez, Cyrille Rossant, Joshua Sanders, Karolina Socha, Rebecca Terry, Anne E Urai, Hernando Vergara, Miles Wells, Christian J Wilson, Ilana B Witten, Lauren E Wool, Anthony M Zador
eLife 10 ( e63711 ) 2021.5
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More than Just a "Motor": Recent Surprises from the Frontal Cortex. Reviewed
Ebbesen CL, Insanally MN, Kopec CD, Murakami M, Saiki A, Erlich JC.
JOURNAL OF NEUROSCIENCE 38 ( 44 ) 9402 - 9413 2018.10( ISSN：0270-6474 )
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An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals
Kiyohito Iigaya, Madalena S. Fonseca, Masayoshi Murakami, Zachary F. Mainen, Peter Dayan
Nature communications 9 ( 1 ) 277 2018.6
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Distinct Sources of Deterministic and Stochastic Components of Action Timing Decisions in Rodent Frontal Cortex Reviewed Major achievement
Murakami M, Shteingart H, Loewenstein Y, Mainen ZF.
Neuron 94 ( 4 ) 908 - 919 2017.5
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Preparing and selecting actions with neural populations: toward cortical circuit mechanisms Major achievement
Murakami M, Mainen ZF.
CURRENT OPINION IN NEUROBIOLOGY 33 40 - 46 2015.8( ISSN：0959-4388 )
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Activation of Dorsal Raphe Serotonergic Neurons Promotes Waiting but Is Not Reinforcing Major achievement
Fonseca MS, Murakami M, Mainen ZF.
CURRENT BIOLOGY 25 ( 3 ) 306 - 315 2015.2( ISSN：0960-9822 )
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Neural antecedents of self-initiated actions in secondary motor cortex Reviewed Major achievement
Murakami M, Vicente MI, Costa GM, Mainen ZF.
Nature Neuroscience 17 ( 11 ) 1574 - 1582 2014.11
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In vitro odor-aversion conditioning in a terrestrial mollusk Reviewed
Inoue T, Murakami M, Watanabe S, Inokuma Y, Kirino Y.
Journal of Neurophysiology 95 ( 6 ) 3898 - 3903 2006.6
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State-dependent sensory gating in olfactory cortex Reviewed Major achievement
Murakami M, Kashiwadani H, Kirino Y, Mori K.
Neuron 46 ( 2 ) 285 - 296 2005.4
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Odor-evoked responses in the olfactory center neurons in the terrestrial slug. Reviewed
Murakami M, Watanabe S, Inoue T, Kirino Y.
Journal of Neurobiology 58 ( 3 ) 369 - 378 2004.2
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Modulation of oscillatory neural activities by cholinergic activation of interneurons in the olfactory center of a terrestrial slug Reviewed
Watanabe S, Inoue T, Murakami M, Inokuma Y, Kawahara S, Kirino Y.
Brain Research 896 ( 1-2 ) 30 - 35 2001.5
Presentations
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Clustering of climbing fiber inputs conveying lick direction error signals to the cerebellar cortex International conference
Masayoshi Murakami
2025.7
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Clustered error signal inputs to a molecularly defined cerebellar cortical region
Masayoshi Murakami
Biology of Behavior Change The 5th project meeting 2025.6
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Uncovering neural substrates for deciding timing of self-initiated locomotion with large-scale electrophysiological neural recordings International conference Major achievement
Masayoshi Murakami
APPW2025 2025.3
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大脳皮質歩行運動野の発見とその機能の探索
村上 誠祥
第11回遺伝発達行動学セミナー 2024.10
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Neural substrates for deciding timing of self-initiated locomotion International conference Major achievement
Masayoshi Murakami
NEURO2024 2024.7
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Neural substrates for deciding timing of self-initiated locomotion Invited International conference Major achievement
Masayoshi Murakami
The 8th CiNet Conference - Beyond Motor Control: Bridging the gap between action and perception - 2023.3
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Neural substrates for deciding timing of self-initiated locomotion Invited Major achievement
Masayoshi Murakami
2022.3
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Neural substrates of action timing decisions Invited International conference Major achievement
Masayoshi Murakami
Society for Neuroscience, Neueroscience 2018 2018.11
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行動タイミングの決定に関わる前頭皮質の神経活動 Invited Major achievement
村上誠祥
生理研研究会 大脳皮質回路の機能原理を探る 2018.9
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Neural substrates of action timing decisions Invited Major achievement
Masayoshi Murakami
41st Annual Meeting of the Japan Neuroscience Society 2018.7
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Neural substrates of waiting time decisions Invited Major achievement
Masayoshi Murakami
Monash University, Biomedicine Discovery Seminar 2017.11
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Neural substrates of action timing decisions Invited International conference Major achievement
Masayoshi Murakami
Computational and Systems Neuroscience 2017 Workshops “Computations and neural mechanisms underlying decision commitment” 2017.2
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Neural substrates of waiting time decisions Invited Major achievement
Masayoshi Murakami
RIKEN Brain Science Institute Invited seminar 2015.4
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State-dependent sensory gating in olfactory cortex Invited International conference Major achievement
Masayoshi Murakami
CREST-RIKEN Workshop “Real-time computing and Neural Dynamics in the Brain” 2005.3
Teaching Experience (On-campus)
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Neuroscience
2025Year
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Practical training of Physiology
2025Year
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Practical training of Physiology
2024Year
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Neuroscience
2024Year
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Practical training of Physiology
2023Year
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生理学実習
2022Year
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Practical training of Physiology
2021Year Type of subject：Professional education (undergraduate)
Guidance results
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2025
Type：Achievement of student guidance (Undergraduate)
Number of people receiving guidance ：3people
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2024
Type：Achievement of student guidance (Undergraduate)
Number of people receiving guidance ：1people
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2023
Type：Achievement of student guidance (Undergraduate)
Number of people receiving guidance ：1people
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2022
Type：Achievement of student guidance (Undergraduate)
Number of people receiving guidance ：1people
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2021
Type：Achievement of student guidance (Undergraduate) Period：12months
Number of people receiving guidance ：1people
Social Activities
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高校生への公開授業
Role(s)： Organizing member
2025.7
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高校生への公開授業
Role(s)： Organizing member
2024.8
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高校生への公開授業
Role(s)： Advisor
2023.7
Professional Memberships
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日本生理学会
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THE JAPAN NEUROSCIENCE SOCIETY
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The Physiological Society of Japan
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SOCIETY FOR NEUROSCIENCE
Committee Memberships
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日本神経科学学会 プログラム委員
2025.10
Committee type：Society
Media Coverage
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山梨大学ミニ番組「ナシダイブ」～ ライフサイエンスコース編～
UTY・Youtube 2024.10
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山梨日日新聞
訪問！大学ユニーク研究室 2019.8
Academic Activities
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第４８回日本神経科学大会 セッションチェア
Role(s)： Panel moderator, session chair, etc.
日本神経科学学会 2025.7