Updated on 2024/03/26

写真a

 
Kitamura Kazuo
 
Organization
Graduate Faculty of Interdisciplinary Research Faculty of Medicine Basic Science for Clinical Medicine (Neurophysiology) Professor
Title
Professor

Research History

  • University of Yamanashi   Professor

    2014.10

  • The University of Tokyo   Associate Professor

    2010.8 - 2014.9

  • The University of Tokyo   Assistant Professor

    2007.9 - 2010.7

  • Osaka University   Research Associate

    2005.10 - 2007.8

  • 日本学術振興会海外特別研究員   特別研究員

    2003 - 2005

  • ユニバーシティ・カレッジ・ロンドン   ウルフソン生物医学研究所   研究員

    2003 - 2005

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    Country:United Kingdom

    Job classification:Researcher/Postdoc

  • 科学技術振興事業団   一分子過程プロジェクト   研究員   研究員

    1999 - 2003

  • 日本学術振興会特別研究員PD   特別研究員

    1998 - 1999

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Education

  • Osaka University

    - 1998.3

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    Country: Japan

    Course: Doctor later

  • Osaka University

    - 1995.3

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    Country: Japan

    Course: Doctor prophase

  • Osaka University

    - 1993.3

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    Country: Japan

Degree

  • Ph. D. ( 1998.3   Osaka University )

Research Areas

  • Life Science / Basic brain sciences

  • Life Science / Physiology

  • Life Science / Neuroscience-general

Research Interests

  • Neuron, Neocortex, Cerebellum, Motor, Sensation, Electrophysiology, Optical imaging

Subject of research

  • Sensorimotor information processing in the brain and development of advanced optical imaging technique

Papers

  • A multicolor suite for deciphering population coding in calcium and cAMP in vivo. Reviewed

    Yokoyama T, Manita S, Uwamori H, Tajiri M, Imayoshi I, Yagishita S, Murayama M, Kitamura K, Sakamoto M.

    Nature Methods   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41592-024-02222-9

  • Optogenetic stimulation of neurons in the anterior cingulate cortex induces changes in intravesical bladder pressure and the micturition reflex. Reviewed

    Mochizuki T, Manita S, Shimura H, Kira S, Sawada N, Bito H, Sakimura K, Augustine GJ, Mitsui T, Takeda M, Kitamura K.

    Scientific Reports   14   2024.3

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-024-56806-8

  • Dynamic organization of cerebellar climbing fiber response and synchrony in multiple functional components reduces dimensions for reinforcement learning. Reviewed

    Hoang H, Tsutsumi S, Matsuzaki M, Kano M, Kawato M, *Kitamura K, *Toyama K.

    eLife   12   2023.9( ISSN:2050-084X )

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.86340

  • Cerebellar climbing fibers multiplex movement and reward signals during a voluntary movement task in mice Reviewed

    #*Ikezoe K, #Hidaka N, Manita S, Murakami M, Tsutsumi S, Isomura Y, *Kano M, *Kitamura K.

    Communications Biology   6   2023.9

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-023-05309-9

  • In Vivo Wide-Field and Two-Photon Calcium Imaging from a Mouse using a Large Cranial Window. Reviewed

    Manita S, Shigetomi E, Bito H, Koizumi S, Kitamura K

    Jove-Journal of Visualized Experiments   186 ( 186 )   2022.8( ISSN:1940-087X )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Wide-field calcium imaging from the mouse's neocortex allows one to observe cortex-wide neural activity related to various brain functions. On the other hand, two-photon imaging can resolve the activity of local neural circuits at the single-cell level. It is critical to make a large cranial window to perform multiple-scale analysis using both imaging techniques in the same mouse. To achieve this, one must remove a large section of the skull and cover the exposed cortical surface with transparent materials. Previously, glass skulls and polymer-based cranial windows have been developed for this purpose, but these materials are not easily fabricated. The present protocol describes a simple method for making a large cranial window consisting of commercially available polyvinylidene chloride (PVDC) wrapping film, a transparent silicone plug, and a cover glass. For imaging the dorsal surface of an entire hemisphere, the window size was approximately 6 x 3 mm2. Severe brain vibrations were not observed regardless of such a large window. Importantly, the condition of the brain surface did not deteriorate for more than one month. Wide-field imaging of a mouse expressing a genetically-encoded calcium indicator (GECI), GCaMP6f, specifically in astrocytes, revealed synchronized responses in a few millimeters. Two-photon imaging of the same mouse showed prominent calcium responses in individual astrocytes over several seconds. Furthermore, a thin layer of an adeno-associated virus was applied to the PVDC film and successfully expressed GECI in cortical neurons over the cranial window. This technique is reliable and cost-effective for making a large cranial window and facilitates the investigation of the neural and glial dynamics and their interactions during behavior at the macroscopic and microscopic levels.

    DOI: 10.3791/64224

    PubMed

  • A novel device of reaching, grasping, and retrieving task for head-fixed mice. Reviewed

    Manita S, Ikezoe K, Kitamura K

    Frontiers in Neural Circuits   16   2022.5(  eISSN:1662-5110 )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    Reaching, grasping, and retrieving movements are essential to our daily lives and are common in many mammalian species. To understand the mechanism for controlling this movement at the neural circuit level, it is necessary to observe the activity of individual neurons involved in the movement. For stable electrophysiological or optical recordings of neural activity in a behaving animal, head fixation effectively minimizes motion artifacts. Here, we developed a new device that allows mice to perform reaching, grasping, and retrieving movements during head fixation. In this method, agar cubes were presented as target objects in front of water-restricted mice, and the mice were able to reach, grasp, and retrieve them with their forelimb. The agar cubes were supplied by a custom-made automatic dispenser, which uses a microcontroller to control the two motors to push out the agar cubes. This agar presentation system supplied approximately 20 agar cubes in consecutive trials. We confirmed that each agar cube could be presented to the mouse with an average weight of 55 ± 3 mg and positional accuracy of less than 1 mm. Using this system, we showed that head-fixed mice could perform reaching, grasping, and retrieving tasks after 1 week of training. When the agar cube was placed near the mice, they could grasp it with a high success rate without extensive training. On the other hand, when the agar cube was presented far from the mice, the success rate was initially low and increased with subsequent test sessions. Furthermore, we showed that activity in the primary motor cortex is required for reaching movements in this task. Therefore, our system can be used to study neural circuit mechanisms for the control and learning of reaching, grasping, and retrieving movements under head-fixed conditions.

    DOI: 10.3389/fncir.2022.842748

  • Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo. Reviewed

    Sakamoto M, Inoue M, Takeuchi A, Kobari S, Yokoyama T, Horigane S, Takemoto-Kimura S, Abe M, Sakimura K, Kano M, Kitamura K, Fujii H, Bito H.

    Cell Reports Methods   100168 - 100168   2022.2( ISSN:2667-2375 )

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.crmeth.2022.100168

  • A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging. Reviewed

    Rupprecht P, Carta S, Hoffmann A, Echizen M, Blot A, Kwan AC, Dan Y, Hofer SB, Kitamura K, Helmchen F, Friedrich RW.

    NATURE NEUROSCIENCE   24 ( 9 )   1324 - 1337   2021.8( ISSN:1097-6256  eISSN:1546-1726 )

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1038/s41593-021-00895-5

    Other Link: https://www.nature.com/articles/s41593-021-00895-5

  • Improved hyperacuity estimation of spike timing from calcium imaging Reviewed

    Huu Hoang, Masa-Aki Sato, Shigeru Shinomoto, Shinichiro Tsutsumi, Miki Hashizume, Tomoe Ishikawa, Masanobu Kano, Yuji Ikegaya, Kazuo Kitamura, Mitsuo Kawato, Keisuke Toyama

    Scientific Reports   10 ( 1 )   17844 - 17844   2020.10( ISSN:2045-2322  eISSN:2045-2322 )

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    <title>Abstract</title>
    Two-photon imaging is a major recording technique used in neuroscience. However, it suffers from several limitations, including a low sampling rate, the nonlinearity of calcium responses, the slow dynamics of calcium dyes and a low SNR, all of which severely limit the potential of two-photon imaging to elucidate neuronal dynamics with high temporal resolution. We developed a hyperacuity algorithm (HA_time) based on an approach that combines a generative model and machine learning to improve spike detection and the precision of spike time inference. Bayesian inference was performed to estimate the calcium spike model, assuming constant spike shape and size. A support vector machine using this information and a jittering method maximizing the likelihood of estimated spike times enhanced spike time estimation precision approximately fourfold (range, 2–7; mean, 3.5–4.0; 2SEM, 0.1–0.25) compared to the sampling interval. Benchmark scores of HA_time for biological data from three different brain regions were among the best of the benchmark algorithms. Simulation of broader data conditions indicated that our algorithm performed better than others with high firing rate conditions. Furthermore, HA_time exhibited comparable performance for conditions with and without ground truths. Thus HA_time is a useful tool for spike reconstruction from two-photon imaging.

    DOI: 10.1038/s41598-020-74672-y

    PubMed

    Other Link: http://www.nature.com/articles/s41598-020-74672-y

  • Activation of the reward system ameliorates passive cutaneous anaphylactic reaction in mice. Reviewed

    Nakajima S, Manita S, Yu G, Ishimaru K, Kono K, Kitamura K, Nakao A

    ALLERGY   2020.6( ISSN:0105-4538 )

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/all.14442

  • Modular organization of cerebellar climbing fiber inputs during goal-directed behavior. Reviewed

    Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M, Kitamura K.

    eLife   8   e47021   2019.10( ISSN:2050-084X )

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.47021

  • Rational engineering of XCaMPs, a multicolor GECI suite for in vivo imaging of complex brain circuit dynamics. Reviewed

    3. Inoue M, Takeuchi A, Manita S, Horigane S-i, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H.

    CELL   177 ( 5 )   1346 - 1360   2019.5( ISSN:0092-8674 )

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cell.2019.04,007

  • mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory. Reviewed

    2. Nakao H, Kishimoto Y, Hashimoto K, Kitamura K, Yamasaki M, Nakao K, Watanabe M, Kano M, Kirino Y, Aiba A.

    Scientific Reports   9   2019.5( ISSN:2045-2322 )

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-019-43744-z

  • Patchwork-Type Spontaneous Activity in Neonatal Barrel Cortex Layer 4 Transmitted via Thalamocortical Projections Reviewed

    Hidenobu Mizuno, Koji Ikezoe, Shingo Nakazawa, Takuya Sato, Kazuo Kitamura, Takuji Iwasato

    Cell Reports   22   123 - 135   2018.1( ISSN:2211-1247 )

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2017.12.012

  • Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network Reviewed

    Jean-Marc Good, Michael Mahoney, Taisuke Miyazaki, Kenji F Tanaka, Kenji Sakimura, Masahiko Watanabe, Kazuo Kitamura, and Masanobu Kano

    Cell Reports   21 ( 8 )   2066 - 2073   2017.11( ISSN:2211-1247 )

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2017.10.101

  • Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice Reviewed

    Nakai N, Nagano M, Saitow F, Watanabe Y, Kawamura Y, Kawamoto A, Tamada K, Mizuma H, Onoe H, Watanabe Y, Monai H, Hirase H, Nakatani J, Inagaki H, Kawada T, Miyazaki T, Watanabe M, Sato Y, Okabe S, Kitamura K, Kano M, Hashimoto K, Suzuki H, Takumi T

    Science Advances   3 ( 6 )   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciadv.1603001

  • Dendritic Spikes in Sensory Perception Reviewed

    Manita S, Miyakawa H, Kitamura K, Murayama M

    Frontiers in Cellular Neuroscience   11   2017.2( ISSN:1662-5102 )

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fncel.2017.00029

  • Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Reviewed

    NATURE METHODS   12 ( 1 )   64 - 70   2015.1( ISSN:1548-7091 )

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Structure-function relationships between aldolase C/zebrin II expression and complex spike synchrony in the cerebellum. Reviewed

    JOURNAL OF NEUROSCIENCE   35 ( 2 )   843 - 852   2015.1( ISSN:0270-6474 )

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  • Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task. Reviewed

    NATURE NEUROSCIENCE   17 ( 7 )   987 - 994   2014.7( ISSN:1097-6256 )

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  • A highly sensitive fluorescent indicator dye for calcium imaging of neural activity in vitro and in vivo. Reviewed

    EUROPEAN JOURNAL OF NEUROSCIENCE   39 ( 11 )   1720 - 1728   2014.6( ISSN:0953-816X )

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Dendritic calcium signaling in cerebellar Purkinje cell. Reviewed

    Kitamura K.,Kano M.

    NEURAL NETWORKS   47   11 - 17   2013.11( ISSN:0893-6080 )

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Spike timing-dependent selective strengthening of single climbing fibre inputs to Purkinje cells during cerebellar development. Reviewed

    Kawamura Y.,Nakayama H.,Hashimoto K.,Sakimura K., Kitamura K., Kano M.

    Nature Communications   4   2013.11( ISSN:2041-1723 )

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Functional labeling of neuronal ensemble and axonal projections in vivo using a synthetic activity-dependent promoter E-SARE. Reviewed

    NATURE METHODS   10 ( 9 )   889 - 895   2013.9( ISSN:1548-7091 )

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  • Disruption of cerebellar microzonal organization in GluD2 (GluRδ2) knockout mouse. Reviewed

    Hashizume M.,Miyazaki T.,Sakimura K.,Watanabe M., Kitamura K., Kano M.

    Frontiers in Neural Circuits   7   2013.8( ISSN:1662-5110 )

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  • Calcium-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development. Reviewed

    J. Physiol.   591 ( 13 )   3151 - 3158   2013.7

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  • Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Reviewed

    Cell Reports   3 ( 4 )   978 - 987   2013.4

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  • Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement. Reviewed

    J. Neurosci.   33 ( 4 )   1377 - 1390   2013.1

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  • Reinforcing operandum: rapid and reliable learning of skilled forelimb movements by head-fixed rodents. Reviewed

    J. Neurophysiol.   108 ( 6 )   1781 - 1792   2012.9

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  • GABAergic inhibition regulates developmental synapse elimination in the cerebellum. Reviewed

    Neuron   74 ( 2 )   384 - 396   2012.4

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  • Locally synchronized synaptic inputs. Reviewed

    Science   335 ( 6066 )   353 - 356   2012.1

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  • Dendritic calcium signaling triggered by spontaneous and sensory-evoked climbing fiber input to cerebellar Purkinje cells in vivo. Reviewed

    J. Neurosci.   31 ( 30 )   10847 - 10858   2011.7

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  • Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Reviewed

    Proc. Natl. Acad. Sci. USA   108 ( 24 )   9987 - 9992   2011.6

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  • In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice. Reviewed

    J. Physiol.   589 ( 10 )   2447 - 2457   2011.5

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  • Translocation of a ‘‘Winner’’ climbing fiber to the Purkinje cell dendrite and subsequent elimination of ‘‘Losers’’ from the soma in developing cerebellum. Reviewed

    Neuron   63 ( 1 )   106 - 118   2009.7

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  • Spatial pattern coding of sensory information by climbing fiber-evoked calcium signals in networks of neighboring cerebellar Purkinje cells. Reviewed

    J. Neurosci.   29 ( 25 )   8005 - 8015   2009.6

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  • Targeted single-cell electroporation of mammalian neurons in vivo. Reviewed

    Nature Protocols   4 ( 6 )   862 - 869   2009.1

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  • Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo. Reviewed

    Nature Methods   5 ( 1 )   61 - 67   2008.1

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  • Role of multiple bonds between the single cell adhesion molecules, nectin and cadherin, revealed by high sensitive force measurements. Reviewed

    J. Mol. Biol.   367 ( 4 )   996 - 1006   2007.4

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  • The diffusive search mechanisms of processive myosin class-V motor involves directional steps along actin subunits. Reviewed

    Biochem. Biophys. Res. Commun.   354 ( 2 )   379 - 384   2007.3

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  • Bistability of cerebellar Purkinje cells modulated by sensory stimulation. Reviewed

    Nature Neuroscience   8 ( 2 )   202 - 211   2005.2

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  • Mechanism of muscle contraction based on stochastic properties of single actomyosin motors observed in vitro. Reviewed

    BIOPHYSICS   1 ( 1 )   1 - 19   2005.1

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  • Stochastic properties of actomyosin motor. Reviewed

    Biosystems   71 ( 1月2日 )   101 - 110   2003.9

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  • Molecular motors and single-molecule enzymology. Reviewed

    Methods in Enzymology   361   228 - 245   2003.1

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  • Single-motor mechanics and models of the myosin motor. Reviewed

    Phil. Trans. R. Soc. Lond. B   355 ( 1396 )   441 - 447   2000.4

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  • Imaging and nano-manipulation of single actomyosin motors at work. Reviewed

    Clin. Exp. Pharm. Physiol.   27 ( 3 )   229 - 237   2000.3

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  • Single molecule analysis of the actomyosin motor. Reviewed

    Curr. Opin. Cell Biol.   12 ( 1 )   20 - 25   2000.2

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  • A single myosin head moves along an actin filament with regular steps of 5.3 nanometres. Reviewed

    Nature   397 ( 6715 )   129 - 134   1999.1

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  • Non-contact scanning probe microscopy with sub-piconewton force sensitivity. Reviewed

    Ultramicroscopy   70 ( 1月2日 )   45 - 55   1997.12

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  • Single molecule imaging of fluorophores and enzymatic reactions achieved by objective-type total internal reflection fluorescence microscopy. Reviewed

    Biochem. Biophys. Res. Commun.   235 ( 1 )   47 - 53   1997.6

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  • Subpiconewton intermolecular force microscopy. Reviewed

    Biochem. Biophys. Res. Commun.   231 ( 3 )   566 - 569   1997.2

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  • Myosin subfragment-1 is fully equipped with factors essential for motor function. Reviewed

    Biochem. Biophys. Res. Commun.   230 ( 1 )   76 - 80   1997.1

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Presentations

  • Modular Organization of Climbing Fiber Signals During Behavior Invited International conference

    Kazuo Kitamura

    Gorodon Research Conference Cerebellum  2023.8 

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    Event date: 2023.8

    Language:English   Presentation type:Oral presentation(invited, special)  

    Venue:Bates College   Country:United States  

  • Development of cranial windows that allow wide-field and two-photon calcium imaging from the same mouse International conference

    Satoshi Manita, Eiji Shigetomi, Haruhiko Bito, Schuichi Koizumi, Kazuo Kitamura

    The 46th Annual Meeting of Japan Neuroscience Society  2023.8 

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    Event date: 2023.8

    Language:English   Presentation type:Oral presentation(general)  

    Venue:Sendai  

  • Negative reward-prediction errors of climbing fiber inputs for cerebellar reinforcement learning algorithm International conference

    Hoang Thien Huu, Shinichiro Tsutsumi, Masanori Matsuzaki, Masanobu Kano, Keisuke Toyama, Kazuo Kitamura, Mitsuo Kawato

    The 46th Annual Meeting of Japan Neuroscience Society  2023.8 

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    Event date: 2023.8

    Language:English   Presentation type:Poster presentation  

    Venue:Sendai  

  • Deciphering population coding in calcium and cAMP in vivo International conference

    Tatsushi Yokoyama, Satoshi Manita, Hiroyuki Uwamori, Mio Tajiri, Itaru Imayoshi, Sho Yagishita, Masanori Murayama, Kazuo Kitamura, Masayuki Sakamoto

    The 46th Annual Meeting of Japan Neuroscience Society  2023.8 

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    Event date: 2023.8

    Language:English   Presentation type:Oral presentation(general)  

    Venue:Sendai  

  • Spatial organization of climbing fiber inputs conveying different types of error signals to the cerebellar cortex International conference

    Masayoshi Murakami, Tomoki Ishimaru, Keisuke Kameda, Kazuo Kitamura

    The 46th Annual Meeting of Japan Neuroscience Society  2023.8 

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    Event date: 2023.8

    Language:English   Presentation type:Poster presentation  

    Venue:Sendai  

  • Computer simulation of shaping simple spike activity by complex spike data obtained by calcium imaging in cerebellar motor learning International conference

    Tomohiro Mitsuhashi, Koji Ikezoe, Kazuo Kitamura, Tadashi Yamazaki

    The 46th Annual Meeting of Japan Neuroscience Society  2023.8 

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    Event date: 2023.8

    Language:English   Presentation type:Poster presentation  

    Venue:Sendai  

  • Cerebellar Purkinje cells encode behavioral information of multiplex modalities with their complex spikes and form functional modules International conference

    Koji Ikezoe, Naoki Hidaka, Satoshi Manita, Masayoshi Murakami, Shinichiro Tsutsumi, Yoshikazu Isomura, Masanobu Kano, Kazuo Kitamura

    The 100th Anniversary Annual Meeting of The Physiological Society of Japan  2023.3 

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    Event date: 2023.3

    Language:English   Presentation type:Poster presentation  

  • Novel cranial window for in vivo calcium imaging International conference

    Satoshi Manita, Shigetomi Eiji, Haruhiko Bito, Schuichi Koizumi, Kazuo Kitamura

    The 100th Anniversary Annual Meeting of The Physiological Society of Japan  2023.3 

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    Event date: 2023.3

    Language:English   Presentation type:Poster presentation  

  • Establishment of a behavioral task to study neural mechanisms of behavioral adaptations driven by different types of prediction error International conference

    Masayoshi Murakami, Tomoki Ishimaru, Keisuke Kameda, Kazuo Kitamura

    The 100th Anniversary Annual Meeting of The Physiological Society of Japan  2023.3 

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    Event date: 2023.3

    Language:English   Presentation type:Poster presentation  

  • Voltage imaging of simple spikes from Purkinje cells in acute cerebellar slice International conference

    Eikichi Hashida, Satoshi Manita, Kazuo Kitamura

    NEURO2022/ The 45th Annual Meeting of the Japan Neuroscience Society  2022.7 

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    Event date: 2022.7

    Language:English   Presentation type:Poster presentation  

  • A new reaching, grasping, and retrieving task device for mice under head fixation International conference

    Satoshi Manita, Koji Ikezoe, Kazuo Kitamura

    NEURO2022/ The 45th Annual Meeting of the Japan Neuroscience Society  2022.7 

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    Event date: 2022.7

    Language:English   Presentation type:Oral presentation(general)  

  • Establishment of a behavioral task to study neural mechanisms of various types of prediction error driven behavioral adaptations International conference

    Masayoshi Murakami, Tomoki Ishimaru, Kazuo Kitamura

    NEURO2022/ The 45th Annual Meeting of the Japan Neuroscience Society  2022.7 

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    Event date: 2022.7

    Language:English   Presentation type:Poster presentation  

  • Bidirectional associated changes in synchronization and climbing fiber responses of cerebellar Purkinje-cell dependent on compartments along with auditory discrimination go/no-go learning International conference

    Hoang Thien Huu, Shinichiro Tsutsumi, Mitsuo Kawato, Kazuo Kitamura, Keisuke Toyama

    NEURO2022/ The 45th Annual Meeting of the Japan Neuroscience Society  2022.7 

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    Event date: 2022.7

    Language:English   Presentation type:Poster presentation  

  • Neural substrates for deciding timing of self-initiated locomotion

    Masayoshi Murakami, Fanny Cazettes, Zachary F. Mainen, Kazuo Kitamura

    2022.3 

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    Event date: 2022.3

    Language:English   Presentation type:Symposium workshop panel(nominated)  

  • A novel reaching and grasping task for head-fixed mice with an automated agar cube dispenser International conference

    Satoshi Manita, Koji Ikezoe, Kazuo Kitamura

    the 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting  2021.7 

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    Event date: 2021.7

    Language:English   Presentation type:Poster presentation  

  • Synchronicity changes of complex spike activities in cerebellar Purkinje cells during auditory go/no-go task learning studied by hyperacuity two-photon recordings International conference

    Huu Thien Hoang、Shinichiro Tsutsumi、Kazuo Kitamura、Mitsuo Kawato、Keisuke Toyama

    the 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting  2021.7 

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    Event date: 2021.7

    Language:English   Presentation type:Poster presentation  

  • Encoding model analysis of complex spikes of Purkinje cells in mice cerebellum during a voluntary lever-pull task International conference

    Koji Ikezoe, Naoki Hidaka, Satoshi Manita, Masayoshi Murakami, Shinichiro Tsutsumi, Yoshikazu Isomura, Masanobu Kano, Kazuo Kitamura

    the 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting  2021.7 

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    Event date: 2021.7

    Language:English   Presentation type:Poster presentation  

  • Functional organization of cerebellar climbing fiber signals during goal-directed behavior International conference

    Shinichiro Tsutsumi1, Naoki Hidaka1,2, Yoshikazu Isomura3,4, Kazuo Kitamura

    The eighth International Neural Microcircuit Conference  2020.1 

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    Event date: 2020.1

    Language:English   Presentation type:Poster presentation  

  • Functional connectivity between the neocortex and the cerebellum International conference

    Kitamura K

    The 10th IBRO World Congress  2019.9 

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    Event date: 2019.9

    Language:English   Presentation type:Symposium workshop panel(nominated)  

  • Rational enginnering of XCaMPs, a multiclor GECI suite for in vivo imaing of complex brain circuit dynamics. International conference

    Inoue M, Takeuchi A, Manita S, Horigane S, Sakamoto M, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Quirin S, Okamura M, Sakimura K, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H

    Neuro 2019  2019.7 

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    Event date: 2019.7

    Language:English   Presentation type:Oral presentation(general)  

  • Neuronal representation for speed and acceleration of walking in mouse cerebellar cortex. International conference

    Ikezoe K, Kitamura K

    Neuro 2019  2019.7 

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    Event date: 2019.7

    Language:English   Presentation type:Poster presentation  

  • Cerebellar climbing fiber signals represent voluntary forelimb lever-pull trajectories. International conference

    Hidaka N, Ikezoe K, Tsutsumi S, Isomura Y, Kano M, Kitamura K

    Neuro 2019  2019.7 

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    Event date: 2019.7

    Language:English   Presentation type:Oral presentation(general)  

  • Two-photon imaging of population climbing fiber responses in behaving mice International conference

    Kitamura K

    29th Neural Control of Movements Annual Meeting  2019.4 

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    Event date: 2019.4

    Language:English   Presentation type:Symposium workshop panel(nominated)  

  • Neuronal tuning to speed and acceleration of locomotion in mouse cerebellar cortex International conference

    Ikezoe K, Kitamura K

    9th FAOPS Congress  2019.3 

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    Event date: 2019.3

    Language:English   Presentation type:Poster presentation  

  • Neural substrates of action timing decisions International conference

    Murakami M, Cazettes F, Mainen ZF, Kitamura K

    9th FAOPS Congress  2019.3 

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    Event date: 2019.3

    Language:English   Presentation type:Poster presentation  

  • Measurement of multiple cerebellar mossy fiber activities by calcium imaging in mouse International conference

    Manita S, Ikezoe K, Sato M, Ohkura M, Nakai J, Hayashi Y, Kitamura K

    9th FAOPS Congress  2019.3 

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    Event date: 2019.3

    Language:English   Presentation type:Poster presentation  

  • 小脳の運動機能と非運動機能:マウスを用いた研究 Invited

    喜多村和郎

    第9回小脳研究会 学術集会・総会  2019.1 

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    Event date: 2019.1

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

  • Organization of the functional inputs from the sensorimotor cortex to the cerebellum revealed by transcranial optogenetic mapping International conference

    Choo M, Hira R, Matsuzaki M, Ikezoe K, Augustine GJ, Kano M, Kitamura K

    Neuroscience 2018  2018.11 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  • Activity of cerebellar climbing fibers represents forelimb movements during voluntary lever-pull task in mice International conference

    Hidaka N, Tsutsumi S, Ikezoe K, Isomura Y, Kano M, Kitamura K

    Neuroscience 2018  2018.11 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  • Regulation of micturition by the activity of the anterior cingulate cortex in mice International conference

    Mochizuki T, Manita S, Mitsui T, Takeda T, Kitamura K

    Neuroscience 2018  2018.11 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  • Calcium imaging of the cerebellar mossy fiber activities during forelimb movements in mouse International conference

    Manita S, Ikezoe K, Sato M, Ohkura M, Nakai J, Hayashi Y, Kitamura K

    Neuroscience 2018  2018.7 

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    Event date: 2018.7

    Language:English   Presentation type:Poster presentation  

  • Patchwork-type spontaneous activity in neonatal somatosensory cortex transmitted via thalamocortical projections International conference

    Neuroscience 2018  2018.7 

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    Event date: 2018.7

    Language:English   Presentation type:Oral presentation(general)  

  • Control of micturition by manipulation of the activity of the anterior cingulate cortex International conference

    Mochizuki T, Manita S, Shimura H, Imai Y, Ihara T, Kira S, Nakagomi H, Sawada N, Mitsui T, Takeda M, Kitamura K

    Neuroscience 2018  2018.7 

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    Event date: 2018.7

    Language:English   Presentation type:Oral presentation(general)  

  • Two-photon imaging of cerebellar activity during goal-directed behavior International conference

    Kazuo Kitamura

    The first international symposium for fronted brain science: University of Yamanashi  2018.2 

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    Event date: 2018.2

    Language:English   Presentation type:Symposium workshop panel(nominated)  

  • 小脳モジュールの機能解析

    喜多村和郎

    次世代脳冬のシンポジウム2017  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Symposium workshop panel(nominated)  

  • Two-photon imaging of cerebellar activity in vivo Invited International conference

    Kazuo Kitamura

    Two-photon Imaging Course 2017  2017.10 

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    Event date: 2017.10

    Language:English   Presentation type:Public discourse, seminar, tutorial, course, lecture and others  

    Venue:Chongqing, China  

  • マウスを用いた到達運動課題の開発とその性能評価

    真仁田聡、池添貢司、喜多村和郎

    第64回中部日本生理学会  2017.10 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Poster presentation  

  • 随意運動における小脳登上線維シグナルの2光子イメージング解析

    日高直樹、堤新一郎、池添貢司、礒村宜和、狩野方伸、喜多村和郎

    第64回中部日本生理学会  2017.10 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Poster presentation  

  • Maturation of cerebellar climbing fiber and Purkinje cell population activities during postnatal development International conference

    Michael Mahoney, Jean-Marc Good, Taisuke Miyazaki, Kenji F Tanaka, Kenji Sakimura, Masahiko Watanabe, Kazuo Kitamura, Masanobu Kano

    Neuroscience2017  2017.7 

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    Event date: 2017.7

    Language:English   Presentation type:Oral presentation(general)  

  • Two-photon imaging of cerebellar climbing fiber signals during a voluntary movement International conference

    Naoki Hidaka, Shinichiro Tsutsumi, Koji Ikezoe, Yoshikazu Isomura, Masanobu Kano, Kazuo Kitamura

    Neuroscience2017  2017.7 

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    Event date: 2017.7

    Language:English   Presentation type:Poster presentation  

  • Functions of cerebellar modules during goal-directed behavior International conference

    Kazuo Kitamura, Shinichiro Tsutsumi, Naoki Hidaka, Yoshikazu Isomura, Masanori Matsuzaki, Kenji Sakimura, Masanobu Kano

    Neuroscience2017  2017.7 

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    Event date: 2017.7

    Language:English   Presentation type:Oral presentation(general)  

  • Barrel-confined patchwork activity of the somatosensory layer 4 neurons in neonates International conference

    Hidenobu Mizuno, Koji Ikezoe, Takuya Sato, Kazuo Kitamura, Takuji Iwasato 

    Neuroscience2017  2017.7 

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    Event date: 2017.7

    Language:English   Presentation type:Poster presentation  

  • Establishment of a method to observe cerebellar activities during reaching and grasping in mice International conference

    Satoshi Manita, Koji Ikezoe, Taiyo Kawaguchi, Kazuo Kitamura

    Neuroscience2017  2017.7 

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    Event date: 2017.7

    Language:English   Presentation type:Poster presentation  

  • A novel method for assessment of reaching and grasping movements in head-fixed mice.

    Manita S, Ikezoe K, Kitamura K

    2017.3 

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

  • Representation of cerebellar climbing fiber signals during goal-directed behavior and learning. International conference

    Kitamura K

    NIPS International Workshop “Toward elucidation of memory engram”  2016.12 

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    Event date: 2016.12

    Language:English   Presentation type:Oral presentation(invited, special)  

  • Functional differences in climbing fiber inputs to distinct cerebellar stripes during goal-directed behavior. International conference

    Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M, Kitamura K

    Neuroscience 2016  2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

  • 2光子イメージングによる小脳回路研究:発達から運動機能まで

    喜多村和郎

    第63回中部日本生理学会  2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

  • 脳機能の2光子イメージング

    喜多村和郎

    BioOpto Japan 2016  2016.9 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Public discourse, seminar, tutorial, course, lecture and others  

  • Cerebellar lobules receive spatiotemporally specific inputs from the cerebral cortex. International conference

    Choo MJ, Hira R, Matsuzaki M, Kano M, Kitamura K

    第39回日本神経科学大会  2016.7 

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    Event date: 2016.7

    Language:English   Presentation type:Oral presentation(general)  

  • Hyperacuity Bayesian technique to enhance temporal resolution of two-photon recording of complex spikes of cerebellar Purkinje cells. International conference

    Hoang HT, Yamashita O, Tokuda IT, Kitamura K, Sato M, Kawato M, Toyama K

    第39回日本神経科学大会(国際学会)  2016.7 

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    Event date: 2016.7

    Language:English   Presentation type:Oral presentation(general)  

  • Functional organization of cerebellar modules during skilled behavior

    2016.3 

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    Event date: 2016.3

    Language:English   Presentation type:Oral presentation(general)  

  • 2光子イメージングを用いた神経科学研究

    喜多村和郎

    第15回山梨再生・移植研究会  2015.11  山梨再生・移植研究会

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

    Venue:山梨大学  

  • 幸福な研究生活を送るには?

    喜多村和郎

    第3回幸福脳研究会  2015.9 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

    Venue:諏訪湖荘  

  • In vivo 光学イメージングと電気生理学の融合

    喜多村和郎

    第38回日本神経科学大会(教育講演)  2015.7  日本神経科学学会

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

    Venue:神戸国際会議場  

  • 光で探る脳のはたらき~シナプスから回路へ~

    喜多村和郎

    量子エレクトロニクス研究会  2013.12  応用物理学会

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 光で探る脳の活動 ~シナプスからニューロンまで~

    喜多村和郎

    第22回日本バイオイメージング学会学術集会公開講座  2013.9  日本バイオイメージング学会

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

  • 生体内2光子イメージングによる単一ニューロン・単一シナプスの活動計測.

    喜多村和郎

    第2回睡眠研究会  2012.7  睡眠研究会

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 生体内における神経活動の2光子イメージング.

    喜多村和郎

    日本顕微鏡学会第68回学術講演会  2012.6  日本顕微鏡学会

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 大脳皮質における感覚シナプス入力の可視化.

    喜多村和郎

    生理研研究会「シナプス可塑性の動作原理~分子から行動まで~」  2012.6  生理学研究所

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 小脳におけるリズムと同期.

    喜多村和郎

    第12回生理学若手サマースクール  2012.5  生理学若手の会

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    Event date: 2012.5

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

  • Two-photon imaging of neuronal population activities in cerebellar cortex.

    Kazuo Kitamura

    第34回日本分子生物学会年会  2011.12  日本分子生物学会

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    Event date: 2011.12

    Language:English   Presentation type:Oral presentation(general)  

  • 発達期小脳における神経回路形成のin vivo解析.

    河村吉信,中山寿子,喜多村和郎,狩野方伸

    生理学研究所研究会「大脳皮質局所回路の機能原理」  2011.12  生理学研究所

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    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 樹状突起活動のin vivoイメージングと光操作.

    喜多村和郎

    第2回光操作研究会  2011.12  光操作研究会

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    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation(general)  

  • Heterogeneous organization of sensory synaptic inputs in the mouse barrel cortex.

    Kazuo Kitamura

    生理研国際研究集会「Cutting edge in synapse research」  2011.11  生理学研究所

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    Event date: 2011.11

    Language:English   Presentation type:Oral presentation(invited, special)  

  • Two-photon imaging of Purkinje cell dendritic activity in vivo.

    Kazuo Kitamura

    8th IBRO World Congress of Neuroscience  2011.7  IBRO

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    Event date: 2011.7

    Language:English   Presentation type:Oral presentation(general)  

  • Simultaneous two-photon calcium imaging and patch-clamp recordings in vivo.

    Kazuo Kitamura,Michael Hausser,Masanobu Kano

    Jacques Monod Conference “Imaging brain circuits in health and disease”  2010.7  CNRS

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    Event date: 2010.7

    Language:English   Presentation type:Oral presentation(general)  

  • 生体内における神経活動の2光子イメージング.

    喜多村和郎

    第5回日本分子イメージング学会総会・学術集会  2010.5  日本分子イメージング学会

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    Event date: 2010.5

    Language:Japanese   Presentation type:Oral presentation(invited, special)  

  • 小脳シナプス回路のin vivo解析.

    喜多村和郎

    第115回日本解剖学会総会・全国学術集会  2010.3  日本解剖学会

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    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 覚醒個体脳におけるホールセル記録と2光子イメージング.

    喜多村和郎

    第47回日本生物物理学会年会  2009.11  日本生物物理学会

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    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 覚醒マウスにおける小脳プルキンエ細胞のホールセル記録.

    喜多村和郎

    第32回日本神経科学大会  2009.9  日本神経科学学会

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 動物個体脳における神経活動の多光子励起顕微鏡による観察.

    喜多村和郎

    光・量子デバイス研究会  2009.2  電気学会

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    Event date: 2009.2

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 小脳皮質における登上線維微小帯域のin vivo2光子イメージングによる解析.

    喜多村和郎,橋爪幹,狩野方伸

    生理学研究所研究会「細胞機能を制御するシグナリング機構の普遍性と特異性」  2008.10  生理学研究所

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    Event date: 2008.10

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 2光子イメージングを用いた個体脳単一ニューロンからの選択的記録法とその可能性.

    喜多村和郎

    第31回日本神経科学大会  2008.7  日本神経科学学会

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    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation(general)  

  • Targeted whole-cell recordings from unlabeled neurons in vivo.

    Kazuo Kitamura

    NIPS-JST国際研究集会「神経科学における非線形イメージングと蛍光バイオセンサーの最前線」  2008.4  生理学研究所

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    Event date: 2008.4

    Language:English   Presentation type:Oral presentation(invited, special)  

  • 単一ニューロンにおけるシナプス統合のin vivoパッチクランプと2光子イメージングによる解析.

    喜多村和郎

    「統合脳」ワークショップ「樹状突起・スパイン」  2007.8  統合脳

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    Event date: 2007.8

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 新しいin vivo可視化パッチクランプ法の開発とその応用.

    喜多村和郎

    第84回日本生理学会大会  2007.3  日本生理学会

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    Event date: 2007.3

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 生体内における神経活動の 2 光子励起イメージング.

    喜多村和郎

    生理学研究所研究会「シナプス可塑性の分子的基盤」  2006.6  生理学研究所

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    Event date: 2006.6

    Language:Japanese   Presentation type:Oral presentation(general)  

  • 分子機械のゆらぎと機能.

    喜多村和郎

    第41回日本生物物理学会年会  2003.9  日本生物物理学会

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    Event date: 2003.9

    Language:Japanese   Presentation type:Oral presentation(general)  

  • アクトミオシンモーターの1分子運動解析.

    喜多村和郎,田中裕人

    第37回日本生物物理学会年会  1999.10  日本生物物理学会

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    Event date: 1999.10

    Language:Japanese   Presentation type:Oral presentation(general)  

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Awards

  • 平成22年度科学技術分野の文部科学大臣表彰 若手科学者賞

    2010.4   文部科学省  

    喜多村和郎

  • 井上研究奨励賞

    2001.3   (財)井上科学振興財団  

    喜多村 和郎

Teaching Experience (On-campus)

  • Neuroscience

    2023Year

  • Advanced lecture on Neuroscien ce

    2023Year

  • Concepts of Integrated Applied Life Science

    2023Year

  • Life Science I (Basic Medical Sciences: Physiological Regulation & Function)

    2023Year

  • Physiology

    2023Year

  • 生理学

    2017Year  Type of subject:Common education (undergraduate)

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Social Activities

  • 脳の不思議な世界 -世界脳週間2- 

    Role(s): Lecturer

    2023.7

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    Audience: High school students

    Type:Other

  • SSH高大連携講座

    Role(s): Lecturer

    甲陵高校  2023.7

  • サイエンスフォーラム for 高校生 in 山梨大学医学部 「脳のはたらきを観る」

    Role(s): Lecturer

    2022.8

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    Audience: High school students

    Type:Lecture

  • 脳の不思議な世界 -世界脳週間2- 

    Role(s): Lecturer

    2022.7

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    Audience: High school students

  • 山梨大学Future Seed

    Role(s): Appearance

    エフエム富士  GOOD DAY  2020.2 - 2020.3

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    Audience: General

    Type:TV or radio program

  • 脳の話

    Role(s): Lecturer

    山梨大学附属中学校  2019.10

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    Audience: Junior students

  • 脳の話

    Role(s): Lecturer

    山梨大学アドミッションセンター  第3回YAMANASHI-WAY2018  2018.11

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Professional Memberships

  • 日本小脳学会

  • 日本生理学会

  • 日本神経科学学会

  • Society for Neuroscience